Abstract

The present disclosure relates to compounds of Formula I and II and pharmaceutically acceptable salts thereof: The present disclosure relates to compounds of Formula I and II and pharmaceutically acceptable salts thereof: The present disclosure relates to compounds of Formula I and II and pharmaceutically acceptable salts thereof: and a pharmaceutical composition including a compound of formula I or II and a pharmaceutically acceptable excipient. Also provided is a method of administering a compound of formula I or II or a physiological salt thereof, or said pharmaceutical composition to a subject, wherein the subject suffers from kidney disease or is at risk of kidney disease.

IPC Classes  ?

• C07D 235/18 - BenzimidazolesHydrogenated benzimidazoles with aryl radicals directly attached in position 2
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• C07D 471/04 - Ortho-condensed systems

Abstract

The present disclosure is concerned with borylated amidoximes useful in the synthesis of biologically relevant drug-like molecules, including functionalized oxadizole and quinazolinone derivatives. Also disclosed are methods of making borylated amidoximes, methods of making functionalized oxadiazole and quinazolinone compounds using the amidoximes, and functionalized oxadiazole and quinazolinone compounds prepared from borylated amidoximes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• C07F 5/04 - Esters of boric acids
• C07C 259/12 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
• C07C 259/16 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxyamidine groups bound to carbon atoms of rings other than six-membered aromatic rings
• C07C 259/18 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxyamidine groups bound to carbon atoms of six-membered aromatic rings
• C07C 257/10 - Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
• C07C 257/16 - Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of rings other than six-membered aromatic rings
• C07C 257/18 - Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings

Abstract

The present disclosure relates to compounds of Formula I and II and pharmaceutically acceptable salts thereof: and a pharmaceutical composition including a compound of formula I or II and a pharmaceutically acceptable excipient. Also provided is a method of administering a compound of formula I or II or a physiological salt thereof, or said pharmaceutical composition to a subject, wherein the subject suffers from kidney disease or is at risk of kidney disease.

IPC Classes  ?

• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• C07D 235/04 - BenzimidazolesHydrogenated benzimidazoles
• C07D 235/18 - BenzimidazolesHydrogenated benzimidazoles with aryl radicals directly attached in position 2
• C07D 471/04 - Ortho-condensed systems

Goods & Services

Headwear; Wristbands as clothing; Clothing, namely, t-shirts, shirts, sweatshirts, polo shirts, pants, hoodies, shorts, sweatpants; Face masks being headwear; Jerseys being clothing; Caps being clothing; Visors being headwear Retail store services featuring books, clothing, t-shirts, shirts, sweatshirts, polo shirts, pants, hoodies, shorts, sweatpants, jerseys being clothing, headwear, visors being headwear, caps being clothing, wristbands as clothing, face masks, backpacks, tote bags, cinch sacs being all-purpose carrying bags, glassware, mugs, stuffed toy animals, bottled water, water bottles, sold empty, flags, lap blankets, cloth banners, keychains, hand sanitizer preparations, lanyard for holding ID cards, lanyards for holding eyeglasses, sunglasses, pouches made of foam specifically adapted for phones, pencils, pens, folders for paper, paper notebooks, printed daily planners, decals, stickers Education services, namely, providing sports training in the fields of college baseball, basketball, softball, cross country, golf, track, wrestling, hockey, lacrosse, soccer, rowing, swimming, wrestling, bowling, equestrian, fencing, gymnastics, rugby, and volleyball; Entertainment in the nature of competitions in the field of collegiate athletics, sports events; Providing entertainment news and information specifically in the field of sports via a website; Arranging and conducting of sports events; Entertainment services in the nature of college athletes competing in baseball, basketball, softball, cross country, golf, track, wrestling, hockey, lacrosse, soccer, rowing, swimming, wrestling, bowling, equestrian, fencing, gymnastics, rugby, and volleyball events

Goods & Services

Promoting live entertainment events for others; business and event management of live entertainment events; operation and management of live entertainment venues; promoting ticket sales for live entertainment events for others Entertainment Services, namely, the production and presentation of Theatrical and Musical Shows and Performances; providing facilities for live entertainment events

Abstract

The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.

IPC Classes  ?

• A61K 31/785 - Polymers containing nitrogen
• A61P 31/12 - Antivirals
• A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• C08F 8/32 - Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
• C08H 8/00 - Macromolecular compounds derived from lignocellulosic materials
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C08B 15/06 - Derivatives containing elements other than carbon, hydrogen, oxygen, halogen, or sulfur containing nitrogen
• C08B 31/00 - Preparation of chemical derivatives of starch
• A01N 25/10 - Macromolecular compounds
• D06M 13/477 - Compounds containing quaternary nitrogen atoms derived from heterocyclic compounds having six-membered heterocyclic rings
• D06M 16/00 - Biochemical treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, e.g. enzymatic
• D06M 101/32 - Polyesters
• D06M 101/06 - Vegetal fibres cellulosic
• D06M 101/12 - Keratin fibres or silk

Abstract

The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.

IPC Classes  ?

• C08B 37/16 - CyclodextrinDerivatives thereof

Abstract

The present invention is directed to providing antimicrobial compositions consisting of a polymeric material and, embedded therein, an antimicrobial compound. The antimicrobial compound contains at least one quaternary ammonium group, at least one hydrocarbon chain comprising a minimum of 10 carbon atoms and a maximum of 24 carbon atoms, and one or more anions to balance the charge of the quaternary ammonium groups. The invention is also directed to a method of making antimicrobial compositions containing an antimicrobial compound embedded in a polymeric material.

IPC Classes  ?

• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests

Abstract

The present invention is directed to providing antimicrobial compositions consisting of a polymeric material and, embedded therein, an antimicrobial compound. The antimicrobial compound contains at least one quaternary ammonium group, at least one hydrocarbon chain comprising a minimum of 10 carbon atoms and a maximum of 24 carbon atoms, and one or more anions to balance the charge of the quaternary ammonium groups. The invention is also directed to a method of making antimicrobial compositions containing an antimicrobial compound embedded in a polymeric material.

IPC Classes  ?

• A01N 25/34 - Shaped forms, e.g. sheets, not provided for in any other group of this main group

Abstract

The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.

IPC Classes  ?

• A61K 31/785 - Polymers containing nitrogen
• A61P 31/12 - Antivirals
• A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• D06M 13/477 - Compounds containing quaternary nitrogen atoms derived from heterocyclic compounds having six-membered heterocyclic rings
• D06M 16/00 - Biochemical treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, e.g. enzymatic

Abstract

The present invention is directed to providing antimicrobial surfaces containing l,4-diazoniabicyclo[2.2.2]octane and hydrocarbon groups and/or chains. More specifically, the present invention is directed to antimicrobial compositions wherein the hydroxyl groups on polyols are replaced by 1,4- diazoniabicyclo[2.2.2]octane. The invention is also directed to methods of making antimicrobial compositions containing polyols.

IPC Classes  ?

• A61K 31/00 - Medicinal preparations containing organic active ingredients