Abstract

The invention relates to chemistry of organic substances, pharmacology and medicine, and concerns treating diseases associated and with aberrant activity of cells of the immune system, more particularly for treating lung, respiratory tract and abdominal diseases, radiation sickness and pain syndrome, and also other diseases by using compounds of formula (A) The invention relates to chemistry of organic substances, pharmacology and medicine, and concerns treating diseases associated and with aberrant activity of cells of the immune system, more particularly for treating lung, respiratory tract and abdominal diseases, radiation sickness and pain syndrome, and also other diseases by using compounds of formula (A) The invention relates to chemistry of organic substances, pharmacology and medicine, and concerns treating diseases associated and with aberrant activity of cells of the immune system, more particularly for treating lung, respiratory tract and abdominal diseases, radiation sickness and pain syndrome, and also other diseases by using compounds of formula (A) wherein The invention relates to chemistry of organic substances, pharmacology and medicine, and concerns treating diseases associated and with aberrant activity of cells of the immune system, more particularly for treating lung, respiratory tract and abdominal diseases, radiation sickness and pain syndrome, and also other diseases by using compounds of formula (A) wherein R1 is —C(O)—R2—C(O)— or —R2—C(O)n— group, where R2 is —(CH2)n— group optionally substituted with one or two C1-C6 alkyls, or phenyl, The invention relates to chemistry of organic substances, pharmacology and medicine, and concerns treating diseases associated and with aberrant activity of cells of the immune system, more particularly for treating lung, respiratory tract and abdominal diseases, radiation sickness and pain syndrome, and also other diseases by using compounds of formula (A) wherein R1 is —C(O)—R2—C(O)— or —R2—C(O)n— group, where R2 is —(CH2)n— group optionally substituted with one or two C1-C6 alkyls, or phenyl, n is an integer from 0 to 4; The invention relates to chemistry of organic substances, pharmacology and medicine, and concerns treating diseases associated and with aberrant activity of cells of the immune system, more particularly for treating lung, respiratory tract and abdominal diseases, radiation sickness and pain syndrome, and also other diseases by using compounds of formula (A) wherein R1 is —C(O)—R2—C(O)— or —R2—C(O)n— group, where R2 is —(CH2)n— group optionally substituted with one or two C1-C6 alkyls, or phenyl, n is an integer from 0 to 4; wherein compounds are selected from the group consisting of the group of compounds as set out in the description. These compounds, as well as pharmaceutically acceptable salts thereof, are highly effective in inhibiting glutaminyl cyclase, which is involved, in particular, in processes of post-translational modification of chemokines and chemotaxis of monocytes, macrophages and other cells of the immune system. This invention also relates to pharmaceutical compositions comprising a therapeutically effective amount of the compounds of formula (A) as defined above.

IPC Classes  ?

• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
• A61P 37/00 - Drugs for immunological or allergic disorders
• C12N 9/10 - Transferases (2.)

Goods & Services

Antibiotics; germicides; dietary supplements, including used for the prevention and treatment of throat diseases; biocides, used in compositions intended for the treatment of sore throats; lotions-sprays for pharmaceutical purposes; medicinal oils in spray form; drugs for medical purposes; medicines for human purposes; medicinal drinks; medicinal infusions; pharmaceutical preparations; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations.

Goods & Services

Dietary supplements; mineral food supplements; drugs for medical purposes; medicines for human purposes; pharmaceutical preparations; preparations for medical purposes; chemico-pharmaceutical preparations.

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; oxygen cylinders, filled, for medical purposes; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; massage gels for medical purposes; sexual stimulant gels; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; contraceptive sponges; gamboge for medical purposes; gurjun balsam for medical purposes; deodorizers for litter trays; deodorants for clothing and textiles; air deodorizing preparations; deodorants, other than for human beings or for animals; diastase for medical purposes; digitalin; vitamin supplement patches; mineral dietary supplements; nutritional supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; brewer's yeast dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; whey protein dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; cannabidiol for medical use; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; haemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine for medical purposes; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; cannabis for medical purposes; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; cultures of microorganisms for medical or veterinary use; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines with neuroprotective properties; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; bone void fillers comprised of living tissues; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; aromatic deodorizers for toilets; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton swabs for medical purposes; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated toothpaste; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; swim diapers, reusable, for babies; swim diapers, disposable, for babies; diapers for incontinence; disposable absorbent pads for lining pet crates; diaper changing mats, disposable, for babies; disposable house training pads for pets; bunion pads; breast-nursing pads; diagnostic strips for testing breast milk for medical purposes; pomades for medical purposes; powder of cantharides; pyrethrum powder; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; acne treatment preparations; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; bronchodilating preparations; preparations for reducing sexual activity; sterilizing preparations; soil-sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying vermin; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; styptic preparations; medicated eye-washes; medicinal hair growth preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; sulfonamides [medicines]; pharmaceutical preparations; pharmaceutical preparations for the treatment of neurodegenerative diseases; pharmaceutical preparations for the treatment of acute ischemic stroke; pharmaceutical preparations for the treatment of amyotrophic lateral sclerosis; pharmaceutical preparations for treating sunburn; pharmaceutical preparations for slowing the progression of functional disorders in patients with amyotrophic lateral sclerosis; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; chilblain preparations; mothproofing preparations; collyrium; lead water; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellents; insect repellent incense; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; crystallized rock sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; parasiticides; mouthwashes for medical purposes; medicated dentifrices; febrifuges; depuratives; medicines for use in therapy for recovery after a stroke; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; purgatives; remedies for perspiration; remedies for foot perspiration; anti-inflammatories; chemical contraceptives; antiparasitic preparations; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; digestives for pharmaceutical purposes; nervines; bouillons for bacteriological cultures; steroids; headache relief sticks; strychnine; suppositories; serums for medical purposes; tanning pills; appetite suppressant pills; slimming pills; antioxidant pills; sanitary tampons; vulnerary sponges; tetrahydrocannabidinol [THC] for medical use; thymol for pharmaceutical purposes; smoking herbs for medical purposes; medicinal herbs; transplants [living tissues]; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; bath tea for therapeutic purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; jujube, medicated; rat poison; poisons; bacterial poisons; jalap.

Abstract

The invention relates to the fields of medicine, pharmacology and the chemical and pharmaceutical industry, and more particularly to a novel crystalline form of 1-[2-(1-methylimidazole-4-yl)-ethyl]perhydroazine-2,6-dione and to a pharmaceutical composition and a drug containing same, which can be used for the treatment and/or prophylaxis of viral respiratory diseases.

IPC Classes  ?

• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61P 31/12 - Antivirals
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses

Goods & Services

Cough treatment medicines.

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; antibiotics; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; balms for medical purposes; bandages for dressings; biocides; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; aseptic cotton; antiseptic cotton; absorbent cotton; wadding for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; gamboge for medical purposes; gurjun balsam for medical purposes; deodorants, other than for human beings or for animals; diastase for medical purposes; digitalin; feed additives for medical purposes; mineral food supplements; nutritional supplements for medical purposes; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; candies for medical purposes; haemostatic pencils; wart pencils; caustic pencils; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; adhesive tapes for medical purposes; cocaine for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; adhesive plasters; medicines for alleviating constipation; lecithin for medical purposes; lotions for veterinary purposes; dog lotions for veterinary purposes; lotions for pharmaceutical purposes; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; anti-horsefly oils; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; royal jelly for medical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for babies; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; decoctions for pharmaceutical purposes; antiparasitic collars for animals; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pants, absorbent, for incontinence; pectin for pharmaceutical purposes; sanitary wraps for incontinence; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pills for pharmaceutical purposes; leeches for medical purposes; blood plasma; adhesive patches for medical purposes; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; bunion pads; breast-nursing pads; pomades for medical purposes; powder of cantharides; pyrethrum powder; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air deodorizing preparations; air purifying preparations; bronchodilating preparations; sterilizing preparations; soil-sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying noxious animals; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; vermin destroying preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; lime-based preparations for pharmaceutical purposes; medicated bath preparations; medicinal hair growth preparations; opiates; anticryptogamic preparations; preparations of trace elements for human and animal use; sulfonamides [medicines]; pharmaceutical preparations; pharmaceutical preparations for treating sunburn; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; chilblain preparations; mothproofing preparations; collyrium; lead water; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; food for babies; dietetic foods adapted for medical purposes; by-products of the processing of cereals for medical purposes; sanitary towels; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; insect repellent incense; insect repellents; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; asthmatic tea; fumigating sticks; candles for medical purposes; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; soporifics; bicarbonate of soda for pharmaceutical purposes; salts for mineral water baths; bath salts for medical purposes; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; anaesthetics; antiseptics; analgesics; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; medical preparations for slimming purposes; parasiticides; mouthwashes for medical purposes; febrifuges; depuratives; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; vesicants; headache treatment preparations; remedies for perspiration; remedies for foot perspiration; chemical contraceptives; antiparasitic preparations; laxatives; tonics [medicines]; nervines; digestives for pharmaceutical purposes; bouillons for bacteriological cultures; steroids; strychnine; serums for medical purposes; sanitary tampons; vulnerary sponges; thymol for pharmaceutical purposes; surgical tissues for medical purposes; smoking herbs for medical purposes; medicinal herbs; sedatives; surgical implants comprised of living tissues; sanitary panties; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; herbal teas for medicinal purposes; slimming tea for medical purpose; eucalyptus for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; jujube, medicated; rat poison; poisons; bacterial poisons; jalap.

Abstract

N,N'N,N'-bis-[2-(1Н-imidazol-4-yl)ethyl]propanediamide and to a pharmaceutical composition and a dosage form containing same, which can be used for the treatment and/or prophylaxis of mucosal inflammation of the upper respiratory tract.

IPC Classes  ?

• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61K 31/4172 - Imidazole-alkanecarboxylic acids, e.g. histidine
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• A61P 37/08 - Antiallergic agents
• A61P 11/02 - Nasal agents, e.g. decongestants

Abstract

The invention relates to pharmacology, medicine and the chemical and pharmaceutical industry, and more particularly to a novel liquid dosage form and a pharmaceutical composition for the treatment and/or prophylaxis of rhinitis, containing N,N'-bis-[2-(1Н-imidazol-4-yl)ethyl]malonamide. The present invention makes it possible to produce N,N'-bis-[2-(1Н-imidazol-4-yl)ethyl]malonamide-containing dosage forms with improved properties for the treatment and/or prophylaxis of rhinitis, including allergic rhinitis.

IPC Classes  ?

• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61K 47/10 - Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• A61K 47/12 - Carboxylic acids; Salts or anhydrides thereof
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 37/00 - Drugs for immunological or allergic disorders

Goods & Services

Abrasives; amber [perfume]; descaling preparations for household purposes; antiperspirants [toiletries]; antistatic preparations for household purposes; aromatics [essential oils]; air fragrancing preparations; cake flavourings [essential oils]; flavourings for beverages [essential oils]; food flavourings [essential oils]; canned pressurized air for cleaning and dusting purposes; balms, other than for medical purposes; basma [cosmetic dye]; lip glosses; nail glitter; body glitter; polishing stones; abrasive paper; emery paper; polishing paper; petroleum jelly for cosmetic purposes; cobblers' wax; cotton wool for cosmetic purposes; cotton wool impregnated with make-up removing preparations; drying agents for dishwashing machines; adhesives for cosmetic purposes; scented water; Javelle water; lavender water; micellar water; toilet water; wax for parquet floors; floor wax; non-slipping wax for floors; depilatory wax; moustache wax; shoe wax; tailors' wax; creams for leather; polish for furniture and flooring; shoemakers' wax; polishing wax; massage gels, other than for medical purposes; heliotropine; dental bleaching gels; geraniol; starch glaze for laundry purposes; make-up; deodorants for pets; deodorants for human beings or for animals; depilatory preparations; air fragrance reed diffusers; scented wood; perfumes; non-slipping liquids for floors; windscreen cleaning liquids; greases for cosmetic purposes; volcanic ash for cleaning; perfumery; decorative transfers for cosmetic purposes; ionone [perfumery]; shaving stones [astringents]; alum stones [astringents]; smoothing stones; eyebrow pencils; teeth whitening pens; cosmetic pencils; silicon carbide [abrasive]; carbides of metal [abrasives]; adhesives for affixing false eyelashes; adhesives for affixing false hair; hair conditioners; quillaia bark for washing; corundum [abrasive]; beard dyes; colorants for toilet purposes; cosmetic dyes; body paint for cosmetic purposes; starch for laundry purposes; shoe cream; skin whitening creams; polishing creams; cosmetic creams; essential oil-based creams for aromatherapy use; polishing rouge; incense; hair spray; nail varnish; liquid latex body paint for cosmetic purposes; hair lotions; lotions for cosmetic purposes; after-shave lotions; beauty masks; sheet masks for cosmetic purposes; disposable steam-heated masks, not for medical purposes; oils for perfumes and scents; oils for cosmetic purposes; oils for toilet purposes; essential oils; essential oils for aromatherapy use; essential oils of cedarwood; essential oils of lemon; essential oils of citron; oils for cleaning purposes; bergamot oil; gaultheria oil; jasmine oil; lavender oil; almond oil; rose oil; oil of turpentine for degreasing; whiting; cleaning chalk; almond milk for cosmetic purposes; cleansing milk for toilet purposes; musk [perfumery]; deodorant soap; shaving soap; soap for brightening textile; cakes of toilet soap; antiperspirant soap; soap for foot perspiration; soap; almond soap; mint for perfumery; emery; gel eye patches for cosmetic purposes; nail art stickers; double eyelid tapes; false nails; eau de Cologne; make-up palettes containing cosmetics; joss sticks; pastes for razor strops; toothpaste; pumice stone; lipstick cases; hydrogen peroxide for cosmetic purposes; dressings for nail reconstruction; polishes for shining shoes; breath freshening strips; teeth whitening strips; sandcloth; glass cloth [abrasive cloth]; lipsticks; pomades for cosmetic purposes; shaving preparations; cosmetic preparations for baths; bath preparations, not for medical purposes; hair straightening preparations; hair waving preparations; laundry soaking preparations; grinding preparations; smoothing preparations [starching]; colour-removing preparations; leather bleaching preparations; polishing preparations; denture polishes; mouthwashes, not for medical purposes; cosmetic preparations for slimming purposes; preparations to make the leaves of plants shiny; eye-washes, not for medical purposes; fabric softeners for laundry use; douching preparations for personal sanitary or deodorant purposes [toiletries]; dry-cleaning preparations; paint stripping preparations; lacquer-removing preparations; make-up removing preparations; floor wax removers [scouring preparations]; varnish-removing preparations; rust removing preparations; nail care preparations; cleaning preparations; preparations for cleaning dentures; wallpaper cleaning preparations; preparations for unblocking drain pipes; chemical cleaning preparations for household purposes; collagen preparations for cosmetic purposes; bleaching preparations [decolorants] for household purposes; aloe vera preparations for cosmetic purposes; sunscreen preparations; colour-brightening chemicals for household purposes [laundry]; breath freshening preparations for personal hygiene; shining preparations [polish]; make-up powder; diamantine [abrasive]; stain removers; wax melts [fragrancing preparations]; nail varnish removers; vaginal washes for personal sanitary or deodorant purposes; scouring solutions; false eyelashes; antistatic dryer sheets; baby wipes impregnated with cleaning preparations; colour run prevention laundry sheets; tissues impregnated with cosmetic lotions; tissues impregnated with make-up removing preparations; safrol; sachets for perfuming linen; massage candles for cosmetic purposes; laundry blueing; turpentine for degreasing; potpourris [fragrances]; bleaching soda; washing soda, for cleaning; bath salts, not for medical purposes; bleaching salts; fumigation preparations [perfumes]; leather preservatives [polishes]; ammonia [volatile alkali] [detergent]; breath freshening sprays; cooling sprays for cosmetic purposes; astringents for cosmetic purposes; eyebrow cosmetics; make-up preparations; sun-tanning preparations [cosmetics]; hair dyes; neutralizers for permanent waving; laundry glaze; cosmetic preparations for eyelashes; laundry preparations; cosmetic preparations for skin care; dentifrices; cosmetics; cosmetics for children; cosmetics for animals; cleansers for intimate personal hygiene purposes, non medicated; detergents, other than for use in manufacturing operations and for medical purposes; degreasers, other than for use in manufacturing processes; bleaching preparations [decolorants] for cosmetic purposes; laundry bleach; toiletry preparations; skin hydrators for cosmetic purposes; phytocosmetic preparations; serums for cosmetic purposes; detergent tablets for coffee machines; talcum powder, for toilet use; cotton swabs for cosmetic purposes; terpenes [essential oils]; emery cloth; toners for cosmetic purposes; tripoli stone for polishing; cloths impregnated with a detergent for cleaning; mascara; henna [cosmetic dye]; bath tea for cosmetic purposes; shampoos for animals [non-medicated grooming preparations]; shampoos for pets [non-medicated grooming preparations]; dry shampoos; shampoos; laundry balls filled with laundry detergents; sandpaper; cosmetic stamps, filled; soda lye; herbal extracts for cosmetic purposes; extracts of flowers [perfumes]; ethereal essences; badian essence; mint essence [essential oil]. Aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antidepressants; antioxidant pills for use as food supplements; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; bromine for pharmaceutical purposes; paper for mustard plasters; reagent paper for veterinary purposes; reagent paper for medical purposes; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fiber including for treating constipation; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; sexual stimulant gels; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; contraceptive sponges; vulnerary sponges; gamboge for medical purposes; gurjun balsam for medical purposes; disinfectants for sanitary purposes; disinfectants; air deodorizing preparations; deodorants, other than for human beings or for animals; deodorants for clothing and textiles; diastase for medical purposes; digitalin; vitamin supplement patches; mineral food supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; haemostatic pencils; wart pencils; caustic pencils; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine for medical purposes; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; cannabis for medical purposes; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; candy for medical purposes; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; bone void fillers comprised of living tissues; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; nootropics; opium; opodeldoc; aromatic deodorizers for toilets; decoctions for pharmaceutical purposes; cotton swabs for medical purposes; stick liquorice for pharmaceutical purposes; moxa rolls for moxibustion; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated toothpaste; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; diapers for incontinence; bunion pads; breast-nursing pads; pomades for medical purposes; powder of cantharides; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; veterinary preparations for treatment of intestinal bacteria; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; pharmaceutical preparations for memory consolidation; haemorrhoid preparations; preparations for callouses; cardiovascular treatment preparations; acne treatment preparations; preparations for chronic alcohol addiction; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; preparations for improving physical and mental performance, stress tolerance; preparations for hypoxia prophylaxis; bronchodilating preparations; preparations for reducing sexual activity; sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; styptic preparations; medicated eye-washes; medicinal hair growth preparations; fonturacetam-based preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; preparations for obesity; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; purgative preparations; sulfonamides [medicines]; pharmaceutical preparations for the treatment of central nervous system [CNS] diseases; pharmaceutical preparations for treating cardiovascular diseases; pharmaceutical preparations for treating sunburn; pharmaceutical preparations for the central nervous system; pharmaceutical preparations including for the treatment of digestive diseases; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for pharmaceutical purposes; chilblain preparations; central nervous system stimulants; collyrium; lead water; probiotic preparations for medical purposes to help maintain a natural balance of flora in the digestive system; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; anti-seizure medications; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; suppositories; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; medical preparations for slimming purposes; mouthwashes for medical purposes; febrifuges; depuratives; detergents for medical purposes; vesicants; purgatives; remedies for perspiration; remedies for foot perspiration; chemical contraceptives; psychotropic drugs for medical purposes; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; digestives for pharmaceutical purposes; nervines; bouillons for bacteriological cultures; steroids; serums for medical purposes; tanning pills; appetite suppressant pills; slimming pills; jujube, medicated; antioxidant pills; sanitary tampons; thymol for pharmaceutical purposes; smoking herbs for medical purposes; medicinal herbs; transplants [living tissues]; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; medicated shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; jalap. Demonstration of goods; opinion polling; market studies; business investigations; business research; marketing research; layout services for advertising purposes; marketing; marketing in the framework of software publishing; targeted marketing; development of advertising concepts; business appraisals; providing business information; providing commercial information and advice for consumers in the choice of products and services; presentation of goods on communication media, for retail purposes; sales promotion for others; promotion of goods and services through sponsorship of sports events; production of teleshopping programmes; production of advertising films; office machines and equipment rental; rental of advertising time on communication media; publicity material rental; rental of billboards [advertising boards]; rental of vending machines; rental of sales stands; radio advertising; bill-posting; distribution of samples; dissemination of advertising matter; direct mail advertising; advertising; online advertising on a computer network; outdoor advertising; advertising by mail order; television advertising; procurement services for others [purchasing goods and services for other businesses]; retail services for pharmaceutical, veterinary and sanitary preparations and medical supplies; wholesale services for pharmaceutical, veterinary and sanitary preparations and medical supplies. Medical advice for individuals with disabilities; pharmacy advice; aromatherapy services; medical examination for quarantine clearance purposes; palliative care; medical assistance; preparation of prescriptions by pharmacists; rehabilitation for substance abuse patients; health care; health counselling; medical clinic services; medical analysis services for diagnostic and treatment purposes provided by medical laboratories; hospital services; nursing home services; therapy services; nursing, medical; health centre services; hospice services; health center services.

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; oxygen cylinders, filled, for medical purposes; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; massage gels for medical purposes; sexual stimulant gels; haematogen; haemoglobin; herbicides; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; contraceptive sponges; vulnerary sponges; gamboge for medical purposes; gurjun balsam for medical purposes; deodorizers for litter trays; deodorants for clothing and textiles; air deodorizing preparations; deodorants, other than for human beings or for animals; aromatic deodorizers for toilets; diastase for medical purposes; digitalin; dietary supplements for human beings; mineral dietary supplements; nutritional supplements; nutritional supplements using for replenishment of vitamins В deficiency; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; brewer's yeast dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; whey protein dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; gum for medical purposes; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; cannabidiol for medical use; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; haemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine for medical purposes; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; cannabis for medical purposes; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; bone void fillers comprised of living tissues; narcotics; medicinal infusions; tincture of iodine; tinctures for medical purposes; opium; opodeldoc; mouthwashes for medical purposes; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton swabs for medical purposes; stick liquorice for pharmaceutical purposes; moxa rolls for moxibustion; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated toothpaste; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; vitamin supplement patches; nicotine patches for use as aids to stop smoking; jujube, medicated; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; swim diapers, reusable, for babies; swim diapers, disposable, for babies; diapers for incontinence; disposable absorbent pads for lining pet crates; diaper changing mats, disposable, for babies; disposable house training pads for pets; bunion pads; breast-nursing pads; diagnostic strips for testing breast milk for medical purposes; pomades for medical purposes; powder of cantharides; pyrethrum powder; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; acne treatment preparations; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; medical preparations for slimming purposes; bronchodilating preparations; preparations for reducing sexual activity; douching preparations for medical purposes; sterilizing preparations; soil-sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying vermin; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; styptic preparations; medicated eye-washes; medicinal hair growth preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; sulfonamides [medicines]; pharmaceutical preparations for the prevention and treatment of neurological diseases; pharmaceutical preparations for the prevention and treatment of neuritis; pharmaceutical preparations for the treatment of central and peripheral nervous system; pharmaceutical preparations for the prevention and treatment of diseases caused by a lack of vitamins B; pharmaceutical preparations for treating sunburn; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; chilblain preparations; mothproofing preparations; collyrium; lead water; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellents; insect repellent incense; repellents for dogs; wipes impregnated with disinfectants for hygiene purposes; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; crystallized rock sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; disinfectants; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; parasiticides; medicated dentifrices; febrifuges; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; weedkillers; purgatives; remedies for perspiration; remedies for foot perspiration; anti-inflammatories; chemical contraceptives; antiparasitic preparations; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; skin hydrators being injectable dermal fillers; digestives for pharmaceutical purposes; nervines; bouillons for bacteriological cultures; steroids; headache relief sticks; strychnine; bismuth subnitrate for pharmaceutical purposes; suppositories; serums for medical purposes; tanning pills; appetite suppressant pills; slimming pills; antioxidant pills; sanitary tampons; tetrahydrocannabidinol [THC] for medical use; thymol for pharmaceutical purposes; depuratives; smoking herbs for medical purposes; medicinal herbs; transplants [living tissues]; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; fennel for medical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; bath tea for therapeutic purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; eucalyptol for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; rat poison; poisons; bacterial poisons; jalap.

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; oxygen cylinders, filled, for medical purposes; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; massage gels for medical purposes; sexual stimulant gels; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; contraceptive sponges; gamboge for medical purposes; gurjun balsam for medical purposes; deodorizers for litter trays; air deodorizing preparations; deodorants, other than for human beings or for animals; deodorants for clothing and textiles; diastase for medical purposes; digitalin; vitamin supplement patches; mineral food supplements; nutritional supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; haemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine for medical purposes; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; cannabis for medical purposes; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for the treatment of infectious and inflammatory diseases of nasal cavity, throat, paranasal sinuses; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; bone void fillers comprised of living tissues; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton swabs for medical purposes; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated toothpaste; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; swim diapers, reusable, for babies; swim diapers, disposable, for babies; diapers for incontinence; diaper changing mats, disposable, for babies; bunion pads; breast-nursing pads; pomades for medical purposes; powder of cantharides; pyrethrum powder; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; acne treatment preparations; topical otolaryngologic medicines; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; bronchodilating preparations; preparations for reducing sexual activity; sterilizing preparations; soil-sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying vermin; preparations for destroying noxious animals; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; styptic preparations; medicated eye-washes; medicinal hair growth preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; sulfonamides [medicines]; pharmaceutical preparations; pharmaceutical preparations for treating sunburn; pharmaceutical preparations for the treatment of acute and chronic rhinopharyngitis; pharmaceutical preparations for the treatment of acute and chronic rhinitis; pharmaceutical preparations for the treatment of sinusitis; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; chilblain preparations; mothproofing preparations; collyrium; lead water; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellents; insect repellent incense; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; crystallized rock sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; medicated nasal spray preparations; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants; disinfectants for hygiene purposes; appetite suppressants for medical purposes; medical preparations for slimming purposes; parasiticides; mouthwashes for medical purposes; medicated dentifrices; febrifuges; depuratives; medications for treatment and prevention of otolaryngologic diseases; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; purgatives; remedies for perspiration; remedies for foot perspiration; chemical contraceptives; antiparasitic preparations; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; digestives for pharmaceutical purposes; nervines; bouillons for bacteriological cultures; steroids; headache relief sticks; strychnine; suppositories; serums for medical purposes; tanning pills; appetite suppressant pills; slimming pills; jujube, medicated; antioxidant pills; sanitary tampons; vulnerary sponges; thymol for pharmaceutical purposes; smoking herbs for medical purposes; medicinal herbs; transplants [living tissues]; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; rat poison; poisons; bacterial poisons; jalap.

Abstract

The invention relates to the field of medicine, pharmacology and the chemical and pharmaceutical industry, and more particularly to a novel crystalline form of 1-(2-(1H-imidazole-4-yl)-ethyl)piperidine-2,6-dione and to a pharmaceutical composition and a drug containing same, which can be used for the treatment and/or prophylaxis of cough.

IPC Classes  ?

• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61P 11/14 - Antitussive agents

Abstract

The invention relates to the field of pharmaceutics and medicine and concerns the use of 1-(2-(1H-imidazole-4-yl)-ethyl)piperidine-2,6-dione or its pharmaceutically acceptable salt, as well as pharmaceutical compositions containing same, for the treatment and/or prophylaxis of cough caused by viral infections.

IPC Classes  ?

• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61P 11/14 - Antitussive agents

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre, including dietary fiber for treating constipation; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; sexual stimulant gels; topical gels for medical and therapeutic purposes; anti-inflammatory gels; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; gamboge for medical purposes; gurjun balsam for medical purposes; disinfectants; deodorants, other than for human beings or for animals; air deodorizing preparations; deodorants for clothing and textiles; diastase for medical purposes; digitalin; vitamin supplement patches; mineral food supplements; dietary and nutritional supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; haemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine for medical purposes; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; medicated candies; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; frostbite salve for pharmaceutical purposes; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton swabs for medical purposes; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated toothpaste; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; diapers for incontinence; breast-nursing pads; bunion pads; pomades for medical purposes; powder of cantharides; pyrethrum powder; chilblain preparations; mothproofing preparations; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; veterinary preparations for treatment of intestinal bacteria; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; acne treatment preparations; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; bronchodilating preparations; preparations for reducing sexual activity; sterilizing preparations; soil-sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying noxious animals; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; preparations for destroying parasites; pharmaceutical preparations for skin care; contact lens cleaning preparations; lime-based pharmaceutical preparations; preparations of microorganisms for medical or veterinary use; styptic preparations; medicated eye-washes; medicinal hair growth preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; antivirals; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; bowel evacuant preparations; sulfonamides [medicines]; pharmaceutical preparations for the treatment of digestive diseases; pharmaceutical preparations for treating sunburn; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; collyrium; lead water; probiotic preparations for medical purposes to help maintain a natural balance of flora in the digestive system; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; solvents for removing adhesive plasters; nasal rinses; hydrated chloral for pharmaceutical purposes; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellents; insect repellent incense; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; suppositories; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; mineral water salts; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; antibacterial sprays; medicinal sprays; medicated nasal spray preparations; decongestant nasal sprays; nasal sprays for medical purposes; cooling sprays for medical purposes; anti-inflammatory sprays; herbal sprays for medical purposes; digestives for pharmaceutical purposes; nervines; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; medical preparations for slimming purposes; parasiticides; mouthwashes for medical purposes; febrifuges; depuratives; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; purgatives; chemical contraceptives; antiparasitic preparations; remedies for perspiration; remedies for foot perspiration; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; bouillons for bacteriological cultures; steroids; strychnine; serums; antioxidant pills; tanning pills; appetite suppressant pills; slimming pills; jujube, medicated; sanitary tampons; vulnerary sponges; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; smoking herbs for medical purposes; medicinal herbs; transplants [living tissues]; surgical implants comprised of living tissues; babies' diaper-pants; pants, absorbent, for incontinence; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; rat poison; poisons; bacterial poisons; jalap.

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; oxygen cylinders, filled, for medical purposes; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; massage gels for medical purposes; sexual stimulant gels; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; contraceptive sponges; gamboge for medical purposes; gurjun balsam for medical purposes; deodorizers for litter trays; air deodorizing preparations; deodorants, other than for human beings or for animals; deodorants for clothing and textiles; diastase for medical purposes; digitalin; vitamin supplement patches; mineral food supplements; nutritional supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; haemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine for medical purposes; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; cannabis for medical purposes; medicated sweets; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; cannabis for medical purposes; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; bone void fillers comprised of living tissues; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton swabs for medical purposes; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated toothpaste; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; swim diapers, reusable, for babies; swim diapers, disposable, for babies; diapers for incontinence; diaper changing mats, disposable, for babies; bunion pads; breast-nursing pads; pomades for medical purposes; powder of cantharides; pyrethrum powder; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; acne treatment preparations; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; bronchodilating preparations; preparations for reducing sexual activity; sterilizing preparations; soil-sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying vermin; preparations for destroying noxious animals; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; styptic preparations; medicated eye-washes; medicinal hair growth preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; sulfonamides [medicines]; pharmaceutical preparations; pharmaceutical preparations for treating sunburn; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; chilblain preparations; mothproofing preparations; collyrium; lead water; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellents; insect repellent incense; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; crystallized rock sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; medical preparations for slimming purposes; parasiticides; mouthwashes for medical purposes; medicated dentifrices; febrifuges; depuratives; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; purgatives; remedies for perspiration; remedies for foot perspiration; chemical contraceptives; antiparasitic preparations; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; digestives for pharmaceutical purposes; nervines; bouillons for bacteriological cultures; steroids; headache relief sticks; strychnine; suppositories; serums; tanning pills; appetite suppressant pills; slimming pills; jujube, medicated; antioxidant pills; cotton wool swabs for medical purposes; sanitary tampons; vulnerary sponges; thymol for pharmaceutical purposes; smoking herbs for medical purposes; medicinal herbs; sedatives; transplants [living tissues]; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; injectable dermal fillers; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; rat poison; poisons; bacterial poisons; jalap; antidepressants; psychoactive substances with anxiolytic effect; preparations for the treatment of nervous system disorders; pharmaceutical preparations including for the treatment of anxiety disorders and anxiety; pharmaceutical preparations for the treatment of vegetative-vascular dystonia; pharmaceutical preparations for use as adjunctive therapy in alcohol withdrawal; pharmaceutical preparations using for the treatment of panic attacks and depression; non-benzodiazepines chemico-pharmaceutical preparations; anxiolytics.

Goods & Services

Vitamin preparations; mineral food supplements; nutritional supplements for medical purposes; drugs for medical purposes; medicines for human purposes; dietetic beverages adapted for medical purposes; medicinal infusions; tinctures for medical purposes; pharmaceutical preparations; chemico-pharmaceutical preparations; chemical preparations for pharmaceutical purposes; pharmaceutical preparations for the treatment of multiple sclerosis; pharmaceutical preparations for the treatment and reduce symptoms of Attention Deficit Hyperactivity Disorder; pharmaceutical drugs; sedatives; medicated lozenges; pharmaceutical preparations and substances for the treatment of neurodegenerative diseases and disorders, including Alzheimer's disease, Parkinson's disease, age-related memory loss and other types of dementia; enzymes for medical purposes; ferments for pharmaceutical purposes.

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antidepressants; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; oxygen cylinders, filled, for medical purposes; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; massage gels for medical purposes; sexual stimulant gels; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; contraceptive sponges; gamboge for medical purposes; gurjun balsam for medical purposes; deodorizers for litter trays; air deodorizing preparations; deodorants, other than for human beings or for animals; deodorants for clothing and textiles; diastase for medical purposes; digitalin; vitamin supplement patches; mineral food supplements; nutritional supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; capsules with medicines; haemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine for medical purposes; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; cannabis for medical purposes; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; centrally acting muscle relaxants; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; bone void fillers comprised of living tissues; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton swabs for medical purposes; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated toothpaste; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; swim diapers, reusable, for babies; swim diapers, disposable, for babies; diapers for incontinence; diaper changing mats, disposable, for babies; bunion pads; breast-nursing pads; pomades for medical purposes; powder of cantharides; pyrethrum powder; antihistamines; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; preparations for treating of pain syndrome; haemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; acne treatment preparations; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; bronchodilating preparations; preparations for reducing sexual activity; sterilizing preparations; soil-sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying vermin; preparations for destroying noxious animals; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; styptic preparations; medicated eye-washes; medicinal hair growth preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; sulfonamides [medicines]; preparations, stimulating the central nervous system; preparations for the treatment of depressive disorders; preparations for increasing resistance to stress; pharmaceutical preparations for the treatment of central nervous system [CNS] diseases; pharmaceutical preparations for treating muscle spasms; pharmaceutical preparations for muscle tone reduction; pharmaceutical preparations; pharmaceutical preparations in the form of tablets; pharmaceutical preparations, namely muscle relaxants; pharmaceutical preparations for treating spastic state of skeletal muscle caused by neurological diseases; pharmaceutical preparations for nervous system reinforcement; pharmaceutical preparations for treating sunburn; enzyme preparations for veterinary purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; chilblain preparations; collyrium; lead water; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellent incense; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; crystallized rock sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; medical preparations for slimming purposes; parasiticides; mouthwashes for medical purposes; medicated dentifrices; febrifuges; depuratives; medicines; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; purgatives; remedies for perspiration; remedies for foot perspiration; chemical contraceptives; antiparasitic preparations; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; digestives for pharmaceutical purposes; nervines; hypnotic sedatives; bouillons for bacteriological cultures; steroids; headache relief sticks; strychnine; suppositories; serums; tanning pills; appetite suppressant pills; slimming pills; jujube, medicated; antioxidant pills; sanitary tampons; vulnerary sponges; thymol for pharmaceutical purposes; smoking herbs for medical purposes; medicinal herbs; transplants [living tissues]; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; rat poison; poisons; bacterial poisons; jalap.

Abstract

The present invention relates to novel biologically active compounds, in particular dicarboxylic acid bisamide derivatives of general formula I: The present invention relates to novel biologically active compounds, in particular dicarboxylic acid bisamide derivatives of general formula I: The present invention relates to novel biologically active compounds, in particular dicarboxylic acid bisamide derivatives of general formula I: or pharmaceutically acceptable salts thereof, which are able to form complexes with or chelate metal ions. The invention also relates to the use of said compounds as an agent for the prevention and/or treatment of cardiovascular, viral, cancer, neurodegenerative and inflammatory diseases, diabetes, age-related diseases, diseases caused by microbial toxins, alcoholism and alcoholic cirrhosis, anaemia, porphyria cutanea tarda, and transition metal salt poisoning. The present invention also relates to novel methods for preparing dicarboxylic acid bisamide derivatives of general formula I.

IPC Classes  ?

• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 233/64 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
• C07D 235/14 - Radicals substituted by nitrogen atoms
• C07D 277/64 - Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
• C07D 277/28 - Radicals substituted by nitrogen atoms
• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; oxygen cylinders, filled, for medical purposes; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; massage gels for medical purposes; sexual stimulant gels; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; contraceptive sponges; gamboge for medical purposes; gurjun balsam for medical purposes; diastase for medical purposes; digitalin; vitamin supplement patches; mineral food supplements; nutritional supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; acai powder dietary supplements; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; haemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine for medical purposes; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; cannabis for medical purposes; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; bone void fillers comprised of living tissues; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton swabs for medical purposes; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated toothpaste; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; swim diapers, reusable, for babies; swim diapers, disposable, for babies; diapers for incontinence; diaper changing mats, disposable, for babies; bunion pads; breast-nursing pads; pomades for medical purposes; powder of cantharides; pyrethrum powder; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; acne treatment preparations; preparation for the prevention and treatment of symptoms of toxicosis; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; bronchodilating preparations; preparations for reducing sexual activity; sterilizing preparations; soil-sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying vermin; preparations for destroying noxious animals; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; styptic preparations; medicated eye-washes; nutraceutical preparations for therapeutic or medical purposes; opiates; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; sulfonamides [medicines]; pharmaceutical preparations; pharmaceutical preparations for treating sunburn; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; chilblain preparations; mothproofing preparations; collyrium; lead water; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellents; insect repellent incense; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; crystallized rock sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; medical preparations for slimming purposes; parasiticides; mouthwashes for medical purposes; medicated dentifrices; febrifuges; depuratives; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; purgatives; chemical contraceptives; antiparasitic preparations; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; digestives for pharmaceutical purposes; remedies for nausea and vomiting; nervines; bouillons for bacteriological cultures; steroids; headache relief sticks; strychnine; suppositories; serums; tanning pills; appetite suppressant pills; slimming pills; jujube, medicated; antioxidant pills; sanitary tampons; vulnerary sponges; thymol for pharmaceutical purposes; smoking herbs for medical purposes; medicinal herbs; transplants [living tissues]; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; rat poison; poisons; bacterial poisons; jalap.

Abstract

The invention relates to the field of pharmaceuticals and medicine and concerns the use of 1-[2-(1-methylimidazole-4-yl)-ethyl]perhydroazine-2,6-dione or its pharmaceutically acceptable salts for the treatment and/or prophylaxis of COVID-19 and its symptoms.

IPC Classes  ?

• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

The invention relates to pharmacology, medicine and the chemical and pharmaceutical industry, and more particularly to a pharmaceutical composition containing 1-[2-(1-methylimidazole-4-yl)-ethyl]perhydroazine-2,6-dione or its pharmaceutically acceptable salts, and auxiliary substances, said composition having a residual water content of not more than 0.1-10 wt% of its total weight, for the treatment and/or prophylaxis of upper respiratory tract diseases.

IPC Classes  ?

• A61K 31/45 - Non-condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 47/02 - Inorganic compounds
• A61K 47/12 - Carboxylic acids; Salts or anhydrides thereof
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/28 - Dragees; Coated pills or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 31/12 - Antivirals

Abstract

The invention relates to a group of compounds which can be used as hepatoprotective agents. The invention further relates to a pharmaceutical composition which exhibits hepatoprotective activity and contains an effective amount of a compound from said group and at least one pharmaceutically acceptable excipient.

IPC Classes  ?

• C07D 339/04 - Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 241/12 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 471/04 - Ortho-condensed systems
• C07C 229/36 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
• C07C 321/06 - Thiols having mercapto groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
• C07C 229/08 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
• C07C 323/60 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
• C07C 229/24 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
• C07C 33/24 - Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part polycyclic without condensed ring systems
• C07F 9/22 - Amides of acids of phosphorus
• C07F 9/38 - Phosphonic acids (R—P(:O)(OH)2); Thiophosphonic acids
• C07F 9/6574 - Esters of oxyacids of phosphorus
• A61K 31/385 - Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
• A61K 31/195 - Carboxylic acids, e.g. valproic acid having an amino group
• A61K 31/216 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
• A61K 31/065 - Diphenyl-substituted acyclic alcohols
• A61K 31/4965 - Non-condensed pyrazines
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
• A61K 31/664 - Amides of phosphorus acids
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The invention relates to the field of organic chemistry and pharmacy and provides a novel compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2H-chromen-2-on-7-yl sulphate, a method for treating and preventing functional gastrointestinal disorders, which comprises administering an effective amount of compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxy benzoate 4-methyl-2H-chromen-2-on-7-yl sulphate to a patient in need thereof, a pharmaceutical composition based on compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2H-chromen-2-on-7-yl sulphate, a drug comprising compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2H-chromen-2-on-7-yl sulphate, and a finished dosage form comprising compound [L-(dimethylamino)-2-phenybutyl ]-3,4,5 -trimethoxybenzoate 4-methyl-2H-chromen-2-on-7-yl sulphate. The invention further relates to the use of compound [2-(dimethylamino) phenylbutyl]-3,4,5-trimethoxy benzoate 4-methyl-2H-chromen-2-on-7-yl sulphate for treating and preventing functional gastrointestinal disorders.

IPC Classes  ?

• C07D 311/16 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
• C07C 219/14 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system

Abstract

The invention relates to the field of medicine and the chemical and pharmaceutical industry, and more particularly to improved Gramicidin S-containing substances comprising specific amounts of novel cyclic decapeptides from the Gramicidin S family, as well as to pharmaceutical compositions containing same for treating inflammatory infectious diseases.

IPC Classes  ?

• C07K 7/66 - Gramicidins S, C; Tyrocidins A, B, C; Related peptides
• A61K 38/12 - Cyclic peptides
• A61P 31/04 - Antibacterial agents

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; oxygen cylinders, filled, for medical purposes; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; massage gels for medical purposes; sexual stimulant gels; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; contraceptive sponges; gamboge for medical purposes; gurjun balsam for medical purposes; deodorizers for litter trays; air deodorizing preparations; deodorants, other than for human beings or for animals; deodorants for clothing and textiles; diastase for medical purposes; digitalin; vitamin supplement patches; mineral food supplements; nutritional supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; haemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine for medical purposes; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; cannabis for medical purposes; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; medicinal oils; camphor oil for medical purposes; mustard oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; bone void fillers comprised of living tissues; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton swabs for medical purposes; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated toothpaste; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; swim diapers, reusable, for babies; swim diapers, disposable, for babies; diapers for incontinence; diaper changing mats, disposable, for babies; bunion pads; breast-nursing pads; pomades for medical purposes; powder of cantharides; pyrethrum powder; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; acne treatment preparations; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; bronchodilating preparations; preparations for reducing sexual activity; sterilizing preparations; soil-sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying vermin; preparations for destroying noxious animals; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; styptic preparations; medicated eye-washes; medicinal hair growth preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; sulfonamides [medicines]; pharmaceutical preparations; pharmaceuticals for the treatment of cough, pharyngitis, laryngitis and tracheitis; pharmaceutical preparations for the treatment and prevention of viral diseases; pharmaceutical preparations for the prevention and treatment of colds, including pharmaceutical preparations for the prevention and treatment of colds in the form of suspensions; pharmaceuticals for the treatment of eosinophilic diseases and diseases of the upper respiratory conditions; antivirals in the form of tablets, capsules, suspensions and drops; pharmaceutical antitussive-cold preparations; pharmaceutical preparations for treating sunburn; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; chilblain preparations; mothproofing preparations; collyrium; lead water; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellents; insect repellent incense; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; crystallized rock sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; medical preparations for slimming purposes; parasiticides; mouthwashes for medical purposes; medicated dentifrices; febrifuges; depuratives; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; purgatives; remedies for perspiration; remedies for foot perspiration; chemical contraceptives; antiparasitic preparations; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; digestives for pharmaceutical purposes; nervines; bouillons for bacteriological cultures; steroids; headache relief sticks; strychnine; suppositories; serums for medical purposes; tanning pills; appetite suppressant pills; slimming pills; jujube, medicated; antioxidant pills; sanitary tampons; vulnerary sponges; thymol for pharmaceutical purposes; smoking herbs for medical purposes; medicinal herbs; transplants [living tissues]; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; rat poison; poisons; bacterial poisons; jalap.

Abstract

The invention relates to the field of pharmacology, and more particularly to compounds with lysosomotropic activity. Proposed is the use of known chemical compounds as agents with lysosomotropic and antiviral activity. The present invention further relates to pharmaceutical compositions and medicaments containing said compounds with lysosomotropic activity. The property of selective accumulation in lysosomes, discovered for said compounds, lends them potential as antiviral agents for the treatment and/or prophylaxis of viral infections, including viral respiratory infections such as influenza, which act on the pH-dependent stages taking place in intracellular structures (the lysosomal apparatus, the endoplasmic reticulum and the Golgi apparatus) during the life cycle of viruses spread by the airborne or fecal-oral route.

IPC Classes  ?

• A61K 31/4523 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/4245 - Oxadiazoles
• A61K 31/4425 - Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/473 - Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
• A61K 31/4745 - Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/136 - Amines, e.g. amantadine having aromatic rings, e.g. methadone having the amino group directly attached to the aromatic ring, e.g. benzeneamine
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 31/12 - Antivirals
• A61P 31/14 - Antivirals for RNA viruses
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

The invention relates to the field of organic chemistry and pharmaceutics and concerns novel compounds suitable for the treatment or prophylaxis of functional disorders of the biliary tract.

IPC Classes  ?

• C07C 69/90 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl and carboxyl groups
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 31/24 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
• A61P 1/06 - Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
• A61P 1/14 - Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Abstract

The proposed invention relates to the use of 2-(imidazol-4-yl)-ethanamide 1,5-pentanedioic acid or a pharmaceutically acceptable salt thereof to treat COVID-19 and its symptoms.

IPC Classes  ?

• A61K 31/417 - Imidazole-alkylamines, e.g. histamine, phentolamine
• A61P 31/14 - Antivirals for RNA viruses

Goods & Services

Pharmaceuticals for the treatment of cough, pharyngitis, laryngitis and tracheitis; pharmaceutical preparations for the treatment and prevention of viral diseases; pharmaceutical preparations for the treatment and prevention of colds, including preparations in the form of suspensions; pharmaceuticals for the treatment of eosinophilic diseases and diseases of the upper respiratory tract; antivirals in the form of tablets, capsules, suspensions and drops; pharmaceuticals against runny nose and cough, using for acute viral infections of the upper respiratory tract.

Goods & Services

Abrasives; amber [perfume]; descaling preparations for household purposes; antistatic preparations for household purposes; aromatics [essential oils]; air fragrancing preparations; cake flavourings [essential oils]; flavourings for beverages [essential oils]; food flavourings [essential oils]; breath freshening sprays; canned pressurized air for cleaning and dusting purposes; balms, other than for medical purposes; basma [cosmetic dye]; lip glosses; nail glitter; polishing stones; abrasive paper; emery paper; polishing paper; petroleum jelly for cosmetic purposes; shoe polish; cobblers' wax; cotton wool for cosmetic purposes; sachets for perfuming linen; drying agents for dishwashing machines; adhesives for cosmetic purposes; scented water; Javelle water; lavender water; toilet water; wax for parquet floors; floor wax; non-slipping wax for floors; depilatory wax; moustache wax; tailors' wax; creams for leather; polish for furniture and flooring; shoemakers' wax; polishing wax; massage gels, other than for medical purposes; heliotropine; dental bleaching gels; geraniol; make-up; deodorants for pets; deodorants for human beings or for animals; depilatory preparations; air fragrance reed diffusers; scented wood; perfumes; non-slipping liquids for floors; windscreen cleaning liquids; greases for cosmetic purposes; volcanic ash for cleaning; perfumery; decorative transfers for cosmetic purposes; ionone [perfumery]; shaving stones [astringents]; smoothing stones; eyebrow pencils; cosmetic pencils; silicon carbide [abrasive]; carbides of metal [abrasives]; alum stones [astringents]; tripoli stone for polishing; adhesives for affixing false eyelashes; adhesives for affixing false hair; hair conditioners; quillaia bark for washing; corundum [abrasive]; beard dyes; colorants for toilet purposes; cosmetic dyes; laundry starch; laundry glaze; shoe cream; polishing creams; cosmetic creams; skin whitening creams; polishing rouge; incense; hair spray; nail varnish; hair lotions; lotions for cosmetic purposes; after-shave lotions; beauty masks; oils for perfumes and scents; oils for cosmetic purposes; maternity cosmetic oils; oils for toilet purposes; essential oils; essential oils of cedarwood; essential oils of lemon; essential oils of citron; oils for cleaning purposes; bergamot oil; gaultheria oil; jasmine oil; lavender oil; almond oil; rose oil; oil of turpentine for degreasing; whiting; cleaning chalk; almond milk for cosmetic purposes; cleansing milk for toilet purposes; musk [perfumery]; soap; deodorant soap; shaving soap; soap for brightening textile; cakes of toilet soap; antiperspirant soap; soap for foot perspiration; almond soap; mint for perfumery; cosmetic kits; emery; gel eye patches for cosmetic purposes; nail art stickers; false nails; eau de Cologne; extracts of flowers [perfumes]; joss sticks; pastes for razor strops; toothpaste; pumice stone; lipstick cases; hydrogen peroxide for cosmetic purposes; breath freshening strips; teeth whitening strips; sandcloth; glass cloth [abrasive cloth]; lipsticks; pomades for cosmetic purposes; dentifrices; shaving preparations; cosmetic preparations for baths; bath preparations, not for medical purposes; hair straightening preparations; hair waving preparations; laundry soaking preparations; grinding preparations; smoothing preparations [starching]; colour-removing preparations; leather bleaching preparations; polishing preparations; denture polishes; mouthwashes, not for medical purposes; cosmetic preparations for slimming purposes; starch glaze for laundry purposes; preparations to make the leaves of plants shiny; eye-washes, not for medical purposes; fabric softeners for laundry use; laundry bleaching preparations; dry-cleaning preparations; paint stripping preparations; lacquer removing preparations; make-up removing preparations; floor wax removers [scouring preparations]; varnish-removing preparations; rust removing preparations; nail care preparations; cleaning preparations; preparations for cleaning dentures; wallpaper cleaning preparations; preparations for unblocking drain pipes; chemical cleaning preparations for household purposes; collagen preparations for cosmetic purposes; bleaching preparations [decolorants] for household purposes; laundry preparations; aloe vera preparations for cosmetic purposes; sunscreen preparations; colour-brightening chemicals for household purposes [laundry]; breath freshening preparations for personal hygiene; shining preparations [polish]; make-up powder; diamantine [abrasive]; stain removers; nail varnish removers; vaginal washes for personal sanitary or deodorant purposes; scouring solutions; false eyelashes; baby wipes impregnated with cleaning preparations; tissues impregnated with cosmetic lotions; tissues impregnated with make-up removing preparations; safrol; massage candles for cosmetic purposes; laundry blueing; turpentine for degreasing; potpourris [fragrances]; bleaching soda; washing soda, for cleaning; bath salts, not for medical purposes; bleaching salts; fumigation preparations [perfumes]; leather preservatives [polishes]; ammonia [volatile alkali] [detergent]; astringents for cosmetic purposes; eyebrow cosmetics; make-up preparations; sun-tanning preparations [cosmetics]; hair dyes; neutralizers for permanent waving; cosmetic preparations for eyelashes; cosmetic preparations for skin care; shoe wax; cosmetics; maternity care cosmetics; cosmetics for children; cosmetics for animals; cosmetic preparations for skin during pregnancy; mascara; cosmetic preparations for the treatment of skin stretch marks; skin moisturizers used as cosmetics; cleansers for intimate personal hygiene purposes, non medicated; douching preparations for personal sanitary or deodorant purposes [toiletries]; detergents, other than for use in manufacturing operations and for medical purposes; degreasers, other than for use in manufacturing processes; bleaching preparations [decolorants] for cosmetic purposes; toiletry preparations; antiperspirants [toiletries]; phytocosmetic preparations; talcum powder, for toilet use; cotton swabs for cosmetic purposes; terpenes [essential oils]; emery cloth; cloths impregnated with a detergent for cleaning; henna [cosmetic dye]; shampoos; shampoos for animals [non-medicated grooming preparations]; shampoos for pets [non-medicated grooming preparations]; dry shampoos; sandpaper; soda lye; herbal extracts for cosmetic purposes; ethereal essences; badian essence; mint essence [essential oil]. Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; prenatal vitamins, including prenatal vitamins with folic acid; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; sexual stimulant gels; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; gamboge for medical purposes; gurjun balsam for medical purposes; disinfectants; air deodorizing preparations; deodorants, other than for human beings or for animals; deodorants for clothing and textiles; diastase for medical purposes; digitalin; vitamin supplement patches; mineral dietary supplements; dietary supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; haemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine for medical purposes; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; candy for medical purposes; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton swabs for medical purposes; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated toothpaste; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; vitamin and mineral bars for medical purposes; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; diapers for incontinence; bunion pads; breast-nursing pads; pomades for medical purposes; powder of cantharides; pyrethrum powder; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations, including vitamin preparations with folic acid; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; acne treatment preparations; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; bronchodilating preparations; preparations for reducing sexual activity; sterilizing preparations; soil-sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying noxious animals; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; parasiticides; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; styptic preparations; medicated eye-washes; medicinal hair growth preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; sulfonamides [medicines]; pharmaceutical preparations; pharmaceutical preparations for treating sunburn; pharmaceutical preparations for treating dry skin caused by pregnancy; pharmaceutical preparations for preventing skin blemishes during pregnancy; pharmaceutical preparations for the prevention of stretch marks; pharmaceutical preparations for hydrating the skin during pregnancy; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; chilblain preparations; mothproofing preparations; collyrium; lead water; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellents; insect repellent incense; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; suppositories; linseed for pharmaceutical purposes; tobacco free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; medical preparations for slimming purposes; mouthwashes for medical purposes; febrifuges; depuratives; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; purgatives; remedies for perspiration; remedies for foot perspiration; chemical contraceptives; antiparasitic preparations; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; digestives for pharmaceutical purposes; nervines; bouillons for bacteriological cultures; steroids; strychnine; serums; tanning pills; appetite suppressant pills; slimming pills; jujube, medicated; antioxidant pills; sanitary tampons; vulnerary sponges; pregnancy testing preparations for home use; thymol for pharmaceutical purposes; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; smoking herbs for medical purposes; medicinal herbs; transplants [living tissues]; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; jalap.

Abstract

The invention relates to the field of organic chemistry and pharmaceutics and concerns novel compounds of [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate of general structural formula I; a method for the treatment or prophylaxis of functional gastrointestinal disorders, which includes administering to a patient in need thereof an effective amount of the compound of general structural formula I; a pharmaceutical composition based on the compound of general structural formula I; a drug containing the compound of general structural formula I; and a finished dosage form containing the compound of general structural formula I. The invention also relates to the use of the compound of general structural formula I for the treatment or prophylaxis of functional gastrointestinal disorders.

IPC Classes  ?

• C07C 219/14 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
• C07C 219/22 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
• A61K 31/24 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
• A61P 1/06 - Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
• A61P 1/14 - Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; oxygen cylinders, filled, for medical purposes; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; massage gels for medical purposes; sexual stimulant gels; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; contraceptive sponges; gamboge for medical purposes; gurjun balsam for medical purposes; deodorizers for litter trays; deodorants for clothing and textiles; air deodorizing preparations; deodorants, other than for human beings or for animals; diastase for medical purposes; digitalin; vitamin supplement patches; mineral dietary supplements; nutritional supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; brewer's yeast dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; whey protein dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; haemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine for medical purposes; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; cannabis for medical purposes; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; bone void fillers comprised of living tissues; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; aromatic deodorizers for toilets; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton swabs for medical purposes; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated toothpaste; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; swim diapers, reusable, for babies; swim diapers, disposable, for babies; diapers for incontinence; disposable absorbent pads for lining pet crates; diaper changing mats, disposable, for babies; disposable house training pads for pets; bunion pads; breast-nursing pads; diagnostic strips for testing breast milk for medical purposes; pomades for medical purposes; powder of cantharides; pyrethrum powder; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; acne treatment preparations; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; bronchodilating preparations; preparations for reducing sexual activity; sterilizing preparations; soil-sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; vermin destroying preparations; preparations for destroying noxious animals; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; styptic preparations; medicated eye-washes; medicinal hair growth preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; sulfonamides [medicines]; pharmaceutical preparations; pharmaceutical preparations for treating sunburn; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; chilblain preparations; mothproofing preparations; collyrium; lead water; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellents; insect repellent incense; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; crystallized rock sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; medical preparations for slimming purposes; parasiticides; mouthwashes for medical purposes; medicated dentifrices; febrifuges; depuratives; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; purgatives; remedies for perspiration; remedies for foot perspiration; anti-inflammatories; chemical contraceptives; antiparasitic preparations; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; digestives for pharmaceutical purposes; nervines; bouillons for bacteriological cultures; steroids; headache relief sticks; strychnine; suppositories; serums; tanning pills; appetite suppressant pills; slimming pills; jujube, medicated; antioxidant pills; sanitary tampons; vulnerary sponges; tetrahydrocannabidinol [THC] for medical use; thymol for pharmaceutical purposes; smoking herbs for medical purposes; medicinal herbs; transplants [living tissues]; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; bath tea for therapeutic purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; rat poison; poisons; bacterial poisons; jalap; cannabidiol for medical use.

Abstract

The present invention relates to novel biologically active compounds, in particular dicarboxylic acid bisamide derivatives of general formula I: The present invention relates to novel biologically active compounds, in particular dicarboxylic acid bisamide derivatives of general formula I: The present invention relates to novel biologically active compounds, in particular dicarboxylic acid bisamide derivatives of general formula I: or pharmaceutically acceptable salts thereof, which are able to form complexes with or chelate metal ions. The invention also relates to the use of said compounds as an agent for the prevention and/or treatment of cardiovascular, viral, cancer, neurodegenerative and inflammatory diseases, diabetes, age-related diseases, diseases caused by microbial toxins, alcoholism and alcoholic cirrhosis, anaemia, porphyria cutanea tarda, and transition metal salt poisoning. The present invention also relates to novel methods for preparing dicarboxylic acid bisamide derivatives of general formula I.

IPC Classes  ?

• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 233/64 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
• C07D 235/14 - Radicals substituted by nitrogen atoms
• C07D 277/64 - Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
• C07D 277/28 - Radicals substituted by nitrogen atoms
• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links

Goods & Services

Pharmaceuticals for the treatment of cough, pharyngitis, laryngitis and tracheitis; pharmaceutical preparations for the treatment and prevention of viral diseases; pharmaceutical preparations for the prevention and treatment of colds, including pharmaceutical preparations for the prevention and treatment of colds in the form of suspensions; pharmaceuticals for the treatment of eosinophilic diseases and diseases of the upper respiratory conditions; antivirals in the form of tablets, capsules, suspensions and drops; pharmaceutical antitussive-cold preparations.

Goods & Services

Pharmaceutical preparations for the prevention and treatment of vaginal atrophy, decreased libido and sexual dysfunction.

Abstract

The invention relates to the field of medicine, pharmacology and the chemical and pharmaceutical industry, and more particularly to new polymorphic forms and an amorphous phase of 4-aminopyridine, including an active pharmaceutical substance, pharmaceutical formulation and dosage form thereof which can be used for the symptomatic treatment of an impaired gate in a patient having multiple sclerosis.

IPC Classes  ?

• C07D 213/73 - Unsubstituted amino or imino radicals
• A61K 31/4409 - Non-condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61K 9/14 - Particulate form, e.g. powders
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• G03B 42/02 - Obtaining records using waves other than optical waves; Visualisation of such records by using optical means using X-rays

Goods & Services

Balms, other than for medical purposes; vaginal washes for personal sanitary or deodorant purposes; cosmetic preparations for skin care of vulvovaginal zone; cosmetic preparations for skin care of vulva and vagina, non medicated, including in the form of candles with hyaluronic acid; cleansers for intimate personal hygiene purposes, non medicated; douching preparations for personal sanitary or deodorant purposes [toiletries]; moistening candles non medicated for vulvovaginal zone; vaginal moisturizing non-medical preparations. Balms for medical purposes; sexual stimulant gels; lotions for pharmaceutical purposes; personal sexual lubricants; ointments for female external genitals; preparations for the treatment of a symptom of dryness in the genital area; vaginal washes for medical purposes; medical moistening candles for vulvovaginal zone; greases for medical purposes; medical vaginal moisturizing preparations; suppositories; vaginal elixirs [pharmaceutical preparations].

Goods & Services

Antibiotics; germicides; balms for medical purposes; dietetic substances adapted for medical use; vitamin preparations; veterinary preparations; mineral waters for medical purposes; mustard plasters; sanitary preparations for medical purposes; mineral food supplements; food supplements for medical purposes; yeast for pharmaceutical purposes; candy for medical purposes; acids for pharmaceutical purposes; medicated sweets; medicinal roots; starch for dietetic or pharmaceutical purposes; milk sugar for pharmaceutical purposes; medicines for human purposes; lecithin for medical purposes; adhesive plasters; liniments; medicinal oils; dressings, medical; drugs for medical purposes; medicines for veterinary purposes; milk ferments for pharmaceutical purposes; medicinal drinks; dietetic beverages adapted for medical purposes; medicinal infusions; tinctures for medical purposes; albuminous preparations for medical purposes; preparations of trace elements for human and animal use; pharmaceutical preparations; chemico-pharmaceutical preparations; chemical preparations for pharmaceutical purposes; chemical preparations for veterinary purposes; chemical preparations for medical purposes; albuminous foodstuffs for medical purposes; food for babies; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; syrups for pharmaceutical purposes; antiseptics; anaesthetics; disinfectants for hygiene purposes; febrifuges; tonics [medicines]; medical preparations for slimming purposes; medicinal herbs; sedatives; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; herbal teas for medicinal purposes; elixirs [pharmaceutical preparations].

Goods & Services

Pharmaceutical preparations; veterinary preparations; sanitary preparations for medical purposes; dietetic foods adapted for medical purposes; dietetic foods adapted for veterinary purposes; dietetic substances adapted for medical use; dietary supplements for human beings and animals; dressings, medical; petroleum jelly for medical purposes; aseptic cotton; antiseptic cotton; absorbent cotton; wadding for medical purposes; liniments; sunburn ointments; diapers for incontinence; biological preparations for veterinary purposes; biological preparations for medical purposes; chemical preparations for veterinary purposes; sanitary towels; panty liners [sanitary]; chemical reagents for veterinary purposes; sanitary tampons.

Goods & Services

Pharmaceutical preparations for treating musculoskeletal system disorders; pharmaceutical preparations for treating muscle spasms; pharmaceutical preparations for muscle tone reduction; centrally acting muscle relaxants.

Goods & Services

Amino acids for veterinary purposes; amino acids for medical purposes; medicine cases, portable, filled; first-aid boxes, filled; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; petroleum jelly for medical purposes; oxygen baths; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; radioactive substances for medical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre; moulding wax for dentists; gases for medical purposes; sexual stimulant gels; haematogen; haemoglobin; glycerine for medical purposes; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; gurjun balsam for medical purposes; diastase for medical purposes; mineral food supplements; nutritional supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; oxygen for medical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; collagen for medical purposes; corn rings for the feet; medicated sweets; barks for pharmaceutical purposes; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; cultures of microorganisms for medical or veterinary use; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; adhesive plasters; medicines for alleviating constipation; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; frostbite salve for pharmaceutical purposes; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; decoctions for pharmaceutical purposes; stick liquorice for pharmaceutical purposes; pastilles for pharmaceutical purposes; medicated toothpaste; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; diapers for incontinence; bunion pads; breast-nursing pads; pomades for medical purposes; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; acne treatment preparations; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; bronchodilating preparations; preparations for reducing sexual activity; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; medicated eye-washes; medicinal hair growth preparations; nutraceutical preparations for therapeutic or medical purposes; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; pharmaceutical preparations; pharmaceutical preparations for treating sunburn; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemical preparations for medical purposes; chemical preparations for pharmaceutical purposes; chilblain preparations; collyrium; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; vaginal washes for medical purposes; solutions for contact lenses; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; tissues impregnated with pharmaceutical lotions; sugar for medical purposes; asthmatic tea; massage candles for therapeutic purposes; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; syrups for pharmaceutical purposes; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; cooling sprays for medical purposes; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; appetite suppressants for medical purposes; medical preparations for slimming purposes; mouthwashes for medical purposes; febrifuges; depuratives; purgatives; remedies for perspiration; remedies for foot perspiration; chemical contraceptives; laxatives; tonics [medicines]; medicated toiletry preparations; digestives for pharmaceutical purposes; nervines; bouillons for bacteriological cultures; steroids; serums; tanning pills; appetite suppressant pills; slimming pills; smoking herbs for medical purposes; medicinal herbs; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; porcelain for dental prostheses; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; diabetic bread adapted for medical use; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; medicated shampoos; medicated shampoos for pets; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; medicated candies; cotton sticks for medical purposes; cotton swabs for medical purposes; diagnostic preparations for veterinary purposes; vaginal douches for medical purposes; hemostatics for medical purposes; suppositories; milking grease; sedatives; tranquillizers; jujube, medicated; fennel for medical purposes; nutritional supplements containing lactitol.

Goods & Services

Pharmaceuticals for the treatment of cough, pharyngitis, laryngitis and tracheitis; pharmaceutical preparations for the treatment and prevention of viral diseases; pharmaceutical preparations for the treatment and prevention of colds, including preparations in the form of suspensions; pharmaceuticals for the treatment of eosinophilic diseases and diseases of the upper respiratory tract; antivirals in the form of tablets, capsules, suspensions and drops.

Abstract

The present invention relates to medicine and concerns the treatment of diseases associated with aberrant Interleukin-6 activity and the development of cytokine release (cytokine storm) syndrome, preferably the treatment of COVID-19, as well as other diseases complicated by aberrant Interleukin-6 activity and the development of cytokine release syndrome, using the compound 1-(2-(1-methyl-1Н-imidazol-4-yl)ethyl)piperidine-2,6-dione (formula I). The invention provides for the creation of a novel effective drug for treating diseases associated with the development of cytokine release syndrome.

IPC Classes  ?

• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 39/42 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
• C07J 5/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, and substituted in position 21 by only one singly bound oxygen atom
• A61P 31/14 - Antivirals for RNA viruses
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Goods & Services

Dietetic substances adapted for medical use; vitamin preparations; dietary and nutritional supplements; pharmaceutical preparations; pharmaceuticals.

Abstract

The invention relates to the therapy of diseases associated with the activity of histamine receptors, in particular for the treatment of allergic diseases, preferably the therapy of perennial and persistent allergic rhinitis, itch, as well as a number of other diseases associated with the activity of histamine receptor type 3 and/or 4, using compound N,N′-bis(2-(1H-imidazol-5-yl)ethyl)malonamide. This compound, as well as pharmaceutically acceptable salts, hydrates, or solvates thereof, is an antagonist of histamine receptor type 3 and/or 4. The invention also relates to pharmaceutical compositions containing a therapeutically effective amount of Compound I.

IPC Classes  ?

• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61P 37/08 - Antiallergic agents
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The invention relates to the field of organic chemistry and pharmacy and provides a novel compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2Н-chromen-2-on-7-yl sulphate, a method for treating and preventing functional gastrointestinal disorders, which comprises administering an effective amount of compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2Н-chromen-2-on-7-yl sulphate to a patient in need thereof, a pharmaceutical composition based on compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2Н-chromen-2-on-7-yl sulphate, a drug comprising compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2Н-chromen-2-on-7-yl sulphate, and a finished dosage form comprising compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2Н-chromen-2-on-7-yl sulphate. The invention further relates to the use of compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2Н-chromen-2-on-7-yl sulphate for treating and preventing functional gastrointestinal disorders.

IPC Classes  ?

• C07C 219/22 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
• C07D 311/16 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
• A61K 31/24 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 1/06 - Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
• A61P 1/08 - Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
• A61P 1/12 - Antidiarrhoeals
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 1/18 - Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes

Abstract

The invention relates to the chemical and pharmaceutical industry and medicine and concerns a novel pharmaceutical composition comprising mirtazapine and tizanidine or pharmaceutically acceptable salts thereof, for treating pain disorders, said composition being characterized in that the mirtazapine content ranges from 15 to 60 mg and the tizanidine content ranges from 6 to 24 mg, wherein the mass ratio of mirtazapine to tizanidine as free bases is 2.5:1. The invention also relates to a pharmaceutical combination, a therapeutic drug, to the use thereof and to a method for treating a pain disorder.

IPC Classes  ?

• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 31/433 - Thiadiazoles
• A61K 9/24 - Layered or laminated unitary dosage forms
• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
• A61P 25/04 - Centrally acting analgesics, e.g. opioids

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; sexual stimulant gels; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; gamboge for medical purposes; gurjun balsam for medical purposes; disinfectants; air deodorizing preparations; deodorants, other than for human beings or for animals; deodorants for clothing and textiles; diastase for medical purposes; digitalin; vitamin supplement patches; mineral food supplements; nutritional supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; haemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; medicated candies; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton swabs for medical purposes; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated toothpaste; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; diapers for incontinence; bunion pads; breast-nursing pads; pomades for medical purposes; powder of cantharides; pyrethrum powder; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; acne treatment preparations; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; bronchodilating preparations; preparations for reducing sexual activity; sterilizing preparations; soil-sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying noxious animals; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; vermin destroying preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; styptic preparations; medicated eye-washes; medicinal hair growth preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; sulfonamides [medicines]; pharmaceutical preparations; pharmaceutical preparations for treating sunburn; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; chilblain preparations; mothproofing preparations; collyrium; lead water; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellents; insect repellent incense; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; medical preparations for slimming purposes; parasiticides; mouthwashes for medical purposes; febrifuges; depuratives; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; purgatives; remedies for perspiration; remedies for foot perspiration; chemical contraceptives; antiparasitic preparations; laxatives; tonics [medicines]; medicated toiletry preparations; digestives for pharmaceutical purposes; nervines; bouillons for bacteriological cultures; steroids; strychnine; serums; tanning pills; appetite suppressant pills; slimming pills; antioxidant pills; sanitary tampons; vulnerary sponges; thymol for pharmaceutical purposes; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; smoking herbs for medical purposes; medicinal herbs; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; rat poison; poisons; bacterial poisons; jalap; suppositories; milking grease; sedatives; jujube, medicated; fennel for medical purposes; cellulose ethers for pharmaceutical purposes; vitamins; pharmaceuticals for the treatment of diseases of the nervous system; pharmaceuticals for the treatment of neurological diseases, including pharmaceuticals for the treatment of polyneuropathy; pharmaceuticals for treating neuralgia; pharmaceuticals for the treatment of lumboischialgia; pharmaceuticals for the treatment of radiculopathy; pharmaceuticals for the treatment of cervicobrachial syndrome; pharmaceuticals for the treatment of radicular syndrome; pharmaceuticals for the treatment of neuritis.

Abstract

The invention relates to the field of medicine, pharmacology and the chemical and pharmaceutical industry, and more particularly to novel compounds of general formula (I), and optical isomers and pharmaceutically acceptable salts thereof, a pharmaceutical composition based on compounds of general formula (I) or optical isomers or pharmaceutically acceptable salts thereof, and a drug based on said compounds of general formula (I) or optical isomers or pharmaceutically acceptable salts thereof, or on said pharmaceutical composition. The invention also relates to the use of said compounds of general formula (I) or optical isomers or pharmaceutically acceptable salts thereof, or of said pharmaceutical composition, or of said drug for the treatment and/or prophylaxis of respiratory diseases.

IPC Classes  ?

• C07D 233/64 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/4172 - Imidazole-alkanecarboxylic acids, e.g. histidine
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• A61P 31/12 - Antivirals
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
• A61P 11/00 - Drugs for disorders of the respiratory system

Goods & Services

Alkaloids for medical purposes; alginates for pharmaceutical purposes; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; balms for medical purposes; bromine for pharmaceutical purposes; petroleum jelly for medical purposes; vaccines; oxygen baths; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; seawater for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fibre; moulding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; haematogen; haemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mud for baths; medicinal mud; gamboge for medical purposes; gurjun balsam for medical purposes; diastase for medical purposes; digitalin; mineral food supplements; nutritional supplements; albumin dietary supplements; dietary supplements for animals; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; haemostatic pencils; wart pencils; caustic pencils; headache relief sticks; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; stem cells for veterinary purposes; stem cells for medical purposes; cocaine; collodion for pharmaceutical purposes; corn rings for the feet; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; milk sugar for pharmaceutical purposes; medicated candies; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; dog lotions; lotions for pharmaceutical purposes; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; decoctions for pharmaceutical purposes; antiparasitic collars for animals; stick liquorice for pharmaceutical purposes; pastilles for pharmaceutical purposes; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; leeches for medical purposes; blood plasma; pomades for medical purposes; anti-uric preparations; bacterial preparations for medical use; bacteriological preparations for medical use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for medical purposes; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for medical purposes; therapeutic preparations for the bath; haemorrhoid preparations; preparations for callouses; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; eye-washes; bronchodilating preparations; preparations for reducing sexual activity; sterilizing preparations; corn remedies; pharmaceutical preparations for treating dandruff; pharmaceutical preparations for skin care; lime-based pharmaceutical preparations; medicinal hair growth preparations; opiates; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; sulfonamides [medicines]; pharmaceutical preparations; drugs to reduce and prevent withdrawal syndrome, including for persons with alcohol, nicotine and drug addiction; pharmaceutical preparations for treating sunburn; enzyme preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for pharmaceutical purposes; chilblain preparations; collyrium; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; vaginal washes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; chewing gum for medical purposes; sarsaparilla for medical purposes; sugar for medical purposes; asthmatic tea; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; greases for medical purposes; soporifics; bicarbonate of soda for pharmaceutical purposes; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; malt for pharmaceutical purposes; alcohol for pharmaceutical purposes; medicinal alcohol; ergot for pharmaceutical purposes; cooling sprays for medical purposes; adjuvants for medical purposes; styptic preparations; vermifuges; douching preparations for medical purposes; appetite suppressants for medical purposes; medical preparations for slimming purposes; mouthwashes for medical purposes; febrifuges; depuratives; vesicants; purgatives; chemical contraceptives; antiparasitic preparations; sedatives; laxatives; tonics [medicines]; nervines; digestives for pharmaceutical purposes; bouillons for bacteriological cultures; strychnine; suppositories; serums; tanning pills; appetite suppressant pills; slimming pills; antioxidant pills; thymol for pharmaceutical purposes; biological tissue cultures for medical purposes; smoking herbs for medical purposes; medicinal herbs; charcoal for pharmaceutical purposes; fennel for medical purposes; phenol for pharmaceutical purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; quinine for medical purposes; chinoline for medical purposes; chloroform; flowers of sulfur for pharmaceutical purposes; medicinal tea; herbal teas for medicinal purposes; eucalyptus for pharmaceutical purposes; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; jujube, medicated; jalap.

Abstract

The invention relates to the field of medicine, pharmacology and the chemical pharmaceutical industry, more particularly to novel compositions for the treatment and prophylaxis of diseases of the respiratory tract, the compositions comprising pentane-1,5-dioic acid 2-(imidazol-4-yl)ethanamide and N,N'-bis-[2-(1H-imidazol-4-yl)ethyl]pentanediamide and/or pharmaceutically acceptable salts thereof, a pharmaceutical formulation based on said compositions, a medicament based on said compositions or said pharmaceutical formulation, and a finished dosage form based on said compositions, said pharmaceutical formulation or said medicament. The invention also relates to the use of the aforementioned compositions, the pharmaceutical formulation, the medicament or the finished dosage form for the treatment and prophylaxis of diseases of the respiratory tract.

IPC Classes  ?

• A61K 38/05 - Dipeptides
• A61K 31/4172 - Imidazole-alkanecarboxylic acids, e.g. histidine
• A61P 11/00 - Drugs for disorders of the respiratory system

Goods & Services

Antibiotics; germicides; balms for medical purposes; dietetic substances adapted for medical use; vitamin preparations; veterinary preparations; mineral waters for medical purposes; mustard plasters; sanitary preparations for medical purposes; mineral food supplements; nutritional supplements; yeast for pharmaceutical purposes; medicated candies; acids for pharmaceutical purposes; medicated sweets; medicinal roots; starch for dietetic or pharmaceutical purposes; lactose for pharmaceutical purposes; lecithin for medical purposes; adhesive plasters; liniments; medicinal oils; dressings, medical; drugs for medical purposes; medicines for human purposes; medicines for veterinary purposes; milk ferments for pharmaceutical purposes; medicinal drinks; dietetic beverages adapted for medical purposes; medicinal infusions; tinctures for medical purposes; albuminous preparations for medical purposes; preparations of trace elements for human and animal use; pharmaceutical preparations; chemico-pharmaceutical preparations; chemical preparations for pharmaceutical purposes; chemical preparations for veterinary purposes; chemical preparations for medical purposes; albuminous foodstuffs for medical purposes; food for babies; dietetic foods adapted for medical purposes; by-products of the processing of cereals for medical purposes; syrups for pharmaceutical purposes; antiseptic preparations; analgesic preparations; disinfectants for hygiene purposes; febrifuges; tonics [medicines]; medical preparations for slimming purposes; medicinal herbs; sedatives; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; herbal teas for medicinal purposes; elixirs [pharmaceutical preparations].

Goods & Services

Pharmaceutical preparations for the treatment of autoimmune diseases and diseases accompanied by movement disorders, including multiple sclerosis; pharmaceuticals for the symptomatic treatment of walking disorders in patients with multiple sclerosis.

Abstract

The invention relates to the field of medicine, pharmacology, and the chemical and pharmaceutical industry, and specifically to a novel combination comprising, in effective quantities, trimebutine or a pharmaceutically acceptable salt thereof with at least one substance selected from the group including 4-oxo-4-(2,4,5-triethoxyphenyl)butyric acid, 4-(5-cyclohexyl-2,4-dimethoxyphenyl)-4-oxobutyric acid, 4-methyl-7-sulfoxycoumarin, and 2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propionic acid, and pharmaceutically acceptable salts thereof. The invention is a versatile and effective agent for treating functional diseases of organs of the gastrointestinal tract.

IPC Classes  ?

• A61K 31/24 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
• A61P 1/06 - Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
• A61P 1/14 - Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antidepressants; anti-oxidants for use as dietary supplements; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; sea water for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fiber, including for treating constipation; molding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; sexual stimulant gels; hematogen; hemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; gamboge for medical purposes; gurjun balsam for medical purposes; disinfectants; deodorants, other than for human beings or for animals; air deodorising preparations; deodorants for clothing and textiles; diastase for medical purposes; digitalin; vitamin supplement patches; mineral food supplements; dietary and nutritional supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; cream of tartar for pharmaceutical purposes; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; hemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; medicated sweets; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; lactose for pharmaceutical purposes; candy for medical purposes; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; frostbite salve for pharmaceutical purposes; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; nootropics; opium; opodeldoc; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton sticks for medical purposes; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated dentifrices; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; diapers for incontinence; breast-nursing pads; bunion pads; pomades for medical purposes; powder of cantharides; pyrethrum powder; chilblain preparations; mothproofing preparations; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; veterinary preparations for treatment of intestinal bacteria; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; pharmaceutical preparations for memory consolidation; hemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; cardiovascular treatment preparations; acne treatment preparations; preparations for alcohol addiction; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; preparations for improving physical and mental performance, stress tolerance; preparations for hypoxia prophylaxis; bronchodilating preparations; preparations for reducing sexual activity; sterilising preparations; soil-sterilising preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying noxious animals; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; vermin destroying preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; lime-based pharmaceutical preparations; preparations of microorganisms for medical or veterinary use; styptic preparations; medicated eye-washes; medicinal hair growth preparations; fonturacetam-based preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; preparations for obesity; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; purgative preparations; central nervous system stimulants; sulfonamides [medicines]; pharmaceutical preparations for the treatment of digestive diseases; pharmaceutical preparations for the treatment of cardiovascular diseases; pharmaceutical preparations for treating sunburn; pharmaceutical preparations for the treatment of central nervous system [CNS] diseases; pharmaceutical preparations for the central nervous system; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; collyrium; lead water; probiotic preparations for medical purposes to help maintain a natural balance of flora in the digestive system; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; anticonvulsants; pearl powder for medical purposes; radium for medical purposes; solvents for removing adhesive plasters; hydrated chloral for pharmaceutical purposes; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellents; insect repellent incense; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; suppositories; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; mineral water salts; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; digestives for pharmaceutical purposes; nervines; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; medical preparations for slimming purposes; parasiticides; mouthwashes for medical purposes; febrifuges; depuratives; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; purgatives; chemical contraceptives; antiparasitic preparations; remedies for perspiration; remedies for foot perspiration; psychotropics; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; media for bacteriological cultures; steroids; strychnine; serums; antioxidant pills; tanning pills; appetite suppressant pills; slimming pills; jujube, medicated; sanitary tampons; vulnerary sponges; thymol for pharmaceutical purposes; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; smoking herbs for medical purposes; medicinal herbs; transplants [living tissues]; surgical implants comprised of living tissues; babies' diaper-pants; pants, absorbent, for incontinence; sanitary panties; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; rat poison; poisons; bacterial poisons; jalap.

Abstract

The invention relates to the chemical and pharmaceutical industry and to medicine, and concerns a novel liquid dosage form for oral administration for the treatment and prophylaxis of influenza and acute viral respiratory tract infections, said dosage form comprising 2-(imidazol-4-yl)-ethanamide pentanedioic-1,5 acid in an effective amount, and excipients.

IPC Classes  ?

• A61K 31/417 - Imidazole-alkylamines, e.g. histamine, phentolamine
• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
• A61K 9/08 - Solutions
• A61P 31/12 - Antivirals

Goods & Services

Antibiotics; medicines for human purposes; pharmaceutical preparations; chemico-pharmaceutical preparations; chemical preparations for pharmaceutical purposes.

Abstract

The invention relates to chemistry of organic substances, pharmacology and medicine, and concerns treating diseases associated and with aberrant activity of cells of the immune system, more particularly for treating lung, respiratory tract and abdominal diseases, radiation sickness and pain syndrome, and also other diseases by using compounds of formula (A) wherein compounds are selected from the group consisting of the group of compounds as set out in the description. These compounds, as well as pharmaceutically acceptable salts thereof, are highly effective in inhibiting glutaminyl cyclase, which is involved, in particular, in processes of post-translational modification of chemokines and chemotaxis of monocytes, macrophages and other cells of the immune system. This invention also relates to pharmaceutical compositions comprising a therapeutically effective amount of the compounds of formula (A) as defined above.

IPC Classes  ?

• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 17/06 - Antipsoriatics
• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 3/04 - Anorexiants; Antiobesity agents
• A61P 11/06 - Antiasthmatics
• A61P 17/00 - Drugs for dermatological disorders
• C12N 9/10 - Transferases (2.)

Abstract

Proposed are novel compositions containing N-carbamoylmethyl-4-phenyl-2-pyrrolidone and at least one additional compound selected from the group containing 4-phenyl pyrrolidone-2,2-(2-oxo-4-phenyl pyrrolidin-1-yl) acetic acid, ethyl-2-(2-oxo-4-phenyl pyrrolidin-1-yl) acetate, and optical isomers thereof, said compositions having lower hygroscopicity and greater stability than the known substance fonturacetam; as well as a pharmaceutical formulation based on said composition and a drug based on said pharmaceutical formulation.

IPC Classes  ?

• A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Goods & Services

Acaricides; aconitine; alkaloids for medical purposes; alginates for pharmaceutical purposes; algicides; aldehydes for pharmaceutical purposes; dental amalgams of gold; dental amalgams; amino acids for veterinary purposes; amino acids for medical purposes; analgesics; anaesthetics; antibiotics; antiseptics; medicine cases, portable, filled; first-aid boxes, filled; aluminium acetate for pharmaceutical purposes; acetates for pharmaceutical purposes; germicides; balms for medical purposes; bandages for dressings; diagnostic biomarker reagents for medical purposes; biocides; bracelets impregnated with insect repellent; bromine for pharmaceutical purposes; paper for mustard plasters; fly catching paper; reagent paper for veterinary purposes; reagent paper for medical purposes; mothproofing paper; petroleum jelly for medical purposes; vaccines; oxygen baths; antiseptic cotton; aseptic cotton; absorbent cotton; wadding for medical purposes; cotton for medical purposes; dietetic substances adapted for medical use; radiological contrast substances for medical purposes; nutritive substances for microorganisms; radioactive substances for medical purposes; bismuth subnitrate for pharmaceutical purposes; melissa water for pharmaceutical purposes; sea water for medicinal bathing; mineral waters for medical purposes; thermal water; dietary fiber; molding wax for dentists; gases for medical purposes; guaiacol for pharmaceutical purposes; sexual stimulant gels; hematogen; hemoglobin; hydrastine; hydrastinine; glycerine for medical purposes; glycerophosphates; glucose for medical purposes; gentian for pharmaceutical purposes; hormones for medical purposes; mustard for pharmaceutical purposes; mustard plasters; mud for baths; medicinal mud; gamboge for medical purposes; gurjun balsam for medical purposes; disinfectants; air deodorising preparations; deodorants, other than for human beings or for animals; deodorants for clothing and textiles; diastase for medical purposes; digitalin; vitamin supplement patches; mineral food supplements; nutritional supplements; albumin dietary supplements; dietary supplements for animals; yeast dietary supplements; alginate dietary supplements; glucose dietary supplements; casein dietary supplements; lecithin dietary supplements; linseed oil dietary supplements; propolis dietary supplements; protein dietary supplements; protein supplements for animals; royal jelly dietary supplements; pollen dietary supplements; wheat germ dietary supplements; linseed dietary supplements; acai powder dietary supplements; dietary supplements with a cosmetic effect; enzyme dietary supplements; yeast for pharmaceutical purposes; gelatine for medical purposes; cod liver oil; isotopes for medical purposes; immunostimulants; insecticides; iodine for pharmaceutical purposes; iodides for pharmaceutical purposes; alkaline iodides for pharmaceutical purposes; iodoform; calomel [fungicide]; tartar for pharmaceutical purposes; camphor for medical purposes; capsules for medicines; cachets for pharmaceutical purposes; capsules made of dendrimer-based polymers, for pharmaceuticals; hemostatic pencils; wart pencils; caustic pencils; carbolineum [parasiticide]; caustics for pharmaceutical purposes; cachou for pharmaceutical purposes; quassia for medical purposes; quebracho for medical purposes; oxygen for medical purposes; gallic acid for pharmaceutical purposes; acids for pharmaceutical purposes; adhesives for dentures; surgical glues; stem cells for veterinary purposes; stem cells for medical purposes; cocaine; collagen for medical purposes; collodion for pharmaceutical purposes; corn rings for the feet; candy, medicated; angostura bark for medical purposes; barks for pharmaceutical purposes; cedar wood for use as an insect repellent; condurango bark for medical purposes; croton bark; mangrove bark for pharmaceutical purposes; myrobalan bark for pharmaceutical purposes; quinquina for medical purposes; medicated animal feed; medicinal roots; rhubarb roots for pharmaceutical purposes; lint for medical purposes; starch for dietetic or pharmaceutical purposes; creosote for pharmaceutical purposes; blood for medical purposes; cultures of microorganisms for medical or veterinary use; curare; dental lacquer; liquorice for pharmaceutical purposes; lactose for pharmaceutical purposes; candy for medical purposes; adhesive plasters; medicines for alleviating constipation; adhesive tapes for medical purposes; lecithin for medical purposes; lotions for veterinary purposes; medicated hair lotions; lotions for pharmaceutical purposes; medicated after-shave lotions; personal sexual lubricants; lupulin for pharmaceutical purposes; magnesia for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; sunburn ointments; mercurial ointments; frostbite salve for pharmaceutical purposes; gauze for dressings; medicinal oils; mustard oil for medical purposes; camphor oil for medical purposes; castor oil for medical purposes; oil of turpentine for pharmaceutical purposes; dill oil for medical purposes; dental mastics; dental abrasives; dental impression materials; teeth filling material; dressings, medical; surgical dressings; drugs for medical purposes; medicines for veterinary purposes; serotherapeutic medicines; medicines for human purposes; medicines for dental purposes; menthol; medicinal drinks; moleskin for medical purposes; almond milk for pharmaceutical purposes; powdered milk for babies; royal jelly for pharmaceutical purposes; milk ferments for pharmaceutical purposes; Irish moss for medical purposes; flour for pharmaceutical purposes; linseed meal for pharmaceutical purposes; fish meal for pharmaceutical purposes; fly glue; antibacterial soap; disinfectant soap; medicated soap; freeze-dried meat adapted for medical purposes; mint for pharmaceutical purposes; dietetic beverages adapted for medical purposes; malted milk beverages for medical purposes; injectable dermal fillers; narcotics; medicinal infusions; tincture of iodine; eucalyptol for pharmaceutical purposes; tinctures for medical purposes; opium; opodeldoc; decoctions for pharmaceutical purposes; antiparasitic collars for animals; cotton sticks for medical purposes; stick liquorice for pharmaceutical purposes; sulfur sticks [disinfectants]; pastilles for pharmaceutical purposes; medicated dentifrices; pectin for pharmaceutical purposes; pepsins for pharmaceutical purposes; peptones for pharmaceutical purposes; hydrogen peroxide for medical purposes; pesticides; food for babies; leeches for medical purposes; blood plasma; nicotine patches for use as aids to stop smoking; eyepatches for medical purposes; poultices; compresses; scapulars for surgical purposes; babies' diapers; diapers for pets; diapers for incontinence; bunion pads; breast-nursing pads; pomades for medical purposes; powder of cantharides; pyrethrum powder; anti-uric preparations; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; balsamic preparations for medical purposes; albuminous preparations for medical purposes; biological preparations for veterinary purposes; biological preparations for medical purposes; veterinary preparations; bismuth preparations for pharmaceutical purposes; vitamin preparations; diagnostic preparations for veterinary purposes; diagnostic preparations for medical purposes; douching preparations for medical purposes; bath preparations for medical purposes; therapeutic preparations for the bath; hemorrhoid preparations; preparations for callouses; lice treatment preparations [pediculicides]; acne treatment preparations; preparations to facilitate teething; preparations for the treatment of burns; fumigation preparations for medical purposes; opotherapy preparations; air purifying preparations; bronchodilating preparations; preparations for reducing sexual activity; sterilising preparations; soil-sterilising preparations; corn remedies; pharmaceutical preparations for treating dandruff; preparations for destroying noxious animals; herbicides; preparations for destroying dry rot fungus; larvae exterminating preparations; fly destroying preparations; preparations for destroying mice; slug exterminating preparations; vermin destroying preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; preparations of microorganisms for medical or veterinary use; lime-based pharmaceutical preparations; styptic preparations; medicated eye-washes; medicinal hair growth preparations; nutraceutical preparations for therapeutic or medical purposes; opiates; anticryptogamic preparations; aloe vera preparations for pharmaceutical purposes; preparations of trace elements for human and animal use; sulfonamides [medicines]; pharmaceutical preparations; pharmaceutical preparations for treating sunburn; enzyme preparations for veterinary purposes; enzyme preparations for medical purposes; phytotherapy preparations for medical purposes; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for the diagnosis of pregnancy; chemical preparations for medical purposes; chemical preparations for treating diseases affecting cereal plants; chemical preparations for treating wheat blight; chemical preparations for treating diseases affecting vine plants; chemical preparations for treating mildew; chemical preparations for treating phylloxera; chemical preparations for pharmaceutical purposes; chilblain preparations; mothproofing preparations; collyrium; lead water; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; dietetic foods adapted for medical purposes; by-products of the processing of cereals for dietetic or medical purposes; homogenized food adapted for medical purposes; freeze-dried food adapted for medical purposes; pharmaceuticals; sanitary towels; panty liners [sanitary]; propolis for pharmaceutical purposes; pearl powder for medical purposes; radium for medical purposes; hydrated chloral for pharmaceutical purposes; solvents for removing adhesive plasters; vaginal washes for medical purposes; solutions for contact lenses; chemical reagents for medical or veterinary purposes; gum for medical purposes; rubber for dental purposes; chewing gum for medical purposes; nicotine gum for use as an aid to stop smoking; insect repellents; insect repellent incense; repellents for dogs; tissues impregnated with pharmaceutical lotions; sarsaparilla for medical purposes; sugar for medical purposes; asthmatic tea; fumigating sticks; massage candles for therapeutic purposes; suppositories; linseed for pharmaceutical purposes; tobacco-free cigarettes for medical purposes; siccatives [drying agents] for medical purposes; syrups for pharmaceutical purposes; turpentine for pharmaceutical purposes; milking grease; greases for veterinary purposes; greases for medical purposes; lacteal flour for babies; infant formula; soporifics; bicarbonate of soda for pharmaceutical purposes; bath salts for medical purposes; salts for mineral water baths; salts for medical purposes; potassium salts for medical purposes; sodium salts for medical purposes; smelling salts; mineral water salts; malt for pharmaceutical purposes; semen for artificial insemination; alcohol for pharmaceutical purposes; medicinal alcohol; alloys of precious metals for dental purposes; ergot for pharmaceutical purposes; cooling sprays for medical purposes; antibacterial handwashes; adjuvants for medical purposes; astringents for medical purposes; vermifuges; disinfectants for hygiene purposes; disinfectants for chemical toilets; appetite suppressants for medical purposes; medical preparations for slimming purposes; parasiticides; mouthwashes for medical purposes; febrifuges; depuratives; animal washes [insecticides]; detergents for medical purposes; cattle washes [insecticides]; dog washes [insecticides]; insecticidal veterinary washes; vesicants; purgatives; remedies for perspiration; remedies for foot perspiration; chemical contraceptives; antiparasitic preparations; sedatives; laxatives; tonics [medicines]; medicated toiletry preparations; digestives for pharmaceutical purposes; nervines; media for bacteriological cultures; steroids; strychnine; serums; tanning pills; appetite suppressant pills; slimming pills; jujube, medicated; antioxidant pills; sanitary tampons; vulnerary sponges; thymol for pharmaceutical purposes; biological tissue cultures for veterinary purposes; biological tissue cultures for medical purposes; smoking herbs for medical purposes; medicinal herbs; transplants [living tissues]; surgical implants comprised of living tissues; pants, absorbent, for incontinence; sanitary panties; babies' diaper-pants; charcoal for pharmaceutical purposes; fennel for medical purposes; porcelain for dental prostheses; phenol for pharmaceutical purposes; enzymes for veterinary purposes; enzymes for medical purposes; ferments for pharmaceutical purposes; formic aldehyde for pharmaceutical purposes; phosphates for pharmaceutical purposes; fungicides; quinine for medical purposes; chinoline for medical purposes; diabetic bread adapted for medical use; chloroform; flowers of sulfur for pharmaceutical purposes; cement for animal hooves; bone cement for surgical and orthopaedic purposes; dental cements; medicinal tea; herbal teas for medicinal purposes; insecticidal animal shampoos; medicated shampoos; medicated shampoos for pets; pediculicidal shampoos; medicated dry shampoos; pre-filled syringes for medical purposes; eucalyptus for pharmaceutical purposes; herbal extracts for medical purposes; plant extracts for pharmaceutical purposes; tobacco extracts [insecticides]; extracts of hops for pharmaceutical purposes; elixirs [pharmaceutical preparations]; ethers for pharmaceutical purposes; esters for pharmaceutical purposes; cellulose esters for pharmaceutical purposes; cellulose ethers for pharmaceutical purposes; rat poison; poisons; bacterial poisons; jalap; dietary supplements; pharmaceutical preparations for cold and acute respiratory disease symptom control.

Goods & Services

Drugs for medical purposes; medicines for human purposes; pharmaceutical preparations; chemico-pharmaceutical preparations.

Goods & Services

Breath freshening sprays; balms, other than for medical purposes; cosmetic bath salts; petroleum jelly for cosmetic purposes; cotton wool for cosmetic purposes; sachets for perfuming linen; adhesives for cosmetic purposes; depilatory wax; massage gels, other than for medical purposes; dental bleaching gels; make-up; deodorants for human beings or for animals; greases for cosmetic purposes; perfumery; cosmetic creams; hair spray; lotions for cosmetic purposes; beauty masks; oils for cosmetic purposes; cleansing milk for toilet purposes; soap; nail art stickers; dentifrices; cosmetic preparations for slimming purposes; sunscreen preparations; tissues impregnated with cosmetic lotions; cosmetics; sanitary preparations being toiletries; shampoos; ethereal essences. Balms for medical purposes; barks for pharmaceutical purposes; bath salts for medical purposes; wadding for medical purposes; dietetic substances adapted for medical use; mineral waters for medical purposes; mineral food supplements; nutritional supplements; capsules for medicines; candy, medicated; adhesive plasters; lotions for pharmaceutical purposes; liniments; medicinal oils; dressings, medical; drugs for medical purposes; medicinal drinks; food for babies; babies' diapers; breast-nursing pads; pomades for medical purposes; preparations to facilitate teething; pharmaceutical preparations; chemico-pharmaceutical preparations; sanitary towels; tissues impregnated with pharmaceutical lotions; syrups for pharmaceutical purposes; chewing gum for medical purposes; disinfectants for hygiene purposes; medicinal tea.

Goods & Services

Balms, other than for medical purposes; petroleum jelly for cosmetic purposes; massage gels, other than for medical purposes; body deodorants [perfumery]; greases for cosmetic purposes; cosmetic creams; beauty masks; oils for cosmetic purposes; soap; dentifrices; tissues impregnated with cosmetic lotions; cosmetics; shampoos; herbal extracts for cosmetic purposes. Balms for medical purposes; bandages for dressings; bracelets impregnated with insect repellent; paper for mustard plasters; wadding for medical purposes; dietetic substances adapted for medical use; mustard plasters; candy, medicated; wart pencils; caustic pencils; adhesive plasters; medicated hair lotions; liniments; medicinal oils; dressings, medical; drugs for medical purposes; medicated soap; medicated dentifrices; compresses; bunion pads; pomades for medical purposes; sanitary towels; chewing gum for medical purposes; disinfectants for hygiene purposes; medicinal tea; medicated shampoos.

Goods & Services

Pharmaceutical preparations; dietetic substances adapted for medical use; medical plasters; materials for dressings.

Goods & Services

Dietetic substances adapted for medical use; nutritional supplements; mineral food supplements; candy, medicated; adhesive plasters; ointments for pharmaceutical purposes; drugs for medical purposes; medicines for human purposes; dietetic beverages adapted for medical purposes; medicinal infusions; tinctures for medical purposes; decoctions for pharmaceutical purposes; pastilles for pharmaceutical purposes; food for babies; pomades for medical purposes; dietetic foods adapted for medical purposes; pharmaceuticals; chewing gum for medical purposes; syrups for pharmaceutical purposes; digestives for pharmaceutical purposes; medicinal herbs; herbal teas for medicinal purposes.

Goods & Services

Nutritional supplements for medical purposes; pharmaceutical preparations; chemico-pharmaceutical preparations.

Abstract

The invention relates to the pharmaceutical field, specifically to the use of lactitol in a therapeutically effective amount, preferably in a dosage of 1-20 g per day, for the treatment and prophylaxis of non-alcoholic fatty liver disease in a mammal in need thereof. The invention provides for an extension in the range of means effective in relation to the treatment and prophylaxis of non-alcoholic fatty liver disease.

IPC Classes  ?

• A61K 31/7032 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention relates to the field of medicine and pharmacology, and more particularly to novel combinations of buspirone and at least one substance selected from the group consisting of betahistine and piracetam, for treating vestibular and non-vestibular dizziness.

IPC Classes  ?

• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/4402 - Non-condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
• A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
• A61P 1/08 - Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Abstract

The present invention relates to the field of medicine and pharmacology, specifically to new acetylleucine combinations having at least one substance selected from the group consisting of betahistine, buspirone, choline alfoscerate, and citicoline, for treating vestibular and non-vestibular dizziness, cerebellar ataxia, and familial ataxia.

IPC Classes  ?

• A61K 31/198 - Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
• A61K 31/4402 - Non-condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/685 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• A61P 1/08 - Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The invention relates to the field of medicine, pharmacology, and the chemical and pharmaceutical industry, specifically to novel polymorphic forms of trimebutine maleate and methods of producing and using same.

IPC Classes  ?

• A61K 31/24 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
• C07C 219/18 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
• A61P 1/06 - Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia

Abstract

The present invention relates to a combination of edaravone with at least one substance selected from the group consisting of ebselen, resveratrol, uric acid, dehydroascorbic acid and disufenton sodium for the treatment of acute cerebrovascular accident (ACVA) (ischemic stroke) with the aim of decreasing neurological symptoms and decreasing impairment of the patient's performance of everyday activities, as well as decreasing the CNS function impairment associated with stroke; amyotrophic lateral sclerosis (ALS), with the aim of slowing the progression of CNS functional impairments; transitory ischemic attack (TIA), in the acute period and after the attack has occurred; chronic cerebral ischemia; and cognitive and behavioral disorders in the case of cerebrovascular diseases.

IPC Classes  ?

• A61K 31/4152 - 1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
• A61K 31/375 - Ascorbic acid, i.e. vitamin C; Salts thereof
• A61K 31/05 - Phenols
• A61K 31/41 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
• A61K 31/185 - Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The invention relates to the field of medicine and pharmacology, and specifically to a new pharmaceutical combination and a novel medicine kit for providing an anxiolytic effect and includes phenazepam, vitamin B6 and magnesium in effective quantities. The aim of this invention is to create a highly effective complex preparation that provides an anxiolytic effect, has minimal side effects and is suitable for the treating a broad range of anxiety disorders. The technical result is to synergistically enhance the anxiolytic effect of phenazepam in combination with magnesium and vitamin B6 while simultaneously decreasing the side effects of phenazepam in said combination.

IPC Classes  ?

• A61K 31/5513 - 1,4-Benzodiazepines, e.g. diazepam
• A61K 31/4415 - Pyridoxine, i.e.vitamin B6
• A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
• A61K 33/06 - Aluminium, calcium or magnesium; Compounds thereof
• A61K 9/20 - Pills, lozenges or tablets
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The invention relates to the field of medicine and pharmacology, and specifically to a novel use of buspirone or a pharmaceutically acceptable salt thereof for treating functional dizziness, persistent postural-perceptual dizziness (PPPD), phobic postural vertigo (PPV), and chronic subjective dizziness (CSD), the effect of the invention lying in the possibility of treating functional dizziness that is independent of depressive and anxious states, a clinically optimal speed of onset of therapeutic action, ease of dose titration, a lack of a sedative effect, and a favorable safety profile.

IPC Classes  ?

• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 25/00 - Drugs for disorders of the nervous system

Goods & Services

Balms for medical purposes; bandages for dressings; dietetic substances adapted for medical use; mineral waters for medical purposes; mineral food supplements; cod liver oil; insecticides; capsules for medicines; cachets for pharmaceutical purposes; wart pencils; adhesive plasters; lotions for pharmaceutical purposes; liniments; gauze for dressings; medicinal oils; dental abrasives; dental impression materials; teeth filling material; dressings, medical; drugs for medical purposes; medicines for veterinary purposes; medicines for human purposes; medicines for dental purposes; medicinal drinks; dietetic beverages adapted for medical purposes; medicinal infusions; tinctures for medical purposes; decoctions for pharmaceutical purposes; medical plasters; pomades for medical purposes; bacterial preparations for medical and veterinary use; bacteriological preparations for medical and veterinary use; biological preparations for medical or veterinary purposes; veterinary preparations; air purifying preparations; sterilising preparations; preparations for destroying noxious animals; herbicides; larvae exterminating preparations; pharmaceutical preparations for skin care; contact lens cleaning preparations; pharmaceutical preparations; chemico-pharmaceutical preparations; chemical preparations for veterinary purposes; chemical preparations for medical purposes; chemical preparations for pharmaceutical purposes; dietetic foods adapted for medical purposes; sanitary towels; vaginal washes for medical purposes; disinfectants for contact lenses; solutions for contact lenses; insect repellents; tobacco-free cigarettes for medical purposes; syrups for pharmaceutical purposes; greases for veterinary purposes; greases for medical purposes; semen for artificial insemination; adjuvants for medical purposes; parasiticides; mouthwashes for medical purposes; detergents for medical purposes; steroids; serums; tampons for medical purposes; medicinal herbs; sanitary panties; fungicides; elixirs [pharmaceutical preparations]; poisons; sanitary tampons; wadding for medical purposes; mustard plasters; nutritional supplements; candy, medicated; first-aid boxes, filled; medicine cases, portable, filled; compresses; chemical conductors for electrocardiograph electrodes; albuminous foodstuffs for medical purposes; food for babies; chewing gum for medical purposes. Credit bureau services; debt collection agency services; real estate agency services; financial analysis; lease-purchase financing; savings bank services; accommodation bureau services [apartments]; rent collection; issuance of travelers' checks; issuance of credit cards; issuance of tokens of value; capital investment; insurance information; financial information; clearing, financial; insurance consultancy; financial consultancy; stock exchange quotations; business liquidation services, financial; brokerage; financial management; exchanging money; factoring; antique appraisal; jewelry appraisal; stamp appraisal; real estate appraisal; financial evaluation [insurance, banking, real estate]; surety services; charitable fund raising; financial sponsorship; insurance underwriting; real estate management; banking; financing services; fiscal valuation; safe deposit services; duty drawback services; financial customs brokerage services; rental of farms; processing of debit card payments; processing of credit card payments; numismatic appraisal; art appraisal; electronic funds transfer; real estate brokerage; insurance brokerage; loans [financing]; pawnbrokerage; check verification; real estate lease surrender services; mortgage lending; instalment loans; apartment house management; actuarial services; retirement payment services; trusteeship; mutual funds; deposits of valuables.

Goods & Services

Pharmaceutical preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use; food for babies; medical plasters; materials for dressings.

Abstract

The invention relates to the field of the chemical and pharmaceutical industry and medicine, and concerns methods for producing new formulations of neuroleptics. The present pharmaceutical composition containing alimemazine tartrate and excipients is characterised in that the following are selected as excipients: microcrystalline cellulose, hypromellose, colloidal silicon dioxide and magnesium stearate.

IPC Classes  ?

• A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
• A61K 47/38 - Cellulose; Derivatives thereof
• A61K 47/12 - Carboxylic acids; Salts or anhydrides thereof
• A61K 47/04 - Non-metals; Compounds thereof
• A61K 9/30 - Organic coatings
• A61K 9/22 - Sustained or differential release type
• A61P 25/18 - Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• A61P 25/00 - Drugs for disorders of the nervous system

Goods & Services

Pharmaceutical preparations; nutritional supplements; mineral nutritional supplements; albumin dietary supplements; chemico-pharmaceutical preparations; drugs for medical purposes; medicines for human purposes.

Abstract

The invention relates to the field of medicine and concerns an agent that stimulates tissue regeneration and the recovery of diminished tissue and organ function. A medicinal agent for the treatment and/or prophylaxis of a pathological condition selected from the group including metabolic syndrome, impaired glucose tolerance, hepatitis, particularly chronic hepatitis and toxic hepatitis, idiopathic pulmonary fibrosis (IPF), emphysema of the lungs, chronic obstructive pulmonary disease (COPD) and cachexia, particularly as a result of impaired glucose tolerance, pulmonary fibrosis, chronic obstructive pulmonary disease, cancer and other diseases, is proposed in the form of an agent based on Treamide. The latter is a bisamide derivative of dicarboxylic acid of formula (I) or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

• A61K 31/417 - Imidazole-alkylamines, e.g. histamine, phentolamine
• A61P 31/20 - Antivirals for DNA viruses
• A61P 3/08 - Drugs for disorders of the metabolism for glucose homeostasis
• A61P 19/04 - Drugs for skeletal disorders for non-specific disorders of the connective tissue
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 1/18 - Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
• A61K 31/4164 - 1,3-Diazoles
• A61P 15/08 - Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Goods & Services

Pharmaceuticals, medical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, dietary supplements for human beings and animals.

Goods & Services

Pharmaceutical preparations; chemico-pharmaceutical preparations.

Goods & Services

Pharmaceutical preparations; dietetic substances adapted for medical use; nutritional supplements for medical purposes; mineral nutritional supplements; dietary supplements; chemico-pharmaceutical preparations; chemical preparations for medical purposes; chemical preparations for pharmaceutical purposes; medicines for human purposes; pharmaceutical preparations and substances for the treatment of gastrointestinal diseases; elixirs [pharmaceutical preparations].

Abstract

The invention relates to the field of medicine and concerns an agent that stimulates tissue regeneration and the recovery of diminished tissue and organ function. A medicinal agent for the treatment and/or prophylaxis of a pathological condition selected from the group including metabolic syndrome, impaired glucose tolerance, hepatitis, particularly chronic hepatitis and toxic hepatitis, idiopathic pulmonary fibrosis (IPF), emphysema of the lungs, chronic obstructive pulmonary disease (COPD) and cachexia, particularly as a result of impaired glucose tolerance, pulmonary fibrosis, chronic obstructive pulmonary disease, cancer and other diseases, is proposed in the form of an agent based on Treamide. The latter is a bisamide derivative of dicarboxylic acid of formula (I) or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

• A61K 31/417 - Imidazole-alkylamines, e.g. histamine, phentolamine
• A61P 19/04 - Drugs for skeletal disorders for non-specific disorders of the connective tissue
• A61P 3/08 - Drugs for disorders of the metabolism for glucose homeostasis
• A61P 31/20 - Antivirals for DNA viruses
• A61P 1/18 - Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
• A61P 15/08 - Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

The invention relates to the chemical-pharmaceutical industry, and specifically to a pharmaceutical composition in tablet form, containing: 2.0-15.0 wt% memantine; 1.5-10.0 wt% melatonin; 65.0-80.0 wt% of a filler, selected from mannitol or a mixture of mannitol and copovidone; 4.0-15.0 wt% of a disintegrant selected from crospovidone; 1.0-2.0 wt% of a binder, selected from sorbitol; 1.0-2.5 wt% of a sweetener, selected from maltitol, sodium saccharinate or a mixture thereof; 0.5-1.0 wt% of a glidant, selected from colloidal silicon dioxide, stearic acid, magnesium stearate, talc or mixtures thereof; and 1.5-3.0 wt% of aromatizing agent; and also to a method for obtaining said pharmaceutical composition. The invention provides for broadening the range of pharmaceutical compositions containing a combination of memantine and melatonin, and also for increasing the storage stability and dissolution rate thereof.

IPC Classes  ?

• A61K 31/13 - Amines, e.g. amantadine
• A61K 9/20 - Pills, lozenges or tablets
• A61K 31/4045 - Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The invention relates to the chemical-pharmaceutical industry, and specifically to a pharmaceutical composition in tablet form, containing: 2.0-15.0 wt% memantine; 1.5-10.0 wt% melatonin; 65.0-80.0 wt% of a filler, selected from mannitol or a mixture of mannitol and copovidone; 4.0-15.0 wt% of a disintegrant selected from crospovidone; 1.0-2.0 wt% of a binder, selected from sorbitol; 1.0-2.5 wt% of a sweetener, selected from maltitol, sodium saccharinate or a mixture thereof; 0.5-1.0 wt% of a glidant, selected from colloidal silicon dioxide, stearic acid, magnesium stearate, talc or mixtures thereof; and 1.5-3.0 wt% of aromatizing agent; and also to a method for obtaining said pharmaceutical composition. The invention provides for broadening the range of pharmaceutical compositions containing a combination of memantine and melatonin, and also for increasing the storage stability and dissolution rate thereof.

IPC Classes  ?

• A61K 31/13 - Amines, e.g. amantadine
• A61K 31/4045 - Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
• A61K 9/20 - Pills, lozenges or tablets
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Goods & Services

Breath freshening sprays; balms other than for medical purposes; gum balms, not for medical purposes; gelling agents for oral care, not for medical purposes; creams for leather; cosmetic creams; lotions for cosmetic purposes; after-shave lotions; toothpastes; dentifrices; prophylactic toothpastes, not for medical purposes; preparations for cleaning teeth; mouth washes, not for medical purposes; dental rinses for gums; mouth rinses, not for medical purposes; preparations for the care of mouth, not for medical purposes; preparations for the care of teeth, not for medical purposes; preparations for the care of gums, not for medical purposes; elixir for gums, not for medical purposes; elixir for oral care, not for medical purposes; cosmetic preparations for skin care; cosmetics. Pharmaceuticals and veterinary preparations; sanitary preparations for medical purposes, including balms for medical purposes; lotions for veterinary purposes; dog lotions; lotions for pharmaceutical purposes; liniments; ointments for pharmaceutical purposes; pharmaceutical preparations for skin care; adjuvants for medical purposes; oral care preparations for medical purposes, including dentifrices, mouthwashes; medicated dentifrices; treatment and prophylactic toothpastes (medicated); elixirs [pharmaceutical preparations] including elixir for gums; elixir for oral care. Advertising; business management; business administration; office functions; demonstration of goods including the goods in classes 03, 05; market studies; organization of exhibitions for commercial or advertising purposes; organization of trade fairs for commercial or advertising purposes; presentation of goods on communication media, for retail purposes; sales promotion for others, including relating to the goods in class 03, 05; distribution of samples; dissemination of advertising matter; procurement services for others [purchasing goods and services for other businesses], including relating to goods in class 03, 05.

Abstract

The invention relates to the field of medicine and the chemical and pharmaceutical industry, and comprises a pharmaceutical composition in the form of a biologically-active solution characterized by including glibenclamide as an active principle and including, as auxiliary substances, hydroxyethyl starch and water for injection. The invention also relates to methods for producing pharmaceutical compositions of glibenclamide in the form of a solution for injection. The compositions are effective, safe and may be applied for extended periods.

IPC Classes  ?

• A61K 9/08 - Solutions
• A61K 31/64 - Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The group of inventions relates to the pharmaceutical chemical industry and concerns neuroleptic class drugs. The present pharmaceutical formulations in tablet form with sustained release contain clozapine as the active ingredient and, as excipients, microcrystalline cellulose, hydroxypropyl methylcellulose, lactose, copovidone, colloidal silicon dioxide, and stearates. The methods for producing the tablet forms are based on a roller compaction method. The group of inventions provides for the manufacture of a stable pharmaceutical clozapine formulation in tablet form with sustained release, with stable handling characteristics and reproducible release kinetics for the active ingredient.

IPC Classes  ?

• A61K 9/22 - Sustained or differential release type
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61K 47/04 - Non-metals; Compounds thereof
• A61K 47/12 - Carboxylic acids; Salts or anhydrides thereof
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 47/38 - Cellulose; Derivatives thereof

Abstract

The invention relates to the field of medicine and to the chemical-pharmaceutical industry, and pertains to agents for use in the case of sleep disorders. A pharmaceutical composition for initiating and maintaining the sleep process and for preventing, in animals and humans, conditions associated with various types of sleep disorders, said composition being characterized in that it includes effective quantities of doxylamine succinate and slow-release melatonin. The technical result consists in synergistic therapeutic effects, biological succession, and reduced side effects.

IPC Classes  ?

• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/4045 - Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
• A61K 31/4402 - Non-condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
• A61P 25/20 - Hypnotics; Sedatives

Abstract

The invention relates to the field of medicine and the pharmaceutical chemical industry. Proposed is a pharmaceutical composition for treating infectious inflammatory diseases, in the form of a solution for topical application, containing, as active ingredient, a combination of gramicidin S dihydrochloride, oxybuprocaine hydrochloride and cetylpyridinium chloride and, as excipients, ethanol 96%, sucralose, glycerol, citric acid monohydrate, sodium citrate, polysorbate, methylparaben, propylparaben, natural mint flavouring, and purified water. Also proposed is a method for producing and using same.

IPC Classes  ?

• A61K 9/12 - Aerosols; Foams
• A61K 38/12 - Cyclic peptides
• A61K 31/44 - Non-condensed pyridines; Hydrogenated derivatives thereof
• A61K 31/245 - Amino benzoic acid types, e.g. procaine, novocaine
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

The invention relates to the field of medicine and the pharmaceutical chemical industry. Proposed is a pharmaceutical composition for treating infectious inflammatory diseases, in the form of a solution for topical application, characterised in that it contains, as active ingredient, a combination of gramicidin S dihydrochloride and cetylpyridinium chloride and, as excipients, ethanol 96%, sucralose, glycerol, citric acid monohydrate, sodium citrate, polysorbate, methylparaben, propylparaben, natural mint flavouring and purified water. Also proposed is a method for producing and using same.

IPC Classes  ?

• A61K 38/12 - Cyclic peptides
• A61K 31/44 - Non-condensed pyridines; Hydrogenated derivatives thereof
• A61K 9/12 - Aerosols; Foams
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

The present invention relates to the chemical and pharmaceutical industries and medicine, and pertains to means for treating demyelinating diseases. A pharmaceutical composition in solid dosage form, exhibiting a therapeutic effect with regard to demyelinating diseases and particularly multiple sclerosis, containing biotin as an active ingredient and certain ratios of target additives.

IPC Classes  ?

• A61K 31/4188 - 1,3-Diazoles condensed with heterocyclic ring systems, e.g. biotin, sorbinil
• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61P 25/00 - Drugs for disorders of the nervous system

Goods & Services

Drugs for medical purposes; medicines for human purposes; pharmaceutical preparations; chemico-pharmaceutical preparations.

Goods & Services

Drugs for medical purposes; medicines for human purposes; pharmaceutical preparations; chemico-pharmaceutical preparations.

Abstract

The invention relates to the field of medicine and concerns an agent that stimulates tissue regeneration and the recovery of diminished tissue and organ function. A medicinal agent for the treatment and/or prophylaxis of a pathological condition selected from the group including metabolic syndrome, impaired glucose tolerance, hepatitis, particularly chronic hepatitis and toxic hepatitis, idiopathic pulmonary fibrosis (IPF), emphysema of the lungs, chronic obstructive pulmonary disease (COPD) and cachexia, particularly as a result of impaired glucose tolerance, pulmonary fibrosis, chronic obstructive pulmonary disease, cancer and other diseases, is proposed in the form of an agent based on Treamide. The latter is a bisamide derivative of dicarboxylic acid of formula (I) or a pharmaceutically acceptable salt thereof. (I)

IPC Classes  ?

• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/4164 - 1,3-Diazoles
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 1/18 - Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 13/08 - Drugs for disorders of the urinary system of the prostate
• A61P 15/08 - Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Goods & Services

Medicines for human purposes with neuroleptic qualities and a sedative, antipsychotic, antiemetic effect.

Goods & Services

Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use; food for babies; plasters, materials for dressings; disinfectants.

Goods & Services

Drugs for medical purposes; medicines for human purposes; pharmaceutical preparations; chemico-pharmaceutical preparations.

Goods & Services

Drugs for medical purposes; medicines for human purposes; pharmaceutical preparations; chemico-pharmaceutical preparations.

Goods & Services

Dietetic substances adapted for medical use; diastase for medical purposes; mineral food supplements; nutritional supplements; albumin dietary supplements; enzyme dietary supplements; drugs for medical purposes; medicines for human purposes; pepsins for pharmaceutical purposes; albuminous preparations for medical purposes; pharmaceutical preparations; enzyme preparations for medical purposes; chemico-pharmaceutical preparations; enzymes for medical purposes; ferments for pharmaceutical purposes.