Omniab Operations, Inc.

United States of America

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2024 November 1
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IPC Class
C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies 7
C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells 7
A01K 67/027 - New or modified breeds of vertebrates 6
C12N 9/22 - Ribonucleases 3
A01K 67/00 - Rearing or breeding animals, not otherwise provided forNew or modified breeds of animals 2
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Status
Pending 3
Registered / In Force 8
Found results for  patents

1.

HUMAN ANTIBODIES FROM TRANSGENIC RODENTS WITH MULTIPLE HEAVY CHAIN IMMUNOGLOBULIN LOCI

      
Application Number 18752374
Status Pending
Filing Date 2024-06-24
First Publication Date 2024-11-14
Owner OMNIAB OPERATIONS, INC. (USA)
Inventor
  • Buelow, Roland
  • Bruggemann, Marianne
  • Ma, Biao
  • Osborn, Michael J.

Abstract

A polyclonal antiserum composition including a repertoire of antigen-specific artificial immunoglobulins, each antigen-specific artificial immunoglobulin including: one or more human heavy chain VH segment(s); one or more D segment(s); one or more J segment(s); and one or more constant region segment(s).

IPC Classes  ?

  • A01K 67/0278 - Knock-in vertebrates, e.g. humanised vertebrates
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

2.

COMPOSITIONS AND METHODS FOR INHIBITING ENDOGENOUS IMMUNOGLOBULIN GENES AND PRODUCING TRANSGENIC HUMAN IDIOTYPE ANTIBODIES

      
Application Number 17131164
Status Pending
Filing Date 2020-12-22
First Publication Date 2021-08-19
Owner OMNIAB OPERATIONS, INC. (USA)
Inventor Buelow, Roland

Abstract

The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The invention further relates to methods for producing transgenic antibodies in such animals, and transgenic antibodies so produced.

IPC Classes  ?

  • C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
  • A01K 67/027 - New or modified breeds of vertebrates
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • C12N 9/22 - Ribonucleases
  • C12N 5/075 - OocytesOogonia

3.

Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci

      
Application Number 16478466
Grant Number 12016313
Status In Force
Filing Date 2018-01-19
First Publication Date 2020-05-28
Grant Date 2024-06-25
Owner OMNIAB OPERATIONS, INC. (USA)
Inventor
  • Buelow, Roland
  • Bruggemann, Marianne
  • Ma, Biao
  • Osborn, Michael J.

Abstract

The invention relates to transgenic animals useful for optimal production of functional immunoglobulins with human idiotypes.

IPC Classes  ?

  • A01K 67/0278 - Knock-in vertebrates, e.g. humanised vertebrates
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

4.

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

      
Application Number 15332583
Grant Number 10385132
Status In Force
Filing Date 2016-10-24
First Publication Date 2017-06-22
Grant Date 2019-08-20
Owner OMNIAB OPERATIONS, INC. (USA)
Inventor
  • Bruggemann, Marianne
  • Buelow, Roland
  • Osborn, Michael J.
  • Ma, Biao

Abstract

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

IPC Classes  ?

  • A01K 67/027 - New or modified breeds of vertebrates
  • C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
  • C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

5.

Humanized monoclonal antibodies from a transgenic rat

      
Application Number 15206063
Grant Number 10072069
Status In Force
Filing Date 2016-07-08
First Publication Date 2016-10-27
Grant Date 2018-09-11
Owner OMNIAB OPERATIONS, INC. (USA)
Inventor Buelow, Roland

Abstract

The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The invention further relates to methods for producing transgenic antibodies in such animals, and transgenic antibodies so produced.

IPC Classes  ?

  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
  • A01K 67/027 - New or modified breeds of vertebrates
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • C12N 9/22 - Ribonucleases
  • C12N 5/075 - OocytesOogonia

6.

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

      
Application Number 14517755
Grant Number 09475859
Status In Force
Filing Date 2014-10-17
First Publication Date 2015-04-23
Grant Date 2016-10-25
Owner OMNIAB OPERATIONS, INC. (USA)
Inventor
  • Bruggemann, Marianne
  • Buelow, Roland
  • Osborn, Michael J.
  • Ma, Biao

Abstract

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

IPC Classes  ?

  • A01K 67/027 - New or modified breeds of vertebrates
  • C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies

7.

Rat having a disrupted immunoglobulin gene

      
Application Number 13192407
Grant Number 09388233
Status In Force
Filing Date 2011-07-27
First Publication Date 2012-04-12
Grant Date 2016-07-12
Owner OMNIAB OPERATIONS, INC. (USA)
Inventor Buelow, Roland

Abstract

The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The invention further relates to methods for producing transgenic antibodies in such animals, and transgenic antibodies so produced.

IPC Classes  ?

  • A01K 67/00 - Rearing or breeding animals, not otherwise provided forNew or modified breeds of animals
  • C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
  • A01K 67/027 - New or modified breeds of vertebrates
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • C12N 9/22 - Ribonucleases

8.

Methods for producing transgenic rodents having recombinant immunoglobulin loci

      
Application Number 12701464
Grant Number 08907157
Status In Force
Filing Date 2010-02-05
First Publication Date 2010-08-19
Grant Date 2014-12-09
Owner OMNIAB OPERATIONS, INC. (USA)
Inventor Buelow, Roland

Abstract

The invention provides methods for the production of transgenic animals comprising a recombinant Ig locus, as well as transgenic antibodies derived therefrom. The methods involve meganuclease cleavage-stimulated homologous recombination in mammalian embryos.

IPC Classes  ?

  • A01K 67/00 - Rearing or breeding animals, not otherwise provided forNew or modified breeds of animals
  • C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor

9.

Germ cells having inactivated endogenous immunoglobulin genes, and transgenic animals derived therefrom

      
Application Number 12130818
Grant Number 08703485
Status In Force
Filing Date 2008-05-30
First Publication Date 2009-04-16
Grant Date 2014-04-22
Owner OMNIAB OPERATIONS, INC. (USA)
Inventor Buelow, Roland

Abstract

The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The invention further relates to methods for producing transgenic antibodies in such animals, and transgenic antibodies so produced.

IPC Classes  ?

  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
  • A01K 67/027 - New or modified breeds of vertebrates

10.

COMPOSITIONS AND METHODS FOR INHIBITING ENDOGENOUS IMMUNOGLOBULIN GENES AND PRODUCING TRANSGENIC HUMAN IDIOTYPE ANTIBODIES

      
Document Number 02688834
Status In Force
Filing Date 2008-05-30
Open to Public Date 2008-12-11
Grant Date 2020-01-07
Owner OMNIAB OPERATIONS, INC. (USA)
Inventor Buelow, Ronald

Abstract

The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The invention further relates to methods for producing transgenic antibodies in such animals, and transgenic antibodies so produced.

IPC Classes  ?

  • C12N 15/13 - Immunoglobulins
  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
  • C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
  • C12N 15/09 - Recombinant DNA-technology
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • C12P 21/08 - Monoclonal antibodies

11.

COMPOSITIONS AND METHODS FOR INHIBITING ENDOGENOUS IMMUNOGLOBULIN GENES AND PRODUCING TRANSGENIC HUMAN IDIOTYPE ANTIBODIES

      
Document Number 03054224
Status Pending
Filing Date 2008-05-30
Open to Public Date 2008-12-11
Owner OMNIAB OPERATIONS, INC. (USA)
Inventor Buelow, Ronald

Abstract

The invention relates to transgenic animals lacking endogenous lg and capable of producing transgenic antibodies, as well as methods of making the same. The invention further relates to methods for producing transgenic antibodies in such animals, and transgenic antibodies so produced.

IPC Classes  ?

  • C12P 21/08 - Monoclonal antibodies
  • C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
  • C07K 16/46 - Hybrid immunoglobulins
  • C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
  • C12N 5/16 - Animal cells
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells