The purpose of the present invention is to identify a novel substance/factor involved in anti-inflammatory activities of beet, and to provide the substance/factor. This will enable development of health care products such as pharmaceutical products, foods, and cosmetics for suppressing chronic inflammation. Provided is a lipopolysaccharide characterized by being obtained from a bacterium that has been deposited under accession number NITE BP-03839, NITE BP-03840, NITE BP-03841, NITE BP-03842, or NITE BP-03843. Also provided is a pharmaceutical product, a pharmaceutical product for veterinary use, a quasi-pharmaceutical product, a cosmetic, a food, a functional food, a feed, a fertilizer, or a bath additive in which the lipopolysaccharide is blended.
C12P 1/04 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes by using bacteria
A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
An object of the present invention is to provide a lipopolysaccharide production method that contributes to labor hygiene and environmental conservation and is suited for large-scale production and a lipopolysaccharide produced thereby. The present invention relates to a lipopolysaccharide production method, etc., with which a lipopolysaccharide is extracted and purified from gram-negative bacterium and is a lipopolysaccharide production method that includes a first step of performing extraction from the gram-negative bacterium using hot water to obtain an extract liquid that contains the lipopolysaccharide and a second step of purifying the extract liquid or a solution containing the LPS in the extract liquid by using reverse-phase liquid chromatography to obtain the lipopolysaccharide and in that a reverse-phase column used in the reverse-phase liquid chromatography has a packing material constituted of a material having a functional group of 1 to 8 carbons.
The purpose of the present invention is to provide: a lipopolysaccharide production method that is suitable for mass production and that contributes to environmental conservation and occupational health; and a lipopolysaccharide produced by the method. This lipopolysaccharide production method is for extracting and purifying a lipopolysaccharide from gram-negative bacteria, and comprises: a first step for obtaining an extraction solution containing the lipopolysaccharide by performing extraction on the gram-negative bacteria using hot water; and a second step for obtaining the lipopolysaccharide by refining, using reverse-phase liquid chromatography, the extraction solution or a solution containing LPS in the extraction solution, wherein a reversed-phase column used in the reverse-phase liquid chromatography includes a filler formed of a material that has a functional group having 1-8 carbon atoms.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
limulus-positive glycolipid can be used for various applications such as pharmaceuticals, pharmaceuticals for animals, quasi drugs, cosmetics, foods, functional foods, feedstuff and bath agents.
The disease resistance capability of plants such as vegetables, grasses and flowers and the rearing rate of the plants can be improved by rearing the plants in the co-presence of a glycolipid derived from Pantoea agglomerans or a preparation containing the glycolipid. Thus, disclosed is a method for enhancing the resistance of vegetables, grasses or flowers against diseases and rearing high-quality crops; a novel plant-rearing agent and a novel plant disease resistance inducer which can be used in the method. The method and others enable the cultivation of crops with using agrochemicals in less amounts as possible or the improvement in productivities of crops. Further, even when the amounts of agrichemicals used are reduced, the success rates in the cultivation of crops can be increased and the immunological capacities of plants can also be improved even when useful soil bacteria occur in less amounts. Therefore, new types of crop businesses such as contract cultivation by means of organic cultivation, chemical-free cultivation or hydroponic cultivation can be spurred.
Xanthan gum, which is derived from a Xanthomonas microorganism, has been commercially supplied and eaten for many years. It is now found that xanthan gum contains a limulus-positive glycolipid. The limulus-positive glycolipid is purified from xanthan gum, and it is found that the limulus-positive glycolipid has an immunostimulating effect. Disclosed is a method for production of a limulus-positive glycolipid containing an immunostimulating substance safely, at a low cost, and in a high concentration. The method is characterized by extracting a limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid blend containing the limulus-positive glycolipid can be used in various applications including pharmaceuticals, veterinary pharmaceuticals, quasi-drugs, cosmetics, foods, functional foods, feeding stuffs and bathwater additives.
A61K 8/99 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
