Abstract

A method for continuous synthesis of p-toluenesulfonyl chloride. Toluene, sulfur trioxide, chlorosulfonic acid, organic bases and a solvent are mixed in a first static mixer and pumped into a first microreactor for reaction. A primary reaction mixture discharged from an outlet of the first microreactor flows into a second static mixer, and is mixed with sulfur trioxide, chlorosulfonic acid, low-carbon chain fatty acid and a solvent that are pumped into the second static mixer respectively. The obtained mixed material is pumped into a second microreactor for reaction. A secondary reaction mixture discharged from the second microreactor is cooled, crystallized and separated to obtain p-toluenesulfonyl chloride as a product. According to the method, the production efficiency can be improved. Due to the addition of a sulfone inhibitor, the problem of easy generation of a large amount of sulfone substances and polysulfonates by sulfur trioxide is effectively solved, and hydrogen chloride gas is prevented from being generated.

IPC Classes  ?

• C07C 303/06 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups by reaction with sulfuric acid or sulfur trioxide
• C07C 303/08 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups by reaction with halogenosulfonic acids
• C07C 309/86 - Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus