Disclosed herein are topical nitric oxide (NO) formulations containing a surfactant and methods that deliver NO to treat skin wounds, burns, infections, site of inflammations, or other skin conditions requiring treatment, as well as to eradicate and degrade biofilms on the skin surface. The NO formulations can be modified to prolong the time of NO exposure by modulating the surfactant concentration.
Disclosed herein are topical nitric oxide (NO) formulations containing a surfactant and methods that deliver NO to treat skin wounds, burns, infections, site of inflammations, or other skin conditions requiring treatment, as well as to eradicate and degrade biofilms on the skin surface. The NO formulations can be modified to prolong the time of NO exposure by modulating the surfactant concentration.
A nitric oxide (NO) formulation delivery device comprising a first cartridge containing a first liquid solution and a first foaming device configured to transform the first liquid solution into a first foam solution, a second cartridge containing a second liquid solution and a second foaming device configured to transform the second liquid solution into a second foam solution, a plenum in fluid communication with the first cartridge and the second cartridge, the plenum being configured to combine the first foam solution and the second foam solution to create a combined turbulent foam solution, and a nozzle in fluid communication with the confluence portion and configured to uniformly discharge the combined turbulent foam solution.
A nitric oxide (NO) formulation delivery device comprising a first cartridge containing a first liquid solution and a first foaming device configured to transform the first liquid solution into a first foam solution, a second cartridge containing a second liquid solution and a second foaming device configured to transform the second liquid solution into a second foam solution, a plenum in fluid communication with the first cartridge and the second cartridge, the plenum being configured to combine the first foam solution and the second foam solution to create a combined turbulent foam solution, and a nozzle in fluid communication with the confluence portion and configured to uniformly discharge the combined turbulent foam solution.
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 36/61 - Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
A61K 36/886 - Aloeaceae (Aloe family), e.g. aloe vera
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Medicated cosmetic preparations in the form of topical foams for treatment of a variety of skin conditions, none of the foregoing are for the prevention or treatment of acne
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
medicated cosmetic preparations in the form of topical foams for treatment of a variety of skin conditions; antiseptic preparations in the form of topical foams; none of the foregoing are for the prevention or treatment of acne
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
medicated cosmetic preparations in the form of topical foams for treatment of a variety of skin conditions; antiseptic preparations in the form of topical foams; none of the foregoing are for the prevention or treatment of acne
10.
NITRIC OXIDE TOPICAL APPLICATION APPARATUS AND METHODS
A topical application of nitric oxide may be provided by two separate containers, each containing an active component media to produce nitric oxide when combined. For example, a nitrite component media may be contained in one dispenser and an acidified component media may be contained in another dispenser. Each dispenser may dispense the respective component media as a foam. The resultant foams are combined to initiate the production of nitric oxide and the mixture of foams is applied topically to treat various skin disorders or wounds.
This invention is directed to a topical nitric oxide formulation that can be used to treat skin conditions. The invention is also directed to a method for using the topical nitric oxide formulation to treat skin conditions, as well as to a device to administer the topical pharmaceutical formulation to an area of the skin that requires treatment.
This invention is directed to a topical nitric oxide formulation that can be used to treat skin conditions. The invention is also directed to a method for using the topical nitric oxide formulation to treat skin conditions, as well as to a device to administer the topical pharmaceutical formulation to an area of the skin that requires treatment.
An adhesive bandage that is capable of delivering nitric oxide gas to skin is generally disclosed. The bandage may be used for topical skin therapy of a patient, such as, for example, to promote healing of a wound or condition, or to provide exogenous nitric oxide supplementation.
An adhesive bandage that is capable of delivering nitric oxide gas to skin is generally disclosed. The bandage may be used for topical skin therapy of a patient, such as, for example, to promote healing of a wound or condition, or to provide exogenous nitric oxide supplementation.
A61L 15/18 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
A system for producing a gas-filled medium comprises a first pressurized vessel containing a gas, a second vessel containing a surfactant solution, a dose chamber in fluid communication with the first pressurized vessel, a mixing chamber in fluid communication with the dose chamber and the second vessel, the mixing chamber being configured to mix the gas flowing out of the dose chamber and the surfactant solution flowing out of the second vessel to produce a gas-filled solution, and a foaming nozzle comprising mesh screens configured to convert the gas-filled solution into a gas-filled foam medium, the foaming nozzle configured to discharge the gas-filled foam medium.
A system for producing a gas-filled medium comprises a first pressurized vessel containing a gas, a second vessel containing a surfactant solution, a dose chamber in fluid communication with the first pressurized vessel, a mixing chamber in fluid communication with the dose chamber and the second vessel, the mixing chamber being configured to mix the gas flowing out of the dose chamber and the surfactant solution flowing out of the second vessel to produce a gas-filled solution, and a foaming nozzle comprising mesh screens configured to convert the gas-filled solution into a gas-filled foam medium, the foaming nozzle configured to discharge the gas-filled foam medium.
Systems, products, compounds and methods can be applied and/or used by a person to facilitate and promote the production of nitric oxide to be used by a person for health benefits. The systems, products, and devices include a nitric oxide nasal delivery system. The system can comprise one or more containers for compounds that when mixed are adapted to produce nitric oxide gas, at least one container with a nitrite powder and an acidic powder. The nitric oxide gas may then be delivered to a user via one or more of the nasal cavities and/or mouth.
Systems, products, compounds, and methods can be applied and/or used by a person to facilitate and promote the production of nitric oxide to be used by a person for health benefits. The systems, products, and devices include a nitric oxide bath system. The systems and methods can comprise one or more compounds that when mixed are adapted to produce nitric oxide gas, with at least one nitrite compound and at least one acid compound. The nitric oxide gas may then be delivered to a user transdermally via one or more bath applications.
Systems, products, compounds and methods can be applied and/or used by a person to facilitate and promote the production of nitric oxide to be used by a person for health benefits. The systems, products, and devices include a nitric oxide nasal delivery system. The system can comprise one or more containers for compounds that when mixed are adapted to produce nitric oxide gas, at least one container with a nitrite compound and at least one container with an acid compound. Containers can be ruptured so that the compounds may be mixed and produce nitric oxide gas. The nitric oxide gas may then be delivered to a user via one or more of the nasal cavities and/or mouth.
Systems, products, compounds, and methods can be applied and/or used by a person to facilitate and promote the production of nitric oxide to be used by a person for health benefits. The systems, products, and devices include a nitric oxide bath system. The systems and methods can comprise one or more compounds that when mixed are adapted to produce nitric oxide gas, with at least one nitrite compound and at least one acid compound. The nitric oxide gas may then be delivered to a user transdermally via one or more bath applications.
Systems, products, compounds, and methods can be applied and/or used by a person to facilitate and promote the production of nitric oxide to be used by a person for health benefits. The systems, products, and devices include a nitric oxide bath system. The systems and methods can comprise one or more compounds that when mixed are adapted to produce nitric oxide gas, with at least one nitrite compound and at least one acid compound. The nitric oxide gas may then be delivered to a user transdermally via one or more bath applications.
A topical application of nitric oxide may be provided by two separate containers, each containing an active component media to produce nitric oxide when combined. For example, a nitrite component media may be contained in one dispenser and an acidified component media may be contained in another dispenser. Each dispenser may dispense the respective component media as a foam or a solution. They can be combined to initiate the production of nitric oxide and the mixture of resultant foam is applied topically to treat various skin disorders or wounds.
A topical application of nitric oxide may be provided by two separate containers, each containing an active component media to produce nitric oxide when combined. For example, a nitrite component media may be contained in one dispenser and an acidified component media may be contained in another dispenser. Each dispenser may dispense the respective component media as a foam. The resultant foams are combined to initiate the production of nitric oxide and the mixture of foams is applied topically to treat various skin disorders or wounds.
A topical application of nitric oxide may be provided by two separate containers, each containing an active component media to produce nitric oxide when combined. For example, a nitrite component media may be contained in one dispenser and an acidified component media may be contained in another dispenser. Each dispenser may dispense the respective component media as a foam. The resultant foams are combined to initiate the production of nitric oxide and the mixture of foams is applied topically to treat various skin disorders or wounds.
