Abstract

The present disclosure relates to trapping and manipulating of neutral atoms in optical trapping potentials. In one aspect, an apparatus comprises a trapping laser system and optics for generating an optical trapping lattice at a trapping volume inside a vacuum chamber, wherein the optics for generating the optical trapping lattice are configured to generate, based on the output of the trapping laser system, a single elliptical trapping laser beam that is retroreflected and focused, using a bow-tie configuration, to the trapping volume to generate the optical trapping lattice.

IPC Classes  ?

• G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating

Abstract

The present disclosure relates to trapping and manipulating neutral atoms for quantum computing, quantum simulation and metrology. In one aspect a method comprises loading a plurality of neutral atoms into a loading trap array arranged adjacent to or at least partially collocated with a storage trap array, selectively removing neutral atoms in a first electronic state |1> from the storage trap array, determining a trap occupancy of neutral atoms in the storage trap array in a second electronic state |2>, and of neutral atoms in the loading trap array, and moving, based on the determined trap occupancy of the neutral atoms in the storage trap array and in the loading trap array, neutral atoms from the loading trap array to one or more non-occupied trapping sites of the storage trap array. The method may further comprise shelving the neutral atoms in a shelving state.

IPC Classes  ?

• G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating

Abstract

The present invention relates to a catalytically active material, the preparation thereof, and the use of the catalytically active material, e.g. in the catalytic oxidation of CO to CO2 or in the catalytic hydrogenation of alkyne. The catalytically active material comprises a support5 comprising a metal oxide, and atomically dispersed noble metal on the surface of the support, wherein the metal oxide is selected from TiO2, CeO2, ZnO, SnO2, Ga2O3, In2O3, ZrO2, and Fe2O3, the noble metal is selected from Pt, Pd, Rh, and Au, and the catalytically active material is obtainable by a method comprising a step of non-thermal plasma treatment in the presence of O2.

IPC Classes  ?

• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• B01J 23/63 - Platinum group metals with rare earths or actinides
• B01J 35/45 - Nanoparticles
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/03 - PrecipitationCo-precipitation
• B01J 37/08 - Heat treatment
• C01B 32/50 - Carbon dioxide
• C07C 5/08 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation of carbon-to-carbon triple bonds

Abstract

3113, and further selecting out of these compounds the ones which contain at least a heavy metal for high spin polarization, and sort these selected compounds with increasing spin-orbit-coupling (SOC), which results in a number of compounds which are sorted with increasing catalytic activity.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/089 - Alloys
• H01M 4/90 - Selection of catalytic material
• H01M 4/92 - Metals of platinum group

Abstract

The invention is related to a method of using a thermal laser evaporation (TLE) system (100), the system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source (30) comprising a source material (32), and a laser source (50) for providing laser radiation (52) at a surface (34) of the source (30) and thereby evaporating the source material (32). Further, the invention is related to a thermal laser evaporation system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source comprising a source material (32), and coupling means (12) provided by the reaction chamber (10) for coupling laser radiation (52) into the reaction chamber (10) for impinging on a surface (34) of the source (30) and thereby evaporating the source material (32).

IPC Classes  ?

• C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
• B23K 26/06 - Shaping the laser beam, e.g. by masks or multi-focusing
• B23K 26/073 - Shaping the laser spot
• B23K 26/12 - Working by laser beam, e.g. welding, cutting or boring in a special environment or atmosphere, e.g. in an enclosure
• B23K 26/362 - Laser etching

Abstract

The invention is related to a method of using a thermal laser evaporation (TLE) system (100), the system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source (30) comprising a source material (32), and a laser source (50) for providing laser radiation (52) at a surface (34) of the source (30) and thereby sublimating the source material (32). Further, the invention is related to a thermal laser evaporation system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source comprising a source material (32), and coupling means (12) provided by the reaction chamber (10) for coupling laser radiation (52) into the reaction chamber (10) for impinging on a surface (34) of the source (30) and thereby sublimating the source material (32).

IPC Classes  ?

• C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
• B23K 26/06 - Shaping the laser beam, e.g. by masks or multi-focusing
• B23K 26/064 - Shaping the laser beam, e.g. by masks or multi-focusing by means of optical elements, e.g. lenses, mirrors or prisms
• B23K 26/067 - Dividing the beam into multiple beams, e.g. multi-focusing
• B23K 26/073 - Shaping the laser spot
• B23K 26/08 - Devices involving relative movement between laser beam and workpiece
• B23K 26/12 - Working by laser beam, e.g. welding, cutting or boring in a special environment or atmosphere, e.g. in an enclosure
• B23K 26/362 - Laser etching

Abstract

The present invention relates to a method for the generation of outer radial glial (oRG) cells of the outer sub-ventricular (oSVZ)-like region in cerebral organoids comprising (a) culturing primate stem cells in a primate stem cell medium until about day 6, thereby inducing the formation of embryonic bodies; (b) culturing the embryonic bodies as obtained in step (a) in a neural induction medium until about day 11, thereby inducing the formation of organoids; wherein an inhibitor of TGF-β, an inhibitor of BMP and an inhibitor of WNT is present from about day 2 until about day 11; (c) embedding the organoids as obtained after steps (a) and (b) and if they display a size of at least 300 μm into a hydrogel that mimics the extracellular matrix (ECM), preferably Matrigel and culturing the organoids in a cerebral differentiation medium at least until about day 40, preferably at least until about day 60 and most preferably at least until about day 80, thereby obtaining cerebral organoids with oRG cells in oSVZ-like regions, wherein the organoids in step (c) are subjected to agitation from about day 15 onward, preferably by using an orbital shaker or a spinning bioreactor; and (d) optionally isolating one or more oRG cells from the oSVZ-like region.

IPC Classes  ?

• C12N 5/079 - Neural cells
• C12N 5/0793 - Neurons

Abstract

A method of scattering-type scanning near-field optical microscopy (s-SNOM) comprises placing an s-SNOM tip 11 at a near-field distance from a sample 1 and subjecting the s-SNOM tip 11 to a mechanical oscillation, which provides a primary modulation, illuminating the oscillating s-SNOM tip 11 with a sequence of illumination light pulses, wherein each of the illumination light pulses hits the s-SNOM tip 11 at a specific s-SNOM tip modulation phase φi of the mechanical oscillation, collecting scattering light pulse amplitudes Si, each being created by scattering one of the illumination light pulses at the s-SNOM tip 11, using a scattering light detector device 30, collecting the s-SNOM tip modulation phase i associated to each of the collected scattering light pulse amplitudes Si, using a mechanical oscillation detector device 40, and calculating an s-SNOM near-field signal by demodulating a scattering light function S(φi) of the scattering light pulse amplitudes Si in dependency on the s-SNOM tip modulation phases φi, wherein each of the s-SNOM tip modulation phases pi is obtained by splitting an output signal of the mechanical oscillation detector device 40 into a first output signal portion X and a second output signal portion Y being phaseshifted relative to the first output signal portion X and calculating the s-SNOM tip modulation phase φi of the primary modulation from the first and second output signal portions X, Y. Furthermore, a scanning near-field optical microscopy apparatus 100 is described.

IPC Classes  ?

• G01Q 60/18 - SNOM [Scanning Near-Field Optical Microscopy] or apparatus therefor, e.g. SNOM probes

Abstract

The present invention relates to a temperature control system (10) for adjusting a temperature (60) of a vacuum chamber (102), the temperature control system (10) comprising conduits (20) which can be thermally coupled to a chamber wall (110) of the vacuum chamber (102), a fluid pump (50), temperature adjusting means (30) comprising a heating means (32) or both a heating means (32) and a cooling means (34), and tubing (52) for fluidly connecting said conduits (20), fluid pump (50), and temperature adjusting means (30), respectively. Further, the present invention relates to a vacuum system (100) with a vacuum chamber (102), the vacuum chamber (102) comprising a chamber wall (110) enclosing a vacuum volume (106), a vacuum pump system (104) connected to the vacuum chamber (102) for evacuating the vacuum volume (106), and a temperature control system (10) for adjusting a temperature (60) of a vacuum chamber (102). In addition, the present invention relates to a method of adjusting the temperature (60) of a vacuum chamber (102) of said vacuum system (100).

IPC Classes  ?

• C23C 14/54 - Controlling or regulating the coating process
• C23C 14/28 - Vacuum evaporation by wave energy or particle radiation

Abstract

NicotianaNicotiana tabacum Nicotiana sylvestris Nicotiana sylvestris.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The present invention relates to a compound of general formula (I) The present invention relates to a compound of general formula (I) The present invention relates to a compound of general formula (I) or an enantiomer, diastereomer, stereoisomer, which mediates resistance against leaf- and planthopper pests. The present invention further relates to a method of producing the compound, an enzymatic production method the compound using at least a BBL2 polypeptide, as well as a PPO, AT1, ODC, HPL, PAL, C4H, 4CL, HCT and/or C3H activity. Further envisaged are genetically modified organisms producing the compound, expression cassettes for heterologous expression of the activities, the use of corresponding polypeptides and polynucleotides for the production of the compound, a composition including the compound, as well as uses of the compound for plant protection.

IPC Classes  ?

• C07C 235/78 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
• A01N 37/42 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing within the same carbon skeleton a carboxylic group or a thio-analogue, or a derivative thereof, and a carbon atom having only two bonds to hetero atoms with at the most one bond to halogen, e.g. keto-carboxylic acids
• A01P 15/00 - Biocides for specific purposes not provided for in groups
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 9/10 - Transferases (2.)
• C12N 9/88 - Lyases (4.)
• C12P 13/02 - Amides, e.g. chloramphenicol

Abstract

The present invention relates to a Janus kinase (JAK) inhibitor and to pharmaceutical composition comprising a Janus kinase (JAK) inhibitor, respectively, for use for the treatment of toxic epidermal necrolysis (TEN) and/or Stevens-Johnson-syndrome (SJS) and/or SJS/TEN overlap. The invention further relates to a method for treatment of toxic epidermal necrolysis (TEN) and/or Stevens-Johnson-syndrome (SJS) and/or SJS/TEN overlap comprising application of a Janus kinase (JAK) inhibitor to a patient.

IPC Classes  ?

• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 17/00 - Drugs for dermatological disorders
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

Disclosed is an optical fiber feedthrough (10) configured to feed through optical fibers (1) between an interior and exterior of evacuable vacuum chamber (30). The feedthrough includes at least one mounting flange (11a, 11b) configured for pressure-tight fastening to vacuum chamber and includes passage openings (12a, 12b) configured for pressure-tightly receiving a respective optical fiber. The passage openings are each provided with a sealing receptacle (13a, 13b) and a sealing element (14a, 14b) arranged therein for pressure-tightly receiving the respective optical fiber. A compression device (15a, 15b) is connected to each mounting flange, which is configured to compress the respective sealing elements axially along the respective passage openings. Also disclosed is an optical fiber assembly (20) including the feedthrough and optical fibers, and a method for passing a plurality of optical fibers between an interior and exterior of an evacuable vacuum chamber using the aforementioned feedthrough.

IPC Classes  ?

• G02B 6/44 - Mechanical structures for providing tensile strength and external protection for fibres, e.g. optical transmission cables

Abstract

Disclosed is a method of manufacturing an optical fiber, the method comprising: providing a fiber manufacturing intermediate product, the fiber manufacturing intermediate product comprising: (i) a hollow core cane comprising a first jacket with a hollow inner structure, wherein a plurality of capillaries are fused to the first jacket within the hollow inner structure; and (ii) a second jacket around the hollow core cane; roughening an outer surface of the second jacket over a portion (310) of the second jacket; coupling an end of the fiber manufacturing intermediate product to a pressure connector (402); and drawing a hollow core photonic crystal fiber from the fiber manufacturing intermediate product.

IPC Classes  ?

• C03B 37/027 - Fibres composed of different sorts of glass, e.g. fibre optics
• C03B 37/012 - Manufacture of preforms for drawing fibres or filaments

Abstract

An apparatus for determining an arrhythmia of a living heart comprises a signal evaluation device receiving a signal representing a present electric activity of the heart, and determining a frequency spectrum of the signal. The apparatus further comprises a pulse generator generating a sequence of electric pulses to be applied to the heart at a pulse repetition frequency that depends on the frequency spectrum and decreases by at least 20% over the sequence.

IPC Classes  ?

• A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
• A61N 1/37 - MonitoringProtecting
• A61N 1/39 - Heart defibrillators

Abstract

A method of manufacturing a preform for use in the manufacturing process of a hollow-core photonic crystal fiber, the method comprising: (i) providing an elongated preform jacket with a hollow inner structure, the elongated preform jacket having a first and second end; (ii) inserting a hollow capillary preform into the hollow inner structure such that the hollow capillary preform is in contact with the hollow inner structure at a contact position and protrudes out of the hollow inner structure at the first end and at the second end; (iii) at the first end, locally heating a protruding portion of the hollow capillary preform; (iv) bending the protruding portion around the first end of the preform jacket; and (v) applying additional heat to a portion of the hollow capillary preform that is bent around the elongated preform jacket to fuse it to an outer surface of the elongated preform jacket.

IPC Classes  ?

• C03B 37/012 - Manufacture of preforms for drawing fibres or filaments
• C03B 37/027 - Fibres composed of different sorts of glass, e.g. fibre optics
• C03B 23/06 - Re-forming tubes or rods by bending
• C03B 23/207 - Uniting glass rods, glass tubes, or hollow glassware

Abstract

In order to map the surface of a macromolecule, at least one fluorescent probe is introduced into a medium in which the macromolecule is embedded or will be embedded. Then, a plurality of spatial positions of the at least one fluorescent probe with regard to the macromolecule are determined via localization of the at least one singularized fluorescent probe with a simple standard deviation of no more than 2 nm. For this purpose, fluorescence light photons emitted by the singularized fluorescent probe are recorded. In addition, a bounding surface bounding the determined spatial positions with regard to the macromolecule is determined; and a three-dimensional map of at least a part of the surface of the macromolecule is generated from the bounding surface.

IPC Classes  ?

• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/1429 - Signal processing
• G01N 15/1434 - Optical arrangements

Abstract

According to a method of manufacturing a magnetic memory device, various types of magnetic memory devices can be manufactured at low cost by manufacturing a plurality of magnetic modules by using a delamination phenomenon of pattern segments and stacking the plurality of magnetic modules to complete a stacked memory device.

IPC Classes  ?

• H10N 50/01 - Manufacture or treatment
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 50/10 - Magnetoresistive devices

Abstract

A drug delivery system comprising a liposome having (a) a lipid bilayer enclosing an aqueous volume, wherein the lipid bilayer comprises i) between 30 and 75 mol percent of at least one encapsulating agent; ii) between 1 and 20 mol percent of an acid-cleavable polyethylene glycol conjugated lipid; iii) between 15 and 45 mol percent of at least one fusogenic agent, and (b) a therapeutic agent or a pharmaceutically acceptable salt thereof, encapsulated within the aqueous volume; wherein the encapsulating agent is a cationic lipid and/or a lipidated polypeptide; and wherein the liposome has a Z-Average diameter size range comprised between 20 nm and 200 nm, as determined by dynamic light scattering.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 38/46 - Hydrolases (3)
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention relates to a system (100) for assessing neurocognitive functioning, comprising a task component (101) configured to provide a task, in particular a cognitive task to a user; a capture component (102) configured to capture biomarker data of a biomarker of the user; and a processing component (103) configured to generate a biomarker response profile based on the biomarker data. The present invention further relates to a method for assessing neurocognitive functioning, comprising the steps of providing a task to a user; capturing biomarker data of a biomarker of the user; generating a biomarker response profile based on the biomarker data.

IPC Classes  ?

• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The invention relates to a system (100) for assessing anhedonia, comprising a task component (101) configured to provide a reward task to a user; a capture component (102) configured to capture biomarker data of a biomarker of the user in response to the reward task; and a processing component (103) configured to generate a biomarker response profile based on the biomarker data. The invention further relates to a method for assessing anhedonia, comprising the steps of providing a reward task, capturing biomarker data of a biomarker of the user in response to the reward task; and generating a biomarker response profile based on the biomarker data.

IPC Classes  ?

• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The invention relates to a safety apparatus (100) for monitoring a light path of a laser beam (1) and for interrupting the laser beam (1) in response to an object (2) approaching the laser beam (1), said apparatus comprising: at least one light barrier device (200) having a light source device (210) arranged to generate a safety light field (3) that extends along at least one longitudinal axis z extending in parallel with the light path of the laser beam (1), and having a sensor device (220) which has at least one sensor element (221) and which is arranged to detect the safety light field (3) and to generate a sensor signal (4) that can be varied by means of at least partial covering of the safety light field (3) by the object (2); and an interruption device (300) which is coupled to the at least one light barrier device (200) and which is arranged to interrupt the laser beam (1) according to a change in the sensor signal (4) of the at least one light barrier device (200). The invention also relates to a laser apparatus which is equipped with the safety apparatus (100), to applications of the safety apparatus (100), and to a method for monitoring a light path of a laser beam (1).

IPC Classes  ?

• G02B 26/04 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light by periodically varying the intensity of light, e.g. using choppers
• F16P 3/14 - Safety devices acting in conjunction with the control or operation of a machineControl arrangements requiring the simultaneous use of two or more parts of the body with means, e.g. feelers, which in case of the presence of a body part of a person in or near the danger zone influence the control or operation of the machine the means being photocells or other devices sensitive without mechanical contact
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors

Abstract

The present invention relates to a computer-implemented method of calculating the ranges of concentrations, of fluxes, or of reaction rate constants in a network of chemical reactions.

IPC Classes  ?

• G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• G06F 17/16 - Matrix or vector computation

Abstract

The invention relates to a method for determining at least one mass (m) that is lifted and/or carried by a user (B), with the aid of a technical device (100), preferably in the form of a smart watch and/or a sports wristband, the technical device (100) having at least one sensor (10) that is configured to measure at least one dynamic motion parameter, wherein sensor signals of the at least one sensor (10), are processed and/or analyzed to determine at least one mass (m) lifted and/or carried by the user (B).

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01L 1/00 - Measuring force or stress, in general

Abstract

The present invention provides a Computer-implemented method for determining a mapping between point patterns and corresponding coordinates in a 2D latent space, the method comprising: - for each of a set of representative point patterns, determining a set of feature vectors, wherein features of the feature vectors represent perceptual properties, - determining a dissimilarity matrix between the feature vectors of each of representative point patterns, and - performing dimensionality reduction using the dissimilarity matrix to determine the mapping from the representative point patterns to the 2D latent space.

IPC Classes  ?

• G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
• G06V 10/77 - Processing image or video features in feature spacesArrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]Blind source separation
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 40/16 - Human faces, e.g. facial parts, sketches or expressions

Abstract

A composition comprising (a) a therapeutic agent or a pharmaceutically acceptable salt thereof; (b) a PEG-monoorthoester-lipid; (c) an amphiphilic lipid; (d) a cationic lipid and/or a beta-alanyl-prolyl-cysteine methyl ester; and optionally (e) a steroid and/or a ceramide and/or DOPE. The composition for use as a medicament.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 38/46 - Hydrolases (3)
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

The present invention relates to nanocontainers for the synergistic transport of lipophilic and hydrophilic active ingredients or detection reagents. In particular, the nanocontainers according to the invention offer a possibility for diagnosing and/or treating diseases with combinations of active ingredients (therapy) and detection reagents (diagnostics), which have different solubility properties. The present invention further relates to a method for producing the nanocontainers according to the invention.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
• A61K 31/4164 - 1,3-Diazoles
• A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61K 31/5383 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/65 - Tetracyclines
• A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
• A61K 49/00 - Preparations for testing in vivo
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes

Abstract

A method of operating a magnetic memory device includes: (i) applying a first current to a free layer of a magnetic tunnel junction structure, which includes a magnetic translation unit (MTU) extending between a first magnetic pad and a second magnetic pad, and a tunnel barrier layer and a pinned layer stacked on the MTU, so that a multi-domain is established within the MTU, (ii) applying a magnetic field to the free layer so that the magnetization direction of the MTU switches to become anti-parallel to the magnetization directions of the first magnetic pad and the second magnetic pad, (iii) applying a second current to the free layer so that a portion of the multi-domain penetrates into the first magnetic pad, and (iv) applying another magnetic field to the free layer so that the magnetization direction of the first magnetic pad switches.

IPC Classes  ?

• G11C 19/08 - Digital stores in which the information is moved stepwise, e.g. shift registers using magnetic elements using thin films in plane structure
• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 50/10 - Magnetoresistive devices
• H10N 50/80 - Constructional details

Abstract

The present invention relates to an electrode comprising or consisting of an electrocatalyst, the electrocatalyst comprising a metal boride, wherein the metal boride comprises at least one element M1 selected from Ti, Zr and Hf, and at least one element M2 selected from Co, Ni, Ru, Rh, Pd, Ir and Pt; and the metal boride contains more than 10 atomic % of M2. The present invention also provides an electrode obtainable by subjecting the electrode to an electrocatalytic reaction. It also relates to an electrolyzer comprising said electrode. It is also concerned with a method for producing an electrode, and use of an electrode in an electrocatalytic reaction.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• B01J 21/02 - Boron or aluminiumOxides or hydroxides thereof
• C25B 11/047 - Ceramics
• C25B 11/067 - Inorganic compound e.g. ITO, silica or titania
• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
• H01M 4/90 - Selection of catalytic material
• C01B 35/04 - Metal borides

Abstract

The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2 and that have been selected for potent cross-reaction and cross-neutralization between the original Wuhan strain and the Alpha, Beta, Gamma, Delta, and Mu variants of concern.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The invention relates to a method to query a molecular interaction between a first and a second partner moiety, wherein the first partner moiety is associated to a first partial effector sequence, and the second partner moiety is associated to a second partial effector sequence. The first and second partial effector sequences constitute a functional split HaloTag system. The first partner is a peptide sequence encoded by a polynucleotide sequence, and is physically associated with the polynucleotide sequence. The method according to the invention comprises the steps of: a) contacting the first and the second partner moiety in the presence of a HaloTag substrate covalently linked to a separation function; b) separating the first partner moiety being attached to the separation function; c) determining a molecular interaction between the first partner moiety and the second partner moiety by detecting the presence of the polynucleotide sequence.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A three-dimensional arrangement of nanoscopic devices, the arrangement comprises a scaffold structure; and a plurality of nanoscopic devices, the nanoscopic devices being configured to exhibit a nonreciprocal transmission probability of electron quantum wave packets, wherein the nanoscopic devices are attached to the scaffold structure, wherein a majority of the nanoscopic devices are oriented with one and the same transmission direction of higher transmission probability of the electron quantum wave packets.

IPC Classes  ?

• H10N 19/00 - Integrated devices, or assemblies of multiple devices, comprising at least one thermoelectric or thermomagnetic element covered by groups
• H10N 10/01 - Manufacture or treatment
• H10N 10/82 - Interconnections

Abstract

Disclosed is an acoustic trapping assembly (100) comprising a focused ultrasound transducer (102) and a plurality of hollow microrobots (110). The focused ultrasound transducer (102) is configured for generating an acoustic pressure maximum within a focal area (106) of a focused ultrasound beam (104) emitted by the focused ultrasound transducer (102) with the plurality of hollow microrobots (110) being acoustically trapped within the acoustic pressure maximum under fluid flow in a fluidic medium (120). The hollow microrobots (110) comprise solid shells (112) filled with gas.

IPC Classes  ?

• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 9/50 - Microcapsules

Abstract

The present invention relates to methods and devices for transmitting packets in a data center network (DCN), the data center comprising a multitude of host servers, a multitude of top-of- rack, ToR, switches connected to the host servers and an optical network fabric connected to the multitude of top-of-rack switches, wherein the optical network fabric operates according to a given schedule, wherein the given schedule defines, for each time slice in a sequence of time slices, which pairs of top-of-rack switches are connected by a dedicated optical circuit established by an optical controller of the optical network fabric for said time slice, wherein a top-of- rack switch: synchronizes to another top-of-rack switch; receives a packet at an ingress port; and sends the packet to an egress port. According to the invention, synchronizing comprises sending a synchronization message to said another top-of-rack switch in-band.

IPC Classes  ?

• G06F 1/04 - Generating or distributing clock signals or signals derived directly therefrom
• H04J 3/06 - Synchronising arrangements
• H04Q 11/00 - Selecting arrangements for multiplex systems

Abstract

The present invention relates to a method and system for producing adenosine triphosphate (ATP) through an acid/aldehyde-ATP (AAA) cycle in an electrochemical cell.

Abstract

The present disclosure relates to a device and a method for quantum computing using a plurality of neutral atoms in an array of optical traps, wherein a first internal state of the neutral atoms serves as qubit ground state |o>, and a second internal state serves as qubit excited state |1>. According to the present disclosure, a local single-qubit gate operation on a qubit may be performed comprising locally and selectively illuminating the qubit prepared in a superposition state |s> of qubit ground state |o> and qubit excited state |1> with a qubit addressing laser at a first qubit addressing laser frequency to cause a differential Stark shift for the qubit ground state |o> and the qubit excited state |1>, Further, a local two-qubit gate operation may be performed on a pair of qubits comprising locally and selectively illuminating the pair of qubits prepared in the qubit ground state |o> with the qubit addressing laser at a second qubit addressing laser frequency for coupling the pair of qubits to a Rydberg state |r> of the neutral atoms preferably via a third internal state c> of the neural atoms that can serve as an intermediate state of a two-photon transition from the qubit ground state |o> to the Rydberg state |r>.

IPC Classes  ?

• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

The present invention relates to polyproline-based block copolymers and compositions thereof, which e.g. are useful for delivering active ingredients, including nucleic acids, and/or imaging agents to target cells or tissues.

IPC Classes  ?

• C08G 69/10 - Alpha-amino-carboxylic acids
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor

Abstract

The present invention relates to a nucleic acid-based assembly comprising: at least one nucleic acid aptamer, and at least one nucleic acid motif designed to physically capture a drug. The nucleic acid motif may comprise one or more photo-responsive moieties that effect the release of the drug upon irradiation. The aptamer and the nucleic acid motif each can be covalently linked to one or more lipids, and the lipid-modified aptamer and nucleic acid motif may form the assembly through noncovalent interaction. The invention further relates to use of the nucleic acid-based assembly in the treatment of cancer.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

The present invention relates to a modified cell, in particular a modified blood cell, having a cell membrane encapsulating a lumen of the modified cell, wherein a functional lipid is incorporated into the cell membrane, wherein the functional lipid has a bonding site capable of bonding to a molecule having a functional motif, and wherein the bonding site is located on an external surface of the cell membrane. Further, the present invention concerns a pharmaceutical composition, the use of the modified cell and/or the pharmaceutical composition for use as a medicament or as a contrast agent as well as a method of modifying a cell.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/078 - Cells from blood or from the immune system

Abstract

The present invention relates to certain macrocyclic compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment or prevention of a disease associated with and/or caused by proteasome or immunoproteasome, selected from a cancer, an infectious disease, an inflammatory disease, and autoimmune disease. The present invention relates to certain macrocyclic compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment or prevention of a disease associated with and/or caused by proteasome or immunoproteasome, selected from a cancer, an infectious disease, an inflammatory disease, and autoimmune disease.

IPC Classes  ?

• A61K 31/439 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/5386 - 1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
• A61P 35/00 - Antineoplastic agents
• C07D 498/08 - Bridged systems
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

A method of determining nanoparticle properties of nanoparticles (2) included in a sample (1), comprising the steps of collecting sequential frames of images by employing an interferometric microscope device (110), wherein the sample (1) is illuminated with illumination light (3) from a coherent light source device (111) and the images are created by scattering light (4) from the nanoparticles (2) superimposed with non-scattered reference light, said scattering light and reference light having a wavelength larger than a cross-sectional dimension of the nanoparticles (2), tracking the nanoparticles (2) in the sequential frames of images, wherein at least one interferometric point spread function (iPSF) feature of each of the nanoparticles (2) is established and nanoparticle trajectory motion data are determined for each nanoparticle (2), comprising the nanoparticle positions in each frame, for each nanoparticle (2), calculating a nanoparticle size d from the trajectory motion data of the nanoparticle and calculating an interferometric nanoparticle contrast from the at least one iPSF feature of the nanoparticle.

IPC Classes  ?

• G01N 15/1433 - Signal processing using image recognition
• G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials
• G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/1434 - Optical arrangements

Abstract

The present invention concerns a lithium metal electrode, in particular for a lithium ion battery, comprising a three-dimensional network of metal fibers, wherein the metal fibers are directly in contact to one another, wherein the metal fibers have a thickness and/or width in the range of 0.25 to 200 μm, and wherein metallic lithium is provided on the surface of the metal fibers of the tree-dimensional network of metal fibers. Further, the present invention concerns a Method of manufacturing a lithium metal electrode, wherein the method comprises the steps of a) providing a three-dimensional network of metal fibers, wherein the metal fibers are directly in contact to one another, wherein the metal fibers have a thickness and/or width in the range of 0.25 to 200 μm; and b) providing a layer of metallic lithium on the fibers of the three-dimensional network of metal fibers.

IPC Classes  ?

• H01M 4/66 - Selection of materials
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/04 - Processes of manufacture in general
• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/70 - Carriers or collectors characterised by shape or form
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

A shutter device (100) comprises a backplane (10), a front cap (20), and a single shutter blade (30) mounted between the backplane (10) and the front cap (20), wherein the shutter blade (30) is connectable with a drive mechanism and movable between an open state and a closed state.

IPC Classes  ?

• G02B 26/02 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light
• G02B 21/16 - Microscopes adapted for ultraviolet illumination
• G02B 21/00 - Microscopes

Abstract

The present invention relates to VHH antibodies that specifically bind to components of nuclear pore complexes of human cells and other species. Further, the present invention relates to the labelling of VHH antibodies through maleimide chemistry and ectopic cysteine residues. Further, the present invention relates to a method for forming a stabilizing, structural disulfide bond in initially reduced VHH antibodies.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans

Abstract

The present invention relates to a method for increasing the frequency of meiotic crossover in a plant, plant part, plant tissue culture or plant cell comprising inhibiting in said plant, plant part, plant tissue culture or plant cell the expression and/or the function of the proteins ZYP1 and RECQ4. The present invention furthermore relates to a plant, plant part, plant tissue culture or plant cell, wherein the expression and/or the function of the proteins ZYP1 and RECQ4 is inhibited.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The present invention relates to a method for identifying and separating a specific component of interest from a plurality of components, the method comprises the steps of: A) providing a dispersion comprising the plurality of components, optionally enclosed in compartments, and a photoresist, wherein among the plurality of components at least one portion shows a factor of interest; B) scanning of the dispersion for at least one factor of interest to identify said at least one portion among the plurality of components or optionally of the compartments and selecting those components or optionally compartments of interest and attributing a location to the components or optionally compartments of interest within the dispersion; C) applying a light to at least one part of the dispersion for curing said photoresist either attributed to the components of interest or not attributed to the components of interest; and D) separating a component from parts of the dispersion with cured photoresist from components from other parts of the dispersion with uncured photoresist. Further, the present invention relates to a device configured to carry out the method according to any one of the preceding claims.

IPC Classes  ?

• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/1429 - Signal processing
• G01N 15/1433 - Signal processing using image recognition
• G01N 15/1434 - Optical arrangements
• C12M 1/00 - Apparatus for enzymology or microbiology
• G01N 15/10 - Investigating individual particles
• C08F 299/02 - Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers from unsaturated polycondensates

Abstract

A method for fabricating a magnetic device comprises providing a layer stack, the layer stack comprising a substrate, a first ferromagnetic layer disposed above the substrate, the first ferromagnetic layer comprising a uniaxial magnetic anisotropy including an easy axis, a non-magnetic layer disposed on the first ferromagnetic layer, a second ferromagnetic layer disposed on the non-magnetic layer, the second ferromagnetic layer comprising a unidirectional anisotropy, and an antiferromagnetic layer disposed on the second ferromagnetic layer, the antiferromagnetic layer comprising a Néel temperature TN; heating the layer stack above the Néel temperature TN of the antiferromagnetic layer; applying a magnetic field HCL to the layer stack, the magnetic field HCL comprising a magnetic field direction having an arbitrary angle with respect to the easy axis; cooling the layer stack below the Néel temperature TN of the antiferromagnetic layer with the magnetic field HCL applied; and removing the magnetic field HCL.

IPC Classes  ?

• H10N 50/01 - Manufacture or treatment
• H10N 50/10 - Magnetoresistive devices
• H10N 50/85 - Materials of the active region
• H10N 60/01 - Manufacture or treatment
• H10N 60/85 - Superconducting active materials

Abstract

The present invention relates to a source (100) for providing a directed flow of source material (80) thermally evaporated and/or sublimated by a laser beam (68) and emerging in a flow direction (84) from the source (100) at a flow opening (90) of a source chamber (10) of the source (100). Further, the present invention relates to a deposition system (200) for coating of a substrate (222), comprising a reaction chamber (210) enclosing a reaction volume (212), a substrate arrangement means (220) for arranging the substrate (222) to be coated within the reaction volume (212), and said source (100) for providing a directed flow (82) of evaporated and/or sublimated source material (80), wherein the reaction chamber (210) comprises a source opening (230) in a reaction chamber wall (216) of the reaction chamber (210) such that a line of sight (240) between the source opening (230) and the substrate (222) to be coated is free, and wherein the source (100) is sealingly arranged with its flow opening (90) at the source opening (230).

IPC Classes  ?

• C23C 14/28 - Vacuum evaporation by wave energy or particle radiation
• C23C 14/52 - Means for observation of the coating process
• C23C 14/24 - Vacuum evaporation
• C23C 14/54 - Controlling or regulating the coating process
• C23C 14/56 - Apparatus specially adapted for continuous coatingArrangements for maintaining the vacuum, e.g. vacuum locks
• C30B 23/00 - Single-crystal growth by condensing evaporated or sublimed materials

Abstract

The present invention relates to a method for finding global regulators in order to induce or increase production of target secondary metabolites. The method comprises providing a bacterium indicator strain producing two fluorescent reporter signals under the same control of two different biosynthetic gene clusters (BGC), preferably highly expressed BGC, performing random mutagenesis in said bacterium indicator strain, and selecting mutant bacteria not producing said reporter signals. The invention also relates to a method to activate the production of target secondary metabolites, and to a CRISPR/Cas based single plasmid to delete or inactivate a global regulator and/or activate a BGC. Finally, the inventive method can be performed in high-throughput format allowing to speed-up the procedure.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/65 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression using markers
• C12N 15/67 - General methods for enhancing the expression
• C12P 1/04 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes by using bacteria
• C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
• C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Abstract

The invention relates to a flange (10) made of an aluminum alloy, wherein the flange (10) is arranged sealedly or can be arranged sealedly at an opening (104) in a chamber wall (102) of a vacuum and/or reaction chamber (100), and wherein the flange (10) has a peripheral and planar sealing surface (20) for sealing the opening (104) in the vacuum and/or reaction chamber (100) with respect to the surroundings, which sealing surface is adjoined by a cutting edge (30) for a knife-edge seal (40). The invention also relates to a flanged joint (50) comprising a first flange element (52), a second flange element (54), a sealing ring (60), and a clamping device (70), wherein the first flange element (52) and the second second flange element (54) each have a cutting edge (30) for a knife-edge seal (40), wherein the sealing ring (60) is made of a softer material than the cutting edges (30) and can be arranged between the first flange element (52) and the second second flange element (54), and, in order to seal the flanged joint (50), the first flange element (52) and the second flange element (54) can be pressed against one another by means of the clamping device (70), so that the cutting edge (30) of the first flange element (52) and the cutting edge (30) of the second flange element (54) are pressed into the sealing ring (6) from opposing sides. The invention also relates to a vacuum and/or reaction chamber (100) having a chamber wall (102) and an opening (104) in the chamber wall (102), wherein the vacuum and/or reaction chamber (100) also has a flange (10) of this kind for the opening (104), wherein the flange (10) is arranged sealedly at the opening (104). The invention also relates to a system (200) for thermal laser epitaxy (TLE), comprising at least one vacuum and/or reaction chamber (100) of this kind, wherein the vacuum and/or reaction chamber (100) has a chamber wall (102) having one or more openings (104) at each of which one flange (10) is arranged.

IPC Classes  ?

• F16L 23/032 - Flanged joints the flanges being connected by members tensioned axially characterised by the shape or composition of the flanges
• F16L 23/20 - Flanged joints characterised by the sealing means the sealing means being rings made exclusively of metal
• C22C 21/06 - Alloys based on aluminium with magnesium as the next major constituent
• C22C 21/12 - Alloys based on aluminium with copper as the next major constituent
• F16L 55/115 - Caps
• F16J 15/08 - Sealings between relatively-stationary surfaces with solid packing compressed between sealing surfaces with exclusively metal packing

Abstract

The present invention relates to racetrack memory array devices, and more specifically, to a manufacturing method of racetrack memory arrays with integrated magnetic tunnel junction for read/write.

IPC Classes  ?

• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• H10N 50/01 - Manufacture or treatment
• H10N 50/10 - Magnetoresistive devices
• H10N 50/85 - Materials of the active region

Abstract

The present invention relates to a method for non-invasive production of defined structures inside compartments, wherein the method comprises the steps of: providing a compartment having an inside filled with a liquid, comprising a photoresist, and applying light to the inside of the compartment including the photoresist, wherein the light has a focal point inside the compartment and initiates a chemical reaction of the photoresist at the focal point, creating a defined structure. Further, the present invention relates to a compartment, having an inside, surrounded by a compartment wall, wherein the compartment comprises a defined structure obtainable by a method according to any one of the preceding claims.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• B29C 64/135 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask the energy source being concentrated, e.g. scanning lasers or focused light sources
• B29K 71/00 - Use of polyethers as moulding material
• B33Y 10/00 - Processes of additive manufacturing
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• G03F 7/029 - Inorganic compoundsOnium compoundsOrganic compounds having hetero atoms other than oxygen, nitrogen or sulfur

Abstract

The present invention provides a Glycolyl-CoA Carboxylase (GCC), wherein said GCC is characterized in that: it comprises an amino acid sequence having at least 60 % sequence identity to SEQ ID NO: 1, and it has one or more amino acid substitutions, deletions or insertions at a position selected from the group consisting of positions 20 and 100 in the amino acid sequence shown in SEQ ID NO: 1 or at a position corresponding to any of these positions, preferably wherein the GCC has an improved activity over a reference GCC, preferably wherein the reference GCC comprises the amino acid sequence of SEQ ID NO: 1.

IPC Classes  ?

• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes

Abstract

The present invention relates to a method for genetically engineering the genome of phages at a target locus by CRISPR-Cas, where the phases the genome of which is to be genetically engineered are comprises in a bacterial cell, a L-form bacterium, a cell-free transcription-translation system (TXTL) system or a bacterial cell lysate expressing a Tet-like protein.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 9/22 - Ribonucleases
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase

Abstract

In a first aspect the present invention relates to a system for continuous measurement of osmolarity in situ. Said system comprises phase-separated membrane enclosed compartment as the sensor in osmolarity; detection means: a processing unit, and, optionally, an output unit of absolute or relative osmolarity and/or osmolarity changes. Further, the use of the phase-separated membrane enclosed compartment, whereby the membrane is permeable to a solvent and non-permeable to the osmotically active substance for non-invasive osmolarity measurement in a liquid system is described. In addition, a method for determining osmolarity and/or osmolarity change in a system is provided including the phase-separated membrane enclosed compartment, whereby the membrane is a permeable to a solvent and non-permeable to the osmotically active substance. Finally, a set of phase-separated membrane enclosed compartment, whereby the membrane is permeable to a solvent and non-permeable to the osmotically active substance, having predetermined different inner osmolarities useful for calibrations of osmolarity of an osmolarity measuring system is disclosed.

IPC Classes  ?

• G01N 13/04 - Investigating osmotic effects

Abstract

The invention relates to ancestral citrate synthase proteins which are capable of forming at least 3 different complexation states simultaneously. The invention further relates to compositions comprising the ancestral citrate synthase proteins, use of the ancestral citrate synthase proteins or compositions, nucleic acids encoding the ancestral citrate synthase proteins, and methods of purifying the ancestral citrate synthase proteins.

IPC Classes  ?

• C12N 9/10 - Transferases (2.)
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

The present invention relates to a method for manipulating domain walls (DWs) in a magnetic ribbon, which method comprises imposing a curvilinear 3D structure upon at least one region of the magnetic ribbon. Moreover, the invention relates to a curvilinear 3D magnetic ribbon, which extends between two ends and which has at least one twisted region between its two ends wherein the twisted region exhibits an absolute torsion angle over its length of 1-70°, and the torsion angle has an increase per unit length of 0.5-60°.

IPC Classes  ?

• H10N 50/00 - Galvanomagnetic devices
• H10N 50/01 - Manufacture or treatment
• H10N 50/80 - Constructional details
• H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties

Abstract

The present disclosure relates to an electronic tag for behavioural monitoring of animals, the electronic tag comprising a microprocessor and at least one sensor. The electronic tag is configured to obtain, via the at least one sensor, movement data of an animal to which the electronic tag is attached and to determine, based on the obtained movement data, a behaviour of the animal. The disclosure further encompasses a corresponding method as well as an ear tag.

IPC Classes  ?

• A01K 29/00 - Other apparatus for animal husbandry
• A01K 11/00 - Marking of animals
• A01K 27/00 - Leads or collars, e.g. for dogs

Abstract

A method sequentially transmits signals of polarization states of light through an optical fiber. The optical fiber being a polarization preserving optical fiber. For each signal, a signal state is prepared as one out of a set of at least two non-orthogonal polarization states of light and sent through the optical fiber from a sender site to a receiver site. A method for quantum key distribution using polarization states of light is performed, wherein an alphabet of elementary information values is encoded in a set of non-orthogonal polarization states of light such that each elementary information value is represented by at least one of the polarization states. A classical message of elementary information values out of the alphabet is prepared, wherein the respective polarization states corresponding to the elementary information values of the classical message are prepared at a sender site as signal states.

IPC Classes  ?

• H04B 10/532 - Polarisation modulation
• H04B 10/25 - Arrangements specific to fibre transmission
• H04B 10/70 - Photonic quantum communication

Abstract

The invention relates to an optical component comprising a metasurface, wherein the metasurface comprises a repeating pattern of unit cells, wherein each unit cell comprises at least two different scattering structures, wherein first scattering structures are at least partially contacting a first substance having a first refractive index and second scattering structures are at least partially contacting a second substance, which differs from the first substance, wherein the second substance provides a refractive index which is variable depending on an electrical control signal, wherein a plurality of pairs of first scattering structures contacting the first substance and second scattering structures contacting the second substance are arranged row-wise on electrodes, wherein electrodes supporting neighboring rows of pairs of first and second scattering structures are electrically separated from each other, and a LIDAR system comprising such an optical component. Furthermore, the invention relates to a method for amending a deflection angle of such an optical component.

IPC Classes  ?

• G02F 1/29 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the position or the direction of light beams, i.e. deflection

Abstract

The present invention relates to novel inhibitors of α-hemolysin of formula (I) and the use thereof for the prophylaxis and treatment of infections caused by Staphylococcus aureus; especially S. aureus lung infections. The present invention relates to novel inhibitors of α-hemolysin of formula (I) and the use thereof for the prophylaxis and treatment of infections caused by Staphylococcus aureus; especially S. aureus lung infections.

IPC Classes  ?

• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
• A61K 31/554 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
• C07D 241/44 - Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 515/04 - Ortho-condensed systems

Abstract

The present invention relates to a method for the diagnosis and/or classification of a disease in a subject based on the genetic and/or epigenetic information of a sample obtained from the subject, the method comprising the steps of: a) providing data from said sample, wherein said data comprises genetic and/or epigenetic information of a random subset of genomic positions: b) assigning said sample to a sample class based on genetic and/or epigenetic information of said random subset of genomic positions by employing a computational model, which discriminates a plurality of sample classes based on genetic and/or epigenetic information of a set of genomic positions comprising said random subset, wherein the computational model has been trained with pre-determined genetic and/or epigenetic information obtained from a plurality of pre-classified samples of known diseases and wherein said computational model processes the genetic and/or epigenetic information of a genomic position of said random subset independently of the genetic and/or epigenetic information of another genomic position of said random subset, wherein said computational model is preferably in the form of a linear classifier with independent feature sampling.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16B 5/20 - Probabilistic models
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• G16B 30/10 - Sequence alignmentHomology search
• G16B 40/20 - Supervised data analysis

Abstract

A confocal microscopy apparatus 100 for imaging a sample 2 under investigation by chromatic confocal microscopy comprises an illumination source device 10 being arranged for creating illumination light 1 having an illumination spectrum covering a plurality of illumination wavelengths, a focusing device 40 including at least one focusing lens 41 being configured for focusing the illumination light 1 along an imaging axis z into a plurality of wavelength-dependent focal planes in an axial imaging range of a sample 2 to be investigated, wherein the at least one focusing lens 41 is further arranged for collecting scattering light 3 created in the focal planes of the sample 2, and a detector device 50 being arranged for spectrally resolved detecting of the scattering light 3, wherein the at least one focusing lens 41 is made of a dispersive focusing lens 41 material with an Abbe number equal to or below 8, like e. g. ZnSe. Furthermore, a confocal microscopy method for imaging a sample 2 to be investigated by chromatic confocal microscopy is described.

IPC Classes  ?

• G02B 21/00 - Microscopes

Abstract

The invention relates to novel caging-group-free photactivatable fluorescent dyes having the structural formula (I) as well as to the corresponding photoactivated fluorescent dyes having the structural formula (II). The invention further relates to the use of the photoactivatable compounds as such or after photoactivation, in particular as fluorescent tags, analytical reagents and labels in optical microscopy, imaging techniques, protein tracking, nucleic acid labeling, glycan analysis, capillary electrophoresis, flow cytometry or as a component of biosensors, or as analytical tools or reporters in microfluidic devices or nanofluidic circuitry. The invention relates to novel caging-group-free photactivatable fluorescent dyes having the structural formula (I) as well as to the corresponding photoactivated fluorescent dyes having the structural formula (II). The invention further relates to the use of the photoactivatable compounds as such or after photoactivation, in particular as fluorescent tags, analytical reagents and labels in optical microscopy, imaging techniques, protein tracking, nucleic acid labeling, glycan analysis, capillary electrophoresis, flow cytometry or as a component of biosensors, or as analytical tools or reporters in microfluidic devices or nanofluidic circuitry.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The present invention relates to self-assembling peptide amphiphiles consisting of a non-self-assembling peptide moiety having a positive net charge under physiological pH, and a hydrophobic moiety covalently coupled to the peptide moiety, wherein the peptide moiety is composed of a positively charged peptide part and a β-sheet forming peptide part, wherein the hydrophobic moiety is covalently coupled to the β-sheet forming peptide part, wherein the peptide amphiphiles self-assemble into fibrils and form μm-sized aggregates in aqueous medium, and wherein the fibrils are efficiently degradable in cells. The peptide amphiphiles of the present invention are useful as viral transduction enhancers for retroviral gene delivery into cells. Thus, the present invention further relates to the use of peptide amphiphiles as retroviral transduction enhancers in retroviral gene delivery into cells, and to methods for retroviral gene delivery into cells in presence of peptide amphiphiles.

IPC Classes  ?

• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• C07K 7/00 - Peptides having 5 to 20 amino acids in a fully defined sequenceDerivatives thereof
• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

The present invention relates to an in vitro bioassay to identify glutamine synthetase activators and inhibitors on the basis of one or more glutamine markers such as citrate, a metabolite derived from the mevalonate pathway, a glutamine responsive mRNA or proteins, such as HMGCR or SREBP2. Disclosed herein are also glutamine synthetase activators and inhibitors identified by the inventive method for use to stimulate or inhibit the synthesis of a metabolite derived from the mevalonate pathway, such as cholesterol, and to treat a disease associated with deregulated levels of said metabolite, such as cancer.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A method for switching magnetic moments in a magnetic material by: a) heating a system formed from a layer of magnetic material and a layer of a metal contacting and forming an interface with one surface of the magnetic material layer, the heating step increasing the temperature to at least 1 to 100 K above the blocking temperature of the magnetic material, b) applying current pulses having a fall time to the system at least at a point in time when the system is heated to at least 1 to 100 K above the blocking temperature of the magnetic material, thereby generating a spin texture in the magnetic material layer and c) then cooling the system to a temperature of below the blocking temperature at a cooling rate which is greater than the current pulses fall time, thereby setting the spin texture in the magnetic layer.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• G11C 11/18 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using Hall-effect devices
• H01F 10/32 - Spin-exchange-coupled multilayers, e.g. nanostructured superlattices
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 50/10 - Magnetoresistive devices
• H10N 50/85 - Materials of the active region
• H10N 52/80 - Constructional details

Abstract

The present invention relates to improved methods for obtaining purified contrast agents that are suitable for magnetic resonance imaging. The contrast agents are prepared by a method such dynamic nuclear polarization (DNP), hydrogenative parahydrogen induced polarization (PHIP), or Signal Amplification By Reversible Exchange (SABRE). High degrees of purity are achieved by performing an evaporation step to separate a signal enhanced precursor or the contrast agent from a metal catalyst or a source of radicals.

IPC Classes  ?

• A61K 49/06 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations

Abstract

The invention relates to a method of assembling a fiber network comprising a plurality of metal fibers, wherein the method comprises the following steps: The invention relates to a method of assembling a fiber network comprising a plurality of metal fibers, wherein the method comprises the following steps: providing a loose network out of the plurality of metal fibers at an assembling site; fixing the plurality of metal fibers to one another by forming contact points between the single metal fibers by heating the plurality of fibers at a heating rate higher than 50 K/min, in particular higher than 100 K/min, especially higher than 200 K/min, preferably higher than 1000 K/min, to a fixation temperature selected in the range of 50 to 98% of their melting point temperature; and cooling the plurality of fibers at a cooling rate higher than 50 K/min, preferably higher than 100 K/min. The invention further relates to a network of metal fibers comprising a plurality of metal fibers fixed one to another at contact points, wherein the metal fibers non-round cross section, in particular a rectangular, quadratic, partial circular or an elliptical cross section with a large axis and a small axis, or wherein the metal fibers comprise a round cross section, and wherein the fibers comprise a width which is generally constant along a length of the fiber such that a variation of the width of the fiber along its length is less than 40%, preferably less than 30%, in particular less than 20%.

IPC Classes  ?

• B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sinteringApparatus specially adapted therefor
• B01D 39/10 - Filter screens essentially made of metal
• B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires
• B22F 1/05 - Metallic powder characterised by the size or surface area of the particles
• B22F 1/062 - Fibrous particles
• B22F 1/08 - Metallic powder characterised by particles having an amorphous microstructure
• B22F 3/10 - Sintering only
• B22F 3/11 - Making porous workpieces or articles
• D04H 1/4234 - Metal fibres
• D04H 1/54 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving
• D04H 1/556 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving by infrared heating
• H01M 4/66 - Selection of materials
• H01M 4/80 - Porous plates, e.g. sintered carriers

Abstract

The present invention relates to a single-stranded nucleic acid molecule, comprising (a) a first nucleic acid sequence being capable of specifically hybridizing to a target complementary nucleic acid sequence, and (b) a second nucleic acid sequence that differs from the first nucleic acid sequence and is capable of transiently binding to a complementary nucleic acid sequence being labeled by an imaging molecule, wherein the first nucleic acid sequence is capable of stronger associating with its complementary nucleic acid sequence than the second nucleic acid sequence.

IPC Classes  ?

• C12Q 1/6813 - Hybridisation assays

Abstract

The present invention relates to a method for transferring a two-spin order of a molecule (e.g. parahydrogen) into a hyperpolarization of at least one heteronucleus, the method comprising the steps of: providing a molecule (e.g. parahydrogen pH2) comprising two protons and at least one heteronucleus (S3, S4), the protons having nuclear spins being coupled to a nuclear spin of the at least one heteronucleus; exposing the protons and the at least one heteronucleus to an e.g. homogeneous magnetic field (B0) in a z-direction, the z-direction forming a right-handed orthogonal coordinate system with an x- and a y-direction; and applying a sequence of radio frequency pulses to the protons and the at least one heteronucleus in order to transfer said two-spin order into the hyperpolarization of the at least one heteronucleus, wherein said sequence of radio frequency pulses comprises a first, a second, and a third group (NA, NB, NC) of 180° radio frequency pulses, wherein the first group (NA) of 180° radio frequency pulses is consecutively applied nA times during a first time interval (τA) and wherein the second group (NB) of 180° radio frequency pulses is consecutively applied nB times during a second time interval (τB) after the last first group, and wherein the third group (NC) of 180° radio frequency pulses is consecutively applied nC times during a third time interval (τC) after the last second group, wherein nA, nB, nC are integer numbers, respectively.

IPC Classes  ?

• G01R 33/46 - NMR spectroscopy
• G01R 33/28 - Details of apparatus provided for in groups
• G01R 33/54 - Signal processing systems, e.g. using pulse sequences
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques

Abstract

The present invention relates to a method for producing cytidine 5′-monophospho-N-acetyl-neuraminic acid (CMP-Neu5Ac, 1) from low-cost substrates N-acetyl-D-glucosamine (GlcNAc), pyruvate, cytidine and polyphosphate in a single reaction mixture with a set of optionally immobilized or optionally co-immobilized enzymes comprising N-acylglucoamine 2-epimerase (AGE), an N-acetylneuraminate lyase (NAL), an N-acylneuraminate cytidylyltransferase (CSS), a uridine kinase (UDK), a uridine monophosphate kinase and a polyphosphate kinase 3 (PPK3). Further, said process may be adapted to produce Neu5Acylated i.e. sialylated biomolecules and biomolecules including a saccharide, a peptide, a protein, a glycopeptide, a glycoprotein, a glycolipid, a glycan, an antibody, and a glycoconjugate, in particular, an antibody drug conjugate, and a carbohydrate conjugate vaccine, or a flavonoid.

IPC Classes  ?

• C12P 19/46 - Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 9/14 - Hydrolases (3.)
• C12N 9/88 - Lyases (4.)
• C12N 9/90 - Isomerases (5.)

Abstract

The invention relates to a method for the controlled deposition of an oxide layer (80) of a target oxide (82) on a substrate (70) in a thermal laser epitaxy (TLE) system (100), the target oxide (82) comprising a defined stoichiometry and being formed from one or more evaporated and/or sublimated source materials and oxygen originating from a gaseous oxidizing agent (54), the TLE system (100) further comprising a reaction chamber (10) and one or more laser sources (20) for providing laser beams (22) within the reaction chamber (10). Further, the invention relates to a TLE system (100) constructed for carrying out said method.

IPC Classes  ?

• C30B 23/06 - Heating of the deposition chamber, the substrate, or the materials to be evaporated
• C30B 29/16 - Oxides
• C23C 14/28 - Vacuum evaporation by wave energy or particle radiation

Abstract

The present invention relates to compounds of formula (la) that block invasion-associated pathogenicity of Salmonella Typhimurium by inhibiting the activity of the transcription factor HilD. These compounds are useful in the treatment or prophylaxis of Salmonella infections (salmonellosis).

IPC Classes  ?

• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61P 31/04 - Antibacterial agents
• A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone

Abstract

The present invention relates to a hybrid polymer comprising a polysaccharide polymer and peptide chains, to blends, hydrogels and formulations comprising the hybrid polymer, and to the use of the hybrid polymer as a rheology modifying agent.

IPC Classes  ?

• C08B 37/02 - DextranDerivatives thereof

Abstract

The present invention relates to an optical element (10) for use with a reaction chamber (70), in particular a reaction chamber (70) of a thermal laser evaporation system, the reaction chamber (70) having a chamber wall (72), with a flange (80) of the reaction chamber (70) being arranged at an opening (74) in the chamber wall (72). Further, the present invention relates to a reaction chamber (70), in particular reaction chamber (70) of a thermal laser evaporation system, comprising a chamber wall (72) enclosing a sealable reaction volume, in particular sealable with respect to the ambient atmosphere, the reaction volume fillable with a reaction atmosphere (90), the reaction chamber (70) further comprising a flange (80) arranged at an opening (74) in the chamber wall (72).

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The present invention relates to the Paclitaxel (taxol) biosynthesis pathway and in particular to methods for producing 4β,20-taxadiene, 10-deacetylbaccatin III, Baccatin III or β-phenylalanoyl-coA as well as corresponding uses. The present invention further relates to a vector, recombinant organism, a tissue, a cell, or an organelle comprising the enzymes being required for the production of 4β,20- taxadiene, 10-deacetylbaccatin III, Baccatin III or β-phenylalanoyl-coA.

IPC Classes  ?

• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/88 - Lyases (4.)
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• A01H 6/82 - Solanaceae, e.g. pepper, tobacco, potato, tomato or eggplant
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 9/10 - Transferases (2.)
• C07D 305/00 - Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
• C12P 15/00 - Preparation of compounds containing at least three condensed carbocyclic rings
• C12P 17/02 - Oxygen as only ring hetero atoms

Abstract

in vivoin vivoin vivoin vivoin vivo production of tulipalin A, and nucleic acids for expression of those enzymes.

IPC Classes  ?

• C12P 17/04 - Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/10 - Transferases (2.)
• C12N 9/88 - Lyases (4.)
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C07D 307/58 - One oxygen atom, e.g. butenolide

Abstract

The present invention is directed towards a process for the preparation of free isocyanates, which improves upon the disadvantages associated with heterogeneous catalysis. The process comprises converting formamides into the corresponding isocyanates via a catalytic dehydrogenation, which involves bringing the formamide into contact with a Group VII, VIII or IX transition metal complex and heating.

IPC Classes  ?

• C07C 263/12 - Preparation of derivatives of isocyanic acid from or via nitrogen analogues of carboxylic acids, e.g. from hydroxamic acids, involving a Hofmann, Curtius or Lossen-type rearrangement
• B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony
• B01J 31/20 - Carbonyls
• B01J 31/24 - Phosphines

Abstract

The present invention relates to a device for dispensing a measured amount of a particulate material and a method.

IPC Classes  ?

• G01F 19/00 - Calibrated capacity measures for fluids or fluent solid material, e.g. measuring cups

Abstract

In a thermal anemometry method of measuring a flow velocity (v) of a flowing fluid (5), a probe (2) is arranged in the flowing fluid (5). An electric current (4) is passed through the probe (2) to heat up the probe (2) to a temperature (Tw) that is higher than an ambient temperature (Ta). An amperage of the electric current (4) through the heated probe (2) and a voltage dropping over the heated probe (2) are measured, while the electric current (4) heating up the probe (2) is passed through the heated probe (2). The flow velocity (v) is determined using the temperature (Tw) and a change in the temperature (dTw/dt) of the heated probe (2), and an electric power (Pw) supplied to the heated probe (2) by the electric current (4), which are all determined from the amperage and the voltage, and a heat capacity (Cw) of the probe (2).

IPC Classes  ?

• G01P 5/12 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring thermal variables using variation of resistance of a heated conductor
• G01P 5/10 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring thermal variables

Abstract

The present invention relates to novel nanoporous polymer materials as well as to a facile, straight forward process for their preparation by fast mechanical deformation of highly entangled polymer articles above the glass transition temperature and subsequent quenching well below the glass transition temperature. The invention further encompasses the use of such nanoporous polymer materials in a broad variety of applications.

IPC Classes  ?

• B01D 61/14 - UltrafiltrationMicrofiltration
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 71/28 - Polymers of vinyl aromatic compounds
• C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof

Abstract

The present invention concerns a three-dimensional (3D) network of metal fibers comprising a plurality of metal fibers and a metallic compound, an electrode having said three-dimensional (3D) network of metal fibers, a battery comprising said electrode, a filter having said three-dimensional (3D) network of metal fibers, a catalyst having said three-dimensional (3D) network of metal fibers, and a method of producing a three-dimensional (3D) network of metal fibers by electroless deposition.

IPC Classes  ?

• D04H 1/4234 - Metal fibres
• B01D 39/06 - Inorganic material, e.g. asbestos fibres, glass beads or fibres
• B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires
• B22F 1/062 - Fibrous particles
• B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sinteringApparatus specially adapted therefor
• H01M 4/80 - Porous plates, e.g. sintered carriers

Abstract

The present invention is related to a method of coating a coating region (58) on a front surface (56) of a substrate (50) with a source material (40) thermally evaporated and/or sublimated from a source (30) by electromagnetic radiation (80). Further, the present invention is related to an apparatus (100) for a thermal evaporation system (200) for coating a coating region (58) on a front surface (56) of a substrate (50) with a source material (40) thermally evaporated and/or sublimated by electromagnetic radiation (80) from a source (30).

IPC Classes  ?

• C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
• C23C 16/458 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for supporting substrates in the reaction chamber
• C23C 16/48 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating by irradiation, e.g. photolysis, radiolysis, particle radiation

Abstract

Disclosed is a system (400) for crystallographic investigation of microscopic crystals, in particular microscopic crystals of biological macromolecules, the system (400) comprising: an extrusion device (410) for extruding through a nozzle (112) a jet (114) of a viscous liquid with microscopic crystals embedded therein in a propagation direction, a chamber (401) for receiving the jet (114) and a beam (406) of electromagnetic radiation irradiating the jet (114), and a catching device (100) with a collector surface (124) for receiving the jet (114) on a contact position of the collector surface (124), wherein, at the contact position, the collector surface (124) is in a translational and / or rotational motion relative to the nozzle (112) in a direction differing from the propagation direction of the jet (114).

IPC Classes  ?

• G01N 23/20 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using diffraction of the radiation by the materials, e.g. for investigating crystal structureInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materialsInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using reflection of the radiation by the materials
• G01N 23/20008 - Constructional details of analysers, e.g. characterised by X-ray source, detector or optical systemAccessories thereforPreparing specimens therefor
• G01N 1/28 - Preparing specimens for investigation

Abstract

The invention relates to a method for probing one or more properties of a material (10) at a probing spot (14) at the surface (12) of the material (10) by an untethered robot (20), the robot (20) comprising a shape changeable member (30) actuatable by temporally and/or spatially variable magnetic fields. Further, the invention relates to a robot for probing one or more properties of a material (10) at a probing spot (14) at the surface (12) of the material (10), wherein the robot (20) is untethered and comprises a shape changeable member (30) actuatable by temporally and/or spatially variable magnetic fields, wherein the robot (20) comprises two footpads (22) arranged at opposite ends of the shape changeable member (30), and the robot (20) further comprises an adhesive probing patch (50) arranged along the shape changeable member (30) between the two footpads (22). Additionally, the invention relates to a system (100) for probing one or more properties of a material (10) at a probing spot (14) at the surface (12) of the material (10), comprising a magnetic actuation system (110), an imaging system (120), a data analyzing system (130), and a robot (20).

IPC Classes  ?

• B25J 9/16 - Programme controls

Abstract

The present invention is directed towards catalysts comprising ionic liquids, their use in decarboxylation reactions and their use in tandem reduction and decarboxylation reactions. A method employing such catalysts to access phenol and aniline derivatives is also claimed. The catalysts and methods of the present invention improve upon the disadvantages associated with literature decarboxylation reactions.

Abstract

The present invention relates to an apparatus (100) for a thermal evaporation system (200) and to a thermal evaporation system (200), respectively, for coating a coating region (58) on a front surface (56) of a substrate (50) with a source material (40) thermally evaporated and/or sublimated from a source (30) by electromagnetic radiation (80). Further, the present invention relates to a method coating a coating region (58) on a front surface (56) of a substrate (50) with a source material (40) from a source (30) thermally evaporated and/or sublimated by electromagnetic radiation (80).

IPC Classes  ?

• C23C 14/28 - Vacuum evaporation by wave energy or particle radiation
• C23C 14/50 - Substrate holders

Abstract

A system for performing quantum operations comprising an optical superlattice and a plurality of optical tweezers, wherein the optical superlattice comprises a plurality of main sites; each main site comprises a storage site and an auxiliary site, each configured to hold an atom; the optical superlattice is configured to merge the storage site and the auxiliary site of each main site; and the plurality of optical tweezers is configured to move atoms provided in the plurality of main site from one main site to another main site.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

The invention relates to a DEPFET comprising: a semiconductor substrate (100) of a first conduction type, which has a first main surface (101) and a second main surface (102), which are opposite one another; a source terminal region (1s) of a second conduction type on the first main surface (101); a drain terminal region (1d) of a second conduction type; a channel region (10), which is arranged between the source terminal region (1s) and the drain terminal region (1d); a gate electrode (11), which is separated from the channel region (10) by a gate insulator (6); a rear activation region (104) of a second conduction type, which is formed on the second main surface (102); and a substrate doping increase region (2) of a first conduction type, which is formed at least under the source terminal region (1s) and under the channel region (10), the substrate doping increase region (2) having a signal charge control region (20) of the first conduction type below the gate electrode (11), in which signal charge control region the effective doping dose has a higher value than at other points of the substrate doping increase region (2) below the gate electrode.

IPC Classes  ?

• H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
• H01L 21/265 - Bombardment with wave or particle radiation with high-energy radiation producing ion implantation
• H01L 29/10 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions with semiconductor regions connected to an electrode not carrying current to be rectified, amplified, or switched and such electrode being part of a semiconductor device which comprises three or more electrodes
• H01L 29/423 - Electrodes characterised by their shape, relative sizes or dispositions not carrying the current to be rectified, amplified or switched
• H01L 29/66 - Types of semiconductor device
• H01L 31/113 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by field-effect operation, e.g. junction field-effect photo- transistor being of the conductor-insulator- semiconductor type, e.g. metal- insulator-semiconductor field-effect transistor

Abstract

During ageing, egg cells display a gradual loss of cohesin complexes. The cohesin loss eventually causes sister chromatids to separate prematurely, which leads to aneuploidy. The inventors engineered an artificial cohesion system, which is a complex for chromatid or chromosome tethering to reduce, for example, age-related premature separation of sister chromatids in eggs. The artificial cohesion system is a complex, which tethers chromosomes or chromatids so that e.g. the risk of aneuploidy is reduced. Said complex comprises (I) one or more first protein(s) and (II) one or more second protein(s), wherein the (I) first and the (II) second protein(s) each comprise (i) a chromatin-binding component, (ii) a protein-binding region being N-terminal of the chromatin-binding component, (Hi) a protein-binding region being C-terminal of the chromatin-binding component. The present invention also includes nucleic acid molecule(s) encoding said complex. Furthermore, several in vitro methods concerning the complex or the nucleic acid molecule(s) encoding said complex also form part of the invention.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C12N 15/62 - DNA sequences coding for fusion proteins
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12N 5/075 - OocytesOogonia

Abstract

The present invention provides an opto-electronic computing device, comprising one or more computation modules that each comprise: - an input layer comprising an array of photosensors for generating electrical signals based on input optical signals, - an output layer comprising an array of light emitters for generating output optical signals, - electronic circuitry for processing the generating electrical signals to generate driving signals for the array of light emitters, and - an optical layer comprising an array of optical elements for modifying the optical signals, characterized in that the device comprises one or more connection elements that pass the electrical signals from the input layer to the output board and that are oriented perpendicular to a plane of the input board.

IPC Classes  ?

• G06N 3/067 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using optical means
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

An electron microscopy apparatus (100) for time resolved low energy electron microscopy investigation of a sample (1) comprises a tip-shaped photo-emitter source (11), which is arranged for radiation-induced emission of source electrons (2) towards the sample (1), a radiation source device (20) for creating emitter excitation radiation (3) with an emitter excitation waveform and for irradiating the photo-emitter source (11) with the emitter excitation radiation (3), a sample excitation device (30) for applying a sample excitation (4) to the sample (1), and a detector device (40) for collecting sample electrons emerging at the sample (1) in response to an interaction of the source electrons (2) with the sample (1), wherein the electron microscopy apparatus (100) is configured for the time-resolved investigation of the sample (1) based on a synchronization of the sample excitation (4) applied to the sample (1) with the source electrons (2) received by the sample (1), and wherein the photo-emitter source (11) is configured for creating the source electrons (2) in response to the irradiation with the emitter excitation radiation (3) by an emission process in which the number of emitted electrons is linear with respect to the irradiated power of the emitter excitation radiation (3) on the photo- emitter source (11). Furthermore, an electron microscopy method of investigating a sample (1) by time resolved low energy electron microscopy is described.

IPC Classes  ?

• H01J 37/073 - Electron guns using field emission, photo emission, or secondary emission electron sources

Abstract

nuoA, nuoB, nuoC, nuoD,nuoE, nuoF, nuoG, nuoH, nuoI, nuoJ, nuoK, nuoL, nuoMnuoNnuoN; wherein the genetically engineered bacterium is able of oxygen uptake, i.e. the genetically engineered bacterium is able to use oxygen as electron acceptor, and wherein the bacteria is genetically engineered to produce a fermentation product in presence of oxygen. In particular, the present invention provides bacteria genetically engineered to produce lactate from glycerol or from glucose in presence of oxygen. The present invention further provides bacteria genetically engineered to produce isobutanol and/or ethanol from glycerol in presence of oxygen. Further described is a method for producing a fermentation product using the disclosed genetically engineered bacteria.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12P 7/56 - Lactic acid

Abstract

The present invention relates to compounds of the formula (I) as bifunctional protein targeting chimeras (PROTACs), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. These compounds, pharmaceutically acceptable salts, and pharmaceutical compositions thereof are useful in the treatment or prophylaxis of a cancer, an autoimmune disease, or an inflammatory disease, in paticular, associated with and/or caused by PDEdelta (PDEδ) / K-Ras or B lymphoid kinase (BLK) /Bruton´s tyrosine kinase (BTK) or cyclin-dependent kinase 9 (CDK9).

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• A61P 35/00 - Antineoplastic agents
• A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems

Abstract

Disclosed is a system for the measurement and analysis of melanopic light quantity, comprising a wearable sensor device (100), comprising a sensor array (102), the sensor array (102) comprising sensors, the sensors comprising a melanopic light sensor and at least one of a UV light sensor and an accelerometer. A data processing unit determines a behavioral pattern comprising analyzing the time-series sensor data. If further determines a melanopic light quantity within a predefined time range of the sensor data of the melanopic light sensor, determines a behavioral element of the pattern which has assigned a respective one of the melanopic light quantities suitable to at least partially compensate for the difference between a desired value and the determined value of the melanopic light quantity, and outputs a signal comprising a behavioral recommendation based on the selected behavioral element.

IPC Classes  ?

• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• A61N 5/06 - Radiation therapy using light
• G01J 1/02 - Photometry, e.g. photographic exposure meter Details
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors

Abstract

[1] The invention is based on newly derivatized protein interaction adaptor protein sequences based on SYNZIP protein domains. The improved SYNZIP domain variants of the invention were designed to be suitable for interconnecting domains of non-ribosomal peptide synthetases (NRPS) or domains of polyketide synthases (PKS), such as for generating NRPS- PKS hybrid complexes. The invention provides the SYNZIP derivative sequences, NRPS domains containing them, NRPS domain libraries thereof, as well as methods for the production and use in peptide design, screening and production.

IPC Classes  ?

• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes

Abstract

The invention relates to a sensor support (104, 1600) for a beehive panel (100, 300, 400, 500, 600, 700, 800, 954), the sensor support comprising a plurality of temperature sensors (204, 1602), the sensor support having an eigen frequency of 15 Hz – 300 Hz.

IPC Classes  ?

• G01K 1/14 - SupportsFastening devicesArrangements for mounting thermometers in particular locations
• G01K 1/02 - Means for indicating or recording specially adapted for thermometers
• A01K 47/02 - Construction or arrangement of frames for honeycombs
• A01K 47/06 - Other details of beehives, e.g. ventilating devices, entrances to hives, guards, partitions or bee escapes
• G01K 7/22 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements the element being a non-linear resistance, e.g. thermistor

Abstract

The present invention relates to certain 3-substituted 1 H-pyrrolo[2,3-b]pyridine compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment or prevention of a disease or medical condition mediated through GRK5 selected from heart disease, inflammatory and immunological disease, metabolic disease and cancer. The present invention relates to certain 3-substituted 1 H-pyrrolo[2,3-b]pyridine compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment or prevention of a disease or medical condition mediated through GRK5 selected from heart disease, inflammatory and immunological disease, metabolic disease and cancer.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A61K 31/4453 - Non-condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

The present invention relates to antisense-oligonucleotides capable of hybridizing with a region of the gene encoding Efnb2, or with a region of the mRNA encoding Efnb2, and salts and optical isomers of said antisense-oligonucleotides for use in prevention of kidney dysfunction promoted by endothelial dysfunction.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides