Abstract

A method of returning a fluorophore molecule from its non-fluorescence-excitable state to its fluorescence-excitable state, the method comprising the step of supplying the fluorophore molecule with electromagnetic radiation to stimulate a transition from the non-fluorescence- excitable state to the fluorescence-excitable state. The fluorophore transitions from its fluorescence-excitable state to its non-fluorescence-excitable state by means of a two-photon ionisation. The fluorophore is a nanographene. Moreover, uses of a nanographene fluorophore as a fluorophore in stimulated emission depletion microscopy and in calibrating a fluorescence imaging apparatus. Further, a recoverable fluorescence material comprising the fluorophore.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• G01N 21/64 - FluorescencePhosphorescence
• C07C 15/00 - Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic part

Abstract

A method comprises simulating a shape of a rod-shaped portion resulting when at least one element located at a defined position at the rod-shaped portion having a defined size is subjected to a defined external magnetic field producing the external magnetic force using a FE model of the rod-shaped portion, determining a difference between the simulated shape and an at least one desired shape of the rod-shaped portion, the rod-shaped portion having the at least one desired shape being configured to be inserted into an anatomical structure of the human being and/or an animal, and adapting the defined position, the defined size and/or the defined external magnetic field based on the determined difference using an optimization method. The steps of simulating, determining, and adapting are carried out iteratively until the determined difference is below a defined threshold.

IPC Classes  ?

• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61B 17/00 - Surgical instruments, devices or methods
• A61B 17/29 - Forceps for use in minimally invasive surgery
• A61B 18/08 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters

Abstract

The present invention relates to a method of forming a layer of a compound having a thickness selected in the range of a monolayer to several mm on a substrate, such as a single crystal wafer, the substrate being arranged in a process chamber comprising one or more sources of source material. The invention further relates to a compound optionally obtained by this method.

IPC Classes  ?

• C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
• C23C 16/40 - Oxides
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber

Abstract

The present invention relates to a sound modulator for modifying the amplitude and/or phase of an ultrasonic wave comprising: a thermally-responsive material, wherein at least one acoustic property of the thermally-responsive material is variable in response to a change in temperature; a source of ultrasonic waves, which is suitable to emit an ultrasonic pulse or a continuous ultrasonic wave toward the thermally-responsive material; a tempering device, which is in thermal communication with the thermally-responsive material, to trigger a local change of at least one property of the thermally-responsive material; a control signal, which is suitable to control heating and/or cooling of the tempering device. Furthermore, the invention relates to a method for spatially and temporally modulate the amplitude and/or phase of an ultrasonic wave, comprising the steps of: transmitting an ultrasonic wave toward a thermally-responsive material of a sound modulator, wherein at least one acoustic property of the thermally-responsive material is variable in response to a change in temperature; transmitting a control signal to the sound modulator; and tempering one or a plurality of areas of the thermally-responsive material, in response to the control signal, causing a local change of an acoustic property of the thermally-responsive material.

IPC Classes  ?

• G10K 11/26 - Sound-focusing or directing, e.g. scanning
• G10K 15/04 - Sound-producing devices
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves

Abstract

The present invention relates to compounds of formula (I), processes for their preparation, and pharmaceutical compositions containing them as the active ingredient. Compounds of the present invention may be useful as mitochondrial KV1.3 inhibitors (mitoKV1.3) to treat cancer diseases and the like, including breast, colon, and prostate tumors, melanoma, smooth muscle, and skeletal muscle cancer, chronic lymphocytic leukemia, glioblastoma, and pancreatic ductal adenocarcinoma. The present invention relates to compounds of formula (I), processes for their preparation, and pharmaceutical compositions containing them as the active ingredient. Compounds of the present invention may be useful as mitochondrial KV1.3 inhibitors (mitoKV1.3) to treat cancer diseases and the like, including breast, colon, and prostate tumors, melanoma, smooth muscle, and skeletal muscle cancer, chronic lymphocytic leukemia, glioblastoma, and pancreatic ductal adenocarcinoma.

IPC Classes  ?

• C07F 9/6553 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
• A61K 31/67 - Phosphorus compounds having sulfur as a ring hetero atom
• A61P 35/00 - Antineoplastic agents
• C07F 9/54 - Quaternary phosphonium compounds

Abstract

The present invention relates to an optical optically controlled amplitude and/or phase modulator (1) for oscillating electrical signals comprising: a signal generator (2) suitable for providing an electrical input signal (4) oscillating with a frequency (6) between 20 kHz and 50 MHz; at least one light-responsive amplitude and /or phase modulation circuit (10) that out-puts an output signal (18) whose output signal amplitude and/or phase is governed by the intensity of light (32) incident upon the modulation circuit (10); and a light source(30) directed toward the modulation circuit (10). Furthermore, the invention relates to a method for generating multiple independent oscillating electrical signals (8, 18a – 18n, 38a – 38n) for driving an array of actuating elements (20a – 20n), comprising the steps of: generating an electrical input signal (4) oscillating with a frequency (6) between 20 kHz and 50 MHz by means of a signal generator (2); providing a multitude of independent light-responsive amplitude and/or phase modulation circuits (10a – 10n); providing the electrical input signal (2) to the multitude of independent light-responsive amplitude and/or phase modulation circuits (10a – 10n); and directing a controllable pattern of light (32, 320) toward the modulation circuits (10a – 10n).

IPC Classes  ?

• B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction

Abstract

The present invention relates to a microscope stage (100) for temperature-controlled live cell imaging comprising a cooling device (110), a heat transfer plate (1) having a cylinder (131) open on both ends for accommodating a Petri dish (3) and a heat sink (2) configured as support (120), wherein the cylinder (131) protrudes into a circularly shaped opening of the support (120). In a preferred embodiment, the microscope stage (100) comprises an objective heater (40) for preventing heat loss due to the microscope objective.

IPC Classes  ?

• C12M 1/22 - Petri dishes
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• G01N 33/46 - Wood
• G02B 21/30 - Base structure with heating device
• G02B 21/28 - Base structure with cooling device
• G01N 33/483 - Physical analysis of biological material
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

The present invention relates to a reading element for a racetrack memory (RTM) that includes two superconducting electrodes (S) made of a superconducting material, which electrodes are separated by a topological metal (N) with a spin-polarized surface state, which exhibits a band inversion. The invention further relates to a method of making such a reading element as well as to its use, specifically in a racetrack memory.

IPC Classes  ?

• G11C 19/32 - Digital stores in which the information is moved stepwise, e.g. shift registers using super-conductive elements
• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• G11C 19/08 - Digital stores in which the information is moved stepwise, e.g. shift registers using magnetic elements using thin films in plane structure
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 60/01 - Manufacture or treatment
• H10N 60/12 - Josephson-effect devices
• H10N 60/80 - Constructional details

Abstract

An endoscope and a method for controlling a movement of the endoscope in a magnetic field, the endoscope comprising a tip, a set of coils surrounding the tip, and power wires arranged to supply the set of coils with electrical energy, wherein the set of coils comprises four side coils arranged around the tip such that a straight line extending orthogonally to a longitudinal direction of the tip crosses a center of the respective side coil.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
• A61B 18/08 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes

Abstract

The invention relates to an energy efficient non-volatile cryogenic memory (SUPERTRACK) which includes: a ferrimagnetic, ferromagnetic or synthetic antiferromagnetic racetrack (RT); and a superconducting shift element in proximity to the RT to move magnetic bits along the RT, wherein the superconducting shift element is a non-centrosymmetric superconductor, or is composed of a conventional superconducting material in proximity to a triplet converting material which converts the Cooper pairs of the conventional superconducting material into the triplet state, which material is selected from. Mn3X; X=Ge, Sn, Pb or Mn3XN, X=S, Ni, Ir. The invention relates to an energy efficient non-volatile cryogenic memory (SUPERTRACK) which includes: a ferrimagnetic, ferromagnetic or synthetic antiferromagnetic racetrack (RT); and a superconducting shift element in proximity to the RT to move magnetic bits along the RT, wherein the superconducting shift element is a non-centrosymmetric superconductor, or is composed of a conventional superconducting material in proximity to a triplet converting material which converts the Cooper pairs of the conventional superconducting material into the triplet state, which material is selected from. Mn3X; X=Ge, Sn, Pb or Mn3XN, X=S, Ni, Ir. Moreover, the invention relates to a method of manufacturing the memory and its use.

IPC Classes  ?

• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices

Abstract

The present invention relates to a guide RNA (gRNA) suitable for CRISPR-mediated oligonucleotide binding and/or editing comprising at least one hairpin that does not interact with a Cas enzyme wherein said hairpin forms a locked secondary structure.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 9/22 - Ribonucleases
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

A modified nanoparticle for use in a therapeutic method, wherein the therapeutic method comprises the administration of the modified nanoparticle to an organism, the targeting of the modified nanoparticles to a specific site in the organism followed by an uptake of the modified nanoparticle into a cell, and wherein the modified nanoparticle is obtainable by a process comprising the steps of i) providing a nanoparticle and ii) contacting the nanoparticle with one or more antibodies as at a pH value of less than 7.0 so as to non-covalently bind the one or more antibodies via its/their Fc region onto the surface of the nanoparticle, wherein the nanoparticle provided in step i) is made of a material having at least one protonable or deprotonable group on the surface thereof and/or the one or more targeting moieties contacted with the nanoparticle in step ii) has at least one protonable or deprotonable group.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention relates to a mannose-HSA based nanocarrier system, and a pharmaceutical composition containing the same for delivery of immunomodulatory drugs. The present invention further relates to a method of manufacturing said mannose-HSA nanocarrier system.

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61P 35/00 - Antineoplastic agents
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

The present invention relates to means and methods for connectomic screening using 3D electron microscopy. In particular, the invention relates to a chaperone block for holding one or more biological tissue samples to be analyzed, imaged and/or screened (herein also referred to as "tissue sample of interest"), wherein the chaperone block comprises at least two layers of resin, at least one layer of a chaperone sample and a multitude of cavities. The "chaperone block" is a three dimensional structure for holding the biological tissue samples of interest during analysis, imaging and/or screening, particularly using 3D EM. The "chaperon sample" is also a biological tissue sample in which the biological tissue samples of interest will be embedded ("loaded") for analysis, imaging and/or screening, particularly using 3D EM. The invention also relates to a screening sample that can be loaded into a chaperone sample as well as an apparatus for loading a chaperone block with a screening sample. The "screening sample" is the biological tissue sample of interest that has been modified (incl. embedded in a resin) so that it can be loaded into the chaperone sample on the chaperone block for EM. Furthermore, the invention relates to methods to produce a chaperone block, methods to produce a screening sample and methods for preparing a tissue sample for connectomic screening.

IPC Classes  ?

• G01N 1/36 - Embedding or analogous mounting of samples

Abstract

The present invention relates to the field of gene silencing. The present invention inter alia concerns circular RNAs, compositions and kits comprising circular RNAs, methods of producing circular RNAs, methods of inhibiting the expression of a target gene or the function of a target gene in a cell, and uses of circular RNAs and compositions comprising circular RNAs.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention relates to a method for decapping a 5'-dinucleotide-capped nucleic acid molecule, wherein the dinucleotide is linked to the nucleic acid molecule via a phosphodiester bond and the dinucleotide comprises a diphosphate, triphosphate or tetraphosphate linkage between the two nucleotides of the dinucleotide, and wherein the method comprises contacting the 5'-dinucleotide- capped nucleic acid molecule with (I) an enzyme being capable of cleaving the diphosphate, triphosphate or tetraphosphate linkage, wherein the enzyme (a) comprises or consists of the amino acid sequence of SEQ ID NO: 21, (b) comprises or consists of an amino acid sequence being at least 80%, preferably at least 90% and most preferably at least 95% identical to SEQ ID NO: 21, (c) comprises or consists of the amino acid sequence being encoded by the nucleotide sequence of SEQ ID NO: 17, or (d) comprises or consists of an amino acid sequence being encoded by a nucleotide sequence being at least 80%, preferably at least 90% and most preferably at least 95% identical to SEQ ID NO: 17; (II) a nucleic acid molecule, preferably a vector, encoding in expressible form the enzyme of (I); and/or (III) a host cell comprising the nucleic acid molecule, preferably the vector of (II).

IPC Classes  ?

• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• C12N 9/14 - Hydrolases (3.)
• C12P 19/36 - Dinucleotides, e.g. nicotineamide-adenine dinucleotide phosphate

Abstract

A method and apparatus for determining a chest function of a subject are provided. The method includes projecting, by a projector, a projection pattern including a number of optical markers onto a chest of the subject. The method further comprises capturing, by a stereo-camera system, a series of images of the projection pattern from at least two angles as the subject breathes. Each optical marker from the projection pattern is imaged from both of the at least two angles at the same time. The method further comprises tracking, by a processor, a movement over time of the projection pattern based on the captured series of images by tracking a movement over time of at least a subset of the optical markers in the captured series of images. The method also comprises determining, by the processor, at least one parameter indicative of the chest function of the subject based on a result of the tracking.

IPC Classes  ?

• A61B 5/113 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb occurring during breathing
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

The present invention relates to a method of detecting biomolecules in a sample, the method comprising: adding cells to the sample, the cells being arranged so that the biomolecules to be detected can interact with the cells to thus change one or more properties of the cells, detecting the properties of the cells, and comparing the detected properties with reference values to infer the presence or absence and/or concentration of the biomolecules.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The invention relates to a microscope comprising at least one light source for emitting light pulses for exciting a sample and an excitation beam path with a microscope objective for directing the light pulses on or into the sample, wherein the excitation beam path comprises a plurality of separate excitation channels being designed for guiding light pulses into in each case different focal spots on or in the sample, a distribution unit for distributing the light pulses to the excitation channels, a scanner for varying a region on or in the sample being irradiated by the light pulses, comprising further at least one detector for the detection of emission light emitted by the sample as an optical response to irradiation by the light pulses and a detection beam path for guiding the emission light onto the detector, and comprising a control unit for controlling at least the light source and the scanner and for evaluating the light detected by the detector. According to the invention, the microscope is characterized in that for temporally separating the respective optical responses from the irradiated focal spots, the excitation beam path is designed for irradiating the different focal spots through the excitation channels sequentially one after another, each of the excitation channels comprises an optical fiber having in each case an exit end, and, for guiding light pulses into the respectively different focal spots the exit ends of the optical fibers are arranged with an in each case different spacing with respect to a light focussing component of the excitation beam path. The invention relates furthermore to a microscopy method.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G01N 21/64 - FluorescencePhosphorescence

Abstract

Disclosed is a Janus microparticle (100). The Janus microparticle comprises at least a first portion (106) and a second portion (122). The first portion (106) comprises a ferromagnetic material and the second portion (122) comprises a piezoelectric material.

IPC Classes  ?

• H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties

Abstract

A strain measurement apparatus (100) for measuring mechanical strain in a sample (1) comprises a sample holder device (10) being arranged for accommodating the sample (1) to be investigated, an indenter device (20) including an indenter tip (21) and an actuator stage (22) carrying the indenter tip (21), wherein the actuator stage (22) is arranged for an application of a localized mechanical load along a load axis z1 via the indenter tip (21) at an indentation zone (2) of the sample (1) accommodated by the sample holder device (10), when the sample holder device (10) is in a load application position, a confocal Raman microscopy device (30) having an imaging axis z2 and being arranged for collecting at least one Raman spectrum in the indentation zone (2) of the sample (1), and a calculation device (40) being arranged for calculating at least one strain parameter based on the at least one Raman spectrum, wherein the sample holder device (10), the indenter device (20) and the confocal Raman microscopy device (30) are arranged such that the confocal Raman microscopy device (30) is capable of collecting the at least one Raman spectrum, while the sample holder device (10) is in the load application position, and the indenter device (20) and the confocal Raman microscopy device (30) are arranged such that the load axis z1 of the actuator stage (22) and the imaging axis z2 of the confocal Raman microscopy device (30) coincide. Furthermore, a strain measurement method for measuring mechanical strain in a sample (1) is described.

IPC Classes  ?

• G01N 3/06 - Special adaptations of indicating or recording means
• G01N 3/42 - Investigating hardness or rebound hardness by performing impressions under a steady load by indentors, e.g. sphere, pyramid

Abstract

The present invention relates to a method for preparing α-branched β′-hydroxy carbonyl compounds through enzymatic-catalyzed reductive aldol reaction by reacting α,β-unsaturated carbonyl donors with carbonyl acceptors in the presence of a polypeptide capable of catalyzing reductive aldol reactions and a cofactor, wherein the polypeptide is an enoyl-CoA carboxylase/reductase (Ecr). The replacement of the native CO2 electrophile in enoyl-CoA carboxylases/reductases (Ecrs) by different carbonyl acceptors advantageously creates a new-to-nature biocatalytic route towards α-branched β′-hydroxy carbonyl compounds.

IPC Classes  ?

• C12P 7/40 - Preparation of oxygen-containing organic compounds containing a carboxyl group
• C07C 51/09 - Preparation of carboxylic acids or their salts, halides, or anhydrides from carboxylic acid esters or lactones
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase

Abstract

The present invention relates to a Giant spin Hall effect material based on MxAl100-x, in which M=5d metal (Lu, Hf, Ta, W, Re, Os, Ir, Pt [=5d1-5d9], and x=15-40. Furthermore, the present invention concerns a method of making such Giant spin Hall effect material and a racetrack memory incorporating the Giant spin Hall effect material.

IPC Classes  ?

• H10N 50/85 - Materials of the active region
• C22C 21/00 - Alloys based on aluminium
• C23C 14/18 - Metallic material, boron or silicon on other inorganic substrates
• C23C 14/34 - Sputtering
• C23C 14/35 - Sputtering by application of a magnetic field, e.g. magnetron sputtering
• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• G11C 19/08 - Digital stores in which the information is moved stepwise, e.g. shift registers using magnetic elements using thin films in plane structure
• H10N 50/01 - Manufacture or treatment
• H10N 50/10 - Magnetoresistive devices
• H10N 50/20 - Spin-polarised current-controlled devices

Abstract

A connector apparatus 100 for electrically connecting conductor devices (1, 2), in particular in a superconducting condition, comprises a connector receptacle (10) for accommodating a first conductor device (1) and a second conductor device (2) with overlapping conductor sections (1A, 2A) thereof, and a first pivotable pressing clamp (20) having a first clamp shaft (21) and at least one first clamp edge (22) and being arranged for applying a contact pressure on the overlapping conductor sections (1A, 2A) of the first conductor device (1) and the second conductor device (2) so that the overlapping conductor sections (1A, 2A) directly contact each other, wherein the connector receptacle (10) comprises a base portion (11) providing a support for the first and second conductor devices (1, 2) and a bearing portion (12) being arranged adjacent to the base portion (11) for accommodating the first clamp shaft (21) of the first pressing clamp (20), and the first pressing clamp (20) is adapted for a pivoting motion between a clamp condition, wherein the at least one first clamp edge (22) presses the overlapping conductor sections (1A, 2A) against the base portion (11), and a release condition, wherein the at least one first clamp edge (22) of the first pressing clamp (20) releases the overlapping conductor sections (1A, 2A). Furthermore, an electrical conductor arrangement including the connector apparatus (100) and a method of using the connector apparatus (100) are described.

IPC Classes  ?

• H01R 4/28 - Clamped connectionsSpring connections
• H01R 4/50 - Clamped connectionsSpring connections using a cam, wedge, cone or ball
• H01R 4/68 - Connections to or between superconductive conductors

Abstract

The present invention relates to a thermally coupled correlated oxide oscillator system comprising at least two correlated oxide oscillators coupled via at least one heating element, which is inter-positioned between at least two of the at least two correlated oxide oscillators. The invention further relates to a logic device comprising a multiplicity of coupled correlated oxide oscillator / heating element cells, wherein each cell has a dimension of 1-heat-n-oscillators.

IPC Classes  ?

• H03B 9/12 - Generation of oscillations using transit-time effects using solid state devices, e.g. Gunn-effect devices

Abstract

A neutrino detection system and method based on one or more semiconductor Germanium point-contact diodes. These diodes act simultaneously as target for neutrinos or antineutrinos, that scatter off atomic nuclei, and as detectors, that register the ionization energy released in such interactions. Also included are various compact shield configurations that enhance the signal-to-background ratio and allow for a mobile detector operation under many environmental conditions including above ground and close to reactor sites. The neutrino detector can be used, for instance, for reactor operation monitoring, geological-radiochemical surveys and neutrino telecommunication systems.

IPC Classes  ?

• G01T 1/00 - Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
• G01V 5/06 - Prospecting or detecting by the use of ionising radiation, e.g. of natural or induced radioactivity specially adapted for well-logging for detecting naturally radioactive minerals

Abstract

A magnetic confinement apparatus (100) comprises an evacuable vessel (10) having a torus shape with an inner torus hole (11) and being configured for accommodating a fusion plasma (1), a magnetic coil device (20) being configured for creating a magnetic confinement field (2) in the vessel (10), wherein the magnetic coil device (20) comprises a plurality of axisymmetric coils (21) being configured for creating the magnetic confinement field (2) with an axisymmetric field equilibrium, and a control device (30) being configured for controlling the magnetic coil device (20), wherein the magnetic coil device (20) further comprises at least two quasi-axisymmetric perturbation (QAP) coils (22) being placed outside the vessel (10) within the torus hole (11) of the torus shape and being arranged for subjecting the axisymmetric field equilibrium of the magnetic confinement field (2) to quasisymmetry-preserving perturbations, so that the magnetic confinement field (2) created by the magnetic coil device (20) has quasi-axisymmetry and a magnetic equilibrium of the magnetic confinement field has a quasi-axisymmetric stellarator configuration of the magnetic confinement apparatus (100). Furthermore, a fusion reactor apparatus (200), including the magnetic confinement apparatus (100) and a method of operating the magnetic confinement apparatus are disclosed.

IPC Classes  ?

• G21B 1/05 - Thermonuclear fusion reactors with magnetic or electric plasma confinement
• G21B 1/11 - Thermonuclear fusion reactors Details

Abstract

In a method of determining an arrangement of point sources in a sample the point sources are scanned (3) with a probe signal comprising a probe signal intensity. A spatial intensity distribution of the probe signal intensity has a local probe signal intensity minimum that is, in at least one spatial direction, delimited on both sides by probe signal intensity maxima. The local probe signal intensity minimum is positioned at different probe signal minimum positions at distances in the at least one spatial direction. A measurement intensity of a measurement signal coming from the point sources is registered (4) for each of the different probe signal minimum positions. The measurement intensity depends on the probe signal intensity at point source positions of the point sources. The point sources are limited (2) both to a point source number of at least 2, and to such a small spatial area of the sample that a spatial course of the registered measurement intensities over the different probe signal minimum positions has one local measurement signal minimum only. The arrangement of the point sources is determined (5) from the spatial course of the registered measurement intensities over the different probe signal minimum positions utilizing previous knowledge of the arrangement of the point sources.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G01N 21/64 - FluorescencePhosphorescence

Abstract

The present invention relates to a method for producing aliphatic aldehydes from syngas, a ruthenium catalyst being used in the process.

IPC Classes  ?

• C07C 45/49 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reaction with carbon monoxide
• B01J 23/46 - Ruthenium, rhodium, osmium or iridium
• B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes

Abstract

The present invention relates to the use of the compound of the formula (I) and the composition thereof as control agent for plant diseases caused by fungi, oomycetes and bacteria. Plant pathogens produce self-aggregating proteins, like beta-amyloid proteins, that can be important parts of extracellular structures, for example cell walls, adhesion structures to biological surfaces and other pathogenicity related infection structures. This invention discloses that the compound of the formula (I) interferes with the aggregation of such proteins and thus reduce plant pathogen growth significantly. The present invention relates to the use of the compound of the formula (I) and the composition thereof as control agent for plant diseases caused by fungi, oomycetes and bacteria. Plant pathogens produce self-aggregating proteins, like beta-amyloid proteins, that can be important parts of extracellular structures, for example cell walls, adhesion structures to biological surfaces and other pathogenicity related infection structures. This invention discloses that the compound of the formula (I) interferes with the aggregation of such proteins and thus reduce plant pathogen growth significantly.

IPC Classes  ?

• A01N 43/82 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with three hetero atoms
• A01N 43/50 - 1,3-DiazolesHydrogenated 1,3-diazoles
• A01N 43/56 - 1,2-DiazolesHydrogenated 1,2-diazoles
• A01N 43/80 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
• A01N 43/84 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
• A01P 3/00 - Fungicides
• C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 233/64 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
• C07D 249/08 - 1,2,4-TriazolesHydrogenated 1,2,4-triazoles
• C07D 261/08 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 271/107 - 1,3,4-OxadiazolesHydrogenated 1,3,4-oxadiazoles with two aryl or substituted aryl radicals attached in positions 2 and 5
• C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 413/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

The present solution relates to animal behaviour modulation of at least one first animal to be carried out on a device attached to a second animal. The device comprises a memory, at least one sensor, a processor, and a signal generator. The method comprises: storing, in the memory, at least one extracted characteristic feature of training data of at least one monitored physical quantity in at least one degree of freedom in momentum, specific to at least one behaviour of the second animal and/or at least one local environmental condition related to the second animal; monitoring, by the at least one sensor, the at least one monitored physical quantity of the second animal and/or the at least one local environmental condition related to the second animal; determining, by the processor, a type of behaviour of the second animal; and generating, by the signal generator, a warning signal.

IPC Classes  ?

• A01K 27/00 - Leads or collars, e.g. for dogs
• A01K 11/00 - Marking of animals
• A01M 29/16 - Scaring or repelling devices, e.g. bird-scaring apparatus using sound waves

Abstract

The invention relates to a method of running a laser system (10) for providing a laser beam (20) capable of heating and/or evaporating and/or sublimating a target (120) located in a reaction chamber (110) of an evaporation system (100), the laser system (10) comprising a laser light source (12) for providing a laser beam (20), and beam adjusting means (40) for adjusting at least the cross section (22) of the laser beam (20), the beam adjusting means (40) comprising along the laser beam (20) a first adjusting section (42), a clipping aperture (70) with a clipping opening (72) and a second adjusting section (44). Further, the invention relates to a laser system (10) for heating and/or evaporating and/or sublimating a target (120) located in a reaction chamber (110) of an evaporation system (100), the laser system (10) comprising a laser light source (12) for providing a laser beam (20), wherein the laser system (10) comprises beam adjusting means (40) comprising along the laser beam (20) a first adjusting section (42), a clipping aperture (70) with a clipping opening (72) and a second adjusting section (44). Additionally, the invention relates to an evaporation system (100) for coating a substrate (126) with evaporated and/or sublimated material of a source (124), comprising a reaction chamber (110) with a reaction volume (112) for arranging the source (124) and the substrate (126), and a substrate (126) laser system (10) for heating the substrate (126) and/or a source (124) laser system (10) for evaporating and/or sublimating material of the source (124).

IPC Classes  ?

• B23K 26/352 - Working by laser beam, e.g. welding, cutting or boring for surface treatment
• B23K 26/06 - Shaping the laser beam, e.g. by masks or multi-focusing
• B23K 26/40 - Removing material taking account of the properties of the material involved
• B23K 26/70 - Auxiliary operations or equipment

Abstract

A sample receptacle apparatus (100) for arranging a fluid sample (1) in a beam path (2) of measuring radiation (3) in a gas-tight measuring apparatus (200), comprises a sample cell (10) having plane, plate-shaped cell windows (11) with a spacing therebetween, wherein the sample cell (10) is configured for accommodating the sample (1) in the spacing between the cell windows (11), and a cell holder device (20) having a cell support body (21), a first coupling section (22) and a second coupling section (23), wherein the cell support body (21) is configured for accommodating the sample cell (10) and for setting a temperature of the sample cell (10), the first and second coupling sections (22), (23) are configured for a gas-tight coupling of the cell holder device (20) with a closed container device (240) of the measuring apparatus (200), and the cell holder device (20) provides a beam passage (4) along a longitudinal direction z through the first coupling section (22), the cell support body (21) with the sample cell (10), and the second coupling section (23), wherein the sample cell (10) is arranged in the beam passage (4) such that a normal of at least one of the cell windows (11) deviates from the longitudinal direction z of the beam passage (4). Furthermore, a measuring apparatus for a spectroscopic investigation of a sample, including the sample receptacle apparatus (100) and a spectroscopic measuring method are described.

IPC Classes  ?

• G01N 21/03 - Cuvette constructions
• G01N 21/05 - Flow-through cuvettes
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
• G01N 21/21 - Polarisation-affecting properties
• G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
• G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
• G01N 21/3581 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation
• G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
• G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light

Abstract

A method of optical and nucleic acid barcoding of material, the method comprising: providing a first nucleic acid barcode identifiable by sequencing means; providing an optical barcode identifiable by optical means and comprising a second nucleic acid barcode identifiable by said sequencing means; providing material from which nucleic acid molecules are derivable; partitioning the first nucleic acid barcode, the optical barcode and the material within a partition; wherein the material within the partition can be uniquely identified by said optical means using the optical barcode; wherein the first nucleic acid barcode is configured to separately combine with nucleic acid molecules derived from the material and with the second nucleic acid barcode, such that both the nucleic acid molecules derived from the material and the optical barcode encapsulated with the material within the partition can be uniquely identified by said sequencing means using the first nucleic acid barcode, such that the nucleic acid molecules derived from the material identified by said sequencing means can be associated with the material identified by said optical means.

IPC Classes  ?

• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

The present invention relates to inhibitors of cyclin-dependent kinase 7 (CDK7) and their uses in the treatment of viral infections, in particular infections by DNA-viruses, such as Herpesviridae or Papillomaviridae. The present invention also relates to methods of treatment of viral infections using such inhibitors of cyclin-dependent kinase 7.

IPC Classes  ?

• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 31/20 - Antivirals for DNA viruses

Abstract

In a first aspect, the present invention relates to a method of imaging and screening of a compound of interest in a sample based on different types of imaging. Namely, the method comprise first acquiring low or high magnification images of the sample and, after determining a region of interest, superresolution microscopy of the region of interest to screen the compound of interest. In addition, a system for imaging and screening a compound of interest in a sample is described, said system comprising a microscope system combining diffraction limited imaging techniques with superresolution techniques. The system optionally includes a database of properties of known compounds. Finally, a computer program product is provided residing on a computer readable medium, allowing performing the method according to the present invention for controlling a microscope system.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence

Abstract

Provided is a computer-implemented method for analyzing experimental data. The method comprises receiving a first data set including the experimental data to be analyzed. The method further comprises receiving one or more variation data sets, wherein each variation data set comprises information regarding a variation of experimental observations. Moreover, the method comprises extrapolating the experimental data by applying a variation to the experimental data, wherein the applied variation corresponds to the one or more variations of the experimental observations specified by the information comprised in the one or more variation data sets. The method further comprises generating a synthetic data set based on the extrapolated experimental data, analyzing the synthetic data set, and providing an output based on a result of the analysis of the synthetic data set. The received one or more variation data sets are selected depending on one or more types of noise related to the experimental data to be analyzed.

IPC Classes  ?

• G16B 40/20 - Supervised data analysis
• G16B 40/30 - Unsupervised data analysis

Abstract

The present invention pertains to the fields of antibody technology, biochemistry, medicine, pharmacology, infection biology, and anti-viral therapy. More specifically, it discloses antibodies, particularly single-domain antibodies, e.g., VHH antibodies that bind an assembled HIV-1 capsid such that the capsid is prevented from entering the permeability barrier of nuclear pore complexes, also called the FG phase. Through the effects of these antibodies, HIV-1 is effectively prevented from entering the cell's nucleus and thus blocked in its life cycle.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

An interferometric scattering microscopy (iSCAT) apparatus (100) for iSCAT-based imaging a sample under investigation, for obtaining a sample image, comprises an optical imaging system with an illumination device (10), an optical relaying device (20) including a beam splitting device (21), a sample receptacle (30) and a detector device (40). The illumination device (10) includes a laser source device (11) being arranged for creating illumination light (2). The optical relaying device (20) is arranged between the laser device (11) and the sample receptacle (30) for relaying the illumination light (2) to the sample receptacle (30). The beam splitting device (21) is arranged for deflecting a first portion (2A) of the illumination light (2) towards the sample receptacle (30), deflecting a second portion (2B) of the illumination light (2) towards the detector device (40) and for superimposing scattering light (2C) scattered at a sample (1) arranged at the sample receptacle (30) with the second portion (2B) of the illumination light (2). The detector device (40) is arranged for receiving the superimposed scattering light (2C) and second portion (2B) of the illumination light (2) in an image plane of the optical imaging system. A coherence setting device (50) is arranged for targeted setting a point spread function of the optical imaging system in the image plane by applying and controlling a spatial degree of coherence of the illumination light (2) output by the laser source device (11). Furthermore, a method of iSCAT microscopy, including iSCAT-based imaging a sample (1), in particular including bioparticles, like protein particles and/or protein molecules, is described, wherein the iSCAT apparatus (100) is employed.

IPC Classes  ?

• G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials
• G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
• G01N 21/47 - Scattering, i.e. diffuse reflection
• G01N 15/1433 - Signal processing using image recognition
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G02B 21/00 - Microscopes
• G01N 15/10 - Investigating individual particles
• G01N 15/1434 - Optical arrangements

Abstract

In a first aspect, the invention relates to a method for imaging and screening a component of interest in a sample based on different types of imaging. In particular, the method comprises first acquiring low or high magnification images of the sample and, after determining the region of interest, MINFLUX and/or MINSTED superresolution microscopy of the region of interest to screen the compound of interest. A system is further described for imaging and screening a compound of interest in a sample, the system comprising a microscope system combining diffraction-limited imaging techniques with at least one of MINFLUX or MINSTED superresolution techniques. The system optionally comprises a database of properties of known compounds. Finally, a computer program product resided on a computer-readable medium is provided to enable the method of the invention to be carried out for controlling a microscope system.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: as well as to the corresponding photoactivated fluorescent dyes having the structural formula II: The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: as well as to the corresponding photoactivated fluorescent dyes having the structural formula II: The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: as well as to the corresponding photoactivated fluorescent dyes having the structural formula II: The invention further relates to the use of the photoactivatable compounds as such or after photoactivation, in particular as fluorescent tags, analytical reagents and labels in optical microscopy, imaging techniques, protein tracking, nucleic acid labeling, glycan analysis, capillary electrophoresis, flow cytometry or as a component of biosensors, or as analytical tools or reporters in microfluidic devices or nanofluidic circuitry.

IPC Classes  ?

• C09B 57/00 - Other synthetic dyes of known constitution
• C09B 6/00 - Anthracene dyes not provided for above
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

The present invention relates to a method for producing a fat composition comprising the following steps: a) providing water, b) adding lipase, c) adding triglyceride, d) incubate the mixture obtained in step c), e) inactivation of lipase, f) separation of the aqueous phase from the fatty phase of the mixture obtained in step e) in a separating funnel, g) optional heating of the separated fatty phase to remove the remaining aqueous phase, wherein the method is performed without the addition of papain. In addition, the present invention relates to a fat composition obtained by the method according to the invention and a food composition comprising the fat composition according to the invention, as well as method for producing the food composition.

IPC Classes  ?

• A23L 13/60 - Comminuted or emulsified meat products, e.g. sausagesReformed meat from comminuted meat product
• A23L 33/115 - Fatty acids or derivatives thereofFats or oils
• C11B 1/00 - Production of fats or fatty oils from raw materials
• C11C 3/10 - Ester interchange
• C12P 7/64 - FatsFatty oilsEster-type waxesHigher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl groupOxidised oils or fats

Abstract

The invention discloses a method that uses a measured density map of a molecule and related molecular model to improve the resolution of the molecule structure using fitness scores between conformers of models of the unresolved parts of the molecule and the density map.

IPC Classes  ?

• G16B 15/00 - ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR

Abstract

The present invention relates to methods for modifying the activity of transcription factors by altering the periodicity and/or number of the aromatic amino acid residues in their intrinsically disordered regions (IDRs) thereby obtaining altered transcription factors having modified, e.g., increased and/or reduced transcriptional activity. Further, the present invention relates to novel altered transcription factors and nucleic acid molecules encoding those altered transcription factors. Furthermore, applications for the altered transcription factors, e.g., in cell programming methods, are disclosed.

IPC Classes  ?

• C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 38/00 - Medicinal preparations containing peptides
• C12N 15/79 - Vectors or expression systems specially adapted for eukaryotic hosts

Abstract

The present invention relates to a method for increasing the photosynthesis of a plant, plant part, or plant cell by increasing the expression of the squamosa promoter binding protein-like gene 9 (SPL9 gene) in the plant, plant part, or plant cell and/or by increasing the level of the squamosa promoter binding protein-like protein 9 (SPL9 protein) in the plant, plant part, or plant cell.

IPC Classes  ?

• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• C12N 9/22 - Ribonucleases
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

A potential measuring apparatus (100) for determining a physicochemical surface property based on a surface potential at a sample surface (2) of a solid sample (1), like the surface potential and/or a zeta potential of the sample surface (2), comprises a sample support (10) for accommodating the sample (1), a drop supply device (20) for placing a liquid probe drop (3) on the sample surface (2), a drop movement device (30) for providing a sliding movement of the probe drop (3) along a predetermined sliding path (4) on the sample surface (2), an electrode measuring device (40) for sensing an electrical quantity including at least one of a drop voltage and a drop charge of the probe drop (3) after passing the sliding path (4), wherein the electrode measuring device (40) includes a probe electrode (41) arranged at a downstream end of the sliding path 4 and a measuring circuit (42) coupled with the probe electrode (41), and a calculation device (50) for determining the physicochemical surface property based on the electrical quantity. Furthermore, a potential measuring method for determining a physicochemical surface property based on a surface potential at a sample surface (2) of a solid sample (1) is described.

IPC Classes  ?

• G01N 13/02 - Investigating surface tension of liquids
• G01N 27/60 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrostatic variables
• G01R 31/26 - Testing of individual semiconductor devices

Abstract

Method for automatic focusing and astigmatism correction for a specific microscope setup, in particular an electron microscope, the microscope being at least adjustable in microscope parameters a working distance, a stigmator in a x-direction and a stigmator in a y-direction, the method comprising the steps: a) capturing a first image of a sample with a first working distance perturbation and capturing a second image of the sample with a second working distance perturbation around a current working distance and current stigmator settings; b) selecting n subareas of the first image and n subareas of the second image, n≥1, wherein an i-th subarea of the first image and an i-th subarea of the second image form an i-th input patch pair, 1≤i≤n; c) processing each i-th input patch pair and receiving an i-th correction term comprising a correction to the current working distance, stigmator in x-direction and stigmator in y-direction; d) receiving an output correction term as a function of all the correction terms; e) adjusting the current working distance and stigmator settings by applying the output correction term to the current working distance and stigmator settings.

IPC Classes  ?

• H01J 37/21 - Means for adjusting the focus
• H01J 37/153 - Electron-optical or ion-optical arrangements for the correction of image defects, e.g. stigmators

Abstract

Provided are a method and a device for characterizing a resonator element, a method and a device for providing an optical frequency reference, a LIDAR system and a gas sensing system. The method includes coupling a laser light into the resonator element, the resonator element having multiple carrier resonances for the carrier frequency of the laser light.

IPC Classes  ?

• G01M 11/02 - Testing optical properties

Abstract

The invention relates to a source arrangement (10) for a TLE system (100) for providing a source element (12) comprising or consisting of a source material (14) to be evaporated and/or sublimated by a laser beam (112), comprising a support (20) carrying said source element. Further, the invention relates to a TLE system (100) comprising a laser source (110) for providing a laser beam (112), a reaction chamber (120) for containing a reaction atmosphere (124), a source arrangement (10) for providing a source element (12) comprising or consisting of a source material (14) to be evaporated and/or sublimated by the laser beam (112) within the reaction chamber (120), and a substrate arrangement (130) for providing a substrate (132) to be coated within the reaction chamber (120) with the evaporated and/or sublimated source material (14). In addition, the invention relates to a method for using a TLE system (100), the TLE system (100) comprising a laser source (110) for providing a laser beam (112), a reaction chamber (120) for containing a reaction atmosphere (124), a source arrangement (10) for providing a source element (12) comprising or consisting of a source material (14) to be evaporated and/or sublimated by the laser beam (112) within the reaction chamber (120), and a substrate arrangement (130) for providing a substrate (132) to be coated within the reaction chamber (120) with the evaporated and/or sublimated source material (14).

IPC Classes  ?

• C23C 14/28 - Vacuum evaporation by wave energy or particle radiation

Abstract

The present disclosure relates to compounds that bind to the kelch domain-containing protein 2 (KLHDC2) E3 ligase active site and heterobifunctional targeted protein degraders comprising the compounds. Methods of using these degraders in the treatment of cancer is also described. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

IPC Classes  ?

• C07D 495/14 - Ortho-condensed systems
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• C07D 471/04 - Ortho-condensed systems
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

Connectomes of human cortical gray matter require high-contrast homogeneously stained samples sized at least 2-3 mm on a side, and a whole-mouse brain connectome requires samples sized at least 5-10 mm on a side. Here, en-bloc staining and postprocessing protocols are reported, including dehydrating and embedding of neuronal samples, for dense neuronal circuit reconstruction and other applications.

IPC Classes  ?

• G01N 1/30 - StainingImpregnating
• G01N 23/2251 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material using electron or ion microprobes using incident electron beams, e.g. scanning electron microscopy [SEM]

Abstract

The present invention relates to multifunctional agents as defined in the claims based on N-substituted 1,4-benzothiazepines with cyclopropanol groups and their "open" analogues (such as the 3-[(4-methoxyphenyl)oxy]- and 3-[(4-5 methoxyphenyl)thio]propane-1-amine cyclopropanol derivatives; see formulae below) as well as the rearrangement products obtained from such cyclopropanol compounds, i.e. ethyl ketones, and the oxidation products from such cyclopropanol compounds, i.e. oxiranes. Such compounds can be used by preventing Ca2+ leak through ryanodine receptor 2 (RyR2) and enhance cardiac sarco-endoplasmic reticulum (SR) Ca2+ load by activation of Ca2+-dependent ATPase 2a (SERCA2a) for example for the treatment of cardiac or neuronal diseases.

IPC Classes  ?

• A61P 1/18 - Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
• A61P 9/04 - Inotropic agents, i.e. stimulants of cardiac contractionDrugs for heart failure
• A61P 9/06 - Antiarrhythmics
• A61P 25/00 - Drugs for disorders of the nervous system
• C07C 213/08 - Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
• C07C 217/20 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
• C07C 319/20 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
• C07C 323/25 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
• C07D 281/10 - Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Abstract

The present invention relates to a process for preparing diamond particles, comprising subjecting a nanodiamond precursor material to a pressure of at least 8 GPa and a temperature of at least 900°C, wherein the diamond precursor material comprises a polycyclic aromatic compound which contains from 10 to 200 fused six-membered aromatic rings.

IPC Classes  ?

• C01B 32/26 - Preparation
• B01J 3/06 - Processes using ultra-high pressure, e.g. for the formation of diamondsApparatus therefor, e.g. moulds or dies

Abstract

The present invention relates to an underwater apparatus for sampling and to a related method for sampling in situ water flows in a body of water.

IPC Classes  ?

• G01N 1/14 - Suction devices, e.g. pumpsEjector devices
• G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state

Abstract

The present invention relates to nucleic acids providing new-to-nature target sites for site-directed nucleases (landing pads) and methods to generate and use the same. Furthermore, the elements for generating said nucleic acids, namely underrepresented sequences/sequence fragments in one or more reference genome and protospacers are provided as well as methods to generate said elements. The invention also provides genomes and cells comprising the nucleic acids (landing pads).

IPC Classes  ?

• C12N 15/01 - Preparation of mutants without inserting foreign genetic material thereinScreening processes therefor
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention relates to proteins or polypeptides involved in fatty acid synthesis, such as fatty acid synthase (FAS). Said protein comprises one or more polypeptide chains wherein said polypeptide chains comprises one or more subunits having at least one amino acid substitution as defined resulting in altered activity of fatty acid synthesis. The present invention relates further to nucleic acid molecules encoding the proteins or the polypeptide domains as well to host cells containing said nucleic acid molecules, e.g. in form of vectors. The present invention describes further a method for production of fatty acids comprising the cultivation of the host cells according to the present invention as well as the use of the protein according to the present invention or the nucleic acid according to the present invention or the host cell according to the present invention for the production of biofuels, the production of fine chemicals, flavoring compounds, the determination of fungicides and actinobacterial biocides. Moreover, in silico methods are described allowing the identification of molecules capable of selectively altering the activity of an enzymatic domain present in the FAS or altering a step of fatty acid synthesis by FAS I comprising determining and modelling molecules interacting under physiological conditions with at least one amino acid in a protein as defined herein. Further, a method of identifying a compound capable of altering at least one of the enzymatic activities of FAS is provided including the step of bringing into contact a candidate compound with the FAS as defined herein and determining whether said candidate demonstrates any interaction with the FAS. Finally, a protein is provided, namely, a mutated ACP which results in alteration of FAS activity.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12P 7/6409 - Fatty acids
• C12P 7/6463 - Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil

Abstract

The present invention relates to method of treating a patient suffering from a gastrointestinal stromal tumor (GIST), comprising administering to said patient a pharmaceutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof. Furthermore, the present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in the treatment of a gastrointestinal stromal tumor (GIST) in a patient.

IPC Classes  ?

• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
• A61K 31/4462 - Non-condensed piperidines, e.g. piperocaine only substituted in position 3
• A61K 31/4965 - Non-condensed pyrazines
• A61K 31/5375 - 1,4-Oxazines, e.g. morpholine
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a method for expanding liver cells, wherein the method comprises (a) expanding the liver cells within an extracellular matrix in an expansion medium, wherein the expansion medium comprises a Wnt surrogate or activator and an inhibitor of the Hippo signalling pathway, and preferably with the proviso that the expansion medium does not comprise nicotinamide.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 35/407 - LiverHepatocytes

Abstract

The present invention relates to a method for releasing macromolecules from one or more living cells comprising (a) flattening the one or more living cells between two surfaces such that the membrane of the living cells becomes permeable or becomes more permeable for the macromolecules, wherein the surfaces that face the cells are functionalized by an antifouling coating that comprises biocompatible polymeric brushes, and (b) incubating the one or more fattened cells, wherein the macromolecules are released from the one or more living cells.

IPC Classes  ?

• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means

Abstract

The present invention relates to a method for the introduction of macromolecules and/or particles into living cells comprising (a) flattening the living cells between two surfaces such that the cells become amenable for the uptake of the macromolecules and/or particles, wherein the surfaces that face the cells are functionalized by an antifouling coating that comprises biocompatible polymeric brushes, and (b) incubating the fattened cells, wherein the macromolecules and/or particles become introduced into the cells.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/33 - Disintegrators
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave

Abstract

The present application relates to: an imaging device for telecentric imaging of a plurality of light beams into a target area; and an associated micromirror device. The imaging device comprises a beam tilt correction element and a beam control device which is designed to image N >= 2 substantially non-overlapping light beams onto the beam tilt correction element and to control a position of one or more of the N light beams on the beam tilt correction element. The imaging device also comprises a beam imaging device which is designed to image the light beams corrected by the beam tilt correction element onto the target area, wherein the beam tilt correction element is designed to correct a tilt of each of the N light beams such that the N light beams are imaged onto substantially non-overlapping positions in the target area. The beam tilt correction element may be implemented, for example, using a micromirror device.

IPC Classes  ?

• G02B 27/10 - Beam splitting or combining systems
• G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
• G02B 5/09 - Multifaceted or polygonal mirrors
• G02B 26/12 - Scanning systems using multifaceted mirrors

Abstract

The present invention relates to a method for flattening living cells, comprising (a) flattening the cells between two microscopy slides, wherein the surfaces of the microscopy slides that face the cells are functionalized by an antifouling coating that comprises biocompatible polymeric brushes.

IPC Classes  ?

• G01N 1/30 - StainingImpregnating
• G06T 7/00 - Image analysis
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present invention relates to CoA-independent reductive aldolases derived from ene reductases (ERs) for preparing α-branched β'-hydroxy carbonyl compounds through enzymatic-catalyzed reductive aldol reaction by reacting α,β-unsaturated carbonyl donors with carbonyl acceptors in the presence of a polypeptide capable of catalyzing reductive CoA-independent aldol reactions and a cofactor, wherein the polypeptide is a modified ene reductase (ER). The present invention further relates to a method for preparing α-branched β'-hydroxy carbonyl compounds through enzymatic-catalyzed reductive aldol reaction.

IPC Classes  ?

• C12P 7/02 - Preparation of oxygen-containing organic compounds containing a hydroxy group

Abstract

The present invention relates to compounds, compositions and kits suitable to precise genome editing efficiency in a eukaryotic target organism.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Abstract

The current disclosure relates to methods for treating ovarian cancer based on specific antigen expression of the cancer. Furthermore, the expressed antigen may be used in immunotherapeutic methods for treatment of the ovarian cancer. Aspects of the disclosure relate to immunotherapies targeting CT45 polypeptides, methods for treating ovarian cancer based on CT45 expression, and kits for detecting CT45 polypeptides and nucleotides.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
• A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61K 33/243 - PlatinumCompounds thereof
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 38/20 - Interleukins
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61K 40/42 - Cancer antigens
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• C07K 14/725 - T-cell receptors
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present invention relates to a polypeptide with at least 85% sequence identity to SEQ ID NO: 1, as an endo-β-1,4-xylanase (EC 3.2.1.8) having transglycosylation activity. Preferably, said polypeptide is obtained from Rhamnusium bicolor. In another aspect, the present invention refers to a polynucleotide encoding said polypeptide, a preparation method of said polypeptide, use of said polypeptide for producing xylose oligosaccharides by transglycosylation reaction, and a producing method of xylose oligosaccharides by using said polypeptide. Furthermore, the present invention is directed to a mixture of xylose oligosaccharides obtainable by the producing method by using said polypeptide, and use of the mixture of said xylose oligosaccharides in life science, in particular, as prebiotics, nutraceuticals, pharmaceutically active ingredients, or food supplements.

IPC Classes  ?

• C12P 19/04 - Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
• C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)
• C12P 19/02 - Monosaccharides

Abstract

The present invention relates to a catalytically active material, the preparation thereof, and the use of the catalytically active material, e.g. in the catalytic hydrogenation of CO2 to methanol. The catalytically active material comprising a metal oxide doped with a doping metal, wherein the metal oxide is selected from CeO2, ZnO, Ga2O3, In2O3, ZrO2, Fe2O3 and Al2O3, the doping metal is selected from Cu, Rd and Au, and the catalytically active material is obtainable by a method comprising a step of non-thermal plasma treatment.

IPC Classes  ?

• B01J 23/89 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with noble metals
• B01J 35/45 - Nanoparticles
• B01J 35/58 - Fabrics or filaments
• B01J 37/03 - PrecipitationCo-precipitation
• B01J 37/08 - Heat treatment
• B01J 37/12 - Oxidising
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• C07C 1/12 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of carbon from carbon dioxide with hydrogen

Goods & Services

Education, providing of training, cultural activities. Research services.

Abstract

The invention relates to nanofilament-coated membranes with hierarchical porous structures comprising a microporous polymer support membrane having through-going pores with a nominal pore diameter in the range from 0.2 μm to 50 μm and a superhydrophobic fluorine-free nanoporous layer having through-going pores with a nominal pore diameter in the range from 5 nm to 200 nm provided on said support membrane and comprising or consisting of a porous network of polysiloxane nanofilaments. In more specific embodiments of said nanofilament-coated porous membranes, the microporous support membrane comprises or consists of a polymer which is selected from the group consisting of polyethersulfone (PES), cellulose acetate (CA), polypropylene (PP), polyamide (nylon), polytetrafluoroethylene (PTFE), polyvinyl difluoride (PVDF) or polyethylene (PE). A second aspect of the invention relates to the use of these nanofilament-coated porous membranes for membrane distillation, in particular in a process of desalination of saline or distillation of contaminated water or extraction of water from waste water or extraction of other volatile components from a feed solution and to a device, in particular a membrane distillation device, comprising these nanofilament-coated porous membranes. A further aspect of the invention relates to a method for preparing these nanofilament-coated porous membranes.

IPC Classes  ?

• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 61/36 - PervaporationMembrane distillationLiquid permeation
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 69/10 - Supported membranesMembrane supports
• B01D 71/70 - Polymers having silicon in the main chain, with or without sulfur, nitrogen, oxygen or carbon only
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis

Abstract

The present invention refers to a coating apparatus for coating a substrate of a substrate material with at least one material layer of a layer material, said coating apparatus comprising a process chamber having a process volume for receiving a substrate holder for arranging the substrate, wherein the substrate holder is arranged in a fixed position in the process volume such that the substrate holder can furthermore be provided rotatable and/or movable essentially in a plane normal to the deposition direction as a whole, wherein the process chamber has a chamber wall for at least substantially completely enclosing the process volume; a gas system connected in a fluid-communicating manner to the process volume for generating a coating atmosphere in the process volume; and a source holder arranged in the process volume and providing at least one source material.

IPC Classes  ?

• C23C 16/48 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating by irradiation, e.g. photolysis, radiolysis, particle radiation
• C23C 16/40 - Oxides
• C23C 16/458 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for supporting substrates in the reaction chamber

Abstract

A method of determining a dimensional parameter of a microstructured optical fiber (MOF), the method comprising: directing radiation towards the MOF; obtaining one or more signals associated with interference of the radiation between structural elements of the MOF; determining a distance between the structural elements based on the one or more signals associated with interference of the radiation between structural elements of the MOF; and determining the dimensional parameter based on the determined distance. A method for obtaining a MOF is also described.

IPC Classes  ?

• G02B 6/02 - Optical fibres with cladding
• G02B 6/032 - Optical fibres with cladding with non-solid core or cladding

Abstract

The invention relates to a method for the controlled deposition of a nitride layer (80) of a target nitride (82) on a substrate (70) in a thermal laser epitaxy (TLE) system (100), the target nitride (82) comprising a defined stoichiometry and being formed from one or more evaporated and/or sublimated source materials and nitrogen originating from a gaseous nitridizing agent (54), the TLE system (100) further comprising a reaction chamber (10) and one or more laser sources (20) for providing laser beams (22) within the reaction chamber (10). Further, the invention relates to a TLE system (100) constructed for carrying out said method.

IPC Classes  ?

• C23C 14/00 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
• C23C 14/06 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
• C23C 14/28 - Vacuum evaporation by wave energy or particle radiation
• C23C 14/54 - Controlling or regulating the coating process
• C30B 23/06 - Heating of the deposition chamber, the substrate, or the materials to be evaporated
• C30B 29/40 - AIIIBV compounds

Abstract

The present invention relates to an Poly(ADP-Ribose) Polymerase 1 (PARP-1) inhibitor and/or an immune checkpoint inhibitor for the treatment of cancer in a subject that overexpresses Ubiquilin 1 (UBQLN1) and/or Ubiquilin 4 (UBQLN4) as well as a method for determining whether a cancer subject is amenable for the treatment with a PARP-1 inhibitor and/or an immune checkpoint inhibitor based on the detection of the mRNA and/or protein expression level of UBQLN1 and/or UBQLN4 in a sample obtained from said cancer subject.

IPC Classes  ?

• A61K 31/502 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present disclosure relates to trapping and manipulating of neutral atoms in optical trapping potentials. In one aspect, an apparatus comprises a trapping laser system and optics for generating an optical trapping lattice at a trapping volume inside a vacuum chamber, wherein the optics for generating the optical trapping lattice are configured to generate, based on the output of the trapping laser system, a single elliptical trapping laser beam that is retroreflected and focused, using a bow-tie configuration, to the trapping volume to generate the optical trapping lattice.

IPC Classes  ?

• G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating

Abstract

The present disclosure relates to trapping and manipulating neutral atoms for quantum computing, quantum simulation and metrology. In one aspect a method comprises loading a plurality of neutral atoms into a loading trap array arranged adjacent to or at least partially collocated with a storage trap array, selectively removing neutral atoms in a first electronic state |1> from the storage trap array, determining a trap occupancy of neutral atoms in the storage trap array in a second electronic state |2>, and of neutral atoms in the loading trap array, and moving, based on the determined trap occupancy of the neutral atoms in the storage trap array and in the loading trap array, neutral atoms from the loading trap array to one or more non-occupied trapping sites of the storage trap array. The method may further comprise shelving the neutral atoms in a shelving state.

IPC Classes  ?

• G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating

Abstract

The present invention relates to a catalytically active material, the preparation thereof, and the use of the catalytically active material, e.g. in the catalytic oxidation of CO to CO2 or in the catalytic hydrogenation of alkyne. The catalytically active material comprises a support5 comprising a metal oxide, and atomically dispersed noble metal on the surface of the support, wherein the metal oxide is selected from TiO2, CeO2, ZnO, SnO2, Ga2O3, In2O3, ZrO2, and Fe2O3, the noble metal is selected from Pt, Pd, Rh, and Au, and the catalytically active material is obtainable by a method comprising a step of non-thermal plasma treatment in the presence of O2.

IPC Classes  ?

• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• B01J 23/63 - Platinum group metals with rare earths or actinides
• B01J 35/45 - Nanoparticles
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/03 - PrecipitationCo-precipitation
• B01J 37/08 - Heat treatment
• C01B 32/50 - Carbon dioxide
• C07C 5/08 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation of carbon-to-carbon triple bonds

Abstract

3113, and further selecting out of these compounds the ones which contain at least a heavy metal for high spin polarization, and sort these selected compounds with increasing spin-orbit-coupling (SOC), which results in a number of compounds which are sorted with increasing catalytic activity.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/089 - Alloys
• H01M 4/90 - Selection of catalytic material
• H01M 4/92 - Metals of platinum group

Abstract

The invention is related to a method of using a thermal laser evaporation (TLE) system (100), the system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source (30) comprising a source material (32), and a laser source (50) for providing laser radiation (52) at a surface (34) of the source (30) and thereby evaporating the source material (32). Further, the invention is related to a thermal laser evaporation system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source comprising a source material (32), and coupling means (12) provided by the reaction chamber (10) for coupling laser radiation (52) into the reaction chamber (10) for impinging on a surface (34) of the source (30) and thereby evaporating the source material (32).

IPC Classes  ?

• C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
• B23K 26/06 - Shaping the laser beam, e.g. by masks or multi-focusing
• B23K 26/073 - Shaping the laser spot
• B23K 26/12 - Working by laser beam, e.g. welding, cutting or boring in a special environment or atmosphere, e.g. in an enclosure
• B23K 26/362 - Laser etching

Abstract

The invention is related to a method of using a thermal laser evaporation (TLE) system (100), the system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source (30) comprising a source material (32), and a laser source (50) for providing laser radiation (52) at a surface (34) of the source (30) and thereby sublimating the source material (32). Further, the invention is related to a thermal laser evaporation system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source comprising a source material (32), and coupling means (12) provided by the reaction chamber (10) for coupling laser radiation (52) into the reaction chamber (10) for impinging on a surface (34) of the source (30) and thereby sublimating the source material (32).

IPC Classes  ?

• C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
• B23K 26/06 - Shaping the laser beam, e.g. by masks or multi-focusing
• B23K 26/064 - Shaping the laser beam, e.g. by masks or multi-focusing by means of optical elements, e.g. lenses, mirrors or prisms
• B23K 26/067 - Dividing the beam into multiple beams, e.g. multi-focusing
• B23K 26/073 - Shaping the laser spot
• B23K 26/08 - Devices involving relative movement between laser beam and workpiece
• B23K 26/12 - Working by laser beam, e.g. welding, cutting or boring in a special environment or atmosphere, e.g. in an enclosure
• B23K 26/362 - Laser etching

Abstract

The present invention relates to a method for the generation of outer radial glial (oRG) cells of the outer sub-ventricular (oSVZ)-like region in cerebral organoids comprising (a) culturing primate stem cells in a primate stem cell medium until about day 6, thereby inducing the formation of embryonic bodies; (b) culturing the embryonic bodies as obtained in step (a) in a neural induction medium until about day 11, thereby inducing the formation of organoids; wherein an inhibitor of TGF-β, an inhibitor of BMP and an inhibitor of WNT is present from about day 2 until about day 11; (c) embedding the organoids as obtained after steps (a) and (b) and if they display a size of at least 300 μm into a hydrogel that mimics the extracellular matrix (ECM), preferably Matrigel and culturing the organoids in a cerebral differentiation medium at least until about day 40, preferably at least until about day 60 and most preferably at least until about day 80, thereby obtaining cerebral organoids with oRG cells in oSVZ-like regions, wherein the organoids in step (c) are subjected to agitation from about day 15 onward, preferably by using an orbital shaker or a spinning bioreactor; and (d) optionally isolating one or more oRG cells from the oSVZ-like region.

IPC Classes  ?

• C12N 5/079 - Neural cells
• C12N 5/0793 - Neurons

Abstract

A method of scattering-type scanning near-field optical microscopy (s-SNOM) comprises placing an s-SNOM tip 11 at a near-field distance from a sample 1 and subjecting the s-SNOM tip 11 to a mechanical oscillation, which provides a primary modulation, illuminating the oscillating s-SNOM tip 11 with a sequence of illumination light pulses, wherein each of the illumination light pulses hits the s-SNOM tip 11 at a specific s-SNOM tip modulation phase φi of the mechanical oscillation, collecting scattering light pulse amplitudes Si, each being created by scattering one of the illumination light pulses at the s-SNOM tip 11, using a scattering light detector device 30, collecting the s-SNOM tip modulation phase i associated to each of the collected scattering light pulse amplitudes Si, using a mechanical oscillation detector device 40, and calculating an s-SNOM near-field signal by demodulating a scattering light function S(φi) of the scattering light pulse amplitudes Si in dependency on the s-SNOM tip modulation phases φi, wherein each of the s-SNOM tip modulation phases pi is obtained by splitting an output signal of the mechanical oscillation detector device 40 into a first output signal portion X and a second output signal portion Y being phaseshifted relative to the first output signal portion X and calculating the s-SNOM tip modulation phase φi of the primary modulation from the first and second output signal portions X, Y. Furthermore, a scanning near-field optical microscopy apparatus 100 is described.

IPC Classes  ?

• G01Q 60/18 - SNOM [Scanning Near-Field Optical Microscopy] or apparatus therefor, e.g. SNOM probes

Abstract

The present invention relates to a temperature control system (10) for adjusting a temperature (60) of a vacuum chamber (102), the temperature control system (10) comprising conduits (20) which can be thermally coupled to a chamber wall (110) of the vacuum chamber (102), a fluid pump (50), temperature adjusting means (30) comprising a heating means (32) or both a heating means (32) and a cooling means (34), and tubing (52) for fluidly connecting said conduits (20), fluid pump (50), and temperature adjusting means (30), respectively. Further, the present invention relates to a vacuum system (100) with a vacuum chamber (102), the vacuum chamber (102) comprising a chamber wall (110) enclosing a vacuum volume (106), a vacuum pump system (104) connected to the vacuum chamber (102) for evacuating the vacuum volume (106), and a temperature control system (10) for adjusting a temperature (60) of a vacuum chamber (102). In addition, the present invention relates to a method of adjusting the temperature (60) of a vacuum chamber (102) of said vacuum system (100).

IPC Classes  ?

• C23C 14/54 - Controlling or regulating the coating process
• C23C 14/28 - Vacuum evaporation by wave energy or particle radiation

Abstract

NicotianaNicotiana tabacum Nicotiana sylvestris Nicotiana sylvestris.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The present invention relates to a compound of general formula (I) The present invention relates to a compound of general formula (I) The present invention relates to a compound of general formula (I) or an enantiomer, diastereomer, stereoisomer, which mediates resistance against leaf- and planthopper pests. The present invention further relates to a method of producing the compound, an enzymatic production method the compound using at least a BBL2 polypeptide, as well as a PPO, AT1, ODC, HPL, PAL, C4H, 4CL, HCT and/or C3H activity. Further envisaged are genetically modified organisms producing the compound, expression cassettes for heterologous expression of the activities, the use of corresponding polypeptides and polynucleotides for the production of the compound, a composition including the compound, as well as uses of the compound for plant protection.

IPC Classes  ?

• C07C 235/78 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
• A01N 37/42 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing within the same carbon skeleton a carboxylic group or a thio-analogue, or a derivative thereof, and a carbon atom having only two bonds to hetero atoms with at the most one bond to halogen, e.g. keto-carboxylic acids
• A01P 15/00 - Biocides for specific purposes not provided for in groups
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 9/10 - Transferases (2.)
• C12N 9/88 - Lyases (4.)
• C12P 13/02 - Amides, e.g. chloramphenicol

Abstract

The present invention relates to a Janus kinase (JAK) inhibitor and to pharmaceutical composition comprising a Janus kinase (JAK) inhibitor, respectively, for use for the treatment of toxic epidermal necrolysis (TEN) and/or Stevens-Johnson-syndrome (SJS) and/or SJS/TEN overlap. The invention further relates to a method for treatment of toxic epidermal necrolysis (TEN) and/or Stevens-Johnson-syndrome (SJS) and/or SJS/TEN overlap comprising application of a Janus kinase (JAK) inhibitor to a patient.

IPC Classes  ?

• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 17/00 - Drugs for dermatological disorders
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

Disclosed is an optical fiber feedthrough (10) configured to feed through optical fibers (1) between an interior and exterior of evacuable vacuum chamber (30). The feedthrough includes at least one mounting flange (11a, 11b) configured for pressure-tight fastening to vacuum chamber and includes passage openings (12a, 12b) configured for pressure-tightly receiving a respective optical fiber. The passage openings are each provided with a sealing receptacle (13a, 13b) and a sealing element (14a, 14b) arranged therein for pressure-tightly receiving the respective optical fiber. A compression device (15a, 15b) is connected to each mounting flange, which is configured to compress the respective sealing elements axially along the respective passage openings. Also disclosed is an optical fiber assembly (20) including the feedthrough and optical fibers, and a method for passing a plurality of optical fibers between an interior and exterior of an evacuable vacuum chamber using the aforementioned feedthrough.

IPC Classes  ?

• G02B 6/44 - Mechanical structures for providing tensile strength and external protection for fibres, e.g. optical transmission cables

Abstract

Disclosed is a method of manufacturing an optical fiber, the method comprising: providing a fiber manufacturing intermediate product, the fiber manufacturing intermediate product comprising: (i) a hollow core cane comprising a first jacket with a hollow inner structure, wherein a plurality of capillaries are fused to the first jacket within the hollow inner structure; and (ii) a second jacket around the hollow core cane; roughening an outer surface of the second jacket over a portion (310) of the second jacket; coupling an end of the fiber manufacturing intermediate product to a pressure connector (402); and drawing a hollow core photonic crystal fiber from the fiber manufacturing intermediate product.

IPC Classes  ?

• C03B 37/027 - Fibres composed of different sorts of glass, e.g. fibre optics
• C03B 37/012 - Manufacture of preforms for drawing fibres or filaments

Abstract

An apparatus for determining an arrhythmia of a living heart comprises a signal evaluation device receiving a signal representing a present electric activity of the heart, and determining a frequency spectrum of the signal. The apparatus further comprises a pulse generator generating a sequence of electric pulses to be applied to the heart at a pulse repetition frequency that depends on the frequency spectrum and decreases by at least 20% over the sequence.

IPC Classes  ?

• A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
• A61N 1/37 - MonitoringProtecting
• A61N 1/39 - Heart defibrillators

Abstract

A method of manufacturing a preform for use in the manufacturing process of a hollow-core photonic crystal fiber, the method comprising: (i) providing an elongated preform jacket with a hollow inner structure, the elongated preform jacket having a first and second end; (ii) inserting a hollow capillary preform into the hollow inner structure such that the hollow capillary preform is in contact with the hollow inner structure at a contact position and protrudes out of the hollow inner structure at the first end and at the second end; (iii) at the first end, locally heating a protruding portion of the hollow capillary preform; (iv) bending the protruding portion around the first end of the preform jacket; and (v) applying additional heat to a portion of the hollow capillary preform that is bent around the elongated preform jacket to fuse it to an outer surface of the elongated preform jacket.

IPC Classes  ?

• C03B 37/012 - Manufacture of preforms for drawing fibres or filaments
• C03B 37/027 - Fibres composed of different sorts of glass, e.g. fibre optics
• C03B 23/06 - Re-forming tubes or rods by bending
• C03B 23/207 - Uniting glass rods, glass tubes, or hollow glassware

Abstract

In order to map the surface of a macromolecule, at least one fluorescent probe is introduced into a medium in which the macromolecule is embedded or will be embedded. Then, a plurality of spatial positions of the at least one fluorescent probe with regard to the macromolecule are determined via localization of the at least one singularized fluorescent probe with a simple standard deviation of no more than 2 nm. For this purpose, fluorescence light photons emitted by the singularized fluorescent probe are recorded. In addition, a bounding surface bounding the determined spatial positions with regard to the macromolecule is determined; and a three-dimensional map of at least a part of the surface of the macromolecule is generated from the bounding surface.

IPC Classes  ?

• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/1429 - Signal processing
• G01N 15/1434 - Optical arrangements

Abstract

According to a method of manufacturing a magnetic memory device, various types of magnetic memory devices can be manufactured at low cost by manufacturing a plurality of magnetic modules by using a delamination phenomenon of pattern segments and stacking the plurality of magnetic modules to complete a stacked memory device.

IPC Classes  ?

• H10N 50/01 - Manufacture or treatment
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 50/10 - Magnetoresistive devices

Abstract

A drug delivery system comprising a liposome having (a) a lipid bilayer enclosing an aqueous volume, wherein the lipid bilayer comprises i) between 30 and 75 mol percent of at least one encapsulating agent; ii) between 1 and 20 mol percent of an acid-cleavable polyethylene glycol conjugated lipid; iii) between 15 and 45 mol percent of at least one fusogenic agent, and (b) a therapeutic agent or a pharmaceutically acceptable salt thereof, encapsulated within the aqueous volume; wherein the encapsulating agent is a cationic lipid and/or a lipidated polypeptide; and wherein the liposome has a Z-Average diameter size range comprised between 20 nm and 200 nm, as determined by dynamic light scattering.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 38/46 - Hydrolases (3)
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention relates to a system (100) for assessing neurocognitive functioning, comprising a task component (101) configured to provide a task, in particular a cognitive task to a user; a capture component (102) configured to capture biomarker data of a biomarker of the user; and a processing component (103) configured to generate a biomarker response profile based on the biomarker data. The present invention further relates to a method for assessing neurocognitive functioning, comprising the steps of providing a task to a user; capturing biomarker data of a biomarker of the user; generating a biomarker response profile based on the biomarker data.

IPC Classes  ?

• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The invention relates to a system (100) for assessing anhedonia, comprising a task component (101) configured to provide a reward task to a user; a capture component (102) configured to capture biomarker data of a biomarker of the user in response to the reward task; and a processing component (103) configured to generate a biomarker response profile based on the biomarker data. The invention further relates to a method for assessing anhedonia, comprising the steps of providing a reward task, capturing biomarker data of a biomarker of the user in response to the reward task; and generating a biomarker response profile based on the biomarker data.

IPC Classes  ?

• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The invention relates to a safety apparatus (100) for monitoring a light path of a laser beam (1) and for interrupting the laser beam (1) in response to an object (2) approaching the laser beam (1), said apparatus comprising: at least one light barrier device (200) having a light source device (210) arranged to generate a safety light field (3) that extends along at least one longitudinal axis z extending in parallel with the light path of the laser beam (1), and having a sensor device (220) which has at least one sensor element (221) and which is arranged to detect the safety light field (3) and to generate a sensor signal (4) that can be varied by means of at least partial covering of the safety light field (3) by the object (2); and an interruption device (300) which is coupled to the at least one light barrier device (200) and which is arranged to interrupt the laser beam (1) according to a change in the sensor signal (4) of the at least one light barrier device (200). The invention also relates to a laser apparatus which is equipped with the safety apparatus (100), to applications of the safety apparatus (100), and to a method for monitoring a light path of a laser beam (1).

IPC Classes  ?

• G02B 26/04 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light by periodically varying the intensity of light, e.g. using choppers
• F16P 3/14 - Safety devices acting in conjunction with the control or operation of a machineControl arrangements requiring the simultaneous use of two or more parts of the body with means, e.g. feelers, which in case of the presence of a body part of a person in or near the danger zone influence the control or operation of the machine the means being photocells or other devices sensitive without mechanical contact
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors

Abstract

The present invention relates to a computer-implemented method of calculating the ranges of concentrations, of fluxes, or of reaction rate constants in a network of chemical reactions.

IPC Classes  ?

• G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• G06F 17/16 - Matrix or vector computation

Abstract

The invention relates to a method for determining at least one mass (m) that is lifted and/or carried by a user (B), with the aid of a technical device (100), preferably in the form of a smart watch and/or a sports wristband, the technical device (100) having at least one sensor (10) that is configured to measure at least one dynamic motion parameter, wherein sensor signals of the at least one sensor (10), are processed and/or analyzed to determine at least one mass (m) lifted and/or carried by the user (B).

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01L 1/00 - Measuring force or stress, in general

Abstract

The present invention provides a Computer-implemented method for determining a mapping between point patterns and corresponding coordinates in a 2D latent space, the method comprising: - for each of a set of representative point patterns, determining a set of feature vectors, wherein features of the feature vectors represent perceptual properties, - determining a dissimilarity matrix between the feature vectors of each of representative point patterns, and - performing dimensionality reduction using the dissimilarity matrix to determine the mapping from the representative point patterns to the 2D latent space.

IPC Classes  ?

• G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
• G06V 10/77 - Processing image or video features in feature spacesArrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]Blind source separation
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 40/16 - Human faces, e.g. facial parts, sketches or expressions

Abstract

A composition comprising (a) a therapeutic agent or a pharmaceutically acceptable salt thereof; (b) a PEG-monoorthoester-lipid; (c) an amphiphilic lipid; (d) a cationic lipid and/or a beta-alanyl-prolyl-cysteine methyl ester; and optionally (e) a steroid and/or a ceramide and/or DOPE. The composition for use as a medicament.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 38/46 - Hydrolases (3)
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

The present invention relates to nanocontainers for the synergistic transport of lipophilic and hydrophilic active ingredients or detection reagents. In particular, the nanocontainers according to the invention offer a possibility for diagnosing and/or treating diseases with combinations of active ingredients (therapy) and detection reagents (diagnostics), which have different solubility properties. The present invention further relates to a method for producing the nanocontainers according to the invention.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
• A61K 31/4164 - 1,3-Diazoles
• A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61K 31/5383 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/65 - Tetracyclines
• A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
• A61K 49/00 - Preparations for testing in vivo
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes