MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (Germany)
Inventor
Bloch, Immanuel
Zeiher, Johannes
Tao, Renhao
Gyger, Flavien
Ammenwerth, Maximilian
Abstract
The present disclosure relates to trapping and manipulating of neutral atoms in optical trapping potentials. In one aspect, an apparatus comprises a trapping laser system and optics for generating an optical trapping lattice at a trapping volume inside a vacuum chamber, wherein the optics for generating the optical trapping lattice are configured to generate, based on the output of the trapping laser system, a single elliptical trapping laser beam that is retroreflected and focused, using a bow-tie configuration, to the trapping volume to generate the optical trapping lattice.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (Germany)
Inventor
Bloch, Immanuel
Zeiher, Johannes
Tao, Renhao
Gyger, Flavien
Ammenwerth, Maximilian
Timme, Hendrik
Abstract
The present disclosure relates to trapping and manipulating neutral atoms for quantum computing, quantum simulation and metrology. In one aspect a method comprises loading a plurality of neutral atoms into a loading trap array arranged adjacent to or at least partially collocated with a storage trap array, selectively removing neutral atoms in a first electronic state |1> from the storage trap array, determining a trap occupancy of neutral atoms in the storage trap array in a second electronic state |2>, and of neutral atoms in the loading trap array, and moving, based on the determined trap occupancy of the neutral atoms in the storage trap array and in the loading trap array, neutral atoms from the loading trap array to one or more non-occupied trapping sites of the storage trap array. The method may further comprise shelving the neutral atoms in a shelving state.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Roldan Cuenya, Beatriz
Shaikhutdinov, Shamil
Wan, Weiming
Abstract
The present invention relates to a catalytically active material, the preparation thereof, and the use of the catalytically active material, e.g. in the catalytic oxidation of CO to CO2 or in the catalytic hydrogenation of alkyne. The catalytically active material comprises a support5 comprising a metal oxide, and atomically dispersed noble metal on the surface of the support, wherein the metal oxide is selected from TiO2, CeO2, ZnO, SnO2, Ga2O3, In2O3, ZrO2, and Fe2O3, the noble metal is selected from Pt, Pd, Rh, and Au, and the catalytically active material is obtainable by a method comprising a step of non-thermal plasma treatment in the presence of O2.
MAX PLANCK GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN EV (Germany)
Inventor
Wang, Xia
Felser, Claudia
Shekhar, Chandra
Abstract
3113, and further selecting out of these compounds the ones which contain at least a heavy metal for high spin polarization, and sort these selected compounds with increasing spin-orbit-coupling (SOC), which results in a number of compounds which are sorted with increasing catalytic activity.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Braun, Wolfgang
Abstract
The invention is related to a method of using a thermal laser evaporation (TLE) system (100), the system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source (30) comprising a source material (32), and a laser source (50) for providing laser radiation (52) at a surface (34) of the source (30) and thereby evaporating the source material (32). Further, the invention is related to a thermal laser evaporation system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source comprising a source material (32), and coupling means (12) provided by the reaction chamber (10) for coupling laser radiation (52) into the reaction chamber (10) for impinging on a surface (34) of the source (30) and thereby evaporating the source material (32).
C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
B23K 26/06 - Shaping the laser beam, e.g. by masks or multi-focusing
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Braun, Wolfgang
Abstract
The invention is related to a method of using a thermal laser evaporation (TLE) system (100), the system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source (30) comprising a source material (32), and a laser source (50) for providing laser radiation (52) at a surface (34) of the source (30) and thereby sublimating the source material (32). Further, the invention is related to a thermal laser evaporation system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source comprising a source material (32), and coupling means (12) provided by the reaction chamber (10) for coupling laser radiation (52) into the reaction chamber (10) for impinging on a surface (34) of the source (30) and thereby sublimating the source material (32).
C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
B23K 26/06 - Shaping the laser beam, e.g. by masks or multi-focusing
B23K 26/064 - Shaping the laser beam, e.g. by masks or multi-focusing by means of optical elements, e.g. lenses, mirrors or prisms
B23K 26/067 - Dividing the beam into multiple beams, e.g. multi-focusing
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
RAMOT AT TEL-AVIV UNIVERSITY LTD. (Israel)
Inventor
Elkabetz, Yechiel
Mutukula, Naresh
Arora, Sneha
Rosebrock, Daniel
Abstract
The present invention relates to a method for the generation of outer radial glial (oRG) cells of the outer sub-ventricular (oSVZ)-like region in cerebral organoids comprising (a) culturing primate stem cells in a primate stem cell medium until about day 6, thereby inducing the formation of embryonic bodies; (b) culturing the embryonic bodies as obtained in step (a) in a neural induction medium until about day 11, thereby inducing the formation of organoids; wherein an inhibitor of TGF-β, an inhibitor of BMP and an inhibitor of WNT is present from about day 2 until about day 11; (c) embedding the organoids as obtained after steps (a) and (b) and if they display a size of at least 300 μm into a hydrogel that mimics the extracellular matrix (ECM), preferably Matrigel and culturing the organoids in a cerebral differentiation medium at least until about day 40, preferably at least until about day 60 and most preferably at least until about day 80, thereby obtaining cerebral organoids with oRG cells in oSVZ-like regions, wherein the organoids in step (c) are subjected to agitation from about day 15 onward, preferably by using an orbital shaker or a spinning bioreactor; and (d) optionally isolating one or more oRG cells from the oSVZ-like region.
Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V. (Germany)
Humboldt-Universitaet zu Berlin (Germany)
Inventor
Mueller-Staehler, Julia
Grosse, Nicolai
Palato, Samuel
Abstract
A method of scattering-type scanning near-field optical microscopy (s-SNOM) comprises placing an s-SNOM tip 11 at a near-field distance from a sample 1 and subjecting the s-SNOM tip 11 to a mechanical oscillation, which provides a primary modulation, illuminating the oscillating s-SNOM tip 11 with a sequence of illumination light pulses, wherein each of the illumination light pulses hits the s-SNOM tip 11 at a specific s-SNOM tip modulation phase φi of the mechanical oscillation, collecting scattering light pulse amplitudes Si, each being created by scattering one of the illumination light pulses at the s-SNOM tip 11, using a scattering light detector device 30, collecting the s-SNOM tip modulation phase i associated to each of the collected scattering light pulse amplitudes Si, using a mechanical oscillation detector device 40, and calculating an s-SNOM near-field signal by demodulating a scattering light function S(φi) of the scattering light pulse amplitudes Si in dependency on the s-SNOM tip modulation phases φi, wherein each of the s-SNOM tip modulation phases pi is obtained by splitting an output signal of the mechanical oscillation detector device 40 into a first output signal portion X and a second output signal portion Y being phaseshifted relative to the first output signal portion X and calculating the s-SNOM tip modulation phase φi of the primary modulation from the first and second output signal portions X, Y. Furthermore, a scanning near-field optical microscopy apparatus 100 is described.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Boschker, Johannes
Braun, Wolfgang
Abstract
The present invention relates to a temperature control system (10) for adjusting a temperature (60) of a vacuum chamber (102), the temperature control system (10) comprising conduits (20) which can be thermally coupled to a chamber wall (110) of the vacuum chamber (102), a fluid pump (50), temperature adjusting means (30) comprising a heating means (32) or both a heating means (32) and a cooling means (34), and tubing (52) for fluidly connecting said conduits (20), fluid pump (50), and temperature adjusting means (30), respectively. Further, the present invention relates to a vacuum system (100) with a vacuum chamber (102), the vacuum chamber (102) comprising a chamber wall (110) enclosing a vacuum volume (106), a vacuum pump system (104) connected to the vacuum chamber (102) for evacuating the vacuum volume (106), and a temperature control system (10) for adjusting a temperature (60) of a vacuum chamber (102). In addition, the present invention relates to a method of adjusting the temperature (60) of a vacuum chamber (102) of said vacuum system (100).
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (Germany)
Inventor
Bai, Yuechen
Li, Dapeng
Baldwin, Ian T.
Yang, Caiqiong
Halitschke, Rayko
Paetz, Christian
Abstract
The present invention relates to a compound of general formula (I)
The present invention relates to a compound of general formula (I)
The present invention relates to a compound of general formula (I)
or an enantiomer, diastereomer, stereoisomer, which mediates resistance against leaf- and planthopper pests. The present invention further relates to a method of producing the compound, an enzymatic production method the compound using at least a BBL2 polypeptide, as well as a PPO, AT1, ODC, HPL, PAL, C4H, 4CL, HCT and/or C3H activity. Further envisaged are genetically modified organisms producing the compound, expression cassettes for heterologous expression of the activities, the use of corresponding polypeptides and polynucleotides for the production of the compound, a composition including the compound, as well as uses of the compound for plant protection.
C07C 235/78 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
A01N 37/42 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing within the same carbon skeleton a carboxylic group or a thio-analogue, or a derivative thereof, and a carbon atom having only two bonds to hetero atoms with at the most one bond to halogen, e.g. keto-carboxylic acids
A01P 15/00 - Biocides for specific purposes not provided for in groups
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (Germany)
Inventor
Nordmann, Thierry
Mann, Matthias
French, Lars
Abstract
The present invention relates to a Janus kinase (JAK) inhibitor and to pharmaceutical composition comprising a Janus kinase (JAK) inhibitor, respectively, for use for the treatment of toxic epidermal necrolysis (TEN) and/or Stevens-Johnson-syndrome (SJS) and/or SJS/TEN overlap. The invention further relates to a method for treatment of toxic epidermal necrolysis (TEN) and/or Stevens-Johnson-syndrome (SJS) and/or SJS/TEN overlap comprising application of a Janus kinase (JAK) inhibitor to a patient.
Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V. (Germany)
Inventor
Zeidner, Wolfgang
Gruber, Moritz
Kaunert, Karlheinz
Abstract
Disclosed is an optical fiber feedthrough (10) configured to feed through optical fibers (1) between an interior and exterior of evacuable vacuum chamber (30). The feedthrough includes at least one mounting flange (11a, 11b) configured for pressure-tight fastening to vacuum chamber and includes passage openings (12a, 12b) configured for pressure-tightly receiving a respective optical fiber. The passage openings are each provided with a sealing receptacle (13a, 13b) and a sealing element (14a, 14b) arranged therein for pressure-tightly receiving the respective optical fiber. A compression device (15a, 15b) is connected to each mounting flange, which is configured to compress the respective sealing elements axially along the respective passage openings. Also disclosed is an optical fiber assembly (20) including the feedthrough and optical fibers, and a method for passing a plurality of optical fibers between an interior and exterior of an evacuable vacuum chamber using the aforementioned feedthrough.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V (Germany)
Inventor
Lagler, Josef
Staab, Gordon
Bergler, Michael, Sebastian
Abstract
Disclosed is a method of manufacturing an optical fiber, the method comprising: providing a fiber manufacturing intermediate product, the fiber manufacturing intermediate product comprising: (i) a hollow core cane comprising a first jacket with a hollow inner structure, wherein a plurality of capillaries are fused to the first jacket within the hollow inner structure; and (ii) a second jacket around the hollow core cane; roughening an outer surface of the second jacket over a portion (310) of the second jacket; coupling an end of the fiber manufacturing intermediate product to a pressure connector (402); and drawing a hollow core photonic crystal fiber from the fiber manufacturing intermediate product.
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (Germany)
Inventor
Luther, Stefan
Parlitz, Ulrich
Lilienkamp, Thomas
Abstract
An apparatus for determining an arrhythmia of a living heart comprises a signal evaluation device receiving a signal representing a present electric activity of the heart, and determining a frequency spectrum of the signal. The apparatus further comprises a pulse generator generating a sequence of electric pulses to be applied to the heart at a pulse repetition frequency that depends on the frequency spectrum and decreases by at least 20% over the sequence.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V (Germany)
Inventor
Lagler, Josef
Bergler, Michael, Sebastian
Uebel, Patrick, Sebastian
Abstract
A method of manufacturing a preform for use in the manufacturing process of a hollow-core photonic crystal fiber, the method comprising: (i) providing an elongated preform jacket with a hollow inner structure, the elongated preform jacket having a first and second end; (ii) inserting a hollow capillary preform into the hollow inner structure such that the hollow capillary preform is in contact with the hollow inner structure at a contact position and protrudes out of the hollow inner structure at the first end and at the second end; (iii) at the first end, locally heating a protruding portion of the hollow capillary preform; (iv) bending the protruding portion around the first end of the preform jacket; and (v) applying additional heat to a portion of the hollow capillary preform that is bent around the elongated preform jacket to fuse it to an outer surface of the elongated preform jacket.
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (Germany)
Inventor
Hell, Stefan W.
Abstract
In order to map the surface of a macromolecule, at least one fluorescent probe is introduced into a medium in which the macromolecule is embedded or will be embedded. Then, a plurality of spatial positions of the at least one fluorescent probe with regard to the macromolecule are determined via localization of the at least one singularized fluorescent probe with a simple standard deviation of no more than 2 nm. For this purpose, fluorescence light photons emitted by the singularized fluorescent probe are recorded. In addition, a bounding surface bounding the determined spatial positions with regard to the macromolecule is determined; and a three-dimensional map of at least a part of the surface of the macromolecule is generated from the bounding surface.
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V. (Germany)
Inventor
Pi, Unghwan
Parkin, Stuart Papworth
Jeon, Jaechun
Kim, Jaekeun
Migliorini, Andrea
Abstract
According to a method of manufacturing a magnetic memory device, various types of magnetic memory devices can be manufactured at low cost by manufacturing a plurality of magnetic modules by using a delamination phenomenon of pattern segments and stacking the plurality of magnetic modules to complete a stacked memory device.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Zerial, Marino
Nadler, Christina
Abstract
A drug delivery system comprising a liposome having (a) a lipid bilayer enclosing an aqueous volume, wherein the lipid bilayer comprises i) between 30 and 75 mol percent of at least one encapsulating agent; ii) between 1 and 20 mol percent of an acid-cleavable polyethylene glycol conjugated lipid; iii) between 15 and 45 mol percent of at least one fusogenic agent, and (b) a therapeutic agent or a pharmaceutically acceptable salt thereof, encapsulated within the aqueous volume; wherein the encapsulating agent is a cationic lipid and/or a lipidated polypeptide; and wherein the liposome has a Z-Average diameter size range comprised between 20 nm and 200 nm, as determined by dynamic light scattering.
A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
20.
SYSTEM AND METHOD FOR ASSESSING NEUROCOGNITIVE FUNCTIONING
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Spoormaker, Victor
Fietz, Julia
Abstract
The present invention relates to a system (100) for assessing neurocognitive functioning, comprising a task component (101) configured to provide a task, in particular a cognitive task to a user; a capture component (102) configured to capture biomarker data of a biomarker of the user; and a processing component (103) configured to generate a biomarker response profile based on the biomarker data. The present invention further relates to a method for assessing neurocognitive functioning, comprising the steps of providing a task to a user; capturing biomarker data of a biomarker of the user; generating a biomarker response profile based on the biomarker data.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Spoormaker, Victor
Brendler, Andy
Abstract
The invention relates to a system (100) for assessing anhedonia, comprising a task component (101) configured to provide a reward task to a user; a capture component (102) configured to capture biomarker data of a biomarker of the user in response to the reward task; and a processing component (103) configured to generate a biomarker response profile based on the biomarker data. The invention further relates to a method for assessing anhedonia, comprising the steps of providing a reward task, capturing biomarker data of a biomarker of the user in response to the reward task; and generating a biomarker response profile based on the biomarker data.
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (Germany)
Inventor
Küken, Anika
Basler, Georg
Onana Eloundou Mbebi, Jeanne Marie
Nikoloski, Zoran
Abstract
The present invention relates to a computer-implemented method of calculating the ranges of concentrations, of fluxes, or of reaction rate constants in a network of chemical reactions.
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V. (Germany)
Inventor
Kaunert, Karlheinz
Kurzan, Bernd
Abstract
The invention relates to a safety apparatus (100) for monitoring a light path of a laser beam (1) and for interrupting the laser beam (1) in response to an object (2) approaching the laser beam (1), said apparatus comprising: at least one light barrier device (200) having a light source device (210) arranged to generate a safety light field (3) that extends along at least one longitudinal axis z extending in parallel with the light path of the laser beam (1), and having a sensor device (220) which has at least one sensor element (221) and which is arranged to detect the safety light field (3) and to generate a sensor signal (4) that can be varied by means of at least partial covering of the safety light field (3) by the object (2); and an interruption device (300) which is coupled to the at least one light barrier device (200) and which is arranged to interrupt the laser beam (1) according to a change in the sensor signal (4) of the at least one light barrier device (200). The invention also relates to a laser apparatus which is equipped with the safety apparatus (100), to applications of the safety apparatus (100), and to a method for monitoring a light path of a laser beam (1).
G02B 26/04 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light by periodically varying the intensity of light, e.g. using choppers
F16P 3/14 - Safety devices acting in conjunction with the control or operation of a machineControl arrangements requiring the simultaneous use of two or more parts of the body with means, e.g. feelers, which in case of the presence of a body part of a person in or near the danger zone influence the control or operation of the machine the means being photocells or other devices sensitive without mechanical contact
G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
24.
METHOD AND TECHNICAL DEVICE, ESPECIALLY SMART DEVICE, IN PARTICULAR A SMART WATCH, FOR DETERMINING AT LEAST ONE MASS
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Höfer, Katharina
Wagner, Samuel
Abstract
The invention relates to a method for determining at least one mass (m) that is lifted and/or carried by a user (B), with the aid of a technical device (100), preferably in the form of a smart watch and/or a sports wristband, the technical device (100) having at least one sensor (10) that is configured to measure at least one dynamic motion parameter, wherein sensor signals of the at least one sensor (10), are processed and/or analyzed to determine at least one mass (m) lifted and/or carried by the user (B).
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Huang, Xingchang
Singh, Gurprit
Seidel, Hans-Peter
Memari, Pooran
Ritschel, Tobias
Abstract
The present invention provides a Computer-implemented method for determining a mapping between point patterns and corresponding coordinates in a 2D latent space, the method comprising: - for each of a set of representative point patterns, determining a set of feature vectors, wherein features of the feature vectors represent perceptual properties, - determining a dissimilarity matrix between the feature vectors of each of representative point patterns, and - performing dimensionality reduction using the dissimilarity matrix to determine the mapping from the representative point patterns to the 2D latent space.
G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
G06V 10/77 - Processing image or video features in feature spacesArrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]Blind source separation
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 40/16 - Human faces, e.g. facial parts, sketches or expressions
26.
A LIPID DRUG DELIVERY SYSTEM FOR INCREASED ENDOSOMAL ESCAPE
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Zerial, Marino
Nadler, Christina
Abstract
A composition comprising (a) a therapeutic agent or a pharmaceutically acceptable salt thereof; (b) a PEG-monoorthoester-lipid; (c) an amphiphilic lipid; (d) a cationic lipid and/or a beta-alanyl-prolyl-cysteine methyl ester; and optionally (e) a steroid and/or a ceramide and/or DOPE. The composition for use as a medicament.
A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
C12N 15/90 - Stable introduction of foreign DNA into chromosome
27.
SYNERGISTIC TRANSPORT OF LIPOPHILIC AND HYDROPHILIC ACTIVE SUBSTANCES IN NANOPARTICLES
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Rudolph, David
Feldmann, Claus
Napp, Joanna
Alves, Frauke
Abstract
The present invention relates to nanocontainers for the synergistic transport of lipophilic and hydrophilic active ingredients or detection reagents. In particular, the nanocontainers according to the invention offer a possibility for diagnosing and/or treating diseases with combinations of active ingredients (therapy) and detection reagents (diagnostics), which have different solubility properties. The present invention further relates to a method for producing the nanocontainers according to the invention.
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
A61K 31/5383 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V. (Germany)
Inventor
Pi, Unghwan
Parkin, Stuart Papworth
Migliorini, Andrea
Jeon, Jaechun
Abstract
A method of operating a magnetic memory device includes: (i) applying a first current to a free layer of a magnetic tunnel junction structure, which includes a magnetic translation unit (MTU) extending between a first magnetic pad and a second magnetic pad, and a tunnel barrier layer and a pinned layer stacked on the MTU, so that a multi-domain is established within the MTU, (ii) applying a magnetic field to the free layer so that the magnetization direction of the MTU switches to become anti-parallel to the magnetization directions of the first magnetic pad and the second magnetic pad, (iii) applying a second current to the free layer so that a portion of the multi-domain penetrates into the first magnetic pad, and (iv) applying another magnetic field to the free layer so that the magnetization direction of the first magnetic pad switches.
G11C 19/08 - Digital stores in which the information is moved stepwise, e.g. shift registers using magnetic elements using thin films in plane structure
G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Antonyshyn, Iryna
Aras, Fatma
Burkhardt, Ulrich
Schmidt, Marcus
Schlögl, Robert
Grin, Juri
Abstract
The present invention relates to an electrode comprising or consisting of an electrocatalyst, the electrocatalyst comprising a metal boride, wherein the metal boride comprises at least one element M1 selected from Ti, Zr and Hf, and at least one element M2 selected from Co, Ni, Ru, Rh, Pd, Ir and Pt; and the metal boride contains more than 10 atomic % of M2. The present invention also provides an electrode obtainable by subjecting the electrode to an electrocatalytic reaction. It also relates to an electrolyzer comprising said electrode. It is also concerned with a method for producing an electrode, and use of an electrode in an electrocatalytic reaction.
C25B 11/067 - Inorganic compound e.g. ITO, silica or titania
C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Görlich, Dirk
Aksu, Metin
Rymarenko, Oleh
Güttler, Thomas
Rees, Renate
Gregor, Kathrin
Taxer, Waltraud
Schünemann, Jürgen
Dobbelstein, Matthias
Stegmann, Kim Maren
Dickmanns, Antje
Abstract
The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2 and that have been selected for potent cross-reaction and cross-neutralization between the original Wuhan strain and the Alpha, Beta, Gamma, Delta, and Mu variants of concern.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V. (Germany)
Inventor
Hinnah, Konstantin
Wilhelm, Jonas
Johnsson, Kai
Abstract
The invention relates to a method to query a molecular interaction between a first and a second partner moiety, wherein the first partner moiety is associated to a first partial effector sequence, and the second partner moiety is associated to a second partial effector sequence. The first and second partial effector sequences constitute a functional split HaloTag system. The first partner is a peptide sequence encoded by a polynucleotide sequence, and is physically associated with the polynucleotide sequence. The method according to the invention comprises the steps of: a) contacting the first and the second partner moiety in the presence of a HaloTag substrate covalently linked to a separation function; b) separating the first partner moiety being attached to the separation function; c) determining a molecular interaction between the first partner moiety and the second partner moiety by detecting the presence of the polynucleotide sequence.
Max-Planck-Gesellschaft Zur Fõrderung Der Wissenschaften E.V. (Germany)
Inventor
Mannhart, Jochen
Abstract
A three-dimensional arrangement of nanoscopic devices, the arrangement comprises a scaffold structure; and a plurality of nanoscopic devices, the nanoscopic devices being configured to exhibit a nonreciprocal transmission probability of electron quantum wave packets, wherein the nanoscopic devices are attached to the scaffold structure, wherein a majority of the nanoscopic devices are oriented with one and the same transmission direction of higher transmission probability of the electron quantum wave packets.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Sitti, Metin
Wrede, Paul
Aghakhani, Amirreza
Abstract
Disclosed is an acoustic trapping assembly (100) comprising a focused ultrasound transducer (102) and a plurality of hollow microrobots (110). The focused ultrasound transducer (102) is configured for generating an acoustic pressure maximum within a focal area (106) of a focused ultrasound beam (104) emitted by the focused ultrasound transducer (102) with the plurality of hollow microrobots (110) being acoustically trapped within the acoustic pressure maximum under fluid flow in a fluidic medium (120). The hollow microrobots (110) comprise solid shells (112) filled with gas.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
VRIJE UNIVERSITEIT AMSTERDAM (Netherlands)
Inventor
Yiting, Xia
Jialong, Li
Yiming, Lei
De Marchi, Federico
Raj, Joshi
Chandrasekaran, Balakrishnan
Abstract
The present invention relates to methods and devices for transmitting packets in a data center network (DCN), the data center comprising a multitude of host servers, a multitude of top-of- rack, ToR, switches connected to the host servers and an optical network fabric connected to the multitude of top-of-rack switches, wherein the optical network fabric operates according to a given schedule, wherein the given schedule defines, for each time slice in a sequence of time slices, which pairs of top-of-rack switches are connected by a dedicated optical circuit established by an optical controller of the optical network fabric for said time slice, wherein a top-of- rack switch: synchronizes to another top-of-rack switch; receives a packet at an ingress port; and sends the packet to an egress port. According to the invention, synchronizing comprises sending a synchronization message to said another top-of-rack switch in-band.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
PHILIPPS-UNIVERSITÄT MARBURG (Germany)
Inventor
Erb, Tobias Jürgen
Luo, Shanshan
Heider, Johann
Abstract
The present invention relates to a method and system for producing adenosine triphosphate (ATP) through an acid/aldehyde-ATP (AAA) cycle in an electrochemical cell.
36.
HARDWARE-EFFICIENT NEUTRAL ATOM QUANTUM COMPUTING METHOD AND DEVICE
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (Germany)
Inventor
Blatt, Sebastian
Bloch, Immanuel
Alberti, Andrea
Zeiher, Johannes
Festa, Lorenzo
Melchner, Max
Eberhard, Robin
Zhang, Zhao
Mours, Kevin
Tsevas, Dimitrios
Abstract
The present disclosure relates to a device and a method for quantum computing using a plurality of neutral atoms in an array of optical traps, wherein a first internal state of the neutral atoms serves as qubit ground state |o>, and a second internal state serves as qubit excited state |1>. According to the present disclosure, a local single-qubit gate operation on a qubit may be performed comprising locally and selectively illuminating the qubit prepared in a superposition state |s> of qubit ground state |o> and qubit excited state |1> with a qubit addressing laser at a first qubit addressing laser frequency to cause a differential Stark shift for the qubit ground state |o> and the qubit excited state |1>, Further, a local two-qubit gate operation may be performed on a pair of qubits comprising locally and selectively illuminating the pair of qubits prepared in the qubit ground state |o> with the qubit addressing laser at a second qubit addressing laser frequency for coupling the pair of qubits to a Rydberg state |r> of the neutral atoms preferably via a third internal state c> of the neural atoms that can serve as an intermediate state of a two-photon transition from the qubit ground state |o> to the Rydberg state |r>.
FUNDACIÓN COMUNIDAD VALENCIANA CENTRO INVESTIGACIÓN PRINCIPE FELIPE (Spain)
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Vicent Docón, María Jesús
Conejos Sánchez, Inmaculada
Pegoraro, Camilla
Karpova, Ekaterina
Sogorb, Gloria
Felip Leon, Carles
Nebot Carda, Vicent Josep
Schwille, Petra
Qutbuddin, Yusuf
Abstract
The present invention relates to polyproline-based block copolymers and compositions thereof, which e.g. are useful for delivering active ingredients, including nucleic acids, and/or imaging agents to target cells or tissues.
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (Germany)
Inventor
Famulok, Michael
Prusty, Deepak
Volker, Adam
Irsen, Stephan
Abstract
The present invention relates to a nucleic acid-based assembly comprising: at least one nucleic acid aptamer, and at least one nucleic acid motif designed to physically capture a drug. The nucleic acid motif may comprise one or more photo-responsive moieties that effect the release of the drug upon irradiation. The aptamer and the nucleic acid motif each can be covalently linked to one or more lipids, and the lipid-modified aptamer and nucleic acid motif may form the assembly through noncovalent interaction. The invention further relates to use of the nucleic acid-based assembly in the treatment of cancer.
C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
39.
MODIFIED CELL, PHARMACEUTICAL COMPOSITION AND METHOD OF PREPARING A MODIFIED CELL
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Bücher, Jochen Estebano Hernandez
Plazman, Yilia
Spatz, Joachim
Abstract
The present invention relates to a modified cell, in particular a modified blood cell, having a cell membrane encapsulating a lumen of the modified cell, wherein a functional lipid is incorporated into the cell membrane, wherein the functional lipid has a bonding site capable of bonding to a molecule having a functional motif, and wherein the bonding site is located on an external surface of the cell membrane. Further, the present invention concerns a pharmaceutical composition, the use of the modified cell and/or the pharmaceutical composition for use as a medicament or as a contrast agent as well as a method of modifying a cell.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
C12N 5/078 - Cells from blood or from the immune system
40.
MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS
The present invention relates to certain macrocyclic compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment or prevention of a disease associated with and/or caused by proteasome or immunoproteasome, selected from a cancer, an infectious disease, an inflammatory disease, and autoimmune disease.
The present invention relates to certain macrocyclic compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment or prevention of a disease associated with and/or caused by proteasome or immunoproteasome, selected from a cancer, an infectious disease, an inflammatory disease, and autoimmune disease.
A61K 31/439 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/5386 - 1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
41.
METHOD AND APPARATUS FOR DETERMINING NANOPARTICLE PROPERTIES OF NANOPARTICLES IN A SAMPLE
Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V. (Germany)
Inventor
Sandoghdar, Vahid
Blessing, Martin
Kashkanova, Anna D.
Gemeinhardt, Andre
Abstract
A method of determining nanoparticle properties of nanoparticles (2) included in a sample (1), comprising the steps of collecting sequential frames of images by employing an interferometric microscope device (110), wherein the sample (1) is illuminated with illumination light (3) from a coherent light source device (111) and the images are created by scattering light (4) from the nanoparticles (2) superimposed with non-scattered reference light, said scattering light and reference light having a wavelength larger than a cross-sectional dimension of the nanoparticles (2), tracking the nanoparticles (2) in the sequential frames of images, wherein at least one interferometric point spread function (iPSF) feature of each of the nanoparticles (2) is established and nanoparticle trajectory motion data are determined for each nanoparticle (2), comprising the nanoparticle positions in each frame, for each nanoparticle (2), calculating a nanoparticle size d from the trajectory motion data of the nanoparticle and calculating an interferometric nanoparticle contrast from the at least one iPSF feature of the nanoparticle.
G01N 15/1433 - Signal processing using image recognition
G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Jahnke, Timotheus
Wang, Yuanzhen
Spatz, Joachim
Abstract
The present invention concerns a lithium metal electrode, in particular for a lithium ion battery, comprising a three-dimensional network of metal fibers, wherein the metal fibers are directly in contact to one another, wherein the metal fibers have a thickness and/or width in the range of 0.25 to 200 μm, and wherein metallic lithium is provided on the surface of the metal fibers of the tree-dimensional network of metal fibers. Further, the present invention concerns a Method of manufacturing a lithium metal electrode, wherein the method comprises the steps of a) providing a three-dimensional network of metal fibers, wherein the metal fibers are directly in contact to one another, wherein the metal fibers have a thickness and/or width in the range of 0.25 to 200 μm; and b) providing a layer of metallic lithium on the fibers of the three-dimensional network of metal fibers.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Robbins, Trace
Donovan, Joseph
Baier, Herwig
Abstract
A shutter device (100) comprises a backplane (10), a front cap (20), and a single shutter blade (30) mounted between the backplane (10) and the front cap (20), wherein the shutter blade (30) is connectable with a drive mechanism and movable between an open state and a closed state.
G02B 26/02 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light
G02B 21/16 - Microscopes adapted for ultraviolet illumination
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Gregor, Kathrin
Solà Colom, Mireia
Huyton, Trevor
Görlich, Dirk
Abstract
The present invention relates to VHH antibodies that specifically bind to components of nuclear pore complexes of human cells and other species. Further, the present invention relates to the labelling of VHH antibodies through maleimide chemistry and ectopic cysteine residues. Further, the present invention relates to a method for forming a stabilizing, structural disulfide bond in initially reduced VHH antibodies.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Mercier, Raphael
Jing, Juli
Lian, Qichao
Durand, Stephanie
Abstract
The present invention relates to a method for increasing the frequency of meiotic crossover in a plant, plant part, plant tissue culture or plant cell comprising inhibiting in said plant, plant part, plant tissue culture or plant cell the expression and/or the function of the proteins ZYP1 and RECQ4. The present invention furthermore relates to a plant, plant part, plant tissue culture or plant cell, wherein the expression and/or the function of the proteins ZYP1 and RECQ4 is inhibited.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Göpfrich, Kerstin
Abele, Tobias
Maurer, Stefan
Abstract
The present invention relates to a method for identifying and separating a specific component of interest from a plurality of components, the method comprises the steps of: A) providing a dispersion comprising the plurality of components, optionally enclosed in compartments, and a photoresist, wherein among the plurality of components at least one portion shows a factor of interest; B) scanning of the dispersion for at least one factor of interest to identify said at least one portion among the plurality of components or optionally of the compartments and selecting those components or optionally compartments of interest and attributing a location to the components or optionally compartments of interest within the dispersion; C) applying a light to at least one part of the dispersion for curing said photoresist either attributed to the components of interest or not attributed to the components of interest; and D) separating a component from parts of the dispersion with cured photoresist from components from other parts of the dispersion with uncured photoresist. Further, the present invention relates to a device configured to carry out the method according to any one of the preceding claims.
C08F 299/02 - Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers from unsaturated polycondensates
47.
A METHOD FOR FABRICATING A MAGNETIC SPIN VALVE DEVICE COMPRISING FERROMAGNETIC LAYERS WITH NON-COLLINEAR MAGNETIZATIONS
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (Germany)
Inventor
Khaydukov, Yury
Keller, Thomas
Keimer, Bernhard
Morari, Roman
Sidorenko, Anatolie
Abstract
A method for fabricating a magnetic device comprises providing a layer stack, the layer stack comprising a substrate, a first ferromagnetic layer disposed above the substrate, the first ferromagnetic layer comprising a uniaxial magnetic anisotropy including an easy axis, a non-magnetic layer disposed on the first ferromagnetic layer, a second ferromagnetic layer disposed on the non-magnetic layer, the second ferromagnetic layer comprising a unidirectional anisotropy, and an antiferromagnetic layer disposed on the second ferromagnetic layer, the antiferromagnetic layer comprising a Néel temperature TN; heating the layer stack above the Néel temperature TN of the antiferromagnetic layer; applying a magnetic field HCL to the layer stack, the magnetic field HCL comprising a magnetic field direction having an arbitrary angle with respect to the easy axis; cooling the layer stack below the Néel temperature TN of the antiferromagnetic layer with the magnetic field HCL applied; and removing the magnetic field HCL.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Boschker, Hans
Braun, Wolfgang
Abstract
The present invention relates to a source (100) for providing a directed flow of source material (80) thermally evaporated and/or sublimated by a laser beam (68) and emerging in a flow direction (84) from the source (100) at a flow opening (90) of a source chamber (10) of the source (100). Further, the present invention relates to a deposition system (200) for coating of a substrate (222), comprising a reaction chamber (210) enclosing a reaction volume (212), a substrate arrangement means (220) for arranging the substrate (222) to be coated within the reaction volume (212), and said source (100) for providing a directed flow (82) of evaporated and/or sublimated source material (80), wherein the reaction chamber (210) comprises a source opening (230) in a reaction chamber wall (216) of the reaction chamber (210) such that a line of sight (240) between the source opening (230) and the substrate (222) to be coated is free, and wherein the source (100) is sealingly arranged with its flow opening (90) at the source opening (230).
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Bode, Helge
Chaudhury, Paushali
Bode, Edna
Obermeier, Timo
Rill, Alexander
Abstract
The present invention relates to a method for finding global regulators in order to induce or increase production of target secondary metabolites. The method comprises providing a bacterium indicator strain producing two fluorescent reporter signals under the same control of two different biosynthetic gene clusters (BGC), preferably highly expressed BGC, performing random mutagenesis in said bacterium indicator strain, and selecting mutant bacteria not producing said reporter signals. The invention also relates to a method to activate the production of target secondary metabolites, and to a CRISPR/Cas based single plasmid to delete or inactivate a global regulator and/or activate a BGC. Finally, the inventive method can be performed in high-throughput format allowing to speed-up the procedure.
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12N 15/65 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression using markers
C12N 15/67 - General methods for enhancing the expression
C12P 1/04 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes by using bacteria
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
50.
FLANGE, FLANGED JOINT, VACUUM AND/OR REACTION CHAMBER, AND SYSTEM FOR THERMAL LASER EPITAXY
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Braun, Wolfgang
Boschker, Hans
Abstract
The invention relates to a flange (10) made of an aluminum alloy, wherein the flange (10) is arranged sealedly or can be arranged sealedly at an opening (104) in a chamber wall (102) of a vacuum and/or reaction chamber (100), and wherein the flange (10) has a peripheral and planar sealing surface (20) for sealing the opening (104) in the vacuum and/or reaction chamber (100) with respect to the surroundings, which sealing surface is adjoined by a cutting edge (30) for a knife-edge seal (40). The invention also relates to a flanged joint (50) comprising a first flange element (52), a second flange element (54), a sealing ring (60), and a clamping device (70), wherein the first flange element (52) and the second second flange element (54) each have a cutting edge (30) for a knife-edge seal (40), wherein the sealing ring (60) is made of a softer material than the cutting edges (30) and can be arranged between the first flange element (52) and the second second flange element (54), and, in order to seal the flanged joint (50), the first flange element (52) and the second flange element (54) can be pressed against one another by means of the clamping device (70), so that the cutting edge (30) of the first flange element (52) and the cutting edge (30) of the second flange element (54) are pressed into the sealing ring (6) from opposing sides. The invention also relates to a vacuum and/or reaction chamber (100) having a chamber wall (102) and an opening (104) in the chamber wall (102), wherein the vacuum and/or reaction chamber (100) also has a flange (10) of this kind for the opening (104), wherein the flange (10) is arranged sealedly at the opening (104). The invention also relates to a system (200) for thermal laser epitaxy (TLE), comprising at least one vacuum and/or reaction chamber (100) of this kind, wherein the vacuum and/or reaction chamber (100) has a chamber wall (102) having one or more openings (104) at each of which one flange (10) is arranged.
MAX PLANCK GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN EV (Germany)
Inventor
Parkin, Stuart S.P.
Yang, See-Hun
Pi, Ungh-Wan
Jeong, Jaewoo
Abstract
The present invention relates to racetrack memory array devices, and more specifically, to a manufacturing method of racetrack memory arrays with integrated magnetic tunnel junction for read/write.
H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Göpfrich, Kerstin
Abele, Tobias
Jahnke, Kevin
Walther, Tobias
Wegener, Martin
Messer, Tobias
Hippler, Marc
Abstract
The present invention relates to a method for non-invasive production of defined structures inside compartments, wherein the method comprises the steps of: providing a compartment having an inside filled with a liquid, comprising a photoresist, and applying light to the inside of the compartment including the photoresist, wherein the light has a focal point inside the compartment and initiates a chemical reaction of the photoresist at the focal point, creating a defined structure. Further, the present invention relates to a compartment, having an inside, surrounded by a compartment wall, wherein the compartment comprises a defined structure obtainable by a method according to any one of the preceding claims.
B29C 64/135 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask the energy source being concentrated, e.g. scanning lasers or focused light sources
B29K 71/00 - Use of polyethers as moulding material
G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
G03F 7/029 - Inorganic compoundsOnium compoundsOrganic compounds having hetero atoms other than oxygen, nitrogen or sulfur
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Erb, Tobias
Marchal, Daniel
Abstract
The present invention provides a Glycolyl-CoA Carboxylase (GCC), wherein said GCC is characterized in that: it comprises an amino acid sequence having at least 60 % sequence identity to SEQ ID NO: 1, and it has one or more amino acid substitutions, deletions or insertions at a position selected from the group consisting of positions 20 and 100 in the amino acid sequence shown in SEQ ID NO: 1 or at a position corresponding to any of these positions, preferably wherein the GCC has an improved activity over a reference GCC, preferably wherein the reference GCC comprises the amino acid sequence of SEQ ID NO: 1.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Höfer, Katharina
Pozhydaieva-Weber, Nadiia
Abstract
The present invention relates to a method for genetically engineering the genome of phages at a target locus by CRISPR-Cas, where the phases the genome of which is to be genetically engineered are comprises in a bacterial cell, a L-form bacterium, a cell-free transcription-translation system (TXTL) system or a bacterial cell lysate expressing a Tet-like protein.
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E. V. (Germany)
Inventor
Dreher, Yannik
Goepfrich, Kerstin
Abstract
In a first aspect the present invention relates to a system for continuous measurement of osmolarity in situ. Said system comprises phase-separated membrane enclosed compartment as the sensor in osmolarity; detection means: a processing unit, and, optionally, an output unit of absolute or relative osmolarity and/or osmolarity changes. Further, the use of the phase-separated membrane enclosed compartment, whereby the membrane is permeable to a solvent and non-permeable to the osmotically active substance for non-invasive osmolarity measurement in a liquid system is described. In addition, a method for determining osmolarity and/or osmolarity change in a system is provided including the phase-separated membrane enclosed compartment, whereby the membrane is a permeable to a solvent and non-permeable to the osmotically active substance. Finally, a set of phase-separated membrane enclosed compartment, whereby the membrane is permeable to a solvent and non-permeable to the osmotically active substance, having predetermined different inner osmolarities useful for calibrations of osmolarity of an osmolarity measuring system is disclosed.
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Sendker, Franziska Luisa
Graf Von Hochberg Freiherr Zu Fürstenstein, Georg Karl Albert
Abstract
The invention relates to ancestral citrate synthase proteins which are capable of forming at least 3 different complexation states simultaneously. The invention further relates to compositions comprising the ancestral citrate synthase proteins, use of the ancestral citrate synthase proteins or compositions, nucleic acids encoding the ancestral citrate synthase proteins, and methods of purifying the ancestral citrate synthase proteins.
MAX PLANCK GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN EV (Germany)
Inventor
Parkin, Stuart S.P.
Farinha, André
Abstract
The present invention relates to a method for manipulating domain walls (DWs) in a magnetic ribbon, which method comprises imposing a curvilinear 3D structure upon at least one region of the magnetic ribbon. Moreover, the invention relates to a curvilinear 3D magnetic ribbon, which extends between two ends and which has at least one twisted region between its two ends wherein the twisted region exhibits an absolute torsion angle over its length of 1-70°, and the torsion angle has an increase per unit length of 0.5-60°.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
SOUTH AFRICAN NATIONAL PARKS (South Africa)
GEPE GEIMUPLAST GMBH (Germany)
Inventor
Heine, Georg
Vorneweg, Bernd
Wikelski, Martin Christoph
Müller, Ursula Rosa
Koblitz, Jens
Van Schalkwyk, Ockert Louis
Viljoen, Pauli
Schöpf, Johann
Hutsteiner, Josef
Wild, Timm
Abstract
The present disclosure relates to an electronic tag for behavioural monitoring of animals, the electronic tag comprising a microprocessor and at least one sensor. The electronic tag is configured to obtain, via the at least one sensor, movement data of an animal to which the electronic tag is attached and to determine, based on the obtained movement data, a behaviour of the animal. The disclosure further encompasses a corresponding method as well as an ear tag.
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (Germany)
Inventor
Leuchs, Gerd
Abstract
A method sequentially transmits signals of polarization states of light through an optical fiber. The optical fiber being a polarization preserving optical fiber. For each signal, a signal state is prepared as one out of a set of at least two non-orthogonal polarization states of light and sent through the optical fiber from a sender site to a receiver site. A method for quantum key distribution using polarization states of light is performed, wherein an alphabet of elementary information values is encoded in a set of non-orthogonal polarization states of light such that each elementary information value is represented by at least one of the polarization states. A classical message of elementary information values out of the alphabet is prepared, wherein the respective polarization states corresponding to the elementary information values of the classical message are prepared at a sender site as signal states.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V (Germany)
Inventor
Liu, Laura Na
Li, Jianxiong
Kaissner, Robin
Abstract
The invention relates to an optical component comprising a metasurface, wherein the metasurface comprises a repeating pattern of unit cells, wherein each unit cell comprises at least two different scattering structures, wherein first scattering structures are at least partially contacting a first substance having a first refractive index and second scattering structures are at least partially contacting a second substance, which differs from the first substance, wherein the second substance provides a refractive index which is variable depending on an electrical control signal, wherein a plurality of pairs of first scattering structures contacting the first substance and second scattering structures contacting the second substance are arranged row-wise on electrodes, wherein electrodes supporting neighboring rows of pairs of first and second scattering structures are electrically separated from each other, and a LIDAR system comprising such an optical component. Furthermore, the invention relates to a method for amending a deflection angle of such an optical component.
G02F 1/29 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the position or the direction of light beams, i.e. deflection
61.
INHIBITORS OF ALPHA-HEMOLYSIN OF STAPHYLOCOCCUS AUREUS
The present invention relates to novel inhibitors of α-hemolysin of formula (I) and the use thereof for the prophylaxis and treatment of infections caused by Staphylococcus aureus; especially S. aureus lung infections.
The present invention relates to novel inhibitors of α-hemolysin of formula (I) and the use thereof for the prophylaxis and treatment of infections caused by Staphylococcus aureus; especially S. aureus lung infections.
C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
A61K 31/554 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
C07D 241/44 - Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Müller, Franz-Josef
Brändl, Björn Fabian
Schuldt, Bernhard
Rohrandt, Christian
Van Bömmel, Alena
Kretzmer, Helene
Abstract
The present invention relates to a method for the diagnosis and/or classification of a disease in a subject based on the genetic and/or epigenetic information of a sample obtained from the subject, the method comprising the steps of: a) providing data from said sample, wherein said data comprises genetic and/or epigenetic information of a random subset of genomic positions: b) assigning said sample to a sample class based on genetic and/or epigenetic information of said random subset of genomic positions by employing a computational model, which discriminates a plurality of sample classes based on genetic and/or epigenetic information of a set of genomic positions comprising said random subset, wherein the computational model has been trained with pre-determined genetic and/or epigenetic information obtained from a plurality of pre-classified samples of known diseases and wherein said computational model processes the genetic and/or epigenetic information of a genomic position of said random subset independently of the genetic and/or epigenetic information of another genomic position of said random subset, wherein said computational model is preferably in the form of a linear classifier with independent feature sampling.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V. (Germany)
Inventor
Singh, Kanwarpal
Sharma, Gargi
Abstract
A confocal microscopy apparatus 100 for imaging a sample 2 under investigation by chromatic confocal microscopy comprises an illumination source device 10 being arranged for creating illumination light 1 having an illumination spectrum covering a plurality of illumination wavelengths, a focusing device 40 including at least one focusing lens 41 being configured for focusing the illumination light 1 along an imaging axis z into a plurality of wavelength-dependent focal planes in an axial imaging range of a sample 2 to be investigated, wherein the at least one focusing lens 41 is further arranged for collecting scattering light 3 created in the focal planes of the sample 2, and a detector device 50 being arranged for spectrally resolved detecting of the scattering light 3, wherein the at least one focusing lens 41 is made of a dispersive focusing lens 41 material with an Abbe number equal to or below 8, like e. g. ZnSe. Furthermore, a confocal microscopy method for imaging a sample 2 to be investigated by chromatic confocal microscopy is described.
Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V. (Germany)
Inventor
Lincoln, Richard
Butkevich, Alexey N.
Bossi, Mariano L.
Abstract
The invention relates to novel caging-group-free photactivatable fluorescent dyes having the structural formula (I) as well as to the corresponding photoactivated fluorescent dyes having the structural formula (II). The invention further relates to the use of the photoactivatable compounds as such or after photoactivation, in particular as fluorescent tags, analytical reagents and labels in optical microscopy, imaging techniques, protein tracking, nucleic acid labeling, glycan analysis, capillary electrophoresis, flow cytometry or as a component of biosensors, or as analytical tools or reporters in microfluidic devices or nanofluidic circuitry.
The invention relates to novel caging-group-free photactivatable fluorescent dyes having the structural formula (I) as well as to the corresponding photoactivated fluorescent dyes having the structural formula (II). The invention further relates to the use of the photoactivatable compounds as such or after photoactivation, in particular as fluorescent tags, analytical reagents and labels in optical microscopy, imaging techniques, protein tracking, nucleic acid labeling, glycan analysis, capillary electrophoresis, flow cytometry or as a component of biosensors, or as analytical tools or reporters in microfluidic devices or nanofluidic circuitry.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Weil, Tanja
Hartenfels, Jan
Kaygisiz, Kübra
Synatschke, Christopher
Münch, Jan
Rauch, Lena
Abstract
The present invention relates to self-assembling peptide amphiphiles consisting of a non-self-assembling peptide moiety having a positive net charge under physiological pH, and a hydrophobic moiety covalently coupled to the peptide moiety, wherein the peptide moiety is composed of a positively charged peptide part and a β-sheet forming peptide part, wherein the hydrophobic moiety is covalently coupled to the β-sheet forming peptide part, wherein the peptide amphiphiles self-assemble into fibrils and form μm-sized aggregates in aqueous medium, and wherein the fibrils are efficiently degradable in cells. The peptide amphiphiles of the present invention are useful as viral transduction enhancers for retroviral gene delivery into cells. Thus, the present invention further relates to the use of peptide amphiphiles as retroviral transduction enhancers in retroviral gene delivery into cells, and to methods for retroviral gene delivery into cells in presence of peptide amphiphiles.
C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
A61K 31/00 - Medicinal preparations containing organic active ingredients
B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
C07K 7/00 - Peptides having 5 to 20 amino acids in a fully defined sequenceDerivatives thereof
A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
66.
SCREENING AND USES OF GLUTAMINE SYNTHETASE MODULATORS
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Martins Garcia, Bruna
Farah Pernas, Lena
Abstract
The present invention relates to an in vitro bioassay to identify glutamine synthetase activators and inhibitors on the basis of one or more glutamine markers such as citrate, a metabolite derived from the mevalonate pathway, a glutamine responsive mRNA or proteins, such as HMGCR or SREBP2. Disclosed herein are also glutamine synthetase activators and inhibitors identified by the inventive method for use to stimulate or inhibit the synthesis of a metabolite derived from the mevalonate pathway, such as cholesterol, and to treat a disease associated with deregulated levels of said metabolite, such as cancer.
MAX PLANCK GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN EV (Germany)
Inventor
Parkin, Stuart S.P.
Pal, Banabir
Hazra, Binoy Krishna
Yang, See-Hun
Abstract
A method for switching magnetic moments in a magnetic material by:
a) heating a system formed from
a layer of magnetic material and
a layer of a metal contacting and forming an interface with one surface of the magnetic material layer,
the heating step increasing the temperature to at least 1 to 100 K above the blocking temperature of the magnetic material,
b) applying current pulses having a fall time to the system at least at a point in time when the system is heated to at least 1 to 100 K above the blocking temperature of the magnetic material, thereby generating a spin texture in the magnetic material layer and
c) then cooling the system to a temperature of below the blocking temperature at a cooling rate which is greater than the current pulses fall time, thereby setting the spin texture in the magnetic layer.
G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
G11C 11/18 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using Hall-effect devices
H01F 10/32 - Spin-exchange-coupled multilayers, e.g. nanostructured superlattices
H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V. (Germany)
Inventor
Glöggler, Stefan
Korchak, Sergey
Abstract
The present invention relates to improved methods for obtaining purified contrast agents that are suitable for magnetic resonance imaging. The contrast agents are prepared by a method such dynamic nuclear polarization (DNP), hydrogenative parahydrogen induced polarization (PHIP), or Signal Amplification By Reversible Exchange (SABRE). High degrees of purity are achieved by performing an evaporation step to separate a signal enhanced precursor or the contrast agent from a metal catalyst or a source of radicals.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Hackner, Maximilian
Spatz, Joachim
Abstract
The invention relates to a method of assembling a fiber network comprising a plurality of metal fibers, wherein the method comprises the following steps:
The invention relates to a method of assembling a fiber network comprising a plurality of metal fibers, wherein the method comprises the following steps:
providing a loose network out of the plurality of metal fibers at an assembling site; fixing the plurality of metal fibers to one another by forming contact points between the single metal fibers by heating the plurality of fibers at a heating rate higher than 50 K/min, in particular higher than 100 K/min, especially higher than 200 K/min, preferably higher than 1000 K/min, to a fixation temperature selected in the range of 50 to 98% of their melting point temperature; and cooling the plurality of fibers at a cooling rate higher than 50 K/min, preferably higher than 100 K/min. The invention further relates to a network of metal fibers comprising a plurality of metal fibers fixed one to another at contact points, wherein the metal fibers non-round cross section, in particular a rectangular, quadratic, partial circular or an elliptical cross section with a large axis and a small axis, or wherein the metal fibers comprise a round cross section, and wherein the fibers comprise a width which is generally constant along a length of the fiber such that a variation of the width of the fiber along its length is less than 40%, preferably less than 30%, in particular less than 20%.
B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sinteringApparatus specially adapted therefor
B01D 39/10 - Filter screens essentially made of metal
B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires
B22F 1/05 - Metallic powder characterised by the size or surface area of the particles
D04H 1/54 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving
D04H 1/556 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving by infrared heating
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (Germany)
Inventor
Unterauer, Eduard
Grabmayr, Heinrich
Ganji, Mahipal
Hellmeier, Joschka
Baudrexel, Isabelle
Schmied, Jürgen
Strauss, Sebastian
Jungmann, Ralf
Abstract
The present invention relates to a single-stranded nucleic acid molecule, comprising (a) a first nucleic acid sequence being capable of specifically hybridizing to a target complementary nucleic acid sequence, and (b) a second nucleic acid sequence that differs from the first nucleic acid sequence and is capable of transiently binding to a complementary nucleic acid sequence being labeled by an imaging molecule, wherein the first nucleic acid sequence is capable of stronger associating with its complementary nucleic acid sequence than the second nucleic acid sequence.
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Rexer, Thomas F.T.
Mahour, Reza
Abstract
The present invention relates to a method for producing cytidine 5′-monophospho-N-acetyl-neuraminic acid (CMP-Neu5Ac, 1) from low-cost substrates N-acetyl-D-glucosamine (GlcNAc), pyruvate, cytidine and polyphosphate in a single reaction mixture with a set of optionally immobilized or optionally co-immobilized enzymes comprising N-acylglucoamine 2-epimerase (AGE), an N-acetylneuraminate lyase (NAL), an N-acylneuraminate cytidylyltransferase (CSS), a uridine kinase (UDK), a uridine monophosphate kinase and a polyphosphate kinase 3 (PPK3). Further, said process may be adapted to produce Neu5Acylated i.e. sialylated biomolecules and biomolecules including a saccharide, a peptide, a protein, a glycopeptide, a glycoprotein, a glycolipid, a glycan, an antibody, and a glycoconjugate, in particular, an antibody drug conjugate, and a carbohydrate conjugate vaccine, or a flavonoid.
C12P 19/46 - Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V. (Germany)
Inventor
Glöggler, Stefan
Korchak, Sergey
Mamone, Salvatore
Abstract
The present invention relates to a method for transferring a two-spin order of a molecule (e.g. parahydrogen) into a hyperpolarization of at least one heteronucleus, the method comprising the steps of: providing a molecule (e.g. parahydrogen pH2) comprising two protons and at least one heteronucleus (S3, S4), the protons having nuclear spins being coupled to a nuclear spin of the at least one heteronucleus; exposing the protons and the at least one heteronucleus to an e.g. homogeneous magnetic field (B0) in a z-direction, the z-direction forming a right-handed orthogonal coordinate system with an x- and a y-direction; and applying a sequence of radio frequency pulses to the protons and the at least one heteronucleus in order to transfer said two-spin order into the hyperpolarization of the at least one heteronucleus, wherein said sequence of radio frequency pulses comprises a first, a second, and a third group (NA, NB, NC) of 180° radio frequency pulses, wherein the first group (NA) of 180° radio frequency pulses is consecutively applied nA times during a first time interval (τA) and wherein the second group (NB) of 180° radio frequency pulses is consecutively applied nB times during a second time interval (τB) after the last first group, and wherein the third group (NC) of 180° radio frequency pulses is consecutively applied nC times during a third time interval (τC) after the last second group, wherein nA, nB, nC are integer numbers, respectively.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Braun, Wolfgang
Mannhart, Jochen
Faeth, Brendan
Hensling, Felix
Abstract
The invention relates to a method for the controlled deposition of an oxide layer (80) of a target oxide (82) on a substrate (70) in a thermal laser epitaxy (TLE) system (100), the target oxide (82) comprising a defined stoichiometry and being formed from one or more evaporated and/or sublimated source materials and oxygen originating from a gaseous oxidizing agent (54), the TLE system (100) further comprising a reaction chamber (10) and one or more laser sources (20) for providing laser beams (22) within the reaction chamber (10). Further, the invention relates to a TLE system (100) constructed for carrying out said method.
EBERHARD KARLS UNIVERSITÄT TÜBINGEN MEDIZINISCHE FAKULTÄT (Germany)
HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH (Germany)
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V. (Germany)
Inventor
Boudrioua, Abdelhakim
Korotkov, Vadim
Joiner, Joe
Grin, Iwan
Naini, Arun
Kalverkamp, Simon
Kronenberger, Thales
Poso, Antti
Hartmann, Marcus
Brönstrup, Mark
Wagner, Samuel
Coyle, Travis Benjamin
Abstract
The present invention relates to compounds of formula (la) that block invasion-associated pathogenicity of Salmonella Typhimurium by inhibiting the activity of the transcription factor HilD. These compounds are useful in the treatment or prophylaxis of Salmonella infections (salmonellosis).
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
75.
HYBRID POLYMER COMPRISING A POLYSACCHARIDE POLYMER AND PEPTIDE CHAINS
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Gacanin, Jasmina
Wiechmann, Luisa
Synatschke, Christopher
Weil, Tanja
Kayser, Christoph
Lukowicz, Lukas
Petrozziello, Lena
Abstract
The present invention relates to a hybrid polymer comprising a polysaccharide polymer and peptide chains, to blends, hydrogels and formulations comprising the hybrid polymer, and to the use of the hybrid polymer as a rheology modifying agent.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Braun, Wolfgang
Abstract
The present invention relates to an optical element (10) for use with a reaction chamber (70), in particular a reaction chamber (70) of a thermal laser evaporation system, the reaction chamber (70) having a chamber wall (72), with a flange (80) of the reaction chamber (70) being arranged at an opening (74) in the chamber wall (72). Further, the present invention relates to a reaction chamber (70), in particular reaction chamber (70) of a thermal laser evaporation system, comprising a chamber wall (72) enclosing a sealable reaction volume, in particular sealable with respect to the ambient atmosphere, the reaction volume fillable with a reaction atmosphere (90), the reaction chamber (70) further comprising a flange (80) arranged at an opening (74) in the chamber wall (72).
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
CENTER OF PLANT SYSTEMS BIOLOGY AND BIOTECHNOLOGY (Bulgaria)
Inventor
Fernie, Alisdair R.
Zhang, Youjun
Abstract
The present invention relates to the Paclitaxel (taxol) biosynthesis pathway and in particular to methods for producing 4β,20-taxadiene, 10-deacetylbaccatin III, Baccatin III or β-phenylalanoyl-coA as well as corresponding uses. The present invention further relates to a vector, recombinant organism, a tissue, a cell, or an organelle comprising the enzymes being required for the production of 4β,20- taxadiene, 10-deacetylbaccatin III, Baccatin III or β-phenylalanoyl-coA.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Vorholt, Andreas J.
Leitner, Walter
Faßbach, Thiemo
Kossmann, Paul
Abstract
The present invention is directed towards a process for the preparation of free isocyanates, which improves upon the disadvantages associated with heterogeneous catalysis. The process comprises converting formamides into the corresponding isocyanates via a catalytic dehydrogenation, which involves bringing the formamide into contact with a Group VII, VIII or IX transition metal complex and heating.
C07C 263/12 - Preparation of derivatives of isocyanic acid from or via nitrogen analogues of carboxylic acids, e.g. from hydroxamic acids, involving a Hofmann, Curtius or Lossen-type rearrangement
B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Nobach, Holger
Abstract
In a thermal anemometry method of measuring a flow velocity (v) of a flowing fluid (5), a probe (2) is arranged in the flowing fluid (5). An electric current (4) is passed through the probe (2) to heat up the probe (2) to a temperature (Tw) that is higher than an ambient temperature (Ta). An amperage of the electric current (4) through the heated probe (2) and a voltage dropping over the heated probe (2) are measured, while the electric current (4) heating up the probe (2) is passed through the heated probe (2). The flow velocity (v) is determined using the temperature (Tw) and a change in the temperature (dTw/dt) of the heated probe (2), and an electric power (Pw) supplied to the heated probe (2) by the electric current (4), which are all determined from the amperage and the voltage, and a heat capacity (Cw) of the probe (2).
G01P 5/12 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring thermal variables using variation of resistance of a heated conductor
G01P 5/10 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring thermal variables
82.
NANOPOROUS POLYMER MATERIALS AND A FACILE PROCESS FOR THEIR PREPARATION
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Kremer, Kurt
Hsu, Hsiao-Ping
Fytas, Georg
Singh, Manjesh
Abstract
The present invention relates to novel nanoporous polymer materials as well as to a facile, straight forward process for their preparation by fast mechanical deformation of highly entangled polymer articles above the glass transition temperature and subsequent quenching well below the glass transition temperature. The invention further encompasses the use of such nanoporous polymer materials in a broad variety of applications.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Jeschenko, Pascal Max
Spatz, Joachim
Tenbusch, Jan
Möller, Martin
Abstract
The present invention concerns a three-dimensional (3D) network of metal fibers comprising a plurality of metal fibers and a metallic compound, an electrode having said three-dimensional (3D) network of metal fibers, a battery comprising said electrode, a filter having said three-dimensional (3D) network of metal fibers, a catalyst having said three-dimensional (3D) network of metal fibers, and a method of producing a three-dimensional (3D) network of metal fibers by electroless deposition.
B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sinteringApparatus specially adapted therefor
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Braun, Wolfgang
Abstract
The present invention is related to a method of coating a coating region (58) on a front surface (56) of a substrate (50) with a source material (40) thermally evaporated and/or sublimated from a source (30) by electromagnetic radiation (80). Further, the present invention is related to an apparatus (100) for a thermal evaporation system (200) for coating a coating region (58) on a front surface (56) of a substrate (50) with a source material (40) thermally evaporated and/or sublimated by electromagnetic radiation (80) from a source (30).
C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
C23C 16/458 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for supporting substrates in the reaction chamber
C23C 16/48 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating by irradiation, e.g. photolysis, radiolysis, particle radiation
85.
CRYSTALLOGRAPHY OF MICROCRYSTALS USING A DYNAMIC SAMPLE JET CATCHING DEVICE
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Doak, Robert Bruce
Abstract
Disclosed is a system (400) for crystallographic investigation of microscopic crystals, in particular microscopic crystals of biological macromolecules, the system (400) comprising: an extrusion device (410) for extruding through a nozzle (112) a jet (114) of a viscous liquid with microscopic crystals embedded therein in a propagation direction, a chamber (401) for receiving the jet (114) and a beam (406) of electromagnetic radiation irradiating the jet (114), and a catching device (100) with a collector surface (124) for receiving the jet (114) on a contact position of the collector surface (124), wherein, at the contact position, the collector surface (124) is in a translational and / or rotational motion relative to the nozzle (112) in a direction differing from the propagation direction of the jet (114).
G01N 23/20 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using diffraction of the radiation by the materials, e.g. for investigating crystal structureInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materialsInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using reflection of the radiation by the materials
G01N 23/20008 - Constructional details of analysers, e.g. characterised by X-ray source, detector or optical systemAccessories thereforPreparing specimens therefor
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Wang, Chunxiang
Wu, Yingdan
Dong, Xiaoguang
Sitti, Metin
Abstract
The invention relates to a method for probing one or more properties of a material (10) at a probing spot (14) at the surface (12) of the material (10) by an untethered robot (20), the robot (20) comprising a shape changeable member (30) actuatable by temporally and/or spatially variable magnetic fields. Further, the invention relates to a robot for probing one or more properties of a material (10) at a probing spot (14) at the surface (12) of the material (10), wherein the robot (20) is untethered and comprises a shape changeable member (30) actuatable by temporally and/or spatially variable magnetic fields, wherein the robot (20) comprises two footpads (22) arranged at opposite ends of the shape changeable member (30), and the robot (20) further comprises an adhesive probing patch (50) arranged along the shape changeable member (30) between the two footpads (22). Additionally, the invention relates to a system (100) for probing one or more properties of a material (10) at a probing spot (14) at the surface (12) of the material (10), comprising a magnetic actuation system (110), an imaging system (120), a data analyzing system (130), and a robot (20).
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Levin Rojas, Natalia
Goclik, Lisa
Walschus, Henrik
Bordet, Alexis
Leitner, Walter
Abstract
The present invention is directed towards catalysts comprising ionic liquids, their use in decarboxylation reactions and their use in tandem reduction and decarboxylation reactions. A method employing such catalysts to access phenol and aniline derivatives is also claimed. The catalysts and methods of the present invention improve upon the disadvantages associated with literature decarboxylation reactions.
88.
APPARATUS FOR A THERMAL EVAPORATION SYSTEM AND METHOD OF COATING A COATING REGION ON A FRONT SURFACE OF A SUBSTRATE
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Braun, Wolfgang
Abstract
The present invention relates to an apparatus (100) for a thermal evaporation system (200) and to a thermal evaporation system (200), respectively, for coating a coating region (58) on a front surface (56) of a substrate (50) with a source material (40) thermally evaporated and/or sublimated from a source (30) by electromagnetic radiation (80). Further, the present invention relates to a method coating a coating region (58) on a front surface (56) of a substrate (50) with a source material (40) from a source (30) thermally evaporated and/or sublimated by electromagnetic radiation (80).
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V (Germany)
Eberhard Karls Universität Tübingen (Germany)
Inventor
Gross, Christian
Bloch, Immanuel Felix
Abstract
A system for performing quantum operations comprising an optical superlattice and a plurality of optical tweezers, wherein the optical superlattice comprises a plurality of main sites; each main site comprises a storage site and an auxiliary site, each configured to hold an atom; the optical superlattice is configured to merge the storage site and the auxiliary site of each main site; and the plurality of optical tweezers is configured to move atoms provided in the plurality of main site from one main site to another main site.
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (Germany)
Inventor
Bähr, Alexander
Lechner, Peter
Ninkovic, Jelena
Richter, Rainer
Schopper, Florian
Treis, Johannes
Abstract
The invention relates to a DEPFET comprising: a semiconductor substrate (100) of a first conduction type, which has a first main surface (101) and a second main surface (102), which are opposite one another; a source terminal region (1s) of a second conduction type on the first main surface (101); a drain terminal region (1d) of a second conduction type; a channel region (10), which is arranged between the source terminal region (1s) and the drain terminal region (1d); a gate electrode (11), which is separated from the channel region (10) by a gate insulator (6); a rear activation region (104) of a second conduction type, which is formed on the second main surface (102); and a substrate doping increase region (2) of a first conduction type, which is formed at least under the source terminal region (1s) and under the channel region (10), the substrate doping increase region (2) having a signal charge control region (20) of the first conduction type below the gate electrode (11), in which signal charge control region the effective doping dose has a higher value than at other points of the substrate doping increase region (2) below the gate electrode.
H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
H01L 21/265 - Bombardment with wave or particle radiation with high-energy radiation producing ion implantation
H01L 29/10 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions with semiconductor regions connected to an electrode not carrying current to be rectified, amplified, or switched and such electrode being part of a semiconductor device which comprises three or more electrodes
H01L 29/423 - Electrodes characterised by their shape, relative sizes or dispositions not carrying the current to be rectified, amplified or switched
H01L 31/113 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by field-effect operation, e.g. junction field-effect photo- transistor being of the conductor-insulator- semiconductor type, e.g. metal- insulator-semiconductor field-effect transistor
91.
ARTIFICIAL COMPLEX FOR TETHERING CHROMATIDS OR CHROMOSOMES
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Schuh, Melina
Webster, Alexandre
Abstract
During ageing, egg cells display a gradual loss of cohesin complexes. The cohesin loss eventually causes sister chromatids to separate prematurely, which leads to aneuploidy. The inventors engineered an artificial cohesion system, which is a complex for chromatid or chromosome tethering to reduce, for example, age-related premature separation of sister chromatids in eggs. The artificial cohesion system is a complex, which tethers chromosomes or chromatids so that e.g. the risk of aneuploidy is reduced. Said complex comprises (I) one or more first protein(s) and (II) one or more second protein(s), wherein the (I) first and the (II) second protein(s) each comprise (i) a chromatin-binding component, (ii) a protein-binding region being N-terminal of the chromatin-binding component, (Hi) a protein-binding region being C-terminal of the chromatin-binding component. The present invention also includes nucleic acid molecule(s) encoding said complex. Furthermore, several in vitro methods concerning the complex or the nucleic acid molecule(s) encoding said complex also form part of the invention.
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
C12N 15/62 - DNA sequences coding for fusion proteins
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Song, Alexander
Kottapalli, Sai Nikhilesh Murty
Schlieder, Lennart
Volchkov, Valentin
Schölkopf, Bernhard
Fischer, Peer
Abstract
The present invention provides an opto-electronic computing device, comprising one or more computation modules that each comprise: - an input layer comprising an array of photosensors for generating electrical signals based on input optical signals, - an output layer comprising an array of light emitters for generating output optical signals, - electronic circuitry for processing the generating electrical signals to generate driving signals for the array of light emitters, and - an optical layer comprising an array of optical elements for modifying the optical signals, characterized in that the device comprises one or more connection elements that pass the electrical signals from the input layer to the output board and that are oriented perpendicular to a plane of the input board.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V. (Germany)
GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN (Germany)
Inventor
Ropers, Claus
Feist, Armin
Otto, Johannes
Horstmann, Jan Gerrit
Vogelgesang, Simon
Abstract
An electron microscopy apparatus (100) for time resolved low energy electron microscopy investigation of a sample (1) comprises a tip-shaped photo-emitter source (11), which is arranged for radiation-induced emission of source electrons (2) towards the sample (1), a radiation source device (20) for creating emitter excitation radiation (3) with an emitter excitation waveform and for irradiating the photo-emitter source (11) with the emitter excitation radiation (3), a sample excitation device (30) for applying a sample excitation (4) to the sample (1), and a detector device (40) for collecting sample electrons emerging at the sample (1) in response to an interaction of the source electrons (2) with the sample (1), wherein the electron microscopy apparatus (100) is configured for the time-resolved investigation of the sample (1) based on a synchronization of the sample excitation (4) applied to the sample (1) with the source electrons (2) received by the sample (1), and wherein the photo-emitter source (11) is configured for creating the source electrons (2) in response to the irradiation with the emitter excitation radiation (3) by an emission process in which the number of emitted electrons is linear with respect to the irradiated power of the emitter excitation radiation (3) on the photo- emitter source (11). Furthermore, an electron microscopy method of investigating a sample (1) by time resolved low energy electron microscopy is described.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Lindner-Mehlich, Steffen Nikolaus
Krüsemann, Jan Lukas
Mavrothalassiti, Eleni
Schulz-Mirbach, Helena Anna Maria
Andreadaki, Theofania Pagona
Abstract
nuoA, nuoB, nuoC, nuoD,nuoE, nuoF, nuoG, nuoH, nuoI, nuoJ, nuoK, nuoL, nuoMnuoNnuoN; wherein the genetically engineered bacterium is able of oxygen uptake, i.e. the genetically engineered bacterium is able to use oxygen as electron acceptor, and wherein the bacteria is genetically engineered to produce a fermentation product in presence of oxygen. In particular, the present invention provides bacteria genetically engineered to produce lactate from glycerol or from glucose in presence of oxygen. The present invention further provides bacteria genetically engineered to produce isobutanol and/or ethanol from glycerol in presence of oxygen. Further described is a method for producing a fermentation product using the disclosed genetically engineered bacteria.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
CEMM – FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (Austria)
Inventor
Waldmann, Herbert
Xue, Gang
Xie, Jianing
Winter, Georg
Hinterndorfer, Matthias
Abstract
The present invention relates to compounds of the formula (I) as bifunctional protein targeting chimeras (PROTACs), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. These compounds, pharmaceutically acceptable salts, and pharmaceutical compositions thereof are useful in the treatment or prophylaxis of a cancer, an autoimmune disease, or an inflammatory disease, in paticular, associated with and/or caused by PDEdelta (PDEδ) / K-Ras or B lymphoid kinase (BLK) /Bruton´s tyrosine kinase (BTK) or cyclin-dependent kinase 9 (CDK9).
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Spitschan, Manuel
Teufel, Harald
Walzog, Joshi
Abstract
Disclosed is a system for the measurement and analysis of melanopic light quantity, comprising a wearable sensor device (100), comprising a sensor array (102), the sensor array (102) comprising sensors, the sensors comprising a melanopic light sensor and at least one of a UV light sensor and an accelerometer. A data processing unit determines a behavioral pattern comprising analyzing the time-series sensor data. If further determines a melanopic light quantity within a predefined time range of the sensor data of the melanopic light sensor, determines a behavioral element of the pattern which has assigned a respective one of the melanopic light quantities suitable to at least partially compensate for the difference between a desired value and the determined value of the melanopic light quantity, and outputs a signal comprising a behavioral recommendation based on the selected behavioral element.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
MYRIA BIOSCIENCES AG (Switzerland)
Inventor
Bode, Helge B.
Abbood, Nadya
Bozhüyük, Kenan
Abstract
[1] The invention is based on newly derivatized protein interaction adaptor protein sequences based on SYNZIP protein domains. The improved SYNZIP domain variants of the invention were designed to be suitable for interconnecting domains of non-ribosomal peptide synthetases (NRPS) or domains of polyketide synthases (PKS), such as for generating NRPS- PKS hybrid complexes. The invention provides the SYNZIP derivative sequences, NRPS domains containing them, NRPS domain libraries thereof, as well as methods for the production and use in peptide design, screening and production.
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (Germany)
Inventor
Balouchev, Stanislav
Landfester, Katharina
Abstract
The invention relates to a sensor support (104, 1600) for a beehive panel (100, 300, 400, 500, 600, 700, 800, 954), the sensor support comprising a plurality of temperature sensors (204, 1602), the sensor support having an eigen frequency of 15 Hz – 300 Hz.
G01K 1/14 - SupportsFastening devicesArrangements for mounting thermometers in particular locations
G01K 1/02 - Means for indicating or recording specially adapted for thermometers
A01K 47/02 - Construction or arrangement of frames for honeycombs
A01K 47/06 - Other details of beehives, e.g. ventilating devices, entrances to hives, guards, partitions or bee escapes
G01K 7/22 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements the element being a non-linear resistance, e.g. thermistor
99.
3-SUBSTITUTED 1H-PYRROLO[2,3-B]PYRIDINE AS GRK5 MODULATORS
The present invention relates to certain 3-substituted 1 H-pyrrolo[2,3-b]pyridine compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment or prevention of a disease or medical condition mediated through GRK5 selected from heart disease, inflammatory and immunological disease, metabolic disease and cancer.
The present invention relates to certain 3-substituted 1 H-pyrrolo[2,3-b]pyridine compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment or prevention of a disease or medical condition mediated through GRK5 selected from heart disease, inflammatory and immunological disease, metabolic disease and cancer.
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/4453 - Non-condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61P 9/00 - Drugs for disorders of the cardiovascular system
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
100.
ANTISENSE-OLIGONUCLEOTIDES FOR PREVENTION OF KIDNEY DYSFUNCTION PROMOTED BY ENDOTHELIAL DYSFUNCTION BY EPHRIN-B2 SUPPRESSION
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (Germany)
Inventor
Nakayama, Masanori
Hikita, Takao
Abstract
The present invention relates to antisense-oligonucleotides capable of hybridizing with a region of the gene encoding Efnb2, or with a region of the mRNA encoding Efnb2, and salts and optical isomers of said antisense-oligonucleotides for use in prevention of kidney dysfunction promoted by endothelial dysfunction.