A microbiota improving agent for improving mucosal (except the skin) microbiota and containing at least one substance (X) selected from the group consisting of compounds (X1) having two or more hydroxy groups included in an oxoacid group, and salts thereof, wherein the number average molecular weight of the substance (X) is 560 or more.
The present invention addresses the problem of providing an oral care food which can sufficiently suppress the proliferation and hyphal formation of Candida and has a bacterial flora-improving effect. The present invention relates to an oral care food which contains a substance (X) that comprises at least one substance selected from the group consisting of a compound (X1) having two or more hydroxy groups contained in an oxo acid group and salts of the compound (X1), wherein the proportion of the sum of the mass of the oxo acid group in the compound (X1), the mass of hydroxy groups that are not contained in the oxo acid group, the mass of carbonyl groups that are not contained in the oxo acid group, the mass of carbon atoms that are contained in an imidazole skeleton and a pyridine skeleton, and the mass of nitrogen atoms that are contained in the imidazole skeleton and the pyridine skeleton is 45 mass% or more with respect to the molecular weight of the compound (X1), the molecular weight of the substance (X) is 550 or less, the pH of an aqueous solution containing the oral care food in an amount of 1 wt% is 6-8, and the oral care food has a solid form at 25°C.
The present invention aims to provide a microbiota improving agent for improving at least one of mucosal microbiota, skin microbiota, or nail microbiota, the microbiota improving agent exhibiting a high pathogenic bacteria inhibitory effect while maintaining resident non-pathogenic bacteria, thus persistently improving the microbiota balance. The present invention relates to a microbiota improving agent for improving at least one of mucosal microbiota, skin microbiota, or nail microbiota, the microbiota improving agent containing: a substance (X); and a base (Y) containing a non-volatile component, the substance (X) including at least one selected from the group consisting of a compound (X1) having two or more hydroxy groups contained in at least one oxoacid group and a salt of the compound (X1), a compound (X2) having one hydroxy group contained in an oxoacid group and a salt of the compound (X2), a heterocyclic compound (X3) having no oxoacid group and a salt of the compound (X3), and a ketone (X4) having no oxoacid group. In the compound (X1), a total mass percentage of the at least one oxoacid group, a hydroxy group not contained in the oxoacid group, a carbonyl group not contained in the oxoacid group, carbon atoms contained in an imidazole skeleton and a pyridine skeleton, and nitrogen atoms contained in the imidazole skeleton and the pyridine skeleton is 45% by mass or more based on a molecular weight of the compound (X1). The compound (X2) has an atom having an unshared electron pair, the atom excluding atoms contained in the oxoacid group and atoms contained in an amino group not constituting an imidazole skeleton and in an amino group not constituting a pyridine skeleton. In the compound (X2), a total mass percentage of the oxoacid group, a hydroxy group not contained in the oxoacid group, a carbonyl group not contained in the oxoacid group, carbon atoms contained in an imidazole skeleton and a pyridine skeleton, and nitrogen atoms contained in the imidazole skeleton and the pyridine skeleton is 55% by mass or more based on a molecular weight of the compound (X2). The heterocyclic compound (X3) has an imidazole skeleton or a pyridine skeleton and at least one of a hydroxy group or a carbonyl group, or has two or more skeletons selected from the group consisting of an imidazole skeleton and a pyridine skeleton. The ketone (X4) has a linear β-diketone structure. The substance (X) has a molecular weight of 550 or less. The non-volatile component has an HLB value of 7 or more. The microbiota improving agent satisfies the following conditions (i) and (ii): (i) the microbiota improving agent has a worked penetration of 100 to 400 as measured in accordance with JIS K 2220; and (ii) the microbiota improving agent has a viscosity at 37° C. of 1 to 4,000 Pa·s as measured with a cone-and-plate rheometer.
A61K 31/7012 - Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
A61K 33/14 - Alkali metal chloridesAlkaline earth metal chlorides
The purpose of the present invention is to provide a microbiota improving agent that is for improving the microbiota in mucosa, skin, and/or nails, that is highly effective in suppressing pathogenic microbes while retaining non-pathogenic indigenous microbes, and that can improve balance in the microbiota in a sustained manner. The present invention pertains to a microbiota improving agent that is for improving the microbiota in mucosa, skin, and/or nails, that contains a base agent (Y) containing a nonvolatile component and at least one substance (X) selected from the group consisting of compounds (X1) having two or more hydroxy groups included in an oxo acid group and salts of said compounds, compounds (X2) having one hydroxy group included in an oxo acid group and salts of said compounds, heterocyclic compounds (X3) not having an oxo acid group and salts of said compounds, and ketones (X4) not having an oxo acid group and salts of said ketones, that satisfies conditions (i) and (ii), and in which the HLB value of the nonvolatile component is 7 or more. (i) The worked penetration of the microbiota improving agent as measured in accordance with JIS K 2220 is 100-400. (ii) The viscosity of the microbiota improving agent at 37°C measured using a cone-plate type rotational viscometer is 1-4,000Pa·s.
A23L 29/206 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of vegetable origin
A23L 29/269 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
A23L 29/288 - Synthetic resins, e.g. polyvinylpyrrolidone
A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
A61K 8/19 - Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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