Abstract

The present invention relates to compositions and methods of wound debridement and stimulation of granulation tissue formation, thereby preparing the wound bed to facilitate and promote the process of wound healing. In particular, the present invention relates to methods of debridement of chronic wounds by topically applying to a wound site or bed a composition containing a proteolytic enzyme mixture obtained from bromelain and a water-soluble gelling agent, the composition being applied to the wound site or bed up to ten times over a period of up to four weeks, resulting in a clean wound bed covered with granulation tissue prepared towards wound healing.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 9/06 - OintmentsBases therefor
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

The present invention provides methods of treating cutaneous manifestations of psoriasis comprising topically applying to an affected skin area of a subject a pharmaceutical composition comprising a partially purified proteolytic enzyme mixture obtained from crude bromelain and a pharmaceutically acceptable carrier, thereby treating the cutaneous manifestations of psoriasis.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/02 - Inorganic compounds
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61P 17/06 - Antipsoriatics

Abstract

The present invention provides methods for treating skin cancers utilizing pharmaceutical formulations in the form of a hydrogel that includes a proteolytic enzyme mixture obtained from bromelain and a water-soluble gelling agent. In particular, the method is useful for treating non-melanoma skin cancers, pre-cancerous skin lesions, and benign skin lesions.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/06 - OintmentsBases therefor
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/02 - Inorganic compounds
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61P 35/00 - Antineoplastic agents
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

The present invention provides methods of treating cutaneous manifestations of psoriasis comprising topically applying to an affected skin area of a subject a pharmaceutical composition comprising a partially purified proteolytic enzyme mixture obtained from crude bromelain and a pharmaceutically acceptable carrier, thereby treating the cutaneous manifestations of psoriasis.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61P 17/00 - Drugs for dermatological disorders
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• A61K 9/06 - OintmentsBases therefor
• A61K 8/66 - Enzymes
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

The present invention provides pharmaceutical formulations in the form of a hydrogel which comprise a proteolytic enzyme mixture obtained from bromelain and a water-soluble gelling agent, for use in treating non-melanoma skin cancers, pre-cancerous skin lesions, and benign skin lesions.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/726 - Glycosaminoglycans, i.e. mucopolysaccharides
• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 38/54 - Mixtures of enzymes or proenzymes covered by more than a single one of groups or
• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages

Abstract

The present invention provides pharmaceutical formulations in the form of a hydrogel which comprise a proteolytic enzyme mixture obtained from bromelain and a water-soluble gelling agent, for use in treating non-melanoma skin cancers, pre-cancerous skin lesions, and benign skin lesions.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 31/726 - Glycosaminoglycans, i.e. mucopolysaccharides
• A61K 38/54 - Mixtures of enzymes or proenzymes covered by more than a single one of groups or
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages

Goods & Services

Pharmaceutical drug preparations and products, namely, an enzyme used in treatment of burns and wounds.

Goods & Services

(1) Pharmaceutical drug preparations and products, namely, an enzyme used in treatment of burns and wounds.

Goods & Services

Pharmaceutical drug preparations and products, namely, an enzyme used in treatment of burns and wounds

Abstract

Methods for wound debridement and specifically methods of debridement of chronic wounds. These methods provide topically applying to a wound site a debriding formulation in the form of a hydrogel that includes a proteolytic enzyme mixture obtained from bromelain and a water-soluble gelling agent, with the debriding formulation being applied to the wound site up to ten times over a period of up to four weeks, thereby achieving debridement of chronic wounds.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

The present invention relates to debriding compositions in the form of an aqueous gel. Particularly, the present invention relates to a debriding composition comprising a proteolytic enzyme mixture obtained from bromelain present in a dry form, and an aqueous gel carrier, wherein, prior to use, the proteolytic enzyme mixture being admixed with the aqueous gel carrier to form a debriding composition useful for debridement and treatment of c wounds.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 9/06 - OintmentsBases therefor
• A61K 38/54 - Mixtures of enzymes or proenzymes covered by more than a single one of groups or
• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin
• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• A61K 47/02 - Inorganic compounds
• C12N 9/50 - Proteinases

Abstract

The present invention relates to methods of wound debridement. Particularly, the present invention relates to methods of debridement of chronic wounds comprising topically applying to a wound site a debriding formulation in the form of a hydrogel comprising a proteolytic enzyme mixture obtained from bromelain and a water-soluble gelling agent, the debriding formulation being applied to the wound site up to ten times over a period of up to four weeks, thereby achieving debridement of chronic wounds.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
• A61P 17/00 - Drugs for dermatological disorders
• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin

Abstract

The present invention relates to methods of wound debridement. Particularly, the present invention relates to methods of debridement of chronic wounds comprising topically applying to a wound site a debriding formulation in the form of a hydrogel comprising a proteolytic enzyme mixture obtained from bromelain and a water-soluble gelling agent, the debriding formulation being applied to the wound site up to ten times over a period of up to four weeks, thereby achieving debridement of chronic wounds.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
• A61P 17/00 - Drugs for dermatological disorders
• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin

Goods & Services

Pharmaceutical drug preparations and products, namely, an enzyme used for the treatment of burns and wounds

Abstract

The present invention relates to debriding compositions in the form of an aqueous gel. Particularly, the present invention relates to a debriding composition comprising a proteolytic enzyme mixture obtained from bromelain present in a dry form, and an aqueous gel carrier, wherein, prior to use, the proteolytic enzyme mixture being admixed with the aqueous gel carrier to form a debriding composition useful for debridement and treatment of c wounds.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin

Abstract

The present invention relates to debriding compositions in the form of an aqueous gel. Particularly, the present invention relates to a debriding composition comprising a proteolytic enzyme mixture obtained from bromelain present in a dry form, and an aqueous gel carrier, wherein, prior to use, the proteolytic enzyme mixture being admixed with the aqueous gel carrier to form a debriding composition useful for debridement and treatment of c wounds.

IPC Classes  ?

• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin
• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Goods & Services

(1) Pharmaceutical drug preparations and topically applied gel products, namely, an enzyme used in treatment of burns and wounds.

Goods & Services

(1) Pharmaceutical drug preparations and topically applied gel products, namely, an enzyme used in treatment of burns and wounds.

Abstract

The present invention relates to a proteolytic extract obtained from bromelain for the treatment of connective tissue diseases. In particular, the present invention relates to a pharmaceutical composition comprising a proteolytic extract obtained from bromelain for the treatment of diseases such as Dupuytren's disease and Peyronie's disease.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/08 - Solutions
• A61K 9/14 - Particulate form, e.g. powders
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 36/88 - Liliopsida (monocotyledons)

Abstract

The present invention relates to a proteolytic extract obtained from bromelain for the treatment of connective tissue diseases. In particular, the present invention relates to a pharmaceutical composition that includes proteolytic extract obtained from bromelain for the treatment of diseases such as Dupuytren's disease and Peyronie's disease.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 38/43 - EnzymesProenzymesDerivatives thereof
• A61K 135/00 - Containing or obtained from stems, stalks, branches, twigs or shoots
• A61K 36/88 - Liliopsida (monocotyledons)
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present invention relates to a proteolytic extract obtained from bromelain for the treatment of connective tissue diseases. In particular, the present invention relates to a pharmaceutical composition comprising a proteolytic extract obtained from bromelain for the treatment of diseases such as Dupuytren's disease and Peyronie's disease.

IPC Classes  ?

• A61K 36/88 - Liliopsida (monocotyledons)
• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 19/04 - Drugs for skeletal disorders for non-specific disorders of the connective tissue

Abstract

The present invention relates to a proteolytic extract obtained from bromelain for the treatment of connective tissue diseases. In particular, the present invention relates to a pharmaceutical composition comprising a proteolytic extract obtained from bromelain for the treatment of diseases such as Dupuytren's disease and Peyronie's disease.

IPC Classes  ?

• A61K 36/88 - Liliopsida (monocotyledons)
• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 19/04 - Drugs for skeletal disorders for non-specific disorders of the connective tissue

Goods & Services

Pharmaceutical drug preparations and products, namely, an enzyme used for the treatment of burns and wounds; all included in this class.

Goods & Services

Pharmaceutical drug preparations and products, namely an enzyme used for the treatment of burns and wounds; all included in this class.

Goods & Services

Pharmaceutical drug preparations and products, namely an enzyme used for the treatment of burns and wounds; all included in this class

Abstract

The present invention relates to a debriding composition obtained from bromelain and to methods of producing same. Particularly, the present invention relates to a debriding composition obtained from bromelain comprising proteolytic enzymes having molecular weights of about 23 kDa, being essentially devoid of bromelain inhibitors, and to pharmaceutical compositions comprising same. The debriding compositions and the pharmaceutical compositions comprising same are particularly useful in debriding eschar tissues and in wound healing.

IPC Classes  ?

• A61K 38/54 - Mixtures of enzymes or proenzymes covered by more than a single one of groups or

Goods & Services

(1) Pharmaceutical preparations, namely for treating wounds; plasters for medical use, materials for medical dressings; medical disinfectants for use on a patient.

Goods & Services

Pharmaceutical preparations for treatment of burns and wounds; medical plasters; medical and surgical dressings; medical disinfectants [ Medical apparatus and instruments for the treatment of burns and wounds ]

Goods & Services

Pharmaceutical preparations for treatment of burns and wounds; medical plasters; medical and surgical dressings; medical disinfectants [ Medical apparatus and instruments for the treatment of burns and wounds ]

Goods & Services

Pharmaceutical, veterinary and sanitary preparations; dietetic substances adapted for medical use, food for babies, plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Medical apparatus and instruments. Medical services.

Goods & Services

Pharmaceutical and sanitary preparations not for dental purposes or for use in the field of dentistry; veterinary preparations; dietetic substances adapted for medical use not for dental purposes or for use in the field of dentistry; food for babies, plasters not for dental purposes or for use in the field of dentistry; materials for dressing not for dental purposes or for use in the fields of dentistry; disinfectants not for dental purposes or for use in the field of dentistry; preparations for destroying vermin not for dental purposes or for use in the field of dentistry; fungicides not for dental purposes or for use in the field of dentistry;  herbicides. Medical apparatus and instruments not for dental purposes. Medical services.

Abstract

The present invention relates to a debriding composition obtained from
bromelain and to methods of producing same. Particularly, the present
invention relates to a debriding composition obtained from bromelain
comprising proteolytic enzymes having molecular weights of about 23 kDa, being
essentially devoid of bromelain inhibitors, and to pharmaceutical compositions
comprising same. The debriding compositions and the pharmaceutical
compositions comprising same are particularly useful in debriding eschar
tissues and in wound healing.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Goods & Services

Pharmaceutical, veterinary and sanitary preparations; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.