Shochu [Japanese distilled spirits]; gin; gin cocktails;
western liquors in general; alcoholic fruit beverages;
Japanese shochu-based beverages [chuhai]; Chinese liquors in
general; flavored tonic liquors.
4.
YATSU BOSHI YATSUSHIRO DISTILLERY, KUMAMOTO, JAPAN PRECIOUS CITRUS GIN
Shochu being Japanese distilled spirits; gin; gin cocktails; western liquors in general; alcoholic fruit beverages; Japanese shochu-based beverages in the nature of chuhai; Chinese liquors in general; flavored tonic liquors
Sake; shochu [Japanese distilled spirits]; sake substitutes;
Japanese sweet rice-based mixed liquor (shiro-zake); naoshi
[Japanese liquor]; Japanese shochu-based mixed liquor
[mirin]; Western liquors in general; alcoholic fruit
beverages; fruit wines; wines; Japanese shochu-based
beverages [chuhai]; Chinese liquors in general; flavored
tonic liquors.
6.
CONCENTRATED GRAPE JUICE WITH RICH FLAVOR, AND PRODUCTION METHOD THEREFOR
In the present invention, disclosed is a method for producing a grape juice for which a muscat aroma is emphasized. The method comprises, from among the following steps, a step (a) and a step (b), or step (a), step (b), and a step (c). (a) A step for obtaining skin or a juice which contains skin by crushing grapes and extracting juice from the same. (b) A step for heating a product obtained by adding water to the skin obtained in step (a) or heating the juice which includes the skin, and bringing the same to a temperature of 45-95˚C. (c) A step for, after cooling the mixture obtained in step (b), adding to the mixture an enzyme having glycosidase activity with respect to diglycoside. By using the grape juice produced by this method as a starting material, a wine having a rich muscat aroma can be produced.
The present invention provides a method for producing a fruit wine exhibiting an enhanced muscat flavor, said method including step (a) and step (d), and step (b) and/or step (c), said steps being as follows: (a) a step in which grapes are crushed and juiced to obtain a fruit juice or a fruit-skin-containing fruit juice; (b) a step in which the fruit juice or the fruit-skin-containing fruit juice obtained in step (a) is heated until the temperature thereof reaches a temperature in the range 45-95˚C; (c) a step in which an enzyme exhibiting glycosidase activity is added to the fruit juice or the fruit-skin-containing fruit juice obtained in step (a), when the fruit-juice temperature is in the range 10-55˚C; and (d) a step in which yeast exhibiting β-glucosidase activity is used to ferment the fruit juice obtained in step (b) or step (c). Fruit wine produced using this method exhibits a pleasant muscat flavour.
Provided are a cosmetic product, a pharmaceutical composition, and a food product having a strong skin quality-improving effect, in which the starting material is a natural material. The cosmetic product composition, pharmaceutical composition, and food product for improving skin quality comprise black current fruit as an active ingredient, particularly a polysaccharide that is contained in black current fruit juice and is obtained by enzymatic limited partial decomposition.
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
A61P 17/16 - Emollients or protectives, e.g. against radiation
An iron adsorption or absorption agent with an active ingredient that is a yeast treated with alcohol is used to address the need to provide an iron adsorption or absorption agent which can be used to remove iron content when producing beverages such as fruit juice beverages or alcoholic beverages, and to provide a method of using an iron adsorption or absorption agent to effectively remove iron content from a production starting material solution in situations such as the production process of fruit juice beverages, alcoholic beverages, etc. Moreover, the present invention includes a method of removing iron content from a solution by utilizing said iron adsorption or absorption agent and bringing said iron adsorption or absorption agent into contact with the solution containing iron. Said method is applicable to the manufacture of fruit juice beverages, alcoholic beverages, etc, and does not influence the original taste, etc, of the products. Moreover, the method is inexpensive and makes it possible to remove deleterious iron content from products.
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
A23L 2/02 - Non-alcoholic beveragesDry compositions or concentrates thereforPreparation or treatment thereof containing fruit or vegetable juices
C12G 3/00 - Preparation of other alcoholic beverages
C12G 3/02 - Preparation of other alcoholic beverages by fermentation
C12H 1/02 - Pasteurisation, sterilisation, preservation, purification, clarification, or ageing of alcoholic beverages combined with removal of precipitate or added materials, e.g. adsorption material
13.
METHOD FOR PRODUCING CRYSTALS OF VITAMIN D DERIVATIVE
Provided is a method for producing crystals of a vitamin D derivative represented by formula (I), with which the production can be performed economically in a shorter time than the conventional methods. A crude material of the vitamin D derivative represented by formula (I) is dissolved at room temperature in a carboxylic acid (acetic acid or propionic acid), wherein 10 to 50 ml of the carboxylic acid is used per gram of the crude material, and further an appropriate poor solvent (a hydrocarbon or water) is added thereto, thereby depositing crystals of the vitamin D derivative. Subsequently, the deposited crystals are filtered off and dried, thereby obtaining high-purity crystals of the vitamin D derivative. The target crystals can be obtained in high yield in a shorter time than the conventional methods.
C07C 401/00 - Irradiation products of cholesterol or its derivativesVitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
A61K 31/593 - 9,10-Secocholestane derivatives, e.g. cholecalciferol, vitamin D3
A61P 5/14 - Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
14.
SOFT DRINK, GRAPE PERICARP EXTRACT AND METHODS FOR PRODUCING SAME
Provided are a grape pericarp extract which is rich in 3-mercaptohexan-1-ol precursors having excellent aroma properties; a method for producing the same; a soft drink having a fruity smell and giving a preferable fruity aftertaste after swallowing; and a method for producing a soft drink using the aforesaid grape pericarp extract.
Disclosed are: an alcohol-containing solution which abundantly contains 3-mercaptohexan-1-ol (3MH) that has excellent aromaticity; a process for producing the solution; a flavoring agent comprising an alcohol-containing solution that contains 3MH abundantly; and a process for producing a beverage having improved flavor. Specifically disclosed are: a process for producing a solution containing 3MH and an alcohol, which comprises a step of inoculating a lactic acid bacterium and yeast to an aqueous raw material solution containing S-(3-hexan-1-ol)glutathione and S-(3-hexan-1-ol)-L-cysteine to produce 3MH and the alcohol, wherein the aqueous raw material solution is a solution containing a grape skin extract, the lactic acid bacterium is one capable of converting S-(3-hexan-1-ol)glutathione to S-(3-hexan-1-ol)-L-cysteine, and fermentation is carried out for 0 to 6 days after the inoculation of the lactic acid bacterium to the aqueous raw material solution and subsequently yeast is inoculated to the aqueous solution to carry out alcohol fermentation; a process for producing a beverage having an increased 3MH content, which comprises a step of mixing a solution containing 3MH and an alcohol produced by the process with a beverage; and a process for producing a fruit liquor using a grape skin extract as a raw material.
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (Japan)
Inventor
Fujii Yoshikazu
Fujii Tadashi
Arisawa Akira
Tamura Tomohiro
Abstract
An expression vector capable of expressing a foreign gene in Pseudonocardia autotrophica; a transformant of Pseudonocardia autotrophica produced by using the expression vector; a method for producing a protein by using the transformant; a method for producing an active form of vitamin D3 from vitamin D3, which comprises highly expressing a gene encoding an enzyme involved in the synthesis of the active form of vitamin D3 in a transformant by using the expression vector or the transformant; a method for producing 25-hydroxyvitamin D2 from vitamin D2; and a method for producing pravastatin from compactin, which comprises highly expressing a compactin hydroxylase gene in a transformant by using the expression vector or the transformant.
An outer box for housing an inner bag for a bag-in-box having a spout, comprising a strip body portion formed to have a front plate constituted to permit the attaching of a spout, a back plate and side plates coupling the front and back plates, a pair of inner flaps and a pair of outer flaps for forming an upper lid, and a pair of inner flaps and a pair of outer flaps for forming a bottom lid, wherein the outer box is provided with notched corners on the front side and the bottom lid side of a pair of the side plates and constituted to facilitate an operation for tilting the entire box to the front side by forming a slope on the bottom lid side of the front plate while a bending junction piece is interposed at a position on the bottom lid side where the front plate and an inner flap for the bottom lid are connected. Consequently, liquid still left in the inner bag for a bag-in-box after pouring can be reduced drastically although the reducing could not be attained easily in the prior art.
The nucleotide sequence for DNA involved in the biosynthesis of herboxidiene is determined. By using the DNA, it becomes possible to produce herboxidiene and analogues thereof with high efficiency.
C07D 407/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07K 14/36 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from ActinomycesPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Streptomyces (G)
C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
C12P 17/06 - Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
Disclosed is a method for hydrogenating camptothecin in the presence of a nickel catalyst within a non-reactive solvent. This allows for camptothecin to be selectively hydrogenated efficiently using a low-cost catalyst.
C07D 491/22 - Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or in which the condensed system contains four or more hetero rings
Disclosed is a grape sap containing a large amount of resveratrol (3,5,4-trihydroxystilbene) whose many physiological activities and effects are known. A grape sap containing a large amount of resveratrol is produced by irradiating a branch of a grape tree with a proper dose of ultraviolet ray for a short period with an ultraviolet ray lamp or the like, and subsequently pruning the branch of the grape tree. The grape sap containing a large amount of resveratrol thus produced can be used as a raw material for a cosmetic, or can be used in a cosmetic without any modification.
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
A process for producing a 12-membered-ring macrolide compound which is expected to be a preventive or therapeutic agent for solid tumors, etc. Also provided is an intermediate for the compound. The process comprises acetalizing the 6- and 7-position hydroxy groups of a raw-material 12-membered-ring macrolide compound with a dialkyltin(IV) oxide and then reacting the resultant compound with a carbamoyl halide derivative. Thus, a target 7-position urethane derivative of the 12-membered-ring macrolide compound is efficiently produced without the need of protecting the hydroxy groups in the other positions.
C07D 407/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 295/18 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
Disclosed is a means for improving the poor conversion efficiency in a bioconversion system using an E. coli cell having a bacterium-derived cytochrome P-450 gene integrated therein. A recombinant E. coli cell is produced by integrating genes aciB and aciB both encoding an electron transfer system derived from Acinetobacter sp. strain OC4 into an E coli cell, and adding a polynucleotide encoding an N-terminal sequence composed of 48 amino acid residues of AciA to the 5'-terminus of a bacterium-derived cytochrome P-450 gene, wherein AciA is an alkane-oxidized cytochrome P-450 derived from Acinetobacter sp. strain OC4. By using the recombinant E. coli cell in bioconversion, it becomes possible to convert a hydrophobic or amphipathic substrate compound into a desired compound with extremely high efficiency.
C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
C12P 1/00 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes
24.
TRANSFORMED STRAIN DERIVED FROM STRAIN DEFICIENT IN MULTIDRUG EFFLUX PROTEIN, AND BIOCONVERSION METHOD USING THE SAME
Disclosed is a means for improving the poor conversion efficiency in a conventional bioconversion using a transformant having a gene derived from a heterogeneous organism integrated therein. A microorganism having the deletion of a gene encoding a multidrug efflux protein is used as a host to produce a transformant having a gene derived from a heterogeneous organism integrated therein. By using the transformant in bioconversion, it becomes possible to convert a hydrophobic or amphipathic substrate compound into a desired compound with extremely high efficiency. When an E. coli cell is used as a host, the gene encoding multidrug efflux protein to be deleted may be tolC, acrA, acrB or the like.
Disclosed are: isolated, pure DNA comprising at least one domain encoding a polypeptide associated with the hydroxylation of vitamin D; a polypeptide encoded by the DNA; a autonomously or integratively replicating recombinant plasmid carrying the DNA; a transformant having the DNA; and a method for producing a hydroxylated vitamin D derivative, which is characterized by culturing the transformant in a culture medium and collecting the hydroxylated vitamin D derivative from the culture.
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Disclosed are: a solid of a compound represented by the formula (I), which is homogeneous and highly pure to such an extent that it can be used as an original drug for the preparation of a pharmaceutical product and has good workability; a method for producing the solid; and a pharmaceutical composition comprising the solid. A solid of (8E,12E,14E)-7-[(4- cycloheptylpiperazin-1-yl)-carbonyl]oxy-3,6,16,21- tetrahydroxy-6,10,12,16,20-pentamethyl-18,19-epoxytricosa- 8,12,14-trien-11-olide is found, which has a homogenized specification and good workability.
C07D 407/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
CERAMIDE SYNTHESIS ACCELERATORS, COSMETIC PREPARATION, SKIN PREPARATION FOR EXTERNAL USE, METHOD OF PREVENTING AGING, AND METHOD OF DIMINISHING WRINKLE
A ceramide synthesis accelerator containing the sap of grapevines as an active ingredient; a ceramide synthesis accelerator containing the sap of grapevines and serine as active ingredients; a cosmetic preparation and a skin preparation for external use which each contains either of these ceramide synthesis accelerators; and a method of using these. Thus, a means of safely and effectively improving the barrier function of the skin is provided.
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
A61K 8/44 - Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfurSalts, esters or N-acylated derivatives thereof
A cyclovitamin D derivative produced from 25-hydroxyvitamin D is reacted with osmium tetraoxide or a permanganic acid salt to produce a 10,19-diolcyclovitamin D derivative. The 10,19-diolcyclovitamin D derivative is reacted with a perhalogenic acid salt or lead tetraacetate to produce a 10-oxocyclovitamin D derivative. A 1-hydroxycyclovitamin D derivative is produced from the 10-oxocyclovitamin D derivative via a cyclovitamin D derivative and a 1,10-olefincyclovitamin D derivative. The 1-hydroxycyclovitamin D derivative is subjected to solvolysis, thereby producing a 1-hydroxy-19-norvitamin D derivative. Thus, provided are: a novel process for producing a 1-hydroxy-19-norvitamin D derivative which can be used as an intermediate for the synthesis of a 1-hydroxy-19-norvitamin D derivative which is useful as a pharmaceutical agent; and an intermediate for the production.
C07C 401/00 - Irradiation products of cholesterol or its derivativesVitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
A61K 31/59 - Compounds containing 9,10-seco-cyclopenta[a]hydro- phenanthrene ring systems
National Institute of Advanced Industrial Science and Technology (Japan)
Inventor
Fujii, Yoshikazu
Tamura, Tomohiro
Abstract
A vitamin D3 hydroxylase is purified from a cultured Pseudonocardia autotrophica cell, and a primer is designed based on the information on amino acid sequence for the hydroxylase. Subsequently, PCR is conducted using genomic DNA of Pseudonocardia autotrophica as a template to clone a gene for the vitamin D3 hydroxylase. By conducting a conversion reaction using a microorganism in which the gene is expressed using a proper expression system, a hydroxide of vitamin D or the like (e.g., hydroxy vitamin D3) can be produced with high efficiency.
An object is to establish a process for production of a novel polysaccharide from a cassis polysaccharide (CAPS), wherein the novel polysaccharide can show a higher immunomodulating effect per unit amount, has a low viscosity, and can be handled readily during the process for producing a final product. Another object is to provide a health beverage/food having high safety and an excellent immunomodulating effect at a low cost by utilizing a juice, a processed juice or a purified product. Thus, disclosed is a composition mainly comprising a novel polysaccharide having an average molecular weight of about 10,000 to 40,000, wherein the polysaccharide is produced by a restrictive and partial enzymatic digestion of a CAPS. Also disclosed is an immunomodulating beverage/food using the composition.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
An indene derivative can be used as an intermediated for the synthesis of a vitamin D2 derivative paricalcitol which is useful as a pharmaceutical. The indene derivative can be produced with high efficiency by subjecting a vitamin D2 derivative such as 25-hydroxyvitamin D2 to a two-stage oxidation reaction in a proper solvent such as methanol and ethanol using an oxidizing agent such as potassium permanganate and sodium periodate.
C07C 45/29 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by oxidation of hydroxy groups
C07C 45/28 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by oxidation of —CHx-moieties
C07C 45/58 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds from heterocyclic compounds with oxygen as the only hetero atom in three-membered rings
C07C 49/743 - Unsaturated compounds containing a keto group being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
C07C 49/753 - Unsaturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
C07C 67/313 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
C07C 69/145 - Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
C07C 401/00 - Irradiation products of cholesterol or its derivativesVitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
C07D 301/14 - Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
C07D 303/14 - Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
C07F 7/18 - Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
FIBROBLAST ACTIVATOR, METHOD FOR ACTIVATION OF FIBROBLAST, COLLAGEN SYNTHESIS PROMOTER, METHOD FOR PROMOTION OF COLLAGEN SYNTHESIS, SKIN AGING-PREVENTING AGENT, AND METHOD FOR PREVENTION OF AGING OF THE SKIN
Disclosed are: a fibroblast activator comprising a grape sap as an active ingredient; a method for activation of a fibroblast using a grape sap; use of a grape sap as a fibroblast activator; a collagen synthesis promoter comprising a grape sap as an active ingredient; a method for promotion of the collagen synthesis using a grape sap; use of a grape sap as a collagen synthesis promoter; a skin aging-preventing agent comprising a grape sap as an active ingredient; a method for prevention of the aging of the skin using a grape sap; and use of a grape sap as a skin aging-preventing agent. A highly safe, effective means for prevention of the aging of the skin can be provided.
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
⏧PROBLEMS] To provide a process for through simple and easy processing, efficiently producing a fruit, or juice or alcoholic beverage, containing -aminobutyric acid in high concentration. ⏧MEANS FOR SOLVING PROBLEMS] A fruit containing -aminobutyric acid in high concentration is produced by a process comprising either conducting an operation consisting of an anaerobic treatment of raw fruit followed by an aerobic treatment thereof once, or repeating the operation twice or more followed by an anaerobic treatment to thereby obtain a fruit with a -aminobutyric acid content enhanced over that of the raw fruit. A juice or alcoholic beverage is produced from the fruit containing -aminobutyric acid in high concentration.
