The present invention provides a sustained release composition having hyperbranched polymers that are polyesters that are biobased and biodegradable, and that have at least one active ingredient, which composition delivers the active ingredient over time. These active ingredients can be a wide variety of compounds so long as they can covalently bind to the polymer or be encapsulated in the polymer in a manner that is released at the point of delivery, usually by acid hydrolysis or enzymatic bond scission.
A01N 35/02 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio-analogues thereofDerivatives thereof, e.g. acetals
A01N 37/10 - Aromatic or araliphatic carboxylic acids, or thio-analogues thereofDerivatives thereof
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
C08G 63/12 - Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
C08G 63/91 - Polymers modified by chemical after-treatment
C08L 101/00 - Compositions of unspecified macromolecular compounds
C08L 101/16 - Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable
2.
Selection and use of lactic acid bacteria preventing bone loss in mammals
The present invention comprises a method for selecting lactic acid bacterial strains effective for preventing bone loss in humans and strains that have been selected according to the presented method. The selection method is based on the strain's capability of reestablishing an altered microbial community to normal and/or harboring at least one of four specific SNPs.
FUNDACIÓN PÚBLICA ANDALUZA PROGRESO Y SALUD (Spain)
MICHIGAN STATE UNIVERSITY (USA)
INSTITUTO DE SALUD CARLOS III (Spain)
Inventor
Cibelli, Jose B.
Gonzalez-Muñoz, María Elena
Abstract
Provided herein are methods and compositions for inducing a somatic cell to acquire a less differentiated phenotype and for generating induced pluripotent stem cells (i PS cells) by inducing expression of ASF1A in the cell and/or by contacting the cell with GDF9. Also provided herein are compositions and methods for treating and/or diagnosing cancer and for identifying agents useful in the treatment and/or diagnosis of cancer.
The present invention comprises a method for selecting lactic acid bacterial strains effective for preventing bone loss in humans and strains that have been selected according to the presented method. The selection method is based on the strains capability of reestablishing an altered microbial community to normal and/or harboring at least one of four specific SNPs (C in base pair 271 391, G in base pair 453 538, G in base pair 529 228, and C in base pair 599 338 relative to the genome of L reuteri JCM 1 1 12).
The present invention comprises a method for selecting lactic acid bacterial strains effective for preventing bone loss in humans and strains that have been selected according to the presented method. The selection method is based on the strains capability of reestablishing an altered microbial community to normal and/or harboring at least one of four specific SNPs (C in base pair 271 391, G in base pair 453 538, G in base pair 529 228, and C in base pair 599 338 relative to the genome of L reuteri JCM 1 1 12).
A process for the preparation of new polyols and polyesters from a natural oil or other unsaturated fatty acid esters is described. The process involves ozone cleavage of double bonds in the fatty acid chains of the oils along with coupling of a hydroxylated compound such as a mono-alcohol, a diol, or a polyol to the cleaved ends of the molecules resulting from the cleavage with a base. The resulting polyols and polyesters are as intermediates for polymers.
C07C 67/30 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
C07C 59/42 - Unsaturated compounds containing hydroxy or O-metal groups
A moisture-curable, silane-modified oil is disclosed. The silane-modified oil includes an unsaturated oil having at least one unsaturated aliphatic hydrocarbon chain per molecule of the unsaturated oil, and at least one hydrolysable silyl group grafted to the unsaturated aliphatic hydrocarbon chain. The silane-modified oil has a degree of unsaturation that is substantially similar that of the unsaturated oil. A process for forming the moisture-curable, silane-modified oil according to the disclosure includes reacting the unsaturated oil with an unsaturated hydrolysable silane in the presence of a free radical initiator. Also disclosed is a cured silane-modified oil which includes the reaction product of the silane-modified oil and water. Compositions according to the disclosure have relatively low viscosities (facilitating their application to a substrate) and have relatively high levels of silane grafting (resulting in non-leaching cured compositions with a high gel content).
An isolated cell from the cell line identified as TnT4. This cell may be infected with a baculovirus expression vector which may carry a heterologous nucleotide that encodes a polypeptide, such as a membrane protein, e.g., human neurotensin receptor 1. Also included is a method for using this cell line to produce a polypeptide, such as a membrane protein; and a method for identifying a cell-of-interest which expresses a protein-of-interest.
A avian cell line that supports replication of animal or human viruses, which cell line is adapted to animal-product free growth. The cell line is useful for propagating a virus suitable as a live or a killed vaccine and for virus isolation and diagnostic assays.
The present invention relates to a microwave plasma deposition process and apparatus for producing diamond, preferably as single crystal diamond (SCD). The process and apparatus enables the production of multiple layers of the diamond by the use of an extending device to increase the length and the volume of a recess in a holder containing a SCD substrate as layers of diamond are deposited. The diamond is used for abrasives, cutting tools, gems, electronic substrates, heat sinks, electrochemical electrodes, windows for high power radiation and electron beams, and detectors.
C30B 9/00 - Single-crystal growth from melt solutions using molten solvents
C23C 16/00 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
A bacterial conversion process for producing a homopolymer, poly (3-hydroxypentanoic acid) from levulinic acid, is described. The process uses Rhizobium sp. to accomplish the conversion. The polymer is biodegradable and has a favorable glass transition temperature and melting point. It is useful in any setting where a biopolymer is used.
The present inventions relate to compositions and methods for providing drought resistant grass plants comprising Festuca inairei plant geπnplasm. Specifically, the inventions relate to providing compositions and methods for introgressing Fcsiuca niaii ci geπnplasm and/or specific Festuca inairei genes into grass plants, such as Loliitm pei enne plants. Further, the invention relates to methods of grass plant breeding comprising genetic markers for identifying the preferred Festuca inairei germplasm introgressed into grass plants, and providing commercially desirable drought resistant cultivars of grass plants.
The present invention relates to eco-friendly compositions and methods for providing plant growth enhancing formulations comprising mixtures of microbial isolates. In particular, numerous bacterial and fungal strains were isolated from a variety of soil types, from rhizospheres and from root nodules of leguminous plants, in designed combinations, for providing plant growth and plant productivity enhancing formulations. These specifically designed polymicrobial formulations would further provide protection against plant pathogens lowering the need for nitrogen containing fertilizers, solubilize minerals, protect plants against pathogens, and make available to the plant valuable nutrients, such as phosphate, thus reducing and eliminating the need for using chemical fertilizers and chemical pesticides.
C05F 11/08 - Organic fertilisers containing added bacterial cultures, mycelia or the like
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
17.
CHANNEL CAPACITY ESTIMATION AND PREDICTION METHOD AND APPARATUS FOR RATE ADAPTIVE WIRELESS VIDEO
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE (Republic of Korea)
MICHIGAN STATE UNIVERSITY (USA)
Inventor
Cho, Yong-Ju
Yoo, Jeong-Ju
Hong, Jin-Woo
Hayder, Radha
Shirish, Krande
Kiran, Misra
Abstract
There is provided a channel capacity estimation method for adaptive video transmission, the method including: estimating a Bit Error Rate (BER) for a received video packet; and estimating channel capacity by using the estimated BER.
The present inventions generally relate to compositions and methods for providing agricultural chemicals comprising active ingredients (A.I.s) combined with a top dressing for application to cultivated areas of turfgrass. Further, the inventions relate to compositions and methods for delivering active ingredients simultaneously with a top dressing composition to golf course turf.
The invention relates to methods for altering the fate or differentiation status of somatic cells by RNA transfer. These methods can be used to transdifferentiate or dedifferentiate somatic cells of one phenotype or lineage into pluripotent cells or into somatic cells of a different lineage or phenotype.
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
This invention contemplates an accurate and efficient estimation of gene copy number using oligonucleotide microarrays. The method integrates gene copy number data obtained from perfect match and mismatch probe sequence structure intensities and probe binding affinities. In one embodiment, an accurate determination of single nucleotide polymorphisms (SNPs) sequences is obtained. In another embodiment, an accurate detection and determination of DNA copy number alteration is obtained. In another embodiment, an accurate estimation for RNA gene expression is obtained.
The present invention relates to recombinant feline herpes virus type 1 (FHV-1) nucleic acids and proteins. In particular the present invention provides compositions comprising the full length FHV-1 genome or portions thereof, and infectious FHV-1 virions produced therefrom. The FHV-1 compositions are suitable for use in inducing an immune response in inoculated subjects and for use in identifying agents that attenuate FHV-1 infection.
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
The invention relates to compositions comprising substituted imidazoline compounds including prodrugs, and salts thereof. In some embodiments, the invention relates to the use of these compositions as therapeutic agents, preferably for the treatment of arthritis or cancer. In further embodiments, The invention relates to the pharmaceutical compositions with effective amounts of substituted imidazoline compounds disclosed herein that function as agonist or antagonists of the genetic expression or interactions with transcription factor NF-κB.
A process for producing sugars from lignocellulosic materials such as com stover by the addition of corn stillage as a carbon source is disclosed. The sugars are formed by treating the combination of the corn stillage and the lignocellulosic materials with hydrolytic enzymes. The sugars can be fermented to ethanol, and the process improves ethanol production economies with an increased sugar yield from the lignocellulosic materials.
Low resistivity graphite coated particles having exfoliated and pulverized graphite platelets coated on an outer surface of high resistivity particles are provided. Various methods are also provided for surface coating of the graphite platelets onto the particles to increase particle conductivity. The graphite coated particles can be used to produce reinforced composite materials. Reinforced composite materials incorporating the graphite coated particles can be electrostatically painted without using a conductive primer on the composite.
B32B 15/04 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance
Composite materials with a polymer matrix, low resistivity graphite coated fillers having exfoliated and pulverized graphite platelets coated on an outer surface of high resistivity fillers, are provided. The fillers can be fibers or particles. The composite materials incorporating the graphite coated fillers as reinforcements can be electrostatically painted without using a conductive primer on the polymer matrix.
B05D 5/12 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain a coating with specific electrical properties
Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide- substituted organic compounds). Alkynyl and azide groups react via the 'click' chemistry mechanism to form functional groups covalently bonded to the polymer via a triazole link. The polymers are biodegradable and can be used to deliver drugs or other therapeutic substances (e.g., large biomolecules such as single strand RNA) at targeted locations in a patient's body and/or at controlled release rates.
Method and apparatus are introduced for determining proportional cardiac output (CO), absolute left atrial pressure (LAP), and/or other important hemodynamic variables from a contour of a circulatory pressure waveform or related signal. Certain embodiments of the invention provided herein include the mathematical analysis of a pulmonary artery pressure (PAP) waveform or a right ventricular pressure (RVP) waveform in order to determine beat-to-beat or time-averaged proportional CO, proportional pulmonary vascular resistance (PVR), and/or LAP. The invention permits continuous and automatic monitoring of critical hemodynamic variables with a level of invasiveness suitable for routine clinical application. The invention may be utilized, for example, to continuously monitor critically ill patients with pulmonary artery catheters installed and chronically monitor heart failure patients instrumented with implanted devices for measuring RVP.
Constructs and methods are provided for altering extracellular lipids in plants. In general, the methods include increasing expression of an acyltransferase and a fatty acid oxidase in the plant.
Compositions including composites of polyvinyl chloride (PVC) and nanoparticles are disclosed. A wood-polymer composite using the PVC-nanoparticle composite as a matrix also is disclosed. The nanoparticle filler is dispersed throughout the PVC matrix by blending the nanoparticles with a mixture of PVC particles that have been pre-heated to a temperature at or above a fusion point of the PVC, thereby fusing the PVC particles prior to the addition of the nanoparticles to the matrix. Also disclosed are methods of forming the composite compositions. The composite compositions can be used to replace wood boards.
B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sinteringApparatus specially adapted therefor
31.
METHOD FOR GENERATING ALKALI METAL PHOSPHIDES THROUGH REDUCTION OF TRI-SUBSTITUTED PHOSPHINES WITH ALKALI METAL POROUS OXIDE COMPOSITIONS
Alkali metal phosphides are useful intermediates for the synthesis of a variety of phosphine derivatives. Many of these phosphine derivatives are important industrial compounds with applications as synthetic intermediates or as ligands in a variety of homogeneous and heterogeneous synthetic processes. Alkali metal diarylphosphides in particular have been used in the synthesis of many phosphine ligands of importance. The invention relates to methods for generating and using alkali metal phosphides by reduction of the phosphorus sigma bonds of tri-substituted phosphorus derivatives with Group I metal/porous oxide compositions. Formula (I).
The invention relates to a method of treating obesity or IBS in an individual by administering a physiologically acceptable composition comprising a helminthic parasite, or an active variant thereof, that is of a type and present in an amount sufficient to treat the individual for obesity or IBS. The invention is not limited to obesity and IBS and is further drawn to conditions of health in which the microbiota profile for a population of microbes found within an individual contributes to a pathological condition.
A transgenic maize plant and methods of using the transgenic maize plant having at least a portion of a coding region of one or more lignin biosynthesis pathway enzymes. In one embodiment, the transgenic plant expresses short interfering RNA (siRNA) for the one or more lignin biosynthesis pathway enzymes that forms a double-strand to activate RNA interference (RNAi). The RNAi decreases expression of the one or more lignin biosynthesis pathway enzymes in the transgenic plant. In a second embodiment, the transgenic plant has a cDNA for the one or more lignin biosynthesis pathway enzymes to increase expression of the one or more lignin biosynthesis pathway enzymes in the transgenic plant.
A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
The present inventions relate to compositions and methods for providing drought resistant grass plants comprising Festuca tnairei plant germplasm. Specifically, the inventions relate to providing compositions and methods for introgressing Festuca mairei germplasm and/or specific Festuca mairei genes into grass plants, such as Lolium perenne plants. Further, the invention relates to methods of grass plant breeding comprising genetic markers for identifying the preferred Festuca mairei germplasm introgressed into grass plants, and providing commercially desirable drought resistant cultivars of grass plants.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
C12N 15/29 - Genes encoding plant proteins, e.g. thaumatin
The invention relates to the use of phospholipase C zeta in inducing or promoting the activation of oocytes, preferably human oocytes, nuclear transfer embryos, parthenogenic embryos, cross species embryos and during in vitro fertilization. The invention further relates to methods of detecting levels of expression of phospholipase c zeta in sperm as a means of detecting male infertility. The invention also relates to the use of phospholipase C zeta to treat male infertility. Still further the invention relates to the recombinant cells that are engineered to express phospholipase C zeta, preferably under inducible conditions. Also, the invention relates to antibodies specific to phospholipase C zeta, preferably human phospholipase C zeta.
A homopolymer of 1, 4-benzodioxepin-3-cyclohexyl- 2,5-dione with a Tg of 120°C. Copolymers are also described. The polymers are useful for surgical and other applications where biodegradability is important.
C08G 79/02 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon a linkage containing phosphorus
37.
METHOD FOR PRODUCING COMPOSITIONS FOR NANOPARTICLES ON SOLID SURFACES
A method for producing nanoparticles on a substrate us ing a metal precursor in an ionic liquid and microwave heating is described. The composite compositions are useful as catalysts for chemical reactions, fuel cell, supercapacitor and battery components, and the like.
The present invention relates to compositions and methods for providing a recombinant thermostable Thermotoga neapolitana alkaline phosphatase enzyme. More particularly, the invention relates to engineering Escherichia coli with T. neapolitana alkaline phosphatase gene expression vectors for providing an inducible system for thermostable enzyme production, wherein the expressed enzyme is readily soluble with a high degree of activity. These methods provide for commercial quantities of a thermostable alkaline phosphatase enzyme.
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
39.
HUMAN TRANSCRIPTOME CORRESPONDING TO HUMAN OOCYTES AND USE OF SAID GENES OR THE CORRESPONDING POLYPEPTIDES TO TRANS-DIFFERENTIATE SOMATIC CELLS
The identification of 101 genes upregulated or differentially expressed by mature human oocytes is provided herein. These genes and the corresponding gene products will facilitate a greater understanding of oogenesis, folliculogenesis, fertilization, and embryonic development. In addition these genes and the corresponding gene products can be used to effect dedifferentiation and/or transdifferentiation of desired somatic cells. The resultant dedifferentiated cells and somatic cells derived therefrom can be used in cell therapies such as in the treatment of cancer, autoimmunity, and other diseases wherein specific types of cells such as hematopoietic cells may be depleted because of the underlying disease or the treatment of the disease. Also, a core group of 66 transcripts was identified by intersecting significantly up-regulated genes of the human oocyte with those from the mouse oocyte and from human and mouse embryonic stem cells. Within the up-regulated probe sets, the top overrepresented categories were related to RNA and protein metabolism, followed by DNA metabolism and chromatin modification. This invention therefore provides a comprehensive expression baseline of genes expressed in in vivo matured human oocytes. Further understanding of the biological role of these genes will also expand knowledge on meiotic cell cycle, fertilization, chromatin remodeling, lineage commitment, pluripotency, tissue regeneration, and morphogenesis.
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12N 5/02 - Propagation of single cells or cells in suspensionMaintenance thereofCulture media therefor
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
40.
SEPARATION OF PROTEINS FROM GRASSES INTEGRATED WITH AMMONIA FIBER EXPLOSION (AFEX) PRETREATMENT AND CELLULOSE HYDROLYSIS
A process for extracting an aqueous ammonium hydroxide solution from a plant biomass after an Ammonia Fiber Explosion (AFEX) process step, is described. The proteins can be separated before or after a hydrolysis of sugar precursors (carbohydrates) from the biomass to produce sugars for fermentation to produce ethanol. The proteins are useful as animal feeds because of their amino acid food values.
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
41.
MOLECULAR DESIGN OF THERMOSTABLE ALCOHOL DEHYDROGENASE FOR SYNTHESIS FOR CHIRAL AROMATIC ALCOHOLS
The present invention relates to compositions and methods utilizing thermostable and novel alcohol dehydrogenase enzymes for biosynthesizing chiral specific molecules for use as precursor molecules in synthesizing pharmaceutical compounds. Particularly, in preferred embodiments, the invention relates to directed engineering of an enzymatic catalytic site of an alcohol dehydrogenase enzyme gene for enhancing enantioselectivity for (S)-enantiomer substrate catalytic activity for providing aryl (S)-enantiomer products in stereomeric excess.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
42.
IDENTIFICATION OF GENES OR POLYPEPTIDES THE EXPRESSION OF WHICH CORRELATES TO FERTILITY, OVARIAN FUNCTION AND/OR FETAL/NEWBORN VIABILITY
A genetic means of determining whether a female subject produces 'pregnancy competent' oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, or pattern referred to herein as the 'pregnancy signature', also can be used to identify subjects with underlying conditions that impair or prevent the development of a viable pregnancy, e.g., pre-menopausal condition, other hormonal dysfunction, ovarian dysfunction, ovarian cyst* cancer or other cell proliferation disorder, autoimmune disease and the like. Microarrays containing 'pregnancy signature' genes or corresponding polypeptides provide another preferred aspect of the invention. Still further, the subject invention can be used to derive animal models, e.g., non- human primate animal models, for the evaluation of the efficacy of putative female fertility treatments.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
Low resistivity graphite coated fibers having exfoliated and pulverized graphite platelets coated on an outer surface of electrically insulating fibers are provided. Various methods are also provided for surface coating of the graphite platelets onto the insulating fibers which are provided to increase the glass fiber surface conductivity. The graphite coated glass fibers can be used to produce reinforced composite materials. Reinforced composite materials incorporating the graphite coated fibers can be electrostatically painted without using a conductive primer.
Derivatives of geldanamycin (GA), a benzoquinone ansamycin antibiotic, are in clinical trials as anticancer drugs. While, at nanomolar concentrations, these drugs are known to target HSP90 chaperone activity, second anticancer activity that inhibits HGF/SF-mediated tumor cell invasion at nanomolar concentrations has been found. Disclosed is the identification of the outer membrane mitochondrial voltage-dependent anion channel (VDAC) protein, a component of the permeability transition pore (PTP), as a novel GA binding protein and a demonstration that GA inhibits membrane potential at picomolar levels. Uubiquinone 0 and decyl-ubiquinone, known benzoquinone inhibitors of mitochondrial PTP function like GA, inhibit HGF/SF induced urokinase (uPA) plasmin protease activation and HGF/SF activated membrane currents in whole-cell voltage clamp assays, with GA blocking at picomolar levels. The results disclosed regarding mechanism of action are a major step in harnessing such drugs for use for treating highly invasive cancers like glioblastoma.
A process for the treatment of biomass to render structural carbohydrates more accessible and/or digestible using concentrated ammonium hydroxide with or without anhydrous ammonia addition, is described. The process preferably uses steam to strip ammonia from the biomass for recycling. The process yields of monosaccharides from the structural carbohydrates are good, particularly as measured by the enzymatic hydrolysis of the structural carbohydrates. The monosaccharides are used as animal feeds and energy sources for ethanol production.
Zeolites with uniform intracrystal textural pores between 1 and 10 nm are described. Intracrystal pores, an alumina source and a silica source are reacted in the presence of a silane modified polymer as a porogen and the reaction product is calcined to form the zeolite. The zeolites are useful in catalytic reactions and adsorption processes.
C01B 33/36 - Silicates having base-exchange properties but not having molecular sieve properties
C01B 39/00 - Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolitesTheir preparationAfter-treatment, e.g. ion-exchange or dealumination
The invention relates to compounds and compositions to treat some neurodegenerative diseases. In some embodiments, the invention relates to an antioxidant comprising a selenium atom and nitroxide group. In further embodiments, the antioxidant comprises peroxidase and superoxide dismutase activity. In some embodiments, the antioxidants are effective in treating neurodegenerative diseases including, but not limited to, Alzheimer's disease, Parkinson's disease, or multiple sclerosis. In additional embodiments, the invention relates to using compounds disclosed herein as free radical electromagnetic imaging agents.
A61K 31/54 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
A61K 31/421 - 1,3-Oxazoles, e.g. pemoline, trimethadione
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
C07D 421/02 - Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings
C07D 403/02 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings
48.
REACTIVELY BLENDED POLYESTER AND FILLER COMPOSITIONS AND PROCESS
High-performance inorganic filled thermoplastic polyester composites are provided, and the process for preparing thereof. Biodegradable inorganic filled thermoplastic polyester composites are provided by reactive melt-blending of biodegradable thermoplastic polyesters with inorganic fillers using a reactive extrusion processing.
A bioadhesive composition from distillers' dried grains with solubles (DDGS) is produced by reaction with an aqueous solution of a base, particularly, sodium hydroxide. Optionally, urea is included with the base. The bioadhesive composition is filtered as a solution from the residue of the reaction with the base. The bioadhesive composition s particularly useful as a boxboard glue.
A01N 65/00 - Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
50.
GELDANAMYCIN DERIVATIVES AND METHOD OF USE THEREOF
The present invention relates to novel geldanamycin derivatives which have antitumor and antiparasitic properties. The geldanamycin derivatives disclosed herein have antitumor properties in humans due to their interaction with human heat shock protein 90 (hsp90). The human parasites Plasmodium falciparum, Trypanosoma Cruzi, and Leishmania donovani are lethally susceptible to exposure to geldanamycin via complexation of geldanamycin with their homologs (Pfhsp90, hsp83, and hsp90, respectively) of the human hsp90. The geldanamycin derivatives disclosed herein also interact with these parasitic hsp90 homologs so as to have antiparasitic properties.
C07D 225/06 - Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
C07D 211/60 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
A chemical composite useful for preparing a bioelectronic device includes a biologically active compound, such as an enzyme, that is bound directly or indirectly to a polyelectrolyte, which can be reversibly coupled to a chemically treated electrically conductive substrate by electrostatic forces to provide biomimetic sensors, catalyst systems, and other devices having an electrode that can be regenerated and reused. Required or desired cofactors, mediators or the like may be incorporated into the devices, typically by bonding them to the treated substrate and/or the polyelectrolyte.
The present invention discloses that essential and highly conserved GTPases (i.e., for example, YIqF, YqeH, YsxC, or YphC proteins) from Bacillus subtilis participate in ribosome biogenesis. Before this invention, the biological function of the GTPase proteins were unknown. These GTPase proteins are disclosed to affect translation and believed to promote ribosome biogenesis. For example, cells depleted of YIqF protein accumulate a precursor of the 5OS subunit that migrates at 45S, suggesting a role in assembly of the large ribosomal subunit. Analysis of the protein content of the 45S particle showed that ribosomal protein Ll6 is missing from the large subunit. Inhibitors of GTPase-ribosomal interactions (i.e., for example, ribosomal protein or ribosomal nucleic acids) comprise a novel class of antimicrobial compounds.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Disclosed are genetic constructs, transgenic plant cells and transgenic plants, as well as associated methods, for increasing oil production in a plant using F-box gene sequences.
Disclosed is an elongation reaction system that includes a membrane compatible with binding an elongation complex and an elongation complex compatible with binding the membrane. The elongation complex includes the biological template (e.g., DNA or RNA), a polymerizing agent (e.g., RNA polymerase, DNA polymerase, or a ribosome), and a primer transcript or polypeptide. Further, disclosed is an apparatus and method for solid-phase kinetic analysis of templated elongation reactions.
A minimal defined medium for growth of A. succinogenes in an anaerobic environment is described. The medium expands the experimental opportunities for studying the metabolism of A. succinogenes, including 13C-labeling experiments . The medium comprises essential amino acids . Other ingredients are also essential such as glucose or another carbohydrate as the primary carbon source, minerals, and vitamins . The medium allows for 13C-labelling experiments that can reveal the metabolic pathways used by A. succinogenes and the extent to which they are used, including those pathways involved in succinate production
A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
A method for determining whether endocrine therapy is contra-indicated in an individual, including detecting the presence of MP1 protein. A method for identifying an inhibitor of MP1 activity in a mammary cell.
lH-Pyrrolo-l,4-thiazines and a process for the preparation thereof are described. These compounds are useful as enzyme inhibitors in cells, particularly for medical uses.
C07D 279/16 - 1,4-ThiazinesHydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
59.
TRANSGENIC MOUSE MODEL AND METHODS FOR TREATMENT OF NEURO MUSCULAR DISEASE BY INTERFERING WITH ANDROGEN-ANDROGEN RECEPTOR INTERACTION IN SKELETAL MUSCLES
The present invention describes a transgenic mouse susceptible to neuromuscular disease. The present invention also includes methods for treatment of neuromuscular diseases by interfering with activity between androgen and androgen receptors exclusively in the muscle fibers.
Specific polymer blends of polylactic acid (PLA) and polyhydroxybutyrate (PHB) and poly-(butylenes adipate-co-terephthalate (PBAT) as a fatty acid quaternary ammonium modified clay. The blends are particularly useful for barrier packaging.
C08K 9/04 - Ingredients treated with organic substances
C08L 67/00 - Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chainCompositions of derivatives of such polymers
61.
GENES FROM ACTINOBACILLUS SUCCINOGENES 13OZ (ATCC 55618) FOR PRODUCTION OF CHEMICALS FROM THE A. SUCCINOGENES C4-PATHWAY
Actinobacillus succinogenes genes and methods of using the genes in genetically engineered A. succinogenes so as to improve production of chemicals such as succinate, fumarate, malate, 5-aminolevulinate, 2-oxoglutarate, glutamate, and aspartate. The genetically engineered A. succinogenes strains are capable of overexpressing C4 enzymes. The genetically engineered A. succinogenes can have one or more gene knockouts or modifications that inhibit C3 enzymes. The fluxes supplying substrate to the C4 pathway can also be improved in some of the genetically engineered A. succinogenes.
A method and biosensor device for detecting single strand target DNA of a microorganism by cyclic voltammetry is described. A porous silicon chip is linked to bound single strand DNA complementary to the target DNA. The device is particularly useful for detecting microorganisms which may be pathogenic.
A process for producing cyano substituted arene boranes is described. The compounds are useful intermediates to pharmaceutical compounds using the cyano group as a reactant.
C07D 207/06 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
A process for producing bulk thermoelectric compositions containing nanoscale inclusions is described. The thermoelectric compositions have a higher figure of merit (ZT) than without the inclusions. The compositions are useful for power generation and in heat pumps for instance.
Conductimetric assay devices that have both low end and high end sensitivity are described. The geometric shape and/or arrangement of the capture zones make it possible for the assay devices to have both low end and high end sensitivity. Also described is a conductimetric assay device having a pre-capture zone to capture unbound analyte. The assay device overcomes the problem of flooding by the analyte.
Inhomogeneous tissue structures cause spatial-varying water molecule diffusion that is characterized by the spatial derivative of diffusivity, i.e., diffusion .gradient. In a magnetic resonance imaging (MRI) system, the effects of diffusion and diffusion gradient are simultaneously encoded in an echo signal using diffusion- encoding magnetic field gradient pulses. A method for imaging the diffusion gradient of water molecules in tissues and for delineating the interface between two tissues having different diffusion properties is disclosed. The method also describes imaging diffusion anisotropy and diffusion gradient simultaneously without any additional scans in comparison with diffusion tensor MRI .
Extruded composite compositions of PVC and wood particles containing chitosan or chitin as a coupling agent are described. The composite compositions have improved physical and mechanical properties .
B29C 47/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor (extrusion blow-moulding B29C 49/04)
68.
HYPERBRANCHED POLYMER MODIFIED BIOPOLYMERS, THEIR BIOBASED MATERIALS AND PROCESS FOR THE PREPARATION THEREOF
Compositions of biodegradable polymers and hyperbranched dendritic polymer (HBP) are described. The compositions can also include anhydride modified HBP. The resulting compositions have superior elongation at break and can be as cast or blown films for packaging, for example.
B29B 17/00 - Recovery of plastics or other constituents of waste material containing plastics
B29C 47/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor (extrusion blow-moulding B29C 49/04)
69.
Tomographic imaging system using a conformable mirror
A tomographic imaging system comprising a source array emitting rays, a deformable mirror reflecting the rays emitted by the source array, and a detector array receiving the electromagnetic rays emitted by the source array and reflected by the deformable mirror. An object can be positioned between the deformable mirror and the detector array and the deformable mirror can be deformed to a plurality of configurations to form a tomographic image of the object. The system can also be used in radiation therapy.
Methods are provided for identifying compounds that decrease the expression or activity of an overexpressed Sprouty protein in certain cancers. Such compounds can be useful for treating cancers in which a Sprouty protein is overexpressed. Also provided are therapeutic formulations and pharmaceutical formulations for treating cancers characterized by overexpression of a Sprouty protein.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
71.
YERSINIA POLYPEPTIDE VACCINES, ANTIBODIES AND IMMUNOMODULATORY PROTEINS
Disclosed are compositions, including LcrV antigenic polypeptides, vaccines and antibodies, as well as associated methods for treating and/or preventing Yersinia infection in a host. The invention further provides immunomodulatory LcrV proteins and polypeptides comprising TLR2 and IFN-R-IFN- -binding sequences that stimulate host anti-inflammatory responses and repress pro-inflammatory responses.
C07K 14/24 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
C07K 4/04 - Peptides having up to 20 amino acids in an undefined or only partially defined sequenceDerivatives thereof from bacteria
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
72.
NOVEL TRIGLYCERIDES AND METHOD OF PREPARATION THEREOF
A process for the preparation of new polyols from a natural oil is described. The process involves ozone cleavage of double bonds in the fatty acid chains of the oils along with coupling of a di or polyol to the cleaved ends of the molecules resulting from the cleavage with a base. The resulting polyols are as intermediates for polymers.
Fuel oxygenates comprised of fatty acid or fatty acid ester derivatives which have been reacted with ozone; a base; and a lower alkanol (1 to 8 carbon atoms) are described. The oxygenates comprise ester groups at a point of cleavage by the ozone which provide oxygen in the oxygenate.
A process for the preparation of a fuel oil (diesel fuel or heating oil) composition which is a mixture of an alkanol tranesterified fatty acid ester triglyceride and an acetal of glycerol is described. The process preferably provides a prestep of the formation of at least some of the alkanol transesterif ied triglyceride containing the glycerol for use in the formation of the acetal of glycerol . The composition can also be formed from a reaction of 1,1- dimethoxy- or 1, l-diethoxye thane and glycerol to form the acetal in the alkanol transesterif ied triglyceride.
Yersinia pestis and plague. Moreover, the present invention concerns methods and compositions for suppressing a subject's immune system using non-native LcrV polypeptides.
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
76.
Devices and methods for interlocking surgical screws and nails
The present invention demonstrates an improved interlocking nail and screw combination to repair fracture bones. The preferred combination uses an hourglass shaped intramedullary nail wherein the larger ends of the nail have holes capable of receiving screws. The holes may, or may not be conical. Further, the holes may or may not be threaded. The surgical screws have a variety of thread patterns, or lack threads. A non-threaded end is believed to improve healing because of a larger core diameter as compared to a comparably sized threaded screw end.
A method for detecting a latent environmental effect (such as a corrosive environment under insulation) or a latent structural change (such as a crack in a concealed structural member) at a known remote concealed location. The method of the instant invention includes three steps. The first step is to use a harmonic electromagnetic transponder at the known remote concealed location of the latent environmental effect or the latent structural change, the harmonic electromagnetic transponder having a reactive portion which reacts to the latent environmental effect or latent structural change to modify the harmonic emission of the transponder. The second step is to remotely interrogate the transponder by directing electromagnetic radiation at the transponder. The third step is to use the harmonic emission of the transponder to remotely determine the latent environmental effect or the latent structural change.
A transformed plant is provided which comprises one or more environmental stress tolerance genes; a DNA regulatory sequence which regulates expression of the one or more environmental stress tolerance genes; a sequence encoding a binding protein capable of binding to the DNA regulatory sequence and inducing expression of the one or more environmental stress tolerance genes; and a recombinant promoter which regulates expression of the gene encoding the binding protein. A method for altering an environmental stress tolerance of a plant is also provided which comprises the steps of transforming a plant with a promoter which regulates expression of at least one copy of a gene encoding a binding protein capable of binding to a DNA regulatory sequence which regulates one or more environmental stress tolerance genes in the plant; expressing the binding protein encoded by the gene; and stimulating expression of at least one environmental stress tolerance gene through binding of the binding protein to the DNA regulatory sequence.
