Disclosed are methods and apparatuses for microvascular system imaging. In some embodiments, an apparatus for microvascular system imaging is a probe including at least one high-resolution image sensor module, at least one lens set, one or more optical filters, an illumination source, and a housing. In some embodiments, the lens set may be a miniature lens set. In some embodiments, the housing may be a tube structure. In some embodiments, the tube may be covered with a protective and/or sterile cover. The cover may be optically non-distorting. The imaging probe may additionally include a removable cap.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
2.
A METHOD AND APPARATUS FOR MICROVASCULAR VESSEL IMAGING
Disclosed are methods and apparatuses for microvascular system imaging. In some embodiments, an apparatus for microvascular system imaging is a probe including at least one high-resolution image sensor module, at least one lens set, one or more optical filters, an illumination source, and a housing. In some embodiments, the lens set may be a miniature lens set. In some embodiments, the housing may be a tube structure. In some embodiments, the tube may be covered with a protective and/or sterile cover. The cover may be optically non-distorting. The imaging probe may additionally include a removable cap.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
3.
COMPOSITIONS, SYSTEMS, AND METHODS FOR ASSESSING AND IMPROVING VASCULAR HEALTH AND TREATMENTS INVOLVING THE SAME
Compositions, systems, and methods for assessing or improving vascular health, treatments or treatment methods involving the same, systems and methods for diagnosing vascular health or impairment, and compositions and methods for use in treating endothelial glycocalyx to improving vascular health or treat a (vascular health-associated) disease or other condition, in human and non-human mammals are disclosed. Computer systems, hardware storage devices, and methods used to determine glycocalyx impairment using a dynamically extrapolated characterization of a plurality of microvascular vessels, diagnose a subject as suffering from glycocalyx dysfunction or impairment, and assess or determine the health, functionality, or impairment of the glycocalyx as a function of blood flow. Compositions comprising glucosamine, hyaluronan, fucoidan, and antioxidants improve vascular health by enhance synthesis of new glycocalyx, protecting existing glycocalyx against damage, and enhancing repair of damaged glycocalyx.
Compositions and methods for treating endothelial glycocalyx include glucosamine, hyaluronan and/or fucoidan, and one or more antioxidants, such as superoxide dismutase, catalase, and/or polyphenol. The compositions improve vascular health by exhibiting beneficial synergistic effects on endothelial glycocalyx over the benefits of taking any single component alone or the sum of reported effects of the individual components. Specifically, components of the composition (1) enhance synthesis of new glycocalyx by (a) providing and (b) increasing production of glycocalyx precursors, (2) protecting existing glycocalyx against damage, such as by oxidation degradation, by (a) providing and (b) increasing production of antioxidants, some of which associate with endothelial glycocalyx, and (3) enhance repair of damaged glycocalyx by (a) providing glycocalyx mimetics and (b) increasing the prevalence of glycocalyx scaffold for association and incorporation thereof.
Compositions and methods for treating endothelial glycocalyx include glucosamine, hyaluronan and/or fucoidan, and one or more antioxidants, such as superoxide dismutase, catalase, and/or polyphenol. The compositions improve vascular health by exhibiting beneficial synergistic effects on endothelial glycocalyx over the benefits of taking any single component alone or the sum of reported effects of the individual components. Specifically, components of the composition (1) enhance synthesis of new glycocalyx by (a) providing and (b) increasing production of glycocalyx precursors, (2) protecting existing glycocalyx against damage, such as by oxidation degradation, by (a) providing and (b) increasing production of antioxidants, some of which associate with endothelial glycocalyx, and (3) enhance repair of damaged glycocalyx by (a) providing glycocalyx mimetics and (b) increasing the prevalence of glycocalyx scaffold for association and incorporation thereof.
Compositions and methods for treating endothelial glycocalyx include glucosamine, hyaluronan and/or fucoidan, and one or more antioxidants, such as superoxide dismutase, catalase, and/or polyphenol. The compositions improve vascular health by exhibiting beneficial synergistic effects on endothelial glycocalyx over the benefits of taking any single component alone or the sum of reported effects of the individual components. Specifically, components of the composition (1) enhance synthesis of new glycocalyx by (a) providing and (b) increasing production of glycocalyx precursors, (2) protecting existing glycocalyx against damage, such as by oxidation degradation, by (a) providing and (b) increasing production of antioxidants, some of which associate with endothelial glycocalyx, and (3) enhance repair of damaged glycocalyx by (a) providing glycocalyx mimetics and (b) increasing the prevalence of glycocalyx scaffold for association and incorporation thereof.
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