Middle Tennessee State University

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IPC Class
A61P 31/10 - Antimycotics 7
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca 6
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings 5
A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone 4
A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine 3
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25 - Clothing; footwear; headgear 3
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16 - Paper, cardboard and goods made from these materials 1
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Registered / In Force 25

1.

ANTIMICROBIAL COMPOUNDS AND THE METHODS OF USE

      
Application Number 18695490
Status Pending
Filing Date 2022-09-30
First Publication Date 2024-11-28
Owner Middle Tennessee State University (USA)
Inventor
  • Bicker, Kevin Lee
  • Green, Robert Madison

Abstract

Peptoids, compositions thereof, and methods of using the peptoids. The peptoid may be an antimicrobial peptoid. In some embodiments, the peptoid may be used to treat or prevent a fungal infection, a biofilm produced from a fungal infection, or a combination thereof, in a vertebrate, such as a human or an animal, or in a plant. In some embodiments, the peptoid may be used to treat or prevent a bacterial infection, or biofilm produced from a bacterial infection, or a combination thereof, in a vertebrate, such as a human or an animal, or in a plant.

IPC Classes  ?

  • C07D 307/36 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
  • A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
  • A61P 31/04 - Antibacterial agents
  • A61P 31/10 - Antimycotics

2.

ANTIMICROBIAL COMPOUNDS AND THE METHOD OF USE

      
Application Number 18684007
Status Pending
Filing Date 2022-08-15
First Publication Date 2024-10-24
Owner Middle Tennessee State University (USA)
Inventor
  • Bicker, Kevin Lee
  • Green, Robert Madison

Abstract

Antimicrobial peptoids, compositions thereof, and methods of use. Antimicrobial peptoids or compositions thereof may be used to treat or prevent a fungal infection in a vertebrate. Antimicrobial peptoids or compositions thereof may be used to treat or prevent a fungal infection in a plant.

IPC Classes  ?

  • C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
  • A01N 37/46 - N-acyl derivatives
  • A01P 3/00 - Fungicides
  • A61K 38/00 - Medicinal preparations containing peptides
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61P 31/06 - Antibacterial agents for tuberculosis
  • A61P 31/10 - Antimycotics

3.

ANTIMICROBIAL COMPOUNDS AND THE METHODS OF USE

      
Document Number 03234054
Status Pending
Filing Date 2022-09-30
Open to Public Date 2023-04-06
Owner MIDDLE TENNESSEE STATE UNIVERSITY (USA)
Inventor
  • Bicker, Kevin Lee
  • Green, Robert Madison

Abstract

Peptoids, compositions thereof, and methods of using the peptoids. The peptoid may be an antimicrobial peptoid. In some embodiments, the peptoid may be used to treat or prevent a fungal infection, a biofilm produced from a fungal infection, or a combination thereof, in a vertebrate, such as a human or an animal, or in a plant. In some embodiments, the peptoid may be used to treat or prevent a bacterial infection, or biofilm produced from a bacterial infection, or a combination thereof, in a vertebrate, such as a human or an animal, or in a plant.

IPC Classes  ?

  • A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
  • A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
  • A61P 31/04 - Antibacterial agents
  • A61P 31/10 - Antimycotics
  • C07D 307/02 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
  • C07D 333/24 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

4.

ANTIMICROBIAL COMPOUNDS AND THE METHODS OF USE

      
Application Number US2022045350
Publication Number 2023/055999
Status In Force
Filing Date 2022-09-30
Publication Date 2023-04-06
Owner MIDDLE TENNESSEE STATE UNIVERSITY (USA)
Inventor
  • Bicker, Kevin, Lee
  • Green, Robert, Madison

Abstract

Peptoids, compositions thereof, and methods of using the peptoids. The peptoid may be an antimicrobial peptoid. In some embodiments, the peptoid may be used to treat or prevent a fungal infection, a biofilm produced from a fungal infection, or a combination thereof, in a vertebrate, such as a human or an animal, or in a plant. In some embodiments, the peptoid may be used to treat or prevent a bacterial infection, or biofilm produced from a bacterial infection, or a combination thereof, in a vertebrate, such as a human or an animal, or in a plant.

IPC Classes  ?

  • C07D 307/02 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
  • C07D 333/24 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
  • A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
  • A61P 31/04 - Antibacterial agents
  • A61P 31/10 - Antimycotics

5.

ANTIMICROBIAL COMPOUNDS AND THE METHOD OF USE

      
Document Number 03229500
Status Pending
Filing Date 2022-08-15
Open to Public Date 2023-02-23
Owner MIDDLE TENNESSEE STATE UNIVERSITY (USA)
Inventor
  • Bicker, Kevin Lee
  • Green, Robert Madison

Abstract

Antimicrobial peptoids, compositions thereof, and methods of use. Antimicrobial peptoids or compositions thereof may be used to treat or prevent a fungal infection in a vertebrate. Antimicrobial peptoids or compositions thereof may be used to treat or prevent a fungal infection in a plant.

IPC Classes  ?

  • A61K 38/08 - Peptides having 5 to 11 amino acids
  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids

6.

PRUSSIAN BLUE ZnO CARBON NANOTUBE COMPOSITE FOR MEASURING HYDROGEN PEROXIDE IN CANCER CELLS

      
Application Number 17792089
Status Pending
Filing Date 2021-01-06
First Publication Date 2023-02-23
Owner Middle Tennessee State University (USA)
Inventor
  • Chusuei, Charles
  • Pandey, Raja Ram

Abstract

A Prussian blue/zinc oxide-carbon nanotube composite is provided, the nanotube composite being selective and sensitive for detection of hydrogen peroxide, which is important for screening for early cancer detection, monitoring cardiovascular disease, detecting onset of food spoilage, and enzymatic reactions that produce hydrogen peroxide as a byproduct. Also provided are methods using said zinc oxide-carbon nanotube composite in which standard addition is used in combination with chronoamperometry detection to quantify the level of hydrogen peroxide in a biological sample.

IPC Classes  ?

  • G01N 27/327 - Biochemical electrodes
  • G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
  • G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
  • G01N 27/416 - Systems
  • G01N 27/48 - Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage

7.

ANTIMICROBIAL COMPOUNDS AND THE METHOD OF USE

      
Application Number US2022040309
Publication Number 2023/022969
Status In Force
Filing Date 2022-08-15
Publication Date 2023-02-23
Owner MIDDLE TENNESSEE STATE UNIVERSITY (USA)
Inventor
  • Bicker, Kevin Lee
  • Green, Robert Madison

Abstract

Antimicrobial peptoids, compositions thereof, and methods of use. Antimicrobial peptoids or compositions thereof may be used to treat or prevent a fungal infection in a vertebrate. Antimicrobial peptoids or compositions thereof may be used to treat or prevent a fungal infection in a plant.

IPC Classes  ?

  • A61K 38/08 - Peptides having 5 to 11 amino acids
  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids

8.

Compositions including ginsenoside 20(S)-Rg3 and methods of using ginsenoside 20(S)-Rg3 to inhibit alpha herpesvirus

      
Application Number 17338882
Grant Number 11980648
Status In Force
Filing Date 2021-06-04
First Publication Date 2021-12-09
Grant Date 2024-05-14
Owner MIDDLE TENNESSEE STATE UNIVERSITY (USA)
Inventor
  • Wright, Stephen
  • Smith, Shannon
  • Maynard, Karen
  • Altman, Elliot

Abstract

This disclosure describes a composition including the ginsenoside 20(S)-Rg3 (also referred to herein as Rg3) and methods of using such a composition. In some embodiments, the composition may be used to treat or prevent an alpha herpesvirus including, for example, herpes simplex virus (HSV)-1 and HSV-2. In some embodiments, the composition is substantially free of other ginsenosides.

IPC Classes  ?

  • A61K 36/258 - Panax (ginseng)
  • A61K 31/52 - Purines, e.g. adenine
  • A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
  • A61K 31/662 - Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
  • A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
  • A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
  • A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
  • A61P 31/22 - Antivirals for DNA viruses for herpes viruses

9.

PRUSSIAN BLUE ZNO CARBON NANOTUBE COMPOSITE FOR MEASURING HYDROGEN PEROXIDE IN CANCER CELLS

      
Application Number US2021012337
Publication Number 2021/142008
Status In Force
Filing Date 2021-01-06
Publication Date 2021-07-15
Owner MIDDLE TENNESSEE STATE UNIVERSITY (USA)
Inventor
  • Chusuei, Charles
  • Pandey, Raja Ram

Abstract

A Prussian blue/zinc oxide-carbon nanotube composite is provided, the nanotube composite being selective and sensitive for detection of hydrogen peroxide, which is important for screening for early cancer detection, monitoring cardiovascular disease, detecting onset of food spoilage, and enzymatic reactions that produce hydrogen peroxide as a byproduct. Also provided are methods using said zinc oxide-carbon nanotube composite in which standard addition is used in combination with chronoamperometry detection to quantify the level of hydrogen peroxide in a biological sample.

IPC Classes  ?

  • G02F 1/155 - Electrodes
  • G09G 3/16 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of a single character by selection from a plurality of characters, or by composing the character by combination of individual elements, e.g. segments by control of light from an independent source
  • G09G 3/38 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix by control of light from an independent source using electrochromic devices

10.

Assay for High-Throughput Identification of Therapeutic Compounds

      
Application Number 17083521
Status Pending
Filing Date 2020-10-29
First Publication Date 2021-04-22
Owner Middle Tennessee State University (USA)
Inventor
  • Bicker, Kevin L.
  • Fisher, Kevin J.
  • Corson, Ashley E.

Abstract

A solid supported branched linker assay system, including an alpha compound and a beta compounds reversibly tethered to a solid support; a branched linker coupled to the solid support that tethers the alpha and beta compounds to the solid support; the branched linker having two cleavable linkers that are chemically distinct from one another, wherein a first chemically distinct linker tethers the β compound to the branched linker and a second chemically distinct linker tethers the α compound to the branched linker; and at least two means for cleaving the chemically distinct linkers, wherein a first cleavage means is configured to selectively cleave a first chemically distinct linker and a second cleavage means is configured to selectively cleave a second chemically distinct linker.

IPC Classes  ?

  • C12Q 1/18 - Testing for antimicrobial activity of a material
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C07K 17/06 - Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
  • C07K 17/08 - Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer

11.

Therapeutic aurones

      
Application Number 17011311
Grant Number 11286245
Status In Force
Filing Date 2020-09-03
First Publication Date 2021-02-25
Grant Date 2022-03-29
Owner MIDDLE TENNESSEE STATE UNIVERSITY (USA)
Inventor
  • Stubblefield, Jeannie
  • Taylor, Zachary E.
  • Handy, Scott
  • Newsome, Anthony

Abstract

Substituted aurones were found to have antitrypanosomal, antifungal and immunomodulatory activity. The invention provides novel aurone compounds, pharmaceutical compositions, and methods encompassing medical and veterinary applications.

IPC Classes  ?

  • C07D 307/88 - Benzo [c] furansHydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
  • C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
  • A61K 31/4402 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
  • A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
  • A61K 31/404 - Indoles, e.g. pindolol
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 307/86 - Benzo [b] furansHydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
  • C07D 407/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
  • A61P 31/10 - Antimycotics
  • C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07F 17/02 - Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table

12.

AURONES AND METHODS OF USING AURONES TO TREAT TUBERCULOSIS

      
Application Number US2020030623
Publication Number 2020/223439
Status In Force
Filing Date 2020-04-30
Publication Date 2020-11-05
Owner
  • MIDDLE TENNESSEE STATE UNIVERSITY (USA)
  • UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (USA)
Inventor
  • Kong, Ying
  • Yang, Dong
  • Taylor, Zachary E.
  • Handy, Scott
  • Altman, Elliot

Abstract

Mycobacterium tuberculosisMtbMtb). In one aspect, this disclosure describes aurones including, for example, aurone 9504, aurone 9505, aurone 9501, aurone 9510, aurone AA2A, and aurone AA8, compositions including aurones, and methods of using aurones for treating or preventing tuberculosis.

IPC Classes  ?

  • A61K 31/00 - Medicinal preparations containing organic active ingredients

13.

Antifungal peptoids

      
Application Number 16718577
Grant Number 11369586
Status In Force
Filing Date 2019-12-18
First Publication Date 2020-06-18
Grant Date 2022-06-28
Owner Middle Tennessee State University (USA)
Inventor
  • Bicker, Kevin L.
  • Middleton, Madyson P.
  • Armstrong, Scott A.

Abstract

C. gattii or both.

IPC Classes  ?

  • C07C 259/06 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
  • A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 333/24 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • A61P 31/10 - Antimycotics

14.

LIGHTNING'S LOCKER ROOM

      
Serial Number 88708531
Status Registered
Filing Date 2019-11-27
Registration Date 2020-04-14
Owner Middle Tennessee State University, AKA MTSU ()
NICE Classes  ? 35 - Advertising and business services

Goods & Services

On-line retail store services featuring a wide-variety of consumer goods related to university athletic programs; Retail stores featuring a wide-variety of consumer goods related to university athletic programs

15.

Cis-gnetin H and trans-gnetin H as therapeutic agents

      
Application Number 16265789
Grant Number 11007169
Status In Force
Filing Date 2019-02-01
First Publication Date 2019-09-26
Grant Date 2021-05-18
Owner Middle Tennessee State University (USA)
Inventor
  • Gao, Ying
  • Altman, Elliot
  • Farone, Anthony
  • Park, Hyo

Abstract

The cis-isomer and trans-isomers of the plant-derived compound gnetin H are shown have anticancer properties, anti-inflammatory properties, and low toxicity. Therapeutic and prophylactic compositions that contain cis-gnetin H, trans-gnetin H, and derivatives thereof, as well as methods of making and using said compositions, are provided. cis-gnetin H and/or trans-gnetin H can be used in purified form or as a plant extract.

IPC Classes  ?

  • A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 36/65 - Paeoniaceae (Peony family), e.g. Chinese peony
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

16.

Therapeutic aurones

      
Application Number 16092916
Grant Number 10899727
Status In Force
Filing Date 2017-04-11
First Publication Date 2019-06-06
Grant Date 2021-01-26
Owner MIDDLE TENNESSEE STATE UNIVERSITY (USA)
Inventor
  • Taylor, Zachary E.
  • Handy, Scott
  • Farone, Anthony
  • Park, Hyo

Abstract

Substituted aurones were found to have antitrypanosomal, antifungal and immunomodulatory activity. The invention provides novel aurone compounds, pharmaceutical compositions, and methods encompassing medical and veterinary applications.

IPC Classes  ?

  • C07D 307/88 - Benzo [c] furansHydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
  • C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
  • A61K 31/4402 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
  • A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
  • A61K 31/404 - Indoles, e.g. pindolol
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07D 307/86 - Benzo [b] furansHydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
  • C07D 407/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
  • A61P 31/10 - Antimycotics
  • C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07F 17/02 - Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table

17.

2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione as a cancer therapeutic

      
Application Number 15534397
Grant Number 10993920
Status In Force
Filing Date 2015-12-09
First Publication Date 2017-12-21
Grant Date 2021-05-04
Owner Middle Tennessee State University (USA)
Inventor
  • Gao, Ying
  • Altman, Elliot

Abstract

Averrhoa carambola L., commonly known as starfruit. Pharmaceutical and nutraceutical compositions, as well as dietary supplements, are provided, as are methods of administration and treatment.

IPC Classes  ?

  • A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07C 50/04 - Benzoquinones, i.e. C6H4O2
  • C07C 50/32 - Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
  • A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
  • A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K 33/24 - Heavy metalsCompounds thereof
  • A23L 2/00 - Non-alcoholic beveragesDry compositions or concentrates thereforPreparation or treatment thereof
  • A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
  • A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
  • A23L 2/52 - Adding ingredients
  • A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
  • A23L 23/00 - SoupsSauces Preparation or treatment thereof
  • A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
  • A23L 7/10 - Cereal-derived products
  • A61K 36/185 - Magnoliopsida (dicotyledons)

18.

METHODS FOR TREATING ZIKA VIRAL INFECTIONS AND ASSOCIATED COMPLICATIONS

      
Application Number US2017029918
Publication Number 2017/189891
Status In Force
Filing Date 2017-04-27
Publication Date 2017-11-02
Owner MIDDLE TENNESSEE STATE UNIVERSITY (USA)
Inventor
  • Bodie, Neil, M.
  • Altman, Elliot
  • Park, Hyo

Abstract

Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, as well as methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation in viral infection, are described. For example, polypeptides and other compounds can be used to inhibit immune complex formation in a subject who has been diagnosed as having or is suspected of having a Zika virus infection.

IPC Classes  ?

  • C07K 7/00 - Peptides having 5 to 20 amino acids in a fully defined sequenceDerivatives thereof
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
  • C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
  • A61K 38/10 - Peptides having 12 to 20 amino acids

19.

THERAPEUTIC AURONES

      
Application Number US2017027038
Publication Number 2017/180644
Status In Force
Filing Date 2017-04-11
Publication Date 2017-10-19
Owner MIDDLE TENNESSEE STATE UNIVERSITY (USA)
Inventor
  • Stubblefield, Jeannie
  • Taylor, Zachary, E.
  • Handy, Scott
  • Farone, Mary
  • Mcclelland, Erin
  • Sutton, Caleb
  • Farone, Anthony
  • Park, Hyo
  • Araujo, Danielle
  • Newsome, Anthony

Abstract

Substituted aurones were found to have antitrypanosomal, antifungal and immunomodulatory activity. The invention provides novel aurone compounds, pharmaceutical compositions, and methods encompassing medical and veterinary applications.

IPC Classes  ?

  • A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
  • C07D 307/83 - Oxygen atoms
  • C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

20.

ASSAY FOR HIGH-THROUGHPUT lDENTIFICATION OF THERAPEUTIC COMPOUNDS

      
Application Number US2017023236
Publication Number 2017/165306
Status In Force
Filing Date 2017-03-20
Publication Date 2017-09-28
Owner
  • MIDDLE TENNESSEE STATE UNIVERSITY (USA)
  • MIDDLE TENNESSEE STATE UNIVIRSITY (USA)
Inventor
  • Bicker, Kevin, L.
  • Fisher, Kevin, J.
  • Corson, Ashley, E.

Abstract

A solid supported branched linker assay system, including an alpha compound and a beta compounds reversibly tethered to a solid support; a branched linker coupled to the solid support that tethers the alpha and beta compounds to the solid support; the branched linker having two cleavable linkers that are chemically distinct from one another, wherein a first chemically distinct linker tethers the β compound to the branched linker and a second chemically distinct linker tethers the a compound to the branched linker; and at least two means for cleaving the chemically distinct linkers, wherein a first cleavage means is configured to selectively cleave a first chemically distinct linker and a second cleavage means is configured to selectively cleave a second chemically distinct linker.

IPC Classes  ?

  • C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
  • C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof

21.

Assay for high-throughput identification of therapeutic compounds

      
Application Number 15464043
Grant Number 10851400
Status In Force
Filing Date 2017-03-20
First Publication Date 2017-09-21
Grant Date 2020-12-01
Owner Middle Tennessee State University (USA)
Inventor
  • Bicker, Kevin L.
  • Fisher, Kevin J.
  • Corson, Ashley E.

Abstract

A solid supported branched linker assay system, including an alpha compound and a beta compounds reversibly tethered to a solid support; a branched linker coupled to the solid support that tethers the alpha and beta compounds to the solid support; the branched linker having two cleavable linkers that are chemically distinct from one another, wherein a first chemically distinct linker tethers the β compound to the branched linker and a second chemically distinct linker tethers the α compound to the branched linker; and at least two means for cleaving the chemically distinct linkers, wherein a first cleavage means is configured to selectively cleave a first chemically distinct linker and a second cleavage means is configured to selectively cleave a second chemically distinct linker.

IPC Classes  ?

  • C12Q 1/18 - Testing for antimicrobial activity of a material
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C07K 17/06 - Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
  • C07K 17/08 - Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
  • C07K 5/083 - Tripeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
  • C07K 5/087 - Tripeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr

22.

CIS-AND TRANS-SUFFRUTICOSOL D AS THERAPEUTIC AGENTS

      
Application Number US2016044534
Publication Number 2017/019888
Status In Force
Filing Date 2016-07-28
Publication Date 2017-02-02
Owner
  • MIDDLE TENNESSEE STATE UNIVERSITY (USA)
  • INSTITUTE OF MEDICINAL PLANT DEVELOPMENT (China)
Inventor
  • Gao, Ying
  • Altman, Elliot

Abstract

The cis- and trans- isomers of the plant-derived compound suffruticosol D are shown to have anticancer properties. Therapeutic and prophylactic compositions that contain cis- or trans- suffruticosol D, as well as methods of making and using said compositions, are provided. The cis- or /ra«s-suffruticosol D can be used in purified form or as a plant extract.

IPC Classes  ?

23.

ANTI-TRYPANOSOMAL COMPOUNDS AND METHODS

      
Application Number US2016040112
Publication Number 2017/004215
Status In Force
Filing Date 2016-06-29
Publication Date 2017-01-05
Owner
  • MIDDLE TENNESSEE STATE UNIVERSITY (USA)
  • GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS (China)
Inventor
  • Dunlap, Norma
  • Newsome, Anthony
  • Stubblefield, Jeannie
  • Pathiranage, Anuradha

Abstract

Triterpenoid iridals and derivatives thereof have anti-trypanosomal activity.

IPC Classes  ?

  • A01N 43/04 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom

24.

METHODS FOR TREATING IMMUNE-MEDIATED VIRAL INFECTIONS

      
Application Number US2015067433
Publication Number 2016/106342
Status In Force
Filing Date 2015-12-22
Publication Date 2016-06-30
Owner MIDDLE TENNESSEE STATE UNIVERSITY (USA)
Inventor
  • Bodie, Neil, M.
  • Park, Hyo
  • Altman, Elliot

Abstract

Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, as well as methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation in viral infection, are described. For example, polypeptides and other compounds can be used to inhibit immune complex formation in a subject who has been diagnosed as having or is suspected of having an Ebola virus infection, a subject who has been diagnosed as having or is suspected of having an influenza virus infection, or a subject who has been diagnosed as having or is suspected of having a hepatitis virus infection.

IPC Classes  ?

  • C07K 7/00 - Peptides having 5 to 20 amino acids in a fully defined sequenceDerivatives thereof
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
  • A61K 38/10 - Peptides having 12 to 20 amino acids
  • C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses

25.

2-DODECYL-6-METHOXYCYCLOHEXA-2,5-DIENE-1,4-DIONE AS A CANCER THERAPEUTIC

      
Application Number US2015064785
Publication Number 2016/094554
Status In Force
Filing Date 2015-12-09
Publication Date 2016-06-16
Owner
  • MIDDLE TENNESSEE STATE UNIVERSITY (USA)
  • GUANGXI MEDICAL UNIVERSITY (China)
Inventor
  • Gao, Ying
  • Altman, Elliot

Abstract

2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD), as well as variants, derivatives, analogs, modifications, and conjugates thereof, are identified as therapeutic agents for treating or preventing human cancers and precancerous conditions. DMDD can be isolated from the root of Averrhoa carambola L., commonly known as starfruit. Pharmaceutical and nutraceutical compositions, as well as dietary supplements, are provided, as are methods of administration and treatment.

IPC Classes  ?

26.

CIS-GNETIN H AND TRANS-GNETIN H AS THERAPEUTIC AGENTS

      
Application Number US2015051424
Publication Number 2016/049012
Status In Force
Filing Date 2015-09-22
Publication Date 2016-03-31
Owner
  • MIDDLE TENNESSEE STATE UNIVERSITY (USA)
  • INSTITUTE OF MEDICINAL PLANT DEVELOPMENT (China)
Inventor
  • Gao, Ying
  • Altman, Elliot
  • Farone, Anthony
  • Park, Hyo

Abstract

The cis-isomer and trans-isomers of the plant-derived compound gnetin H are shown have anticancer properties, anti-inflammatory properties, and low toxicity. Therapeutic and prophylactic compositions that contain cis-gnetin H, trans-gnetin H, an derivatives thereof, as well as methods of making and using said compositions, are provided, cis-gnetin H and/or trans-gnetin H can be used in purified form or as a plant extract.

IPC Classes  ?

  • A61K 36/65 - Paeoniaceae (Peony family), e.g. Chinese peony

27.

I AM TRUE BLUE

      
Serial Number 85616005
Status Registered
Filing Date 2012-05-03
Registration Date 2013-06-25
Owner Middle Tennessee State University ()
NICE Classes  ? 41 - Education, entertainment, sporting and cultural services

Goods & Services

Educating at university or colleges; Education services in the nature of courses at the university level; Educational services, namely, conducting distance learning instruction at the University level; Providing a web site that features information on attending college and university with an emphasis on newly enrolled students

28.

1 FOR ALL

      
Serial Number 85027041
Status Registered
Filing Date 2010-04-30
Registration Date 2010-12-21
Owner MIDDLE TENNESSEE STATE UNIVERSITY ()
NICE Classes  ? 35 - Advertising and business services

Goods & Services

Promoting public awareness of the First Amendment to the United States Constitution and the five freedoms it protects

29.

MTSU

      
Serial Number 76286782
Status Registered
Filing Date 2001-07-18
Registration Date 2002-07-02
Owner Middle Tennessee State University ()
NICE Classes  ?
  • 25 - Clothing; footwear; headgear
  • 41 - Education, entertainment, sporting and cultural services

Goods & Services

Clothing, namely, athletic uniforms, caps, cheerleading uniforms, gym shorts, rainwear, shirts, sleepwear, socks, sweatshirts, and t-shirts Educational and entertainment services, namely, providing courses of instruction at the college and graduate levels; and entertainment in the nature of men's basketball, baseball, football, cross-country, golf, tennis and track events and games and women's basketball, cross country, golf, soccer, softball, tennis, track and volleyball games and events

30.

MT

      
Serial Number 76286784
Status Registered
Filing Date 2001-07-18
Registration Date 2002-08-13
Owner Middle Tennessee State University ()
NICE Classes  ?
  • 16 - Paper, cardboard and goods made from these materials
  • 25 - Clothing; footwear; headgear

Goods & Services

Paper goods and printed matter, namely spiral notebooks, ring binders, pens, pencils, and decals Clothing, namely, atheletic uniforms, caps, cheerleading uniforms, gym shorts, rainwear, shirts, sleepwear, sweatshirts, and tee-shirts

31.

MIDDLE TENNESSEE STATE UNIVERSITY

      
Serial Number 76286785
Status Registered
Filing Date 2001-07-18
Registration Date 2002-07-30
Owner Middle Tennessee State University ()
NICE Classes  ?
  • 25 - Clothing; footwear; headgear
  • 41 - Education, entertainment, sporting and cultural services

Goods & Services

Clothing, namely, atheletic uniforms, caps, gym shorts, shirts, sleepwear, sweatshirts, and t-shirts Educational and entertainment services, namely, providing courses of instruction at the college and graduate levels; and entertainment in the nature of men's basketball, baseball, football, cross-country, golf, tennis and track events and games and women's basketball, cross country, golf, soccer, softball, tennis, track and volleyball games and events