Abstract

There is disclosed an improved process for the production of L-carnitine, comprising the steps of: (a) reacting(S)-epichlorohydrin with trimethylamine hydrochloride in an organic solvent to yield L-3-chloro-2-hydroxylpropyl trimethylammonium chloride; (b) reacting the L-3-chloro-2-hydroxypropyl trimethylammonium chloride of step (a) with a source of cyanide to yield L-carnitinenitrile chloride; and (c) converting the L-carnitinenitrile chloride of step (b) to L-carnitine.

IPC Classes  ?

• C07C 227/02 - Formation of carboxyl groups in compounds containing amino groups, e.g. by oxidation of amino alcohols
• C07C 213/02 - Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
• C07C 213/10 - SeparationPurificationStabilisationUse of additives
• C07C 253/16 - Preparation of carboxylic acid nitriles by reaction of cyanides with lactones or compounds containing hydroxy groups or etherified or esterified hydroxy groups

Abstract

There is disclosed a process for the production of crystalline L-carnitine, comprising the step of crystallizing L-carnitine in a mixed solvent comprised of cyclohexane and an alcohol, wherein the alcohol is selected from the group consisting n-propanol, isobutanol, butanol, and a mixture thereof.

IPC Classes  ?

• C07C 227/42 - Crystallisation
• C08K 5/01 - Hydrocarbons
• C08K 5/05 - AlcoholsMetal alcoholates

Abstract

There is disclosed a process for the production of crystalline L-carnitine, comprising the step of crystallizing L-carnitine in a mixed solvent comprised of cyclohexane and an alcohol, wherein the alcohol is selected from the group consisting n-propanol, isobutanol, butanol, and a mixture thereof.

IPC Classes  ?

• C07C 227/42 - Crystallisation
• C07C 229/22 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Abstract

There is disclosed a process for the production of brivaracetam by converting an intermediate of the formula: There is disclosed a process for the production of brivaracetam by converting an intermediate of the formula: There is disclosed a process for the production of brivaracetam by converting an intermediate of the formula: to an intermediate of the formula: There is disclosed a process for the production of brivaracetam by converting an intermediate of the formula: to an intermediate of the formula: There is disclosed a process for the production of brivaracetam by converting an intermediate of the formula: to an intermediate of the formula: and then to brivaracetam; wherein R1 and R2 are each independently selected from the group consisting of hydrogen, alkali, alkaline earth metal, alkyl, and a mixture thereof.

IPC Classes  ?

• C07D 207/12 - Oxygen or sulfur atoms
• C07C 229/76 - Metal complexes of amino carboxylic acids
• C07C 233/36 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
• C07C 255/63 - Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton

Abstract

There is disclosed a process for the production of brivaracetam by converting an intermediate of the formula: (I) to an intermediate of the formula: (II) and then to brivaracetam; wherein R1 and R2 are each independently selected from the group consisting of hydrogen, alkali, alkaline earth metal, alkyl, and a mixture thereof.

IPC Classes  ?

• C07B 57/00 - Separation of optically-active organic compounds
• C07D 207/27 - 2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

Abstract

There is disclosed an improved process for the production of L-carnitine, comprising the steps of: (a) mixing an organic base with an acid solution comprised of L-carnitine to form an organic base salt of the acid, optionally in the presence of a solvent; (b) removing the organic base salt of step (a) to yield a solution comprised of L-carnitine; and (c) isolating the L-carnitine from the solution of step (b).

IPC Classes  ?

• C07C 227/18 - Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters

Abstract

There is disclosed an improved process for the production of L-carnitine, comprising the steps of: (a) mixing an organic base with an acid solution comprised of L-carnitine to form an organic base salt of the acid, optionally in the presence of a solvent; (b) removing the organic base salt of step (a) to yield a solution comprised of L-carnitine; and (c) isolating the L-carnitine from the solution of step (b).

IPC Classes  ?

• C07C 227/30 - Preparation of optical isomers
• C07C 227/32 - Preparation of optical isomers by stereospecific synthesis
• C07C 229/02 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
• C07C 229/22 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Abstract

There is disclosed an improved process for the production of L-carnitine, comprising a step of decolorizing L-carnitinenitrile and removing residual alkali cyanide from a solution of L-carnitinenitrile with an oxidant, wherein the oxidant is preferably hydrogen peroxide or sodium hypochlorite.

IPC Classes  ?

• C07C 227/02 - Formation of carboxyl groups in compounds containing amino groups, e.g. by oxidation of amino alcohols
• C07C 227/42 - Crystallisation

Abstract

There is disclosed an improved process for the production of L-carnitine, comprising a step of decolorizing L-carnitinenitrile and removing residual alkali cyanide from a solution of L-carnitinenitrile with an oxidant, wherein the oxidant is preferably hydrogen peroxide or sodium hypochlorite.

IPC Classes  ?

• C07C 229/02 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
• C07C 229/04 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
• C07C 227/30 - Preparation of optical isomers
• C07C 227/32 - Preparation of optical isomers by stereospecific synthesis
• C07C 229/22 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms