Abstract

Methods and pharmaceutical compositions are provided for treating idiopathic intracranial hypertension (III) and cluster headache, wherein a somatostatin mimetic formulated for intranasal administration is administered, including direct nose-to-brain administration.

IPC Classes  ?

• A61K 38/31 - Somatostatins
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/38 - CelluloseDerivatives thereof
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

Methods and therapeutic combinations are provided for treating idiopathic intracranial hypertension (IIH) and cluster headache, comprising administering a somatostatin mimetic such as octreotide formulated for direct nose-to-brain administration, and a carbonic anhydrase inhibitor such as topiramate or acetazolamide, at a dose level and/or dosing regimen lower than effective when administered alone.

IPC Classes  ?

• A61K 38/31 - Somatostatins
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/18 - Sulfonamides
• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61K 31/433 - Thiadiazoles
• A61K 31/54 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

Methods and pharmaceutical compositions are provided for treating idiopathic intracranial hypertension (IIH) and cluster headache, wherein a somatostatin mimetic formulated for intranasal administration is administered, including direct nose-to-brain administration.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 38/31 - Somatostatins
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

Methods and therapeutic combinations are provided for treating idiopathic intracranial hypertension (IIH) and cluster headache, comprising administering a somatostatin mimetic such as octreotide formulated for direct nose-to-brain administration, and a carbonic anhydrase inhibitor such as topiramate or acetazolamide, at a dose level and/or dosing regimen lower than effective when administered alone.

IPC Classes  ?

• A61K 9/12 - AerosolsFoams
• A61K 31/18 - Sulfonamides
• A61K 38/31 - Somatostatins
• A61P 7/10 - Antioedematous agentsDiuretics