Fibers including a polyurethane or a protein polyurethane alloy. The fibers include a core defined by the polyurethane or the protein polyurethane alloy. The fibers including a protein polyurethane alloy include a protein dissolved within a polyurethane. In some embodiments, the fibers can be made by wet spinning a blended mixture of the polyurethane or protein polyurethane alloy and an organic solvent. In alternative embodiments, the fibers can be made by wet spinning a blended mixture of the polyurethane or protein polyurethane alloy and an aqueous polyethylene oxide solution.
D01F 8/02 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from cellulose, cellulose derivatives, or proteins
D01F 6/70 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolycondensation products from polyurethanes
D01F 6/94 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds of other polycondensation products
D01F 8/16 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from synthetic polymers with at least one other macromolecular compound obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
D06P 1/39 - General processes of dyeing or printing textiles or general processes of dyeing leather, furs or solid macromolecular substances in any form, classified according to the dyes, pigments or auxiliary substances employed using acid dyes
Protein polyurethane alloys including one or more succinylated proteins dissolved within one or more polyurethanes. The protein polyurethane alloys may have one or more mechanical properties that are superior to the polyurethane in the absence of protein. The protein polyurethane alloys may be incorporated into a layered material including one or more protein polyurethane alloy layers.
SINGTEX INDUSTRIAL CO., LTD. (Taiwan, Province of China)
Inventor
Yaraghi, Nicholas Andrew
Broadbent, Samuel
Bates-Hennelly, Thomas Paul
Awad, Nicholas Alexander
Seth, Anuj
Chang, Li-Hsun
Abstract
22O measured according to JIS L 1092 hydrostatic pressure method test. In some embodiments, the protein polyurethane alloy can have a breathability of greater than 3,000 g/m2/24hr measured according to JIS L 1099 B1. The membranes can achieve these waterproofness and/or breathability characteristics at thicknesses less than or equal to about 200 microns.
Dyed materials comprising a textile with natural fibers comprising hydroxyl functional groups, a protein, a dye, and a cross-linker. The protein can be covalently linked to at least the natural fibers via the cross-linker. The dye can be bonded to the natural fibers, the cross-linker, the protein, or a combination thereof. The textiles can be dyed using an aqueous dyeing formulation comprising one or more proteins, one or more cross-linkers, and one or more dyes.
D06P 1/38 - General processes of dyeing or printing textiles or general processes of dyeing leather, furs or solid macromolecular substances in any form, classified according to the dyes, pigments or auxiliary substances employed using reactive dyes
D06P 1/39 - General processes of dyeing or printing textiles or general processes of dyeing leather, furs or solid macromolecular substances in any form, classified according to the dyes, pigments or auxiliary substances employed using acid dyes
D06P 5/00 - Other features in dyeing or printing textiles or dyeing leather, furs or solid macromolecular substances in any form
C07D 203/04 - Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
D06N 3/14 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof with macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds with polyurethanes
Materials comprising a protein polyurethane alloy comprising one or more proteins dissolved within one or more polyurethanes. The materials can be subjected to various leather and/or textile treatments to create described properties. For example, in some embodiments, the material can be dyed. As another example, in some embodiments, the material can be fatliquored.
D06N 3/14 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof with macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds with polyurethanes
C09J 175/00 - Adhesives based on polyureas or polyurethanesAdhesives based on derivatives of such polymers
11.
MELT-BLENDED THERMOPLASTIC PROTEIN ELASTOMER COMPOSITES
C14B 7/04 - Composite leathers by cementing or pressing together leather pieces, strips, or layersReinforcing or stiffening leather by means of reinforcing layers
D06N 3/12 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof with macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
12.
MELT-BLENDED THERMOPLASTIC PROTEIN ELASTOMER COMPOSITES
The present disclosure relates to thermoplastic protein elastomer compositions comprising protein, at least one reactive thermoplastic elastomer, and at least one softener, as well as composite materials made from these compositions. Methods of making and using the thermoplastic protein elastomer composite materials to produce engineered leather are also disclosed. In some embodiments, the protein is selected from the group consisting of: soy protein, cellulase, zein protein, egg white albumin, and pea protein; and wherein the protein and the thermoplastic elastomer are not covalently bound together. In some embodiments, the protein and the thermoplastic elastomer are present in co-continuous phases.
C14B 7/04 - Composite leathers by cementing or pressing together leather pieces, strips, or layersReinforcing or stiffening leather by means of reinforcing layers
D06N 3/12 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof with macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
C14C 13/00 - Manufacture of special kinds of leather, e.g. vellum
The present disclosure relates to compositions comprising collagen and hyaluronic acid, wherein the collagen is fully miscible with the hyaluronic acid. The present disclosure also relates to a composition comprising collagen, hyaluronic acid, and additional polymers, wherein the collagen is fully miscible with the hyaluronic acid and polymers. Methods of using the compositions described herein for medical and cosmetic treatments are also provided.
The present disclosure provides methods of treating cancer in a subject in need thereof, the method comprising contacting a cellular surface on the subject with an effective amount of a recombinant collagen fragment, including a fragment having a sequence identity of at least about 85% to the amino acid sequence set forth in SEQ ID NO: 1. Therapeutic biomaterials for use in the methods described herein are also provided.
D01F 6/70 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolycondensation products from polyurethanes
D01F 8/02 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from cellulose, cellulose derivatives, or proteins
D01F 8/04 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from synthetic polymers
16.
POLYURETHANE FIBERS AND METHODS OF MAKING THE SAME
Fibers including a polyurethane or a protein polyurethane alloy. The fibers include a core defined by the polyurethane or the protein polyurethane alloy. The fibers including a protein polyurethane alloy include a protein dissolved within a polyurethane. In some embodiments, the fibers can be made by wet spinning a blended mixture of the polyurethane or protein polyurethane alloy and an organic solvent. In alternative embodiments, the fibers can be made by wet spinning a blended mixture of the polyurethane or protein polyurethane alloy and an aqueous polyethylene oxide solution.
D01F 8/02 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from cellulose, cellulose derivatives, or proteins
D01F 8/04 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from synthetic polymers
D01F 6/70 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolycondensation products from polyurethanes
Coated fibers including a core fiber and a coating disposed over the core fiber. The coating can include a protein dissolved within a polyurethane. The coating can be dyed using, for example, an acid dye or a reactive dye. The coated fibers can be made by applying a coating solution including the protein dissolved within the polyurethane to the core fiber.
Protein polyurethane alloys including one or more succinylated proteins dissolved within one or more polyurethanes. The protein polyurethane alloys may have one or more mechanical properties that are superior to the polyurethane in the absence of protein. The protein polyurethane alloys may be incorporated into a layered material including one or more protein polyurethane alloy layers.
Protein polyurethane alloys including one or more succinylated proteins dissolved within one or more polyurethanes. The protein polyurethane alloys may have one or more mechanical properties that are superior to the polyurethane in the absence of protein. The protein polyurethane alloys may be incorporated into a layered material including one or more protein polyurethane alloy layers.
Protein polyurethane alloys including one or more proteins dissolved within one or more polyurethanes. The protein polyurethane alloy may have one or more mechanical properties that are superior to the polyurethane in the absence of protein. The protein polyurethane alloys may be incorporated into a layered material including one or more protein polyurethane alloy layers.
The present disclosure relates to thermoplastic collagen elastomer compositions comprising collagen, at least one reactive thermoplastic elastomer, and at least one softener, as well as composite materials made from these compositions. Methods of making and using the thermoplastic collagen elastomer composite materials to produce engineered leather are also disclosed.
D06N 3/10 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof with macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds with styrene-butadiene copolymerisation products
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
The present disclosure relates to a recombinant collagen, peptide fragments thereof, and sequence variants thereof. A novel Pichia pastoris strain for producing the recombinant collagen, fragments thereof, and sequence variants thereof, and methods of using the recombinant collagen, fragments, and sequence variants thereof are also provided. The present disclosure fulfills a need for environmentally friendly and safe alternatives for skincare.
The present disclosure relates to a recombinant collagen fragment having a molecular weight of about 55 kDa, and compositions comprising the recombinant collagen fragment. Methods of producing the recombinant collagen fragment and methods of treatment using the recombinant collagen fragment are also provided.
The present disclosure provides layered collagen materials comprising one or more collagen/polymer matrix layers. The collagen/polymer matrix layer(s) are formed of a collagen blended with one or more polymers. The collagen blended within the polymer(s) can be dissolved within the polymer(s). The one or more collagen/polymer matrix layers can be attached to a substrate layer, for example a fabric layer.
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 5/18 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by features of a layer containing foamed or specifically porous material
Protein-coated materials comprising a substrate, a first coating and a second protein coating, and methods for making these protein-coated materials are provided. The first coating can be a salt coating or a polymer coating. The protein coating can include a recombinant protein. The substrate can be, for example, a yarn, or a sheet material.
D06M 15/564 - Polyureas, polyurethanes or other polymers having ureide or urethane linksPrecondensation products forming them
D06M 13/53 - CoolingSteaming or heating, e.g. in fluidised bedsTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials with non-macromolecular organic compoundsSuch treatment combined with mechanical treatment combined with mechanical treatment with molten metals
Textiles, namely, fabrics made of biofabricated materials for textile use; knitted fabrics; products made from textiles, namely, place mats of textile, quilts of textile, table cloths of textile, fabric imitating animal skins, textile wall hangings, towels of textile; Textile fabrics for use in making clothing and household furnishings
Textiles, namely, fabrics made of biofabricated materials for textile use; knitted fabrics; products made from textiles, namely, place mats of textile, quilts of textile, table cloths of textile, fabric imitating animal skins, textile wall hangings, towels of textile; Textile fabrics for use in making clothing and household furnishings
Protein polyurethane alloys including one or more proteins dissolved within one or more polyurethanes. The protein polyurethane alloy may have one or more mechanical properties that are superior to the polyurethane in the absence of protein. The protein polyurethane alloys may be incorporated into a layered material including one or more protein polyurethane alloy layers.
Protein polyurethane alloys including one or more proteins dissolved within one or more polyurethanes. The protein polyurethane alloy may have one or more mechanical properties that are superior to the polyurethane in the absence of protein. The protein polyurethane alloys may be incorporated into a layered material including one or more protein polyurethane alloy layers.
Protein polyurethane alloys including one or more proteins dissolved within one or more polyurethanes. The protein polyurethane alloy may have one or more mechanical properties that are superior to the polyurethane in the absence of protein. The protein polyurethane alloys may be incorporated into a layered material including one or more protein polyurethane alloy layers.
22 - Rope, netting, tents, awnings, sails and sacks; padding and stuffing materials
Goods & Services
tents; tarpaulins; sails; Fibers, namely, textile fibers, synthetic fibers, semi-synthetic fibers; biofabricated fibers in the nature of textile fibers; fibers for textile use, namely, collagen-based fibers and collagen-coated textile fibers; textile fibers, namely, collagen-based fibers and collagen-coated textile fibers; ropes and strings; bioleather sails; sacks, namely, bivouac sacks being shelters and sacks for the transportation or storage of materials in bulk; padding, cushioning and stuffing materials, not of rubber, plastics or paper; fibers in the nature of a synthetic leather alternative fiber for further manufacture of fabrics, textiles, yarns, and carpet
39.
MONOMERIC PROTEINS FOR HYDROXYLATING AMINO ACIDS AND PRODUCTS
The disclosure herein provides a monomeric prolyl 4-hydroxylase. A microorganism including a monomeric prolyl 4-hydroxylase is provided. The disclosure provides a microorganism including a monomeric prolyl 4-hydroxylase; and another protein to be hydroxylated. A method for providing skincare benefits including applying the fusion protein of the present disclosure on skin is also taught.
The disclosure herein provides a monomeric prolyl 4-hydroxylase. A microorganism including a monomeric prolyl 4-hydroxylase is provided. The disclosure provides a microorganism including a monomeric prolyl 4-hydroxylase; and another protein to be hydroxylated. A method for providing skincare benefits including applying the fusion protein of the present disclosure on skin is also taught.
Bags, handbags. Textiles, namely, fabrics made of biofabricated materials
for textile use; knitted fabrics; products made from
textiles, namely, place mats of textile, quilts of textile,
table cloths of textile, textile fabric of animal skin
imitations, textile wall hangings, towels of textile.
42.
LEATHER-LIKE MATERIAL COMPRISING MELT-BLENDED COLLAGEN AND THERMOPLASTIC POLYMER
The present disclosure relates to thermoplastic collagen elastomer compositions comprising collagen, at least one reactive thermoplastic elastomer, and at least one softener, as well as composite materials made from these compositions. Methods of making and using the thermoplastic collagen elastomer composite materials to produce engineered leather are also disclosed.
C14B 7/04 - Composite leathers by cementing or pressing together leather pieces, strips, or layersReinforcing or stiffening leather by means of reinforcing layers
43.
LEATHER-LIKE MATERIAL COMPRISING MELT-BLENDED COLLAGEN AND THERMOPLASTIC POLYMER
The present disclosure relates to thermoplastic collagen elastomer compositions comprising collagen, at least one reactive thermoplastic elastomer, and at least one softener, as well as composite materials made from these compositions. Methods of making and using the thermoplastic collagen elastomer composite materials to produce engineered leather are also disclosed.
C14B 7/04 - Composite leathers by cementing or pressing together leather pieces, strips, or layersReinforcing or stiffening leather by means of reinforcing layers
C14C 13/00 - Manufacture of special kinds of leather, e.g. vellum
01 - Chemical and biological materials for industrial, scientific and agricultural use
18 - Leather and imitations of leather
22 - Rope, netting, tents, awnings, sails and sacks; padding and stuffing materials
Goods & Services
Proteins and bio-based polymers for use in the manufacture
of consumer products. Imitation leather made of biofabricated materials. Fibers made from protein and bio-based polymer for use in
the manufacture of consumer products.
(1) All-purpose carrying bags, duffle bags, crossbody bags; handbags.
(2) Textiles, namely, fabrics made of biofabricated materials for textile use; knitted fabrics; products made from textiles, namely, place mats of textile, quilts of textile, table cloths of textile, textile fabric of animal skin imitations, textile wall hangings, towels of textile.
01 - Chemical and biological materials for industrial, scientific and agricultural use
18 - Leather and imitations of leather
22 - Rope, netting, tents, awnings, sails and sacks; padding and stuffing materials
Goods & Services
(1) Proteins and bio-based polymers beads for use in the manufacture of consumer products, namely textiles, cosmetics, and pharmaceuticals
(2) Imitation leather made of biofabricated materials
(3) Synthetic and semi-synthetic fibers made from protein and bio-based polymer for use in the manufacture of consumer products, namely, textiles
Textiles, namely, fabrics made of biofabricated materials for textile use; knitted fabrics; products made from textiles, namely, place mats of textile, quilts of textile, table cloths of textile, fabric imitating animal skins, textile wall hangings, towels of textile
01 - Chemical and biological materials for industrial, scientific and agricultural use
22 - Rope, netting, tents, awnings, sails and sacks; padding and stuffing materials
Goods & Services
proteins and bio-based polymers for use in the manufacture of consumer products Synthetic and semi synthetic fibers made from protein and bio-based polymer for use in the manufacture of textile products
51.
COLLAGEN-INFUSED COMPOSITE MATERIALS AND METHODS OF MANUFACTURING THE SAME
The present disclosure provides a collagen-infused composite material comprising an optionally functionalized armature including a base substrate and one or more and non-woven substrates. The non-woven substrate(s) can be directly coupled to a topmost surface and/or bottommost surface of the base substrate. The material properties and/or collagen infusion capacities of the base substrate and the non-woven substrate(s) can be tailored to create a collagen-infused composite material with characteristics that mimic those of a natural leather. In some embodiments, the base substrate can be spacer fabric. In some embodiments, the armature can be functionalized to facilitate the crosslinking the collagen to the armature during one or more tanning processes.
The present disclosure provides a collagen-infused composite material comprising an optionally functionalized armature including a base substrate and one or more and non-woven substrates. The non-woven substrate(s) can be directly coupled to a topmost surface and/or bottommost surface of the base substrate. The material properties and/or collagen infusion capacities of the base substrate and the non-woven substrate(s) can be tailored to create a collagen-infused composite material with characteristics that mimic those of a natural leather. In some embodiments, the base substrate can be spacer fabric. In some embodiments, the armature can be functionalized to facilitate the crosslinking the collagen to the armature during one or more tanning processes.
Protein-coated materials comprising a substrate, a first coating and a second protein coating, and methods for making these protein-coated materials are provided. The first coating can be a salt coating or a polymer coating. The protein coating can include a recombinant protein. The substrate can be, for example, a yarn, or a sheet material.
The present disclosure provides layered collagen materials comprising one or more collagen/polymer matrix layers. The collagen/polymer matrix layer(s) are formed of a collagen blended with one or more polymers. The collagen blended within the polymer(s) can be dissolved within the polymer(s). The one or more collagen/polymer matrix layers can be attached to a substrate layer, for example a fabric layer.
The present disclosure provides layered collagen materials comprising one or more collagen/polymer matrix layers. The collagen/polymer matrix layer(s) are formed of a collagen blended with one or more polymers. The collagen blended within the polymer(s) can be dissolved within the polymer(s). The one or more collagen/polymer matrix layers can be attached to a substrate layer, for example a fabric layer.
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 5/18 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by features of a layer containing foamed or specifically porous material
56.
LAYERED COLLAGEN MATERIALS AND METHODS OF MAKING THE SAME
The present disclosure provides layered collagen materials comprising one or more collagen/polymer matrix layers. The collagen/polymer matrix layer(s) are formed of a collagen blended with one or more polymers. The collagen blended within the polymer(s) can be dissolved within the polymer(s). The one or more collagen/polymer matrix layers can be attached to a substrate layer, for example a fabric layer.
A composite material including mycelium fibers and proteins is described herein. The composite material can include a first protein substrate layer and a second mycelium layer, where the first and second layer are attached to each other. The composite material can include a first protein substrate layer, a second mycelium layer, and a third substrate layer, where the first layer and the second layer are attached to each other, and the second layer and third layer are attached to each other.
The disclosure herein provides a fusion protein comprising prolyl 4-hydroxylase alpha subunit (P4HA) and a soluble protein partner. A fusion protein comprising prolyl 4-hydroxylase alpha subunit (P4HA1) and prolyl 4-hydroxylase beta subunit (P4HB) is provided. A microorganism including a fusion protein comprising prolyl 4-hydroxylase alpha subunit-1 (P4HA1) and prolyl 4-hydroxylase beta subunit (P4HB) is provided. The disclosure provides a microorganism including a fusion protein comprising prolyl 4-hydroxylase alpha subunit-1 (P4HA1) and prolyl 4-hydroxylase beta subunit (P4HB); and another protein to be hydroxylated. A method for providing skincare benefits including applying the fusion protein of the present disclosure on skin is also taught.
The invention herein provides biofabricated leather materials, solutions comprising collagen that can be used to create biofabricated leather materials, articles comprising biofabricated leather materials, methods for making biofabricated materials, methods for applying biofabricated proteins to substrates and methods for making three dimensional biofabricated materials.
C14B 7/04 - Composite leathers by cementing or pressing together leather pieces, strips, or layersReinforcing or stiffening leather by means of reinforcing layers
60.
BIOFABRICATED LEATHER ARTICLES, AND METHODS THEREOF
The invention herein provides biofabricated leather materials, solutions comprising collagen that can be used to create biofabricated leather materials, articles comprising biofabricated leather materials, methods for making biofabricated materials, methods for applying biofabricated proteins to substrates and methods for making three dimensional biofabricated materials.
C14B 7/04 - Composite leathers by cementing or pressing together leather pieces, strips, or layersReinforcing or stiffening leather by means of reinforcing layers
C08H 1/06 - Macromolecular products derived from proteins derived from horn, hoofs, hair, skin, or leather
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B33Y 70/00 - Materials specially adapted for additive manufacturing
B33Y 80/00 - Products made by additive manufacturing
61.
THREE DIMENSIONALLY SHAPED BIOFABRICATED MATERIALS AND METHODS OF MANUFACTURE
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
62.
THREE DIMENSIONALLY SHAPED BIOFABRICATED MATERIALS AND METHODS OF MANUFACTURE
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
63.
Biofabricated material containing collagen fibrils
A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
D06N 7/00 - Flexible sheet materials not otherwise provided for, e.g. textile threads, filaments, yarns or tow, glued on macromolecular material
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B32B 15/02 - Layered products essentially comprising metal in a form other than a sheet, e.g. wire, particles
B32B 15/14 - Layered products essentially comprising metal next to a fibrous or filamentary layer
B32B 23/10 - Layered products essentially comprising cellulosic plastic substances next to a fibrous or filamentary layer
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
B32B 29/02 - Layered products essentially comprising paper or cardboard next to a fibrous or filamentary layer
B32B 3/26 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids
C14C 13/00 - Manufacture of special kinds of leather, e.g. vellum
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C14C 9/00 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes
C14C 9/02 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes using fatty or oily materials, e.g. fat liquoring
D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather
D01C 3/00 - Treatment of animal material, e.g. chemical scouring of wool
D04H 1/00 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
C14B 7/04 - Composite leathers by cementing or pressing together leather pieces, strips, or layersReinforcing or stiffening leather by means of reinforcing layers
C14C 13/00 - Manufacture of special kinds of leather, e.g. vellum
C08H 1/06 - Macromolecular products derived from proteins derived from horn, hoofs, hair, skin, or leather
C08L 89/06 - Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
D06N 3/12 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof with macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.
This invention relates to genetically engineered strains of yeast and methods, for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.
C12P 1/00 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of .alpha. ketoglutarate.
C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
C12P 1/02 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes by using fungi
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
69.
BIOFABRICATED LEATHER ARTICLES, AND METHODS THEREOF
The invention herein provides biofabricated leather materials, solutions comprising collagen that can be used to create biofabricated leather materials, articles comprising biofabricated leather materials applied to portions of a substrate in a pattern or a design such a lace like pattern, and/or that serve to join end portions of one or more substrates, e.g., to replace stitching and/or adhesives, and methods thereof.
D01F 11/02 - Chemical after-treatment of man-made filaments or the like during manufacture of cellulose, cellulose derivatives, or proteins
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
Engineered, reinforced leather materials (engineered leathers) including a composite of a fibrous matrix that has been tanned to allow crosslinking of the fibrous matrix to the collagen formed by cultured cells (e.g., fibroblasts). These engineered leathers may be referred to as fiber-reinforced biological tissue composites. Also described herein are methods of making such fiber-reinforced biological tissue composites.
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
C14C 3/06 - Mineral tanning using chromium compounds
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
12 - Land, air and water vehicles; parts of land vehicles
14 - Precious metals and their alloys; jewelry; time-keeping instruments
18 - Leather and imitations of leather
20 - Furniture and decorative products
22 - Rope, netting, tents, awnings, sails and sacks; padding and stuffing materials
23 - Yarns and threads for textile use
24 - Textiles and textile goods
25 - Clothing; footwear; headgear
26 - Small items for dressmaking; artifical flowers; false hair
27 - Floor and wall coverings
Goods & Services
(1) Collagen for use in manufacturing of a leather alternative.
(2) Phone cases, mobile phone cases, tablet and computer cases made of biofabricated leather.
(3) Coverings for vehicle seats and vehicle components, namely, fitted vehicle seat covers; vehicle seats; structural parts of automobiles, namely, automobile seats; coverings for automobile seats and automobile components, namely, fitted automotive seat covers; vehicle linings and coverings, namely, fitted covers for vehicles, fitted covers for vehicle steering wheels, fitted dashboard covers for vehicles, vehicle dashboards, gear shift covers; biofabricated leather vehicle linings and coverings, namely, fitted covers for vehicles, fitted covers for vehicle steering wheels, fitted dashboard covers for vehicles, vehicle dashboards, gear shift covers; linings and biofabricated leather linings for automobiles, namely, fitted vehicle covers for automobiles, fitted dashboard covers for vehicles, vehicle dashboards, gear shift covers, steering wheel covers for automobiles.
(4) Biofabricated leather watch bands and straps.
(5) Biofabricated leather being a collagen-based leather substitute; all-purpose carrying bags made of biofabricated leather, athletic bags made of biofabricated leather, backpacks made of biofabricated leather, travel bags made of biofabricated leather, change purses made of biofabricated leather, duffel bags made of biofabricated leather, luggage made of biofabricated leather; handbags made of biofabricated leather; handbags, purses and wallets; handbag, purses and wallets each made of biofabricated leather; backpacks, book bags, sports bags, bum bags; backpacks, book bags, sports bags, bum bags each made of biofabricated leather; suitcases; suitcases made of biofabricated leather; all-purpose carrying bags; weekend bags; bags and weekend bags each made of biofabricated leather; biofabricated leather for further manufacture.
(6) Bathroom furniture; bedroom furniture; dining room furniture; outdoor furniture; kitchen furniture; living room furniture; biofabricated bathroom furniture; biofabricated bedroom furniture; biofabricated dining room furniture; biofabricated living room furniture; biofabricated outdoor furniture; biofabricated kitchen furniture; bedroom furniture made of biofabricated leather; dining room furniture made of biofabricated leather; living room furniture made of biofabricated leather; kitchen furniture made of biofabricated leather.
(7) Fibers, namely, textile fibers, synthetic fibers, semi-synthetic fibers; biofabricated fibers in the nature of biofabricated leather textile fibers; biofabricated leather fibers; textile fibers; biofabricated leather stuffing fibers; biofabricated leather fibers for textile use; biofabricated leather fibers for nontextile use; biofabricated leather fibers for use in the manufacture of fabrics, textiles, yarns, carpets, clothing and apparel; ropes and strings; biofabricated leather ropes and strings; tents; biofabricated leather tents; tarpaulins; biofabricated leather tarpaulins; sails; biofabricated leather sails; sacks, namely, bivouac sacks being shelters, sacks for the transportation or storage of materials in bulk; biofabricated leather sacks, namely, bivouac sacks being shelters, sacks for the transportation or storage of materials in bulk; padding, cushioning and stuffing materials of biofabricated leather; biofabricated leather fibers in the nature of a leather alternative for further manufacture.
(8) Yarns; biofabricated leather yarns; biofabricated leather threads; biofabricated leather threads and yarns; biofabricated leather yarns for textile use; biofabricated leather yarns for non-textile use; biofabricated leather yarns for use in the manufacture of fabrics, textiles, yarns, carpets, clothing and apparel.
(9) Textiles, namely, biofabricated leather fabrics for textile use, knitted fabrics; biofabricated leather textiles in the nature of biofabricated leather fabrics; products made from textiles, namely, place mats of textile, quilts of textile, table cloths of textile, textile fabric of animal skin imitations, textile wall hangings, towels of textile; products made from biofabricated leather textiles, namely, place mats of textile, quilts of textile, table cloths of textile, textile fabric of animal skin imitations, textile wall hangings, towels of textile.
(10) Clothing, namely, shirts, pants, dresses, skirts, hats, scarves, belts; apparel, namely, shirts, pants, dresses, skirts, hats, scarves, belts; men's, women's and children's clothing and apparel, namely, shirts, pants, dresses, skirts, hats, scarves, belts; biofabricated leather clothing, namely, shirts, pants, dresses, skirts, hats, scarves, belts; biofabricated leather apparel, namely, shirts, pants, dresses, skirts, hats, scarves, belts; biofabricated leather men's, women's and children's clothing and apparel, namely, shirts, pants, dresses, skirts, hats, scarves, belts; Casual footwear, outdoor winter footwear, children's footwear, rain footwear, sports footwear, beach footwear, evening footwear; footwear made of biofabricated leather, namely, Casual footwear, outdoor winter footwear, children's footwear, rain footwear, sports footwear, beach footwear, evening footwear; athletic shoes and footwear; biofabricated leather athletic shoes and footwear.
(11) Lace and embroidery; ribbons and braid; biofabricated leather lace and embroidery; biofabricated leather ribbons and braid.
(12) Vinyl floor coverings, linoleum floor coverings, carpet tile floor coverings; biofabricated leather floor coverings.
The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.
Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins. The collagen or collagen-like proteins are isolated from animal sources or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
C14C 13/00 - Manufacture of special kinds of leather, e.g. vellum
A61L 15/32 - Proteins, polypeptidesDegradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
The invention is directed to a method for producing a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.
A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
The invention is directed to a method for producing a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.
A biofabricated material comprising a network of crosslinked collagen fibrils produced from recombinant collagen that contains substantially no 3-hydroxyproline residues is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
D06N 7/00 - Flexible sheet materials not otherwise provided for, e.g. textile threads, filaments, yarns or tow, glued on macromolecular material
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B32B 15/02 - Layered products essentially comprising metal in a form other than a sheet, e.g. wire, particles
B32B 15/14 - Layered products essentially comprising metal next to a fibrous or filamentary layer
B32B 23/10 - Layered products essentially comprising cellulosic plastic substances next to a fibrous or filamentary layer
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
B32B 29/02 - Layered products essentially comprising paper or cardboard next to a fibrous or filamentary layer
B32B 3/26 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids
D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather
C14C 13/00 - Manufacture of special kinds of leather, e.g. vellum
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C14C 9/00 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes
C14C 9/02 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes using fatty or oily materials, e.g. fat liquoring
D01C 3/00 - Treatment of animal material, e.g. chemical scouring of wool
D04H 1/00 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C14C 9/00 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes
C14C 9/02 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes using fatty or oily materials, e.g. fat liquoring
D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather
D01C 3/00 - Treatment of animal material, e.g. chemical scouring of wool
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
D04H 1/00 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D06N 7/00 - Flexible sheet materials not otherwise provided for, e.g. textile threads, filaments, yarns or tow, glued on macromolecular material
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B32B 15/02 - Layered products essentially comprising metal in a form other than a sheet, e.g. wire, particles
B32B 15/14 - Layered products essentially comprising metal next to a fibrous or filamentary layer
B32B 23/10 - Layered products essentially comprising cellulosic plastic substances next to a fibrous or filamentary layer
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
B32B 29/02 - Layered products essentially comprising paper or cardboard next to a fibrous or filamentary layer
B32B 3/26 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids
The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
D06N 7/00 - Flexible sheet materials not otherwise provided for, e.g. textile threads, filaments, yarns or tow, glued on macromolecular material
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B32B 15/02 - Layered products essentially comprising metal in a form other than a sheet, e.g. wire, particles
B32B 15/14 - Layered products essentially comprising metal next to a fibrous or filamentary layer
B32B 23/10 - Layered products essentially comprising cellulosic plastic substances next to a fibrous or filamentary layer
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
B32B 29/02 - Layered products essentially comprising paper or cardboard next to a fibrous or filamentary layer
B32B 3/26 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids
D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather
C14C 13/00 - Manufacture of special kinds of leather, e.g. vellum
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C14C 9/00 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes
C14C 9/02 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes using fatty or oily materials, e.g. fat liquoring
D01C 3/00 - Treatment of animal material, e.g. chemical scouring of wool
D04H 1/00 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins. The collagen or collagen-like proteins are isolated from animal sources or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
D06N 7/00 - Flexible sheet materials not otherwise provided for, e.g. textile threads, filaments, yarns or tow, glued on macromolecular material
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B32B 15/02 - Layered products essentially comprising metal in a form other than a sheet, e.g. wire, particles
B32B 15/14 - Layered products essentially comprising metal next to a fibrous or filamentary layer
B32B 23/10 - Layered products essentially comprising cellulosic plastic substances next to a fibrous or filamentary layer
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
B32B 29/02 - Layered products essentially comprising paper or cardboard next to a fibrous or filamentary layer
B32B 3/26 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids
D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather
C14C 13/00 - Manufacture of special kinds of leather, e.g. vellum
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C14C 9/00 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes
C14C 9/02 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes using fatty or oily materials, e.g. fat liquoring
D01C 3/00 - Treatment of animal material, e.g. chemical scouring of wool
D04H 1/00 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins which are recombinantly produced and which contain substantially no 3-hydroxyproline. The collagen or collagen-like proteins are isolated from animal sources, or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C14C 9/00 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes
C14C 9/02 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes using fatty or oily materials, e.g. fat liquoring
D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather
D01C 3/00 - Treatment of animal material, e.g. chemical scouring of wool
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
D04H 1/00 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D06N 7/00 - Flexible sheet materials not otherwise provided for, e.g. textile threads, filaments, yarns or tow, glued on macromolecular material
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B32B 15/02 - Layered products essentially comprising metal in a form other than a sheet, e.g. wire, particles
B32B 15/14 - Layered products essentially comprising metal next to a fibrous or filamentary layer
B32B 23/10 - Layered products essentially comprising cellulosic plastic substances next to a fibrous or filamentary layer
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
B32B 29/02 - Layered products essentially comprising paper or cardboard next to a fibrous or filamentary layer
B32B 3/26 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids
The invention is directed to a method for producing a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C14C 9/02 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes using fatty or oily materials, e.g. fat liquoring
C14C 9/00 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes
D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather
D01C 3/00 - Treatment of animal material, e.g. chemical scouring of wool
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
D04H 1/00 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D06N 7/00 - Flexible sheet materials not otherwise provided for, e.g. textile threads, filaments, yarns or tow, glued on macromolecular material
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B32B 3/26 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids
B32B 15/02 - Layered products essentially comprising metal in a form other than a sheet, e.g. wire, particles
B32B 15/14 - Layered products essentially comprising metal next to a fibrous or filamentary layer
B32B 23/10 - Layered products essentially comprising cellulosic plastic substances next to a fibrous or filamentary layer
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
B32B 29/02 - Layered products essentially comprising paper or cardboard next to a fibrous or filamentary layer
The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrilsand provides strength, elasticity and an aesthetic appearance to the composite material.
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
D06N 7/00 - Flexible sheet materials not otherwise provided for, e.g. textile threads, filaments, yarns or tow, glued on macromolecular material
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B32B 3/26 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids
D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C14C 9/00 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes
C14C 9/02 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes using fatty or oily materials, e.g. fat liquoring
D01C 3/00 - Treatment of animal material, e.g. chemical scouring of wool
D04H 1/00 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C14C 9/00 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes
C14C 9/02 - Impregnating leather for preserving, waterproofing, making resistant to heat or similar purposes using fatty or oily materials, e.g. fat liquoring
D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather
D01C 3/00 - Treatment of animal material, e.g. chemical scouring of wool
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
D04H 1/00 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D06N 7/00 - Flexible sheet materials not otherwise provided for, e.g. textile threads, filaments, yarns or tow, glued on macromolecular material
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B32B 15/02 - Layered products essentially comprising metal in a form other than a sheet, e.g. wire, particles
B32B 15/14 - Layered products essentially comprising metal next to a fibrous or filamentary layer
B32B 23/10 - Layered products essentially comprising cellulosic plastic substances next to a fibrous or filamentary layer
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
B32B 29/02 - Layered products essentially comprising paper or cardboard next to a fibrous or filamentary layer
B32B 3/26 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids
The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C08L 89/06 - Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
86.
METHOD FOR MAKING A BIOFABRICATED MATERIAL CONTAINING COLLAGEN FIBRILS
Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins. The collagen or collagen-like proteins are isolated from animal sources or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C08J 3/20 - Compounding polymers with additives, e.g. colouring
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
C08L 89/06 - Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
87.
BIOFABRICATED MATERIAL CONTAINING COLLAGEN FIBRILS
A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
Engineered, reinforced leather materials (engineered leathers) including a composite of a fibrous matrix that has been tanned to allow crosslinking of the fibrous matrix to the collagen formed by cultured cells (e.g., fibroblasts). These engineered leathers may be referred to as fiber-reinforced biological tissue composites. Also described herein are methods of making such fiber-reinforced biological tissue composites.
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
C14C 13/00 - Manufacture of special kinds of leather, e.g. vellum
89.
FABRICS AND METHODS OF MAKING THEM FROM CULTURED CELLS
Methods of using of natural or engineered proteins such as collagen to form tanned and/or crosslinked fibers suitable for a wide range of textile manufacturing processes, including non-woven, woven and knitted fabrics. In particular, described herein are methods of forming collagen fibers formed from cell-cultured materials by forming a solution of collagen, tanning agent and in some variations cross-linker, and shortly thereafter, extruding collagen fibers. Also described herein are collagen fibers formed by these methods.
D01D 5/00 - Formation of filaments, threads, or the like
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
D01H 1/30 - Driving or stopping arrangements for two or more machine elements possessing different characteristics but in operative association with two or more speedsDriving or stopping arrangements for two or more machine elements possessing different characteristics but in operative association with variable-speed arrangements
90.
FABRICS AND METHODS OF MAKING THEM FROM CULTURED CELLS
Methods of using of natural or engineered proteins such as collagen to form tanned and/or crosslinked fibers suitable for a wide range of textile manufacturing processes, including non-woven, woven and knitted fabrics. In particular, described herein are methods of forming collagen fibers formed from cell-cultured materials by forming a solution of collagen, tanning agent and in some variations cross-linker, and shortly thereafter, extruding collagen fibers. Also described herein are collagen fibers formed by these methods.
D01D 5/00 - Formation of filaments, threads, or the like
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
D01H 1/30 - Driving or stopping arrangements for two or more machine elements possessing different characteristics but in operative association with two or more speedsDriving or stopping arrangements for two or more machine elements possessing different characteristics but in operative association with variable-speed arrangements
Reinforced engineered biomaterials, and methods of making them, may be useful to form engineered leathers. Such engineered hides may be reinforced by encapsulating, and/or cross-linking to, a mesh and/or scaffold material, which may be a synthetic polymeric material. The resulting hide may include a stratified structure in which the mesh is held between layers of collagen-dense regions, where the collagen-dense regions overlaying the mesh following the contour of the mesh. Alternatively or additionally, the resulting hide may be a composite of a fibrous matrix that has been tanned to allow crosslinking of the fibrous matrix to the collagen formed by cultured cells. These engineered leathers may be referred to as fiber-reinforced biological tissue composites. The resulting materials may have superior durability and flexibility compared to other engineered materials and native leather, while retaining the look and feel of native leather.
D06N 3/00 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof
C14C 13/00 - Manufacture of special kinds of leather, e.g. vellum
C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
94.
DRIED FOOD PRODUCTS FORMED FROM CULTURED MUSCLE CELLS
Dehydrated, edible, high-protein food products formed of cultured muscle cells that are combined (e.g., mixed) with a hydrogel (e.g., a plant-derived polysaccharide) are described. These food products may be formed into a chip (e.g., snack chip), that has a protein content of greater than 50%. One or more flavorants may also be included.
Edible microcarriers, including microcarrier beads, microspheres and microsponges, appropriate for use in a bioreactor to culture cells that may be used to form a comestible engineered meat product. For example, the edible microcarriers described herein may include porous microcarriers that may be used to grow cells (e.g., smooth muscle cells) and may be included with the cells in the final engineered meat product, without requiring modification or removal of the cells from the microcarriers. In a particular example, the edible microcarriers may be formed of cross-linked pectin, such as pectin-thiopropionylamide (PTP), and RGD- containing polypeptide, such as thiolated cardosin A. Methods of forming edible microcarriers, methods of using the edible microcarriers to make engineered meat, and engineered meat including the edible microcarriers are also described herein.
Engineered animal skin, hide, and leather comprising a plurality of layers of collagen formed by cultured collagen-producing cells. Layers may be formed by cultured collagen-producing cells that are grown to confluence to form a sheet of collagen, the sheets are treated to prevent contractions, e.g., by decellularizing them with ethanol, and then the sheets are stacked and adhered together by seeding the region between the them with additional collagen-forming cells. Additional filler material may be added between the layers, such as reconstituted collagen or collagen pulp. Multiple layers may be stacked and adhered in this manner. Finally, the sheets may be treated to form leather, by modifying the collagen using a tanning (or a modified tanning) process.
Methods and devices that provide scalable extrusion of cultured cells for use in forming three-dimensional tissue structures. In particular, described herein are methods for preparing and continuously extruding a compacted multicellular body material that may be used to form bioengineered tissue structures. Also described are extrusion tip assemblies that are adapted to receive a suspension of cellular material, and can be used both to prepare the cellular material (e.g. compaction) and to extrude the cellular material in an efficient manner for forming tissue structures.
Methods of forming multicellular aggregates having cell-specific extracellular matrix (ECM), multicellular aggregates having cell-specific ECM, and methods for using these multicellular aggregates. In particular, described herein are methods of forming multicellular aggregates including forming a confluent layer of cells that is initially adhered to a substrate, removing the layer from the substrate and allowing it to ball up, and culturing the balled up layer on a non-adhesive substrate to form the multicellular aggregate.
Engineered animal skin, hide, and leather comprising a plurality of layers of collagen formed by cultured animal collagen-producing (e.g., skin) cells. Layers may be formed by elongate multicellular bodies comprising a plurality of cultured animal cells that are adhered and/or cohered to one another; wherein the elongate multicellular bodies are arranged to form a substantially planar layer for use in formation of engineered animal skin, hide, and leather. Further described herein are methods of forming engineered animal skin, hide, and leather utilizing said layers of animal collagen-producing cells.
