INTERFERENCE SYSTEM COMPRISING AT LEAST TWO SOURCES OF RADIATION EMITTING TWO BEAMS OF RADIATION INTERFERING IN A BODY PART OR REGION TO BE TREATED AND AT LEAST ONE NANOPARTICLE
A radiation heating system that includes at least two orientated radiation emitting elements that emit at least two radiation beams. There is a treated region of interference of the at least two radiation beams emitted by the at least two radiation emitting elements. The system also includes at least one nanoparticle comprised in the interference region.
A cryo-system for treating a body part of an individual by cryotherapy, which includes two parts. The first part is either i) a cryo-probe suitable for internal cooling, which includes a penetrating segment in communication with a cryogen source and is at least smaller than 1/10th of the body part's biggest volume and/or at least one dimension smaller than 1 cm or ii) a cryo-probe suitable for external cooling, which includes a non-penetrating segment in communication with a cryogen source. The second part is either i) an assembly of at least two nanoparticles bound to each other or associated with each other via binding or associating material or ii) at least one nanoparticle, which includes iron and at least one other metal than iron. The assembly of at least two nanoparticles or the at least one nanoparticle may be cooled by the cryo-probe or by switching on the cryo-probe.
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body
A61F 7/12 - Devices for heating or cooling internal body cavities
A method for removing at least one impurity from metal-based nanoparticles, including at least two heating steps. During step 1, the temperature of the nanoparticles is increased to a temperature T1, and is then maintained at T1 during a heating time that is included between 1 second and 20 years, where T1 is included between 50° C. and 300° C. During step 2, the temperature of the nanoparticles is increased to a temperature T2, and is then maintained at T2 during a heating time that is included between 1 second and 20 years, where T2 is included between 300° C. and 600° C.
High purity magnetosomes produced by magnetotactic bacteria, wherein the metallic composition of the magnetosome is characterized by a high level of iron purity, preferentially not achieved through a chemical synthesis. The high purity magnetosomes are further characterized by having a content of Cd, Pb, Ni, Co, Al, Mn, Zn, Li, and/or Cu.
An acoustic wave medical treatment of a body part of an individual in which nanoparticles are administered to the body part of the individual and the acoustic wave is applied on the body part, and the system for performing the treatment. The acoustic wave is sequentially applied on the body part, and/or the nanoparticles are magnetosomes. Also, the compositions that include these nanoparticles.
A composition including at least one nanoparticle or at least one chain of at least two nanoparticles, wherein each nanoparticle in the chain preferentially includes an iron oxide mineral core preferentially surrounded by a coating, wherein the composition further includes a cryo-protectant or protectant compound, wherein the volume occupied by the cryo-protectant or protectant compound in the composition is preferentially larger than the volume occupied by at least one chain in the composition, preferentially by a factor of at least 1, 2, 5, 10 or 103, wherein the percentage in mass of cryo-protectant or protectant compound in the composition is preferentially between 0.5 and 50%, wherein the composition is preferentially isotonic.
IRON OXIDE NANOPARTICLES COMPRISING TWO CENTERS OF ACTIVITIES OR FREE RADICAL CAPTURE/PRODUCTION FOR AN ENHANCED ACTIVITY AND COMBINING SPATIAL AND TEMPORAL SEQUENCES OF IRRADIATION USING THE NANOPARTICLES FOR AN IMPROVED TREATMENT OF DISEASES
A composition including nanoparticle(s) having an iron oxide mineral core surrounded by a coating and a cryo-protectant. The core includes a first center activity and/or the coating includes a second center of activity, each of which are either: (A) a radio sensitizer/amplifier of radiation, an acoustic sensitizer/amplifier of acoustic radiation, a sonosensitizer/amplificatory of acoustic wave, a particle radiation sensitizer/amplifier of particle radiation; or (B) an attenuator of radiation, of light radiation, of acoustic radiation or wave, of particle radiation. Also a method of using the composition for increasing production of free radicals or amplifying radiation during a sonodynamic, photodynamic or radiation therapy or exposure of a body part to a radiation in the treatment of diseases.
The invention relates to a composition comprising at least one nanoparticle or at least one chain of at least two nanoparticles, wherein each nanoparticle in the chain preferentially comprises an iron oxide mineral core preferentially surrounded by a coating, wherein the composition further comprises a cry o-protectant or protectant compound, wherein the volume occupied by the cryo-protectant or protectant compound in the composition is preferentially larger than the volume occupied by at least one chain in the composition, preferentially by a factor of at least 1, 2, 5, 10 or 103, wherein the percentage in mass of cryo-protectant or protectant compound in the composition is preferentially comprised between 0.5 and 50 %, wherein the composition is preferentially isotonic.
A cryo-system for treating a body part of an individual by cryotherapy, which includes two parts. The first part is either i) a cryo-probe suitable for internal cooling, which includes a penetrating segment in communication with a cryogen source and is at least smaller than 1/10th of the body part's biggest volume and/or at least one dimension smaller than 1 cm or ii) a cryo-probe suitable for external cooling, which includes a non-penetrating segment in communication with a cryogen source. The second part is either i) an assembly of at least two nanoparticles bound to each other or associated with each other via binding or associating material or ii) at least one nanoparticle, which includes iron and at least one other metal than iron. The assembly of at least two nanoparticles or the at least one nanoparticle may be cooled by the cryo-probe or by switching on the cryo-probe.
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61F 7/12 - Devices for heating or cooling internal body cavities
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body
10.
Magnetic field or radiation oscillating at several frequencies for improving efficacy and/or reducing toxicity of magnetic hyperthermia
Magnetic nanoparticles for use in a magnetic hyperthermia therapeutic treatment, prophylactic treatment, cosmetic treatment or diagnosis method, wherein the magnetic nanoparticles are administered to a body part of an individual and the body part is exposed to a magnetic field or radiation oscillating at a high frequency and at a medium and/or low frequency, wherein the high frequency is 1 MHz at the most, the medium frequency is lower than the high frequency, and the low frequency is lower than the high frequency and lower than the medium frequency when it is present.
A method for increasing the release of at least one compound, the compound being initially an initial compound bound to at least one initial nanoparticle, the initial compound bound to the initial nanoparticle forming an initial particle, wherein the initial particle includes at least one active ingredient, the method including at least one step of alteration of the initial particle and at least one step of physico-chemical disturbance of an altered particle resulting from the alteration.
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
12.
PARTICLE COMPRISING AT LEAST ONE FERRIMAGNETIC OR FERROMAGNETIC IRON OXIDE NANOPARTICLE ASSOCIATED WITH AT LEAST ONE COMPOUND FOR MEDICAL OR COSMETIC USE
The use, especially in vitro, of a particle including at least one ferrimagnetic or ferromagnetic iron oxide nanoparticle associated with at least one compound, in which the compound dissociates from the at least one ferrimagnetic or ferromagnetic iron oxide nanoparticle and/or chemically modifies itself, following a physicochemical disturbance applied on the particle, as a probe.
A non-pyrogenic preparation containing nanoparticles synthesized by magnetotactic bacteria for medical or cosmetic applications. The nanoparticles are constituted by a crystallized mineral central part including predominantly an iron oxide, as well as a surrounding coating without material from the magnetotactic bacteria.
A61K 8/99 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
The invention relates to a cry o-system for treating a body part of an individual by cryotherapy comprising two parts:a) a first part, which is a cryo-probe wherein:i) the cryo-probe is suitable for an internal cooling action as it comprises a penetrating segment which is in communication with a cryogen source and which is at least smaller than 1/10th of the biggest volume of said body part and/or has at least one dimension smaller than 1 cm;orii) the cryo-probe is suitable for an external cooling action as it comprises a non-penetrating segmentin communication with a cryogen source,andb) a second part, which is either:i) an assembly of at least two nanoparticles characterized in that this assembly comprises at least two nanoparticles bound to each other or associated with each other via binding or associating material, orii) at least one nanoparticle that comprises iron and at least one other metal than iron, wherein the assembly of at least two nanoparticles or the at least one nanoparticle is meant to be cooled down by the cryo-probe or by switching on the cryo-probe.
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
15.
Cryosystem comprising nanoparticles for treating a body part of an individual by cryotherapy
A cryo-system for treating a body part of an individual by cryotherapy, which includes two parts. The first part is either i) a cryo-probe suitable for internal cooling, which includes a penetrating segment in communication with a cryogen source and is at least smaller than 1/10th of the body part's biggest volume and/or at least one dimension smaller than 1 cm or ii) a cryo-probe suitable for external cooling, which includes a non-penetrating segment in communication with a cryogen source. The second part is either i) an assembly of at least two nanoparticles bound to each other or associated with each other via binding or associating material or ii) at least one nanoparticle, which includes iron and at least one other metal than iron. The assembly of at least two nanoparticles or the at least one nanoparticle may be cooled by the cryo-probe or by switching on the cryo-probe.
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61F 7/12 - Devices for heating or cooling internal body cavities
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body
16.
METHOD FOR INCREASING THE RELEASE OF MEDICAL COMPOUNDS FROM NANOPARTICLES BY AN ALTERATION STEP AND A PHYSICO-CHEMICAL DISTURBANCE STEP
The present invention relates to a method for increasing the release of at least one compound, said compound being initially an initial compound bound to at least one initial nanoparticle, said initial compound bound to said initial nanoparticle forming an initial particle, wherein the initial particle comprises at least one active ingredient, said method comprising at least one step of alteration of the initial particle and at least one step of physico-chemical disturbance of an altered particle resulting from the alteration.
A61K 47/52 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A composition including magnetic nanoparticles for use in the treatment of a tissue volume including pathological cells in an individual, wherein a portion only of the tissue volume is occupied by the magnetic nanoparticles upon administration of the composition to the individual and the magnetic nanoparticles are excited by radiation.
A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
A61N 1/40 - Applying electric fields by inductive or capacitive coupling
A method for producing high purity iron oxide nanoparticles using nanoparticle-producing cells, including: a) a pre-growth step that includes amplifying the nanoparticle-producing cell(s) in a pre-growth and/or fed-batch medium/media, and b) a growth step that includes amplifying the nanoparticle-producing cell(s) originating from the pre-growth step in a growth and/or fed-batch medium/media, wherein the pre-growth and/or growth and/or fed-batch medium/media comprise(s), per kilogram or liter of pre-growth and/or growth and/or fed-batch medium/media: i) no more than 0.005 gram of yeast extract, and ii) no more than 0.001 gram of CMR agent selected from boric acid and nitrilotriacetic acid, wherein the fed-batch medium when it is present is a medium that supplements the pre-growth and/or growth medium/media, and wherein more nanoparticles are produced in the growth step than in the pre-growth step.
C04B 35/26 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on ferrites
C04B 35/622 - Forming processesProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products
C12P 3/00 - Preparation of elements or inorganic compounds except carbon dioxide
19.
Cellular production of pure iron oxide nanoparticles
A method for producing high purity iron oxide nanoparticles using nanoparticle-producing cells, including: a) a pre-growth step that includes amplifying the nanoparticle-producing cell(s) in a pre-growth and/or fed-batch medium/media, and b) a growth step that includes amplifying the nanoparticle-producing cell(s) originating from the pre-growth step in a growth and/or fed-batch medium/media, wherein the pre-growth and/or growth and/or fed-batch medium/media comprise(s), per kilogram or liter of pre-growth and/or growth and/or fed-batch medium/media: i) no more than 0.005 gram of yeast extract, and ii) no more than 0.001 gram of CMR agent selected from boric acid and nitrilotriacetic acid, wherein the fed-batch medium when it is present is a medium that supplements the pre-growth and/or growth medium/media, and wherein more nanoparticles are produced in the growth step than in the pre-growth step.
C12P 3/00 - Preparation of elements or inorganic compounds except carbon dioxide
C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound
C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound
21.
Nanoparticles sequentially exposed to low intensity acoustic waves for medical or cosmetic applications
An acoustic wave medical treatment of a body part of an individual in which nanoparticles are administered to the body part of the individual and the acoustic wave is applied on the body part. The acoustic wave is sequentially applied on the body part, and/or the nanoparticles are magnetosomes. Also, compositions that include these nanoparticles.
Magnetosomes for use in a sequential laser radiation medical treatment, wherein the magnetosomes are administered to a body part of an individual. In a first step, the magnetosomes are irradiated by a laser radiation, and in a second step, the magnetosomes are irradiated by a laser radiation of lower power than in the first step or no laser irradiation of the magnetosomes is performed. The sequence of the first step and second step is repeated at least once.
A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
B82Y 25/00 - Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
23.
MAGNETIC NANOPARTICLES SEQUENTIALLY IRRADIATED BY LASER RADIATION FOR MEDICAL OR CHEMICAL OR BIOLOGICAL OR COSMETIC APPLICATIONS
This invention relates magnetosomes in a sequential laser radiation medical or biological or chemicalor cosmetic treatment, wherein the magnetosomes are administered to a body part of an individualand:- In a first step, the magnetosomes are irradiated by a laser radiation at a first power, and- In a second step, the magnetosomes are irradiated by a laser radiation of lower power than in the firststep or no laser irradiation of the magnetosomes is performed, andthe sequence comprising the first step and the second step is repeated at least once.
A non-pyrogenic preparation containing nanoparticles synthesized by magnetotactic bacteria for medical or cosmetic applications. The nanoparticles are constituted by a crystallized mineral central part including predominantly an iron oxide, as well as a surrounding coating without material from the magnetotactic bacteria.
A61K 8/99 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
G01N 33/84 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving inorganic compounds or pH
25.
Treatment of cancer or tumors induced by the release of heat generated by various chains of magnetosomes extracted from magnetotactic bacteria and submitted to an alternating magnetic field
A method for the treatment of tumor(s) or tumor cell(s) or cancer(s) in a subject in need by the generation of heat. The latter is produced by chains of magnetosomes extracted from whole magnetotactic bacteria and subjected to an alternating magnetic field. These chains of magnetosomes yield efficient antitumoral activity whereas magnetosomes unbound from the chains or kept within the whole bacteria produce poor or no antitumoral activity. The introduction of various chemicals such as chelating agents and/or transition metals within the growth medium of the bacteria improves the heating properties of the chains of magnetosomes. Moreover, the insertion of the chains of magnetosomes within a lipid vesicle is also suggested in order to favor their rotation in vivo and hence to improve their heating capacity. The vesicle can contain an antitumoral agent together with the chains of magnetosomes. In this case, the agent is released within the tumors by heating the vesicle.
C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound
A61K 9/00 - Medicinal preparations characterised by special physical form
Magnetic nanoparticles for use in a magnetic hyperthermia therapeutic treatment, prophylactic treatment or diagnosis method, wherein the magnetic nanoparticles are administered to a body part of an individual and the body part is exposed to a magnetic field oscillating at a high frequency and at a medium and/or low frequency, wherein the high frequency is 1 MHz at the most, the medium frequency is lower than the high frequency, and the low frequency is lower than the high frequency and lower than the medium frequency when it is present.
This invention relates to nanoparticles for use in an acoustic wave medical treatment of a body part of an individual, wherein nanoparticles are administered to the body part of the individual and the acoustic wave is applied on the body part, wherein the acoustic wave is sequentially applied on the body part, and/or, the nanoparticles are magnetosomes.
This invention concerns magnetic nanoparticles for use in a magnetic hyperthermia therapeutic treatment, prophylactic treatment or diagnosis method, wherein the magnetic nanoparticles are administered to a body part of an individual and the body part is exposed to a magnetic field oscillating at a high frequency and at a medium and/or low frequency, wherein the high frequency is 1 MHz at the most, the medium frequency is lower than the high frequency, and the low frequency is lower than the high frequency and lower than the medium frequency when it is present.
Disclosed is a composition including magnetic nanoparticles for use in the treatment of a tissue volume including pathological cells in an individual, wherein a portion only of the tissue volume is occupied by the magnetic nanoparticles upon administration of the composition to the individual and the magnetic nanoparticles are excited by radiations.
A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
A61N 1/40 - Applying electric fields by inductive or capacitive coupling
A non-pyrogenic preparation containing nanoparticles synthesized by magnetotactic bacteria for medical or cosmetic applications. The nanoparticles are constituted by a crystallized mineral central part including predominantly an iron oxide, as well as a surrounding coating without material from the magnetotactic bacteria.
A61K 8/99 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
G01N 33/84 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving inorganic compounds or pH
31.
Treatment of cancer or tumor induced by the release of heat generated by various chains of magnetosomes extracted from magnetotactic bacteria and submitted to an alternating magnetic field
A method for the treatment of tumor(s), tumor cell(s), cancer(s) in a subject by the generation of heat. The latter is produced by chains of magnetosomes extracted from whole magnetotactic bacteria and subjected to an alternating magnetic field. These chains of magnetosomes yield efficient antitumoral activity whereas magnetosomes unbound from the chains or kept within the whole bacteria produce poor or no antitumoral activity. The introduction of various chemicals such as chelating agents and/or transition metals within the growth medium of the bacteria improves the heating properties of the chains of magnetosomes. Moreover, the insertion of the chains of magnetosomes within a lipid vesicle is also suggested in order to favor their rotation in vivo and hence to improve their heating capacity. The vesicle can contain an antitumoral agent together with the chains of magnetosomes, and the agent is released within the tumors by heating the vesicle.
C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 9/00 - Medicinal preparations characterised by special physical form
PARTICLE COMPRISING AT LEAST ONE FERRIMAGNETIC OR FERROMAGNETIC IRON OXIDE NANOPARTICLE ASSOCIATED WITH AT LEAST ONE COMPOUND FOR MEDICAL OR COSMETIC USE
The invention relates to the use, particularly in vitro, of a particle as a probe, said particle comprising: at least one ferrimagnetic or ferromagnetic iron oxide nanoparticle (NANOF) associated with at least one compound, in which the compound breaks away from the iron oxide nanoparticle and/or is altered chemically following a physico-chemical disturbance exerted on the particle.
The present invention relates to an apyrogenic preparation containing nanoparticles synthesised by magnetotactic bacteria for medical or cosmetic applications. The nanoparticles according to the invention consist of a central crystallised mineral portion mostly comprising an iron oxide, and a peripheral coating not comprising material originating from magnetotactic bacteria.
C12P 1/04 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes by using bacteria
C12P 3/00 - Preparation of elements or inorganic compounds except carbon dioxide
34.
Treatment of cancer or tumors induced by the release of heat generated by various chains of magnetosomes extracted from magnetotactic bacteria and submitted to an alternating magnetic field
A method for the treatment of tumor(s) or tumor cell(s) or cancer(s) in a subject in need by the generation of heat. The latter is produced by chains of magnetosomes extracted from whole magnetotactic bacteria and subjected to an alternating magnetic field. These chains of magnetosomes yield efficient antitumoral activity whereas magnetosomes unbound from the chains or kept within the whole bacteria produce poor or no antitumoral activity. The introduction of various chemicals such as chelating agents and/or transition metals within the growth medium of the bacteria improves the heating properties of the chains of magnetosomes. Moreover, the insertion of the chains of magnetosomes within a lipid vesicle is also suggested in order to favor their rotation in vivo and hence to improve their heating capacity. The vesicle can contain an antitumoral agent together with the chains of magnetosomes. In this case, the agent is released within the tumors by heating the vesicle.
C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 9/00 - Medicinal preparations characterised by special physical form
In this disclosure, we describe a method for the treatment of tumor(s) or tumor cell(s) or cancer(s) in a subject in need by the generation of heat. The latter is produced by chains of magnetosomes extracted from whole magnetotactic bacteria and subjected to an alternative magnetic field. These chains of magnetosomes yield efficient antitumoral activity whereas magnetosomes unbound from the chains or kept within the whole bacteria produce poor or no antitumoral activity. The introduction of various chemicals such as chelating agents and/or transition metals within the growth medium of the bacteria improves the heating properties of the chains of magnetosomes. Moreover, the insertion of the chains of magnetosomes within a lipid vesicle is also suggested in order to favor their rotation in vivo and hence to improve their heating capacity. The vesicle can contain an antitumoral agent together with the chains of magnetosomes. In this case, the agent is released within the tumors by heating the vesicle.
patents
