Among other things, there are disclosed embodiments of devices used for minimally-invasive treatments, such as treatment of mitral valves. In a system for placing an annuloplasty belt around the heart, embodiments for tensioning a suture associated with the belt are provided, as are embodiments of a suture lock for holding the suture with the applied tension. A delivery device that permits placement and tensioning of such a belt and activation of the suture lock in one procedure is also disclosed. Methods for making and using these features are also disclosed.
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
The disclosure relates to interventional medical devices, such as sizing catheters, useful in the sizing of body vessels for various purposes, such as subsequent implantation of intraluminal medical devices. The disclosure also relates to methods of determining a sizing dimension of a body vessel at an area of interest, methods of implanting an intraluminal medical device at an area of interest in a body vessel, and methods of making intraluminal medical devices.
A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
There are shown and described embodiments of a closure device for closing holes in tissue, for example in the right atrial appendage. The closure device in particular embodiments includes first and second mesh closure members and a tether or stem connecting them. Embodiments of a delivery device for the closure device are also described.
A61B 17/10 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for applying or removing wound clamps; Wound clamp magazines
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
4.
Storage devices, loading devices, delivery systems, kits, and associated methods
Storage devices, loading devices, delivery systems, kits, and associated methods for implantable medical devices are described. An example embodiment of a storage device includes a storage member, a first cap, and a second cap. The storage member has a first end, a second end, and a main body that defines a first opening, a second opening, a passageway, a separating wall, and a plurality of holes. The passageway has a first portion and a second portion. The first portion extends from the first end of the storage member to the separating wall and the second portion extends from the second end of the storage member to the separating wall. Each hole of the plurality of holes extends through the separating wall and provides access between the first portion and the second portion. Each of the first and second caps is releasably attached to the storage member.
A61F 2/00 - Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61B 50/30 - Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
Among other things, there are disclosed embodiments of belts or bands that can be used in treatments for tricuspid valve regurgitation. In some embodiments, such belts may be heat-set in a particular configuration to effectively decrease tricuspid annulus when deployed around the atrioventricular groove. Embodiments include one or more tensioning sutures for applying cinching or tightening to belts when deployed, and structure for effectively distributing force during such tightening.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
7.
Access devices, treatment devices, and kits useful for performing treatment under magnetic resonance imaging and related methods
Example access devices, treatment devices, and kits useful in performing treatment under magnetic resonance imaging and related methods are described. An example access device includes an elongate tubular member formed of an MRI compatible material and moveable between a first, unexpanded configuration and a second, expanded configuration. The elongate tubular member has a central lengthwise axis, a proximal end, a distal end, an axial length, and a main body that defines a circumferential wall, a lumen, a proximal opening, a distal opening, and a main body opening. The main body opening is arranged in a spiral relative to the lengthwise axis and extends circumferentially along the circumferential wall. The main body opening extends along the entire axial length of the elongate tubular member from the proximal end to the distal end.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G01R 33/563 - Image enhancement or correction, e.g. subtraction or averaging techniques of moving material, e.g. flow-contrast angiography
8.
CELL TISSUE PROCESSING APPARATUS, SYSTEMS, METHODS, AND PRODUCTS
Material processing apparatus, systems, methods, and products are described. An example of a material processing apparatus includes a holding member, a base, a tensioning member, an actuator, and a first inner member. The holding member defines a holding member passageway. The base is attached to the holding member. The tensioning member is partially disposed within the holding member passageway. The tensioning member defines a tensioning member passageway. The tensioning member is moveable relative to the holding member between a first position and a second position. The actuator is attached to the tensioning member and is moveable in a first direction and a second direction. Movement of the actuator results in movement of the tensioning member between its first position and second position. The first inner member is adapted to be disposed within the tensioning member passageway.
Differential pressure material processing systems, apparatus, methods, and products are described. An example embodiment of a differential pressure material processing system includes a tank, a holding member, and a sheet of tissue disposed within the holding member. The holding member defines a first holding member chamber and a second holding member chamber. The first holding member chamber has a first pressure when a fluid is disposed within the first holding member chamber. The second holding member chamber has a second pressure when a fluid is disposed within the second holding member chamber. The second pressure is different than the first pressure.
THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services (USA)
Inventor
Gittard, Shaun Davis
Hardy, Gregory James
Sigmon, Jr., John C.
Newkirk, Jeremy T.
Havel, William J.
Fearnot, Neal E.
Rogers, Toby
Ratnayaka, Kanishka
Lederman, Robert L.
Abstract
Among other things, there is disclosed structure and methods for maintaining access to a location in the body while reducing or eliminating the potential for pulling an access device (e.g. a catheter) back through an opening. An introducer sheath includes a distal indented portion and a balloon, so that once placed in a desired location through tissue, the balloon can be inflated to anchor the sheath against retraction. In particular embodiments, structure and methods for accessing the pericardial cavity via the right atrial appendage are shown.
A61B 17/02 - Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
Storage devices, loading devices, delivery systems, kits, and associated methods for implantable medical devices are described. An example embodiment of a storage device includes a storage member, a first cap, and a second cap. The storage member has a first end, a second end, and a main body that defines a first opening, a second opening, a passageway, a separating wall, and a plurality of holes. The passageway has a first portion and a second portion. The first portion extends from the first end of the storage member to the separating wall and the second portion extends from the second end of the storage member to the separating wall. Each hole of the plurality of holes extends through the separating wall and provides access between the first portion and the second portion. Each of the first and second caps is releasably attached to the storage member.
A61F 2/00 - Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61B 50/30 - Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
Among other things, there are disclosed embodiments of belts or bands that can be used in treatments for tricuspid valve regurgitation. In some embodiments, such belts may be heat-set in a particular configuration to effectively decrease tricuspid annulus when deployed around the atrioventricular groove. Embodiments include one or more tensioning sutures for applying cinching or tightening to belts when deployed, and structure for effectively distributing force during such tightening. Embodiments of tensioning members, protective members, and devices and methods for open-surgical placement (e.g. around a heart for annuloplasty) are also disclosed.
Among other things, there are disclosed embodiments of belts or bands that can be used in treatments for tricuspid valve regurgitation. In some embodiments, such belts may be heat-set in a particular configuration to effectively decrease tricuspid annulus when deployed around the atrioventricular groove. Embodiments include one or more tensioning sutures for applying cinching or tightening to belts when deployed, and structure for effectively distributing force during such tightening. Embodiments of tensioning members, protective members, and devices and methods for open-surgical placement (e.g. around a heart for annuloplasty) are also disclosed.
Among other things, there are disclosed embodiments of devices used for minimally-invasive treatments, such as treatment of mitral valves. In a system for placing an annuloplasty belt around the heart, embodiments for tensioning a suture associated with the belt are provided, as are embodiments of a suture lock for holding the suture with the applied tension. A delivery device that permits placement and tensioning of such a belt and activation of the suture lock in one procedure is also disclosed. Methods for making and using these features are also disclosed.
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
15.
CELL TISSUE PROCESSING APPARATUS, SYSTEMS, METHODS, AND PRODUCTS
Material processing apparatus, systems, methods, and products are described. An example of a material processing apparatus includes a holding member, a base, a tensioning member, an actuator, and a first inner member. The holding member defines a holding member passageway. The base is attached to the holding member. The tensioning member is partially disposed within the holding member passageway. The tensioning member defines a tensioning member passageway. The tensioning member is moveable relative to the holding member between a first position and a second position. The actuator is attached to the tensioning member and is moveable in a first direction and a second direction. Movement of the actuator results in movement of the tensioning member between its first position and second position. The first inner member is adapted to be disposed within the tensioning member passageway.
Material processing apparatus, systems, methods, and products are described. An example of a material processing apparatus includes a holding member, a base, a tensioning member, an actuator, and a first inner member. The holding member defines a holding member passageway. The base is attached to the holding member. The tensioning member is partially disposed within the holding member passageway. The tensioning member defines a tensioning member passageway. The tensioning member is moveable relative to the holding member between a first position and a second position. The actuator is attached to the tensioning member and is moveable in a first direction and a second direction. Movement of the actuator results in movement of the tensioning member between its first position and second position. The first inner member is adapted to be disposed within the tensioning member passageway.
There are shown and described embodiments of a closure device for closing holes in tissue, for example in the right atrial appendage. The closure device in particular embodiments includes first and second mesh closure members and a tether or stem connecting them. Embodiments of a delivery device for the closure device are also described.
A61B 17/10 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for applying or removing wound clamps; Wound clamp magazines
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
18.
DIFFERENTIAL PRESSURE MATERIAL PROCESSING SYSTEMS, APPARATUS, METHODS, AND PRODUCTS
Differential pressure material processing systems, apparatus, methods, and products are described. An example embodiment of a differential pressure material processing system includes a tank, a holding member, and a sheet of tissue disposed within the holding member. The holding member defines a first holding member chamber and a second holding member chamber. The first holding member chamber has a first pressure when a fluid is disposed within the first holding member chamber. The second holding member chamber has a second pressure when a fluid is disposed within the second holding member chamber. The second pressure is different than the first pressure.
Storage devices, loading devices, delivery systems, kits, and associated methods for implantable medical devices are described. An example embodiment of a storage device includes a storage member, a first cap, and a second cap. The storage member has a first end, a second end, and a main body that defines a first opening, a second opening, a passageway, a separating wall, and a plurality of holes. The passageway has a first portion and a second portion. The first portion extends from the first end of the storage member to the separating wall and the second portion extends from the second end of the storage member to the separating wall. Each hole of the plurality of holes extends through the separating wall and provides access between the first portion and the second portion. Each of the first and second caps is releasably attached to the storage member.
A61F 2/00 - Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61B 50/30 - Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
Among other things, there are disclosed embodiments of devices used for minimally- invasive treatments, such as treatment of mitral valves. In a system for placing an annuloplasty belt around the heart, embodiments for tensioning a suture associated with the belt are provided, as are embodiments of a suture lock for holding the suture with the applied tension. A delivery device that permits placement and tensioning of such a belt and activation of the suture lock in one procedure is also disclosed. Methods for making and using these features are also disclosed.
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
21.
PERCUTANEOUS, ULTRASOUND-GUIDED INTRODUCTION OF MEDICAL DEVICES
Described are methods and systems and system components useful for percutaneously delivering or retrieving vascular implant devices, such as filters, utilizing intravenous ultrasound (IVUS) imaging alone or in combination with external (e.g. transabdominal) ultrasound or other imaging technology. Implants deliverable by such systems, such as vena cava or other vascular filters, can have two or more echogenic markers spaced at such a distance that they are separately discernible by IVUS and/or external ultrasound imaging.
Among other things, there are shown embodiments of locking mechanisms for holding sutures in tension. Such devices may be used with implants that use or require sutures, and are easily locked remotely. In particular embodiments, a lock includes a housing member, a pin member at least partially within the housing member, and a spring biasing the pin member into the housing member. The pin member includes a gripping portion, and has a retracted condition and a locked condition. When retracted, a suture can move through the housing member and around the gripping portion of the pin member. When locked, the gripping portion of the pin member engages the suture and presses it against the interior of the housing member.
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
Among other things, there is disclosed structure and methods for maintaining access to a location in the body while reducing or eliminating the potential for pulling an access device (e.g. a catheter) back through an opening. An introducer sheath includes a distal indented portion and a balloon, so that once placed in a desired location through tissue, the balloon can be inflated to anchor the sheath against retraction. In particular embodiments, structure and methods for accessing the pericardial cavity via the right atrial appendage are shown.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
Among other things, there are disclosed embodiments of belts or bands that can be used in treatments for tricuspid valve regurgitation. In some embodiments, such belts may be heat-set in a particular configuration to effectively decrease tricuspid annulus when deployed around the atrioventricular groove. Embodiments include one or more tensioning sutures for applying cinching or tightening to belts when deployed, and structure for effectively distributing force during such tightening.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
Among other things, there are disclosed embodiments of belts or bands that can be used in treatments for tricuspid valve regurgitation. In some embodiments, such belts may be heat-set in a particular configuration to effectively decrease tricuspid annulus when deployed around the atrioventricular groove. Embodiments include one or more tensioning sutures for applying cinching or tightening to belts when deployed, and structure for effectively distributing force during such tightening.
Described are medical products, methods, and cryogenic bags or other containers suitable for storing and/or transporting and/or processing cellular compositions and other related materials. In certain aspects, the contents of such cryogenic bags may be warmed, mixed, and applied to a patient. Medical products described herein find particular use in treating diseased and/or damaged tissue such as in wound repair and/or bone repair. Related methods of manufacture are also described.
There are shown and described embodiments of a closure device for closing holes in tissue, for example in the right atrial appendage. The closure device in particular embodiments includes first and second mesh closure members and a tether or stem connecting them. Embodiments of a delivery device for the closure device are also described.
A61B 17/10 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for applying or removing wound clamps; Wound clamp magazines
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
There are shown and described embodiments of a closure device for closing holes tissue, for example in the right atrial appendage. The closure device in particular embodiments includes first and second mesh closure members and a tether or stem connecting them. Embodiments of a delivery device for the closure device are also described.
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
Among other things, there is shown a system for filling vials with fluid that maintains a localized sterile zone around the filling location. In particular embodiments, the sterile zone is provided by a manifold having an internal space to which clean air is supplied. One or more filling assemblies are attached to the manifold. Vials enter the sterile zone and are filled within it. Additional structure, such as coverings for vials, are disclosed to assist in maintaining sterility.
B65B 55/02 - Sterilising, e.g. of complete packages
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
30.
Catheter systems and methods useful for cell therapy
Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.
A filling and sealing system is provided for efficiently filling a series of individual vials with therapeutic liquids. In particular embodiments, the system includes a filling zone or station, a sealing zone or station, an unloading zone or station, and electronic controls.
B65B 3/04 - Methods of, or means for, filling the material into the containers or receptacles
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
B65B 51/14 - Applying or generating heat or pressure or combinations thereof by reciprocating or oscillating members
B65B 7/16 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
B65B 7/02 - Closing containers or receptacles deformed by, or taking-up shape of, contents, e.g. bags, sacks
B65B 39/04 - Nozzles, funnels or guides for introducing articles or materials into containers or wrappers having air-escape, or air-withdrawal, passages
B65B 39/12 - Nozzles, funnels or guides for introducing articles or materials into containers or wrappers movable towards, or away from, container or wrapper during filling or depositing
B65B 51/10 - Applying or generating heat or pressure or combinations thereof
A filling and sealing system is provided for efficiently filling a series of individual vials with therapeutic liquids. In particular embodiments, the system includes a filling zone or station, a sealing zone or station, an unloading zone or station, and electronic controls.
B65B 51/14 - Applying or generating heat or pressure or combinations thereof by reciprocating or oscillating members
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
B65B 7/16 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
Intravascular devices and systems useful for blocking the opening of an aneurysm or a vessel branch are disclosed. In some aspects, the disclosure provides arrangements that align a covering material of a stent graft with an opening in the vessel wall before, during, and/or after expansion of the stent graft within the vasculature of a patient. In some instances, systems and devices include a sheath with a side aperture arranged to align a portion of the sheath and/or a portion of a stent graft contained within the sheath with the mouth of an aneurysm. Similarly, the present disclosure also provides embodiments in which the stent graft comprises an aligning member arranged to align the stent graft and/or a sheath with the mouth of an aneurysm. Other embodiments are disclosed.
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61F 2/97 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve the outer sleeve being splittable
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61B 17/22 - Surgical instruments, devices or methods, e.g. tourniquets for removing obstructions in blood vessels, not otherwise provided for
A61F 2/90 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
A61F 2/86 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure
A61F 2/856 - Single tubular stent with side portal passage
34.
Over-the-wire ultrasound system with torque-cable driven rotary transducer
Disclosed are embodiments of devices and methods for imaging the inside of a body part, such as a blood vessel. In particular embodiments, a catheter has a chamber within which is a transducer. A wire guide channel extends throughout the length of the catheter. The transducer is rotatable about the wire guide channel and the transducer is driven by a cable or other device that is connected to a motor which is located outside the catheter. In one form, a torque cable connects the transducer to the motor. In other embodiments, a pusher piece having a plurality of lumens is positioned in the catheter. Each of the lumens is sized to receive a cable, wire, and/or flushing fluid. The lumens maintain the orientation and separation of the cables, wires, and/or to flushing fluid.
Devices and methods for obtaining a real-time, three-dimensional image of a body part, particularly a blood vessel. A catheter has a chamber in its tip. The chamber contains an ultrasound transducer and reflector which generally face each other and rotate about a common axis. The transducer element on the transducer and the reflective face on the reflector are both tilted off-axis. The difference in angular velocity generally creates a phase shift between the transducer and the reflective face. The phase shift allows the transducer and the reflective face to actively scan a three-dimensional volume that is generally bounded interiorly by a hyperboloid and exteriorly by the effective range of the ultrasound beam. The transducer and reflector may rotate at constant speeds or nonconstant speeds as well in the same direction or in opposite directions.
Disclosed are embodiments of devices and methods for imaging the inside of a body part, such as a blood vessel. In particular embodiments, a catheter has a chamber within which is a transducer. A wire guide channel extends throughout the length of the catheter. The transducer is rotatable about the wire guide channel and the transducer is driven by a cable or other device that is connected to a motor which is located outside the catheter. In one form, a torque cable connects the transducer to the motor. In other embodiments, a pusher piece having a plurality of lumens is positioned in the catheter. Each of the lumens is sized to receive a cable, wire, and/or flushing fluid. The lumens maintain the orientation and separation of the cables, wires, and/or flushing fluid.
Devices and methods for obtaining a real-time, three-dimensional image of a body part, particularly a blood vessel. A catheter has a chamber in its tip. The chamber contains an ultrasound transducer and reflector which generally face each other and rotate about a common axis. The transducer element on the transducer and the reflective face on the reflector are both tilted off-axis. The difference in angular velocity generally creates a phase shift between the transducer and the reflective face. The phase shift allows the transducer and the reflective face to actively scan a three-dimensional volume that is generally bounded interiorly by a hyperboloid and exteriorly by the effective range of the ultrasound beam. The transducer and reflector may rotate at constant speeds or nonconstant speeds as well in the same direction or in opposite directions.
Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.
Arrangements and methods for delivering bioactive agents and/or cells into an extended volume of tissue are disclosed. In one embodiment, a cell-delivering needle arrangement has a tube positioned within a tube and fixedly attached to a wall thereof. In one exemplary method, a cell-delivering needle is advanced into tissue, a suspension of cells is passed through a first lumen and out of side ports, and a suspension of cells is passed through a second lumen and out of a distal opening. Other embodiments are disclosed.
A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
A61M 5/32 - Syringes - Details - Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
Described in one aspect is a multi-cell or multi-chambered container for sealing various materials such as therapeutic or diagnostic agents, animal or human tissue, tissue samples, specimens, blood, genetic material, or any other material. The container includes seals formed by folding the wall of the elongate body transverse to the interior of the elongate body and maintaining the folded wall portions adjacent one another or joining them together. In another aspect, the container disclosed may be made according to a method involving creating multiple seals at various locations along the elongate body thus creating sealed voids or cells between the seals within the elongate body.
Described in one aspect is a multi-cell or multi-chambered container for sealing various materials such as therapeutic or diagnostic agents, animal or human tissue, tissue samples, specimens, blood, genetic material, or any other material. The container includes seals formed by folding the wall of the elongate body transverse to the interior of the elongate body and maintaining the folded wall portions adjacent one another or joining them together. In another aspect, the container disclosed may be made according to a method involving creating multiple seals at various locations along the elongate body thus creating sealed voids or cells between the seals within the elongate body.
There are disclosed embodiments of devices and methods for imaging the inside of a body part, particularly a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a linear motor, a shaft or filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
Among other things, there are disclosed embodiments of a valve implant that in particular examples are implantable within a blood vessel, which include a first set of elongate members, a second set of elongate members, and a hood affixed to the first set of elongate members. The first set of elongate members is resiliently deformable, and their distal ends are flared radially outward. The distal ends of the second set of elongate members are distal to the ends of the first set of elongate members. The hood is affixed to the first set of elongate members, and seals against the interior wall of the blood vessel in an expanded configuration. When blood flows from the proximal to the distal side of the valve implant, it presses on the hood, compressing the first set of elongate members, breaking the seal.
Described are embodiments of devices and methods for imaging a body conduit, such as a blood vessel. In particular embodiments, the catheter has a chamber within which is a transducer mounted to a pivot mechanism. A coil provides a pivot force to the transducer. A magnet is attached to the transducer and is receptive of a torque applied by a magnetic field produced by energizing of the coil. A driving mechanism receives an impact from the pivot member and causes the pivot mechanism to rotate about a rotation axis.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
G01S 7/52 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group
Intravascular devices and systems useful for blocking the opening of an aneurysm or a vessel branch are disclosed. In some aspects, the disclosure provides arrangements that align a covering material of a stent graft with an opening in the vessel wall before, during, and/or after expansion of the stent graft within the vasculature of a patient. In some instances, systems and devices include a sheath with a side aperture arranged to align a portion of the sheath and/or a portion of a stent graft contained within the sheath with the mouth of an aneurysm. Similarly, the present disclosure also provides embodiments in which the stent graft comprises an aligning member arranged to align the stent graft and/or a sheath with the mouth of an aneurysm. Other embodiments are disclosed.
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61F 2/90 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
A61F 2/97 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve the outer sleeve being splittable
46.
Guide members and associated apparatuses useful for intravascular ultrasound procedures
Described are guidewires having at least one echolucent segment, and associated apparatuses and methods. The guidewires can be combined with devices equipped with intravascular ultrasound probes and used to effectively image regions during procedures underway in the vascular environment. The echolucent segment can have one or more echogenic markers to enable detection of the segment and/or relative movement of the segment using intravascular ultrasound.
Described are guidewires having at least one echolucent segment, and associated apparatuses and methods. The guidewires can be combined with devices equipped with intravascular ultrasound probes and used to effectively image regions during procedures underway in the vascular environment. The echolucent segment can have one or more echogenic markers to enable detection of the segment and/or relative movement of the segment using intravascular ultrasound.
There are disclosed embodiments of devices and methods for ultrasound imaging, for example of the inside of a body part such as a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a second motor operating a shaft or a filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
G10K 11/00 - Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
G10K 11/35 - Sound-focusing or directing, e.g. scanning using mechanical steering of transducers
A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
49.
COMPARTMENTED CRYOPRESERVATION CONTAINER AND USES THEREOF
Described are medical products, methods, and cryogenic bags or other containers suitable for storing and/or transporting and/or processing cellular compositions and other related materials. In certain aspects, the contents of such cryogenic bags may be warmed, mixed, and applied to a patient. Medical products described herein find particular use in treating diseased and/or damaged tissue such as in wound repair and/or bone repair. Related methods of manufacture are also described.
Described are medical products, methods, and cryogenic bags or other containers suitable for storing and/or transporting and/or processing cellular compositions and other related materials. In certain aspects, the contents of such cryogenic bags may be warmed, mixed, and applied to a patient. Medical products described herein find particular use in treating diseased and/or damaged tissue such as in wound repair and/or bone repair. Related methods of manufacture are also described.
Described are medical products, methods, and cryogenic bags or other containers suitable for storing and/or transporting and/or processing cellular compositions and other related materials. In certain aspects, the contents of such cryogenic bags may be warmed, mixed, and applied to a patient. Medical products described herein find particular use in treating diseased and/or damaged tissue such as in wound repair and/or bone repair. Related methods of manufacture are also described.
Among other things, there is disclosed structure and methods for registering images obtained through internal (e.g. intravascular) ultrasound devices. Embodiments of a device with a rotating ultrasound beam is provided, with a wall of the device being anisotropic in ultrasound passage. As examples, a cable opaque to ultrasound is attached along the wall of the device, so that the ultrasound beam at the location of the cable is blocked, reflected or scattered. As another example, a thin film of metallic material is placed on or in the wall to allow a portion of the beam to be blocked or attenuated. The imaging system recognizes the changes to the signals made by the anisotropic wall, and registers successive images according to those changes.
A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
G01S 7/52 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group
G10K 11/35 - Sound-focusing or directing, e.g. scanning using mechanical steering of transducers
G10K 11/00 - Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
An injection device for injecting a medicant into a plurality of tissue sites in a patient for a selected treatment is constructed and arranged such that the number of tissue sites is the total number for the selected treatment thereby requiring a single positioning step. The injection device includes a body having a syringe and a control linkage, the syringe including a plurality of barrels, and a cooperating plunger array including a plurality of plungers. Each barrel receives a corresponding plunger. The injection device further includes a plurality of injection needles connected to the syringe wherein one injection needle is connected to each barrel, a multi-lumen tip, a shaft connected to the multi-lumen tip and extending between said multi-lumen tip and said body. The control linkage is connected to each needle so as to move each needle between a deployed injection position and a retracted position.
A61M 5/32 - Syringes - Details - Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
Disclosed are embodiments of devices and methods for imaging the inside of a body part, such as a blood vessel. In particular embodiments, a catheter has a chamber within which is a transducer. A wire guide channel extends throughout the length of the catheter. The transducer is rotatable around the wire guide channel.
Disclosed are embodiments of devices and methods for imaging the inside of a body part, such as a blood vessel. In particular embodiments, a catheter has a chamber within which is a transducer. A wire guide channel extends throughout the length of the catheter. The transducer is rotatable around the wire guide channel.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
A61B 1/018 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor for receiving instruments
56.
CELL-SEEDED COMPOSITIONS AND METHODS USEFUL FOR TREATING BONE REGIONS
Compositions and methods for treating diseased or damaged bone, preferably ischemic and/or necrotic bone, include the use of a combination of endothelial progenitor cells and mesenchymal stem cells, desirably also in conjunction with a collagenous extracellular matrix tissue. Methods for preparation of such compositions are also described.
Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.
Compositions and methods for treating diseased or damaged bone, preferably ischemic and/or necrotic bone, include the use of a combination of endothelial progenitor cells and mesenchymal stem cells, desirably also in conjunction with a collagenous extracellular matrix tissue. Methods for preparation of such compositions are also described.
Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.
Disclosed are embodiments of methods and devices for providing enhanced echogenicity to medical devices. The method includes rolling an impression roller having a plurality of protrusions and an outer surface against a medical device. The protrusions create depressions in the surface of the medical device. A guide roller forms a ridge of the depression into the depression to create a lobe. The lobe forms a pocket between a bottom surface of the depression and the lobe.
Methods and apparatus are provided for treating tissue with apparatus that includes an priming portion for initiating a healing response in the tissue to be treated, and which delivers a bioactive agent during or after preparing tissue adjacent the apparatus, as by generating or aiding a healing, regeneration or repair response in the tissue. The priming portion may comprise an abrasive surface, fluid ejection ports, and/or stimulation by electrical, thermal, or light energy.
There are disclosed embodiments of devices and methods for imaging the inside of a body part, particularly a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a linear motor, a shaft or filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.
Disclosed are embodiments of devices and methods for providing enhanced echogenicity to medical devices. An echogenic feature is formed in the shape of a pyramidal reuleaux triangle. A lobe is constructed at a rim of an echogenic feature to create a pocket between the lobe and a bottom surface of the feature. A test fixture is disclosed which provides a method for obtaining quantifiable echogenicity data of medical devices.
There are disclosed embodiments of devices and methods for imaging the inside of a body part, particularly a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a linear motor, a shaft or filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.
Methods and apparatus are provided for treating tissue with apparatus that includes an priming portion for initiating a healing response in the tissue to be treated, and which delivers a bioactive agent during or after preparing tissue adjacent the apparatus, as by generating or aiding a healing, regeneration or repair response in the tissue. The priming portion may comprise an abrasive surface, fluid ejection ports, and/or stimulation by electrical, thermal, or light energy.
A61B 18/24 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Hand-pieces therefor with a catheter
66.
Internal ultrasound assembly with port for fluid injection
There are disclosed embodiments of devices and methods for imaging the inside of a body part, particularly a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a linear motor, a shaft or filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
There are disclosed embodiments of devices and methods for imaging the inside of a body part, particularly a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a linear motor, a shaft or filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.
Disclosed are embodiments of methods and devices for providing enhanced echogenicity to medical devices. The method includes rolling an impression roller having a plurality of protrusions and an outer surface against a medical device. The protrusions create depressions in the surface of the medical device. A guide roller forms a ridge of the depression into the depression to create a lobe. The lobe forms a pocket between a bottom surface of the depression and the lobe.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
Disclosed are embodiments of devices and methods for providing enhanced echogenicity to medical devices. An echogenic feature is formed in the shape of a pyramidal reuleaux triangle. A lobe is constructed at a rim of an echogenic feature to create a pocket between the lobe and a bottom surface of the feature. A test fixture is disclosed which provides a method for obtaining quantifiable echogenicity data of medical devices.
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A medical device includes a guidewire with a lumen, a plastic tip, and a removable mandrel. The medical device has echogenic properties which can be altered between an echogenic state and an echolucent state by evacuating the lumen and applying a liquid or gas within the lumen.
Among other things, there are disclosed embodiments of a valve implant that in particular examples are implantable within a blood vessel, which include a first set of elongate members, a second set of elongate members, and a hood affixed to the first set of elongate members. The first set of elongate members is resiliently deformable, and their distal ends are flared radially outward. The distal ends of the second set of elongate members are distal to the ends of the first set of elongate members. The hood is affixed to the first set of elongate members, and seals against the interior wall of the blood vessel in an expanded configuration. When blood flows from the proximal to the distal side of the valve implant, it presses on the hood, compressing the first set of elongate members, breaking the seal.
Medical devices include echogenic subregions and echolucent subregions arranged in an alternating pattern and having exogenous features. Examples include metal printing and cast metal being applied to a plastic structure. Other examples include a fluid contrast agent including microbubbles housed in compartments within a structure. Additional examples include small resonators built into a structure for resonating at a specific frequency and imageable with a harmonic imaging mode of an ultrasound imaging system.
Devices and methods for enhancing observability under ultrasound imaging of medical devices include temporal markers which are dynamic, producing a variable ultrasound image over time. Included are rotating markers which produce a Doppler shift visible through ultrasound imaging in a Doppler mode and which enhance visibility of the marker. Other devices and methods include alternating streams of fluid contrast agents and saline as well as destroying a fluid contrast agent stream with a high intensity ultrasound pulse.
Among other things, there are disclosed embodiments of a valve implant that in particular examples are implantable within a blood vessel, which include a first set of elongate members, a second set of elongate members, and a hood affixed to the first set of elongate members. The first set of elongate members is resiliently deformable, and their distal ends are flared radially outward. The distal ends of the second set of elongate members are distal to the ends of the first set of elongate members. The hood is affixed to the first set of elongate members, and seals against the interior wall of the blood vessel in an expanded configuration. When blood flows from the proximal to the distal side of the valve implant, it presses on the hood, compressing the first set of elongate members, breaking the seal.
A61F 2/00 - Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
Devices and methods for enhancing observability under ultrasound imaging of medical devices include temporal markers which are dynamic, producing a variable ultrasound image over time. Included are rotating markers which produce a Doppler shift visible through ultrasound imaging in a Doppler mode and which enhance visibility of the marker. Other devices and methods include alternating streams of fluid contrast agents and saline as well as destroying a fluid contrast agent stream with a high intensity ultrasound pulse.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies
76.
3D CATHETER-BASED ULTRASOUND ASSEMBLY WITH GIMBAL-MOUNT TRANSDUCER AND SINGLE-COIL DRIVE
Described are embodiments of devices and methods for imaging a body conduit, such as a blood vessel. In particular embodiments, the catheter has a chamber within which is a transducer mounted to a pivot mechanism. A coil provides a pivot force to the transducer. A magnet is attached to the transducer and is receptive of a torque applied by a magnetic field produced by energizing of the coil. A driving mechanism receives an impact from the pivot member and causes the pivot mechanism to rotate about a rotation axis.
Described are embodiments of devices and methods for imaging a body conduit, such as a blood vessel. In particular embodiments, the catheter has a chamber within which is a transducer mounted to a pivot mechanism. A coil provides a pivot force to the transducer. A magnet is attached to the transducer and is receptive of a torque applied by a magnetic field produced by energizing of the coil. A driving mechanism receives an impact from the pivot member and causes the pivot mechanism to rotate about a rotation axis.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
G01S 7/52 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group
A device for internal ultrasound procedures includes a motor which rotates a drive shaft and an ultrasound transducer. A gearing assembly provides reciprocating rotational motion from a unidirectional motor. A cam assembly provides reciprocating pivotal motion to the transducer. Conductors can attach to the transducer and extend through the drive shaft.
Disclosed are embodiments of devices and methods for imaging the inside of a body part, such as a blood vessel. In particular embodiments, a catheter has a chamber within which is a transducer mounted to a pivot mechanism, a motor for turning the transducer, and a coil for providing a pivot force to the transducer. A magnet is attached to the transducer and is receptive of a torque applied by a magnetic field produced by energizing of the coil.
Disclosed are embodiments of devices and methods for imaging the inside of a body part, such as a blood vessel. In particular embodiments, a catheter has a chamber within which is a transducer mounted to a pivot mechanism, a motor for turning the transducer, and a coil for providing a pivot force to the transducer. A magnet is attached to the transducer and is receptive of a torque applied by a magnetic field produced by energizing of the coil.
A device for internal ultrasound procedures includes a motor which rotates a drive shaft and an ultrasound transducer. A gearing assembly provides reciprocating rotational motion from a unidirectional motor. A cam assembly provides reciprocating pivotal motion to the transducer. Conductors can attach to the transducer and extend through the drive shaft.
A retrieval apparatus for removing an intravascular filter from a body vessel of a patient includes an outer sheath defining an outer lumen, an inner sheath defining an inner lumen wherein the inner sheath is positioned within the outer lumen, a retrieval member positioned in the inner lumen, an ultrasound transducer positioned on the application side of the retrieval member, a guide wire cannula extending between the outer sheath and the inner sheath, the guide wire cannula including an application side end, and a dilator located at an application side end of the retrieval apparatus, said dilator being coupled to said ultrasound transducer and receiving the application side end of said guide wire cannula.
A delivery apparatus for introducing an intravascular filter into a body vessel of a patient includes a sheath defining a lumen, an intravascular filter positioned in the lumen, an ultrasound transducer positioned to the application side of the intravascular filter, a guide wire cannula and a tip located at an application side end of the delivery apparatus.
A delivery apparatus for introducing an intravascular filter into a body vessel of a patient includes a sheath defining a lumen, an intravascular filter positioned in the lumen, an ultrasound transducer positioned to the application side of the intravascular filter, a guide wire cannula and a tip located at an application side end of the delivery apparatus.
A retrieval apparatus for removing an intravascular filter from a body vessel of a patient includes an outer sheath defining an outer lumen, an inner sheath defining an inner lumen wherein the inner sheath is positioned within the outer lumen, a retrieval member positioned in the inner lumen, an ultrasound transducer positioned on the application side of the retrieval member, a guide wire cannula extending between the outer sheath and the inner sheath, the guide wire cannula including an application side end, and a dilator located at an application side end of the retrieval apparatus, said dilator being coupled to said ultrasound transducer and receiving the application side end of said guide wire cannula.
Attachable implements, systems, and methods for identifying the migration of a medical device extending through a percutaneous insertion site of a patient's skin are disclosed. In one embodiment, an attachable implement for identifying migration comprises a attachable implement body having a coupling surface and a skin contacting surface, the coupling surface arranged to couple to a surface of the medical device, and the skin contacting surface arranged to contact the skin of the patient; wherein the attachable implement body is arranged to be side mountable on the medical device and wherein the attachable implement is configured to move from a first position adjacent to the patient's skin to a second position remote from the patient's skin. Systems, methods, and other embodiments are disclosed.
Attachable implements, systems, and methods for identifying the migration of a medical device extending through a percutaneous insertion site of a patient's skin are disclosed. In one embodiment, an attachable implement for identifying migration comprises a attachable implement body having a coupling surface and a skin contacting surface, the coupling surface arranged to couple to a surface of the medical device, and the skin contacting surface arranged to contact the skin of the patient; wherein the attachable implement body is arranged to be side mountable on the medical device and wherein the attachable implement is configured to move from a first position adjacent to the patient's skin to a second position remote from the patient's skin. Systems, methods, and other embodiments are disclosed.
A device for internal ultrasound imaging including a micro-motor rotates a drive shaft and ultrasound transducer. Conductors attach between the transducer and slip ring assemblies. The slip ring assemblies conductively couple the transducer conductors to a set of conductors extending toward a console.
A system for use with ultrasound procedures including an ultrasound control and/or imaging system which has a microminiature motor, a rotatable reflector and a stationary ultrasound transducer. The transducer may be placed between the motor and the reflector, so as to eliminate the need for placement of wires or other artifact-creating items in the path of ultrasound signals. In particular embodiments, such systems can be incorporated in or retrofitted to commercially standard diagnostic and therapeutic catheters or other housings. Examples can be used in variety of ultrasound procedures, e.g. to perform intravascular ultrasound (IVUS) imaging.
A device for endoluminal therapeutic and diagnostic ultrasound procedures includes a motor which rotates a drive shaft and ultrasound transducer. In one example, conductors attach to the transducer and extend through a hollow drive shaft. In another example, a bias member conducts electric signals and stores energy. The device includes an operational state in which the motor rotates the drive shaft alternatingly between a first direction and an opposite second direction.
A device for endoluminal therapeutic and diagnostic ultrasound procedures includes a motor which rotates a drive shaft and ultrasound transducer. In one example, conductors attach to the transducer and extend through a hollow drive shaft. In another example, a bias member conducts electric signals and stores energy. The device includes an operational state in which the motor rotates the drive shaft alternatingly between a first direction and an opposite second direction.
A device for internal ultrasound imaging including a micro-motor rotates a drive shaft and ultrasound transducer. Conductors attach between the transducer and slip ring assemblies. The slip ring assemblies conductively couple the transducer conductors to a set of conductors extending toward a console.
Among other things, there is disclosed structure and methods for registering images obtained through internal (e.g. intravascular) ultrasound devices. Embodiments of a device with a rotating ultrasound beam is provided, with a wall of the device being anisotropic in ultrasound passage. As examples, a cable opaque to ultrasound is attached along the wall of the device, so that the ultrasound beam at the location of the cable is blocked, reflected or scattered. As another example, a thin film of metallic material is placed on or in the wall to allow a portion of the beam to be blocked or attenuated. The imaging system recognizes the changes to the signals made by the anisotropic wall, and registers successive images according to those changes.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
G01S 7/52 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group
G10K 11/35 - Sound-focusing or directing, e.g. scanning using mechanical steering of transducers
G10K 11/00 - Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
94.
Devices and methods for three-dimensional internal ultrasound usage
There are disclosed embodiments of devices and methods for imaging the inside of a body part, particularly a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a linear motor, a shaft or filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
G10K 11/00 - Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
G10K 11/35 - Sound-focusing or directing, e.g. scanning using mechanical steering of transducers
A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
95.
DEVICES AND METHODS FOR THREE-DIMENSIONAL INTERNAL ULTRASOUND USAGE
There are disclosed embodiments of devices and methods for ultrasound imaging, for example of the inside of a body part such as a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a second motor operating a shaft or a filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.
Among other things, there is disclosed structure and methods for registering images obtained through internal (e.g. intravascular) ultrasound devices. Embodiments of a device with a rotating ultrasound beam is provided, with a wall of the device being anisotropic in ultrasound passage. As examples, a cable opaque to ultrasound is attached along the wall of the device, so that the ultrasound beam at the location of the cable is blocked, reflected or scattered. As another example, a thin film of metallic material is placed on or in the wall to allow a portion of the beam to be blocked or attenuated. The imaging system recognizes the changes to the signals made by the anisotropic wall, and registers successive images according to those changes.
A system for use with ultrasound procedures including an ultrasound control and/or imaging system which has a microminiature motor, a rotatable reflector and a stationary ultrasound transducer. The transducer may be placed between the motor and the reflector, so as to eliminate the need for placement of wires or other artifact-creating items in the path of ultrasound signals. In particular embodiments, such systems can be incorporated in or retrofitted to commercially standard diagnostic and therapeutic catheters or other housings. Examples can be used in variety of ultrasound procedures, e.g. to perform intravascular ultrasound (IVUS) imaging.
Described are methods and systems for testing regions of medical devices, for example lumens of cannulated delivery components or assemblies thereof, that may be used to deliver cells to a patient or otherwise contact cells or cell preparations during use. Test cells are contacted with walls of the lumens or other device regions and/or liquids that contact walls of the lumens or other device regions, potentially over an incubation period. The test cells are then assessed for an effect of the wall contact, or the liquid contact, on at least one and preferably multiple characteristics of the test cells such as innate immune response, metabolic activity, viability, cytotoxic response, colony formation and/or motility. Methods and systems as described can be used in the development and/or manufacture of cannulated delivery devices or other medical device, for example providing specifications for design or process inputs or outputs, design or process validations, and/or device lot approvals. Also described are devices or products produced in accordance with such methods and systems.
Systems and methods for treating a blood clot positioned within a blood vessel are disclosed. In one embodiment, a balloon member is positioned on a distal end region of a catheter and an ultrasound emitting element is positioned within the balloon member and arranged for actively emitting ultrasound. In some exemplary embodiments, the disclosure provides a multi-wall balloon member and a multi-lumen catheter with at least one and/or all cavities of the balloon member arranged for heat transfer with the ultrasound emitting element. The disclosure also provides catheter arrangements with an ultrasound emitting element arranged to heat tissue adjacent to the balloon member. Additionally, in some embodiments, at least one and/or all walls of the balloon member have apertures arranged to release a therapeutic agent such as a thrombolytic drug.
Systems and methods for treating a blood clot positioned within a blood vessel are disclosed. In one embodiment, a balloon member (140) is positioned on a distal end region (106) of a catheter (102) and an ultrasound emitting element (170) is positioned within the balloon member and arranged for actively emitting ultrasound. In some exemplary embodiments, the disclosure provides a multi-wall balloon member and a multi-lumen catheter with at least one and/or all cavities of the balloon member arranged for heat transfer with the ultrasound emitting element.
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