Abstract

A method for preparing a porous membrane, comprising the following steps of: a—preparing an aqueous mixture comprising a dispersion of fibres derived from an organic material in water, a solid organic binder and porous solid particles suspended in water; b—leaving the obtained aqueous mixture comprising the fibres, the organic binder and the porous solid particles under stirring for at least 10 min at room temperature; c—vacuum filtering the mixture and recovering a composite material; and d—pressing said composite material obtained in step c—to form a porous membrane.

IPC Classes  ?

• B01D 71/10 - CelluloseModified cellulose
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/14 - Dynamic membranes

Abstract

Hepatitis D virus (HDV) infection is the most severe form of chronic viral hepatitis due to rapid progression towards liver-related death and hepatocellular carcinoma. Now the inventors have demonstrated that CYP3A4 inhibitors can be useful for the treatment of HDV infections. In particular, the inventors showed that ritonavir a very potent CYP3A4 inhibitor had a significant impact on the secretion of HBs. The effects were confirmed with Saquinavir and Ketoconazole on the secretion of HBs. Finally, the inventors showed that ritonavir has a limited effect on the replication of HBV and HDV in coinfected cells, but dramatically reduced the number of infectious particles in culture supernatants. Accordingly, the present invention relates to the use of CYP3A4 inhibitors for the treatment of hepatitis D virus (HDV) infections.

IPC Classes  ?

• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/397 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
• A61K 31/4725 - Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present invention relates to a compound of formula (I) or (I'): A-X (I) A-L-B (I') wherein A and B are each independently a radical of the following formula (II) : The present invention also relates to the use of a compound of formula (I) or (I') as a colouring agent, in particular as a red colouring agent. The present invention also relates to a cosmetic, a pharmaceutical composition or a food product comprising at least one compound of formula (I) or (I').

IPC Classes  ?

• C09B 23/01 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain
• A23L 5/00 - Preparation or treatment of foods or foodstuffs, in generalFood or foodstuffs obtained therebyMaterials therefor
• C09B 23/10 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an even number of CH groups

Abstract

The present invention relates to a recombinant host cell genetically modified to produce irone compounds. It also relates to a method for producing irone compounds using said recombinant host cell.

IPC Classes  ?

• C12P 7/26 - Ketones
• C12N 9/90 - Isomerases (5.)
• C12N 15/52 - Genes encoding for enzymes or proenzymes

Goods & Services

Chemical products for use in industry and science; chemical products for use in photography; chemical products for use in agriculture; chemical products for use in horticulture; chemical products for use in forestry; unprocessed plastic materials; fertilizers; fire-extinguishing compositions; metal tempering preparations; metal soldering preparations; chemical substances for preserving foodstuffs; tanning materials; adhesives for use in industry; salt for preserving, other than for foodstuffs; chemical reagents other than for medical or veterinary use; bleaching agents for industrial use. Paints; varnishes; lacquers; anti-rust products; products against deterioration of wood; dyestuffs; mordants; metals in foil and powder form for painters, decorators, printers and artists; food colorants; printing inks; inks for leather; coatings (paints). Laundry preparations; polishing preparations; degreasing preparations; abrasive preparations; soaps; perfumes; essential oils; cosmetics; lotions for hair; dentifrices; depilatories; make-up removing products; lipstick; beauty masks; shaving products; preservatives for leather (polishes); creams for leather. Industrial oils; industrial greases; lubricants; dust absorbing, wetting and binding compositions; fuels (including motor spirits); lighting fuel; candles for lighting; lighting wicks; firewood; gas for lighting. Pharmaceutical products; veterinary products; sanitary products for medicine; disinfectant soaps; medicinal soaps; medicated shampoos; medicated dentifrices; dietetic foods for medical use; dietetic foodstuffs for veterinary use; food for babies; food supplements; medical dressings; teeth filling materials; dental impression materials; disinfectants; antibacterial products for washing hands; products for destroying vermin; fungicides; herbicides; bath preparations for medical use; sanitary panties; sanitary towels; chemical preparations for medical use; chemical preparations for pharmaceutical use; medicinal herbs; medicinal herbal teas; parasiticides; alloys of precious metals for dental use. Common metals and their alloys; building materials of metal; transportable buildings of metal; materials of metal for railway tracks; non-electric cables and wires of metal; hardware of metal; pipes of metal; ores; buildings of metal; scaffolding of metal; boxes of common metal; metal packaging containers; monuments of metal; works of art of common metal; statues of common metal; figurines of common metal; registration plates of metal. Hand-operated hand tools and implements; cutlery; table forks; spoons; side arms, other than firearms; razors; apparatus and instruments for slaughtering butchers' animals; hand-operated hand tools; shearers (hand instruments). Scientific apparatus and instruments; nautical apparatus and instruments; surveying apparatus and instruments; photographic apparatus and instruments; cinematographic cameras; optical apparatus and instruments; weighing apparatus and instruments; measuring apparatus and instruments; signaling apparatus and instruments; checking (monitoring) apparatus and instruments; teaching apparatus and instruments; sound recording apparatus; sound transmission apparatus; sound reproduction apparatus; image recording equipment; image transmission apparatus; image reproduction apparatus; digital recording media; mechanisms for coin-operated apparatus; cash registers; calculating machines; data processing equipment; computers; tablet computers; smartphones; electronic book readers; game software; software (recorded programs); computer peripherals; detectors; electric wires; electric relays; diving suits; diving gloves; diving masks; clothing for protection against accidents, irradiation and fire; protection devices for personal use against accidents; fire extinguishers; spectacles (optics); 3D spectacles; virtual reality headsets; eyewear; spectacle cases; memory cards or integrated circuit cards; bags adapted for laptops; smart watches; electric batteries; batteries for electronic cigarettes; charging stations for electric vehicles; diagnostic apparatus, not for medical use. Jewelry ("joaillerie"); jewelry; precious stones; timepieces and chronometric instruments; precious metals and alloys thereof; works of art of precious metal; jewelry cases; boxes of precious metal; watch cases; watch bands; watch chains; watch springs; watch glasses; key rings (split rings with trinket or decorative fob); statues of precious metal; figurines (statuettes) of precious metal; cases for timepieces; presentation cases for timepieces; medals. Musical instruments; electronic musical instruments; music stands; cases for musical instruments. Printing products (printed matter); bookbinding material; photographs; stationery; adhesives for stationery or household purposes; artists' materials; paintbrushes; office requisites (except furniture); instructional or teaching material (except apparatus); printing type; paper; cardboard; boxes of paper or cardboard; posters; albums; cards; books; newspapers; prospectuses; pamphlets; calendars; writing instruments; engravings (works of art); lithographic works of art; paintings (pictures), framed or unframed; sewing patterns; drawings; drawing instruments; handkerchiefs of paper; face towels of paper; table linen of paper; toilet paper; bags (envelopes, pouches) of paper or plastic materials for packaging; garbage bags of paper or of plastics. Leather; animal skins and hides; trunks and suitcases; umbrellas and parasols; walking sticks; whips; saddlery; wallets; purses (coin purses); credit card cases [wallets]; bags; vanity cases; collars for animals; clothing for pets. Furniture; mirrors (looking glasses); picture frames; works of art made of wood, wax, plaster or plastic materials; clothes hangers; chests of drawers; cushions; shelves; packaging containers of plastic materials; armchairs; seats; bedding except linen; mattresses; plate racks; boxes of wood or plastic materials. Utensils for household use; kitchen utensils; containers for household use; kitchen containers; combs; sponges; brushes (except paintbrushes); brush-making materials; hand-operated cleaning instruments; steel wool; unworked or semi-worked glass, except building glass; porcelain ware; earthenware; bottles; art objects of porcelain, ceramic, earthenware or glass; statuettes of porcelain, ceramic, earthenware or glass; figurines (statuettes) of porcelain, ceramic, earthenware or glass; utensils [accessories] for hygiene and beauty care; toilet cases; trash cans; glasses (receptacles); tableware. Ropes; strings; tents; tarpaulins; sails (rigging); padding and stuffing materials (except of rubber or plastics); raw fibrous textile materials; cables not of metal; packing (stuffing) materials other than of rubber or of plastic materials; textile fibers; large-capacity bags for the transport and storage of materials in bulk; bags (covers, pouches) of textile for packaging. Fabrics; bed blankets; fabrics for textile use; elastic fabrics; velvet; bed linen; household linen; table linen not of paper; bath linen with the exception of clothing; sleeping bags. Clothing; shoes; headwear; shirts; leather clothing; belts (clothing); furs (clothing); gloves (clothing); scarves; neckties; hosiery; socks; slippers ("chaussons"); beach shoes; ski boots; sports shoes; underwear. Lace; embroidery; ribbons; buttons; hooks (haberdashery); pins; needles; artificial plants; artificial flowers; haberdashery, except yarns; lace trimmings; wigs; fasteners for clothing; fastenings for clothing; decorative articles for the hair. Carpets; doormats; mats; linoleum; coverings for floors; wall hangings not of textile; rugs; wallpapers; gymnastic mats; carpets for automobiles; artificial turf. Games; toys; toys for pets; baby gyms; controllers for game consoles; ornaments for Christmas trees, except illumination articles and confectionery; apparatus for physical education; appliances for gymnastics; fishing tackle; balls for games; billiard tables; billiard cues; billiard balls; playing cards; table-top games; ice skates; roller skates; scooters [toys]; sailboards; surfboards; rackets; snowshoes; skis; protective padding (parts of sportswear); toy models; figurines [toys]; toy robots. Meat; fish; poultry; game; preserved fruit; frozen fruits; dry fruits; cooked fruits; preserved vegetables; deep-frozen vegetables; dried vegetables; cooked vegetables; jellies; jams; compotes; eggs; milk; dairy products; oils for food; butter; charcuterie; salted meats; crustaceans (not live); shellfish, not live; edible insects, not live; canned meat; canned fish; cheeses; milk beverages with milk predominating. Coffee; tea; cocoa; sugar; rice; tapioca; flour; cereal preparations; bread; pastries; confectionery; edible ices; honey; agave syrup (natural sweetener); yeast; salt; mustard; vinegar; sauces (condiments); spices; ice for refreshment; sandwiches; pizzas; pancakes; cookies (biscuits); cakes; rusks; sugar confectionery; chocolate; cocoa-based beverages; coffee-based beverages; tea-based beverages. Agricultural, aquacultural, horticultural and forestry products; live animals; fresh fruits; fresh vegetables; seeds (grains); natural plants; natural flowers; animal foodstuffs; malt; natural turf; live crustaceans; live shellfish; live edible insects; live bait for fishing; unprocessed cereal grains; plants; seedlings; trees (plants); unsawn timber; fodder. Beers; mineral waters (beverages); carbonated waters; fruit-based beverages; fruit juices; syrups for beverages; preparations for making beverages; lemonades; fruit nectars; soda water; non-alcoholic aperitifs. Education; training; entertainment; sporting and cultural activities; information with respect to entertainment; information with respect to education; vocational retraining; providing recreational facilities; publication of books; book lending; providing non-downloadable films via video-on-demand services; motion picture production; rental of television sets; rental of show scenery; photography services; organization of competitions (education or entertainment); organization and conducting of colloquiums; organization and conducting of conferences; organization and conducting of congresses; organization of exhibitions for cultural or educational purposes; booking of seats for shows; game services provided online from a computer network; gambling services; electronic publication of books and journals online. Technical evaluations concerning design (engineers' services); scientific research; technical research; design of computers for third parties; computer development; software design; software development; research and development of new products for third parties; conducting of technical project studies; architecture; design of interior decor; software development (design); software installation; software maintenance; updating of software; software rental; programming for computers; computer system analysis; computer system design; consultant services with respect to computer hardware design and development; digitization of documents; Software as a Service (SaaS); cloud computing; advice regarding information technology; server hosting; motor vehicle roadworthiness testing; graphic arts design services; styling (industrial design); authentication of works of art; energy auditing; electronic data storage. Agricultural, horticultural and forestry services; medical services; veterinary services; skin care services (beauty and sanitary care); medical assistance; plastic surgery; hospital services; nursing homes; rehabilitation clinic services; rest home services; opticians' services; alternative medicine services; beauty salon services; hairdressing salon services; pet grooming; gardening; landscape gardening services.

Abstract

The invention relates to an automated system (100) for processing physiological parameter measurements for providing a medical risk assessment, characterized in that it comprises: - a module (104) for receiving physiological parameter measurements (p1…p15) for a female to be assessed; and - a module (106) for calculating a nonclassical 21-hydroxylase deficiency score (SNC21OHD) for the female to be assessed, according to a model which gives the score (SNC21OHD) on the basis of the measurements (p1…p15) received. The physiological parameters comprise at least the following steroids: 21-deoxycortisol; 21-deoxycorticosterone; 11β-hydroxyandrostenedione; 17-OH-progesterone; androstenedione; corticosterone; and testosterone.

IPC Classes  ?

• G01N 33/74 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving hormones

Abstract

The invention relates to a method for preparing a porous membrane, the method comprising the following steps: a- preparing an aqueous mixture comprising a dispersion of fibres from a water-based organic material, a solid organic binder and porous solid particles suspended in water; b- stirring the aqueous mixture comprising the fibres, the organic binder and the porous solid particles for at least 10 minutes at room temperature; c- vacuum filtering the mixture and recovering a composite material; and d- pressing the composite material obtained in step c- to form a porous membrane.

IPC Classes  ?

• B01D 71/10 - CelluloseModified cellulose
• B01D 69/14 - Dynamic membranes
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• D21H 21/28 - Colorants
• D21H 17/68 - Water-insoluble compounds, e.g. fillers or pigments siliceous, e.g. clays
• D21H 17/63 - Inorganic compounds
• D21H 11/18 - Highly hydrated, swollen or fibrillatable fibres

Abstract

The present invention relates to a method of determining metabolic parameters of one or several muscular motor units by coupling muscular response to ventilatory response of a subject, comprising, from a step of performing efforts (i) using a test device by the subject moving on the test device; (ii)-a step of instantaneously measuring the movement speed of one or several muscular motor units of the subject v(t), and the oxygen flow rate φO2t); (iii)-a step of plotting the COT curve of the oxygen flow rate of the subject against the movement speed of one or several muscular motor units of the subject v(t), (iv)-a step of determining the following metabolic parameters from the COT curve: Basal power B which is the vertical asymptote at the origin, Flow resistance RM which is the oblique asymptote at high intensities.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition

Abstract

The present invention relates to novel quorum sensing inhibitors and compositions containing said inhibitors. These inhibitors disturb the establishment of bacterial biofilms, "swarming" and the production of secondary metabolites of bacteria, in particular pathogenic bacteria, by a mechanism for inhibiting bacterial communication, referred to as quorum sensing.

IPC Classes  ?

• C07D 307/68 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• C07D 307/84 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• A01N 43/08 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom five-membered rings with oxygen as the ring hetero atom

Goods & Services

Chemicals for use in industry and science; Chemical preparations for use in photography; Chemicals for use in agriculture; Chemicals used in horticulture; Chemicals used in forestry; Unprocessed plastics; Fertilizers; Fire extinguishing compositions; Chemical substances for preserving foodstuffs; Tanning substances; Adhesives for use in industry; Salt for preserving, other than for foodstuffs; Chemical reagents, other than for medical or veterinary purposes; Decolorants for industrial purposes. Paints and washes; Varnishes; Lacquers; Anti-rust preparations; Wood preservatives; Colorants; Mordants; Metal foil for painters, decorators, printers and artists; Food dyes; Printing ink; Ink for skin-dressing; Coatings. Laundry preparations; Polishing preparations; Grease-removing preparations; Abrasives; Soap; Perfumes; Ethereal oils; Cosmetics; Hair lotions; Dentifrices; Depilatory preparations; Make-up removing preparations; Lip rouge; Beauty masks; Shaving preparations; Leather preservatives [polishes]; Creams for leather. Industrial oil; Industrial grease; Lubricants; Dust controlling compositions; Fuels (including motor spirit); Lighting fuel; Candles for lighting; Perfumed candles; Wicks; Firewood; Gas for lighting. Pharmaceuticals; Veterinary preparations; Sanitary preparations for medical purposes; Disinfectant soap; Medicated soap; Medicated shampoos; Medicated dentifrices; Dietetic foods adapted for medical purposes; Dietetic food adapted for veterinary use; Food for babies; Food supplements; Dressings, medical; Teeth filling material; Dental impression materials; Disinfectants; Antibacterial handwashes; Preparations for destroying noxious animals; Fungicides; Weedicides; Bath preparations for medical purposes; Sanitary panties; Sanitary towels; Chemical preparations for medical purposes; Chemical preparations for pharmaceutical purposes; Medicinal herbs; Herbal teas for medicinal purposes; Parasiticides. Boxes of common metal; Cans of metal; Monuments of metal; Works of art of common metal; Statues of common metal; Figurines of common metal. Cutlery; Table forks; Spoons; Hand tools, hand-operated; Shearers [hand instruments]. Scientific apparatus and instruments; Nautical apparatus and instruments; Surveying apparatus and instruments; Photographic apparatus and instruments; Cinematographic cameras; Optical apparatus and instruments; Weighing apparatus and instruments; Measuring apparatus and instruments; Signalling apparatus and instruments; Checking (supervision) apparatus and instruments; Teaching apparatus and instruments; Sound recording apparatus; Sound transmitting apparatus; Sound reproduction apparatus; Apparatus for recording images; Apparatus for the transmission of images; Apparatus for the reproduction of images; Digital recording media; Data processing equipment; Computers; Tablet computers; Smartphones; Electronic book readers; Games software; Computer software, recorded; Computer peripheral devices; Spectacles; 3D spectacles; Virtual reality headsets; Eyewear; Covers for glasses; Bags adapted for laptops; Smartwatches; Electronic publications, downloadable; Electronic data files (downloadable); Computer software applications, downloadable; Downloadable mobile applications for use with wearable computer devices; Teaching robots. Jewellery; Ornaments [jewellery, jewelry (Am.)]; Precious stones; Chronometric apparatus and instruments; Precious metals and their alloys; Works of art of precious metal; Jewel cases; Boxes of precious metal; Watch cases [parts of watches]; Watch bands; Watch chains; Watch springs; Watch glasses; Key rings [split rings with trinket or decorative fob]; Statues of precious metal; Figurines of precious metal; Cases for clock- and watchmaking; Cases for watches [presentation]; Medals. Musical instruments; Electronic musical instruments; Music stands; Cases for musical instruments. Printed matter; Publications of paper; Bookbinding material; Photographs [printed]; Stationery; Adhesives for stationery or household purposes; Artists' materials; Paintbrushes; Office requisites, except furniture; Teaching materials [except apparatus]; Printing type; Paper; Cardboard; Boxes of paper or cardboard; Posters; Albums; Cards; Books; Newspapers; Prospectuses; Pamphlets; Calendars; Writing instruments; Engravings; Lithographic works of art; Paintings [pictures], framed or unframed; Graphic prints; Drawing instruments; Handkerchiefs of paper; Face towels of paper; Table linen of paper; Bags [envelopes, pouches] of paper or plastics, for packaging; Composing sticks. Skins (animal-); Animal skins; Trunks and suitcases; Umbrellas and parasols; Walking sticks; Whips; Saddlery; Pocket wallets; Purses; Credit card cases [wallets]; Bags; Collars for animals; Clothing for pets; Bags [envelopes, pouches] of leather, for packaging; Bags [envelopes, pouches] of leather, for packaging; Vanity cases, not fitted. Furniture; Mirrors (silvered glass); Picture frames; Works of art of wood, wax, plaster or plastic; Cushions; Racks [furniture]; Packaging containers of plastic; Armchairs; Seats; Bedding, except linen; Kitchen dressers [furniture]; Boxes of wood or plastic. Kitchen utensils; Kitchen containers; Combs; Sponges; Brushes; Material for brush-making; Cleaning instruments, hand-operated; Glass, unworked or semi-worked, except building glass; Porcelain ware; Earthenware; Bottles; Works of art of porcelain, ceramic, earthenware or glass; Statues of porcelain, ceramic, earthenware or glass; Figurines [statuettes] of porcelain, ceramic, earthenware or glass; Toilet utensils; Fitted vanity cases; Glasses [receptacles]; Tableware, other than knives, forks and spoons. Ropes; String; Tents; Tarpaulins; Sails; Padding materials, not of rubber, plastics, paper or cardboard; Raw fibrous textile; Cables, not of metal; Packing [cushioning, stuffing] materials, not of rubber, plastics, paper or cardboard; Textile fibres; Sacks for the transport and storage of materials in bulk; Bags [envelopes, pouches] of textile, for packaging. Textiles; Bed blankets; Fabrics for textile use; Elastic woven fabrics; Velvet; Bed linen; Linens; Table linen, not of paper; Bath linen, except clothing; Sleeping bags. Clothing; Shoes; Headgear; Shirts; Leather dresses; Belts [clothing]; Furs [clothing]; Gloves [clothing]; Scarves; Neckties; Hosiery; Socks; Slippers; Beach shoes; Ski boots; Sports shoes; Underwear. Lace trimmings; Embroidery; Ribbons; Buttons; Hooks [haberdashery]; Pins; Needles; Artificial plants, other than Christmas trees; Artificial flowers; Haberdashery [dressmakers' articles], except thread; Lace trimmings; Wigs; Fastenings for clothing; Fastenings for clothing; Decorative articles for the hair. Carpets; Door mats; Mats; Floor coverings; Wall hangings, not of textile; Carpets; Wallpaper; Gymnastic mats; Carpets for automobiles. Games; Toys; Toys for pets; Baby gyms; Controllers for game consoles; Festive decorations and artificial Christmas trees; Appliances for gymnastics; Appliances for gymnastics; Fishing tackle; Playground balls; Billiard tables; Snooker cues; Billiard balls; Playing cards; Table-top games; Ice skates; Roller skates; Scooters [toys]; Sailboards; Sailboards; Rackets; Snowshoes; Skis; Protective paddings [parts of sports suits]; Toy models; Toy figures; Toy robots. Jams; Compotes; Jellies for food. Coffee; Tea; Cocoa; Sugar; Rice; Tapioca; Flour; Cereal preparations; Bread; Pastries; Confectionery; Edible ices; Honey; Agave syrup [natural sweetener]; Yeast; Salt; Mustard; Vinegar; Sauces [condiments]; Spices; Ice for refreshment; Sandwiches; Pizzas; Pancakes; Biscuits; Cakes; Rusks; Confectionery; Chocolate; Cocoa-based beverages; Coffee-based beverages; Tea-based beverages. Agricultural and aquacultural crops, horticulture and forestry products; Live animals; Fruit, fresh; Vegetables, fresh; Seeds for planting; Natural plants; Flowers; Animal foodstuffs; Malt; Natural turf; Crustaceans, live; Shellfish, live; Edible insects, live; Fishing bait, live; Cereal seeds, unprocessed; Plants; Seedlings; Trees; Unsawn timber. Beer; Mineral water [beverages]; Aerated water; Fruit-based beverages; Juices; Syrups for beverages; Preparations for making beverages; Lemonades; Fruit nectars, non-alcoholic; Soda water; Aperitifs, non-alcoholic. Teaching; Training; college education; Entertainment services; Educational activities, Conducting of cultural activities, and Entertainment Including shows; Providing museum facilities; Presenting museum exhibitions; Information in relation to the following fields: Teaching, Training, college education, Entertainment services, Educational activities, Conducting of cultural activities, and Entertainment Including shows; Publication of books and journals, Publication of works; Lending library services, Lending of specialist works and journals; Providing of audiovisual works, reporting, animated films, films, non-downloadable images, via video-on-demand services; Production of audiovisual works, Production of reporting (audiovisual works), Creating animated cartoons, Production of cinematographic films, Radio broadcasting, Production of internet radio programmes, Production of podcasts, Television show production, Production of shows; Lending library services; Multimedia library services; Providing online virtual guided tours; Arranging and conducting of colloquiums, Arranging and conducting of conferences, Arranging and conducting of congresses, Arranging and conducting of workshops [training], Arranging and conducting of educational workshops, Arranging and conducting of in-person educational forums; Organisation of competitions for cultural purposes or Arranging of competitions (education) or Arranging of competitions for educational purposes; Arranging exhibitions for cultural or educational or entertainment purposes or Organization of exhibitions For educational purposes; Booking of museum tickets; Shows; Gaming for educational purposes provided online via a computer network; Electronic publication of books on-line, Electronic publication of works online, Electronic publishing of online specialist journals; Transfer of business knowledge and know-how [training]; Know-how transfer [training]. Scientific research, Especially in relation to the following fields: The living world, the mineral world and the interaction thereof with humans; Technical research; Computer software design; Software development; Research and development of new products for others; Conducting technical project studies; Architecture; Design of interior decor; Computer software design; Installation of computer software; Maintenance of computer software; Updating of computer software; Rental of computer software; Computer programming; Computer system analysis; Computer system design; Digitization of documents; Software as a service [SaaS]; Cloud computing; Information technology [IT] consultancy; Server hosting; Authenticating works of art; Electronic data storage. Agriculture, horticulture and forestry services; Animal healthcare services; Gardening; Landscape gardening.

Abstract

The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH) enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.

IPC Classes  ?

• A61K 38/50 - Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• C12N 9/80 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/46 - Hydrolases (3)
• A61K 35/741 - Probiotics
• A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• G01D 5/24 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying capacitance
• H03K 17/955 - Proximity switches using a capacitive detector

Abstract

The present invention relates to a composite material that can be used as an optical indicator, combining (A) at least one porous crystalline MOF, preferably in the form of nanoparticles, and (b) anisotropically-shaped nanoparticles of at least one metal or metal alloy having a plasmon band in the visible range, the metal being chosen from Au, Ag, Cu and Pd or a homogeneous or non-homogeneous mixture or an alloy thereof. The invention also relates to a method for preparing the composite material, a device for optically detecting the saturation of an MOF adsorbent with volatile organic compounds, and the use of the composite material as an optical indicator of the saturation of an MOF adsorbent with volatile organic compounds.

IPC Classes  ?

• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
• B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
• B01J 20/32 - Impregnating or coating
• G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation

Abstract

The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH)enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.

IPC Classes  ?

• A61K 38/50 - Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
• C12N 9/80 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/46 - Hydrolases (3)
• A61K 35/741 - Probiotics
• A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• G01D 5/24 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying capacitance
• H03K 17/955 - Proximity switches using a capacitive detector

Abstract

The present disclosure relates to 2,6-diaminopurine (DAP) for use in the treatment of a disease caused by a nonsense mutation in a gene, leading to the premature insertion of a UGA stop codon.

IPC Classes  ?

• A61K 31/52 - Purines, e.g. adenine
• A61K 31/7064 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61K 31/4245 - Oxadiazoles
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to nuclease protein fusions for enhancing genome editing by homology-directed transgene integration (HDI). The inventors found that the rate of HDI mediated by the CRISPR/Cas9 system may be substantially improved by providing the Cas9 nuclease in the form of a fusion protein with at least the N-terminal domain of the CtIP protein. CtIP proteins are involved in the early steps of homologous recombination. In addition, the inventors identified the subdomains of the N-terminal domain of the CtIP protein that are important for improving the HDI rate. Thus, the invention relates to fusion proteins comprising a Cas9 protein, a tetramerization domain of a CtIP protein and a dimerization domain of a CtIP protein. Particularly, the inventors have tested these fusion proteins HEK293 cells, RG37DR cells and Sprague-Dawley rats.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 9/22 - Ribonucleases
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

The present invention relates to 2,6-diaminopurine (DAP) for use in the treatment of a disease caused by a nonsense mutation in a gene, leading to the premature insertion of a UGA stop codon.

IPC Classes  ?

• A61K 31/52 - Purines, e.g. adenine
• A61K 31/7064 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to 2,6-diaminopurine (DAP) for use in the treatment of a disease caused by a nonsense mutation in a gene, leading to the premature insertion of a UGA stop codon.

IPC Classes  ?

• A61K 31/52 - Purines, e.g. adenine
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61K 31/7064 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
• A61P 35/00 - Antineoplastic agents

Abstract

The invention concerns the use of Lepista flaccida intended for treating a disease caused by a nonsense mutation of a gene resulting in the premature introduction of a UGA and/or UAA stop codon. It also concerns a Lepista flaccida extract comprising at least 2,6-diaminopurine (DAP) obtained by maceration or infusion of Lepista flaccida in a solvent. It also concerns this Lepista flaccida extract intended to be used for treating a disease caused by a nonsense mutation of a gene resulting in the premature introduction of a UGA and/or UAA stop codon. It additionally concerns a therapeutic treatment method comprising a step of administering Lepista flaccida or a Lepista flaccida extract or a pharmaceutical composition comprising this Lepista flaccida extract. The invention is applicable in the pharmaceutical field, in particular for treating diseases caused by a nonsense mutation of a gene resulting in the premature introduction of a UGA and/or UAA stop codon.

IPC Classes  ?

• A61K 31/7064 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
• A61K 36/06 - Fungi, e.g. yeasts
• A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The present invention relates to the use of a pyrenocine compound or a pyrenochaetic acid compound for the prevention or the treatment in algae of diseases induced by protistan pathogens. The present invention also relates to a new pyrenocine compound.

IPC Classes  ?

• C07D 309/38 - Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
• A01P 3/00 - Fungicides
• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom
• A01N 63/04 - Microbial fungi;  Substances produced thereby or obtained therefrom

Goods & Services

Chemical products for use in industry, science, photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; soil fertilizers; fire-extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning materials; adhesives for use in industry; preserving salt, other than for foodstuffs; chemical reagents other than for medical or veterinary use; bleaching agents for industrial use. Industrial oils and greases; lubricants; dust-absorbing, wetting and binding compositions; fuels (including motor spirit) and illuminants; candles, wicks for lighting; firewood; gas for lighting. Pharmaceutical and veterinary products; sanitary products for medical purposes; dietetic food and substances for medical or veterinary use; food for babies; food supplements for humans and animals; materials for dressings; material for dental fillings and dental impressions; disinfectants; products for destroying vermin; fungicides, herbicides; bath preparations for medical use; sanitary panties or napkins; chemical preparations for medical or pharmaceutical use; medicinal herbs; herbal teas; parasiticides; alloys of precious metals for dental use. Machine tools; motors and engines (other than for land vehicles); machine couplings and transmission components (other than for land vehicles); agricultural implements other than hand-operated; automatic distribution machines; agricultural machines; suction machines for industrial use; woodworking machines; automatic handling machines (manipulators); packaging or packing machines; pumps (machines); electric hand drills; clippers (machines); bulldozers; grinding machines; centrifugal machines; elevators; machines for sewing, for knitting; ironing machines; laundry washing machines; electric kitchen machines; sorting machines for industry; saws (machines); robots (machines); printing machines; drilling machines; elevators (lifts); electric knives. Hand-operated hand tools and implements; cutlery, forks and spoons; side arms, other than firearms; razors; apparatus for slaughtering butchers' animals; hand-operated hand tools; clippers (hand implements). Scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signaling, checking (supervision), life-saving and teaching apparatus and instruments; apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; apparatus for recording, transmission or reproduction of sound or images; magnetic recording media, optical or sound recording disks; compact disks, DVDs and other digital recording media; mechanisms for coin-operated apparatus; cash registers; calculating machines; data processing equipment, computers; electronic tablets, smartphones, e-book readers; game software; software (recorded programs); computer peripherals; electric batteries; detectors; electric wires; electric relays; diving suits, gloves or masks; clothing for protection against accidents, irradiation and fire; protection devices for personal use against accidents; fire extinguishers; spectacles (optics); 3D spectacles; optical goods; spectacle cases; diagnostic apparatus not for medical use; integrated circuit cards [smart cards]; bags designed for laptop computers. Apparatus for lighting, heating, steam generating, cooking, refrigerating, drying, ventilating, water supply and sanitary purposes; air-conditioning apparatus or installations; freezers; flashlights; electric coffee machines; cookers (cooking stoves); lighting apparatus for vehicles; heating or air-conditioning installations for vehicles; air or water purifying apparatus and machines; sterilizers. Vehicles; apparatus for locomotion by land, air or water; motors and engines for land vehicles; suspension shock absorbers for vehicles; bodies for vehicles; anti-skid chains; vehicle chassis or bumpers; sun-blinds adapted for automobiles; safety belts for vehicle seats; electric vehicles; caravans; tractors; mopeds; cycles; frames, kickstands, brakes, handlebars, wheel rims, pedals, tires, wheels or saddles for cycles and bicycles; strollers; handling carts. Printing products (printed matter); bookbinding material; photographs; stationery; adhesives for stationery or household purposes; artists' materials; paintbrushes; typewriters and office requisites (except furniture); instructional or teaching material (except apparatus); printing type; printing blocks; paper; cardboard; boxes of cardboard or paper; posters; albums; cards; books; newspapers; prospectuses; pamphlets; calendars; writing instruments; engravings or lithographic works of art; paintings (pictures), framed or unframed; aquarelles; patterns for dressmaking; graphic prints; drawing instruments; handkerchiefs of paper; face towels of paper; table linen of paper; toilet paper; bags and small bags (envelopes, pouches) of paper or plastic for packaging; garbage bags of paper or of plastics. Rubber, gutta-percha, gum, asbestos, mica; plastics in extruded form for use in manufacture; packing, stopping and insulating materials; flexible pipes not of metal; rubber stoppers; packing (cushioning, stuffing) materials of rubber or plastics; plastic sheeting for agricultural use; foils of metal for insulating; insulating gloves, strips, fabrics or varnishes; artificial or synthetic resins (semi-finished goods); bags or small bags (envelopes, pouches) of rubber for packaging; glass wool or fibers for insulation. Building materials, not of metal; non-metallic rigid pipes for building; asphalt, pitch and bitumen; transportable buildings not of metal; monuments not of metal; buildings, not of metal; scaffolding, not of metal; building glass; insulating glass (building); concrete; cement; works of art made of stone, concrete or marble; statues or figurines (statuettes) of stone, concrete or marble; stained-glass windows; building lumber; manufactured timber. Furniture, mirrors, picture frames; works of art made of wood, wax, plaster, cork, reed, cane, wicker, horn, bone, ivory, whalebone, shell, amber, mother-of-pearl, meerschaum, substitutes for all these materials or of plastic; coat hangers; chests of drawers; cushions; racks; packaging containers of plastic; armchairs; seats; bedding (excluding bed linen); mattresses; plate racks; boxes of wood or plastic. Utensils and containers for household or kitchen use; combs and sponges; brushes (except paintbrushes); brush-making materials; hand-operated cleaning instruments; steel wool; unworked or semi-worked glass (except building glass); porcelain ware; earthenware; bottles; art objects of porcelain, ceramic, earthenware or glass; statues or figurines (statuettes) of porcelain, ceramic, earthenware or glass; toilet utensils or cases; trash cans; glasses (receptacles); tableware. Fabrics; bed blankets; fabrics for textile use; elastic fabrics; velvet; bed linen; household linen; table linen not of paper; bath linen (except clothing). Carpets, rugs, mats and matting, linoleum and other materials for covering existing floors; wall hangings not of textile; rugs; wallpapers; gymnastic mats; carpets for automobiles; artificial turf. Games, toys; controls for game consoles; decorations for Christmas trees; Christmas trees of synthetic materials; apparatus for physical education or gymnastics; fishing tackle; balls for games; billiard tables, cues or balls; playing cards or board games; ice or roller skates; scooters (toys); sailboards or surf boards; rackets; snowshoes; skis; protective padding (parts of sportswear); toy models; figurines (toys). Meat, fish, poultry and game; meat extracts; preserved, frozen, dried and cooked fruits and vegetables; jellies, jams, compotes; eggs, milk and dairy products; edible oils and fats; fats for food; butter; charcuterie; salted meats; crustaceans (not live); canned meat or fish; cheeses; milk beverages, milk predominating. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery products, edible ices; honey, treacle; yeast, baking powder; salt, mustard; vinegar, sauces (condiments); spices; ice for refreshment; sandwiches, pizzas; pancakes; biscuits, cookies; cakes; rusks; sugar confectionery; chocolate; beverages based on cocoa, coffee, chocolate or tea. Agricultural, horticultural and forestry products, neither prepared, nor processed; live animals; fresh fruits and vegetables; plant seeds (grains), natural plants and flowers; animal foodstuffs; malt; natural turf; live crustaceans; live bait for fishing; unprocessed cereal grains; shrubs; plants; seedlings; trees (plants); fresh citrus fruits; unsawn timber; fodder. Beers; mineral and aerated waters; beverages based on fruit and fruit juices; syrups and other preparations for making beverages; lemonades; fruit nectars; soda water; non-alcoholic aperitifs. Alcoholic beverages (except beers); ciders; digesters (liqueurs and spirits); wines; spirits; wines protected by an appellation of origin; wines protected by a geographical indication. Sawing; dressmaking; printing; information relating to the treatment of materials; embroidery services; soldering; burnishing by abrasion; planing; refining services; grinding; flour milling; engraving services; galvanization; gilding services; tin plating; dyeing services; clothing alteration; textile treating; bookbinding services; framing of works of art; air purification; vulcanization (treatment of materials); decontamination of hazardous materials; production of energy; photographic printing; photographic film development; silkscreen printing; photoengraving services; glass blowing; taxidermy; waste treatment (transformation); sorting of waste and recyclable raw material (transformation); recycling of trash and waste. Education; training; entertainment; sporting and cultural activities; information relating to entertainment or education; vocational retraining; provision of recreational facilities; publication of books; book lending; production and rental of motion pictures; rental of sound recordings; rental of television sets; rental of show scenery; videotape editing; photography services; organization of competitions (education or entertainment); organization and conducting of colloquiums, conferences or congresses; organization of exhibitions for cultural or educational purposes; booking of seats for shows; game services provided on-line from a computer network; gambling services; electronic publication of books and periodicals online; desktop publishing. Evaluations and assessments in the fields of science and technology provided by engineers; scientific and technical research; design and development of computers and software; research and development of new products for others; technical project studies; architecture; design of interior decor; development (design), installation, maintenance, updating or rental of software; computer programming; computer system analysis; computer system design; consultancy in the design and development of computers; digitization of documents; SaaS (software as a service); cloud computing; information technology (IT) consultancy; hosting of servers; vehicle roadworthiness testing; graphic arts design services; styling (industrial design); authentication of works of art; energy auditing; electronic data storage. Services for providing food and drink; temporary accommodation; bar services; food and drink catering; hotel services; temporary accommodation reservation; day-nurseries [crèches]; providing campground facilities; retirement homes; boarding for animals. Agricultural, horticultural and forestry services; medical services; veterinary services; hygienic and beauty care for human beings or animals; medical assistance; cosmetic surgery; hospital services; nursing homes; convalescence or rest homes; opticians' services; alternative medicine services; beauty salons; hairdressing salons; pet grooming; gardening; landscape gardening services.

Abstract

The present invention relates to a force sensor (1), comprising: - at least one measurement cell (2), each measurement cell being filled with a filling material (3) in which is embedded at least one inclusion of matter (4), - for each cell, at least one light source (5) arranged so as to illuminate the inclusion embedded in this cell, - for each cell, a measurement system comprising at least one optical measurement point (7) arranged so as to sense the light originating from the inclusion embedded in this cell, for each cell, means (9, 10) arranged so as to transform optical signals (16) originating from the measurement system of this cell into a signal representative of a force (11) exerted on this cell, this signal depending on a displacement of the inclusion embedded within the filling material of this cell.

IPC Classes  ?

• G01L 5/16 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for measuring several components of force
• G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis

Abstract

The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile- salt hydrolase (BSH)enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis,and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• A23L 1/30 - containing additives (A23L 1/308 takes precedence);;
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/46 - Hydrolases (3)
• A61K 35/74 - Bacteria
• A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
• C07K 14/335 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Lactobacillus (G)
• C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
• A61K 35/741 - Probiotics
• A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs

Abstract

The invention relates to an easy-to-handle gardening machine that is suitable for weeding small spaces. The gardening machine comprises a chassis (1) provided with: a means (2) for securing a gardening implement (3); a first movement member (4) for moving along the ground (S), arranged at the front of the chassis relative to the implement-securing means with reference to the use position; and at least one gripping handle (5). The machine is characterised in that it comprises: a second movement member (6) for moving along the ground, arranged behind the first movement member (4); at least one means (7) for positioning the implement-securing means relative to the ground, arranged on the chassis such that when the two movement members are kept in contact with the ground during use, a force (F) exerted on at least one part of the chassis moves the implement-securing means in translation (T) towards the ground relative to the movement members.

IPC Classes  ?

• A01B 33/02 - Tilling implements with rotary driven tools with tools on horizontal shaft transverse to direction of travel
• B62D 51/04 - Motor vehicles characterised by the driver not being seated the driver walking

Abstract

The invention relates to a method of generating control commands for coordinating displacement members of a moving platform, so as to make said moving platform progress between an initial speed and a final speed according to at least two locomotive situations. The method of the invention is characterized in that each locomotive situation is associated with an elementary module (Mk) corresponding thereto for generating commands for controlling coordination between a predetermined module start speed and a predetermined module end speed, and in that domains of application of these elementary modules are represented in the form of a predetermined chart for stringing together adjoining modules covering at least partially, by juxtaposition of their start and end speeds, the spectrum of possible initial and final speeds of displacement of the platform, so as to allow the determination (330) of a series of elementary modules to be strung together to pass from the initial speed (Vi) to the final speed (Vf) and the concatenation (340) of the modules of this series so as to derive therefrom a series of corresponding control commands (350) for the displacement members for the moving platform.

IPC Classes  ?

• B25J 9/16 - Programme controls
• B62D 57/032 - Vehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted supporting base and legVehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted feet or skid

Abstract

The invention proposes a composter for an apartment, which avoids the presence of flies in the apartment, which avoids the problem of clutter and which can be adapted to most city apartments which have railings on windows or on balconies. For this purpose, the subject matter of the invention is an organic waste composter comprising a reservoir tank and at least one composting tank which can be positioned above the reservoir tank. The reservoir tank comprises a rigid bottom which has, on an external face of said bottom, a groove which is substantially vertical relative to the position of use, capable of accepting a part of a railing so as to fit the composter over the railing.

IPC Classes  ?

• C05F 17/00 - Preparation of fertilisers characterised by biological or biochemical treatment steps, e.g. composting or fermentation
• C05F 17/02 - Apparatus therefor

Abstract

2, or a combination thereof.

IPC Classes  ?

• C12Q 1/44 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase

Abstract

The present invention relates to a compound having the following formula (I), wherein : - R1 and R2 are alkyl groups having from 1 to 12 carbon atoms; - X1 is NH or O;- R3, R4, R5 and R6 are in particular H; - X2 is in particular -CH2-; - n is an integer comprised from 2 to 20; and - R is an inhibitor of DNA methyltransferases, or its pharmaceutically acceptable salts, hydrates or hydrated salts or its polymorphic crystalline structures, racemates, diastereomers or enantiomers.

IPC Classes  ?

• C07D 209/48 - Iso-indolesHydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
• C07D 311/30 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
• C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/4035 - Isoindoles, e.g. phthalimide
• A61P 35/00 - Antineoplastic agents
• A61P 33/00 - Antiparasitic agents
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The invention relates to novel algae of the Coccomyxa genus, in particular the algae of a novel species called Coccomyxa actinabiotis, and to the use thereof for metal uptake from aqueous media, and in particular from radioactive media.

IPC Classes  ?

• C12N 1/12 - Unicellular algaeCulture media therefor
• B09C 1/10 - Reclamation of contaminated soil microbiologically or by using enzymes
• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used
• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• C22B 3/18 - Extraction of metal compounds from ores or concentrates by wet processes with the aid of microorganisms or enzymes, e.g. bacteria or algae
• C22B 60/00 - Obtaining metals of atomic number 87 or higher, i.e. radioactive metals
• G21F 9/18 - Processing by biological processes

Abstract

The present invention relates to an in vitro method of diagnosis of a Plasmodium infection in a subject, by measuring the serum concentration of at least one secreted phospholipase A2 selected from the group consisting of GIIF, GV and GX sPLA2s, in said subject, from a blood sample. It also relates to a kit for carrying out said method and pharmaceutical compositions comprising a recombinant mammal GIIF, GV or GX sPLA2 or a combination thereof.

IPC Classes  ?

• G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a method for extracting organic molecules and/or organic minerals from a limestone material, including placing said limestone material in contact with a solution including at least one organic solvent, water and at least one acid, as well as to the organic molecules and/or organic minerals produced by the method. The products produced by the method can be used, for example, in therapeutic and non-therapeutic fields, in particular the agri-food, cosmetic and medical fields.

IPC Classes  ?

• B01D 11/02 - Solvent extraction of solids
• A61K 8/96 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution
• A61K 35/02 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials

Abstract

The invention relates to xanthone derivatives of formula (IA) or (IB) and their use for manufacturing a medicament for cancer, and in particular for chemotherapeutic resistant cancer. More particularly, the invention relates to compounds and compositions comprising such xanthone derivatives for the prevention and/or treatment for chronic leukemia and, for example, for chronic lymphocytic leukemia (CLL) or B-lymphoma.

IPC Classes  ?

• C07D 311/86 - Oxygen atoms, e.g. xanthones
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a fish protein hydrolysate containing molecules capable of exerting a satietogenic activity and of regulating food intake in humans or animals. More specifically, the protein hydrolysate according to the invention enables stimulation of the secretion of endogenous cholescystokinins (CCKs) and of endogenous glucagon-like peptide 1 (GLP1) molecules by intestinal cells and the supply of exogenous CCKs. The fish protein hydrolysate according to the invention is obtained by enzymatic hydrolysis of at least one protein source selected from the group composed of the pelagic fish species Micromesistius poutassou, Clupea harengus, Scomber scombrus, Sardina pilchardus, Trisopterus esmarki and Trachurus spp., the demersal fish species Gadus morhua, Pollachius virens, Melanogrammus aeglefinus and Coryphaenoides rupestris, and the species of fish belonging to the order Siluriformes, said enzymatic hydrolysis being carried out by means of a mixture of enzymes comprising endopeptidases derived from Bacillus amyloliquefaciens and from Bacillus licheniformis, or derived from Bacillus amyloliquefaciens, from Bacillus licheniformis and from Aspergillus oryzae.

IPC Classes  ?

• C12P 21/06 - Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
• A23J 3/34 - Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
• A61K 35/60 - Fish, e.g. seahorsesFish eggs
• A61K 38/01 - Hydrolysed proteinsDerivatives thereof
• C07K 14/595 - GastrinsCholecystokinins [CCK]

Abstract

The present invention relates to the use of oxygenated heterocycles chosen from among xanthones and biflavonoids for the preparation of a composition intended to act as an anti-coccidial agent, wherein the coccids are selected from the group made up of Eimeria, Isospora, Toxoplasma, Besnoitia and Neospora. In particular, the composition is for use in the prevention or treatment of coccidiosis in humans or animals. Advantageously, such a composition is for oral administration. The present invention also relates to a new compound of formula (Ia), laurentinone A.

IPC Classes  ?

• A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
• A23L 1/29 - Modifying nutritive qualities of foods; Dietetic products ( A23L 1/09 takes precedence;dietetic salt substitutes A23L 1/22)
• A61P 33/00 - Antiparasitic agents
• C07D 311/86 - Oxygen atoms, e.g. xanthones

Abstract

The invention relates to a Microbulbifer bacterial strain isolated from a marine sponge, to its use in a process for manufacturing paraben compounds. The invention also relates to paraben compounds obtained from that Microbulbifer strain and to their uses. The Microbulbifer strain of the invention is Microbulbifer strain named L4-N2 deposited at the CNCM under the registration number 1-3714. The process of manufacturing paraben compounds of the invention makes use of this Microbulbifer strain. The invention finds application in the manufacture of paraben compounds, for use in particular in cosmetic, pharmaceutical, antifouling, detergent, sanitizing and disinfectant compositions.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C12P 7/62 - Carboxylic acid esters
• A23L 1/00 - Foods or foodstuffs; Their preparation or treatment (preservation thereof in general A23L 3/00)
• A61K 8/00 - Cosmetics or similar toiletry preparations
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• C07C 67/00 - Preparation of carboxylic acid esters
• C11D 3/00 - Other compounding ingredients of detergent compositions covered in group
• C12R 1/01 - Bacteria or actinomycetales

Abstract

The present invention relates to an anti-gene oligonucleotide which specifically hybridizes with the gene coding for the human tyrosinase related protein-1 by Hoogsteen pairing between complementary bases, said oligonucleotide forming a triple helix structure with the human tyrosinase related protein-1 gene. The invention also relates to the use of said oligonucleotide as skin depigmenting or whitening agent in a cosmetic composition or a dermatological composition.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• A61K 8/73 - Polysaccharides
• A61Q 1/00 - Make-up preparationsBody powdersPreparations for removing make-up
• A61Q 5/08 - Preparations for bleaching the hair
• A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings

Abstract

The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumor cell nuclei in order to neutralize transiently their DNA repair capacity and trigger their death.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 35/00 - Antineoplastic agents
• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Abstract

The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumor cell nuclei in order to neutralize transiently their DNA repair capacity and trigger their death.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
• A61P 35/00 - Antineoplastic agents

Abstract

The invention concerns an antigenic oilgonucleotide hybridizing specifically with the gene encoding human tyrosinase through Hoogsteen pairing between complementary bases, said oligonucleotide forming a triple-helix structure with the human tyrosinase gene. The invention also concerns the use of said oligonucleotide as depigmenting or skin-whitening agent in a cosmetic composition or in a dermatological composition.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations
• A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
• A61P 17/00 - Drugs for dermatological disorders
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides

Abstract

The invention relates to double-stranded nucleic acid fragments comprising a chemically modified backdone and at least 4-1000 bp, preferably 8-500 bp, and most preferably 16-200 bp. The disclosed molecules (DRIL molecules) may interfere with DNA damage signalling and repair pathways, in particular the non homologous NHEJ pathway of double-stranded break repair. The invention discloses the application of the DRIL molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumoral cell nuclei in order to trigger DNA repair induced lethality (DRIL in short) of tumoral cells/tissues.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof