A medical device system includes an ambulatory medical device and a second device. The ambulatory medical device includes one or more physiologic sensors configured to output sensor data and a communication circuit to transmit the sensor data to another device. The second device includes another communication circuit configured to receive the sensor data from ambulatory medical device, and processing circuitry. The processing circuitry is configured to determine patterns of the sensor data consistent with hemodialysis treatments of the patient, identify a change in the patterns of the sensor data indicative of a change in the hemodialysis treatments, and produce an alert associated with the hemodialysis treatments in response to the determining the change in the patterns of the sensor data.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
2.
CONDUCTION SYSTEM PACING LEADS AND METHODS OF MANUFACTURING
An implantable lead includes a tubular lead body having proximal end, a distal end opposite the proximal end. A distal assembly includes an outer shell having a proximal portion and a distal portion. A tubular inner preform is disposed at least partially within the outer shell and includes a longitudinal slot extending from the distal end toward the proximal end, and a circumferential slot extending partially around a circumference of the inner preform. A coupler is disposed within the shell and includes a channel extending distally from the proximal end and an intermediate portion between the proximal and distal portions. The inner preform is coupled to the proximal portion of the coupler. A helical electrode is disposed about the distal portion of the coupler and a distal portion extends from the distal portion of the shell. A first conductor is mechanically and electrically coupled to the coupler.
An implantable lead includes a tubular lead body having proximal end, a distal end opposite the proximal end. A distal assembly includes an outer shell having a proximal shell component and a distal shell component. A coupler is disposed within the outer shell and includes a proximal portion having a proximal end and a first channel extending distally from the proximal end, and a distal portion opposite the proximal portion. The proximal shell component is mechanically coupled to the proximal portion of the coupler by a first snap-fit connection, and the distal shell component is mechanically coupled to the proximal portion of the coupler by a second snap-fit connection. A helical electrode is disposed about the distal portion of the coupler, and extends distally from the distal portion of the shell. First and second electrical conductors extend through the lead body and are coupled to the coupler.
An implantable lead includes a distal assembly having an outer shell having a proximal portion and a distal portion. A tubular inner preform may be disposed at least partially within the outer shell and includes a proximal end, a distal end opposite the proximal end, a longitudinal slot extending from the distal end toward the proximal end, and a circumferential slot extending partially around a circumference of the inner preform. A coupler made of an electrically conductive material is disposed within the shell and includes a longitudinal channel. The inner preform is mechanically coupled to the coupler. In embodiments, the shell may be snap fit to the coupler. A helical electrode having a proximal portion is disposed about the distal portion of the coupler, and a distal portion extends distally from the distal portion of the shell.
A tool for implanting a medical lead includes a body having distal region including a distal end, a proximal region including a proximal end, a central axis extending from the distal end to the proximal end, and a midpoint between the distal end and the proximal end. The distal region includes a rounded tip, and a distal lip surrounding a distal opening leading to a distal cavity dimensioned to receive and frictionally engage a connector component of the implantable lead. The proximal region includes a proximal lip surrounding a proximal opening leading to a proximal cavity. A chamber is located between the distal cavity and the proximal cavity. The tool includes a first window. A pair of resilient arms define at least a portion of the chamber and configured to frictionally engage a terminal pin of the implantable lead. The first window, chamber, and pair of resilient arms are located distal of the midpoint.
A battery can include an anode and a cathode enclosed within a battery housing, a feedthrough terminal coupled to one of the anode or the cathode and extending through a lid of the battery housing, and a glass insulator between the feedthrough terminal and the lid, wherein an outside surface of the lid and an outer surface of the feedthrough terminal and an outer surface of the glass insulator is covered by a first layer of an electrically insulative coating.
Embodiments herein relate to implantable chemical sensors. In an embodiment, an implantable optical chemical sensor includes a circuit board, at least one optical emitter, and at least one optical detector. The optical emitter can be disposed on the circuit board along with the optical detector. The optical chemical sensor can also include a floor plate and a well plate, the well plate defining at least one well and the well plate disposed over the floor plate. The well plate can include a vertical facet and a beveled facet disposed on a perimeter edge of the well plate. A feed-through flange can define a window with the vertical facet of the well plate fitting into the window. The optical emitter can emit light through the floor plate and into the well plate which is then redirected by the beveled facet into the well. Other embodiments are also included herein.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
8.
OPTO-ELECTRONIC HARDWARE CONFIGURATIONS FOR IMPLANTABLE CHEMICAL SENSORS
Embodiments herein relate to implantable chemical sensors. In an embodiment, an implantable optical chemical sensor includes a circuit board, at least one optical emitter, and at least one optical detector. The optical emitter can be disposed on the circuit board along with the optical detector. The optical chemical sensor can also include a floor plate and a well plate, the well plate defining at least one well and the well plate disposed over the floor plate. The well plate can include a vertical facet and a beveled facet disposed on a perimeter edge of the well plate. A feed-through flange can define a window with the vertical facet of the well plate fitting into the window. The optical emitter can emit light through the floor plate and into the well plate which is then redirected by the beveled facet into the well. Other embodiments are also included herein.
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
9.
DELIVERY DEVICES AND METHODS FOR LEADLESS CARDIAC DEVICES
Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may include a proximal section including a deflection mechanism for deflecting the proximal section, and a distal holding section extending distally of a distal end of the proximal section and defining a cavity therein for receiving an implantable leadless pacing device. The distal holding section may be structured to have portions that flex and bend while allowing the implantable device to be recaptured within the distal holding section.
An implantable medical device (IMD) that includes a first light emitter arranged to generate a first beam of emitted light, a second light emitter arranged to generate a second beam of emitted light, a light detector arranged to sense backscattered light, and at least one optical layer comprising a beam steering feature and/or a cross-talk feature.
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
An implantable medical device (IMD) that includes a first light emitter arranged to generate a first beam of emitted light, a second light emitter arranged to generate a second beam of emitted light, a light detector arranged to sense backscattered light, and at least one optical layer comprising a beam steering feature and/or a cross-talk feature.
A method includes storing, by one or more servers, separate packages of data received from separate medical devices. The separate packages of data are respectively associated with different patients. The method includes automatically determining which subset of the patients experiences the most health events among the different patients. Access to the packages of data is provided via a user interface, and an indicator is displayed on the user interface showing which of the patients is associated with the subset. A computing system such as a server can be programmed to carry out one or more steps of the method.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
Systems and methods for verifying cardiac pause episodes detected by a medical device are disclosed. A medical -device system comprises a physiological event detector to receive information about a cardiac pause episode detected by a medical device from a patient using a device-based, detection algorithm. The physiological event detector uses an algorithm different from the device-based, detection algorithm to generate one or more metrics including at least one entropy metric from the received information about the cardiac pause episode, and verify a presence or absence of cardiac pause in the device-detected cardiac pause episode using such metrics. The verified presence or absence of the cardiac pause may be presented to a user or a process to determine a. medical condition, such as a risk of syncope in the patient.
Systems and methods for verifying cardiac pause episodes detected by a medical device are disclosed. A medical-device system comprises a physiological event detector to receive information about a cardiac pause episode detected by a medical device from a patient using a device-based detection algorithm. The physiological event detector uses an algorithm different from the device-based detection algorithm to generate one or more metrics including at least one entropy metric from the received information about the cardiac pause episode, and verify a presence or absence of cardiac pause in the device-detected cardiac pause episode using such metrics. The verified presence or absence of the cardiac pause may be presented to a user or a process to determine a medical condition, such as a risk of syncope in the patient.
A61B 5/364 - Detecting abnormal ECG interval, e.g. extrasystoles or ectopic heartbeats
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
An implantable medical device (IMD) is configured with a pressure sensor. The IMD includes a housing and a diaphragm that is exposed to the environment outside of the housing. The diaphragm is configured to transmit a pressure from the environment outside of the housing to a piezoelectric membrane. In response, the piezoelectric membrane generates a voltage and/or a current, which is representative of a pressure change applied to the housing diaphragm. In some cases, only changes in pressure over time are used, not absolute or gauge pressures.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
Systems and methods are disclosed to determine and record one or more key metrics of atrial fibrillation for a patient, including determining indications of atrial fibrillation of the patient in respective detection windows of a day using received physiologic information, recording first physiologic information of the patient at a first sampling frequency for the determined indications of atrial fibrillation of the patient up to and not exceeding a first threshold of the medical device system for transmission to a remote device, and determining and recording one or more key metrics of atrial fibrillation for the determined indications of atrial fibrillation of the patient at a second sampling frequency lower than the first sampling frequency without regard to the first threshold.
Systems and methods are disclosed to determine and record one or more key metrics of atrial fibrillation for a patient, including determining indications of atrial fibrillation of the patient in respective detection windows of a day using received physiologic information, recording first physiologic information of the patient at a first sampling frequency for the determined indications of atrial fibrillation of the patient up to and not exceeding a first threshold of the medical device system for transmission to a remote device, and determining and recording one or more key metrics of atrial fibrillation for the determined indications of atrial fibrillation of the patient at a. second sampling frequency lower than the first sampling frequency without regard to the first threshold.
An ambulatory medical device includes a multi-axis posture sensor and processing circuitry. The multi -axis posture sensor is configured to provide an electrical posture sensor output representative of alignment of respective first, second, and third non-parallel axes of the ambulatory medical device with the gravitational field of the earth. The processing circuitry is configured to determine that the subject avoids lying on their left side using the posture sensor output, and compute a metric predictive of one or both of orthopnea and trepopnea in response to determining that the subject avoids lying on their left side.
Systems and methods are disclosed to an ambulatory medical device comprising a cardiac signal sensing circuit configured to sense a cardiac signal representative of cardiac activity of a patient when connected to electrodes, and a control circuit. The control circuit is configured to monitor cardiac depolarizations in the sensed cardiac signal, detect a bimodal distribution of heart rate of the patient, identify cardiac depolarization intervals shorter than a predetermined interval threshold, identify premature atrial contractions (PACs) in the sensed cardiac signal that are conducted normally and conducted aberrantly, and count a number of conducted PACs and produce an alert related to PC burden of the patient based on the number.
Systems and methods are disclosed to apply, in response to a detected atrial sense event in a first cardiac cycle, a ventricular blanking period for the first cardiac cycle and to detect a ventricular sense event in the first cardiac cycle using the received electrical information following the determined ventricular blanking period.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
21.
SYSTEM FOR PREMATURE ATRIAL CONTRACTION BURDEN ESTIMATION
Systems and methods are disclosed to an ambulatory medical device comprising a cardiac signal sensing circuit configured to sense a cardiac signal representative of cardiac activity of a patient when connected to electrodes, and a control circuit. The control circuit is configured to monitor cardiac depolarizations in the sensed cardiac signal, detect a bimodal distribution of heart rate of the patient, identify cardiac depolarization intervals shorter than a predetermined interval threshold, identify premature atrial contractions (PACs) in the sensed cardiac signal that are conducted normally and conducted aberrantly, and count a number of conducted PACs and produce an alert related to PC burden of the patient based on the number.
An ambulatory medical device includes a multi-axis posture sensor and processing circuitry. The multi-axis posture sensor is configured to provide an electrical posture sensor output representative of alignment of respective first, second, and third non-parallel axes of the ambulatory medical device with the gravitational field of the earth. The processing circuitry is configured to determine that the subject avoids lying on their left side using the posture sensor output, and compute a metric predictive of one or both of orthopnea and trepopnea in response to determining that the subject avoids lying on their left side.
Systems, devices and methods for determining sensing quality changes and drops in an implantable medical device, remotely and/or within the device itself. A cardiac implantable medical device tracks, over time, a number of counters, the contents of which are communicated to a processor which may be part of a remote monitoring device or which may be a customer service center that receives data from remote monitoring devices and/or programmers. Counter data is analyzed to identify changes in sensing quality and/or to provide information useful for clinical investigations, system integrity checking, or device reprogramming.
Systems, devices and methods for determining sensing quality changes and drops in an implantable medical device, remotely and/or within the device itself. A cardiac implantable medical device tracks, over time, a number of counters, the contents of which are communicated to a processor which may be part of a remote monitoring device or which may be a customer service center that receives data from remote monitoring devices and/or programmers. Counter data is analyzed to identify changes in sensing quality and/or to provide information useful for clinical investigations, system integrity checking, or device reprogramming.
A61N 1/372 - Arrangements in connection with the implantation of stimulators
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
Systems, methods, and devices involve approaches for limiting the number of detected cardiac events for which a physician is alerted. Approaches involve detecting cardiac events based on electrocardiogram (ECG) data and associating the cardiac events with a criticality. ECG data associated with a subset of the cardiac events is transmitted to a remote computing system based, at least in part, on the criticality. An electronic notification is transmitted to a patient care group regarding at least one of the cardiac events in the subset. Approaches further include determining whether an acknowledgement of the electronic notification has been received by the server from the patient care group within a set period of time.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
26.
ST ELEVATED MYOCARDIAL INFARCTION (STEMI) DETECTION IN INSERTABLE CARDIAC MONITOR
Systems and methods are disclosed to signal processing device of a patient management system. The signal processing device comprising a communication circuit configured to receive a cardiac signal from an AMD, wherein the received cardiac signal is a frequency filtered cardiac signal produced from a broader frequency band cardiac signal sensed using the AMD; signal processing circuitry configured to restore the received cardiac signal to the broader frequency band cardiac signal; detect an elevated ST segment in the restored broader frequency band cardiac signal; and generate an alert of myocardial infarction in response to detecting the elevated ST segment.
Systems and methods are disclosed to signal processing device of a patient management system. The signal processing device comprising a communication circuit configured to receive a cardiac signal from an AMD, wherein the received cardiac signal is a frequency filtered cardiac signal produced from a broader frequency band cardiac signal sensed using the AMD; signal processing circuitry configured to restore the received cardiac signal to the broader frequency band cardiac signal; detect an elevated ST segment in the restored broader frequency band cardiac signal; and generate an alert of myocardial infarction in response to detecting the elevated ST segment.
Systems, methods, and devices involve approaches for limiting the number of detected cardiac events for which a physician is alerted. Approaches involve detecting cardiac events based on electrocardiogram (ECG) data and associating the cardiac events with a criticality. ECG data associated with a subset of the cardiac events is transmitted to a remote computing system based, at least in part, on the criticality. An electronic notification is transmitted to a patient care group regarding at least one of the cardiac events in the subset. Approaches further include determining whether an acknowledgement of the electronic notification has been received by the server from the patient care group within a set period of time.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
29.
SLEEP DETECTION USING CARDIAC AND RESPIRATION INFORMATION
Systems and methods for monitoring and staging sleep using cardiac and respiration information are disclosed. An exemplary system comprises a storage device to store a trained hybrid sleep detection and classification model that comprise a plurality of trained machine-learning models each trained to map input cardiac and respiratory data into one of multiple distinct model-specific awake or sleep classes, and a trained regression model to combine the model- specific awake or sleep classes to a composite awake or sleep classification. A sleep detector applies patient cardiac and respiratory information to the trained hybrid sleep detection and classification model to determine a composite awake or sleep classification for the patient. The composite awake or sleep classification is used to diagnose medical conditions including sleep apnea.
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
30.
AORTIC STENOSIS SEVERITY QUANTIFICATION USING HEART SOUNDS
Systems and methods for monitoring and managing aortic stenosis are disclosed. An exemplary medical-device system comprises a data receiver to receive heart sound information sensed by ambulatory heart sound sensors, and a stenosis detector to detect a change in aortic valve surface area from a baseline stenosis-free state using heart sound components such as S1 and S2 sounds. Based on the change in aortic valve surface area, the stenosis detector can generate an aortic stenosis indicator indicating a presence and severity of aortic stenosis. Such indicator can be provided to a user, trigger symptom monitoring and evaluation of functional deterioration in the patient, facilitate assessment of patient candidacy for aortic valve replacement, or triage heart failure management strategies.
Systems and methods for monitoring and managing aortic stenosis are disclosed. An exemplary medical-device system comprises a data receiver to receive heart sound information sensed by ambulatory heart sound sensors, and a stenosis detector to detect a change in aortic valve surface area from a baseline stenosis-free state using heart sound components such as S1 and S2 sounds. Based on the change in aortic valve surface area, the stenosis detector can generate an aortic stenosis indicator indicating a presence and severity of aortic stenosis. Such indicator can be provided to a user, trigger symptom monitoring and evaluation of functional deterioration in the patient, facilitate assessment of patient candidacy for aortic valve replacement, or triage heart failure management strategies.
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/28 - Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
32.
SLEEP DETECTION USING CARDIAC AND RESPIRATION INFORMATION
Systems and methods for monitoring and staging sleep using cardiac and respiration information are disclosed. An exemplary system comprises a storage device to store a trained hybrid sleep detection and classification model that comprise a plurality of trained machine-learning models each trained to map input cardiac and respiratory data into one of multiple distinct model-specific awake or sleep classes, and a trained regression model to combine the model-specific awake or sleep classes to a composite awake or sleep classification. A sleep detector applies patient cardiac and respiratory information to the trained hybrid sleep detection and classification model to determine a composite awake or sleep classification for the patient. The composite awake or sleep classification is used to diagnose medical conditions including sleep apnea.
Embodiments herein relate to implantable medical devices. In an embodiment, an implantable medical device is included having a biocompatible housing, a control circuit that can disposed within the biocompatible housing, and a wireless communications transceiver. The wireless communications transceiver can be configured to communicate wirelessly through a first channel using a standard BLUETOOTH protocol (non-DSSS) and communicate wirelessly through a second channel using a direct sequence spread spectrum (DSSS) protocol over a BLUETOOTH frequency band. Other embodiments are also included herein.
Medical devices and methods for making and using medical devices are disclosed. An example medical device may include an implantable medical device. The implantable medical device may include an implantable pacing member having a housing and a lead input. A lead may be coupled to the lead input. The lead may be designed to extend along a pericardial space, epicardium, or both and engage a heart chamber. A passageway may be defined along a portion of the length of the lead.
Embodiments herein relate to optical chemical sensor systems that can be wearable and include microneedle arrays. In an embodiment, a chemical sensing device is included having a set of microneedles and a sensor element. The sensor element can include a first low-index gel layer, a second low-index gel layer, and a chromoionophore sensing film disposed between the first low-index gel layer and the second low-index gel layer. In an embodiment, a delay layer can be disposed between the sensor element and the set of microneedles. An optical emitter can be configured to emit light into the sensor element. An optical detector can be configured to receive light from the sensor element. Other embodiments are also included herein.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means
Embodiments herein relate to optical chemical sensor systems that can be wearable and include microneedle arrays. In an embodiment, a chemical sensing device is included having a set of microneedles and a sensor element. The sensor element can include a first low-index gel layer, a second low-index gel layer, and a chromoionophore sensing film disposed between the first low-index gel layer and the second low-index gel layer. In an embodiment, a delay layer can be disposed between the sensor element and the set of microneedles. An optical emitter can be configured to emit light into the sensor element. An optical detector can be configured to receive light from the sensor element. Other embodiments are also included herein.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
Embodiments herein relate to optical chemical sensor systems that can be wearable and include microneedle arrays. In an embodiment, a chemical sensing device can be included having an optical transmission layer. The optical transmission layer can define a plurality of microneedles. The chemical sensing device can include a plurality of sensor elements and one or more optical emitters, wherein the one or more optical emitters can be configured to emit light into the plurality of sensor elements. The chemical sensing device can also include a plurality of optical detectors, wherein the plurality of optical detectors can be configured to receive light from the plurality of sensor elements. Other embodiments are also included herein.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
38.
INVALID FEATURE MANAGEMENT FOR COMPOSITE HEALTH INDEX
Systems and methods are disclosed to determine a composite health index for the patient as a function of a plurality of features, including determining validity of a first feature of the plurality of features and adjusting the function used to determine the composite health index in response to a determination that the first feature is not valid.
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
Systems and methods are disclosed to determine a composite health index for the patient as a function of a plurality of features, including determining validity of a first feature of the plurality of features and adjusting the function used to determine the composite health index in response to a determination that the first feature is not valid.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
Systems and methods for cardiac pacing are described in this document. A medical system includes an electrostimulation circuit to generate His-bundle pacing (HBP) pulses to capture a His bundle, and LV pacing (LVP) pulses to capture a left ventricle. A sensing circuit may sense a cardiac activity, such as an atrial or an LV cardiac electrical activity. The system includes a control circuit controlling the delivery of HBP and LVP pulses. The HBP and LVP may be delivered concurrently or sequentially. In an example, the LVP pulses may be delivered based on a His-bundle capture status in response to the HBP pulse. The system may adjust one or more His-bundle stimulation parameters based on the His-bundle capture status.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
48.
IMPLANTABLE CHEMICAL SENSOR PACKAGES WITH CALIBRATION FEATURES
Embodiments herein relate to embodiments herein relate to packages for implantable chemical sensors with features to facilitate calibration of the sensors therein. In an embodiment, a chemical sensor system is included having a package and an implantable monitor device therein. The implantable monitor device can include an optical chemical sensor. A first aqueous solution including a solute can be disposed within the package. In some embodiments, the package includes a first chamber a second chamber separated by a frangible seal. A first aqueous solution can be disposed within the first chamber and a second aqueous solution can be disposed in the second chamber. Other embodiments are also included herein.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1495 - Calibrating or testing in vivo probes
49.
CONDUCTION SYSTEM PACING OPTIMAL OUTPUT SETTING INDICATOR
A method of operating a cardiac rhythm management (CRM) system includes sending a list of electrodes to an ambulatory medical device (AMD) of the CRM system from a programming device for the AMD, the list of electrodes including types of electrodes available to the AMD and position of the electrodes; sending a selection of one or more capture confirming criteria to confirm pacing capture to the AMD; performing, by the AMD, an automatic pacing threshold test for all potential pacing vectors that include the electrodes in the list of electrodes; collecting data for each pace of the pacing threshold test confirmed to capture according to the selected one or more capture confirming criteria; communicating the collected data to the programming device; and presenting the collected data as a trend relative to at least one selected capture confirming criterion and the pacing stimulation energy that resulted in capture.
A method of operating a cardiac rhythm management (CRM) system includes measuring a baseline PR interval of a cardiac depolarization; measuring one or both of a heart sound and a QRS width for the cardiac depolarization; delivering pacing stimulation according to an atrial sense to ventricular pace interval (AsVp interval) and measuring the one or both of the heart sound and the QRS width for the AsVp interval, wherein the pacing stimulation is delivered using a conduction system pacing (CSP) vector that includes an electrode positioned in an interventricular septum; delivering pacing stimulation according to an atrial pace to ventricular pace interval (ApVp interval) and measuring the one or both of the heart sound and the QRS width for the ApVp interval; and generating a recommended atrial to ventricular delay setting for CSP according to the measured one or both of the heart sounds and the QRS widths.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
51.
OPTIMIZING CONDUCTION SYSTEM PACING ATRIAL VENTRICULAR DELAYS
A method of operating a cardiac rhythm management (CRM) system includes measuring a baseline PR interval of a cardiac depolarization; measuring one or both of a heart sound and a QRS width for the cardiac depolarization; delivering pacing stimulation according to an atrial sense to ventricular pace interval (AsVp interval) and measuring the one or both of the heart sound and the QRS width for the AsVp interval, wherein the pacing stimulation is delivered using a conduction system pacing (CSP) vector that includes an electrode positioned in an interventricular septum; delivering pacing stimulation according to an atrial pace to ventricular pace interval (ApVp interval) and measuring the one or both of the heart sound and the QRS width for the ApVp interval; and generating a recommended atrial to ventricular delay setting for CSP according to the measured one or both of the heart sounds and the QRS widths.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
52.
CONDUCTION SYSTEM PACING OPTIMAL OUTPUT SETTING INDICATOR
A method of operating a cardiac rhythm management (CRM) system includes sending a list of electrodes to an ambulatory medical device (AMD) of the CRM system from a programming device for the AMD, the list of electrodes including types of electrodes available to the AMD and position of the electrodes; sending a selection of one or more capture confirming criteria to confirm pacing capture to the AMD; performing, by the AMD, an automatic pacing threshold test for all potential pacing vectors that include the electrodes in the list of electrodes; collecting data for each pace of the pacing threshold test confirmed to capture according to the selected one or more capture confirming criteria; communicating the collected data to the programming device; and presenting the collected data as a trend relative to at least one selected capture confirming criterion and the pacing stimulation energy that resulted in capture.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A method of manufacturing an implantable medical device having electrical components disposed within a cavity of a housing. The method comprises heating a gel filler material to a liquid, flowable state, depositing the gel filler material in the liquid, flowable state into the cavity to substantially encapsulate the electrical components within the gel filler material; and allowing the gel filler material to cool to a semi-solid state.
C08L 53/00 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers
C08L 91/00 - Compositions of oils, fats or waxesCompositions of derivatives thereof
61.
CANCER TREATMENT SYSTEMS WITH ENHANCED WAVEFORM GENERATING CIRCUITS
Embodiments herein relate to cancer treatment systems with electrical field generating circuits. In an embodiment, an implantable field generator device is included having a housing and a field-generating circuit disposed therein. The field-generating circuit can include a circuit ground, a positive voltage output, and a negative voltage output. An equivalent series referencing resistor is connected in series between a housing and the circuit ground. A first galvanic isolation switch and a first capacitor are connected in series between the positive voltage output and a positive electrode connection terminal. A second galvanic isolation switch and a second capacitor are connected in series between the negative voltage output and a negative electrode connection terminal. Other embodiments are also included herein.
A method includes detecting, using a medical device, a cardiac event based on a comparison of physiological data collected by the medical device to one or more programmed parameters of the medical device. The method further includes detecting, using the medical device, subevents associated with the cardiac event. The method further includes generating, using the medical device, metadata associated with the cardiac event and creating, using a computing system, a timeline of the cardiac event for display. The timeline includes icons associated with the subevents and including at least some of the metadata.
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Systems and methods for detecting and managing heart failure are discussed. A medical-device system receives heart sound information sensed from the patient, generates a heart sound metric using the received heart sound information, and generate a heart failure indicator indicating whether the patient has a heart failure with preserved ejection fraction (HFpEF) or a heart failure with reduced ejection fraction (HFrEF) based at least in part on the heart sound metric. The medical-device system can detect a transition from HFpEF to HFrEF. A therapy circuit can deliver or adjust a heart failure therapy in response to the detected transition from HFpEF to HFrEF.
Systems and methods for monitoring heart failure status in a patient are discussed. A medical-device system receives physiological and clinical information of the patient, and classifies the patient into one of a plurality of phenotypes using the received information. The plurality of phenotypes each can be characterized by a cluster physiological, clinical, demographic, or comorbidity features in a multi-dimensional feature space. Based on the classified phenotype, a heart failure detector determines a heart failure detection setting for the patient, and detects a heart failure status in the patient using the heart failure detection setting. A therapy circuit can deliver or adjust a heart failure therapy in response to the detected heart failure status.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
72.
INDIVIDUALIZED HEART FAILURE DIAGNOSTIC BASED ON COMORBIDITIES
Systems and methods for monitoring heart failure status in a patient are discussed. A medical-device system includes a storage device to store a correspondence between one or more heart failure comorbidities and corresponding one or more heart failure detection settings, and a heart failure detector circuit to detect a heart failure status of the patient. The heart failure detector circuit receives physiological information and heart failure comorbidity information of the patient, determines a detection setting for the patient based on the received comorbidity information and the stored correspondence, and detect a heart failure status using the received physiological information and the identified detection setting. A therapy circuit can deliver or adjust a heart failure therapy in response to the detected heart failure status.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
Systems and methods for monitoring patients with a chronic disease such as heart failure are disclosed. The system may include a physiological sensor circuit to sense physiological signals and generate signal metrics from the physiological signals. The system may include a health status analyzer circuit to use the signal metrics to generate one or more stability indicators of patient health status, such as stability of heart failure status. The system may additionally generate one or more health status indicators indicating patient health status such as heart failure progression. A patient disposition decision may be generated using the health status indicators and the stability indicators to provide an indication of readiness for patient discharge from or a risk of admission to a hospital.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
A61B 5/08 - Measuring devices for evaluating the respiratory organs
An apparatus for use in manufacturing a component of an implantable medical device comprises a fixture comprising a first fixture member having a plurality of semi-circular recesses in a lower surface thereof, and a second fixture member having a plurality of semi-circular recesses in an upper surface thereof, the first and second fixture members being configured to be selectively fastened together via a plurality of fasteners, wherein in an assembled state of the fixture, each of the semi-circular recesses of the first fixture member lower surface is aligned with an opposing semi-circular recess in the second fixture member upper surface to define a plurality of workpiece openings each dimensioned to receive and secure a respective work piece to be machined to the fixture.
An apparatus for use in manufacturing a component of an implantable medical device comprises a fixture comprising a first fixture member having a plurality of semi-circular recesses in a lower surface thereof, and a second fixture member having a plurality of semi-circular recesses in an upper surface thereof, the first and second fixture members being configured to be selectively fastened together via a plurality of fasteners, wherein in an assembled state of the fixture, each of the semi-circular recesses of the first fixture member lower surface is aligned with an opposing semi-circular recess in the second fixture member upper surface to define a plurality of workpiece openings each dimensioned to receive and secure a respective work piece to be machined to the fixture.
Methods of manufacturing an implantable medical device, and devices resulting from such methods. A printed circuit board assembly is made, and a first portion of encapsulant is applied to at least a portion of the printed circuit board assembly. A flex circuit is attached, such as by soldering, to the printed circuit board assembly. The flex circuit is then secured to the first portion of encapsulant, prior to applying a second portion of encapsulant.
A method of controlling operation of a medical device includes delivering electrical cardiac pacing energy to a left conduction bundle branch (LBB) area of the subject according to a primary pacing mode that uses a tip electrode of an implantable cardiac lead connected to the medical device for cathodal capture in the LBB area; monitoring for loss of cathodal capture of the LBB area when delivering the electrical cardiac pacing energy in the primary pacing mode; and changing to a backup pacing mode when the loss of cathodal capture is detected, wherein the backup pacing mode uses a ring electrode of the implantable cardiac lead for anodal capture in an interventricular septum of the subject.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A method of controlling operation of a medical device includes delivering electrical cardiac pacing energy to a left conduction bundle branch (LBB) area of the subject according to a primary pacing mode that uses a tip electrode of an implantable cardiac lead connected to the medical device for cathodal capture in the LBB area; monitoring for loss of cathodal capture of the LBB area when delivering the electrical cardiac pacing energy in the primary pacing mode; and changing to a backup pacing mode when the loss of cathodal capture is detected, wherein the backup pacing mode uses a ring electrode of the implantable cardiac lead for anodal capture in an interventricular septum of the subject.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A method of operating a cardiac rhythm management (CRM) system includes recurrently calculating, by a medical device of the CRM system, impedances between a housing electrode included in a housing of the medical device and each of multiple pacing electrodes, wherein the multiple pacing electrodes include a left bundle branch pacing electrode configured for placement in a left bundle branch of a subject; comparing the calculated impedances to one or more specified impedance values; and producing an alert regarding placement of a pacing electrode in response to a calculated impedance corresponding to the pacing electrode differing from the one or more specified impedance values by a predetermined threshold impedance value.
Embodiments of the present disclosure relate to implantable medical devices. According to an exemplary embodiment, a method for forming an electrode on an implantable medical device (IMD), comprises forming a nonconductive body comprising a well having a bottom surface and at least one side surface extending from the bottom surface. The method further comprises forming a conduit through the bottom surface and inserting the nonconductive body into an opening in an external surface of the IMD. The method also comprises depositing conductive material into the well and coupling the conductive material to a circuit of the IMD via the conduit through the bottom surface of the well.
Methods of manufacturing a medical device, and medical devise made by such methods. One or more layers or portions of encapsulant are used to secure components of a medical device in a housing. The case fit-up of the device may be modified to reduce reliance on size tolerances of components of the medical device, while still accounting for any anticipated changes in component size due to aging.
H01M 50/202 - Casings or frames around the primary casing of a single cell or a single battery
H01M 50/242 - MountingsSecondary casings or framesRacks, modules or packsSuspension devicesShock absorbersTransport or carrying devicesHolders characterised by physical properties of casings or racks, e.g. dimensions adapted for protecting batteries against vibrations, collision impact or swelling
H01M 50/247 - MountingsSecondary casings or framesRacks, modules or packsSuspension devicesShock absorbersTransport or carrying devicesHolders specially adapted for portable devices, e.g. mobile phones, computers, hand tools or pacemakers
H01M 50/284 - MountingsSecondary casings or framesRacks, modules or packsSuspension devicesShock absorbersTransport or carrying devicesHolders with incorporated circuit boards, e.g. printed circuit boards [PCB]
An implantable stimulator can control delivery of the neurostimulation to a patient according to a stimulation configuration and adjust the stimulation configuration by using a closed-loop control algorithm. In an example, the system may include a remote controller (RC) configured for use by the patient. The RC may transmit stimulator adjustment information to the implantable stimulator. The stimulator adjustment information may include direct control adjustment information for adjusting the stimulation configuration and adaptation adjustment information for adjusting the closed-loop control algorithm. The RC may generate the stimulator adjustment information based on patient adjustment instructions. The RC includes a user interface configured to receive a patient input and to determine the patient adjustment instructions by interpreting the patient input according to an RC configuration that is programmable for modifying capabilities of the RC in adjusting the stimulation configuration and adjusting the closed-loop control algorithm.
Systems and methods are disclosed to adjust one or more determined boundaries of a display of received physiologic information of a patient based on different first and second ranges of physiologic information, including determining first and second boundaries of a first range of the received physiologic information and first and second boundaries of a second range of the received physiologic information, wherein the second range is within the first range. The one or more determined boundaries of the display can be provided for presentation to a user, including the determined first and second boundaries of the first range and the determined first and second boundaries of the second range.
Implantable medical devices including a housing that contains operational circuitry for the implantable medical device and a dispensed hydrogen getter. The hydrogen getter may include a getter carrier material and one or more getter materials carried as suspensions in the getter carrier material, with the getter materials taking the form of organic compounds, such as fatty acids, or powdered metal oxides, or combinations thereof. The hydrogen getter may instead be comprised of two fatty acids having different melt temperatures. The hydrogen getter may be dispensed onto an encapsulant layer or other component of the implantable medical device, or may be blended into an encapsulant layer.
Systems and methods are disclosed to absorb a portion of a positive or negative manufacturing tolerance of at least one component of a stacked bore assembly are disclosed, the stacked bore assembly comprising a first component having a distal mechanical feature and a second component having a proximal mechanical feature configured to engage the distal mechanical feature the first component to a shoulder on a first one of the distal mechanical feature of the first component or the proximal mechanical feature of the second component. The shoulder can be positioned at a distance from an end of the first one of the distal mechanical feature of the first component or the proximal mechanical feature of the second component shorter or longer than a length of a second of the distal mechanical feature of the first component or the proximal mechanical feature of the second component.
A connector apparatus for a medical device includes connector apparatus of a medical device to provide electrical contact to at least one conductive lead, the apparatus comprising: at least one lead receptacle including an opening to receive the at least one conductive lead, wherein the at least one lead receptacle includes: at least a first electrode to contact the at least one conductive lead when the conductive lead is inserted into the lead receptacle; and a moveable visual indicator to be moved to become visible through the connector apparatus when the at least one conductive lead is inserted in the lead receptacle and contacts the at least one electrode.
A61N 1/375 - Constructional arrangements, e.g. casings
H01R 13/405 - Securing in non-demountable manner, e.g. moulding, riveting
H01R 13/641 - Means for preventing, inhibiting or avoiding incorrect coupling by indicating incorrect couplingMeans for preventing, inhibiting or avoiding incorrect coupling by indicating correct or full engagement
H01R 43/20 - Apparatus or processes specially adapted for manufacturing, assembling, maintaining, or repairing of line connectors or current collectors or for joining electric conductors for assembling or disassembling contact members with insulating base, case or sleeve
Systems and methods are disclosed to absorb a portion of a positive or negative manufacturing tolerance of at least one component of a stacked bore assembly are disclosed, the stacked bore assembly comprising a first component having a distal mechanical feature and a second component having a proximal mechanical feature configured to engage the distal mechanical feature the first component to a shoulder on a first one of the distal mechanical feature of the first component or the proximal mechanical feature of the second component. The shoulder can be positioned at a distance from an end of the first one of the distal mechanical feature of the first component or the proximal mechanical feature of the second component shorter or longer than a length of a second of the distal mechanical feature of the first component or the proximal mechanical feature of the second component.
Systems and methods are disclosed to adjust one or more determined boundaries of a display of received physiologic information of a patient based on different first and second ranges of physiologic information, including determining first and second boundaries of a first range of the received physiologic information and first and second boundaries of a second range of the received physiologic information, wherein the second range is within the first range. The one or more determined boundaries of the display can be provided for presentation to a user, including the determined first and second boundaries of the first range and the determined first and second boundaries of the second range.
An ambulatory medical device includes an energy storage component having a metal case and one output pin; a circuit board including a supply connection and a ground connection; a first conductive wire connected to the supply connection of the circuit board and the output pin of the energy storage component; and a second conductive wire connected to the ground connection of the circuit board and the metal case of the energy storage component.
H01M 50/213 - Racks, modules or packs for multiple batteries or multiple cells characterised by their shape adapted for cells having curved cross-section, e.g. round or elliptic
H01M 50/247 - MountingsSecondary casings or framesRacks, modules or packsSuspension devicesShock absorbersTransport or carrying devicesHolders specially adapted for portable devices, e.g. mobile phones, computers, hand tools or pacemakers
H01M 50/545 - Terminals formed by the casing of the cells
H01M 50/562 - Terminals characterised by the material
H01R 43/02 - Apparatus or processes specially adapted for manufacturing, assembling, maintaining, or repairing of line connectors or current collectors or for joining electric conductors for soldered or welded connections
91.
IMPLANTABLE MEDICAL SYSTEMS FOR CANCER TREATMENT WITH ELECTRODES FOR THERMAL MANAGEMENT
Embodiments herein relate to implantable systems for cancer treatment including electrodes that can aid in thermal management. In an embodiment, an implantable lead for a cancer treatment system is included having a lead body with a proximal end and a distal end. The lead body can define sides of a tissue exclusion channel. The lead can include one or more supply electrodes, wherein the electrodes are disposed along a length of the lead body. The tissue exclusion channel can be disposed circumferentially around the electrodes. Other embodiments are also included herein.
Embodiments herein relate to implantable chemical sensors for detecting a physiological analyte and medical devices including the same. In an embodiment, an implantable medical device is included. The implantable medical device can include a chemical sensor configured to detect an ion concentration in a bodily fluid. The chemical sensor can include a sensing element. The sensing element can include an outer barrier layer forming a top, a bottom, and opposed sides of the sensing element and a structural reinforcing element contacting the outer barrier layer. The top of the outer barrier layer of the sensing element can include a polymeric matrix permeable to analytes.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
Systems and methods for detecting a blockage in a patient's cardiac conduction system using heart sound information is disclosed. An exemplary medical-device system includes a data receiver circuit to receive heart sound information sensed from a patient, and a controller circuit to generate a heart sound metric or characteristic from the received heart sound information. The heart sound metric can include one indicative of a presence or absence of split S1 sound. The controller circuit can detect a bundle branch block (BBB), including to discriminate a left bundle branch block (LBBB) from a right bundle branch block (RBBB), based at least in part on the heart sound metric. The BBB indicator can be provided to a user or a process executable by the medical-device system to optimize cardiac pacing and restore cardiac synchrony.
Systems and methods for detecting a blockage in a patient's cardiac conduction system using heart sound information is disclosed. An exemplary medical-device system includes a data receiver circuit to receive heart sound information sensed from a patient, and a controller circuit to generate a heart sound metric or characteristic from the received heart sound information. The heart sound metric can include one indicative of a presence or absence of split S1 sound. The controller circuit can detect a bundle branch block (BBB), including to discriminate a left bundle branch block (LBBB) from a right bundle branch block (RBBB), based at least in part on the heart sound metric. The BBB indicator can be provided to a user or a process executable by the medical-device system to optimize cardiac pacing and restore cardiac synchrony.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A61N 1/372 - Arrangements in connection with the implantation of stimulators
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
Hydrogen getters are provided in active implantable medical device by applying a layer of selected metal with a chosen thickness over an un-oxidized portion of a base metal. The base metal may be titanium, and the selected metal may be palladium or platinum, with a thickness of less than 250 nanometers, where the selected metal acts as a passivation layer relative to oxidation but allows hydrogen capture by the base metal. The getter may be a separate component or may be formed as part of an existing component such as a feedthrough ferrule.
Implantable medical devices are constructed with a dampening layer to limit motion of components inside a housing of the implantable medical devices. The dampening layer may have features to provide thermal isolation for certain components. The dampening layer may have features to allow mechanical vibration of selected components. The dampening layer may have features to ensure an air space exists to enable a residual gas analysis test.
Implantable medical devices with a dampening layer, and methods for manufacturing such devices. A dampening layer may be dispensed onto assembled electrical components of an implantable medical device. The dampening layer may include a first material which is modified with a second material to reduce one or more of the heat capacity or density thereof.
A medical device includes a first housing section with a first cavity and including a ceramic material, a second housing section coupled to the first housing section and including a second cavity, a first circuit board section positioned within the first cavity, a second circuit board section positioned within the second cavity, and an antenna coupled to the first circuit board section.
An implantable medical device includes a metal case having a hermetic seal; and an identification (ID) tag arranged within the sealed metal case, wherein the ID tag is readable by X-raying the device.
A medical device includes a first housing section with a first cavity and including a ceramic material, a second housing section coupled to the first housing section and including a second cavity, a first circuit board section positioned within the first cavity, a second circuit board section positioned within the second cavity, and an antenna coupled to the first circuit board section.
