Abstract

The present invention provides a process for nitrating aromatic compounds without the need for a solid catalyst and/or any organic solvents and/or any other additives. A typical process includes combining or admixing a nitric acid and an anhydride compound under conditions sufficient to produce a reactive intermediate. The aromatic compound to be nitrated is then added to this reactive intermediate to produce a nitroaromatic compound. The nitroaromatic compound can be substituted with one or more, typically, one to three, and often one or two nitrate (-NO2) groups.

IPC Classes  ?

• C07C 201/02 - Preparation of esters of nitric acid
• C07C 205/37 - Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom

Abstract

The present invention provides compositions and methods for treating cognitive impairment or dysfunction in a subject. In particular, the present invention provides a method for using a composition comprising an angiotensin-(1-7) receptor agonist to treat cognitive dysfunction or impairment that is due to a various clinical conditions including, but not limited to, those associated with increase in inflammation, cytokine production, increases in reactive oxygen species, changes in expression of brain inflammatory related genes and/or in the expression of genes involved in learning and memory within the central nervous system of a subject.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• A61P 9/12 - Antihypertensives
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings

Abstract

The present invention provides a carbon fiber that is coated with a composite material. The composite material coating comprises a sulfonated tetrafluoroethylene based ionomer. The present invention also provides a method for producing and using the same. Some aspects of the invention provide a carbon fiber comprising a substantially uniformly coated composite material. In some embodiments, the term "substantially uniformly coated" refers to having a variation of thickness of the coating of about 25% or less, typically about 20% or less, often about 15% or less, more often about 10% or less, and most often about 5% or less throughout at least about 90%, typically at least about 95% and most often at least 98% of the length of the coated carbon fiber.

IPC Classes  ?

• H01M 4/04 - Processes of manufacture in general

Abstract

The present invention provides a method for determining ease of usability of an interactive program or software. In particular, one or more of the input device usage characteristics are used to determine the ease of usability. Using the methods of the invention, one can determine the ease of use between different versions of a program and/or different arrangements of interactive tasks within a program.

IPC Classes  ?

• G06F 11/36 - Prevention of errors by analysis, debugging or testing of software
• G06F 11/26 - Functional testing

Abstract

The present invention provides a method for treating a clinical condition associated with underexpression of BCL2 gene. In particular, the present invention provides a method for treating a clinical condition associated with underexpression of BCL2 gene by administering a compound that increases i-motif structure of BCL2 gene thereby increasing the expression of BCL2 gene.

IPC Classes  ?

• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/4453 - Non-condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
• A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention provides a method for treating a clinical condition associated with overexpression of BCL2 gene. In particular, the present invention provides a method for treating a clinical condition associated with overexpression of BCL2 gene by administering a compound that reduces i-motif structure of BCL2 gene.

IPC Classes  ?

• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/4453 - Non-condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
• A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention provides isolated polypeptides having nitrile hydratase activity and isolated polynucleotides encoding said polypeptides. The invention also provides nucleic acid constructs, vectors, and host cells comprising said polynucleotides as well as methods of producing and using said polypeptides.

IPC Classes  ?

• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material

Abstract

The present invention provides a system and a method for detecting or determining a possible fraudulent information provided by a subject using the subject's behavioral biometric during an application filing process using an electronic input device.

IPC Classes  ?

• A61B 5/16 - Devices for psychotechnicsTesting reaction times

Abstract

The present invention provides compounds that are soluble in a non-polar solvent and having a low ionization energy and negative oxidation potentials in tetrahydrofuran (THF). The present invention also provides a method for producing and using the same.

IPC Classes  ?

• C07F 11/00 - Compounds containing elements of Groups 6 or 16 of the Periodic Table
• C07D 487/04 - Ortho-condensed systems

Abstract

The present invention provides a various three-dimensional polymeric scaffold and methods for producing and using the same. In one embodiment, the three-dimensional polymeric scaffold is used to promote cell migration. Yet in another embodiment, the three- dimensional polymeric scaffold comprises enhanced surface functionalization. In one particular embodiment, the polymeric scaffold comprises a plurality of polymer layers, wherein each polymer layer comprises microchannels. Still in another particular embodiment, the composition comprises a fibrous cholesteryl succinyl silane. Yet in another particular embodiment, a polymer comprising cholesteryl succinyl silane attached (e.g., hybridized) to its surface is provided.

IPC Classes  ?

• C12N 11/08 - Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer

Abstract

The present invention provides compositions and methods for treating cognitive impairment or dysfunction in a subject. In particular, the present invention provides a method for using a composition comprising an angiotensin-(l-7) receptor agonist to treat cognitive dysfunction or impairment that is due to a various clinical conditions including, but not limited to, those associated with increase in inflammation, cytokine production, increases in reactive oxygen species, changes in expression of brain inflammatory related genes and/or in the expression of genes involved in learning and memory within the central nervous system of a subject.

IPC Classes  ?

• A61K 38/08 - Peptides having 5 to 11 amino acids

Abstract

The present invention provides a system and a method for establishing user identities through continuously monitoring input device usage. In some embodiments, the present invention provides a system and a method for computer user profiling based on behavioral biometrics. The method generally comprises establishing profiles of a particular computer user based on how and the way an input device is used.

IPC Classes  ?

• G06F 7/04 - Identity comparison, i.e. for like or unlike values

Abstract

The present invention provides a system and a method for detecting a neuromotor disorder or condition in a subject using an electronic device that comprises an input device. The method generally involves determining input device usage characteristics of the subject and comparing the result to a reference input device usage characteristic.

IPC Classes  ?

• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition

Abstract

The present invention relates to a system and a method of detecting or determining anomalous behavior in a subject using the subject's behavioral biometric and the subject's behavioral system usage activity pattern.

IPC Classes  ?

• G06F 1/00 - Details not covered by groups and
• G06F 21/00 - Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity

Abstract

The present invention provides a system and a method for eliciting information to sensitive questions and reliably detecting whether one is being deceptive, concealing information, or experiencing a heightened emotional response to the question. In particular, the system and the method of the invention are based on analyzing the user behavioral biometric of using one or more input device(s).

IPC Classes  ?

• G06F 21/00 - Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity

Abstract

The present invention provides a microfluidic device for preparing or extracting a biological sample from a solid material and methods for using the same. The microfluidic device of the invention automates the biological sample extraction from a solid material, thereby significantly reducing the possibility of contamination, human error and a potential variability of the sample that is obtained by different technicians.

IPC Classes  ?

• G01N 1/02 - Devices for withdrawing samples

Abstract

This invention provides an apparatus for electrically stimulating a cell and a method for using the same. In particular, the apparatus of the invention comprises an array of electrodes and a controller for actuating individual electrodes.

IPC Classes  ?

• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

A system and method for analyzing the dynamics of fluid layers on contact lenses utilizes phase shifting interferometry to quickly and accurately model the time-evolution of the fluid layers. The system and method are utilized for in vitro studies.

IPC Classes  ?

• G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures

Abstract

A slab type laser apparatus has a slab type gas laser medium part formed in a region defined by a pair of electrode flat plates oppositely disposed in parallel with each other in a space to be filled with a gas laser medium which is excited by high-frequency electric power. The apparatus includes an oscillator part including a pair of resonator mirrors oppositely disposed with a part of the gas laser medium part in between, and for amplifying a laser beam to have predetermined light intensity to emit the laser beam, and the amplifier part including a plurality of return mirrors oppositely disposed with a part of the gas laser medium part in between. The incident laser beam goes and returns plural times between the return mirrors, and the laser beam is amplified to have predetermined power.

IPC Classes  ?

• H01S 3/22 - Gases