A carboxylic acid-type lipid can accelerate adhesion or aggregation of platelets even if the carboxylic acid-type lipid does not carry a protein involved in adhesion or aggregation of platelets or a peptide corresponding to an active site of the protein; a lipid particle and a lipid membrane each include the carboxylic acid-type lipid; and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane. A carboxylic acid-type lipid is selected from carboxylic acid-type lipids represented by formulas (I) to (VI), a lipid particle includes the carboxylic acid-type lipid, a lipid membrane includes the carboxylic acid-type lipid, and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane.
C07C 233/47 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
2.
CARBOXYLIC ACID-TYPE LIPID, AND LIPID PARTICLE AND LIPID MEMBRANE CONTAINING CARBOXYLIC ACID-TYPE LIPID
The purpose of the present invention is to provide: a carboxylic acid-type lipid which can promote adhesion and coagulation of platelets without carrying a protein or peptide (e.g., GPIb or H12) which is involved in adhesion or coagulation of platelets; lipid particles containing the carboxylic acid-type lipid; a lipid membrane containing the carboxylic acid-type lipid; and a platelet coagulation promoting agent, a platelet adhesion promoting agent, a hemostatic agent, and a platelet alternative which contain the carboxylic acid-type lipid, the lipid particles, or the lipid membrane. To achieve the purpose, the present invention provides: a carboxylic acid-type lipid selected from carboxylic acid-type lipids represented by formulae (I) to (VI); lipid particles containing the carboxylic acid-type lipid; a lipid membrane containing the carboxylic acid-type lipid; and a platelet coagulation promoting agent, a platelet adhesion promoting agent, a hemostatic agent, and a platelet alternative which contain the carboxylic acid-type lipid, the lipid particles, or the lipid membrane.
C07C 233/05 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
The purpose of the present invention is to provide a lipid-containing hemostatic material capable of promoting adhesion or agglutination of platelets even without having a protein or a peptide supported thereon, such as GPIb and H12, involved in for adhesion or agglutination of platelets. In order to accomplish said purpose, provided is a hemostatic material (10) provided with a water-insoluble base material (1) and a lipid supported on the surface of the base material (1), wherein the lipid comprises one or more types of anionic lipid.
A61L 15/20 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61L 15/26 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bondsDerivatives thereof
A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-μm-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-μm-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.
A61P 41/00 - Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
C08G 65/26 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
A porous ultra-thin polymer film has a film thickness of 10 nm-1000 nm. A method of producing the porous ultra-thin polymer film includes dissolving two types of mutually-immiscible polymers in a first solvent in an arbitrary proportion to obtain a solution; applying the solution onto a substrate and then removing the first solvent from the solution applied onto the substrate to obtain a phase-separated ultra-thin polymer film that has been phase-separated into a sea-island structure; and immersing the ultra-thin polymer film in a second solvent which is a good solvent for the polymer of the island parts but a poor solvent for a polymer other than the island parts to remove the island parts, thereby obtaining a porous ultra-thin polymer film.
C08J 9/26 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
Provided is an anti-conglutination material that has an operability that allows reliable attachment thereof to biological tissue and in which tissue adhesiveness and biodegradability are improved. The anti-conglutination material has a water-soluble support layer that contains a water-soluble polymer and that has a thickness of 1-1000 μm and an anti-conglutination layer that contains a biodegradable polymer and that has a thickness of 1-1000 μm, wherein the biodegradable polymer has a structure in which a branched polyalkylene glycol having three to eight terminal hydroxyl groups per molecule and a polyhydroxyalkanoic acid are bonded, and the proportion of the mass of the branched polyalkylene glycol relative to the total mass is 1-30%.
A polymer film can be adjusted to movement or a fine uneven surface of a living body and has excellent ability to adhere to a biological tissue. The polymer film includes a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, wherein the polymer film has a film thickness of 10 to 1000 nm. The branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule, the mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%, and a value obtained by dividing the average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000.
C08G 81/02 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
C08G 63/06 - Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxy carboxylic acids
C08G 63/664 - Polyesters containing oxygen in the form of ether groups derived from hydroxycarboxylic acids
C08L 53/00 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers
A61L 27/00 - Materials for prostheses or for coating prostheses
A61L 31/00 - Materials for other surgical articles
A61L 15/00 - Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
C08G 81/00 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
C08G 65/332 - Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides or esters thereof
Provided is a self-supporting thin film having strong adhesiveness in which an increase in adhesion due to thinning and an increase in adhesive force due to polyphenol coating act synergistically by coating a self-supporting thin film with polyphenol. The self-supporting thin film can be used as a biocompatible thin film. Also provided is a method for producing a self-supporting thin film comprising silicone prior to polyphenol coating, wherein the method for producing a silicone self-supporting thin film having a high aspect ratio, elastic modulus, and adhesiveness uses a solvent having a specific polarity as the solvent that dissolves the main agent and the curing agent during a crosslinking reaction to form a non-water-soluble polymer thin film.
The purpose of the present invention is to provide a polymer film which can conform to movements of the living body or to fine ruggedness and further has excellent adhesion to biotissues. The present invention provides a polymer film which has a thickness of 10-1,000 nm and comprises a block copolymer having a structure in which a branched poly(alkylene glycol) and a poly(hydroxyalkanoic acid) have been bonded to each other. The branched poly(alkylene glycol) has three or more terminal hydroxyl groups per molecule. The proportion of the mass of the branched poly(alkylene glycol) to the whole mass of the block copolymer is 1-30%. When the average molecular weight of the poly(hydroxyalkanoic acid) contained in the block copolymer is divided by the number X of the terminal hydroxyl groups possessed by the branched poly(alkylene glycol) per molecule, then the quotient is 10,000-30,000.
C08G 65/332 - Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides or esters thereof
A61L 15/00 - Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
A61L 27/00 - Materials for prostheses or for coating prostheses
A61L 31/00 - Materials for other surgical articles
A61P 41/00 - Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
C08G 81/00 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
Provided are: a polymer film characterized in that the average film thickness T0 along a straight line D passing through the center of gravity of a two-dimensional maximum-area projection satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation Δ defined by equation (d) satisfies equation (e); and a liquid dispersion and an agglomerate using the same. (a) 10 nm ≦ T0 ≦ 1000 nm, (b)0.1 µm ≦ L ≦ 500 µm, (c) 0.01 GPa ≦ E ≦ 4.3 GPa, (d) Δ=1-T1/T2, (e) 0.346E×10-9-1.499 < Δ < -0.073E×10-9+0.316. According to the present invention, a polymer film which is easy to handle and has excellent compatibility, coatability, adhesiveness, and adhesion with respect to organ tissues; and a liquid dispersion and an agglomerate using the same can be provided.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A61L 31/00 - Materials for other surgical articles
The purpose of the present invention is to provide a laminated film that is highly biocompatible and easy to handle, has good stickiness and adhesiveness to an organ tissue and rarely induces infections. The laminated film provided by the present invention, which comprises a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on one surface of the polylactic acid-based resin layer, is highly flexible and easy to handle, and, when stuck to an adherend with curved surface, the laminated film shows excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be easily removed with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. Moreover, the acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs, etc. Thus, the laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.
Our invention is a laminate film comprising a water-soluble resin layer and a polylactic acid-based resin layer laminated on at least one side of a substrate film, the water-soluble resin layer has a thickness of 0.1 to 15 μm, the polylactic acid-based resin layer has a thickness of 10 to 500 nm. Such a configuration provides a laminate film of which the water-soluble resin layer and the polylactic acid-based resin layer are easily separated from the substrate film and which is excellent in coating ability, adherence and followability to a soft and curved adherend, as well as compatibility to skin and organs such as viscera, so as to be suitable for wound dressing, adhesion prevention material and a skin external agent such as skin-care product.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
B32B 3/30 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids characterised by a layer formed with recesses or projections, e.g. grooved, ribbed
B32B 7/02 - Physical, chemical or physicochemical properties
A61L 15/64 - Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
A61L 15/24 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bondsDerivatives thereof
A61L 15/26 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bondsDerivatives thereof
The objective of the present invention is to provide a porous ultra-thin polymer film, and a method for producing said porous ultra-thin polymer film. The present invention provides a porous ultra-thin polymer film with a film thickness of 10 nm-1000 nm. In addition, the present invention provides a method for producing a porous ultra-thin polymer film, comprising the steps of: dissolving two types of mutually-immiscible polymers in a first solvent in an arbitrary proportion to obtain a solution; applying the solution onto a substrate and then removing the first solvent from the solution applied onto the substrate to obtain a phase-separated ultra-thin polymer film that has been phase-separated into a sea-island structure; and immersing the ultra-thin polymer film in a second solvent which is a good solvent for the polymer of the island parts but a poor solvent for a polymer other than the island parts to remove the island parts, thereby obtaining a porous ultra-thin polymer film.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
B82Y 40/00 - Manufacture or treatment of nanostructures
Provided is a laminate film characterized by laminating at least one each of a water soluble resin layer and a polylactic acid resin layer at least at one surface of a substrate film, the thickness of the water soluble resin layer being 0.1-15 μm, and the thickness of the polylactic acid resin layer being 10-500 nm. By means of such a configuration, it is possible to obtain a laminate film that is optimal as an external preparation for skin such as a wound covering agent, and antiadhesive agent, or a skin care article, and that is such that the water soluble resin layer and the polylactic acid resin layer can be easily peeled from the substrate film, there are superior following properties, adhesion, and coating properties with respect to flexible and curved adherends, and there is superior compatibility with organs and the like, such as the skin and internal organs.
(e) bonding to the B surface of the thin film a functional substance identical to or different from the abovementioned functional substance and then dissolving the soluble support film with a solvent.
B32B 37/02 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by a sequence of laminating steps, e.g. by adding new layers at consecutive laminating stations
The present invention addresses the problem of providing a porous ultra-thin polymer film, and a production method for a porous ultra-thin polymer film. The present invention provides a porous ultra-thin polymer film having a film thickness of 10-1000 nm. The present invention also provides a production method for a porous ultra-thin polymer film, said method comprising: a step in which two incompatible polymers are dissolved in a first solvent at an arbitrarily-defined ratio to obtain a solution; a step in which the solution is applied to a substrate and the first solvent is eliminated from the solution applied to the substrate to obtain an ultra-thin polymer film in which the phases have separated into a sea-island structure; and a step in which the ultra-thin polymer film is immersed in a second solvent that is a good solvent for the polymer constituting the islands and a poor solvent for the polymer constituting the parts other than the islands in order to remove the islands and thereby obtain a porous ultra-thin polymer film.
C08J 9/26 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
B29C 41/12 - Spreading-out the material on a substrate
B32B 5/18 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by features of a layer containing foamed or specifically porous material
C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof
C08J 9/30 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by mixing gases into liquid compositions or plastisols, e.g. frothing with air
B29K 105/04 - Condition, form or state of moulded material cellular or porous
The present invention provides a thin film and a thin film cosmetic having excellent manageability, an excellent moisture-retaining effect, and an excellent imperfection-correcting effect. The thin film of the present invention is characterized in being a laminate of (a) a base film for supporting hyaluronic acid or a derivative thereof and (b) a carrier, wherein the thickness of film (a) is between 10 and 500 nm.
B32B 9/04 - Layered products essentially comprising a particular substance not covered by groups comprising such substance as the main or only constituent of a layer, next to another layer of a specific substance
The present invention provides a pharmaceutical preparation which comprises an alternating layer thin film, which is produced by laminating a polycation and a polyanion in an alternating manner, and a medicinal substance carried on the alternating layer thin film. As a result, it is possible to provide a pharmaceutical preparation such that the medicinal effects of a single dose have an extended duration.
A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
The present invention provides pH-responsive liposomes which are capable of holding a desired substance in an acidic pH environment and releasing the desired substance in a basic pH environment.
The present invention uses pH-responsive liposomes comprising, as constituent lipids thereof, a cationic amphiphilic molecule and at least one of an anionic amphiphilic molecule and a twitterionic amphiphilic molecule, wherein the liposomes, when dispersed in an aqueous medium, have a positive zeta potential in an acidic environment where the dispersion has a pH of less than 6.5 and have a negative zeta potential in a basic environment where the dispersion has a pH of 8.5 or more.
A method for preparing a thin film polymer structure having a functional substance on an A surface and a B surface of the film, the polymer structure being obtained by: (a) adsorbing polyfunctional molecules to a region of an arbitrary shape in an interface between a substrate body and a liquid phase; (b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; (c) bonding a functional substance to the A surface of the formed thin film and then forming a soluble support film on the A surface; (d) exfoliating the thin film and the soluble support film from the substrate body; and (e) bonding to the B surface of the thin film a functional substance identical to or different from the functional substance bonded to the A surface and then dissolving the soluble support film with a solvent.
B32B 37/02 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by a sequence of laminating steps, e.g. by adding new layers at consecutive laminating stations
patents
