Abstract

An ophthalmic cyclosporine nano-micelle drug, a preparation method therefor, and use thereof. The cyclosporine nano-micelle drug comprises: 0.1-10 parts by weight of a solubilizer for forming micelle particles, and 0.01-1 part by weight of cyclosporine loaded in the micelle particles. The solubilizer is a first solubilizer, or a combination of the first solubilizer and a second solubilizer.

IPC Classes  ?

• A61K 9/107 - Emulsions
• A61K 9/08 - Solutions
• A61K 38/13 - Cyclosporins
• A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• A61P 27/02 - Ophthalmic agents
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

23233 crystals, thereby realizing highly sensitive and nondestructive detection of atomic-scale defects in materials.

IPC Classes  ?

• G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solidsPreparation of samples therefor
• G01N 21/49 - Scattering, i.e. diffuse reflection within a body or fluid
• G01N 21/84 - Systems specially adapted for particular applications
• G01Q 60/06 - SNOM [Scanning Near-field Optical Microscopy] combined with AFM [Atomic Force Microscopy]

Abstract

Provided is a method for compensating for loss in wave propagation, comprising: obtaining real frequency responses on the basis of a measurement result of wave propagation; selecting a complex frequency on the basis of the frequency of a wave and the dielectric constant of a medium so as to at least partially counteract the imaginary part of an in-plane wave vector in the wave propagation; and on the basis of a plurality of real frequency responses and the complex frequency, obtaining a complex frequency response to compensate for loss in the wave propagation.

IPC Classes  ?

• H04B 11/00 - Transmission systems employing ultrasonic, sonic or infrasonic waves

Abstract

A method for enhancing characteristic signals by synthesizing multiple frequency waves is provided, which includes: obtaining real frequency responses based on the measurement results of spectral signals; selecting complex frequencies to at least partially compensate for spectral line broadening caused by losses; and obtaining complex frequency responses based on multiple real frequency responses and the selected complex frequencies to enhance the characteristic signals.

IPC Classes  ?

• H03L 7/16 - Indirect frequency synthesis, i.e. generating a desired one of a number of predetermined frequencies using a frequency- or phase-locked loop

Abstract

A magnetic reluctance device, a manufacturing method therefor and a use thereof. The magnetic reluctance device comprises a substrate, a multi-walled carbon nanotube film and a metal electrode, wherein the multi-walled carbon nanotube film is bonded to the surface of the substrate, and the multi-walled carbon nanotube film comprises a plurality of multi-walled carbon nanotubes distributed in parallel; the metal electrode is bonded onto the multi-walled carbon nanotube film; and an opening is formed in the joint of the multi-walled carbon nanotube film and the metal electrode. The partially opened multi-walled carbon nanotubes are in contact with electrode metal, the spin-orbit coupling effect at the interface is stronger, and the partially opened multi-walled carbon nanotubes can produce a carbon source in contact with the metal electrode, facilitating achieving the carbon-based ferromagnetic property, and expanding the use of the multi-walled carbon nanotubes in the magnetic reluctance device.

IPC Classes  ?

• H10N 50/10 - Magnetoresistive devices
• H10N 50/20 - Spin-polarised current-controlled devices
• B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
• H10K 10/46 - Field-effect transistors, e.g. organic thin-film transistors [OTFT]

Abstract

The invention provides a plasmon enhanced infrared spectrum sensor for detecting a protein secondary structure in an aqueous solution and a preparation method of the plasmon enhanced infrared spectrum sensor, and belongs to the technical field of infrared optical sensing. The sensor includes a graphene plasmon chip and a micro-fluidic system compatible with infrared transmission testing. Under excitation of incident infrared light, a locally enhanced electromagnetic field (surface plasmon) is formed on the surface of the graphene layer due to collective oscillation of charges, and molecules to be detected in an aqueous solution are enriched in a surface plasmon region due to Van der Waals interaction of the graphene layer. The infrared response of to-be-detected molecules gathered in the plasmon region is enhanced under the driving of an electromagnetic field of graphene plasmon; meanwhile, water molecules are excluded out of a plasmon region, molecular signals out of the plasmon region can be completely eliminated by using an in-situ electrical background deduction method, and direct and in-situ monitoring of trace solution components by infrared spectroscopy is realized.

IPC Classes  ?

• G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
• G01N 21/85 - Investigating moving fluids or granular solids

Abstract

Disclosed in the present invention are a subunit vaccine based on a DNA origami structure, a preparation method for the subunit vaccine, a pharmaceutical composition containing the subunit vaccine, and a use of the subunit vaccine in the preparation of a drug for preventing or treating pathogen infection.

IPC Classes  ?

• A61K 39/12 - Viral antigens
• A61K 39/385 - Haptens or antigens, bound to carriers

Abstract

Provided are a pharmaceutical composition, a radiosensitizer, an immunopotentiator, or an immunostimulant comprising a metal body, and a use thereof in immunoregulation and tumor treatment. The metal body comprises a metal nanoparticle and a bacterial component attached thereto.

IPC Classes  ?

• A61K 47/46 - Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
• A61K 35/74 - Bacteria
• A61P 35/00 - Antineoplastic agents

Abstract

Provided is a pharmaceutical composition comprising a metal oxide nanoparticle and a soluble dietary fiber, wherein the metal oxide nanoparticle is selected from one or more of a tungsten trioxide nanoparticle, a titanium dioxide nanoparticle, a manganese dioxide nanoparticle and a molybdenum oxide nanoparticle. Further provided is the use of the pharmaceutical composition in the preparation of a drug for treating tumors. The provided pharmaceutical composition has a significant inhibitory effect on tumors, and slows down an increase rate of tumor volume, and/or reduces the tumor volume and weight. In addition, the pharmaceutical composition in combination with a tumor vaccine and an immune checkpoint inhibitor can further enhance the tumor inhibitory effect. The provided pharmaceutical composition has the advantages of readily available raw materials for preparation, a simple preparation method and low costs, and is suitable for large-scale production and has good application prospects.

IPC Classes  ?

• A61K 33/24 - Heavy metalsCompounds thereof
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed in the present invention are a DNA-TRAIL composite, a method for preparing same, a kit, a method for using same to treat tumors, and the use thereof in treatment of tumors. The DNA-TRAIL composite comprises a DNA origami structure and three TRAIL monomers connected to the DNA origami structure and forming a TRAIL trimer.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/525 - Tumour necrosis factor [TNF]
• A61P 35/00 - Antineoplastic agents

Abstract

Provided are a DNA nanovaccine, a preparation method therefor and the use thereof. The DNA nanovaccine comprises a DNA nanostructure, a tumor antigen polypeptide-DNA complex and an immunologic adjuvant, and the immunologic adjuvant comprises a double-stranded RNA immunologic adjuvant and/or a CpG immunologic adjuvant. In the present invention, a nanostructure is constructed, wherein the nanostructure is assembled from a DNA template, a DNA chain for assisting in folding and a capture DNA chain. By hybridizing the capture DNA chain with a functional component, the precise positioning and assembling of a tumor antigen molecule and an immunologic adjuvant molecule on the surface of the DNA self-assembled nanostructure is realized; in addition, a controllable DNA molecule “switch” is designed on one side of the tubular DNA nanostructure, which switch can respond to the acid environment of an endosome after entering an antigen-presenting cell, and open the tubular structure responsively to release the tumor antigen and the immunologic adjuvant molecule. The nanostructure has a tumor antigen-specific immunostimulatory effect and is a tumor vaccine used for the immunotherapy and prevention of various types of malignant tumors.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 37/04 - Immunostimulants

Abstract

Disclosed are a polypeptide nanoprotein ubiquitination degradation agent PROTAC molecule, and a preparation method therefor and the use thereof. The polypeptide nanoprotein ubiquitination degradation agent is a proteolysis-targeting chimera based on a ubiquitination-proteasome system, wherein the polypeptide nanoprotein ubiquitination degradation agent comprises a module molecule comprising a module molecule A and a module molecule B; the module molecule A comprises a coupling group A, a self-assembly group, and an E3 ligase recognition group; the module molecule B comprises a coupling group B, a self-assembling group, and a targeting binding group; and the coupling group A and the coupling group B are used for linking the module molecule A and the module molecule B. The polypeptide nanoprotein ubiquitination degradation agent can achieve dose-dependent degradation, can be specifically triggered in a tumor region, significantly reduces off-target toxicity, and is a protein ubiquitination degradation agent having selectivity and specificity.

IPC Classes  ?

• C07K 7/02 - Linear peptides containing at least one abnormal peptide link
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents
• C07K 1/04 - General processes for the preparation of peptides on carriers
• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to the technical field of infrared optical sensing, and provides a plasmon enhanced infrared spectrum sensor for detecting a protein secondary structure in an aqueous solution, and a preparation method therefor. The sensor of the present invention comprises a graphene plasmon chip and a micro-fluidic system compatible with an infrared transmission test. Under the excitation of incident infrared light, a locally enhanced electromagnetic field (a surface plasmon) is formed on the surface of a graphene layer due to collective oscillation of charges; and due to Van der Waals interactions of the graphene layer, molecules to be detected in an aqueous solution are enriched in a surface plasmon area. Said molecules gathered in the plasmon area have enhanced infrared response under the driving of the electromagnetic field of the graphene plasmon; in addition, water molecules are excluded from the plasmon area, and molecular signals outside the plasmon area can be completely eliminated by using an in-situ electrical background subtraction method, thereby implementing direct and in-situ monitoring of trace components of a solution by an infrared spectrum.

IPC Classes  ?

• G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
• G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation

Abstract

The invention discloses a polypeptide that specifically binding to CD123 protein, a polypeptide complex and a co-delivery system, and preparation methods and use thereof. The general formula of amino acid arrangement in the polypeptide is X1-DYDTR-X2-QGTD-X3-G-X4-DFRRISD-X5; it can bind to CD123-positive cells and inhibit the progression of leukemia; the polypeptide complex can increase the binding quantity of the polypeptide to CD123-positive cells, and drug can inhibit the progression of leukemia alone and prolong the survival of leukemia mice; the co-delivery system can load chemotherapy drugs for tumor treatment and reduce the toxicity of chemotherapy drugs to normal cells.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 35/02 - Antineoplastic agents specific for leukemia
• A61K 31/475 - QuinolinesIsoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate

Abstract

A nano vaccine used for delivering an mRNA antigen and derived from a bacterial outermembrane vesicle and the use thereof. Specifically provided is a technology for displaying nucleic acid on the outer surface of a vesicle.

IPC Classes  ?

• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• C07K 17/00 - Carrier-bound or immobilised peptidesPreparation thereof

Abstract

An engineered cell that is capable of secreting one or more vesicle comprising one or more protein or immunogenic fragment thereof when said cell is induced and application thereof.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C12N 15/03 - Bacteria
• A61K 39/095 - Neisseria
• A61P 31/04 - Antibacterial agents

Abstract

A graphene molybdenum oxide heterojunction polariton wavefront regulation and control device and method, comprising a graphene covering layer (106), a molybdenum oxide thin layer (102), and substrate layers (100, 101) which are sequentially arranged from top to bottom. A metal antenna (103) is arranged on the graphene cover layer (106). The carrier concentration of graphene is dynamically regulated and controlled by means of chemical doping or an electrical grid voltage, thereby realizing dynamic regulation and control and topological transformation of the wavefront shape of a hyperbolic phonon polariton and plasmon hybrid mode excited in a heterostructure. The wavefront shape of a graphene molybdenum oxide heterojunction hybrid exciton is dynamically regulated and controlled by means of changing the carrier concentration, the method is simple and easy to implement, and the regulation and control means are flexible and accurate.

IPC Classes  ?

• G02B 5/00 - Optical elements other than lenses

Abstract

A carbon nanomaterial functionalized needle tip is modified with a low work function material. The needle tip is formed by combining a carbon nanomaterial with a material of a needle tip through a covalent bond. The interior or outer surface of the carbon nanomaterial is modified with a low work function material. The material of the needle tip is a metal which can be any of tungsten, iron, cobalt, nickel, and titanium. The carbon nanomaterial can be carbon nanocone or carbon nanotube. The tip of the carbon nanomaterial has the same orientation as the metal needle tip. The low work function material can be selected from metals, metal carbides, metal oxides, borides, nitrides, and endohedral metallofullerene. The carbon nanomaterial functionalized needle tip has a lower electron emission barrier, and can effectively reduce the electric field intensity required for electron emission, and improve the emission current and emission efficiency.

IPC Classes  ?

• G01R 1/067 - Measuring probes
• B81B 1/00 - Devices without movable or flexible elements, e.g. microcapillary devices
• G01Q 70/12 - Nanotube tips
• H01J 1/304 - Field-emissive cathodes

Abstract

Disclosed in the present invention are a polypeptide and a polypeptide composition specifically binding to a SARS-CoV-2 spike protein, and preparation methods therefor and the uses thereof. By means of binding to an S1 protein, the polypeptide and the polypeptide composition can block the binding of SARS-CoV-2 virus to a key target protein angiotensin-converting enzyme 2 (ACE2) protein on the surface of a host cell thereof, thereby providing a feasible targeting drug for the treatment of novel coronavirus pneumonia.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61P 31/14 - Antivirals for RNA viruses
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof

Abstract

Some embodiments of the present disclosure relate to a manufacturing method using nano-imprint lithography for a diffraction grating waveguide of a near-eye display. The manufacturing method includes: manufacturing an imprint lithography template with a diffraction grating waveguide pattern; transferring the diffraction grating waveguide pattern of the imprint lithography template to a transferring template by nano-imprint lithography, so as to obtain a transferring template with a reverse pattern of the diffraction grating waveguide pattern; and transferring the reverse pattern of the diffraction grating waveguide pattern of the transferring template to a waveguide substrate by nano-imprint lithography, so as to obtain the diffraction grating waveguide of the near-eye display.

IPC Classes  ?

• G02B 5/18 - Diffracting gratings
• B29C 33/38 - Moulds or coresDetails thereof or accessories therefor characterised by the material or the manufacturing process
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor

Abstract

A planar lens focusing device comprises a base layer (101, 201). A molybdenum oxide thin layer (102, 202) is arranged on the upper side of the base layer (101, 201). A silicon substrate (204) is arranged on the lower side of the base layer (101, 201). A metal antenna (103, 203) covers the upper side of the molybdenum oxide thin layer (102, 202), or the metal antenna (103, 203) is embedded between the lower side of the molybdenum oxide thin layer (102, 202) and the base layer (101, 201), and a graphene layer (205) covers an upper layer of the molybdenum oxide thin layer (102, 202). The graphene layer (205) and the silicon substrate (204) are connected to a voltage. The metal antenna (103, 203) excites hyperbolic phonon excimers. The Fermi level of the graphene layer (205) is changed by means of the voltage to adjust the focal length for nanofocusing. The voltage is connected between the graphene layer (205) and the silicon substrate (204), and the Fermi level of the graphene layer (205) is changed by means of changing the voltage, and the position of the focal length is dynamically adjusted to then adjust the focal length with which the planar lens focuses. The device is simple and easy to use, has a wide range of use, and is low cost.

IPC Classes  ?

• G02B 3/00 - Simple or compound lenses
• G02F 1/29 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the position or the direction of light beams, i.e. deflection
• G02F 1/33 - Acousto-optical deflection devices

Abstract

123455. The development of leukemia can be inhibited by combining with CD123 positive cells. The polypeptide complex can increase the number of polypeptides bound to the CD123 positive cells. A single drug can inhibit the development of leukemia and prolong the lifetime of the leukemia mice. The co-delivery system can load chemotherapy drugs for tumor treatment, thereby reducing the toxicity of the chemotherapeutic drugs to normal cells.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61K 9/107 - Emulsions
• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/475 - QuinolinesIsoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

A tumor vaccine, a preparation method therefor and use thereof. In particular, the present invention relates to a pharmaceutical combination comprising a first membrane component comprising a membrane derived from the inner membrane of bacteria, the pharmaceutical combination further comprising components derived from other organisms than the bacteria, a preparation method for and use of the pharmaceutical combination.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 9/51 - Nanocapsules
• A61K 47/46 - Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
• A61P 35/00 - Antineoplastic agents

Abstract

Provided in the present invention is a targeting-specific polypeptide. The amino acid sequence is composed of 30-40, preferably 33-36 amino acids; and the amino acid sequence of the C-terminus is GRKKRRQRRR and the N-terminus is labeled with biotin. Further provided in the present invention is the use of the polypeptide in the preparation of a drug for inhibiting the activity of tumor cells. The polypeptide provided by the present invention is a polypeptide that interacts with tumor cells highly expressing an EZH2 protein and can reduce the expression level of the EZH2 protein, thereby inducing the death of the tumor cells. The polypeptide provided by the present invention can be used as a potential drug for cell screening, and targeted therapy or adjuvant therapy of tumors.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61P 35/00 - Antineoplastic agents

Abstract

Provided are a DNA nanovaccine, a preparation method therefor and the use thereof. The DNA nanovaccine comprises a DNA nanostructure, a tumor antigen polypeptide-DNA complex and an immunologic adjuvant, and the immunologic adjuvant comprises a double-stranded RNA immunologic adjuvant and/or a CpG immunologic adjuvant. In the present invention, a nanostructure is constructed, wherein the nanostructure is assembled from a DNA template, a DNA chain for assisting in folding and a capture DNA chain. By hybridizing the capture DNA chain with a functional component, the precise positioning and assembling of a tumor antigen molecule and an immunologic adjuvant molecule on the surface of the DNA self-assembled nanostructure is realized; in addition, a controllable DNA molecule "switch" is designed on one side of the tubular DNA nanostructure, which switch can respond to the acid environment of an endosome after entering an antigen-presenting cell, and open the tubular structure responsively to release the tumor antigen and the immunologic adjuvant molecule. The nanostructure has a tumor antigen-specific immunostimulatory effect and is a tumor vaccine used for the immunotherapy and prevention of various types of malignant tumors.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61P 35/00 - Antineoplastic agents
• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

Abstract

A nanoparticle having the cGAS-STING activation function. The nanoparticle is an organic-inorganic hybrid nanoparticle containing a metal ion. The metal ion has the cGAS-STING activation function. The nanoparticle comprises a macromolecule and the metal ion, and is formed by the interaction of the macromolecule with the metal ion and a negative ion. Moreover, the macromolecule can protect the colloidal stability of the nanoparticle. The nanoparticle can effectively trigger the production of STING-dependent type I interferon, and can be administered to a subject using different routes (comprising intravenous therapy, intramuscular injection, intradermal injection, intranasal injection, etc.). A nanoparticle preparation can be used for treating disorders and diseases that are beneficial in regulating STING activity, such as infectious diseases, cancer, inflammation, allergic and autoimmune diseases, and precancerous syndromes. The nanoparticle can also be used for triggering the immune response, and can be used as a vaccine adjuvant.

IPC Classes  ?

• A61K 33/32 - ManganeseCompounds thereof
• A61K 33/30 - ZincCompounds thereof
• A61K 9/14 - Particulate form, e.g. powders

Abstract

Provided are a preparation method for a hypoxic-region-targeting short-chain polypeptide micromolecule self-assembly nanometer material, and the use thereof. The nanometer material is a micromolecule carbonic anhydrase inhibitor modified by a short-chain polypeptide, wherein the N terminus of the short-chain polypeptide is bound to a substituted or unsubstituted aromatic group. By means of targeting carbonic anhydrase, which is highly expressed on a hypoxic tumor cell membrane, tumor micro-environment in-situ responsive self-assembly is realized, and specific endocytosis of the hypoxic tumor cells is induced, so that hypoxic tumor cells are regulated, controlled, killed and damaged. The material is simple in terms of preparation process, has higher biological safety, can effectively kill and damage the hypoxic tumor cells, can significantly improve conventional clinical chemotherapy treatment effects, can retard the tumor metastasis process and can provide more thinking and means for clinical tumor treatment.

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
• A61P 35/00 - Antineoplastic agents

Abstract

A method for using nano-imprint technology to prepare a diffraction grating waveguide of a near-eye display, pertaining to the technical field of near-eye display, and resolving the issue of the prior art in which preparation of diffraction grating waveguides is difficult and low-yielding, has poor repeatability, and cannot be performed on a large scale. The preparation method comprises the following steps: preparing an imprint template having a diffraction grating waveguide pattern; transferring the diffraction grating waveguide pattern of the imprint template to a transfer template by means of a nano-imprint process so as to obtain a transfer template having a mirrored pattern of the diffraction grating waveguide pattern; and transferring the mirrored pattern of the diffraction grating waveguide pattern of the transfer template to a waveguide substrate by means of the nano-imprint process so as to obtain a diffraction grating waveguide of a near-eye display. The preparation method can be applied to the preparation of a diffraction grating waveguide of a near-eye display.

IPC Classes  ?

• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02B 6/13 - Integrated optical circuits characterised by the manufacturing method
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor

Abstract

A graphene-based conductive structure having a self-repairing function, a manufacturing method for the same, and a self-repairing method for a graphene-based conductive structure having a self-repairing function. The graphene-based conductive structure having a self-repairing function comprises graphene nanosheets and nanocellulose. The graphene-based conductive structure having a self-repairing function has both high mechanical strength and superior electrical conductivity, is capable of restoring its shape and electrical conductivity in an aqueous environment after breakage, has high flexibility, and is widely applicable in fields such as high-performance fibers, biosensors, composite fiber materials, and adsorbent materials.

IPC Classes  ?

• C08L 1/04 - OxycelluloseHydrocellulose
• C08K 3/04 - Carbon
• C08B 15/02 - OxycelluloseHydrocelluloseCellulose hydrate
• H01B 1/24 - Conductive material dispersed in non-conductive organic material the conductive material comprising carbon-silicon compounds, carbon, or silicon

Abstract

Provided in the present invention are a high-throughput microfluidic chip, and a preparation method and the use thereof. The microfluidic chip comprises: a nerve cell chamber located in the center and cancer cell chambers located around the nerve cell chamber, and the nerve cell chamber and the cancer cell chambers are connected therebetween by microchannels. The microfluidic chip in the present invention can realize the precise control of neurite growth, and the design of different chambers can realize the co-culturing of nerves and cancer cells. In addition, this microfluidic chip has the characteristics of a high throughput, and the unique image analysis algorithm used by the present invention can evaluate the morphology of mutual recognition between the cancer cell and the neurite during the migration process of cancer cells.

IPC Classes  ?

• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms

Abstract

A humidity sensor (1) and a manufacturing method therefor, and an electronic device comprising the humidity sensor (1). The humidity sensor (1) comprises: a nano-paper substrate (100) that expands to different extents under different humidity environments; a sensing element (200) located on the surface of the nano-paper substrate (100), and having electric properties changing in response to the expansion of the nano-paper substrate (100); and an electrode (300) electrically connected to the sensing element (200). The humidity sensor (1) is of great significance to the development of a wearable and environmentally-friendly electronic device.

IPC Classes  ?

• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid

Abstract

The present disclosure generally relates to pressure detection technology, and in particular, to a pressure sensor, a method of fabricating a pressure sensor, and a pressure detecting device. The pressure sensor may include a flexible nanopaper, and a graphene film on one side of the flexible nanopaper.

IPC Classes  ?

• G01L 1/22 - Measuring force or stress, in general by measuring variations in ohmic resistance of solid materials or of electrically-conductive fluidsMeasuring force or stress, in general by making use of electrokinetic cells, i.e. liquid-containing cells wherein an electrical potential is produced or varied upon the application of stress using resistance strain gauges

Abstract

The invention relates to a micro-nano particles detection system and a method thereof. The system comprises a heating unit (1), a sample chamber unit (2), and a signal acquisition unit (4), wherein the heating unit (1) is arranged outside the sample chamber unit (2) for heating a sample in the sample chamber unit (2). Micro-nano particle fluid is loaded in the sample chamber unit (2). After the heating unit (1) heats the sample chamber unit (2), the sample chamber unit (2) generates a thermophoresis effect, so that the micro-nano particles are gathered at one side with temperature lower than the micro-nano particle fluid in the sample chamber unit (2). The signal acquisition unit (4) is used for collecting relevant information of the gathered micro-nano particles, and carrying out corresponding analysis. The micro-nano detection system performs accumulation on the particles by the thermophoresis effect, and the gathering and detection can be completed only with insignificant amounts of micro nano particles, without need of sample pre-treatment and purification of the micro nano particles. The micro-nano particles detection system is generally used for an aptamer and an antibody, and has wide application prospect.

IPC Classes  ?

• G01N 1/44 - Sample treatment involving radiation, e.g. heat
• G01N 21/64 - FluorescencePhosphorescence

Abstract

A nanopaper, a preparation method therefor and a flexible electronic device. The nanopaper is prepared by nanocellulose of which the surface is adsorbed with polysaccharide, and the diameter of the nanocellulose is less than 100 nm. The preparation method for the nanopaper comprises: soaking the nanocellulose in a polysaccharide-containing solution to obtain treated nanocellulose; and preparing the nanopaper by utilizing the treated nanocellulose. The nanopaper can be applied to the flexible electronic device.

IPC Classes  ?

• D21H 11/00 - Pulp or paper, comprising cellulose or lignocellulose fibres of natural origin only
• D21H 17/28 - Starch
• D21H 17/25 - Cellulose
• D21H 17/24 - Polysaccharides

Abstract

Provided is a DNA nanostructure nanorobot comprising: a single stranded DNA scaffold strand of about 5,000 to 10,000 bases in length; a plurality of staple strands of DNA, wherein each staple strands are about 20 to 40 bases in length, wherein each staple strand has a unique sequence and is hybridized to a specific position on the DNA scaffold strand, wherein the plurality of staple strands hybridized to the DNA scaffold form a sheet having a top surface and a bottom surface; and one or more fastener strands of DNA, wherein the one or more fastener strands of DNA are capable of fastening the sheet into an origami structure.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

Provided is a conical nano-carbon material functionalized needle tip, formed by assembling a nano-carbon material with a material of a needle tip by means of a covalent bond; and the material of the needle tip is a metal selected from one or more of tungsten, iron, cobalt, nickel and titanium. Further provided is a method for preparing the conical nano-carbon material functionalized needle tip. The conical nano-material functionalized needle tip has an outstanding interface formed by metal-carbide covalent bonds, and the orientation of the conical nano-material is matched with the axial direction of the metal needle tip (illustrated in FIG. 6). The proposed preparation method affords a robust interface and avoids the potential pollution to the nano-material caused during the deposition of fixing materials, such as carbon or platinum or the like, in other preparation methods.

IPC Classes  ?

• G01R 1/067 - Measuring probes
• B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
• B81B 1/00 - Devices without movable or flexible elements, e.g. microcapillary devices
• G01Q 70/10 - Shape or taper
• G01Q 70/18 - Functionalisation
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• G01Q 30/02 - Non-SPM analysing devices, e.g. SEM [Scanning Electron Microscope], spectrometer or optical microscope
• G01Q 70/12 - Nanotube tips
• G01R 3/00 - Apparatus or processes specially adapted for the manufacture of measuring instruments

Abstract

The present invention provides a surface modification method for a flexible stretchable line, and use thereof. Said method can significantly improve the cytocompatibility and histocompatibility of a conductive line and the line stability of the conductive line directly contacting the cell/tissue, and the conductivity performance can still be well maintained after a long-time cell co-culture or implantation in vivo; the Faraday cage effect caused by a surface oxide layer is overcome, and the formed electrode can generate a stable electric field, improving the functionality of the conductive line; said method has simple steps and is easy to operate, can perform surface treatment without a special instrument, and is used for large-scale preparation of a functional flexible line; a flexible stretchable line subjected to direct surface modification or multiple surface modifications can be widely used in conductive lines which are in direct contact or indirect contact with cells or tissues, and can be used in the fields of tissue engineering, biosensing, photoelectric materials, etc. Said method can quickly realize large-scale industrial preparation, and can be used in the fields of wearable electronic devices, implanted medical instruments, etc.

IPC Classes  ?

• H05K 3/10 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern

Abstract

Provided are a gel fiber composite scaffold material formed through one step and a preparation method and a use thereof. The preparation method of the composite scaffold material comprises steps as follows: preparing an electrospun film through a high-voltage electrostatic method; and soaking the electrospun film into a phase separation solution to obtain the gel fiber composite scaffold material. The obtained composite scaffold material is an extracellular matrix simulated composite material and can be modified by adding multiple natural biomaterials, so that the composite material is closer to an extracellular matrix in terms of components.

IPC Classes  ?

• A61L 27/26 - Mixtures of macromolecular materials
• A61L 27/20 - Polysaccharides
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
• D06M 13/322 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials with non-macromolecular organic compoundsSuch treatment combined with mechanical treatment with compounds containing nitrogen

Abstract

Provided are a fluorescent gold nanocluster with a surface modified by an oligoarginine and a preparation method for the fluorescent gold nanocluster. Also provided are a fluorescent gold nanocluster-based method for reactive oxygen species detection, a reagent kit comprising the fluorescent gold nanocluster, and an application of the fluorescent nanocluster and a combination product thereof. The fluorescent gold nanocluster has strong anti-photobleaching and anti-flickering properties and a good biocompatibility. The method for reactive oxygen species detection is easy to use and is characterized by mild reaction conditions including ambient temperature and pressure, an aqueous phase, and a near-neutral pH, thereby enhancing an application of the fluorescent gold nanocluster in the field of biology.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• B82Y 40/00 - Manufacture or treatment of nanostructures
• A61K 33/24 - Heavy metalsCompounds thereof

Abstract

Disclosed is a gold nanoparticle which is modified on its surface by a nitrogen heterocyclic small molecule that is preferably one or more molecules selected from a triazole with a mercapto, imidazole with a mercapto, purine with a mercapto and benzothiazole with a mercapto. The gold nanoparticle prepared exhibits good antibacterial properties against gram-negative bacteria, gram-positive bacteria and/or clinical bacteria isolates with multidrug resistance, and may have good biocompatibility. Also provided are a method for preparing the gold nanoparticle, an antibacterial composition and a kit comprising the gold nanoparticle, and a use of the gold nanoparticle and the antibacterial composition in the preparation of antibacterial products or medicines.

IPC Classes  ?

• C09K 11/58 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing copper, silver or gold
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed are a combination of NGF siRNAs with gold nanoclusters and a preparation method therefor, a pharmaceutical composition and a kit comprising the combination of NGF siRNAs with gold nanoclusters, and the use of the combination of NGF siRNAs with gold nanoclusters in the preparation of drugs for preventing and/or treating cancers. The combination of NGF siRNAs with gold nanoclusters comprises gold nanoclusters and NGF siRNAs, and the gold nanoclusters are combined with the NGF siRNAs via electrostatic adsorption.

IPC Classes  ?

• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 33/24 - Heavy metalsCompounds thereof
• A61P 35/00 - Antineoplastic agents
• A61K 9/14 - Particulate form, e.g. powders

Abstract

Provided is a tapered nano-carbon material functionalized needle tip, formed by combining a nano-carbon material with a material of a needle tip by means of a covalent bond; and the material of the needle tip is a metal selected from one or more of tungsten, iron, cobalt, nickel and titanium. Further provided is a method for preparing the tapered nano-carbon material functionalized needle tip. The tapered nano-material functionalized needle tip has a good interface touch, and the orientation of the tapered nano-material is matched with the axial direction of the metal needle tip. The proposed preparation method avoids the potential pollution to the nano-material caused during the deposition of fixing materials, such as carbon or tungsten or the like, in other preparation methods.

IPC Classes  ?

• B81B 1/00 - Devices without movable or flexible elements, e.g. microcapillary devices
• B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

Disclosed in the invention are a ceramic silicone rubber, a preparation method and use thereof. As to the ceramic silicone rubber, the silicone rubber system is added with fillers such as a highly effective flame retardant catalyst, inorganic mineral powders, a nanosized metal oxide and/or metal hydroxide, and lamellar nanosized powders, and when being heated, a silicone rubber forms, in a wide range of temperature, a rigid ceramic body with the fillers therein in the presence of a catalyst. The ceramic silicone rubber has halogen-free, smoke-free characteristics upon burning and has excellent fire prevention, flame retardant, mechanical, electrical insulating and processing performances. This can be used in the fields of cable materials, sealing rings, silicone rubber coatings, ablation resistant materials, and fire clay and the like.

IPC Classes  ?

• C08L 83/07 - Polysiloxanes containing silicon bound to unsaturated aliphatic groups
• C08K 13/02 - Organic and inorganic ingredients
• C08K 3/22 - OxidesHydroxides of metals
• C08K 3/36 - Silica
• H01B 3/28 - Insulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances natural or synthetic rubbers
• H01B 7/295 - Protection against damage caused by external factors, e.g. sheaths or armouring by extremes of temperature or by flame using material resistant to flame

Abstract

Provided are a CRISPR-Cas9 system, and preparation method and use thereof. The system comprises sgRNAs at specific gene loci on a specific target HIV genome, and the specific gene loci on the HIV genome comprise one or more of Gag, Env, Pol, Tat, Nef, Vif, Vpr, Vpu, 5'LTR, 3'LTR and Rev.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/55 - Hydrolases (3)
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• A61P 31/18 - Antivirals for RNA viruses for HIV
• A61K 38/46 - Hydrolases (3)
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

The present invention provides a preparation method of an antigen composition. The preparation method comprises the following steps: (1) obtaining a tumor antigen protein; (2) making the tumor antigen protein into contact with an immature dendritic cell; (3) inducing the immature dendritic cell in contact with the tumor antigen into a mature dendritic cell; and (4) separating a cell vesicle of the mature dendritic cell. The present invention further provides an antigen composition obtained through the preparation method and the application thereof in preparing a tumor vaccine.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C12N 5/0784 - Dendritic cellsProgenitors thereof

Abstract

An SPR sensor is provided, comprising: a substrate (11), which is made of transparent inorganic material; an adhesion layer (12) formed on the substrate (11), which is made of Cr or Ti; an adhesion enhancing layer (13) formed on the adhesion layer (12), which is made of Au or Au containing alloy; a metal functional layer (14) formed on the adhesion enhancing layer (13), which is made of Ag. By inserting the adhesion enhancing layer (13) made of Au or Au containing alloy between the Cr or Ti adhesion layer (12) and the Ag metal functional layer (14), the metal functional layer (14) made of Ag is firmly adhered to the transparent inorganic substrate (11) to ensure the long term stability of the performance of the SPR sensor.

IPC Classes  ?

• G01N 21/41 - RefractivityPhase-affecting properties, e.g. optical path length
• G01N 21/55 - Specular reflectivity

Abstract

Provided is a method for treating single wall carbon nanotubes, comprising: (1) with the presence of solvent, contacting single wall carbon nanotubes with surface active agent and then dispersant in sequence, so that the amount of single dispersed carbon nanotubes is no less than 50 wt%, said single wall carbon nanotubes can be dispersed in the solvent and said surface active agent and dispersant can be dissolved in the solvent; (2) conducting density gradient centrifugation on the dispersed single wall carbon nanotubes obtained from step (1). This method can effectively separate single wall carbon nanotubes with different structures.

IPC Classes  ?

• C01B 31/02 - Preparation of carbon; Purification

Abstract

A detection method of nucleic acid is provided. The method includes: providing nucleic acid to be tested, making the nucleic acid to be tested react under asymmetric PCR conditions with a pair of primers for target nucleic acid amplification, DNA polymerase, adenine deoxyribonucleotide, guanine deoxyribonucleotide, cytosine deoxyribonucleotide and thymidine deoxyribonucleotide in a PCR buffer solution, mixing the reaction product and liquid that contains probe molecules, and judging whether the nucleic acid to be tested contains the target nucleic acid by observing the obtained mixture color or color change. A kit is also provided that can be used in the nucleic acid detection by the said method. Application of the method and the kit in inspection and quarantine is also provided. The method is a quick and easy, sensitive and a specific detection method of nucleic acid with direct observation using naked eyes. The method does not need additional equipment.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The present invention provides a preparation method of an antigen composition. The preparation method comprises the following steps: (1) obtaining a tumor antigen protein; (2) making the tumor antigen protein into contact with an immature dendritic cell; (3) inducing the immature dendritic cell in contact with the tumor antigen into a mature dendritic cell; and (4) separating a cell vesicle of the mature dendritic cell. The present invention further provides an antigen composition obtained through the preparation method and the application thereof in preparing a tumor vaccine.

IPC Classes  ?

• A61K 39/385 - Haptens or antigens, bound to carriers
• A61K 35/14 - BloodArtificial blood
• A61P 35/00 - Antineoplastic agents

Abstract

A drug-loaded liposome, a method for preparing same, and an application thereof in preparing an antitumor drug. The drug-loaded liposome comprises a long cyclic liposome and active drug components enclosed therein. The long cyclic liposome is the liposome whose liposome surface is modified by phosphatidylethanolamine-polyethylene glycol 2000, and the active drug components are taxol and resveratrol. The method for preparing same comprises: making a liposome source, phosphatidylethanolamine-polyethylene glycol 2000, and active drug components into a drug-loaded liposome by adopting a film-ultrasonic method, the active drug components being taxol and resveratrol.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
• A61K 31/05 - Phenols
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed herein is a method for preparing functionalized silicon nanoparticles, including: (1) providing hydrogen-terminated silicon nanoparticles; and (2) subjecting the hydrogen-terminated silicon nanoparticles to hydrosilylation with a hydrosilylating reagent in the presence of a microwave irradiation. This method contributes several advantages such as simple work-up procedure, shorter reaction time, milder conditions and environmental friendliness.

IPC Classes  ?

• B82Y 40/00 - Manufacture or treatment of nanostructures
• B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
• B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

Abstract

A method for detecting hepcidin. Having a sample liquid in contact with a nanochip having a specific surface coating structure of silicon oxide, so that hepcidin is enriched with specificity; eluting the nanochip with an eluent; by performing mass spectrometric detection on the elution product, determining the hepcidin content in the elution product. The enrichment method substantially enhances the sensitivity and accuracy of mass spectrometric detection. A kit for detecting hepcidin comprising a sample diluent and a nanochip, the sample diluent comprising water, trifluoroacetic acid, and acetonitrile.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention provides a detection method of nucleic acid. The character of the method is that the method comprises the following steps: providing nucleic acid to be tested, in asymmetric PCR reaction conditions, making the nucleic acid to be tested react with a pair of primers that enable the target nucleic acid amplification, DNA polymerase, adenine deoxyribonucleotide, guanine deoxyribonucleotide, cytosine deoxyribonucleotide and thymidine deoxyribonucleotide in the PCR buffer solution, mixing the product of the reaction and the liquid that contains probe molecules, and judging whether the nucleic acid to be tested contains the target nucleic acid or not by observing the color or the color change of the obtained mixture. The present invention also provides a kit that can be used in the nucleic acid detection by the said method and the application of the method and the kit in inspection and quarantine. The method of the present invention is a quick and easy, sensitive and specific detection method of nucleic acid with direct observation using naked eyes, and the method does not need additional equipment.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage

Abstract

A transparent electrode material and a manufacturing method thereof are provided. The material comprises a substrate (1) and a conductive layer adhered to the substrate (1). The conductive layer comprises graphene and metal. The conductive layer has a sheet resistance of less than 1000Ω/sq, a light transmission of 70-98% in the visible region, and a light transmission of 70-98% in the infrared region. Because of having a composite structure including metal and graphene, the transparent electrode has excellent performances of high transmittance and low resistance. Adding graphene can enhance structural stability and bending resistance of the transparent electrode, further increase electron transport channels, and finally improve the electrical conductivity of the transparent electrode. The transparent electrode material is widely used in optoelectronic devices, photodetectors and semiconductor luminescence, especially in flexible devices such as flexible solar cells, flexible display devices. The manufacturing method is simple, and the industrial production is easily achieved.

IPC Classes  ?

• H01B 5/14 - Non-insulated conductors or conductive bodies characterised by their form comprising conductive layers or films on insulating-supports
• H01B 13/00 - Apparatus or processes specially adapted for manufacturing conductors or cables

Abstract

A visual detection method for antigen/antibody reaction is provided. The method includes: adding antibodies labeled by copper oxide nanoparticles into a sample to be tested, and detecting the copper oxide nanoparticles labeling antibodies by use of alkyne-functionalized and azide-functionalized gold nanoparticles to obtain the information about the antigen/antibody reaction. The result can be obtained with naked eyes in this method. Applications of the method, a visual detection kit for antigen/antibody reaction and applications thereof are provided.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

A process for labeling antibody with copper oxide nanoparticle is provided. Especially, the process is carried out by simple physical adsorption. The process can be used in the detection and diagnosis of immune associated diseases. A kit comprising copper oxide nanoparticle and its use are also provided.

IPC Classes  ?

• G01N 33/553 - Metal or metal coated
• G01N 33/551 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
• G01N 33/531 - Production of immunochemical test materials
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
• C01G 3/02 - OxidesHydroxides

Abstract

A method for preparing a graphene based conductive material and the graphene based conductive material prepared by the method. The method includes: preparing a solid film by applying an oxidized graphene sol and a metal salt solution and/or a metal colloidal solution on a substrate layer; after separating or non-separating the solid film from the substrate layer, placing them for 30 seconds to 10000 hours in a hydrogen atmosphere or a reducing atmosphere containing hydrogen with temperature ranging from -50℃ to 200℃ and hydrogen pressure ranging from 0.01 to 100MPa; obtaining the graphene based conductive material. The preparation method can be processed at a low temperature and uses cheap hydrogen as a reductant, so the preparation process is simple and environmental friendly.

IPC Classes  ?

• C01B 31/02 - Preparation of carbon; Purification

Abstract

Gold nanoparticles modified by amino pyrimide, the preparation method and the use thereof are disclosed. Amino pyrimidine is preferably selected from 2-thiol-4,6-diamino pyrimidine, 2-thiol-4-amino pyrimidine and/or 2,4-diamino-6-mercaptopyrimidine. The particle size of gold nanoparticles is 1.5-10.0 nm and the molar ratio of amino pyrimidine to Au is 0.1:1-0.9:1. The gold nanoparticles have broad-spectrum antibiotic effect.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 47/02 - Inorganic compounds
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics