Abstract

This preparation for reducing a plant growth inhibitor contained in a target contains Rasamsonia emersonii.

IPC Classes  ?

• B09B 3/60 - Biochemical treatment, e.g. by using enzymes
• C12N 1/14 - Fungi Culture media therefor
• C12N 15/09 - Recombinant DNA-technology

Abstract

An object of the present invention is to provide a new means for suppressing inhibition of proliferation of keratinocytes even when the keratinocytes start to come into contact with each other. The present invention solves the above problem by culturing keratinocytes in contact with a common medium with fibroblasts treated with a composition containing a specific compound.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 31/7016 - Disaccharides, e.g. lactose, lactulose
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

Provided are a CAR library used to screen scFvs that can be functional in CAR-T cells, and an scFv manufacturing method in which the CAR library is used. A chimeric antigen receptor (CAR) library of the present invention includes nucleic acids coding for first CARs. Each of the first CARs includes a first antigen-binding domain, a first transmembrane domain, and a first intracellular signaling domain. The first antigen-binding domain includes a first single-chain antibody (scFv) to be screened for the ability to bind to a target antigen. The first scFv includes a first heavy-chain variable region and a first light-chain variable region. The first heavy-chain variable region and the first light-chain variable region meet a predetermined condition.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 40/42 - Cancer antigens
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 14/725 - T-cell receptors
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

The present invention addresses the problem of providing: a compound having a hepatitis C virus (HCV) inhibition activity and can prevent and/or treat hepatitis C; and a medicine containing the compound. [Solution] The present invention provides: a compound having a structure represented by formula (I) or (IV) and having an HCV inhibition activity; and a composition containing the compound.

IPC Classes  ?

• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/403 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 31/14 - Antivirals for RNA viruses
• A61P 35/00 - Antineoplastic agents
• C07D 209/30 - IndolesHydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
• C07D 209/80 - [b, c]- or [b, d]-condensed
• C07D 209/88 - CarbazolesHydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Abstract

Provided is a useful method for treating waste water that contains a heavy metal or an organic pigment as a contaminant, wherein waste water from a factory or the like is continuously and gradually supplied, via an introduction path (21), to a treatment tank (2) which has been charged with thermophilic cyanobacteria such as Thermosynechococcus elongatus, and carbon dioxide gas is ejected from a gas supply pipe (22). In a photosynthetic environment which is, for example, irradiated with solar light, the waste water from the introduction path (21) is treated by being stirred with the thermophilic cyanobacteria by the ejected carbon dioxide gas, the water level in the treatment tank (2) rises, and the waste water flows out to a precipitation tank (3) through a liquid feed pipe (31). In the waste water that has flowed out to the precipitation tank (3), thermophilic bacteria contained therein precipitates to a bottom part as sludge, and a supernatant liquid flows out through a waste water pipe (32) due to a rise in water level. When waste water containing a heavy metal is treated, a supernatant liquid from which the heavy metal has been separated flows out, and when waste water containing an organic pigment is treated, a supernatant liquid from which the pigment has been removed flows out.

IPC Classes  ?

• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used
• C12N 1/12 - Unicellular algaeCulture media therefor
• C12N 1/20 - BacteriaCulture media therefor
• C22B 3/18 - Extraction of metal compounds from ores or concentrates by wet processes with the aid of microorganisms or enzymes, e.g. bacteria or algae

Abstract

An embodiment of the present invention provides a diamond formation device comprising: a reaction vessel in which a raw material liquid containing a carbon source is held and a substrate is placed in the raw material liquid; and an electrode part capable of generating plasma in the raw material liquid, wherein the substrate has at least one recess on a main surface on a side facing the electrode part. In addition, an embodiment of the present invention also provides a diamond-coated substrate comprising: a substrate having at least one recess on a main surface; and diamond directly formed on the main surface of the substrate.

IPC Classes  ?

• C23C 16/27 - Diamond only
• C23C 16/50 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges
• H01J 37/32 - Gas-filled discharge tubes

Abstract

The present invention addresses the problem of developing a new polypeptide that has an activity of ligating an acceptor substrate having an amino group and a donor substrate having a specific amino acid sequence such as a Sortase recognition motif peptide, even while having an amino acid sequence significantly different from known-to-date Sortase A or the like.　The present invention pertains to: a polypeptide that has an activity of binding an acceptor substrate having at least one primary amine and a donor substrate having at least one donor substrate recognition sequence, and that has an amino acid sequence selected from (a)-(c): (a) an amino acid sequence at positions 1-178 of SEQ ID NO. 1; (b) an amino acid sequence having a deletion, an insertion, a substitution, or an addition of 1-35 amino acid residues with respect to the amino acid sequence at positions 1-178 of SEQ ID NO. 1; and (c) an amino acid sequence having at least 80% identity with respect to the amino acid sequence at positions 1-178 of SEQ ID NO. 1.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 9/50 - Proteinases
• C12N 15/57 - Hydrolases (3) acting on peptide bonds (3.4)
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

[Problem] The purpose of the present invention is to provide: a compound that can be suitably used in a fluorescent dye or the like; a novel fluorescent dye and a kit for conveniently detecting cells; a novel method for conveniently detecting cells; and a dyeing material or the like. [Solution] A compound represented by formula (1) or a salt thereof. (In formula (1), R1 is an alkyl group having 1-12 carbon atoms, an alkenyl group having 2-12 carbon atoms, an alkynyl group having 2-12 carbon atoms, or the like, all of the foregoing being substituted or unsubstituted.)

IPC Classes  ?

• C07C 229/18 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
• C07D 295/112 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulfur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
• C07D 295/155 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers

Abstract

The present invention aims at providing a compound that can be suitably used as a fluorescent dye or the like, a novel fluorescent dye and kit for easily detecting cells, a novel method for easily detecting cells or the like, and so on. A compound represented by the following formula (1) or a salt thereof: The present invention aims at providing a compound that can be suitably used as a fluorescent dye or the like, a novel fluorescent dye and kit for easily detecting cells, a novel method for easily detecting cells or the like, and so on. A compound represented by the following formula (1) or a salt thereof: in the formula (1), R1 is a substituted or unsubstituted alkyl group having 1 to 12 carbon atoms or the like; R2 and R3 are each independently a substituted or unsubstituted alkyl group having 1 to 6 carbon atoms or the like; R4 and R5 are each independently an alkyl group having 1 to 12 carbon atoms or the like; n is an integer of 1 to 4; and a and b are each independently an integer of 0 to 4.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• C09B 3/70 - Benzo-, naphtho-, or anthra-dianthrones

Abstract

2222222O removal that are present within the support material.

IPC Classes  ?

• C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
• A01G 24/40 - Growth substratesCulture mediaApparatus or methods therefor characterised by their structure
• C12N 11/02 - Enzymes or microbial cells immobilised on or in an organic carrier

Abstract

The present invention provides an oil synthesis device, as one embodiment thereof, which includes an electrode-holding part that is kept at ordinary temperature and ordinary pressure and that can hold inside an electrode part capable of generating a plasma in a raw-material liquid derived from both carbon dioxide and water. By the plasma, an oil can be synthesized from the raw-material liquid located inside the electrode-holding part.

IPC Classes  ?

• C07C 29/152 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of oxides of carbon exclusively with hydrogen or hydrogen-containing gases characterised by the reactor used
• C07C 31/08 - Ethanol
• C07C 45/00 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds
• C07C 49/08 - Acetone
• H05H 1/00 - Generating plasmaHandling plasma

Abstract

Provided are: a light-emitting material that is for blue light-emitting organic EL and that comprises a phosphinine derivative; and an organic EL element that contains the light-emitting material for organic EL. A light-emitting material for organic EL according to the present invention is characterized by comprising a phosphinine derivative having an electron-withdrawing group at position C4 of a six-membered ring including a phosphor atom. Furthermore, an organic EL element according to the present invention is characterized by comprising a pair of electrodes, and at least one organic light-emitting layer interposed between the pair of electrodes, and is characterized in that the at least one organic light-emitting layer contains an anthracene compound and a phosphinine derivative.

IPC Classes  ?

• H10K 85/60 - Organic compounds having low molecular weight
• C07F 9/535 - Organo-phosphoranes
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H10K 50/12 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers comprising dopants

Abstract

The present invention provides a cart that can perform bedside cleaning and carry an endoscope, and carries the endoscope, and carries an endoscope including an insertion unit to be inserted into a body cavity and an operation unit for operating the insertion unit, the cart including: a placement portion on which a storage bag storing a cleaning liquid is placed; and a holding portion that holds the operation unit above the placement portion, in which the operation unit is held by the holding portion, and the insertion unit is immersed in the cleaning liquid in the storage bag.

IPC Classes  ?

• A61B 1/12 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with cooling or rinsing arrangements
• A61B 50/20 - Holders specially adapted for surgical or diagnostic appliances or instruments
• A61B 90/70 - Cleaning devices specially adapted for surgical instruments

Abstract

Provided is a method for producing 2-O-trans-caffeoylhydroxycitric acid, the method including a step in which coriander is immersed in a polar solvent to extract 2-O-trans-caffeoylhydroxycitric acid with the polar solvent.

IPC Classes  ?

• C07C 67/56 - SeparationPurificationStabilisationUse of additives by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by chemisorption
• C07C 69/732 - Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids

Abstract

A vibration damping structure according to the present invention is provided with a first supporting member, a second supporting member, and one or more vibration damping units. The one or more vibration damping units are connected between the first supporting member and the second supporting member and suppress vibration in a first direction acting upon the first supporting member and the second supporting member. Each of the one or more vibration damping units includes a first vibration damping core unit which is connected to the first supporting member by a hinge and a second vibration damping core unit which is connected to the second supporting member by a hinge. The first and second vibration damping core units are also connected by a hinge. Each of the first and second vibration damping core units have four rotating members, and each rotating member is connected to another member by a hinge whose position when viewed from the first direction is appropriately defined. The position of the hinge is appropriately defined so as to allow rotation of the rotating members when acted upon by vibration in the first direction.

IPC Classes  ?

• F16F 15/02 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system
• G10K 11/16 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general

Abstract

An artificial knee joint 1 includes: an insert member 2 embedded in a part of a joint surface of a medial condyle MC or lateral condyle LC of a tibia T; and a bridge member 3 disposed underneath the insert member 2, and having a length that allows both ends thereof to be anchored to a cortical bone of a tibia T.

IPC Classes  ?

• A61F 2/38 - Joints for elbows or knees
• A61F 2/30 - Joints

Abstract

The present invention addresses the problem of providing a vaccine composition for nasal administration that is usable for preventing and treating hepatitis B, and a nasal administration system of the vaccine.　Provided is a hepatitis B vaccine composition that comprises: (i) virus-like particles containing hepatitis B surface L antigen proteins (HBs-L antigen proteins) of two or more genotypes selected from the group consisting of types A, B, C and D, and a hepatitis B nucleocapsid antigen (HBc antigen) protein; and (ii) a base material containing a carboxyvinyl polymer having been treated by externally applying a shear force. Also provided is a nasal administration system of the hepatitis B vaccine, said system comprising the composition filled into a sprayable device equipped with a nasal spray nozzle.

IPC Classes  ?

• A61K 39/29 - Hepatitis virus
• A61K 9/12 - AerosolsFoams
• A61K 39/295 - Polyvalent viral antigensMixtures of viral and bacterial antigens
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61M 11/00 - Sprayers or atomisers specially adapted for therapeutic purposes
• A61P 31/20 - Antivirals for DNA viruses
• C07K 14/02 - Hepadnaviridae, e.g. hepatitis B virus
• C07K 19/00 - Hybrid peptides
• C12N 7/01 - Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material

Abstract

The present invention relates to providing a novel method for easily detecting tumor cells in a tissue derived from an organism. The present invention includes a fluorescent dye for detecting tumor cells in a tissue, including a compound that exhibits solvatochromism. The present invention also includes a method for detecting tumor cells or specifying a tumor removal area, including applying the fluorescent dye to staining of a tissue derived from an organism and to an organism.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C09B 57/00 - Other synthetic dyes of known constitution
• G01N 1/30 - StainingImpregnating

Abstract

The present disclosure includes a monoclonal antibody or antibody fragment that binds to an epitope consisting of 5 to 20 consecutive amino acids in the amino acid sequence of SEQ ID NO: 1, and a method of detecting or quantifying an Ripr-derived malaria vaccine antigen comprising contacting a sample with the monoclonal antibody or antibody fragment.

IPC Classes  ?

• C07K 16/20 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• A61P 37/04 - Immunostimulants

Abstract

[Problem] To identify the angle of a joint in a subject while more reducing a load on the subject than ever before. [Solution] This system is provided with: an inertial sensor 31 that is attached to a predetermined part in a subject 1B who is an object person of a learning for the purpose of determining an acceleration rate and an angular velocity of the predetermined part; inertial sensors 32, 33 that are respectively attached to the right and left thighs of the subject 1B for the purpose of determining acceleration rates and angular velocities respectively of the right and left thighs of the subject 1B; and a learning estimation device 2. The learning estimation device 2 calculates a correct angle formed between the predetermined part in the subject 1B and each of the right and left thighs of the subject 1B on the basis of the above-determined acceleration rates and angular velocities, and performs a mechanical learning using the acceleration rate and the angular velocity of the predetermined part in the subject 1B as input data and also using the correct angle as correct data, thereby generating a learned model. Subsequently, an acceleration rate and an angular velocity of a predetermined part in an estimation object person 1A are input into the learned model to estimate an object angle formed between the predetermined part in the estimation object person 1A and each of the right and left thighs of the estimation object person 1A.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

A care support server acquires a plurality of data sets each of which indicates a first condition for a case where a first physical reaction is seen in a person with speech difficulties and a first thought of the person with speech difficulties for a case where the first physical reaction is seen, and generates an inference model by machine learning in which the first condition indicated in each of the plurality of data sets is used as an explanatory variable and the first thought indicated in each of the plurality of data sets is used as an objective variable. The care support server then inputs input data indicating a second condition for a case where a second reaction is seen to the inference model to infer a second thought for the case where the second reaction is seen, and outputs the inference result.

IPC Classes  ?

• G06N 5/045 - Explanation of inferenceExplainable artificial intelligence [XAI]Interpretable artificial intelligence
• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation

Abstract

An inspection device (1) comprises a storage unit (16) for storing a mechanical property inference model that is generated by machine learning based on mechanical property information and nondestructive inspection information of a first composite material including reinforcement fibers, the mechanical property information and the nondestructive inspection information being known, and that is for use in inferring, through reception as input of nondestructive inspection information of a second composite material which includes reinforcement fibers and has unknown mechanical property information, the mechanical property information of the second composite material. The inspection device acquires the nondestructive inspection information of the second composite material, inputs said nondestructive inspection information to the mechanical property inference model, acquires the mechanical property information of the second composite material from the mechanical property inference model, and performs output based on said mechanical property information.

IPC Classes  ?

• G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
• G01N 3/02 - Investigating strength properties of solid materials by application of mechanical stress Details
• G01N 29/04 - Analysing solids
• G01N 29/11 - Analysing solids by measuring attenuation of acoustic waves
• G01N 29/12 - Analysing solids by measuring frequency or resonance of acoustic waves
• G01N 29/44 - Processing the detected response signal

Abstract

One embodiment of the present invention provides a diamond formation device that comprises a reaction vessel and an electrode unit. The reaction vessel holds: a starting material liquid that includes a carbon source; and a substrate that is provided in the starting material liquid. The electrode unit can generate plasma in the starting material liquid, and the substrate has at least one recess in a principal surface that is opposite the electrode unit. Another embodiment of the present invention provides a diamond-coated substrate that comprises: a substrate that has at least one recess in a principal surface; and diamond that is directly formed on the principal surface of the substrate.

IPC Classes  ?

• C30B 29/04 - Diamond
• C01B 32/26 - Preparation
• C23C 16/27 - Diamond only
• C23C 16/50 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges

Abstract

[Problem] To provide a novel target protein degradation inducing compound, a composition for cancer therapy that includes said compound, and in particular a composition for cancer therapy that does not cause serious teratogenicity. [Solution] A thalidomide derivative that demonstrates reduced degradation of both SALL4 and PLZF proteins would serve as an E3 ligase binder of a target protein degradation inducing compound that is capable of avoiding serious teratogenicity. Using this knowledge, the present invention was achieved by finding a thalidomide derivative that has a reduced degradation ability with regard to both SALL4 and PLZF proteins, and further confirming that a target protein degradation inducing compound that includes said derivative has an anti-cancer effect.

IPC Classes  ?

• A61P 35/00 - Antineoplastic agents
• C07D 495/14 - Ortho-condensed systems
• A61K 9/02 - SuppositoriesBougiesBases for suppositories or bougies
• A61K 9/10 - DispersionsEmulsions
• A61K 9/12 - AerosolsFoams
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 9/70 - Web, sheet or filament bases
• A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep

Abstract

Malaria transmission-blocking vaccines with good preservation stability and immunostimulatory action are provided. According the present invention, combination use of a pharmaceutical composition comprising (4E,8E,12E,16E,20E)-N-{2-[{4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]benzyl}(methyl)amino]ethyl}-4,8,12,17,21,25-hexamethylhexacosa-4,8,12,16,20,24-hexaeneamide, or a pharmaceutically acceptable salt thereof, as a vaccine adjuvant with enhanced specific immune response against antigens and good preservation stability and a malaria vaccine with non-glycosylation, homogeneity, and biological activity allow for the provision of malaria transmission-blocking vaccines with good preservation stability and immunostimulatory action.

IPC Classes  ?

• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 39/015 - Hemosporidia antigens, e.g. Plasmodium antigens
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61P 33/06 - Antimalarials

Abstract

The purpose of the present invention is to provide a compound that can be suitably used in a fluorochrome or similar, a novel fluorochrome and kit for conveniently detecting cells, and a novel method for conveniently detecting cells or similar.　A compound represented by formula (1) or a salt thereof. (In formula (1), R1is a substituted or unsubstituted C1-12 alkyl group or similar, R2and R3are each independently a substituted or unsubstituted C1-6 alkyl group or similar, R4and R5 are each independently a C1-12 alkyl group or similar, n is an integer from 1 to 4, and a and b are each independently an integer from 0 to 4.)

IPC Classes  ?

• C07D 295/112 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulfur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
• A61K 51/04 - Organic compounds
• C09B 57/00 - Other synthetic dyes of known constitution
• C09B 67/20 - Preparations of organic pigments
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers

Abstract

The present invention provides a cart making it possible to perform bedside cleaning and endoscope transportation. The present invention is for transporting an endoscope Z having an insertion part Z1 to be inserted into the body cavity and an operation part Z2 for operating the insertion part Z1, and has a placement part 2 on which a container bag B1 containing a cleaning liquid is placed, and a holding part 3 for holding the operation part Z2 above the placement part 2. The operation part Z2 is held by the holding part 3, and the insertion part Z1 is immersed in the cleaning liquid in the container bag B1.

IPC Classes  ?

• A61B 50/20 - Holders specially adapted for surgical or diagnostic appliances or instruments
• A61B 90/70 - Cleaning devices specially adapted for surgical instruments
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/12 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with cooling or rinsing arrangements

Abstract

An object of the present invention is to provide a new means for suppressing inhibition of proliferation of keratinocytes even when the keratinocytes start to come into contact with each other. The present invention solves the above problem by culturing keratinocytes in contact with a common medium with fibroblasts treated with a composition containing a specific compound.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 31/7016 - Disaccharides, e.g. lactose, lactulose
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells

Abstract

Provided are a CAR library used to screen scFvs that can be functional in CAR-T cells, and an scFv manufacturing method in which the CAR library is used. A chimeric antigen receptor (CAR) library of the present invention includes nucleic acids coding for first CARs. Each of the first CARs includes a first antigen-binding domain, a first transmembrane domain, and a first intracellular signaling domain. The first antigen-binding domain includes a first single-chain antibody (scFv) to be screened for the ability to bind to a target antigen. The first scFv includes a first heavy-chain variable region and a first light-chain variable region. The first heavy-chain variable region and the first light-chain variable region meet a predetermined condition.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 14/725 - T-cell receptors
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12N 15/62 - DNA sequences coding for fusion proteins
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Abstract

A magnetic memory device includes a first magnetic memory device, a second magnetic memory device, a pulse power supplying current pulses to the first and second magnetic memory devices; and a switch configured to selectively connect the pulse power to one of the first and second magnetic memory devices. A resistance value of an MTJ device composed of the first fixed layer, the first non-magnetic layer, and the free layer is different from a resistance value of a MTJ device composed of the second fixed layer, the second non-magnetic layer, and the free layer.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• H10N 50/10 - Magnetoresistive devices
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 50/80 - Constructional details
• H10N 50/85 - Materials of the active region

Abstract

Provided is a blue light-emitting material for organic light-emitting diode (OLED) comprising a phosphinine derivative and the OLED including the same. The light-emitting material for OLED of the present invention comprises the phosphinine derivative having an electron-withdrawing substituent at its C4 position of a phosphorus-containing six-membered ring. The OLED of the present invention has a pair of electrodes and organic layers including light-emitting layers between the pair of the electrodes, wherein the at least one light-emitting layer comprises an anthracene compound and the phosphinine derivative.

IPC Classes  ?

• H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• C07F 9/6568 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms

Abstract

h being formed with a size that enables a liquid to be held by surface tension. Therefore, by irradiating the detection unit 10 with light, it is possible to obtain transmitted light L2 that has been transmitted through a liquid film Lf. By analyzing the transmitted light L2, a target component in a sample L can be appropriately quantified.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 21/03 - Cuvette constructions
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01N 33/558 - ImmunoassayBiospecific binding assayMaterials therefor using diffusion or migration of antigen or antibody
• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G01N 37/00 - Details not covered by any other group of this subclass

Abstract

[Problem] To alleviate, more than heretofore, the burden on a caregiver when an ICT device is used by a person who has difficulty speaking, such as a severely mentally/physically handicapped child or a dementia patient. [Solution] In the present invention, a caregiving assistance server 2 generates an inference model by: acquiring a plurality of data sets indicating a first condition at the time of a first bodily reaction of a person who has difficulty speaking, and indicating a first thought of the person who has difficulty speaking at that time; and performing machine learning by using the first condition as an explanatory variable and the first thought as a target variable, which are indicated in each of the plurality of data sets. By inputting, to the inference model, input data indicating a second condition at the time of a second reaction, a second thought at the time of the second reaction is inferred, and a caregiver terminal device outputs the inference results.

IPC Classes  ?

• G09B 21/00 - Teaching, or communicating with, the blind, deaf or mute
• G06N 5/04 - Inference or reasoning models
• G06N 20/00 - Machine learning
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06F 3/048 - Interaction techniques based on graphical user interfaces [GUI]
• G06F 3/16 - Sound inputSound output

Abstract

[Problem] To provide a structure that enables a small sample to be used in a variety of fields. [Solution] The present invention comprises a main body part 10 having a through-hole region part 11 which has through holes 11h that pass through the front and back of a substrate 10a, and a liquid supply part 12 which is continuous with the through-hole region part 11. The main body part 10 has a plurality of cavities 10h through which, via capillary action, can pass a liquid L in communication with the through holes 11h in the substrate 10a. The through holes 11h are formed to have a size such that the through holes 11h can cold the liquid via surface tension. Thus, when the liquid is supplied to the main body part 10, it is possible to form a liquid film Lf in the through holes 11h of the through-hole region part 11.

IPC Classes  ?

• B05D 1/02 - Processes for applying liquids or other fluent materials performed by spraying
• B05D 3/00 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
• B01D 24/00 - Filters comprising loose filtering material, i.e. filtering material without any binder between the individual particles or fibres thereof
• B01D 29/00 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor
• G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
• G01N 1/34 - PurifyingCleaning
• G01N 21/03 - Cuvette constructions
• G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection

Abstract

The present invention relates to providing a new method for easily detecting tumor cells in tissue from a living body. The present invention includes a fluorescent dye containing a compound that exhibits solvatochromism for detecting tumor cells in tissue. The present invention also includes a method for staining tissue derived from a living body or applying to a living body the fluorescent dye to detect tumor cells or specify the range of tumor removal.

IPC Classes  ?

• C09K 9/02 - Organic tenebrescent materials
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• C07D 295/112 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulfur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
• C09B 57/00 - Other synthetic dyes of known constitution
• C09B 67/20 - Preparations of organic pigments
• A61K 51/04 - Organic compounds
• G01N 1/30 - StainingImpregnating
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
• G01N 21/64 - FluorescencePhosphorescence

Abstract

The present disclosure comprises: a monoclonal antibody or an antibody fragment that binds to an epitope consisting of 5-20 consecutive amino acids in an amino acid sequence of SEQ ID NO: 1; and a method for detecting or quantifying a malaria vaccine antigen derived from Ripr, the method including bringing the antibody into contact with a sample.

IPC Classes  ?

• C07K 16/20 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 33/06 - Antimalarials
• C07K 16/46 - Hybrid immunoglobulins
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• C12N 15/13 - Immunoglobulins

Abstract

Provided is a device for inspecting a composite material, it being possible to use the device to evaluate a composite material by inferring mechanical properties of the composite material without measuring the mechanical properties.　The inspection device comprises a storage unit for storing a mechanical property inference model generated by machine learning based on mechanical property information and nondestructive inspection information of a first composite material, which is reinforced with reinforcing fibers and for which the mechanical property information and the nondestructive inspection information are known, the mechanical property inference model inferring the mechanical property information of a second composite material which is reinforced with reinforcing fibers and for which the mechanical property information is unknown, with the nondestructive inspection information of the second composite material as input; and the nondestructive inspection information of the second composite material in acquired, the nondestructive inspection information is input to the mechanical property inference model, the mechanical property information of the second composite material is acquired from the mechanical property inference model, and output based on the mechanical property information is made.

IPC Classes  ?

• G01N 3/06 - Special adaptations of indicating or recording means

Abstract

The present invention reliably releases the grip of a clip main body on a biological tissue regardless of the orientation of the clip main body. A removal loop part 4 is pulled into a sheath 2, from a state in which a clip 10 is disposed within the opening of the removal loop part 4 so as to be further toward the sheath side than is a narrow part 41. Thus the narrow part 41 is used to move a tightening ring 12 to the rear side of the clip main body 11 so that the grip of the clip main body 11 on the biological tissue is released.

IPC Classes  ?

• A61B 17/128 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for applying or removing clamps or clips

Abstract

Malaria transmission-blocking vaccines with good preservation stability and immunostimulatory action are provided. According the present invention, combination use of a pharmaceutical composition comprising (4E,8E,12E,16E,20E)-N-{2-[{4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]benzyl}(methyl)amino]ethyl}-4,8,12,17,21,25-hexamethylhexacosa-4,8,12,16,20,24-hexaeneamide, or a pharmaceutically acceptable salt thereof, as a vaccine adjuvant with enhanced specific immune response against antigens and good preservation stability and a malaria vaccine with non-glycosylation, homogeneity, and biological activity allow for the provision of malaria transmission-blocking vaccines with good preservation stability and immunostimulatory action.

IPC Classes  ?

• A61K 39/015 - Hemosporidia antigens, e.g. Plasmodium antigens
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61P 33/06 - Antimalarials

Abstract

Provided is a method for producing transformed cells, comprising an introduction step of contacting an introduction liquid comprising a molecule of interest with a target cell to introduce the molecule of interest into the target cell, wherein, in the introduction step, the molecule of interest is introduced via endocytosis into the target cell, a trait is conferred, deleted, or maintained by the introduction of the molecule of interest, and the molecule of interest such as a vector added exogenously does not then remain in an established cell.

IPC Classes  ?

• C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

An object of the present invention is to provide an analysis method capable of analyzing time-series images by a method simpler than ever. A computer program that is an application example of the present invention is a computer program for an image processing device including a storage unit that stores therein image data including time-series computed tomography (CT) images in a plurality of frames, of an organ of a subject captured after a contrast medium has been administered causes the image processing device to execute: a first step of determining a change-over-time of a CT value on the basis of image data including CT images in the plurality of frames; a second step of determining a predetermined slope that is a slope of the CT value with respect to a predetermined time on the basis of a change-over-time of the CT value determined in the first step; and a third step of approximating a change-over-time of the CT value with a predetermined function on the basis of the predetermined slope determined in the second step.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]
• G06T 11/00 - 2D [Two Dimensional] image generation

Abstract

The present invention relates to a rhinovaccination system for preventing and treating hepatitis B, comprising a hepatitis B vaccine composition for administration to nasal mucosa in combination with a medical nozzle device.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• A61K 9/12 - AerosolsFoams
• A61K 39/12 - Viral antigens
• A61K 39/29 - Hepatitis virus
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers

Abstract

Provided is a method for introducing a selected molecule, including: an inhibitor treatment step of allowing a target cell or a target tissue to internalizing an inhibitor of vesicular transport or lysosomal membrane fusion; and an introduction step of contacting an introduction liquid containing a selected molecule with the target cell or the target tissue to introduce the selected molecule into the target cell or the target tissue.

IPC Classes  ?

• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
• C12N 9/99 - Enzyme inactivation by chemical treatment

Abstract

Provided is a metal surface pre-treatment agent that can promptly form a zinc-containing film on the surface of a metal material, the metal surface pre-treatment agent moreover being such that applying a lubricant to the film yields exceptional lubricating properties.　A metal surface pre-treatment agent that is to be used in a pre-treatment for bringing a zinc-compound-containing film-forming treatment agent into contact with the surface of a metal material to form a zinc-containing film, the surface pre-treatment agent being an aqueous liquid containing an alkali component that includes at least one type from among calcium, potassium, and sodium.

IPC Classes  ?

• B21C 23/32 - Lubrication of metal being extruded or of dies, or the like, e.g. physical state of lubricant, location where lubricant is applied
• C23C 22/48 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH < 6 not containing phosphates, hexavalent chromium compounds, fluorides or complex fluorides, molybdates, tungstates, vanadates or oxalates
• C23C 22/56 - Treatment of aluminium or alloys based thereon
• C23C 22/78 - Pretreatment of the material to be coated

Abstract

According to an embodiment of the present invention, there is provided a device for forming at least a diamond film on a surface of a substrate, the device comprising: a container configured to hold a raw material liquid and to place the substrate in the raw material liquid; an electrode part comprising a positive electrode and a negative electrode and configured to generate a plasma in the raw material liquid; a raw material gas supply part and a carrier gas supply part, each of the raw material gas supply part and the carrier gas supply part being connected to the electrode part; and a power source configured to apply a voltage to the electrode part, wherein the power source is a direct current power source, and the electrode part further comprises an adjunctive member, and the adjunctive member is attached to an electrode at a plasma generation region of the electrode part.

IPC Classes  ?

• C23C 16/27 - Diamond only
• C23C 16/513 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using plasma jets
• C30B 25/02 - Epitaxial-layer growth
• C30B 29/04 - Diamond
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H05H 1/24 - Generating plasma
• H10D 62/83 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group IV materials, e.g. B-doped Si or undoped Ge

Abstract

[Object] An object is to provide a sulfonated fine cellulose fiber having excellent transparency, a sulfonated pulp fiber suitable for the sulfonated fine cellulose fiber, a method for producing these fibers, and a derivative pulp containing the sulfonated pulp fiber. [Means for achieving the object] The sulfonated pulp fiber of the present invention is a pulp fiber comprising a plurality of cellulose fibers, wherein a part of hydroxyl groups of the cellulose fibers of the pulp fiber is substituted with sulfo groups, an introduction amount of sulfur attributable to the sulfo groups is adjusted to be higher than 0.42 mmol/g while maintaining a fiber shape, and a water retention value of the pulp fiber is adjusted to 150% or more. Since the sulfonated pulp fiber has a predetermined water retaining property or more while maintaining the fiber shape, the degree of flexibility in handling can be improved.

IPC Classes  ?

• C08B 5/14 - Cellulose sulfate
• D21H 11/20 - Chemically or biochemically modified fibres

Abstract

[Problem] To provide a functional sheet that allows for easy erasure and correction of ink applied to a surface thereof while impeding erasure after a certain amount of time, and to provide a production method therefor. [Solution] The invention provides a sheet member whereby permeation of a liquid may be controlled, having a sheet surface layer 3 positioned on a base material surface layer. The sheet surface layer 3 is provided with a flow path 3h whereby permeation of a liquid, inward from the surface 3s of the sheet surface layer 3, may be controlled. Since the sheet surface layer 3 is provided with the flow path 3h whereby permeation of a liquid may be controlled, the erasing time for liquid applied on the sheet surface can be controlled.

IPC Classes  ?

• B05D 3/00 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
• B05D 3/02 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
• B05D 3/12 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by mechanical means
• B05D 5/04 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain a surface receptive to ink or other liquid
• B05D 7/00 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
• B05D 7/24 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials for applying particular liquids or other fluent materials
• B32B 5/24 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer

Abstract

An artificial knee 1 is provided with: an insert member 2 that is buried in a portion of the joint surface of the medial condyle MC or lateral condyle LC of the tibia T; and a bridge member 3 that is placed underneath the insert member 2 and that has a length that allows anchoring of both ends of the bridge member to the cortical bone of the tibia T.

IPC Classes  ?

• A61F 2/38 - Joints for elbows or knees

Abstract

The present invention addresses the problem of providing a novel means for preventing the inhibition of the proliferation of keratinocytes even when the keratinocytes begin to contact with each other.　The present invention can solve the problem by culturing keratinocytes while bringing the keratinocytes into contact with a common culture medium with fibroblasts that have been treated with a composition containing a specific compound.

IPC Classes  ?

• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• A61P 11/02 - Nasal agents, e.g. decongestants
• A61P 15/02 - Drugs for genital or sexual disordersContraceptives for disorders of the vagina
• A61P 27/02 - Ophthalmic agents
• A61P 27/16 - Otologicals
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07H 3/04 - Disaccharides
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 31/7016 - Disaccharides, e.g. lactose, lactulose

Abstract

[Problem] To provide a spectral analysis chip capable of quantitatively analyzing a small amount of a sample through spectral analysis. [Solution] An analysis tool used for spectral analysis is provided with a detection unit 10 that has through-holes 10h formed so as to penetrate a base material 11 from front to back. The detection unit 10 has, inside the base material 11, a plurality of gaps 11h which are connected with the through-holes 10h and through which a liquid can pass by means of a capillary phenomenon. The through-holes 10h are each formed of a size so as to be able to hold the liquid by means of surface tension force. Thus, since transmission light L2 transmitted through a liquid film Lf can be acquired by irradiating the detection unit 10 with light, a target component in a sample L can be appropriately quantified by analyzing the transmission light L2.

IPC Classes  ?

• G01N 37/00 - Details not covered by any other group of this subclass
• G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation
• G01N 21/03 - Cuvette constructions

Abstract

Provided is a novel cancer marker for testing the risk of developing a cancer.　This cancer marker includes at least one substance selected from the group consisting of anti-HIRIP3 antibodies, HIRIP3, anti-FNDC11 antibodies, FNDC11, anti-SLC1A3 antibodies, SLC1A3, anti-TMEM33 antibodies, TMEM33, anti-ABCF1 antibodies, ABCF1, anti-CFDP1 antibodies, CFDP1, anti-POLR3GL antibodies, POLR3GL, anti-CADM1 antibodies, CADM1, anti-RNF128 antibodies, RNF128, anti-ATP6V1B1 antibodies, and ATP6V1B1.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C12N 15/12 - Genes encoding animal proteins
• C12N 15/13 - Immunoglobulins
• G01N 33/15 - Medicinal preparations
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Provided is a complexed protein that is capable of imparting, to an antibody or an antigen-binding fragment thereof, a binding ability to a desired antigen.　The complexed protein according to the present invention contains a first antigen-binding domain and a second antigen-binding domain, wherein the first antigen-binding domain is capable of binding to immunoglobulin while the second antigen-binding domain is capable of binding to the desired antigen.

IPC Classes  ?

• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C07K 16/42 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against immunoglobulins (anti-idiotypic antibodies)
• C07K 16/46 - Hybrid immunoglobulins
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• C12N 15/13 - Immunoglobulins
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

The present invention relates to a hepatitis B vaccine composition for spray-administration to nasal mucosa for preventing and treating hepatitis B, which comprises hepatitis B antigen and carboxy vinyl polymer.

IPC Classes  ?

• A61P 31/20 - Antivirals for DNA viruses
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 39/29 - Hepatitis virus
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

Provided are: a CAR library used in screening of scFv, which can function in CAR-T cells; and a production method for scFv using the CAR library. The chimera antigen receptor (CAR) library according to the present invention includes nucleic acid encoding a first CAR. The first CAR includes a first antigen-binding domain, a first transmembrane domain, and a first intracellular signal transduction domain. The first antigen-binding domain includes a first single-chain antibody (scFv) for screening of binding to a target antigen. The first scFv includes a first heavy-chain variable region and a first light-chain variable region. The first heavy-chain variable region and the first light-chain variable region satisfy a predetermined condition.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C07K 16/46 - Hybrid immunoglobulins
• C07K 19/00 - Hybrid peptides
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 15/13 - Immunoglobulins
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms
• G01N 33/531 - Production of immunochemical test materials
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
• C12P 21/08 - Monoclonal antibodies

Abstract

A functional material for testing a liquid sample includes a based material in a sheet shape and a channel part provided on a mounting surface of the base material wherein the channel part is composed with water-permeable fibers having permeability, and water-impermeable fibers having impermeability. The water-permeable fibers and the water-impermeable fibers are arranged along the longitudinal direction of the channel part, forming voids wherein the voids are in a mesh structure in which one of the voids connects to another of the voids such that the empty spaces are linked from a base end to a tip end of the channel part. A thickness of the channel part is ranged from 20 μm mm to 5 mm, and a width of the voids is ranged from 10 μm to 200 μm, allowing the liquid sample to move from the base end to the tip end due to capillarity.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor

Abstract

Provided is a visual field test device in which it is possible to maintain a high level of accuracy of visual tests. This visual field test device has: a display unit 2; a detection unit 3 which detects whether or not a test subject has recognized a test optotype being displayed on the display unit 2; and a display control unit 10 which controls the timing and position at which the test optotype is to be displayed on the display unit 2. The control display unit 10 has: a test optotype display function 11 for causing test optotypes to be displayed alternately at a reference position and a peripheral position; and a reaction time measurement function 14 for measuring the time it takes for the test subject to recognize a test optotype after the test optotype have been displayed at the peripheral position. The display position of a reference test optotype and the display position of a peripheral test optotype are associated with each other and stored as a single set of information. The test optotype display function 11 comprises a display position adjustment function 12 which is for adjusting the display position of the reference test optotype and the display position of the peripheral test optotype on the basis of the relation between the display unit 2 and the display position of the peripheral test optotype.

IPC Classes  ?

• A61B 3/024 - Subjective types, i.e. testing apparatus requiring the active assistance of the patient for determining the visual field, e.g. perimeter types

Abstract

Provided is an illumination instrument that is for use in endoscopic surgery, and that enables a practitioner during an endoscopic surgery, regardless of the amount of experience of the practitioner, to place the leading end of a light-emitting part at a desired detachment planned site on the back side of an organ, for causing light emitted from the light-emitting part to transmit from the back side to the front side of the organ and for illuminating, in a spot-like manner, "a site indicated by the transmitted light" on the front side of the organ as the "detachment site" on the back side of the organ, so as to enable pinpoint identification of the "detachment site" located on the back side of the organ, from the front side of the organ. This illumination instrument for use in endoscopic surgery is provided with: a grip part having a light source embedded therein; and a light-emitting part that is formed in a long and thin rod-like shape, that has a base end side thereof connected to the grip part and the leading end serving as a contact part which comes into contact with the back side of the organ, and that guides light from the light source so as to emit light, wherein the light emitted from the leading end of the light-emitting part is configured to be capable of transmitting to the front side of the organ.

IPC Classes  ?

• A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 17/94 - Endoscopic surgical instruments

Abstract

Provided is a transformed cell production method comprising an introduction step of bringing an introduction liquid containing a molecule of interest into contact with a target cell to introduce the molecule of interest into the target cell. In the introduction step, after the molecule of interest is introduced into the target cell by endocytosis and a trait is conferred, deleted or maintained by the introduced molecule of interest, the foreign molecule of interest (e.g. vector) does not remain in the established cell.

IPC Classes  ?

• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Abstract

The present invention relates to a transnasal administration system which can be used for the prevention and treatment of hepatitis B and is combined with a medical nozzle device for use in the administration of a hepatitis B vaccine composition to the nasal cavity mucosa, wherein the hepatitis B vaccine composition is intended to be administered with a trans-nasal-mucosa spray.

IPC Classes  ?

• A61K 39/29 - Hepatitis virus
• A61K 9/06 - OintmentsBases therefor
• A61K 9/12 - AerosolsFoams
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61P 31/20 - Antivirals for DNA viruses

Abstract

The purpose of the present invention is to provide an analysis method capable of analyzing time-series images through a more convenient method than before. A computer program is one among application examples of the present invention and is for an image processing device provided with a storage means which stores image data comprising CT images of a prescribed number of frames according to a time series, which are obtained by imaging an organ of a subject after a contrast agent has been administered. The computer program causes the image processing device to execute: a first step in which a temporal change of a CT value is specified on the basis of image data comprising CT images of a prescribed number of frames; a second step in which a prescribed slope is specified as a slope of CT values for a prescribed time on the basis of the temporal change of the CT values, which has been specified in the first step; and a third step in which the temporal change of the CT values are approximated to a prescribed function on the basis of the prescribed slop that has been specified in the second step.

IPC Classes  ?

• A61B 6/03 - Computed tomography [CT]

Abstract

[Problem] To provide: sulfonated fine cellulose fibers having excellent transparency; sulfonated pulp fibers suitable for these sulfonated fine cellulose fibers; methods for producing these fibers; and a derivative pulp comprising said sulfonated pulp fibers. [Solution] The sulfonated pulp fibers of the present invention are pulp fibers which comprise a plurality of cellulose fibers and in which some of the hydroxyl groups of the cellulose fibers have been replaced with sulfo groups. The pulp fibers have a content of sulfo-group-derived introduced sulfur atoms higher than 0.42 mmol/g while retaining the fibrous shape. The pulp fibers have a water retentivity degree of 150% or higher. Since the sulfonated pulp fibers have a water retentivity not lower than the given value while retaining the fibrous shape, the degree of freedom of handleability can be improved.

IPC Classes  ?

• C08B 5/14 - Cellulose sulfate
• D21H 11/20 - Chemically or biochemically modified fibres

Abstract

To enable calculation of the photosynthesis rate of a plant with a simple configuration, the present invention provides a photosynthesis rate measurement system capable of measuring carbon dioxide concentrations. This system is designed to measure the photosynthesis rate of a plant and is provided with a cover unit for covering the plant, a case, and a sensor for alternately measuring the carbon dioxide concentrations inside and outside the cover unit, wherein the sensor is provided within the case, and an air stirring unit for stirring air flowing into the case is provided on the inside of the case.

IPC Classes  ?

• A01G 7/00 - Botany in general
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry

Abstract

An ultrasonic inspection method of scanning and inspecting an inspection object with ultrasonic waves includes collecting data obtained by scanning the inspection object with ultrasonic signals by using probes configured to transmit and receive the ultrasonic signals to and from the inspection object via a medium that propagates the ultrasonic signals; and processing and synthesizing the collected data. Synthesizing the data includes depicting an image including a surface of the inspection object in a region including pixels partitioned in a grid-like fashion based on the collected data of the ultrasonic signals, and extracting a pixel having maximum pixel intensity from the pixels arranged along a direction perpendicular to an extending direction of the surface of the inspection object in the depicted image to identify a position of the extracted pixel as a surface shape of the inspection object.

IPC Classes  ?

• G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
• G01N 29/11 - Analysing solids by measuring attenuation of acoustic waves
• G01N 29/44 - Processing the detected response signal
• G01N 29/26 - Arrangements for orientation or scanning

Abstract

According to one embodiment of the present invention, a device for forming at least a diamond film on the surface of a base material is provided. The device is configured by having: a container for holding a raw material liquid and disposing the base material in the raw material liquid; an electrode unit for generating plasma in the raw material liquid, said electrode unit being provided with a positive electrode and a negative electrode; a raw material gas supply unit and a carrier gas supply unit, which are connected to the electrode unit; and a power supply for applying a voltage to the electrode unit. The power supply is a direct current power supply, the electrode unit is also provided with an additional member, and the additional member is attached to the electrode of the electrode unit, said electrode being positioned in a region where the plasma is generated.

IPC Classes  ?

• C01B 32/26 - Preparation
• C23C 16/27 - Diamond only
• C23C 16/513 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using plasma jets
• H01L 21/205 - Deposition of semiconductor materials on a substrate, e.g. epitaxial growth using reduction or decomposition of a gaseous compound yielding a solid condensate, i.e. chemical deposition
• H05H 1/24 - Generating plasma

Abstract

This method for introducing a selected molecule comprises: an inhibitor treatment step for allowing an inhibitor of vesicular transport or lysosomal membrane fusion to enter a target cell or target tissue; and an introduction step for bringing an introduction liquid containing the selected molecule into contact with the target cell or target tissue, and introducing the selected molecule into the target cell or target tissue.

IPC Classes  ?

• C12N 15/09 - Recombinant DNA-technology
• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
• C12N 5/07 - Animal cells or tissues

Abstract

The present invention relates to a hepatitis B vaccine composition for nasal mucosa spraying administration, characterized by comprising a hepatitis B antigen and a gel base containing a carboxyl vinyl polymer, and by being applicable to hepatitis B prevention and treatment.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 9/12 - AerosolsFoams
• A61K 39/29 - Hepatitis virus
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61P 31/20 - Antivirals for DNA viruses
• A61P 37/04 - Immunostimulants

Abstract

The purpose of the present invention is to provide an ultrasound examination method and an ultrasound examination device capable of simultaneously displaying a plurality of flaws located at different sites in a single still image, while leveraging the advantages and overcoming the weaknesses of conventional back propagation analysis. The ultrasound examination method of the present invention uses ultrasonic waves to locate flaws inside a test specimen, and is characterized by comprising: a step for preparing a model of the test specimen; a step for setting and inputting a measurement condition for the ultrasonic waves; a step for controlling an ultrasonic probe in accordance with the measurement condition to emit incident ultrasonic waves into the test specimen and receive reflected waves of the incident waves; a step for performing a back propagation analysis on the model using waveform signals of the reflected waves, and creating a group of back propagation still images arranged in reverse-chronological order; a step for performing a forward propagation analysis on the model using waveform signals of the incident waves, and creating a group of forward propagation still images arranged in chronological order; and a step for calculating to combine the group of forward propagation still images and the group of back propagation still images to create a single still image showing the locations of the flaws.

IPC Classes  ?

• G01N 29/52 - Processing the detected response signal using inversion methods other than spectral analysis, e.g. conjugated gradient inversion

Abstract

This hepatitis B vaccine includes surface antigen particles formed in which only L-proteins of the hepatitis B virus, or mutants of said L-proteins, collect on the lipid membrane.

IPC Classes  ?

• A61K 39/29 - Hepatitis virus
• A61P 31/20 - Antivirals for DNA viruses
• C07K 14/02 - Hepadnaviridae, e.g. hepatitis B virus
• C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor

Abstract

The problem of providing a novel molecule having high specificity to CLDN-5 and capable of recognizing an extracellular domain of CLDN-5 can be solved by an antibody capable of specifically recognizing the three-dimensional structure or the primary structure of an extracellular domain of Claudin-5 protein.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07K 16/46 - Hybrid immunoglobulins
• C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 5/12 - Fused cells, e.g. hybridomas
• C12N 15/13 - Immunoglobulins

Abstract

The present invention provides a polypeptide and a malaria vaccine comprising said polypeptide, the polypeptide comprising any of the following amino acid sequences: (a) an amino acid sequence represented by SEQ ID NO. 4; (b) an amino acid sequence represented by SEQ ID NO. 4, in which 1-10, preferably 1-5, and more preferably 1-3 amino acids have been substituted, deleted, added or inserted; and (c) an amino acid sequence having at least 95%, preferably at least 97%, and more preferably at least 99% sequence identity with SEQ ID NO. 4.

IPC Classes  ?

• C12N 15/09 - Recombinant DNA-technology
• A61K 39/015 - Hemosporidia antigens, e.g. Plasmodium antigens
• A61K 39/13 - Poliovirus
• C07K 14/445 - Plasmodium
• C07K 16/20 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
• C07K 17/02 - Peptides being immobilised on, or in, an organic carrier
• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A61K 39/05 - CorynebacteriumPropionibacterium
• A61K 39/08 - Clostridium, e.g. Clostridium tetani
• A61K 39/10 - BrucellaBordetella, e.g. Bordetella pertussis
• A61P 33/06 - Antimalarials
• A61P 37/04 - Immunostimulants
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

A cubic boron nitride (cBN) polycrystalline body according to the present invention is a non-orientation polycrystalline body composed of cBN single-phase crystal structures having an average grain diameter of 200 nm or less, and has a Knoop hardness of 50 GPa or more. The Knoop hardness can be adjusted to 53 GPa or more by adjusting the average grain diameter to 100 nm or less, and it makes it possible to use the polycrystalline body suitably as a sharp cutting tool cutting edge or the like by adjusting the average grain diameter to 50 nm or less. A Knoop hardness of 54.5 GPa or more can be achieved in a cBN polycrystalline body in which cBN coarse crystal grains having an average grain diameter of 120 to 165 nm are dispersed in cBN fine polycrystalline structures having an average grain diameter of 70 nm or less and the average grain diameter of the polycrystalline body including the fine polycrystalline structures and the coarse crystal grains is 100 nm or less. The cBN polycrystalline body according to the present invention can be produced by retaining a raw material, which is composed of pyrolytic boron nitride (pBN) and is oriented in the [001] direction, at a predetermined temperature for a predetermined time period under a pressure of 25 GPa or more to convert pBN to cBN directly.

IPC Classes  ?

• C04B 35/5831 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on borides, nitrides or silicides based on boron nitride based on cubic boron nitride
• B01J 3/00 - Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matterApparatus therefor
• B23B 27/14 - Cutting tools of which the bits or tips are of special material
• B23B 27/20 - Cutting tools of which the bits or tips are of special material with diamond bits
• B24D 3/00 - Physical features of abrasive bodies, or sheets, e.g. abrasive surfaces of special natureAbrasive bodies or sheets characterised by their constituents
• C01B 21/064 - Binary compounds of nitrogen with metals, with silicon, or with boron with boron

Abstract

The present invention provides a polypeptide and a malaria vaccine comprising said polypeptide, the polypeptide comprising any of the following amino acid sequences: (a) an amino acid sequence represented by SEQ ID NO. 4 or SEQ ID NO. 8; (b) an amino acid sequence represented by SEQ ID NO. 4 or SEQ ID NO. 8, in which 1-10, preferably 1-5, and more preferably 1-3 amino acids have been substituted, deleted, added or inserted; and (c) an amino acid sequence having at least 95%, preferably at least 97%, and more preferably at least 99% sequence identity with SEQ ID NO. 4 or SEQ ID NO. 8.

IPC Classes  ?

• C12N 15/09 - Recombinant DNA-technology
• A61K 39/015 - Hemosporidia antigens, e.g. Plasmodium antigens
• A61K 39/13 - Poliovirus
• C07K 14/445 - Plasmodium
• C07K 16/20 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
• C07K 17/02 - Peptides being immobilised on, or in, an organic carrier
• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A61K 39/05 - CorynebacteriumPropionibacterium
• A61K 39/08 - Clostridium, e.g. Clostridium tetani
• A61K 39/10 - BrucellaBordetella, e.g. Bordetella pertussis
• A61P 33/06 - Antimalarials
• A61P 37/04 - Immunostimulants
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

A hybrid material according to the present invention has: a metal substrate that includes at least one of a metal capable of becoming a divalent ion and a metal capable of becoming a trivalent ion; and a layered double hydroxide layer that is formed on a surface of the metal substrate and is obtained by alternately layering a base layer and an intermediate layer, said base layer being obtained by bonding divalent metal ions, trivalent metal ions, and hydroxide ions, and said intermediate layer being obtained by bonding negative ions and water molecules, said hybrid material being characterized in that at least one of the divalent metal ions and the trivalent metal ions making up the base layer are metal ions that have been ionized by a portion of the metal included in the metal substrate.

IPC Classes  ?

• C01F 7/00 - Compounds of aluminium
• C01G 3/00 - Compounds of copper
• C01G 9/00 - Compounds of zinc
• C23C 22/60 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using alkaline aqueous solutions with pH > 8
• C23C 22/68 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous solutions with pH between 6 and 8
• C23C 22/78 - Pretreatment of the material to be coated
• C23C 26/00 - Coating not provided for in groups

Abstract

The purpose of the present invention is to provide an elastic wave measurement and analysis method and device that make it possible to accurately locate an elastic wave source even if unexpected errors occur in some sensors from among a plurality of sensors. An elastic wave measurement and analysis method according to the present invention is a method for locating an elastic wave source by measuring and analyzing the elastic waves emitted from an object to be inspected using a plurality of sensors disposed on the surface of the object to be inspected, said method being characterized by having: a step for measuring the waveform signals of the elastic waves; a step for temporarily storing the waveform signals; a step for saving the temporarily stored waveform signals at an interval of a prescribed unit measurement time; a step for reading a temporal region including waveform signals to be used for propagation analysis; a step for determining whether a prescribed error signal is included in any of the read waveform signals; a step for creating an adjusted waveform signal from a read waveform signal determined to include the error signal by replacing the error signal portion with prescribed dummy data; a step for creating temporally inverted waveform signals by temporally inverting the adjusted waveform signal and waveform signals; and a step for carrying out backpropagation analysis on the temporally inverted waveform signals in a model of the object to be inspected.

IPC Classes  ?

• G01N 29/14 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object using acoustic emission techniques
• G01N 29/44 - Processing the detected response signal

Abstract

[Problem] In the conventional culture and/or livestock feeds containing larvae and/or pupae of insects such as fly, the optimum content of insect larvae and/or pupae is approximately 0.5-25 wt% in dry weight with respect to the total amount of the feed, while feeding a feed containing insect larvae and/or pupae in an amount exceeding this range would pose the problem of slow growth for the animal being fed therewith. Further, it is true that insects may contain polysaccharides exhibiting high immunostimulating activity; however, even when such insects are provided as is as food or by being included in aquaculture and/or livestock feeds, there are cases where expected immunostimulating effects were not produced. [Solution] The present invention provides a method for producing a composition for a food product and/or a feed that uses insects as a raw material, said method comprising a step for removing a lipophilic component contained in the insects by means of a solvent.

IPC Classes  ?

• A23L 35/00 - Foods or foodstuffs not provided for in groups Preparation or treatment thereof
• A23K 10/20 - Animal feeding-stuffs from material of animal origin
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 35/64 - Insects, e.g. bees, wasps or fleas
• A61P 37/04 - Immunostimulants

Abstract

An analysis method is provided that ensures objective and quantitative analysis for analyzing time-series images. For implementing the method are provided an image data storage unit that stores therein image data on a plurality of time-series computed tomography (CT) images of an organ of a subject captured after a contrast medium has been administered; a target pixel extraction unit configured to extract an intra-organ pixel position, which is a position of a pixel in a region of the organ; a change-over-time determining unit configured to determine a change-over-time of a CT value of the pixel at the determined intra-organ pixel position, based on image data on the time series CT images in the plurality of frames; and a function approximation processing unit configured to determine an arrival time at which the contrast medium has arrived at an organ at the intra-organ pixel position and a base value, which is a CT value serving as a base of the pixel at the intra-organ pixel position, based on the determined change-over-time.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61B 6/03 - Computed tomography [CT]
• G06T 7/11 - Region-based segmentation
• A61B 5/0402 - Electrocardiography, i.e. ECG
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment

Abstract

h), which allows the anterior cruciate ligament (ACL) to be reconstructed so as to be in the substantially same state as a knee replaced for the artificial knee joint (1).

IPC Classes  ?

• A61F 2/38 - Joints for elbows or knees
• A61F 2/30 - Joints

Abstract

h. In addition, components other than a desired component can be separated and removed from a mixture present in the liquid sample while the liquid sample is allowed to move. Therefore, a water-absorbing function and a filtering function can be imparted to the channel part 10.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• B81B 7/00 - Microstructural systems
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor

Abstract

In this ultrasonic diagnostic system that serves as a medical treatment system, symbols for a planned puncture path and symbols for an existing puncture path are displayed on a cross-sectional image. The symbols of the existing puncture path include a projection image, an intersection image, a proximal end marker, and a distal end marker. Changing the location and attitude of a probe causes the display locations of the symbols for the existing puncture path to change relative to the symbols for the planned puncture path, and causes the display mode of the symbols for the existing puncture path to change.

IPC Classes  ?

• A61B 8/14 - Echo-tomography

Abstract

Provided is a means for detecting hepatitis B virus at a high accuracy. A method for detecting or assaying hepatitis B virus in a biological sample, said method comprising detecting or assaying an oligopeptide comprising an amino acid sequence represented by any of SEQ ID NOS: 1-7 by mass spectrometry.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 14/02 - Hepadnaviridae, e.g. hepatitis B virus
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

[Problem] To provide a visual field measuring method and visual field measuring apparatus which are able to reduce the burden on a tested person and a testing technician, and to provide an optotype that enables minimum separable acuity obtained as a test result to coincide with a retinal resolution, and is suited to automatic measuring and the visual field measuring method and visual field measuring apparatus according to the present invention. [Solution] This method for measuring the visual field comprises: a reference optotype display step of causing a test optotype to be displayed at a reference position BP located in the center of a display unit 2; a reference input step of causing the tested person to provide an input of the fact that the tested person has recognized the test optotype displayed in the reference optotype display step; a peripheral optotype display step of causing a test optotype to be displayed at a position different from the reference position BP if the fact that the test optotype is recognized is inputted in the reference input step; and a peripheral input step of causing the tested person to provide an input of the fact that the tested person has recognized the test optotype displayed in the peripheral optotype display step. A reaction time from the displaying of the test optotype in the peripheral optotype display step to the input of the fact that the test optotype is recognized in the peripheral input step is measured.

IPC Classes  ?

• A61B 3/024 - Subjective types, i.e. testing apparatus requiring the active assistance of the patient for determining the visual field, e.g. perimeter types
• A61B 3/032 - Devices for presenting test symbols or characters, e.g. test chart projectors

Abstract

Provided is a new means for effectively treating diseases including autoimmune diseases and the like. This peptide fragment has an amino acid sequence from position 46 to position 73, an amino acid sequence from position 160 to position 181, or an amino acid sequence from position 235 to position 261 in the amino acid sequence of carbonic anhydrase I (CAI), and includes 35 amino acid residues or less.

IPC Classes  ?

• C12N 9/88 - Lyases (4.)
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cellsMyeloid precursor cellsAntigen-presenting cells, e.g. dendritic cells
• A61K 35/64 - Insects, e.g. bees, wasps or fleas
• A61K 35/66 - Microorganisms or materials therefrom
• A61K 35/741 - Probiotics
• A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• A61K 36/06 - Fungi, e.g. yeasts
• A61K 38/43 - EnzymesProenzymesDerivatives thereof
• C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 5/0784 - Dendritic cellsProgenitors thereof
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 15/09 - Recombinant DNA-technology

Abstract

Provided is an artificial knee joint (1) used in total artificial knee joint replacement, comprising: a femoral member (10) attached to a femoral distal end (DT); a tibial member (20) attached to a tibial proximal end (PE); and an artificial ligament (30) that connects the tibial member (20) and the femoral member (10). One end of the artificial ligament (30) is connected at a position, on the inside of the lateral condyle of the femoral member (10), where the anterior cruciate ligament (ACL) was located in the knee before replacement by the artificial knee joint (1), and the other end is connected at a position, above the tibial member (20), where the anterior cruciate ligament (ACL) was located in the knee before replacement by the artificial knee joint (1).

IPC Classes  ?

• A61F 2/38 - Joints for elbows or knees
• A61F 2/08 - MusclesTendonsLigaments

Abstract

　Provided is a water-absorbing resin resin composition that contains, water-absorbing resin particles (A), which are a polymer of water soluble ethylenically unsaturated monomers having at least type of acid group, and a high molecular amine compound (B), wherein the degree of neutralization of the acid group of the water-absorbing resin particles (A) is not more than 90 mol%, and the aqueous solution viscosity of 0.5 mass% of the high molecular amine compound (B) ranges from 1 to 500 Pa·s.

IPC Classes  ?

• C08L 101/14 - Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity the macromolecular compounds being water soluble or water swellable, e.g. aqueous gels
• A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators
• A61F 13/49 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators characterised by the shape specially adapted to be worn around the waist, e.g. diapers, nappies
• A61F 13/53 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators characterised by the absorbing medium
• B01J 20/26 - Synthetic macromolecular compounds
• C08L 5/04 - Alginic acidDerivatives thereof
• C08L 101/02 - Compositions of unspecified macromolecular compounds characterised by the presence of specified groups

Abstract

Provided is an analysis technique that ensures objectivity and quantitativeness in analyzing time-series images. The invention comprises: an image data storage unit (11) that stores image data of a plurality of time-series CT images obtained by capturing images of an organ of a subject to which a contrast medium has been administered; a target pixel extraction unit (31) that extracts an intra-organ pixel position which is the position of a pixel within a region of the organ; a change-over-time specifying unit (33) that specifies a change over time in the CT value of the pixel at the specified intra-organ pixel position on the basis of image data of a plurality of frames of the time-series CT images; and a functionalization processing unit (37) that specifies, on the basis of the specified change over time, an arrival time at which the contrast medium reached the organ at the intra-organ pixel position and a base value which is the CT value serving as a basis for the pixel at the intra-organ pixel position.

IPC Classes  ?

• A61B 6/03 - Computed tomography [CT]

Abstract

Provided is an artificial knee joint with which it is possible to restore the anterior cruciate ligament to a state of functionality close to the original, using an artificial knee joint. This artificial knee joint (1) is designed for use in total knee replacement surgery, wherein: the artificial knee joint (1) is provided with a femur member (10) and a tibia member (20); and a ligament passage hole (20h) that passes through the tibia member (20) is formed in the tibia member (20), at the location where the anterior cruciate ligament (ACL) was present in the knee prior to replacement with the artificial knee joint (1). This makes it possible, by passing the ligament through the ligament passage hole (20h), to position the ligament so as to link the distal tip (DT) of the femur (F) and the proximal end (PE) of the tibia (T), whereby it is possible to restore the anterior cruciate ligament (ACL) to a state substantially identical to that of the knee prior to replacement with the artificial knee joint (1).

IPC Classes  ?

• A61F 2/38 - Joints for elbows or knees

Abstract

[Problem] To provide a functional material endowed with the function of high-accuracy detection of a predetermined substance present in a sample, even in a small sample size, as well as to provide a method of producing said functional material. [Solution] In the present invention, provided is a flow channel section (10) through which a liquid is allowed to flow. The flow channel section (10) is formed of water-permeable materials (11) containing water-impermeable materials (12). The water-impermeable materials (12) are disposed between the water-permeable materials (11), and therefore gaps (10h) can be formed between the water-impermeable materials (12) and water-permeable materials (11). In other words, net-shaped gaps (10h) can be formed within the flow channel section (10). If a liquid sample is supplied to the flow channel section (10), the liquid sample moves while penetrating through these gaps (10h). In addition, unintended components can be separated and removed from a mixture present in the liquid sample, while the liquid sample is being moved. Therefore, it is possible to impart a water absorption function and filter function to the flow channel section (10).

IPC Classes  ?

• G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• G01N 37/00 - Details not covered by any other group of this subclass

Abstract

The purpose of the present invention is to provide a new analytical method which renders simple analysis for 3-hydroxyproline possible. A sample to be examined is analyzed for 3-hydroxyproline through the following steps (s1) to (s3): (s1) a dehydration step in which the 3-hydroxyproline contained in the sample to be examined is dehydrated into Δ1-pyrroline-2-carboxylic acid by the action of a 3-hydroxyproline dehydratase; (s2) a reduction step in which the Δ1-pyrroline-2-carboxylic acid obtained in step (s1) is hydrogenated by the action of a Δ1-pyrroline-2-carboxylic acid reductase; and (s3) an analysis step in which the reduction reaction in step (s2) is analyzed.

IPC Classes  ?

• C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase
• C12N 9/06 - Oxidoreductases (1.), e.g. luciferase acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
• C12N 9/88 - Lyases (4.)
• C12N 15/09 - Recombinant DNA-technology
• C12Q 1/527 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving lyase

Abstract

　[Problem] To provide a PLC signal repeating system capable of performing stable power line communication by suppressing attenuation of a PLC signal as much as possible. [Solution] A PLC signal repeating system according to the present embodiment is provided with a bypass line (40) electrostatically coupled to the ground, and a bypass device (31) having a branch line coupler (34) coupled to a branch line (16) by capacitative coupling or inductive coupling and a bypass line coupler (32) coupled to the bypass line (40) by inductive coupling, the bypass device (31) transmitting a PLC signal between the branch line (16) and the bypass line (40). The PLC signal flows in a closed loop circuit (42) formed by the bypass line (40) and the ground so that communication is performed by bypassing signal attenuating devices (11, 12) installed on a power line network (10).

IPC Classes  ?

• H04B 3/56 - Circuits for coupling, blocking, or by-passing of signals

Abstract

Provided is an apparatus for manufacturing magnetic zeolite that makes recovery possible easily through magnetic separation, has high adsorption capacity per unit weight, and makes it possible to efficiently manufacture magnetic zeolite, which is zeolite having a magnetic property. The apparatus for manufacturing magnetic zeolite has at least a magnetic precursor synthesis reactor for synthesizing a magnetic precursor, a zeolite precursor synthesis reactor for synthesizing a zeolite precursor, a magnetic zeolite synthesis reactor for synthesizing magnetic zeolite from the magnetic precursor and the zeolite precursor, a magnetic precursor supply line for supplying the magnetic precursor synthesized in the magnetic precursor synthesis reactor toward the magnetic zeolite synthesis reactor, and a zeolite supply line for supplying the zeolite precursor synthesized in the zeolite precursor synthesis reactor toward the magnetic zeolite synthesis reactor.

IPC Classes  ?

• C01B 39/00 - Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolitesTheir preparationAfter-treatment, e.g. ion-exchange or dealumination
• B01J 20/18 - Synthetic zeolitic molecular sieves
• B01J 20/30 - Processes for preparing, regenerating or reactivating

Abstract

[Problem] To provide a liquid-liquid extracting method and a liquid-liquid extracting device that has a simple structure that does not require a driving unit and can process a large volume of a solution for extraction. [Solution] A liquid-liquid extracting device that brings two liquids that are separated by an interface formed therebetween into contact and extracts a substance from one liquid into the other liquid, said liquid-liquid extracting device comprising an extracting unit (10) that has a plurality of extraction channels (10h) for passing two liquids (S, E), a liquid supplying unit (13) for supplying a liquid to the extracting unit (10), and a liquid discharging unit (14) for discharging the liquids (S, E) from the extracting unit (10). The extracting unit (10) is formed so that the cross-sectional area of the extraction channels (10h) changes in the direction of flow. Since the cross-sectional area of the extraction channels (10h) changes, the area of the interface between the two liquids flowing in the extraction channels (10h) can be changed, and a convective flow (CV) can be generated in each liquid. Thus, the extraction efficiency between the two liquid can be improved just by flowing the two liquids (S, E).

IPC Classes  ?

• B01D 11/04 - Solvent extraction of solutions which are liquid

Abstract

A magnetized zeolite being a composite material of magnetite nanoparticles and a Na-P1-type zeolite is obtained by: adding an alkaline solution to a zeolite raw material including incinerated coal ash or incinerated paper-making sludge ash and softening the surface of the incinerated ash; and mixing magnetite nanoparticles and the zeolite raw material having the incinerated ash surface thereof softened, and heat treating same. The magnetized zeolite has a structure whereby magnetite nanoparticles are locked in the particle boundary of a polycrystalline body of the Na-P1-type zeolite, a structure whereby some magnetite nanoparticles are substituted inside the Na-P1-type zeolite crystals and a nano complex is formed therein, or both of these structures.

IPC Classes  ?

• C01B 39/02 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereofDirect preparation thereofPreparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactantsAfter-treatment thereof
• B01J 20/18 - Synthetic zeolitic molecular sieves
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01J 20/30 - Processes for preparing, regenerating or reactivating
• B03C 1/00 - Magnetic separation
• B03C 1/18 - Magnetic separation acting directly on the substance being separated with material carriers in the form of belts with magnets moving during operation
• G21F 9/06 - Processing
• G21F 9/12 - Processing by absorptionProcessing by adsorptionProcessing by ion-exchange
• G21F 9/28 - Treating solids

Abstract

The present invention addresses the problem of providing an ophthalmic composition that holds promise for having a long-lasting effect and therapeutic effect on serious cases and is efficacious in treating dry eye. The ophthalmic composition comprises as an active ingredient a compound having a moisture adjusting effect in a digestive tract. A preferable example of the compound having a moisture adjusting effect in a digestive tract is a member selected from among bisacodyl, picosulfate and pharmaceutically acceptable salts thereof. The active ingredient of the ophthalmic composition according to the present invention can increase tear volume in an eye to be treated. When bisacodyl or picosulfate is used as the active ingredient of the ophthalmic composition according to the present invention, an increase in tear volume can be observed several minutes to several hours, for example 3 hours, after instillation.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 9/08 - Solutions
• A61K 31/4402 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
• A61P 27/04 - Artificial tearsIrrigation solutions

Abstract

A loop antenna (10) comprises an antenna element (12) configured by forming a uniplanar loop from a conductive line on the surface of a dielectric substrate, the contours of the loop including protruding sections (14a, 14b, 14c, 14d) protruding in four directions in the shape of a cross. A power supply unit (17) for connecting the power supply line is provided at one location on an internal corner formed by the conductive line in the antenna element (12). Thus, it is possible to significantly decrease the size of the loop antenna in comparison to conventional antennas without compromising antenna characteristics such as the impedance and emission characteristics.

IPC Classes  ?

• H01Q 7/00 - Loop antennas with a substantially uniform current distribution around the loop and having a directional radiation pattern in a plane perpendicular to the plane of the loop
• H01Q 1/38 - Structural form of radiating elements, e.g. cone, spiral, umbrella formed by a conductive layer on an insulating support
• H01Q 9/40 - Element having extended radiating surface
• H01Q 9/42 - Resonant antennas with feed to end of elongated active element, e.g. unipole with folded element, the folded parts being spaced apart a small fraction of the operating wavelength

Abstract

A novel method is provided which is able to manufacture an artificial skin model including dendric cells. In the method for manufacturing the artificial skin model, coated cells are cultured whose cell surface is coated with a coating containing an extracellular matrix component, a dermal tissue layer is formed on which these coated cells are layered, type IV collagen is brought into contact with the dermal tissue layer to form a basal layer containing type IV collagen on the dermal tissue layer, and epidermal cells are arranged on the basal layer to form an epidermal layer. At the very least either the dermal tissue layer or the epidermal layer contains dendric cells.

IPC Classes  ?

• C12N 5/0784 - Dendritic cellsProgenitors thereof
• A61L 27/00 - Materials for prostheses or for coating prostheses
• C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
• C12N 5/07 - Animal cells or tissues

Abstract

Provided is a method with which pure (single-phase) hexagonal diamond can be obtained in a size (in bulk) large enough to be industrially applicable. Graphite which is highly crystalline and highly oriented, i.e. having a mosaic spread of 5˚ or less, is used as a starting material, and a temperature in the range of 1000-1500˚C is imparted thereto under a pressure in the range of 20-25GPa. The size of the single-phase hexagonal-diamond bulk sintered body obtained using this method depends upon the size of the highly oriented/highly crystalline graphite starting material, but as long as the pressure and temperature can be wholly imparted (i.e. the size of a pressurized chamber of a high-pressure/high-temperature imparting device permitting), an arbitrary size can be obtained.

IPC Classes  ?

• C04B 35/52 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on carbon, e.g. graphite
• B01J 3/06 - Processes using ultra-high pressure, e.g. for the formation of diamondsApparatus therefor, e.g. moulds or dies
• C01B 31/06 - Diamond
• C04B 35/645 - Pressure sintering
• C30B 35/00 - Apparatus not otherwise provided for, specially adapted for the growth, production or after-treatment of single crystals or of a homogeneous polycrystalline material with defined structure

Abstract

A nanometer-size-particle production apparatus is provided which can prevent the occurrence of waste fluids, and which makes quick and continuous syntheses feasible while suppressing damages to the electrode. The present invention is a nanometer-size-particle production apparatus for synthesizing nanometer-size particles in a liquid by means of plasma in liquid, and comprises: a container for accommodating the liquid therein; an electromagnetic-wave generation device for generating a high-frequency wave, or a microwave; an electrode conductor whose leading end makes contact with the liquid to supply the high-frequency wave or the microwave to the liquid; a covering portion being disposed into the liquid so as to cover a leading-end upside of the electrode conductor; a metallic chip being composed of a metal making a raw material of nanometer-size particles, and having a leading end that is disposed to face to a leading-end section of the electrode conductor; and a feed device for feeding out the leading end of the metallic chip with respect to the leading-end section of the electrode conductor; the leading end of the electrode conductor having a configuration that is a non-edge configuration; and the electrode conductor, except for the leading end, having an axially-orthogonal cross-sectional area that is larger than an axially-orthogonal cross-sectional area of the metallic chip.

IPC Classes  ?

• B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
• C01G 9/02 - OxidesHydroxides
• H05H 1/46 - Generating plasma using applied electromagnetic fields, e.g. high frequency or microwave energy
• B22F 9/14 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using physical processes using electric discharge
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C01F 5/14 - Magnesium hydroxide
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor

Abstract

This invention provides a plant health diagnostic method and a plant health diagnostic device for detecting initial disorder of a plant individual body carrying pests or the like in a large-scale plant cultivation field. The plant health diagnostic method is for diagnosing a health state of a plant in accordance with chlorophyll fluorescence emitted from chlorophyll of a plant body. The method includes: obtaining a first minimum point s after a maximum point p having largest chlorophyll fluorescence intensity and a first maximum point m after the minimum point s on a time course curve for the chlorophyll fluorescence intensity; defining chlorophyll fluorescence intensity values at the minimum point s and the first maximum point m after the minimum point s as S and M, respectively; and comparing the value S and the value M to evaluate the state of the plant. The state of the plant, which cannot be visually recognized from outer appearance, can be detected by comparison between the chlorophyll fluorescence intensity values (S and M), thereby realizing diagnosis of the state of the plant individual body in an early stage.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G01N 21/64 - FluorescencePhosphorescence
• A01G 7/00 - Botany in general
• G06T 7/00 - Image analysis
• G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited

Abstract

Zeolite capable of selective, specific and efficient capture of radioactive cesium in soil or a liquid containing soil, and a method of capturing cesium are provided. A material (7) for the synthesis of a magnetized Na-P1 zeolite composite is obtained by mixing an iron compound with any of: coal incineration ash or paper-making sludge incineration ash; a mixture prepared using coal incineration ash or paper-making sludge incineration ash and sodium aluminate and/or aluminum hydroxide to adjust the Si/Al ratio to 2 or less; or, a mixture prepared using multiple of water glass, sodium aluminate and an aluminum compound to adjust the Si/Al ratio to 2 or less. A magnetized Na-P1 zeolite composite (11) containing crystals of Na-P1 zeolite (5) and crystals of magnetite (9) is obtained by using a sodium hydroxide solution (3) to perform alkali treatment. After the magnetized Na-P1 zeolite composite (11) is mixed into the soil containing radioactive cesium or a liquid containing said soil, recovery is performed by magnetic separation.

IPC Classes  ?

• C01B 39/02 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereofDirect preparation thereofPreparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactantsAfter-treatment thereof
• B01J 20/18 - Synthetic zeolitic molecular sieves
• B01J 20/30 - Processes for preparing, regenerating or reactivating
• C01D 17/00 - Rubidium, caesium, or francium compounds
• G21F 9/06 - Processing
• G21F 9/12 - Processing by absorptionProcessing by adsorptionProcessing by ion-exchange
• G21F 9/28 - Treating solids

Abstract

The present invention addresses the problem of providing: an imine compound which is a surfactant that is usable in emulsion polymerization and is able to be easily decomposed after use by means of a weak acid such as an organic acid; an imine micelle which contains the imine compound; an emulsion which contains the imine micelle; an emulsion polymerization method which uses the emulsion; and an aldehyde compound that is a synthesis intermediate of the imine compound. An emulsion polymerization method of the present invention is characterized by comprising: a step of obtaining an imine micelle from a specific aldehyde compound and a basic amino acid in an aqueous solvent; and a step of emulsion polymerizing an ethylene monomer in an emulsion that contains the imine micelle.

IPC Classes  ?

• C08F 2/24 - Emulsion polymerisation with the aid of emulsifying agents
• C07C 47/575 - Compounds having —CHO groups bound to carbon atoms of six-membered aromatic rings containing ether groups, groups, groups, or groups
• C07C 251/24 - Compounds containing nitrogen atoms doubly- bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
• C07D 213/75 - Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates