Abstract

The purpose of the present invention is to provide: a composite hollow fiber membrane that maintains high levels of both permeability of liquid organic solvents and ability to block solutes in organic solvent-based liquids to be treated; and a method for manufacturing the composite hollow fiber membrane. This composite hollow fiber membrane comprises: an aliphatic polyamide hollow fiber membrane that has a dense layer and a support layer; and a functional separation layer that includes a cross-linked resin obtained through interfacial polycondensation. The functional separation layer is disposed on a surface of the dense layer, and the burst pressure measured under the following conditions is at least 2.25 MPa. Burst pressure: while N-methyl-2-pyrrolidone is passed into a module formed by using the composite hollow fiber membrane, pressure is raised 0.25 MPa at a time at ten-minute intervals, and the pressure (MPa) when the composite hollow fiber membrane ruptures is measured.

IPC Classes  ?

• B01D 69/08 - Hollow fibre membranes
• B01D 63/02 - Hollow fibre modules
• B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/56 - Polyamides, e.g. polyester-amides
• C08J 9/26 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out

Abstract

This seed treatment agent or soil treatment agent for controlling blight in small grain cereals is highly safe for small grain cereals, simple and efficient with a small labor load, and capable of exhibiting an excellent blight control effect. Said agent contains probenazole as an active ingredient. This method for controlling blight in small grain cereals includes treating, before sowing seeds of small grain cereals, the seeds or soil using the seed treatment agent or soil treatment agent for controlling blight in small grain cereals.

IPC Classes  ?

• A01N 43/80 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
• A01C 1/00 - Apparatus, or methods of use thereof, for testing or treating seed, roots, or the like, prior to sowing or planting
• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
• A01P 3/00 - Fungicides

Abstract

[Problem] To provide a temperature output device that makes it possible to know the temperature of each virtual area in a single air-conditioned space. [Solution] A temperature output device 10 comprises: a temperature acquisition unit 11 that acquires an area temperature that is the temperature of each of a plurality of areas into which a single air-conditioned space 50 is divided; and an output unit 12 that outputs the area temperature acquired by the temperature acquisition unit 11. Thus, each person present in the air-conditioned space 50 can know the area temperature of each area, and can move to an area having a temperature at which the person feels comfortable.

IPC Classes  ?

• F24F 11/80 - Control systems characterised by their outputsConstructional details thereof for controlling the temperature of the supplied air

Abstract

The present invention provides a prophylactic and/or therapeutic agent for a skin disorder associated with a histone deacetylase 4 abnormality. This prophylactic and/or therapeutic agent for a skin disorder associated with a histone deacetylase 4 abnormality contains a histone acetyltransferase inhibitor as an active ingredient. This prophylactic and/or therapeutic agent makes it possible to prevent and/or treat a skin disorder associated with a histone deacetylase 4 abnormality.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/121 - Ketones acyclic
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 31/365 - Lactones
• A61K 31/4155 - 1,2-Diazoles not condensed and containing further heterocyclic rings
• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61K 31/60 - Salicylic acidDerivatives thereof
• A61P 17/00 - Drugs for dermatological disorders
• A61P 17/16 - Emollients or protectives, e.g. against radiation
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C12N 9/99 - Enzyme inactivation by chemical treatment
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/15 - Medicinal preparations
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present invention provides, inter alia, a method for screening a substance that suppresses intramuscular adipose tissue (IMAT) formation. Provided are: a method for screening a substance that suppresses IMAT formation, the method comprising: (I) a step for bringing a Wnt5b protein, an Ror2 protein, and a test substance into contact with each other; and (II) a step for confirming that the test substance inhibits binding of the Wnt5b protein and Ror2 protein; and a composition for suppressing IMAT formation.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61P 21/04 - Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• G01N 33/15 - Medicinal preparations
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present invention provides a novel memory disorder ameliorating agent.　A PKCγ activity inhibitor is useful as an active ingredient for a memory disorder ameliorating agent.

IPC Classes  ?

• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C12N 9/99 - Enzyme inactivation by chemical treatment

Abstract

Provided is a component useful as an ATP scavenger and/or an ADP scavenger.　Transferrin is useful as an adenosine triphosphate scavenger, and butyrylcholinesterase is effective as an adenosine diphosphate scavenger.

IPC Classes  ?

• A61K 38/40 - Transferrins, e.g. lactoferrins, ovotransferrins
• A61K 38/46 - Hydrolases (3)
• A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors
• A61P 9/08 - Vasodilators for multiple indications
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• A61P 39/02 - Antidotes
• C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)
• C12Q 1/46 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase involving cholinesterase

Abstract

The purpose of the present invention is to provide a method for selectively identifying an immune reaction to a specific antigen, at the level of antibody sequences, from repertoire data for immune cell receptors. An immune reaction to a specific antigen can be selectively identified, at the level of antibody sequences, by this immune reaction evaluation method, the method including: a step A for preparing repertoire data of sequences for antigen recognition sites in immune cell receptors, wherein the repertoire data is acquired from a sample collected from a subject; and a step B for collating database of a sequence for an antigen recognition site against a specific antigen with the repertoire data to identify a sequence which is identical to the sequence included in the database or a sequence of which a portion excluding two or less amino acid residues is identical to the sequence included in the database at the level of amino acid sequences.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12N 15/44 - Orthomyxoviridae, e.g. influenza virus
• C12N 15/50 - Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

Provided is an artificial biological membrane containing a membrane protein retaining lateral diffusivity. Also provided is a method of producing an artificial biological membrane containing a membrane protein retaining lateral diffusivity. The artificial biological membrane is obtained by a method of producing an artificial biological membrane, the method including a step of partially laminating a polymer lipid membrane (b) on the surface of a substrate (a), followed by the lamination of a fluid lipid membrane (c) on the surface of the substrate (a), on which the polymer lipid membrane (b) is not laminated, together with a peptide nanodisc and a membrane protein (d). The membrane protein (d) is reconstituted in the produced artificial biological membrane at a high probability, and retains lateral diffusivity.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol

Abstract

Provided is a low-cost, favorably efficient production method for cellobiose. The method includes a step for reacting sucrose in a reaction liquid that contains glucose isomerase and yeast that has been made to express sucrose phosphorylase and cellobiose phosphorylase on the surface thereof.

IPC Classes  ?

• C12N 15/54 - Transferases (2)
• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12N 9/92 - Glucose isomerase
• C12P 19/12 - Disaccharides

Abstract

Provided is a bidirectional DC-DC converter having excellent performance for extending a voltage doubler characteristic in a discharge mode and a voltage divider characteristic in a charge mode over a wide range, and improving a voltage conversion ratio for use in a wide range of inputs/outputs. In an interleaved bidirectional DC-DC converter, a maximum limit or a minimum limit of an ON-time ratio, of drive pulses of a portion of switches to be controlled individually for each of a charge mode and a discharge mode, is asymmetrically provided with respect to an amplification value of an error between a combined value and a reference value of an inductor current of each phase, and the maximum limit or the minimum limit is switched.

IPC Classes  ?

• H02M 3/155 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only

Abstract

An object is to realize a novel reverse osmosis membrane (more specifically, reverse osmosis composite membrane) that is capable of suppressing biofouling. The object is attained with use of a reverse osmosis composite membrane which is obtained by chemically modifying a surface thereof with a compound that has an amino group and that is obtained by modifying the amino group with two molecules of α-picolyl group and has a dipicolylamine structure.

IPC Classes  ?

• B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 69/12 - Composite membranesUltra-thin membranes

Abstract

2-42-42-4halogenated hydrocarbon; an alcohol compound reaction step for reacting the oxidative photodecomposition product with an alcohol compound; and a base addition step for adding an inorganic base after the alcohol compound reaction step or adding an organic base at least after the oxidative photodecomposition step.

IPC Classes  ?

• C07C 68/00 - Preparation of esters of carbonic or haloformic acids
• C07C 69/96 - Esters of carbonic or haloformic acids
• C07B 61/00 - Other general methods

Abstract

The present invention provides a method for selecting a promoter that functions in an organelle, the method comprising: (1) the step of preparing sequence information obtained by RNA sequencing analysis; (2) the step of mapping the sequence information prepared in the step (1) onto a sequence of organellar DNA; (3) the step of calculating the amount of change in RNA expression in each region based on the mapping information obtained in the step (2); (4) the step of selecting regions in which the amount of change obtained in the step (3) is within a range of preset reference values; and (5) the step of identifying a region, among the regions selected, as a promoter functioning in an organelle.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The purpose of the present disclosure is to provide a production method by which hollow fine particles that contain a perfluoro resin and have a large average particle diameter and a single pore structure can be produced. The present disclosure provides a method for producing hollow fine particles, the method comprising: a step A for obtaining a dispersion liquid by dispersing, in water, a solution that contains a perfluoro monomer and a non-polymerizable solvent which has an SP value of 9.00 to 9.80 (cal/cm3)1/2 and is capable of dissolving the perfluoro monomer; a step B for obtaining phase-separated fine particles that contain a perfluoro resin and have a single pore structure by polymerizing the perfluoro monomer; and a step C for obtaining hollow fine particles that have a single pore structure by removing the non-polymerizable solvent from the phase-separated fine particles.

IPC Classes  ?

• B01J 13/14 - Polymerisation, crosslinking
• C08F 216/14 - Monomers containing only one unsaturated aliphatic radical
• C08F 224/00 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygen
• C08L 27/12 - Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogenCompositions of derivatives of such polymers not modified by chemical after-treatment containing fluorine atoms
• C08L 101/00 - Compositions of unspecified macromolecular compounds

Abstract

The purpose of the present invention is to provide: a composite hollow fiber membrane, in which the liquid permeability of an organic solvent and the blocking performance of a solute in an organic solvent-based liquid to be treated are both achieved to a great extent; and a method for manufacturing the same. This composite hollow fiber membrane includes: a polyamide hollow fiber membrane having a dense layer and a support layer; and a silicone layer. The silicone layer is provided on the surface of the dense layer.

IPC Classes  ?

• B01D 69/08 - Hollow fibre membranes
• B01D 61/14 - UltrafiltrationMicrofiltration
• B01D 63/02 - Hollow fibre modules
• B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/56 - Polyamides, e.g. polyester-amides
• B01D 71/70 - Polymers having silicon in the main chain, with or without sulfur, nitrogen, oxygen or carbon only
• C08J 9/26 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
• C08J 9/36 - After-treatment

Abstract

The present disclosure provides technology for adjusting the immune system of a subject. The present disclosure provides a composition that is for adjusting the immune system of a subject and that comprises titanium peroxide nanoparticles (TiOx NPs). The present disclosure also provides a composition that is for enhancing immunostimulation exhibited by other medical means administered to a subject and that comprises titanium peroxide nanoparticles (TiOx NPs).

IPC Classes  ?

• A61K 33/40 - Peroxides
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A61P 37/04 - Immunostimulants
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

An ion analysis method according to one embodiment of the present invention comprises: an ionization step for ionizing an object to be measured; an ion input step for inputting ions obtained in the ionization step or objective ions that are ions derived from said ions to a moving space (30) having a predetermined gas pressure adjusted within a range that allows particles to perform Brownian motion, and allowing the gravity and an electric field to act; a measurement step for acquiring first information on the motion by the action of the gravity and the electric field with respect to the objective ions inputted to the moving space, and acquiring second information on the Brownian motion; and a computation step for determining the mass or electric charge of the objective ions on the basis of the first and second information acquired in the measurement step. As a result, it is possible to accurately and efficiently measure the mass and electric charge of ions such as macromolecules and viruses.

IPC Classes  ?

• G01N 15/10 - Investigating individual particles
• G01N 27/622 - Ion mobility spectrometry
• H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

Abstract

A data processing device includes an instruction issue circuit configured to issue instructions; a plurality of execution circuits configured to execute, in parallel, the instructions issued from the instruction issue circuit; and a plurality of delay circuits configured to delay arrival timings of when the instructions issued from the instruction issue circuit arrive at the plurality of execution circuits, the plurality of delay circuits being arranged between the instruction issue circuit and the plurality of execution circuits. The arrival timings of the instructions arriving at at least two execution circuits included in the plurality of execution circuits are different from each other.

IPC Classes  ?

• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead

Abstract

21211 of the outside balloon 2.

IPC Classes  ?

• A61M 25/10 - Balloon catheters

Abstract

Provided is a cannula with which it is possible to effectively and antegradely send blood from the ascending aorta, while reducing the diameter. This cannula, in which the distal end part thereof is disposed in the ascending aorta and blood fed from an external-membrane-type artificial lung is sent antegradely from the ascending aorta, comprises an antegrade blood return part 2 and a blood-sending tube 4, the antegrade blood return part 2 being provided at the distal end of the blood-sending tube 4. A guide wire tube 5 extending in the longitudinal direction from the base end part to the distal end part is disposed substantially at the center of the axis inside the antegrade blood-sending cannula 1. The blood-sending tube 4 is a tube provided on the base end side connected to the extracorporeal-membrane-type artificial lung. The antegrade blood return part 2 reverses the blood in the antegrade direction from the reverse direction and directs the blood toward the base end side, and is composed of a first blood return tube 6 provided on the base end side and a second blood return tube 7 provided on the distal side. The second blood return tube 7 is provided with a side hole 7a and a side hole 7b, and a part of a substantially hemispherical bag body 8 is adhered to the inside of the distal end.

IPC Classes  ?

• A61M 60/178 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices

Abstract

The present invention makes it possible, even when the electrode arrangement is different from a predetermined electrode arrangement, to obtain a necessary multi-channel biological signal. A biological-signal-processing system according to the present disclosure is provided with: m electrodes that are attached to a living body in a first arrangement; and a signal-processing device that executes a process of inputting a p-channel first biological signal acquired from the m electrodes into a generation model and outputting a q-channel second biological signal from the generation model. The q-channel second biological signal is a signal corresponding to a signal obtained from n (n is an integer of 3 or more) electrodes attached to the living body in a second arrangement. The second arrangement is an electrode arrangement different from the first arrangement in terms of at least one of the number of electrodes and the attachment positions. The generation model is configured to output a q-channel second biological signal when a p-channel first biological signal is input.

IPC Classes  ?

• A61B 5/327 - Generation of artificial ECG signals based on measured signals, e.g. to compensate for missing leads

Abstract

The purpose of the present invention is to provide: a method for easily producing a high quality polyurethane including an isosorbide structure without using an isocyanate; and a high quality polyurethane that includes an isosorbide structure and that can be produced without using an isocyanate. A method for producing an isosorbide polyurethane according to the present invention is characterized by comprising a step for reacting an isosorbide-containing fluorinated alkyl biscarbonate, a soft segment polyamine monomer, and a hard segment polyamine monomer, and is characterized by adjusting the mole ratio of the soft segment polyamine monomer with respect to the total of the soft segment polyamine monomer and the hard segment polyamine monomer to 0.4-0.95.

IPC Classes  ?

• C08G 71/04 - Polyurethanes

Abstract

In the present invention, at least one of the genes (A) and (B) mentioned below is disrupted in a transformed microorganism belonging to the genus Cupriavidus.　Gene (A): a gene that encodes 2-hydroxy-acid dehydrogenase comprising an amino acid sequence represented by any one of SEQ ID NOs: 1 to 4, or a gene that encodes a protein which comprises an amino acid sequence having 90% or higher sequence identity to an amino acid sequence represented by any one of SEQ ID NOs: 1 to 4 and which has a 2-hydroxy-acid dehydrogenase activity. Gene (B): a gene that encodes a regulator protein which regulates the expression of at least one of the genes included in gene (A).

IPC Classes  ?

• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C08G 63/78 - Preparation processes
• C12N 15/09 - Recombinant DNA-technology
• C12N 15/53 - Oxidoreductases (1)
• C12P 7/52 - Propionic acidButyric acids
• C12P 7/56 - Lactic acid
• C12P 7/625 - Polyesters of hydroxy carboxylic acids

Abstract

[Problem] To provide a separation membrane capable of efficiently removing a substance (such as an ionic substance) in liquid, the separation membrane comprising an octosilicate material. To provide a molded article of a separation membrane for a substance in liquid, the molded article having high chemical resistance due to a separation membrane component, having high solvent permeability rate of the membrane for an organic solution containing a substance to be separated and capable of efficiently separating a substance (such as an ionic organic substance) in an organic liquid. [Solution] A composition for formation of a separation membrane for a substance in liquid, comprising component (A): a nitrogen-containing basic compound (A) that is a tertiary amine or a quaternary ammonium hydroxide having one or more alkyl groups with three or four carbon atoms, component (C): delamination particles (C) of a protonated layered polysilicate compound (B) and component (D): a solvent. A molded article of a separation membrane for a substance in liquid, comprising delamination particles (C) and a substrate (E) supporting the separation membrane for a substance in liquid.

IPC Classes  ?

• B01D 71/02 - Inorganic material
• B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/06 - Organic material
• B01D 71/10 - CelluloseModified cellulose
• B01D 71/14 - Esters of organic acids
• B01D 71/30 - Polyalkenyl halides
• B01D 71/34 - Polyvinylidene fluoride
• B01D 71/38 - PolyalkenylalcoholsPolyalkenylestersPolyalkenylethersPolyalkenylaldehydesPolyalkenylketonesPolyalkenylacetalsPolyalkenylketals
• B01D 71/40 - Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
• B01D 71/68 - PolysulfonesPolyethersulfones
• C01B 33/20 - Silicates

Abstract

Provided is a wastewater concentration device comprising: reverse osmosis membrane devices 5 and 8 to which wastewater is supplied; a pressure recovery device 20 that recovers pressure from concentrated water supplied from the reverse osmosis membrane devices; and osmotic pressure-assisted reverse osmosis membrane devices 31, 33, 33, and 35 through which the concentrated water that has passed through the pressure recovery device flows.

IPC Classes  ?

• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 61/06 - Energy recovery
• B01D 61/58 - Multistep processes
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis

Abstract

An anti-SIRPα antibody that can be used as a tumor agent and an anti-tumor agent comprising the antibody as an active ingredient. An antibody that binds specifically to human SIRPα to inhibit binding of human SIRPα to CD47.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes

Abstract

An object of the present invention is to provide a method for easily and efficiently evaluating the ability of test samples to trigger a foreign body reaction in the skin without using animals, a substance having an ability to inhibit a foreign body reaction in the skin, and a screening method for obtaining the substance. The above objects are attained by providing a method for evaluating an ability of a test sample to trigger a foreign body reaction in the skin, comprising: (1) a step of making a solution containing said test sample in contact with a keratinocyte transformed by a reporter vector comprising an enhancer sequence comprising a xenobiotic responsive element (XRE) and a reporter sequence encoding a reporter protein at downstream of said enhancer sequence, (2) a step of measuring an expression level of said reporter protein in said keratinocyte, and (3) a step of evaluating an ability of said test sample to trigger a foreign body reaction in the skin based on the measured expression level of said reporter protein; a method for screening a substance having an ability to inhibit a foreign body reaction in the skin using the evaluation method; and an agent for inhibiting a foreign body reaction in the skin comprising Fraglide-1, which was found using the screening method.

IPC Classes  ?

• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61K 31/365 - Lactones
• A61Q 19/08 - Anti-ageing preparations

Abstract

In one embodiment, the object of the present invention is to provide a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, and a method for reducing nephrotoxicity of the pharmaceutical composition. In one embodiment, the present invention relates to a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, wherein the nephrotoxicity reducing agent comprises a sugar alcohol and is used in an amount such that the concentration of the sugar alcohol in the pharmaceutical composition is 1 mg/ml to 400 mg/mL.

IPC Classes  ?

• A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
• A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
• A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Provided is a reagent which uses a novel combination of minimal residual disease (MRD) markers for neuroblastoma and which can improve the accuracy of evaluating the minimal residual disease of neuroblastoma. The reagent according to the present invention includes a primer pair capable of amplifying, by a nucleic acid amplification technique, the following: minimal residual disease genetic markers for neuroblastoma, comprising B4GALNT1, CHRNA3, CRMP1, DBH, PHOX2B, and TH; and a reference gene comprising HPRT1 and HMBS. The reagent is to be used for evaluating the minimal residual disease of neuroblastoma, and can improve the accuracy of evaluating the minimal residual disease of neuroblastoma.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12Q 1/686 - Polymerase chain reaction [PCR]

Abstract

The present invention provides a new separation function layer that is suited for separating an acidic gas from a gas mixture that includes the acidic gas. A separation function layer 1 according to the present invention comprises: an ionic liquid L; a hydrophilic polymer A that forms a crystal structure in the ionic liquid L; and a polymer B that is different from the polymer A. A separation membrane 10 according to the present invention comprises: the separation function layer 1; and a porous support 3 that supports the separation function layer 1.

IPC Classes  ?

• B01D 71/06 - Organic material
• B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor
• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/38 - PolyalkenylalcoholsPolyalkenylestersPolyalkenylethersPolyalkenylaldehydesPolyalkenylketonesPolyalkenylacetalsPolyalkenylketals
• B01D 71/44 - Polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds, not provided for in a single one of groups
• C08L 29/04 - Polyvinyl alcoholPartially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• C08L 39/06 - Homopolymers or copolymers of N-vinyl-pyrrolidones

Abstract

The purpose of the present invention is to provide a method for efficiently producing a high-quality reticulated polyurethane without using any isocyanate. The method for producing a reticulated polyurethane according to the present invention is characterized by including a step in which a fluorinated biscarbamate compound represented by formula (I) is reacted with a polyol compound represented by formula (II). [In the formulae, Rf11-61-6 fluoroalkyl group, Rf2represents a fluorinated divalent organic group, R1represents an n-valent organic group, R2 represents a divalent organic group, and n is an integer of 3-8.]

IPC Classes  ?

• C08G 18/80 - Masked polyisocyanates
• C08G 71/04 - Polyurethanes

Abstract

A variable capacitance capacitor (1) comprises: a first electrode layer (11); an insulating layer (31) disposed on the first electrode layer; a second electrode layer (21) disposed in a first region (RG1) on the insulating layer; a third electrode layer (22) disposed in a second region (RG2) separated from the first region on the insulating layer; a dielectric layer (32) disposed in a third region (RG3) at least between the first and second regions on the insulating layer; and a fourth electrode layer (12) disposed on the dielectric layer.

IPC Classes  ?

• H01G 7/06 - Capacitors in which the capacitance is varied by non-mechanical meansProcesses of their manufacture having a dielectric selected for the variation of its permitivity with applied voltage, i.e. ferroelectric capacitors
• H01G 4/30 - Stacked capacitors
• H01G 4/33 - Thin- or thick-film capacitors

Abstract

The present invention provides a complex containing a nucleic acid sequence-recognizing module and a proteolysis tag, wherein the module is linked to the proteolysis tag, the module specifically binds to a target nucleotide sequence in a double stranded DNA, and the tag consists of (i) a peptide containing 3 hydrophobic amino acid residues at the C-terminal, or (ii) a peptide containing 3 amino acid residues at the C-terminal wherein at least a part of the amino acid residues is substituted by serine

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/22 - Ribonucleases
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

The invention provides a method for producing a plant cell modified at a targeted site of a double-stranded DNA, including (i) a step of providing a plant cell comprising the double-stranded DNA of interest, (ii) a step of providing a complex in which a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in the double-stranded DNA and a DNA glycosylase with sufficiently low reactivity with the double-stranded DNA are bound, (iii) a step of placing the complex in a condition under which the plant cell is transfected, (iv) a step of placing the transfected plant cell in a condition that induces modification of the targeted site, without cleaving at least one strand of the double-stranded DNA in the targeted site, and (v) a step of selecting a cell into which the complex has been introduced and/or a cell into which the modification has been introduced.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 9/22 - Ribonucleases

Abstract

A method of inhibiting the function of myostatin is provided. A method of inhibiting the function of myostatin is provided. An antisense oligonucleotide of 15-30 bases or a salt or a solvate thereof, wherein the antisense oligonucleotide has a nucleotide sequence complementary to a target sequence in exon 3 of the myostatin gene and is capable of allowing the expression of a splicing variant of myostatin. A pharmaceutical drug, a food, a feed, an agent for promoting myocyte proliferation and/or hypertrophy, an agent for increasing muscle mass and/or suppressing muscle weakness, an agent for switching the splicing of the myostatin gene from production of myostatin to production of a splicing variant thereof, an agent for decreasing myostatin signaling, and an anticancer agent, each of which comprises the above antisense oligonucleotide or a salt or a solvate thereof.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A23K 20/153 - Nucleic acidsHydrolysis products or derivatives thereof
• A23L 33/13 - Nucleic acids or derivatives thereof
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

A therapeutic agent for hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) contains as an active ingredient a substance repairing c.854C>T mutation to C in TFG gene having c.854C>T and c.846T>C mutations. This substance may contain DNA that is transcribed in mammalian cells and a transduction medium introducing the DNA into the mammalian cells.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 35/76 - VirusesSubviral particlesBacteriophages
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

A reaction of a fluid in a reaction chamber is satisfactorily performed. A reaction of a fluid in a reaction chamber is satisfactorily performed. A fluid control method includes: generating, in a reaction chamber (84) formed between an outer cylinder (61) and an inner cylinder (70) coaxially disposed in the outer cylinder (61), a reaction phase (30) having a ring shape and formed of a reaction target fluid (F1, F2) in which a Taylor vortex (V1) is generated, the reaction phases (30) arranged in an axis (R) direction, and an inhibiting phase (31) having a ring shape that is adjacent to the reaction phase (30) in the axis (R) direction and inhibits the reaction target fluid (F1, F2) in the reaction phase (30) from flowing out to an outside of the reaction phase (30).

IPC Classes  ?

• B01J 19/18 - Stationary reactors having moving elements inside
• B01F 27/272 - Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces

Abstract

The spirosolane skeleton 23-position hydroxylase gene and the spirosolane skeleton 23-position acetyltransferase gene derived from S. chacoense, S. tuberosum, and S. lycopersicum are found to be involved with the biosynthesis of leptine, which achieves resistance against Colorado potato beetle.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• A01H 1/00 - Processes for modifying genotypes
• A01H 6/82 - Solanaceae, e.g. pepper, tobacco, potato, tomato or eggplant
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

The purpose of the present invention is to provide a method for safely and efficiently producing a carbonyl halide. A method for producing a carbonyl halide according to the present invention is characterized by including a step for irradiating, in the presence of oxygen and ozone, a halomethane having one or more halogeno groups selected from the group consisting of chloro, bromo and iodo with light.

IPC Classes  ?

• C01B 32/80 - Phosgene
• C07C 68/02 - Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
• C07C 69/96 - Esters of carbonic or haloformic acids
• C07C 263/10 - Preparation of derivatives of isocyanic acid by reaction of amines with carbonyl halides, e.g. with phosgene
• C07C 265/04 - Derivatives of isocyanic acid having isocyanate groups bound to acyclic carbon atoms of a saturated carbon skeleton

Abstract

The purpose of the present invention is to provide an antibody against pancreatic cancer stem cells. This antibody against pancreatic cancer stem cells includes a heavy chain variable region including heavy chain CDRs described as HCDR1-HCDR3, and a light chain variable region including light chain CDRs described as LCDR1-LCDR3, and has an ability to bind to pancreatic cancer stem cells, where HCDR1 has an amino acid sequence located at positions 26-35 in SEQ ID NO: 1 or a sequence analogous thereto, HCDR2 has a sequence located at positions 47-65 in SEQ ID NO: 1 or a sequence analogous thereto, HCDR3 has a sequence located at positions 96-104 in SEQ ID NO: 1 or a sequence analogous thereto, LCDR1 has a sequence located at positions 24-34 in SEQ ID NO: 2 or a sequence analogous thereto, LCDR2 has a sequence located at positions 46-56 in SEQ ID NO: 2 or a sequence analogous thereto, and LCDR3 has a sequence located at positions 89-96 in SEQ ID NO: 2 or a sequence analogous thereto.

IPC Classes  ?

• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• A61P 35/00 - Antineoplastic agents
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

Provided are: a biological tissue retraction device capable of low invasive retraction of a biological tissue such as an organ while suppressing damage thereto and the like and of easily securing the surgical field; and a biological tissue retraction method using said biological tissue retraction device. This biological tissue retraction device for retracting a biological tissue to be retracted is provided with adhesion plates (2) formed from a material that is capable of adhering to a biological tissue by being brought into abutment thereagainst, and a holding member (3) that extends in one direction and holds a pair of the adhesion plates (2) on the two ends thereof in the extension direction, one of the pair of adhesion plates (2) being adhered to the biological tissue to be retracted and the other being adhered to a different biological tissue from the biological tissue to be retracted so as to maintain the retracted state of said biological tissue.

IPC Classes  ?

• A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors

Abstract

A processor includes an instruction decoder configured to decode an instruction including bypass information and generate a bypass control signal based on the bypass information; a data holding circuit configured to hold data to be used to execute the instruction; an arithmetic circuit configured to execute the instruction and output operation result data; and a first selector configured to select the data held in the data holding circuit or the operation result data based on the bypass control signal and output the selected data or the selected operation result data to the arithmetic circuit.

IPC Classes  ?

• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead

Abstract

A processor includes an arithmetic circuit configured to execute an arithmetic instruction; and a register configured to hold data used by the arithmetic circuit. The processor receives a data movement instruction and the arithmetic instruction corresponding to the data movement instruction, and moves the data from a first memory to the register based on a data movement instruction. The arithmetic circuit executes the arithmetic instruction after a data movement of the data movement instruction is completed.

IPC Classes  ?

• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode

Abstract

An operation circuit includes a plurality of multipliers each configured to multiply each of respective first mantissas of a plurality of first data to which a first common exponent is set as a common exponent, by each of respective second mantissas of a plurality of second data to which a second common exponent is set as a common exponent; and a first adder configured to add up a plurality of products calculated by the plurality of multipliers.

IPC Classes  ?

• G06F 7/544 - Methods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using non-contact-making devices, e.g. tube, solid state deviceMethods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using unspecified devices for evaluating functions by calculation
• G06F 5/01 - Methods or arrangements for data conversion without changing the order or content of the data handled for shifting, e.g. justifying, scaling, normalising
• G06F 7/485 - AddingSubtracting
• G06F 7/487 - MultiplyingDividing

Abstract

The disclosure provides for agents, compositions of the agent for the use in treating cancer by contacting a cancer cell with an agent to increase the tension of a plasma membrane of the cancer cell, thereby preventing or reducing cell migration and/or proliferation of the cancer cell and treating the cancer.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 38/45 - Transferases (2)
• A61K 38/46 - Hydrolases (3)
• A61K 47/02 - Inorganic compounds
• A61K 47/06 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

Abstract

Provided is a technology that can provide an excellent suppressive effect against adhesion of calculi or calcification in a medical device to be retained within the body. This agent for suppressing calculi adhesion or calcification contains polydopamine and/or a derivative thereof, and is used to form at least an outermost surface of a coating layer of a medical device to be retained within a urinary organ or a circulatory organ.

IPC Classes  ?

• A61L 27/34 - Macromolecular materials
• A61L 27/50 - Materials characterised by their function or physical properties
• A61L 29/08 - Materials for coatings
• A61L 31/10 - Macromolecular materials

Abstract

The present disclosure pertains to a remote operation device that remotely operates a movable body on the basis of operation information from an operator, the remote operation device comprising: a first reception unit that receives, via a transmission path, a first wave variable that is obtained by performing wave variable transformation of the state amount of the movable body and that is output from a movable-body control device that outputs a movable-body control amount for controlling the movable body; a first wave variable transformation unit that performs wave variable transformation of the first wave variable and an operation amount based on the operation information and that outputs the same respectively as a post-transformation state amount and a second wave variable; and a first transmission unit that transmits, via the transmission path, the second wave variable to the movable-body control device.

IPC Classes  ?

• H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom

Abstract

This wastewater concentration device and method comprise: an osmotically assisted reverse osmosis device that has a primary chamber and a secondary chamber which are separated by an osmotically assisted reverse osmosis membrane and that performs an osmotically assisted reverse osmosis method; and a water supply means for supplying to-be-treated water to the primary chamber. The water supply means uses a cation exchange device or an anion exchange device to treat at least a portion of the to-be-treated water so that the pH of the to-be-treated water to be supplied to the osmotically assisted reverse osmosis device ranges from a first prescribed pH to a second prescribed pH (where the first prescribed pH is an alkaline pH, and the second prescribed pH is the pH of an acidic pH).

IPC Classes  ?

• B01D 61/10 - AccessoriesAuxiliary operations
• B01D 71/16 - Cellulose acetate
• C02F 1/42 - Treatment of water, waste water, or sewage by ion-exchange
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis

Abstract

Provided is a method for altering a targeted site of a DNA in a cell, including a step of stimulating the cell with a factor inducing a DNA modifying enzyme endogenous to the cell, and bringing a complex of a nucleic acid sequence-recognizing module specifically binding to a target nucleotide sequence in a given DNA and a DNA modifying enzyme-binding module bonded to each other into contact with the DNA to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

Provided is a super-high-molecular gamma-polyglutamic acid having an average molecular weight of at least 20 million. Also provided is a Bacillus genus bacterium variant strain that can produce said super-high-molecular γ-PGA. Further provided is a method for screening for said Bacillus genus bacterium variant strain that can produce said super-high-molecular γ-PGA. The present invention produces Bacillus genus bacterium variant strain, and produces a gamma-polyglutamic acid having an average molecular weight of at least 20 million.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C12N 15/01 - Preparation of mutants without inserting foreign genetic material thereinScreening processes therefor
• C12N 15/31 - Genes encoding microbial proteins, e.g. enterotoxins
• C07K 14/32 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Bacillus (G)

Abstract

Provided is a γδT cell for securing the purity and number of cells sufficient for treatment. Also provided is a method of generating the γδT cell. More specifically, provided are homogeneous γδT cells excellent in that the γδT cells are not affected by exhaustion of the cells. The foregoing is achieved by γδT cells obtained by subjecting induced pluripotent stem cells (iPS cells) to differentiation induction treatment. Specifically, the foregoing is achieved by γδT cells generated by subjecting iPS cells having a rearranged γδTCR gene (γδTCR-type iPS cells) to differentiation induction treatment. According to the method of generating the γδT cell of the present invention, there can be provided γδT cells and a cell population of γδT cells that have an excellent function of having antigen-specific cytotoxic activity in a MHC-unrestricted manner, and that are more homogeneous and have a higher effect than γδT cells separated from peripheral blood.

IPC Classes  ?

• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• C07K 14/725 - T-cell receptors
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

This transformed microorganism of a microorganism belonging to the genus Cupriavidus, which has the ability to produce a copolyester of 3-hydroxybutyric acid and another hydroxyalkanoic acid, has: a gene encoding a copolyester synthase; and a foreign gene having an amino acid sequence represented by any of SEQ ID NOs: 2-6 and encoding propionyl CoA transferase or butyl CoA transferase, and/or a foreign gene having at least 90% sequence identity to an amino acid sequence represented by any of SEQ ID Nos: 2-6, and encoding a protein having propionyl CoA transferase activity or butyl CoA transferase activity.

IPC Classes  ?

• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 15/54 - Transferases (2)
• C12N 15/55 - Hydrolases (3)
• C12P 7/625 - Polyesters of hydroxy carboxylic acids

Abstract

The invention provides a site-specific modification method of a DNA molecule that enables gene function manipulation. In particular, the invention provides a method for manipulating gene function by a site-specific action on a target DNA molecule, said method comprising a step for preparing a complex containing an Argonaute protein, a guide RNA and an additional sequence and a step for contacting the target DNA molecule with the complex, wherein the guide RNA is designed to guide the complex to a region containing the desired site in the target DNA molecule.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

Provided is an orally administrable vaccine against a coronavirus infectious disease. A transformed Bifidobacterium designed to display a part or a whole of a constituent protein of a coronavirus on a surface of the Bifidobacterium enables the provision of the orally administrable vaccine against a coronavirus infectious disease. The transformed Bifidobacterium designed to display a part or a whole of a constituent protein of a coronavirus on a surface of the Bifidobacterium can induce humoral immunity and cellular immunity through oral administration to suppress an increase in severity of pneumonia or the like even after viral infection.

IPC Classes  ?

• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61P 31/14 - Antivirals for RNA viruses
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses

Abstract

Provided is a method capable of shortening the time required for analysis and capable of analyzing various substances produced by microorganisms. A method for analyzing a metabolite of a microorganism according to the present invention includes: a step of supplying a mobile phase including carbon dioxide in a liquid state, a subcritical state, or a supercritical state to a container in which a microorganism cultured in a medium is contained together with the medium, to move a component of a metabolite of the microorganism present in the microorganism and the medium to the mobile phase; a step of introducing a mobile phase to which a component of the metabolite has moved into a column; and a step of performing mass spectrometry on a component of the metabolite contained in the mobile phase that has passed through the column.

IPC Classes  ?

• G01N 30/72 - Mass spectrometers
• C12N 1/20 - BacteriaCulture media therefor
• G01N 30/04 - Preparation or injection of sample to be analysed
• G01N 30/26 - Conditioning of the fluid carrierFlow patterns

Abstract

Expression of matrix metalloproteinase 1 is suppressed. A matrix metalloproteinase 1 expression suppression agent of this disclosure contains, as an active ingredient, at least one selected from the group consisting of Saxifraga sarmentosa, an extract of Saxifraga sarmentosa, rosemary, an extract of rosemary, licorice, an extract of licorice, Melissa officinalis, an extract of Melissa officinalis, wild thyme, an extract of wild thyme, hop, and an extract of hop.

IPC Classes  ?

• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 36/484 - Glycyrrhiza (licorice)
• A61K 36/53 - Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• A61K 36/537 - Salvia (sage)

Abstract

A composition for fluorescent labeling according to the present invention comprises: a compound (A) which is an ICG compound; and a hydroxyl group-containing organic compound (B). This makes it possible to provide, for example, a composition for fluorescent labeling which has excellent compartment identifiability that allows an observation target to be more accurately identified, which has a long light emission time and thus makes it possible to observe the observation target for a long time, and which also reduces a burden on a living body and is excellent in economical efficiency.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• A61M 5/28 - Syringe ampoules or cartridges, i.e. ampoules or cartridges provided with a needle
• A61K 49/00 - Preparations for testing in vivo
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

A federated learning system in which a plurality of local servers repeatedly learn cooperatively through communications between the plurality of local servers and a central server via a network. The local server includes a decryption unit, a mean gradient calculation unit, a model updating unit, a validation error calculation unit, an encryption unit, and a local transmission unit that transmits at least one of a current local mean gradient and a current local validation error. The central server includes a central reception unit, a model selection unit, a weight determination unit, and a central transmission unit. The central reception unit receives encrypted current local models and at least one of current local training data counts, the current local mean gradients, and the current local validation errors from the plurality of respective local servers.

IPC Classes  ?

• G06N 3/098 - Distributed learning, e.g. federated learning

Abstract

The purpose of the present invention is to provide a novel affective disorder ameliorating agent. A PKCγ activity inhibitor is useful as an active ingredient for an affective disorder ameliorating agent.

IPC Classes  ?

• A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61P 25/18 - Antipsychotics, i.e. neurolepticsDrugs for mania or schizophrenia
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

The purpose of the present invention is to provide an esophagus-cooling agent capable of cooling the esophagus by a simple and easy means with a relatively small burden on a patient. The present invention pertains to an esophagus-cooling agent comprising a solvent and a compound (A). At least a portion of the compound (A) is a non-dissolved material that is not dissolved in the solvent when the esophagus-cooling agent is at 25°C. When differential scanning calorimetry (DSC) is performed on the esophagus-cooling agent in accordance with JIS K7122-2012, an endothermic signal that has a negative DDSC (value obtained by differentiating a heat flow by temperature) in a region where the temperature is in the range of 10-50°C and where the heat flow is at most 0 (W/g) can be observed, and the dynamic viscosity at 25°C is 100-5,000 mm2/s.

IPC Classes  ?

• A61L 31/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 31/14 - Materials characterised by their function or physical properties
• A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

The present disclosure pertains to creation of a new NRPS. In the present disclosure, introduction of a restriction enzyme recognition sequence to a nucleic acid encoding an NRPS while maintaining the function of producing a target NRP was successful. By using the introduced restriction enzyme recognition sequence, it is possible to create various NRPSs. In one aspect, the present disclosure provides a nucleic acid that encodes an NRPS and that includes a non-native restriction enzyme recognition sequence. In another aspect, the present disclosure provides a method for efficiently creating a nucleic acid the encodes a new NRPS, by using a non-native restriction enzyme recognition sequence. The present disclosure also provides a new NRPS and a new NRP.

IPC Classes  ?

• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Abstract

The present invention relates to an improved technology for a device that identifies and diagnoses an environmental stress state of plants. An environmental stress diagnosis device comprises a measurement light source 12, an induction light source 14, and a transmitted light detector 18. The measurement light source 12 radiates a first measurement light ML1 and a second measurement light ML2 to a plant sample S, the induction light source 14 radiates a first photosynthesis inducing light FR and a second photosynthesis inducing light AL to the plant sample S, and the transmitted light detector 18 detects a first transmitted light TL1 and a second transmitted light TL2. The control unit 20 has an analysis circuit 20a and a control circuit 20b. The analysis circuit 20a calculates a light absorption difference between the first transmitted light TL1 and the second transmitted light TL2, and calculates Y(ND) which is a state in which P700 in photosystem I in photosynthesis has been oxidized as a ROS marker (a reactive oxygen species suppression index) for plants by utilizing the light absorption difference. The analysis circuit 20a diagnoses an environmental stress state of plants by utilizing the ROS marker.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 21/84 - Systems specially adapted for particular applications
• G01N 27/403 - Cells and electrode assemblies

Abstract

The objective of the present invention is to guide a mobile body to an appropriate position. This route setting method includes: a step for detecting, by means of a terminal having a movable position, position information of an object in a terminal coordinate system serving as a reference for detection performed by the terminal; a step for performing coordinate conversion between the terminal coordinate system and a mobile body coordinate system serving as a reference for movement of the mobile body, to calculate first position information indicating a position of the object in the mobile body coordinate system from the position information of the object in the terminal coordinate system; and a step for setting a route toward the object, in the mobile body coordinate system, on the basis of the first position information.

IPC Classes  ?

• G05D 1/02 - Control of position or course in two dimensions

Abstract

The present invention provides a method which is capable of producing polyimide hollow particles, the method being capable of producing polyimide hollow particles having excellent heat resistance without requiring use of template particles and without requiring high temperature and high pressure. The present invention also provides polyimide hollow particles which are produced by this production method.　A method for producing polyimide hollow particles according to one embodiment of the present invention produces polyimide hollow particles, each of which has a shell part and a hollow portion that is surrounded by the shell part. This method for producing polyimide hollow particles comprises: a step for preparing an internal oil phase that contains polyamic acid fine particles and a solvent; a step for preparing an external oil phase which contains a hydrocarbon-based solvent and at least one substance that is selected from the group consisting of silicon dioxide and a compound having a siloxane bond; and a step for performing a chemical imidization reaction in an emulsion that has been prepared from the internal oil phase and the external oil phase.

IPC Classes  ?

• C08J 3/16 - Powdering or granulating by coagulating dispersions
• B01J 13/02 - Making microcapsules or microballoons
• C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
• C08J 3/09 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in organic liquids
• C08J 9/28 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum

Abstract

A method and a device are provided for measuring a zeta potential with reproducibility, high reliability and high accuracy, by predicting an equilibrium value from the change over time of a streaming potential. In measurement of the zeta potential of a sample surface using a streaming potential method, an external pressure is changed in a step-wise manner, and a pressure change profile is set having a rising part or a falling part which is of a shorter time than the relaxation time T required for response to a change in the streaming potential accompanying the change in external pressure, and a steady part in which pressure is held at a steady state for a time longer than the relaxation time T. An asymptotic value of the streaming potential extrapolated from the transient response of the streaming potential occurring from the pressure change profile is used to calculate the zeta potential.

IPC Classes  ?

• G01N 27/60 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrostatic variables

Abstract

The present invention relates to an improved technology for a device that identifies and diagnoses an environmental stress state of plants. A control circuit 20b controls a measurement light source 12 such that a second measurement light ML2 has higher power than a first measurement light ML1 and the first measurement light ML1 and the second measurement light ML2 become opposite-phase rectangular waves, and further controls the measurement light source 12 such that the first measurement light ML1 and the second measurement light ML2 are output in synchronization to form the first measurement light ML1 and the second measurement light ML2 into a quasi-single composite rectangular wave measurement light ML3 of 5 kHz to 30 kHz. A transmitted light detector 18 detects the composite rectangular wave measurement light ML3 transmitted through a plant sample S as a composite rectangular wave transmitted light TL. An analysis circuit 20a calculates a light absorption difference by utilizing the composite rectangular wave transmitted light TL, and calculates Y(ND) which is an oxidized state of P700 as a ROS marker utilizing the light absorption difference, and diagnoses an environmental stress state of plants by utilizing the ROS marker.

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01N 21/84 - Systems specially adapted for particular applications
• A01G 7/04 - Electric or magnetic treatment of plants for promoting growth

Abstract

Provided is a heat regeneration system in which a heat source necessary for a process is regenerated with a waste heat. This heat regeneration system utilizes a hot waste heat and a cold waste heat discharged from a process to convert the hot waste heat and the cold waste heat respectively into a necessary high-temperature heat and a necessary low-temperature heat. This heat regeneration system is provided with: (a) a thermal amplifier 4 in which an adsorbent that utilizes a hot waste heat as an adsorption heat is stored; (b) a thermal battery 5 in which a latent heat storage material capable of storing an output heat from the thermal amplifier is stored; (c) a thermal transistor 2 in which evaporated water in a high-pressure absorber is absorbed in the absorption solution, a temperature-risen heat is extracted with a heat exchanger and is output as a high-temperature heat, water is evaporated with a low-pressure evaporator, a cold waste heat discharged from a low-temperature process 7 by the action of a steam latent heat is cooled to output a low-temperature heat, and the absorption solution is regenerated using a latent heat of the latent heat storage material; and (d) a thermal booster 3 in which the temperature of the high-temperature heat is risen by a hydration reaction of a chemical heat storage material, a heat is stored by a dehydration reaction of the chemical heat storage material using the high-temperature heat, steam generated by the dehydration reaction is condensed using the low-temperature heat to promote the regeneration of the chemical heat storage material, and a heat source necessary for the process is produced.

IPC Classes  ?

• F25B 25/00 - Machines, plants or systems, using a combination of modes of operation covered by two or more of the groups
• F25B 27/02 - Machines, plants or systems, using particular sources of energy using waste heat, e.g. from internal-combustion engines

Abstract

Provided are an oral muscle training instrument and an oral muscle training method, whereby it becomes possible to effectively stimulate a genioglossus muscle that is a deep muscle in the oral cavity. The oral muscle training instrument is provided with: a pair of electrodes that are arranged in the oral cavity; an electrode that is branched from one of the pair of electrodes and is arranged on the surface of the skin; and an electric circuit that distributes a medium frequency current between the electrodes. The pair of electrodes are placed on the tongue, and the electrode arranged on the surface of the skin is placed below the chin or in the front of the neck. It is possible that the pair of electrodes is placed on the tongue and the electrode arranged on the surface of the skin is placed on approximately the entire circumference of the neck. The medium frequency current is such a burst wave current that a procedure including continuously distributing a continuous wave current of 3 kHz or more and less than 8 kHz or a current of 3 kHz or more and less than 8 kHz for a predetermined time and subsequently halting the distribution of the current for a predetermined time is repeated.

IPC Classes  ?

• A61N 1/32 - Applying electric currents by contact electrodes alternating or intermittent currents
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

The objective of the present invention is to provide a method for producing a carbonyl halide efficiently to the used halogenated hydrocarbon. The method for producing a carbonyl halide according to the present invention is characterized in comprising the steps of preparing a mixed gas comprising oxygen and a C2-4 halogenated hydrocarbon having one or more halogeno groups selected from the group consisting of chloro, bromo and iodo, and flowing the mixed gas and irradiating a high energy light to the flowed mixed gas.

IPC Classes  ?

• C07C 51/58 - Preparation of carboxylic acid halides

Abstract

The present disclosure provides a biosensor having improved sensitivity. The present disclosure also provides a base material for manufacturing a sensor for analyzing a detection object, said base material comprising a molecularly imprinted polymer having: a molecularly imprinted recess in which a target of the detection object is received; and a group for binding a specific bondable molecule to the target, said group being provided inside the molecularly imprinted recess. The base material is characterized in that the group for binding the specific bondable molecule is a group suited for a small substance, and/or is characterized in that the molecularly imprinted recess has a shape or structure suited for a small substance.

IPC Classes  ?

• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/545 - Synthetic resin

Abstract

A virus inactivation method is provided. The method includes irradiating a solution containing an artificially expressed antibody or antibody fragment with ultraviolet rays in the presence of a radical scavenger. The irradiating only aggregates 5% or less of the antibody or antibody fragment. A wavelength of the ultraviolet rays is 200 nm or longer and 315 nm or shorter. An irradiation amount of the ultraviolet rays is 300 mJ/cm2 or more. An irradiation time of the ultraviolet rays is 3 minutes or less. A concentration of the radical scavenger in the solution is 0.03 mM or more.

IPC Classes  ?

• A61K 41/17 - Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
• C12M 1/00 - Apparatus for enzymology or microbiology
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Abstract

The objective of the present invention is to provide a method for producing a carbonyl halide efficiently to the used halogenated methane. The method for producing a carbonyl halide according to the present invention is characterized in comprising the steps of preparing a mixed gas comprising oxygen and a halogenated methane having one or more halogeno groups selected from the group consisting of chloro, bromo and iodo, and flowing the mixed gas and irradiating a high energy light to the flowed mixed gas.

IPC Classes  ?

• C01B 32/80 - Phosgene

Abstract

An object of the present invention is to provide a polyamide porous membrane having improved fluid permeation performance. A polyamide porous membrane having a dense layer formed on at least one surface, wherein the polyamide porous membrane has a streak-like recessed portion extending in one direction of a surface of the dense layer, and the streak-like recessed portion has an orientation angle of 0 to 5.0° or 175.0 to 180.0° and an orientation intensity of 1.5 to 2.0 according to predetermined orientation analysis.

IPC Classes  ?

• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 71/56 - Polyamides, e.g. polyester-amides
• B01D 69/08 - Hollow fibre membranes
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus

Abstract

Provided is a medical immobilization device that contributes to reducing the burden on a patient, while being capable of firmly immobilizing the patient. A medical immobilization device 10 is a device for immobilizing a specific site 1 of the body of a patient with the patient lying on their back. The medical immobilization device 10 comprises a block 3 made of a material that allows radiation to pass through, and the block 3 comprises holder portions 2a to 2c in which at least a region from the lower surface to both sides of the specific site 1 fit. All or part of the upper part of the block 3 is open.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

An object of the present invention is to provide a nanofiltration membrane having a molecular weight cut-off of 200 to 1,000 and a high amount pf permeate for methanol, and suitable for use as an organic solvent nanofiltration membrane. A nanofiltration membrane formed using a polyamide resin, the nanofiltration membrane having a molecular weight cut-off of 200 to 1,000 and a methanol permeability of 0.03 L/(m2·bar·h) or more.

IPC Classes  ?

• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 71/56 - Polyamides, e.g. polyester-amides
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 69/08 - Hollow fibre membranes
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• C07C 29/76 - SeparationPurificationStabilisationUse of additives by physical treatment

Abstract

The invention provides a miniaturized cytidine deaminase-containing complex for modifying DNA formed by combining a nucleic acid sequence recognition module and cytidine deaminase, wherein the nucleic acid sequence recognition module specifically binds to a target nucleotide sequence of double-stranded DNA, the cytidine deaminase is composed of an amino acid sequence composed of a region of amino acid residues at positions 30-150 of SEQ ID NO: 1, an ortholog thereof, an amino acid sequence having mutations of one or several amino acids therein, or an amino acid sequence having at least 90% similarity thereto, and the targeted site of the double-stranded DNA is modified.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• C12N 15/86 - Viral vectors
• C12N 9/22 - Ribonucleases

Abstract

The present invention provides: a filtration membrane (particularly, a hollow fiber membrane-type filtration membrane) which effectively inhibits fouling, which has excellent recovery of water permeability after cleaning when fouling has occurred, and which has water resistance; and method for producing said membrane.　The present disclosure was achieved upon finding a method for producing a filtration membrane (particularly, a hollow fiber membrane-type filtration membrane) wherein: a filtration membrane is produced with a membrane-forming stock solution that contains a polymer which contains vinylidene fluoride as a monomer and an outside control solution that contains a polymer which contains styrene and maleic anhydride as monomers; and immobilizing on the filtration membrane a polymer that contains a specific phosphorylcholine group.

IPC Classes  ?

• B01D 71/28 - Polymers of vinyl aromatic compounds
• B01D 71/34 - Polyvinylidene fluoride
• B01D 71/40 - Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters

Abstract

[Problem] To provide: a device and a method that are for producing a plasma functional liquid and that are capable of producing preferable cleaning effect and disinfection effect even when plasma gas is introduced into a liquid by means of bubbling; and a horticultural plant. [Solution] A plasma functional liquid production device 10 comprises: a plasma head 20 which generates a plasma gas containing an active species from a plasma generation gas; a plasma gas releasing part 30 which releases the plasma gas in the form of gas bubbles; and a plasma functional liquid generation part 40 which is equipped with a plasma functional liquid generation tank 41 that retains a solvent S and which generates a plasma functional liquid L by introducing the plasma gas in the form of gas bubbles into the solvent S. The plasma generation gas has an oxygen concentration of 90% or more.

IPC Classes  ?

• A01N 59/00 - Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• A01G 31/00 - Soilless cultivation, e.g. hydroponics
• A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
• A01P 3/00 - Fungicides
• A01P 21/00 - Plant growth regulators
• B01F 23/231 - Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids by bubbling
• B01F 23/2373 - Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media for obtaining fine bubbles, i.e. bubbles with a size below 100 µm
• B01F 23/2375 - Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media for obtaining fine bubbles, i.e. bubbles with a size below 100 µm for obtaining bubbles with a size below 1 µm
• B01F 25/21 - Jet mixers, i.e. mixers using high-speed fluid streams with submerged injectors, e.g. nozzles, for injecting high-pressure jets into a large volume or into mixing chambers
• B01F 25/45 - Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
• B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor
• C02F 1/50 - Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment
• C02F 1/68 - Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water

Abstract

The present invention addresses the problem of providing a novel method which is for preparing a DNA fragment for microbial cell transformation, and by which the combinatorial library of a long-chain DNA can be efficiently constructed and confirmation of the genotype of the obtained clone is facilitated. The present invention is a method for preparing a DNA fragment, which is for microbial cell transformation and has at least one insert DNA unit that includes a DNA containing an effective replication origin in a host microorganism and an insert DNA in which unit DNAs are linked, the method being characterized by including: (A) a step for preparing, through an OGAB method, a plurality of types of plasmids having an insert DNA unit in which a plurality of types of unit DNAs capable of being linked in a specific linking order are linked; (B) a step for decomposing a plasmid into unit DNAs by treating the plurality of types of plasmids prepared in the step (A) with a restriction enzyme suitable for each plasmid and preparing a mixed liquid of a plurality of types of unit DNAs; and (C) a step for preparing a long-chain DNA fragment by re-assembling the unit DNAs through the OGAB method by using the mixed liquid of a plurality of types of unit DNAs obtained in the step (B).

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

Abstract

An antisense oligonucleotide is provided which induces exon skipping in ACE2 gene. An antisense oligonucleotide of 15-30 bases or a salt or a solvate thereof, wherein the antisense oligonucleotide has a nucleotide sequence complementary to a target site in exon 18 of angiotensin-converting enzyme 2 gene and is capable of inducing exon skipping in angiotensin-converting enzyme 2 gene. A pharmaceutical drug comprising the antisense oligonucleotide or a salt or a solvate thereof; and an agent for inhibiting the expression of angiotensin-converting enzyme 2 protein and/or for enhancing the expression of soluble angiotensin-converting enzyme 2.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 31/12 - Antivirals

Abstract

An analysis method includes: performing liquid chromatography using a mobile phase including an adsorption prevention agent for preventing adsorption of a sample including a compound having a phosphate group to metal; and performing mass spectrometry on an eluate of the liquid chromatography. The adsorption prevention agent includes an oxalic acid or a salt of the oxalic acid.

IPC Classes  ?

• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
• G01N 30/72 - Mass spectrometers
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission

Abstract

Provided are a method for preparing human pluripotent stem cell-derived Leydig-like cells that are capable of stably and continuously secreting testosterone, and human pluripotent stem cell-derived Leydig-like cells. Further, provided are human pluripotent stem cell-derived Leydig-like cells that are capable of maintaining Leydig-like cells secreting a sufficient amount of testosterone for a long time and having improved differentiation induction efficiency. The aforesaid method comprises a step for culturing human pluripotent stem cells under culture conditions with the addition of one or more substances selected from the group consisting of a WNT canonical pathway activator, BMP4 (bone morphogenetic protein 4) and VEGF (vascular endothelial growth factor) to thereby forcedly express NR5A1, while adjusting the timing of cAMP (cyclic adenosine monophosphate) addition or removal, floating culture, adhesion culture, etc.

IPC Classes  ?

• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A61K 31/568 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstane, testosterone
• A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells
• A61P 15/00 - Drugs for genital or sexual disordersContraceptives
• A61P 15/10 - Drugs for genital or sexual disordersContraceptives for impotence
• C12N 5/02 - Propagation of single cells or cells in suspensionMaintenance thereofCulture media therefor
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

This physical property value predicting method includes: acquiring a prediction target image G1 obtained by imaging a material for prediction; and inputting the prediction target image G1 into a prediction model and outputting, as a predicted value, a physical property value (Y) relating to the material appearing in the prediction target image G1, the prediction model having been subjected to machine learning to accepting input of images obtained by imaging materials, as predictor variables, and to output the physical property value (Y) relating to the material.

IPC Classes  ?

• G01N 23/2251 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material using electron or ion microprobes using incident electron beams, e.g. scanning electron microscopy [SEM]
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated

Abstract

The present invention provides a photocatalyst electrode and a method for manufacturing a photocatalyst electrode, the photocatalyst electrode exhibiting higher catalytic activity than conventional hematite catalysts and being capable of extracting hydrogen peroxide with greater efficiency than the conventional hematite catalysts.　The present invention is obtained by layering a catalyst layer on a first principal surface of a substrate, and is configured such that the catalyst layer is formed by superposition and partial fixing of a plurality of hematite-based crystal particles; a shell layer being formed on the surface of a core body in the hematite-based crystal particles; the core body having iron oxide as the main component; the shell layer having a double oxide including a first metal and a second metal as the main component and an average thickness of 1-7 nm; and an oxide of the first metal and an oxide of the second metal each exhibiting photocatalytic activity.

IPC Classes  ?

• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
• B01J 23/745 - Iron
• B01J 23/835 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with germanium, tin or lead
• B01J 27/135 - HalogensCompounds thereof with titanium, zirconium, hafnium, germanium, tin or lead
• B01J 35/02 - Solids
• B01J 35/08 - Spheres
• B01J 37/08 - Heat treatment
• C25B 1/55 - Photoelectrolysis
• C25B 11/03 - ElectrodesManufacture thereof not otherwise provided for characterised by shape or form perforated or foraminous

Abstract

The present disclosure provides a system for culturing animal cells by using, as a source of nutrient, components derived from a living organism such as algae, and for reutilizing a waste culture liquid obtained therefrom.　The present disclosure provides a living organism or a cultured cell, which has undergone a modification. Said modification includes providing or enhancing the ability to utilize L-lactic acid in the living organism or the cultured cell. The present disclosure also provides a method for culturing, in recycling-oriented manner, at least two types of cells, which are cell X and cell Y, the method comprising: a step (a) for providing components excreted from the cell X to the cell Y; a step (b) for providing components originating from the cell Y to the cell X; a step (c) for culturing the cell X and the cell Y; and, as necessary, a step (d) for repeating steps (a)-(c). At least one of the components excreted from the cell X is a component that can be utilized by the cell Y. At least one of the components originating from the cell Y is a nutritional component for the cell X.

IPC Classes  ?

• C12P 13/04 - Alpha- or beta-amino acids
• C12P 19/04 - Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
• C12N 5/07 - Animal cells or tissues
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
• C12N 1/12 - Unicellular algaeCulture media therefor
• C12N 1/13 - Unicellular algaeCulture media therefor modified by introduction of foreign genetic material
• C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 15/31 - Genes encoding microbial proteins, e.g. enterotoxins
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 15/53 - Oxidoreductases (1)
• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12P 7/56 - Lactic acid
• C12P 7/62 - Carboxylic acid esters
• A23L 13/00 - Meat productsMeat mealPreparation or treatment thereof

Abstract

Provided is a thermoelectric generation module including a plurality of p-type thermoelectric elements 24a and a plurality of n-type thermoelectric elements 24b alternately connected in series and mounted with sandwiched by first and second flexible printed circuit boards 32, 33. The p-type thermoelectric elements and the n-type thermoelectric elements have a chip size of 1 mm or less and 0.2 mm or greater and a height of 0.8 mm or greater and 3 mm or less.

IPC Classes  ?

• H10N 10/17 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects operating with only the Peltier or Seebeck effects characterised by the structure or configuration of the cell or thermocouple forming the device
• H10N 10/01 - Manufacture or treatment

Abstract

The purpose of the present invention is to provide a method for manufacturing a substitute for palm oil that can be performed on a mass scale at a low cost.　The method for manufacturing a fat/oil of the present invention comprises: step A for culturing a yeast belonging to the genus Lipomyces; step B for disrupting the yeast belonging to the genus Lipomyces to give an emulsion; step C for separating the emulsion into a residue and a liquid by passing through a nonwoven or woven fabric; step D for dissolving the fat/oil in the residue in a solvent; and step E for collecting the fat/oil by volatilizing the solvent. The solvent is a mixed solvent consisting of n-hexane and ethanol at a mixing ratio of 2:1 to 5:1. Preferably, the nonwoven or woven fabric has an average pore size of 0.5-10 μm inclusive and an air permeability of from 2 cm3/(cm2∙s) to 45 cm3/(cm2∙s).

IPC Classes  ?

• C12P 7/64 - FatsFatty oilsEster-type waxesHigher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl groupOxidised oils or fats
• B01D 29/01 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with flat filtering elements
• B01D 29/11 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with bag, cage, hose, tube, sleeve or like filtering elements
• B01D 35/02 - Filters adapted for location in special places, e.g. pipe-lines, pumps, stop-cocks

Abstract

The present invention provides an organelle transformant screening method. More specifically, the present invention provides an organelle transformant screening method utilizing inhibition of a lipid synthetic pathway.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

Abstract

A method for producing a hollow fine particulate containing a fluorine-containing resin and having a large average particle size. The method includes dispersing a solution containing a fluorine-containing monomer, a phase separation promoter, and a non-polymerizable solvent into water to provide a dispersion, and polymerizing the fluorine-containing monomer to provide a hollow fine particulate containing a fluorine-containing resin.

IPC Classes  ?

• C08F 220/12 - Esters of monohydric alcohols or phenols

Abstract

The purpose of the present invention is to provide a method for producing a high-quality fluorine-containing polyurethane without using an isocyanate, and to provide a fluorine-containing biscarbamate compound using said method. This production method for a fluorine-containing polyurethane represented by formula (III) is characterized by including a step for reacting a fluorine-containing biscarbamate compound represented by formula (I) with a diol compound represented by formula (II). (In the formulas, Rf11-61-6 alkyl group, Rf22-102-10 alkanediyl group, and R1 indicates a bivalent organic group.)

IPC Classes  ?

• C08G 18/80 - Masked polyisocyanates
• C07C 271/20 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
• C08G 71/04 - Polyurethanes

Abstract

The purpose of the present invention is to provide a method for efficiently producing a high-quality polyurethane. This polyurethane production method is characterized by including: a step for obtaining a carbonate compound by reacting a specific fluorocarbonate compound with a polyol compound; and a step for reacting the carbonate compound with a specific amino compound.

IPC Classes  ?

• C08G 71/04 - Polyurethanes

Abstract

Provided is an artificial biomembrane that contains a membrane protein and retains lateral diffusion properties. Also provided is a method for producing an artificial biomembrane that contains a membrane protein and retains lateral diffusion properties. The method for producing an artificial biomembrane comprises a step for partly laminating a polymer lipid membrane (b) on the surface of a substrate (a) and laminating a fluidizing lipid membrane (c) together with a membrane protein (d) with a peptide nanodisc on a region of the surface of the substrate (a) on which the polymer lipid membrane (b) is not laminated. In the artificial biomembrane thus produced, the membrane protein (d) is reconstructed with a high probability and the lateral diffusion properties can be retained.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

An embodiment of the present invention is to provide a bioabsorbable medical material having adhesiveness to a biological tissue and improved degradability. A bioabsorbable medical material according to an embodiment of the present invention contains a crosslinked polymer material forming a specific shape, and a disintegration delaying material retained by the crosslinked polymer material. The crosslinked polymer material has degradability in water, the degradability being suppressed in the presence of an acid. The disintegration delaying material releases 0.5 mol%/day or greater of an acid until the seventh day upon contact with water at 37° C.

IPC Classes  ?

• A61L 31/04 - Macromolecular materials
• A61L 27/20 - Polysaccharides
• A61L 15/28 - Polysaccharides or their derivatives

Abstract

An organic fine particle comprising a core polymer and a shell polymer. The core polymer has a Tg or a melting point of 15° C. or more, the core polymer has a water contact angle of 100° or more, all monofunctional monomers constituting the core polymer are a hydrophobic core monomer of which homopolymer has a water contact angle of 100° or more, the shell polymer has a Tg or a melting point lower than Tg or the melting point of the core polymer, the shell polymer has a water contact angle of less than 100°, and all monofunctional monomers constituting the shell polymer are a water-insoluble shell monomer of which homopolymer is water-insoluble. Also disclosed is a surface coating structure including the organic fine particle and a water-repellant composition including a dispersion of the organic fine particle.

IPC Classes  ?

• C08L 51/06 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers grafted on to homopolymers or copolymers of aliphatic hydrocarbons containing only one carbon-to-carbon double bond
• C09D 151/06 - Coating compositions based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCoating compositions based on derivatives of such polymers grafted on to homopolymers or copolymers of aliphatic hydrocarbons containing only one carbon-to-carbon double bond

Abstract

The present invention provides novel spherical crosslinked particles which have an average particle diameter of 1 µm or more and a particle size dispersity (CV value) of 20% or less, wherein: each spherical crosslinked particle contains a repeating unit derived from a hydrophobic monomer which is not crosslinkable, and a homopolymer of which has a contact angle with water of 90° or more. Due to the surface relief effect thereof, the spherical crosslinked particles are able to impart a base material with water repellency.

IPC Classes  ?

• C08J 3/12 - Powdering or granulating
• C08F 220/62 - Monocarboxylic acids having ten or more carbon atomsDerivatives thereof
• C08F 265/00 - Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group
• C09K 3/18 - Materials not provided for elsewhere for application to surface to minimize adherence of ice, mist or water theretoThawing or antifreeze materials for application to surfaces

Abstract

The purpose of the present disclosure is to provide a production method by which it is possible to produce hollow fine particles which contain a fluorine-containing resin and have a large average particle diameter. This method for producing hollow fine particles includes: a step A for obtaining a dispersion liquid by dispersing a solution containing a fluorine-substituted monomer and a non-polymerizable solvent in water; a step B for obtaining phase separated fine particles containing a fluorine-containing resin by polymerizing the fluorine-substituted monomer; and a step C for obtaining hollow fine particles by removing the non-polymerizable solvent present in the phase separated fine particles.

IPC Classes  ?

• C08F 16/24 - Monomers containing halogen
• C08F 24/00 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygen
• B01J 13/14 - Polymerisation, crosslinking

Abstract

A robot hand (10) comprises a first finger part (A), a second finger part (B), a base part (20), and a drive part (DA1). The first finger part (A) comprises a base end link part (A1) that is connected to the base part (20), an intermediate link part (A2) that is connected to the base end link part (A1), a tip end link part (A3) that is connected to the intermediate link part (A2), a passive joint part (PA2) that rotatably supports the base end link part (A1) and the intermediate link part (A2), a passive joint part (PA3) that rotatably supports the intermediate link part (A2) and the tip end link part (A3), and a spring element (SA2) that holds the base end link part (A1) and the intermediate link part (A2) in a basic posture.

IPC Classes  ?

• B25J 15/08 - Gripping heads having finger members

Abstract

[Problem] To provide a filter for a mechanical ventilator, which can remove nitrogen monoxide favorably on the gas discharge side. [Solution] Provided is a filter 10 which is provided in a gas discharge circuit in a mechanical ventilator circuit equipped with an exhalation circuit and an exhaust circuit through which nitrogen monoxide is inhaled by a patient and which can remove nitrogen monoxide. The filter 10 is provided with: a housing 20 provided with an inhalation port 21 and an exhaust port 22; a first filtering material 30 that is arranged on the inhalation port side in the housing 20 and oxides nitrogen monoxide to generate nitrogen dioxide; and a second filtering material 40 that is arranged on the exhaust port side relative to the first filtering material 30 in the housing 20 and removes nitrogen dioxide.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents

Abstract

The present invention provides a separation function layer in which leakage of ionic liquid is minimized and which offers improved strength. A separation function layer 1 according to the present invention comprises: an ionic liquid L; a polymer A which forms a crystalline structure in the ionic liquid L; and a polymer B which differs from the polymer A. A separation membrane 10 according to the present invention is provided with the separation function layer 1 and a porous support 3 that supports the separation function layer 1.

IPC Classes  ?

• B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor
• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/32 - Polyalkenyl halides containing fluorine atoms
• B01D 71/34 - Polyvinylidene fluoride
• B01D 71/40 - Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters