Abstract

In a variable capacitor, a first electrode layer is provided and an insulation layer is disposed on the first electrode layer. At least one second electrode layer section is arranged in at least one first region that is defined on the insulation layer. At least one third electrode layer section is arranged in at least one second region that is defined on the insulation layer. The at least one second region is disposed apart from the at least one first region. A dielectric layer is at least partially arranged in at least one third region disposed on the insulation layer and interposed between the at least one first region and the at least one second region. A fourth electrode layer is disposed on the dielectric layer.

IPC Classes  ?

• H01G 7/06 - Capacitors in which the capacitance is varied by non-mechanical meansProcesses of their manufacture having a dielectric selected for the variation of its permitivity with applied voltage, i.e. ferroelectric capacitors

Abstract

Provided is a method for visualizing the foundation application status from a face video using a general RGB camera instead of using a multispectral camera or a special filter. The present invention comprises: an acquisition step for acquiring, using an RGB camera, a time-series vector R of a color variation of a bare skin part and time-series vectors of respective pixels in a part to be visualized; and a visual representation step for visually representing the foundation application status on the basis of evaluation of similarity between the time-series vector R and the time-series vectors of the respective pixels in the part to be visualized. Specifically, an inner product of the time-series vector R and the time-series vector of the part to be visualized is calculated for each pixel in the part to be visualized, and the foundation application status is visually represented on the basis of the component size of the time-series vector R for the time-series vectors of the respective pixels in the part to be visualized. The time-series vector is acquired from a time variation of green luminance in each pixel of the camera, while utilizing the characteristics of hemoglobin to absorb a green component of light.

IPC Classes  ?

• G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61Q 1/12 - Face or body powders, e.g. for grooming, adorning or absorbing
• G06T 1/00 - General purpose image data processing

Abstract

Provided is a production method in which a useful organic compound is continuously concentrated, separated, and recovered with low energy. Also provided are a production method and a production device for concentrating, separating, and recovering a useful organic compound after membrane extraction of the organic compound from a solvent. This production method: includes a concentration step for using a reverse osmosis membrane to concentrate, by osmotically assisted reverse osmosis (OARO), an organic compound extracted into an organic solvent that does not contain water; and includes, as a pre-step before the concentration step, an extraction step for using a separation membrane to extract, into the organic solvent, an organic compound that has dissolved in a solvent A. This production device is provided with: a solvent A in which an organic compound has been dissolved; an organic solvent; a hollow fiber membrane; a configuration A in which the solvent A circulates outside the hollow fiber membrane; a configuration B in which the organic solvent circulates inside the hollow fiber membrane; a reverse osmosis membrane; and a configuration C in which the organic solvent, after having passed through the inside of the hollow fiber membrane, flows on the high-pressure side of the reverse osmosis membrane and branches into a concentrated solution and a reflux solution, and the reflux solution flows on the low-pressure side of the reverse osmosis membrane and circulates as a diluted solution.

IPC Classes  ?

• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 61/10 - AccessoriesAuxiliary operations
• B01D 61/14 - UltrafiltrationMicrofiltration
• B01D 61/58 - Multistep processes
• B01D 63/02 - Hollow fibre modules
• B01D 69/08 - Hollow fibre membranes

Abstract

A method is capable of producing polyimide hollow particles does not require the use of template particles, does not require conditions of a high temperature and a high pressure, and is capable of producing polyimide hollow particles having excellent heat resistance. A polyimide hollow particle with excellent heat resistance which is obtained by such a production method is provided. A production method for polyimide hollow particles each having a shell portion and a hollow portion surrounded by the shell portion, including: preparing an inner oil phase containing polyamic acid fine particles and a solvent; preparing an outer oil phase containing a hydrocarbon-based solvent and at least one selected from the group consisting of a compound having a siloxane bond and a silicon dioxide; and carrying out a chemical imidization reaction in an emulsion prepared from the inner oil phase and the outer oil phase.

IPC Classes  ?

• B01J 13/16 - Interfacial polymerisation
• C08L 79/08 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors

Abstract

According to the present disclosure, there is provided a system for culturing animal cells using a component derived from an organism such as algae as a nutrient source, and reusing the culture waste liquid. The present disclosure provides an organism or a cultured cell which undergoes a modification, in which the modification includes imparting or enhancing L-lactate utilization ability in the organism or the cultured cell. In addition, the present disclosure provides a method for culturing at least two types of cells including a cell X and a cell Y in a circulation manner, the method including: a step (a) of providing a component excreted from the cell X to the cell Y; a step (b) of providing a component derived from the cell Y to the cell X; a step (c) of culturing the cell X and the cell Y; and a step (d) of repeating the steps (a) to (c) as necessary, in which at least one of the components excreted from the cell X is an assimilable component of the cell Y, and at least one of the components derived from the cell Y is a nutritional component of the cell X.

IPC Classes  ?

• C12P 7/56 - Lactic acid
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• C12N 1/12 - Unicellular algaeCulture media therefor
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12R 1/89 - Algae

Abstract

An optical tactile sensor (100) comprises: light-emitting units (10, 11, 12, 20, 21, 22) that are disposed on one of the back surface and the side surface of a person's finger (300) and that emit light; a light-receiving unit (30) that is disposed on the other of the back surface and the side surface of the finger (300) and that receives light; and a haptic data calculation unit (270) that calculates a pressure corresponding to the deformation of the finger (300) on the basis of light that has travelled from the light-receiving unit (30), passed through the finger (300), and reached the light-receiving unit (30).

IPC Classes  ?

• G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

Ultra-high potential pluripotent stem cells according to the present invention have ability to differentiate into cells of extraembryonic tissues of placenta and the like and/or a germ cell line, that is, ability to differentiate which is close to totipotency, in addition to properties of conventional pluripotent stem cells, that is, ability to differentiate into embryonic tissues which are all cells constituting a body. Thus, having the ability to differentiate into embryonic tissue cells of placenta or the like, the ultra-high potential pluripotent stem cells can reconstruct a damaged site of the extraembryonic tissue and improve or recover the function of the damaged site and also can be used for reproductive treatment such as infertility treatment, in addition to conventional regenerative medicine to various diseases involving damage to any of all parts that constitute a body. Further, the ultra-high potential pluripotent stem cells may be more effectively applied to a new regenerative medicine field, having excellent ability to proliferate and excellent ability to differentiate.

IPC Classes  ?

• C12N 5/074 - Adult stem cells
• C12N 5/0735 - Embryonic stem cellsEmbryonic germ cells
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

A composition for a forgery prevention layer for forming a forgery prevention layer in a semiconductor device includes pattern formation particles formed by an inorganic material having a refractive index n of 3 or more.

IPC Classes  ?

• H01L 23/29 - Encapsulation, e.g. encapsulating layers, coatings characterised by the material
• H01L 23/31 - Encapsulation, e.g. encapsulating layers, coatings characterised by the arrangement
• B41M 3/14 - Security printing

Abstract

Provided is a method for removing cellulose-derived impurities from an ionic liquid and effectively recovering the ionic liquid.　This method is for recovering a liquid comprising an ionic liquid and a cosolvent from an impurity-containing liquid comprising the ionic liquid, the cosolvent, and cellulose-derived impurities, the method including treating the impurity-containing liquid with an ultrafiltration membrane and thereby separating the liquid comprising the ionic liquid and the cosolvent from the cellulose-derived impurities.

IPC Classes  ?

• B01D 61/14 - UltrafiltrationMicrofiltration

Abstract

Provided is a method for effectively recovering a liquid containing an ionic liquid by removing a coloring component from the ionic liquid.　Disclosed is a method for recovering a liquid containing an ionic liquid from a colored liquid containing an ionic liquid and a coloring component, the method comprising separating the liquid containing an ionic liquid from the coloring component by supplying the colored liquid to a nanofiltration membrane or a reverse osmosis membrane.

IPC Classes  ?

• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties

Abstract

[Problem] To provide an air conditioning system which uses an existing air conditioning device to make it possible to promote energy saving. [Solution] An air conditioning system 1 comprises: first to fourth air conditioning devices 10-1 to 10-4 which are respectively capable of independently performing air conditioning in first to fourth air-conditioned spaces 3-1 to 3-4 that are directly or indirectly in communication with each other; and an overall control unit 23 which controls the first to fourth air conditioning devices 10-1 to 10-4 such that, when performing overall control for controlling the first to fourth air conditioning devices 10-1 to 10-4 such that some of the first to fourth air-conditioned spaces 3-1 to 3-4 are supply spaces that are supplied with air-conditioning air and the other air-conditioned spaces are exhaust spaces that discharge return air, the air-conditioning air is supplied to the supply spaces and the return air from the exhaust spaces is discharged.

IPC Classes  ?

• F24F 11/46 - Improving electric energy efficiency or saving

Abstract

[Problem] To provide an air-conditioning system capable of carrying out introduction of outside air in order to further enhance the energy-saving effect. [Solution] An air-conditioning system 1 comprises: an air-conditioning device 10 that introduces outside air into a space 3 to be air-conditioned; a first acquisition unit 20 that acquires a predicted temperature of the outside air; and a control unit 40 that controls the timing of introduction of the outside air into the space 3 to be air-conditioned by the air-conditioning device 10, by using the predicted temperature of the outside air acquired by the first acquisition unit 20. The control unit 40 controls the air-conditioning device 10 so that outside air having the lowest temperature is introduced into the space 3 to be air-conditioned when cooling is to be performed on the space 3 to be air-conditioned, and controls the air-conditioning device 10 so that outside air having the highest temperature is introduced into the space 3 to be air-conditioned when heating is to be performed on the space 3 to be air-conditioned.

IPC Classes  ?

• F24F 11/72 - Control systems characterised by their outputsConstructional details thereof for controlling the supply of treated air, e.g. its pressure
• F24F 3/02 - Air-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatmentApparatus specially designed for such systems characterised by the pressure or velocity of the primary air
• F24F 7/007 - Ventilation with forced flow
• F24F 7/08 - Ventilation with ducting systems with forced air circulation, e.g. by fan with separate ducts for supplied and exhausted air
• F24F 110/10 - Temperature
• F24F 110/20 - Humidity

Abstract

1233H and that has ene-reductase activity with respect to the α,β-unsaturated carbonyl compound, and/or a cell that is capable of expressing said protein.

IPC Classes  ?

• C12P 7/24 - Preparation of oxygen-containing organic compounds containing a carbonyl group
• C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 15/53 - Oxidoreductases (1)

Abstract

Provided are polyimide hollow particles having a shell portion and a hollow portion surrounded by the shell portion, the polyimide hollow particles having excellent heat resistance and excellent dielectric properties. Also provided is a method for producing such polyimide hollow particles.　Polyimide hollow particles according to the embodiment of the present invention have a shell portion and a hollow portion surrounded by the shell portion, and have a dielectric loss tangent of less than 0.0070 at a measurement frequency of 10 GHz.

IPC Classes  ?

• C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
• C08J 3/12 - Powdering or granulating

Abstract

An arithmetic device includes a plurality of multiply-add circuits, each of which includes a plurality of multipliers and a first adder, each of the plurality of multipliers being configured to multiply a data pair of significands of floating-point number data, and the first adder being configured to add results of the multiplication by the plurality of multipliers and a correction value; and an addition circuit configured to add operation results output from the plurality of multiply-add circuits and output a result of the addition as a matrix multiplication result of significand data of any of a plurality of types of floating-point number formats.

IPC Classes  ?

• G06F 17/16 - Matrix or vector computation
• G06F 7/487 - MultiplyingDividing

Abstract

Provided is a γδ T cell for securing the purity and number of cells sufficient for treatment. Also provided is a method of generating the γδ T cell. More specifically, provided are homogeneous γδ T cells excellent in that the γδ T cells are not affected by exhaustion of the cells. The foregoing is achieved by γδ T cells obtained by subjecting induced pluripotent stem cells (iPS cells) to differentiation induction treatment. Specifically, the foregoing is achieved by γδ T cells generated by subjecting iPS cells having a rearranged γδ TCR gene (γδ TCR-type iPS cells) to differentiation induction treatment. According to the method of generating the γδ T cell of the present invention, there can be provided γδ T cells and a cell population of γδT cells that have an excellent function of having antigen-specific cytotoxic activity in an MHC-unrestricted manner, and that are more homogeneous and have a higher effect than γδ T cells separated from peripheral blood.

IPC Classes  ?

• A61K 40/42 - Cancer antigens
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61K 40/32 - T-cell receptors [TCR]
• A61P 35/00 - Antineoplastic agents
• C07K 14/725 - T-cell receptors
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

[Problem] The purpose of the present invention is to provide a method and a system which are for producing a separation/concentration product of a volatile substance, and which are capable of concentrating the volatile substance to a high concentration and suppressing energy consumption and material consumption by using a small-sized apparatus. [Solution] This method for producing a separation/concentration product of a volatile substance is for concentrating an aqueous solution containing a volatile substance or for isolating the volatile substance, and is characterized by comprising the following steps. The method is characterized in that the volatile substance is selectively adsorbed in the following adsorption step and/or the volatile substance is selectively desorbed in the following desorption step. Step 1: Vaporization step Step 2: Adsorption step Step 3: Desorption step

IPC Classes  ?

• B01D 61/36 - PervaporationMembrane distillationLiquid permeation
• B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
• B01J 20/34 - Regenerating or reactivating
• C07C 29/76 - SeparationPurificationStabilisationUse of additives by physical treatment
• C07C 31/04 - Methanol
• C07C 31/08 - Ethanol

Abstract

In order to evaluate laryngeal motion during swallowing in a non-invasive and simple manner, the present invention provides a method for quantitatively evaluating laryngeal motion, the method making it possible to create a laryngeal motion curve and, on the basis of the laryngeal motion curve, evaluate the laryngeal elevation speed, the laryngeal elevation distance, and the laryngeal elevation duration. The cervical median shape of a subject is acquired, shape feature points are detected from the acquired shape, a laryngeal motion curve is created from the temporal change in the positions of the shape feature points accompanying a prescribed action, and the laryngeal motion in the prescribed action is quantitatively evaluated. When the prescribed action is performed, the temporal change in the position of a cervical median convexity corresponding to the laryngeal prominence is measured. If the position of the cervical median convexity cannot be detected, then the laryngeal motion curve is created by using the temporal change in the positions of shape feature points other than the cervical median convexity, including cervical median concavities located above and below the cervical median convexity. The prescribed action is an action in which the larynx is moved, said action including a swallowing action and a vocalization action.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

Provided are a method of producing a human pluripotent stem cell-derived Leydig-like cell (Leydig-like cells) capable of secreting testosterone stably and persistently, and a human pluripotent stem cell-derived Leydig-like cell. Also provided is a human pluripotent stem cell-derived Leydig-like cell that enables long-term maintenance of a Leydig-like cell secreting a sufficient amount of testosterone, and is improved in efficiency of differentiation induction. The method includes the steps of: culturing a human pluripotent stem cell under a culture condition with addition of one or a plurality of kinds selected from the group consisting of: a WNT canonical pathway activator; bone morphogenetic protein 4 (BMP4); and vascular endothelial growth factor (VEGF); and forcedly expressing NR5A1, and is achieved by controlling the timing of addition and removal of cyclic adenosine monophosphate (cAMP), suspension culture, adhesion culture, and the like.

IPC Classes  ?

• A61K 35/52 - SpermProstateSeminal fluidLeydig cells of testes
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

This crushing tool comprises: a sheath; a tip member attached to a tip of the sheath; and a basket wire protruding from a tip of the tip member. The tip member has a wire guide for guiding the basket wire. The wire guide is disposed radially outward from a tip surface of the tip member.

IPC Classes  ?

• A61B 17/221 - Calculus gripping devices in the form of loops or baskets

Abstract

The present disclosure provides a cancer gene therapy technique having an enhanced cancer inhibition effect. The inventors have found the possibility that an excellent cancer inhibition effect can be obtained using an oncolytic adenoviral vector comprising a nucleic acid, which contains an artificial gene obtained by fusing a CD44 extracellular portion, a Notch core region, and HIF-3α4, and an E1A gene and an E1B gene that are arranged under the control of a COX-2 promoter, and in which the artificial gene, the E1A gene, and the E1B gene are arranged in the same orientation, and thereby completed the present disclosure.

IPC Classes  ?

• C12N 15/861 - Adenoviral vectors
• A61K 35/761 - Adenovirus
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 15/00 - Drugs for genital or sexual disordersContraceptives
• A61P 35/00 - Antineoplastic agents
• C12N 15/12 - Genes encoding animal proteins

Abstract

The present disclosure provides a method for evaluating in vitro the effect of a test substance such as a food product or a drug candidate compound on the intestinal flora in a mammal, especially a human. Specifically, the present disclosure provides a method for evaluating a test substance in intestinal flora, wherein the method, etc. comprises the following steps: A) a step for culturing the intestinal flora in a culture medium for a period of time that is effective for reaching an original equilibrium state after starting culture by inoculating the intestinal flora into the culture medium; B) a step for adding the test substance to the culture medium containing the intestinal flora after passage of the abovementioned time; and C) a step for acquiring and evaluating evaluation items before and after the addition of the test substance.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C12N 15/09 - Recombinant DNA-technology
• C12Q 1/6869 - Methods for sequencing

Abstract

The present disclosure provides a composition useful for in vitro assessment of the effect of an analyte, such as a food or drug candidate compound, on mammal, particularly human, intestinal flora. Specifically, the present disclosure provides a polymeric glycoprotein-containing composition for promoting and/or maintaining original equilibration when culturing intestinal flora in a culture medium. The composition is used so that a mucin, for example, is included in a culture medium. A GAM culture medium or a modification thereof can be used as the culture medium.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms

Abstract

The present disclosure provides a method for evaluating, in vitro, the influence of a test substance such as a food or a drug candidate compound on intestinal bacterial flora in a mammal, particularly a human. More specifically, the present disclosure provides a method for increasing at least one of α-diversity (such as Shannon coefficient), OTU and the like with an increase in the content of intestinal bacterial flora added to a culture medium for culturing in a container in an original equilibrated state, the method being characterized by using no stirring device.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12N 15/09 - Recombinant DNA-technology
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• C12Q 1/6869 - Methods for sequencing

Abstract

An oil production method includes: culturing a yeast belonging to the genus Lipomyces; disrupting the yeast belonging to the genus Lipomyces and obtaining an emulsion; separating the emulsion into a residue and a liquid by passing the emulsion through a non-woven fabric or a woven fabric; dissolving the oil contained in the residue into a solvent; and evaporating the solvent and collecting the oil. The solvent is a solvent mixture of n-hexane and ethanol at a n-hexane:ethanol ratio of 2:1 to 5:1. The non-woven fabric or the woven fabric has an average pore size of 0.5 to 10 μm and an air permeability of 2 to 45 cm3/(cm2·s)

IPC Classes  ?

• C11B 1/10 - Production of fats or fatty oils from raw materials by extracting
• B01D 29/01 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with flat filtering elements

Abstract

Provided is a bidirectional DC-DC converter that is capable of balancing an inductor current and a DC bus voltage operation having a step-up/step-down voltage ratio with a wide range, and that further improves a voltage ratio and output power. The present invention is configured from a pair of bidirectional DC-DC converters 1 for a two-phase interleaving scheme charge pump. Positive and negative electrodes on a low-voltage side of each of the DC-DC converters are connected in parallel to a low-voltage-side DC bus, one end of each of the high-voltage sides is connected to a positive and negative electrode of a high-voltage-side DC bus, and the other ends of each are brought into a floating state. A high-voltage-side voltage is obtained by superimposing a low-voltage-side voltage on a charge pump capacitor voltage of each DC-DC converter. In a drive circuit 2, the upper limit or lower limit of the on-time ratio of drive pulses of some switches to be controlled for each of a step-down mode and a step-up mode is asymmetrically provided to an amplification value of the error between a reference value and a composite value of the inductor currents of the four phases.

IPC Classes  ?

• H02M 3/155 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only

Abstract

The resin composition contains polylactic acid and a copolyester of lactic acid and another hydroxycarboxylic acid. The copolyester has a weight-average molecular weight of 110,000 or more, and in the copolyester, the copolymerization randomness calculated by the ratio (b/a) of the theoretical value (b) of the triad ratio of the other hydroxycarboxylic acid to the measured value (a) of the triad ratio of the other hydroxycarboxylic acid is 0.5-3.0. The copolyester of lactic acid and another hydroxycarboxylic acid can be used as a soil biodegradation accelerator for promoting the soil biodegradation of polylactic acid.

IPC Classes  ?

• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
• C08L 101/16 - Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable
• C12N 1/20 - BacteriaCulture media therefor
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material

Abstract

The purpose of the present invention is to provide a method for producing carbonyl halide safely, at low cost, and with low environmental impact. A method for producing carbonyl halide according to the present invention is characterized by comprising a step for irradiating a mixed gas containing methane, an elemental halogen gas, and oxygen with light.

IPC Classes  ?

• C01B 32/80 - Phosgene
• C07B 61/00 - Other general methods
• C07C 68/02 - Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
• C07C 69/96 - Esters of carbonic or haloformic acids
• C07C 249/02 - Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
• C07C 263/10 - Preparation of derivatives of isocyanic acid by reaction of amines with carbonyl halides, e.g. with phosgene
• C07D 263/44 - Two oxygen atoms

Abstract

A method for producing a medical immobilization device, including: obtaining medical image data of a site of a body of a patient; extracting an outer shape of the site from the obtained medical image data; preparing a block made of a material that allows radiation to pass through; obtaining basic shape data of the block; subtracting the extracted outer shape of the site from the basic shape data of the block, to thereby obtain data of a holder portion having such a shape to allow at least a region from a lower surface to both sides of the site of the body of the patient to be fitted therein with an entire surface of the region being in contact; and processing the block to thereby form the holder portion. The block includes multiple parts, and the data of the holder portion has multiple pieces each for a part thereof.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

Provided is a novel technique for providing a substrate advantageous when producing a sensor for analysis. The substrate for producing a sensor for analysis provided in the present disclosure has specific characteristics (for example, monodispersion, a single layer, or a specific density), such that it is possible to produce a sensor for analysis that is stable and enables highly accurate analysis. In the present disclosure, it is not required to remove excess fine particles after arranging the fine particles on the substrate, reproducibility of the density of the fine particles immobilized on the substrate is improved, and monodispersibility and single-layer properties are also improved.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

4244343244 (R being a hydrogen atom or an alkyl group).

IPC Classes  ?

• G01N 30/26 - Conditioning of the fluid carrierFlow patterns
• G01N 30/02 - Column chromatography
• G01N 30/72 - Mass spectrometers
• G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups

Abstract

The object of the present invention is to provide a Ras/Raf binding inhibitory compound exhibiting a Ras/Raf signaling inhibitory action even against cancer cells bearing proved drug resistance and those with a variety of Ras mutations. The Ras/Raf binding inhibitory compound of the present invention is represented by the following formula (I) (wherein A, B, X, and R1 to R4 are as defined in the present description). The object of the present invention is to provide a Ras/Raf binding inhibitory compound exhibiting a Ras/Raf signaling inhibitory action even against cancer cells bearing proved drug resistance and those with a variety of Ras mutations. The Ras/Raf binding inhibitory compound of the present invention is represented by the following formula (I) (wherein A, B, X, and R1 to R4 are as defined in the present description).

IPC Classes  ?

• C07D 209/36 - Oxygen atoms in position 3, e.g. adrenochrome
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61P 35/00 - Antineoplastic agents
• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present disclosure provides a means for screening a material for inhibiting the exacerbation of glioblastoma cells. The present inventors have found the possibility of solving the problem by means of a method for screening a material having an exacerbation inhibiting action against glioblastoma cells, the method comprising a step for evaluating the Ror1 signaling inhibiting action of a test substance and/or a step for evaluating the Ror2 signaling inhibiting action of the test substance, thereby completing the present disclosure.

IPC Classes  ?

• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C12N 5/09 - Tumour cells

Abstract

[Problem] To provide a remote-controlled welding robot system capable of reducing misalignment between a welding part of a workpiece and a welding torch. [Solution] A welding robot system 10 comprises: a welding robot 11; a camera 12 that captures an image of a welding part that has not been welded in a workpiece 5; a display device 13 that displays the captured image; a reception unit 15 that receives an instruction to correct a welding position from an operator in response to displaying of the image; a robot control unit 16 that controls the welding robot 11 on the basis of instruction data to perform welding and that performs control for correcting the welding position in response to the received instruction; an accumulation unit 17 that accumulates positions of a plurality of points on a track of the welding performed by the welding robot 11; and a prediction unit 18 that predicts a welding path by using the accumulated positions of the plurality of points. The robot control unit 16 controls the welding robot 11 so as to move a welding torch on the predicted welding path.

IPC Classes  ?

• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
• B23K 9/10 - Other electric circuits thereforProtective circuitsRemote controls
• B23K 9/127 - Means for tracking lines during arc welding or cutting

Abstract

Provided is a device comprising a tunnel junction which can maintain a state of continuing to flow to a wide gap semiconductor side without returning electrons accumulated in a hetero interface to a narrow gap semiconductor side, and which can suppress the diffusion of electrons after excitation without restricting the movement of electrons before excitation, wherein output power is increased by increasing an open-circuit voltage. A solar cell 100 and an infrared sensor 110 have an undoped compound semiconductor layer 4 sandwiched by either or both of n-type or p-type doped compound semiconductor layers (2, 3). The undoped compound semiconductor layer 4 is a heterojunction of a wide gap semiconductor and a narrow gap semiconductor, and has, on the narrow gap semiconductor side near a hetero-interface 6, a quantum dot region 7 and a three-layer structure (double tunnel structure) 1 in which a p+-type degenerate semiconductor layer is sandwiched between two n+-type degenerate semiconductor layers.

IPC Classes  ?

• H10F 10/17 - Photovoltaic cells having only PIN junction potential barriers

Abstract

This program causes a computer to execute a process in which: singular value decomposition of a first Jacobian matrix is carried out, and a second Jacobian matrix is generated, the second Jacobian matrix including a first matrix, a second matrix, and a first singular matrix including a singular value in a diagonal element; on the basis of the result of comparing the singular value and a first threshold value, execution of a first process is determined when the singular value is a singular point or close to the singular point, and execution of a second process is determined when the singular value is distant from the singular point; in the first process, a third Jacobian matrix is generated by converting diagonal elements in the first singular matrix, and operation command values for a plurality of joints (JT) of a robot (10) are determined and outputted using the third Jacobian matrix and a movement command value for a moving part (12) of the robot (10); and in the second process, the operation command values are determined and outputted using the movement command value and either the first Jacobian matrix or the second Jacobian matrix.

IPC Classes  ?

• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements

Abstract

[Problem] To provide an air-conditioning device that is capable of handling a peak time of load and that is capable of performing an energy-saving operation at a time other than the peak time. [Solution] An air-conditioning device 1 comprises: a latent heat unit 10 that has a latent heat coil 11 and a latent heat blower 12 for sending, to an air-conditioning space, air that has been temperature-regulated by the latent heat coil 11; a sensible heat unit 20 that has a sensible heat coil 21 and a sensible heat blower 22 for sending, to the air-conditioning space, air that has been temperature-regulated by the sensible heat coil 21; an air-blowing unit 30 that has an air-blowing blower 32 for sending air to the air-conditioning space; and a control unit 42 that operates one or more units among the latent heat unit 10, the sensible heat unit 20, and the air-blowing unit 30.

IPC Classes  ?

• F24F 11/46 - Improving electric energy efficiency or saving
• F24F 3/044 - Systems in which all treatment is given in the central station, i.e. all-air systems
• F24F 11/83 - Control systems characterised by their outputsConstructional details thereof for controlling the temperature of the supplied air by controlling the supply of heat-exchange fluids to heat-exchangers
• F24F 11/89 - Arrangement or mounting of control or safety devices
• F24F 110/10 - Temperature
• F24F 110/20 - Humidity
• F24F 110/70 - Carbon dioxide
• F24F 120/00 - Control inputs relating to users or occupants

Abstract

As one embodiment, the present application discloses a muscle atrophy inhibitor that includes a long-chain hydroxylated fatty acid as an active ingredient.

IPC Classes  ?

• A61K 31/201 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having one or two double bonds, e.g. oleic or linoleic acid
• A23K 20/158 - Fatty acidsFatsProducts containing oils or fats
• A23L 33/12 - Fatty acids or derivatives thereof
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

The purpose of the present invention is to provide: a gas separation membrane which utilizes advantages of two or more kinds of metals, and which has more excellent gas separation performance; and a method for producing such a gas separation membrane.　This gas separation membrane is characterized by containing a composite metal oxide that includes two or more kinds of metals, and two or more kinds of organic ligands. It is preferable that the two or more kinds of metals are selected from the group consisting of group 2 metal elements, group 3 metal elements, group 4 metal elements, group 13 metal elements, and group 14 metal elements.

IPC Classes  ?

• B01D 71/02 - Inorganic material
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor
• B01D 71/06 - Organic material
• B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
• B01J 20/06 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group
• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
• B01J 20/30 - Processes for preparing, regenerating or reactivating
• C01G 23/00 - Compounds of titanium

Abstract

The purpose of the present invention is to provide: a composite hollow fiber membrane that maintains high levels of both permeability of liquid organic solvents and ability to block solutes in organic solvent-based liquids to be treated; and a method for manufacturing the composite hollow fiber membrane. This composite hollow fiber membrane comprises: an aliphatic polyamide hollow fiber membrane that has a dense layer and a support layer; and a functional separation layer that includes a cross-linked resin obtained through interfacial polycondensation. The functional separation layer is disposed on a surface of the dense layer, and the burst pressure measured under the following conditions is at least 2.25 MPa. Burst pressure: while N-methyl-2-pyrrolidone is passed into a module formed by using the composite hollow fiber membrane, pressure is raised 0.25 MPa at a time at ten-minute intervals, and the pressure (MPa) when the composite hollow fiber membrane ruptures is measured.

IPC Classes  ?

• B01D 69/08 - Hollow fibre membranes
• B01D 63/02 - Hollow fibre modules
• B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/56 - Polyamides, e.g. polyester-amides
• C08J 9/26 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out

Abstract

This seed treatment agent or soil treatment agent for controlling blight in small grain cereals is highly safe for small grain cereals, simple and efficient with a small labor load, and capable of exhibiting an excellent blight control effect. Said agent contains probenazole as an active ingredient. This method for controlling blight in small grain cereals includes treating, before sowing seeds of small grain cereals, the seeds or soil using the seed treatment agent or soil treatment agent for controlling blight in small grain cereals.

IPC Classes  ?

• A01N 43/80 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
• A01C 1/00 - Apparatus, or methods of use thereof, for testing or treating seed, roots, or the like, prior to sowing or planting
• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
• A01P 3/00 - Fungicides

Abstract

[Problem] To provide a temperature output device that makes it possible to know the temperature of each virtual area in a single air-conditioned space. [Solution] A temperature output device 10 comprises: a temperature acquisition unit 11 that acquires an area temperature that is the temperature of each of a plurality of areas into which a single air-conditioned space 50 is divided; and an output unit 12 that outputs the area temperature acquired by the temperature acquisition unit 11. Thus, each person present in the air-conditioned space 50 can know the area temperature of each area, and can move to an area having a temperature at which the person feels comfortable.

IPC Classes  ?

• F24F 11/80 - Control systems characterised by their outputsConstructional details thereof for controlling the temperature of the supplied air

Abstract

The present invention provides a prophylactic and/or therapeutic agent for a skin disorder associated with a histone deacetylase 4 abnormality. This prophylactic and/or therapeutic agent for a skin disorder associated with a histone deacetylase 4 abnormality contains a histone acetyltransferase inhibitor as an active ingredient. This prophylactic and/or therapeutic agent makes it possible to prevent and/or treat a skin disorder associated with a histone deacetylase 4 abnormality.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/121 - Ketones acyclic
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 31/365 - Lactones
• A61K 31/4155 - 1,2-Diazoles not condensed and containing further heterocyclic rings
• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61K 31/60 - Salicylic acidDerivatives thereof
• A61P 17/00 - Drugs for dermatological disorders
• A61P 17/16 - Emollients or protectives, e.g. against radiation
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C12N 9/99 - Enzyme inactivation by chemical treatment
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/15 - Medicinal preparations
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present invention provides, inter alia, a method for screening a substance that suppresses intramuscular adipose tissue (IMAT) formation. Provided are: a method for screening a substance that suppresses IMAT formation, the method comprising: (I) a step for bringing a Wnt5b protein, an Ror2 protein, and a test substance into contact with each other; and (II) a step for confirming that the test substance inhibits binding of the Wnt5b protein and Ror2 protein; and a composition for suppressing IMAT formation.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61P 21/04 - Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• G01N 33/15 - Medicinal preparations
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present invention provides a novel memory disorder ameliorating agent.　A PKCγ activity inhibitor is useful as an active ingredient for a memory disorder ameliorating agent.

IPC Classes  ?

• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C12N 9/99 - Enzyme inactivation by chemical treatment

Abstract

Provided is a component useful as an ATP scavenger and/or an ADP scavenger.　Transferrin is useful as an adenosine triphosphate scavenger, and butyrylcholinesterase is effective as an adenosine diphosphate scavenger.

IPC Classes  ?

• A61K 38/40 - Transferrins, e.g. lactoferrins, ovotransferrins
• A61K 38/46 - Hydrolases (3)
• A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors
• A61P 9/08 - Vasodilators for multiple indications
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• A61P 39/02 - Antidotes
• C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)
• C12Q 1/46 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase involving cholinesterase

Abstract

The purpose of the present invention is to provide a method for selectively identifying an immune reaction to a specific antigen, at the level of antibody sequences, from repertoire data for immune cell receptors. An immune reaction to a specific antigen can be selectively identified, at the level of antibody sequences, by this immune reaction evaluation method, the method including: a step A for preparing repertoire data of sequences for antigen recognition sites in immune cell receptors, wherein the repertoire data is acquired from a sample collected from a subject; and a step B for collating database of a sequence for an antigen recognition site against a specific antigen with the repertoire data to identify a sequence which is identical to the sequence included in the database or a sequence of which a portion excluding two or less amino acid residues is identical to the sequence included in the database at the level of amino acid sequences.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12N 15/44 - Orthomyxoviridae, e.g. influenza virus
• C12N 15/50 - Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

Provided is an artificial biological membrane containing a membrane protein retaining lateral diffusivity. Also provided is a method of producing an artificial biological membrane containing a membrane protein retaining lateral diffusivity. The artificial biological membrane is obtained by a method of producing an artificial biological membrane, the method including a step of partially laminating a polymer lipid membrane (b) on the surface of a substrate (a), followed by the lamination of a fluid lipid membrane (c) on the surface of the substrate (a), on which the polymer lipid membrane (b) is not laminated, together with a peptide nanodisc and a membrane protein (d). The membrane protein (d) is reconstituted in the produced artificial biological membrane at a high probability, and retains lateral diffusivity.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol

Abstract

Provided is a low-cost, favorably efficient production method for cellobiose. The method includes a step for reacting sucrose in a reaction liquid that contains glucose isomerase and yeast that has been made to express sucrose phosphorylase and cellobiose phosphorylase on the surface thereof.

IPC Classes  ?

• C12N 15/54 - Transferases (2)
• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12N 9/92 - Glucose isomerase
• C12P 19/12 - Disaccharides

Abstract

Provided is a bidirectional DC-DC converter having excellent performance for extending a voltage doubler characteristic in a discharge mode and a voltage divider characteristic in a charge mode over a wide range, and improving a voltage conversion ratio for use in a wide range of inputs/outputs. In an interleaved bidirectional DC-DC converter, a maximum limit or a minimum limit of an ON-time ratio, of drive pulses of a portion of switches to be controlled individually for each of a charge mode and a discharge mode, is asymmetrically provided with respect to an amplification value of an error between a combined value and a reference value of an inductor current of each phase, and the maximum limit or the minimum limit is switched.

IPC Classes  ?

• H02M 3/155 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only

Abstract

An object is to realize a novel reverse osmosis membrane (more specifically, reverse osmosis composite membrane) that is capable of suppressing biofouling. The object is attained with use of a reverse osmosis composite membrane which is obtained by chemically modifying a surface thereof with a compound that has an amino group and that is obtained by modifying the amino group with two molecules of α-picolyl group and has a dipicolylamine structure.

IPC Classes  ?

• B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 69/12 - Composite membranesUltra-thin membranes

Abstract

2-42-42-4halogenated hydrocarbon; an alcohol compound reaction step for reacting the oxidative photodecomposition product with an alcohol compound; and a base addition step for adding an inorganic base after the alcohol compound reaction step or adding an organic base at least after the oxidative photodecomposition step.

IPC Classes  ?

• C07C 68/00 - Preparation of esters of carbonic or haloformic acids
• C07C 69/96 - Esters of carbonic or haloformic acids
• C07B 61/00 - Other general methods

Abstract

The present invention provides a method for selecting a promoter that functions in an organelle, the method comprising: (1) the step of preparing sequence information obtained by RNA sequencing analysis; (2) the step of mapping the sequence information prepared in the step (1) onto a sequence of organellar DNA; (3) the step of calculating the amount of change in RNA expression in each region based on the mapping information obtained in the step (2); (4) the step of selecting regions in which the amount of change obtained in the step (3) is within a range of preset reference values; and (5) the step of identifying a region, among the regions selected, as a promoter functioning in an organelle.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The purpose of the present disclosure is to provide a production method by which hollow fine particles that contain a perfluoro resin and have a large average particle diameter and a single pore structure can be produced. The present disclosure provides a method for producing hollow fine particles, the method comprising: a step A for obtaining a dispersion liquid by dispersing, in water, a solution that contains a perfluoro monomer and a non-polymerizable solvent which has an SP value of 9.00 to 9.80 (cal/cm3)1/2 and is capable of dissolving the perfluoro monomer; a step B for obtaining phase-separated fine particles that contain a perfluoro resin and have a single pore structure by polymerizing the perfluoro monomer; and a step C for obtaining hollow fine particles that have a single pore structure by removing the non-polymerizable solvent from the phase-separated fine particles.

IPC Classes  ?

• B01J 13/14 - Polymerisation, crosslinking
• C08F 216/14 - Monomers containing only one unsaturated aliphatic radical
• C08F 224/00 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygen
• C08L 27/12 - Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogenCompositions of derivatives of such polymers not modified by chemical after-treatment containing fluorine atoms
• C08L 101/00 - Compositions of unspecified macromolecular compounds

Abstract

The purpose of the present invention is to provide: a composite hollow fiber membrane, in which the liquid permeability of an organic solvent and the blocking performance of a solute in an organic solvent-based liquid to be treated are both achieved to a great extent; and a method for manufacturing the same. This composite hollow fiber membrane includes: a polyamide hollow fiber membrane having a dense layer and a support layer; and a silicone layer. The silicone layer is provided on the surface of the dense layer.

IPC Classes  ?

• B01D 69/08 - Hollow fibre membranes
• B01D 61/14 - UltrafiltrationMicrofiltration
• B01D 63/02 - Hollow fibre modules
• B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/56 - Polyamides, e.g. polyester-amides
• B01D 71/70 - Polymers having silicon in the main chain, with or without sulfur, nitrogen, oxygen or carbon only
• C08J 9/26 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
• C08J 9/36 - After-treatment

Abstract

The present disclosure provides technology for adjusting the immune system of a subject. The present disclosure provides a composition that is for adjusting the immune system of a subject and that comprises titanium peroxide nanoparticles (TiOx NPs). The present disclosure also provides a composition that is for enhancing immunostimulation exhibited by other medical means administered to a subject and that comprises titanium peroxide nanoparticles (TiOx NPs).

IPC Classes  ?

• A61K 33/40 - Peroxides
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A61P 37/04 - Immunostimulants
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

An ion analysis method according to one embodiment of the present invention comprises: an ionization step for ionizing an object to be measured; an ion input step for inputting ions obtained in the ionization step or objective ions that are ions derived from said ions to a moving space (30) having a predetermined gas pressure adjusted within a range that allows particles to perform Brownian motion, and allowing the gravity and an electric field to act; a measurement step for acquiring first information on the motion by the action of the gravity and the electric field with respect to the objective ions inputted to the moving space, and acquiring second information on the Brownian motion; and a computation step for determining the mass or electric charge of the objective ions on the basis of the first and second information acquired in the measurement step. As a result, it is possible to accurately and efficiently measure the mass and electric charge of ions such as macromolecules and viruses.

IPC Classes  ?

• G01N 15/10 - Investigating individual particles
• G01N 27/622 - Ion mobility spectrometry
• H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

Abstract

A data processing device includes an instruction issue circuit configured to issue instructions; a plurality of execution circuits configured to execute, in parallel, the instructions issued from the instruction issue circuit; and a plurality of delay circuits configured to delay arrival timings of when the instructions issued from the instruction issue circuit arrive at the plurality of execution circuits, the plurality of delay circuits being arranged between the instruction issue circuit and the plurality of execution circuits. The arrival timings of the instructions arriving at at least two execution circuits included in the plurality of execution circuits are different from each other.

IPC Classes  ?

• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead

Abstract

21211 of the outside balloon 2.

IPC Classes  ?

• A61M 25/10 - Balloon catheters

Abstract

Provided is a cannula with which it is possible to effectively and antegradely send blood from the ascending aorta, while reducing the diameter. This cannula, in which the distal end part thereof is disposed in the ascending aorta and blood fed from an external-membrane-type artificial lung is sent antegradely from the ascending aorta, comprises an antegrade blood return part 2 and a blood-sending tube 4, the antegrade blood return part 2 being provided at the distal end of the blood-sending tube 4. A guide wire tube 5 extending in the longitudinal direction from the base end part to the distal end part is disposed substantially at the center of the axis inside the antegrade blood-sending cannula 1. The blood-sending tube 4 is a tube provided on the base end side connected to the extracorporeal-membrane-type artificial lung. The antegrade blood return part 2 reverses the blood in the antegrade direction from the reverse direction and directs the blood toward the base end side, and is composed of a first blood return tube 6 provided on the base end side and a second blood return tube 7 provided on the distal side. The second blood return tube 7 is provided with a side hole 7a and a side hole 7b, and a part of a substantially hemispherical bag body 8 is adhered to the inside of the distal end.

IPC Classes  ?

• A61M 60/178 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices

Abstract

The present invention makes it possible, even when the electrode arrangement is different from a predetermined electrode arrangement, to obtain a necessary multi-channel biological signal. A biological-signal-processing system according to the present disclosure is provided with: m electrodes that are attached to a living body in a first arrangement; and a signal-processing device that executes a process of inputting a p-channel first biological signal acquired from the m electrodes into a generation model and outputting a q-channel second biological signal from the generation model. The q-channel second biological signal is a signal corresponding to a signal obtained from n (n is an integer of 3 or more) electrodes attached to the living body in a second arrangement. The second arrangement is an electrode arrangement different from the first arrangement in terms of at least one of the number of electrodes and the attachment positions. The generation model is configured to output a q-channel second biological signal when a p-channel first biological signal is input.

IPC Classes  ?

• A61B 5/327 - Generation of artificial ECG signals based on measured signals, e.g. to compensate for missing leads

Abstract

The purpose of the present invention is to provide: a method for easily producing a high quality polyurethane including an isosorbide structure without using an isocyanate; and a high quality polyurethane that includes an isosorbide structure and that can be produced without using an isocyanate. A method for producing an isosorbide polyurethane according to the present invention is characterized by comprising a step for reacting an isosorbide-containing fluorinated alkyl biscarbonate, a soft segment polyamine monomer, and a hard segment polyamine monomer, and is characterized by adjusting the mole ratio of the soft segment polyamine monomer with respect to the total of the soft segment polyamine monomer and the hard segment polyamine monomer to 0.4-0.95.

IPC Classes  ?

• C08G 71/04 - Polyurethanes

Abstract

In the present invention, at least one of the genes (A) and (B) mentioned below is disrupted in a transformed microorganism belonging to the genus Cupriavidus.　Gene (A): a gene that encodes 2-hydroxy-acid dehydrogenase comprising an amino acid sequence represented by any one of SEQ ID NOs: 1 to 4, or a gene that encodes a protein which comprises an amino acid sequence having 90% or higher sequence identity to an amino acid sequence represented by any one of SEQ ID NOs: 1 to 4 and which has a 2-hydroxy-acid dehydrogenase activity. Gene (B): a gene that encodes a regulator protein which regulates the expression of at least one of the genes included in gene (A).

IPC Classes  ?

• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C08G 63/78 - Preparation processes
• C12N 15/09 - Recombinant DNA-technology
• C12N 15/53 - Oxidoreductases (1)
• C12P 7/52 - Propionic acidButyric acids
• C12P 7/56 - Lactic acid
• C12P 7/625 - Polyesters of hydroxy carboxylic acids

Abstract

[Problem] To provide a separation membrane capable of efficiently removing a substance (such as an ionic substance) in liquid, the separation membrane comprising an octosilicate material. To provide a molded article of a separation membrane for a substance in liquid, the molded article having high chemical resistance due to a separation membrane component, having high solvent permeability rate of the membrane for an organic solution containing a substance to be separated and capable of efficiently separating a substance (such as an ionic organic substance) in an organic liquid. [Solution] A composition for formation of a separation membrane for a substance in liquid, comprising component (A): a nitrogen-containing basic compound (A) that is a tertiary amine or a quaternary ammonium hydroxide having one or more alkyl groups with three or four carbon atoms, component (C): delamination particles (C) of a protonated layered polysilicate compound (B) and component (D): a solvent. A molded article of a separation membrane for a substance in liquid, comprising delamination particles (C) and a substrate (E) supporting the separation membrane for a substance in liquid.

IPC Classes  ?

• B01D 71/02 - Inorganic material
• B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/06 - Organic material
• B01D 71/10 - CelluloseModified cellulose
• B01D 71/14 - Esters of organic acids
• B01D 71/30 - Polyalkenyl halides
• B01D 71/34 - Polyvinylidene fluoride
• B01D 71/38 - PolyalkenylalcoholsPolyalkenylestersPolyalkenylethersPolyalkenylaldehydesPolyalkenylketonesPolyalkenylacetalsPolyalkenylketals
• B01D 71/40 - Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
• B01D 71/68 - PolysulfonesPolyethersulfones
• C01B 33/20 - Silicates

Abstract

Provided is a wastewater concentration device comprising: reverse osmosis membrane devices 5 and 8 to which wastewater is supplied; a pressure recovery device 20 that recovers pressure from concentrated water supplied from the reverse osmosis membrane devices; and osmotic pressure-assisted reverse osmosis membrane devices 31, 33, 33, and 35 through which the concentrated water that has passed through the pressure recovery device flows.

IPC Classes  ?

• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 61/06 - Energy recovery
• B01D 61/58 - Multistep processes
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis

Abstract

An anti-SIRPα antibody that can be used as a tumor agent and an anti-tumor agent comprising the antibody as an active ingredient. An antibody that binds specifically to human SIRPα to inhibit binding of human SIRPα to CD47.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes

Abstract

An object of the present invention is to provide a method for easily and efficiently evaluating the ability of test samples to trigger a foreign body reaction in the skin without using animals, a substance having an ability to inhibit a foreign body reaction in the skin, and a screening method for obtaining the substance. The above objects are attained by providing a method for evaluating an ability of a test sample to trigger a foreign body reaction in the skin, comprising: (1) a step of making a solution containing said test sample in contact with a keratinocyte transformed by a reporter vector comprising an enhancer sequence comprising a xenobiotic responsive element (XRE) and a reporter sequence encoding a reporter protein at downstream of said enhancer sequence, (2) a step of measuring an expression level of said reporter protein in said keratinocyte, and (3) a step of evaluating an ability of said test sample to trigger a foreign body reaction in the skin based on the measured expression level of said reporter protein; a method for screening a substance having an ability to inhibit a foreign body reaction in the skin using the evaluation method; and an agent for inhibiting a foreign body reaction in the skin comprising Fraglide-1, which was found using the screening method.

IPC Classes  ?

• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61K 31/365 - Lactones
• A61Q 19/08 - Anti-ageing preparations

Abstract

In one embodiment, the object of the present invention is to provide a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, and a method for reducing nephrotoxicity of the pharmaceutical composition. In one embodiment, the present invention relates to a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, wherein the nephrotoxicity reducing agent comprises a sugar alcohol and is used in an amount such that the concentration of the sugar alcohol in the pharmaceutical composition is 1 mg/ml to 400 mg/mL.

IPC Classes  ?

• A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
• A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
• A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Provided is a reagent which uses a novel combination of minimal residual disease (MRD) markers for neuroblastoma and which can improve the accuracy of evaluating the minimal residual disease of neuroblastoma. The reagent according to the present invention includes a primer pair capable of amplifying, by a nucleic acid amplification technique, the following: minimal residual disease genetic markers for neuroblastoma, comprising B4GALNT1, CHRNA3, CRMP1, DBH, PHOX2B, and TH; and a reference gene comprising HPRT1 and HMBS. The reagent is to be used for evaluating the minimal residual disease of neuroblastoma, and can improve the accuracy of evaluating the minimal residual disease of neuroblastoma.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12Q 1/686 - Polymerase chain reaction [PCR]

Abstract

The present invention provides a new separation function layer that is suited for separating an acidic gas from a gas mixture that includes the acidic gas. A separation function layer 1 according to the present invention comprises: an ionic liquid L; a hydrophilic polymer A that forms a crystal structure in the ionic liquid L; and a polymer B that is different from the polymer A. A separation membrane 10 according to the present invention comprises: the separation function layer 1; and a porous support 3 that supports the separation function layer 1.

IPC Classes  ?

• B01D 71/06 - Organic material
• B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor
• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/38 - PolyalkenylalcoholsPolyalkenylestersPolyalkenylethersPolyalkenylaldehydesPolyalkenylketonesPolyalkenylacetalsPolyalkenylketals
• B01D 71/44 - Polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds, not provided for in a single one of groups
• C08L 29/04 - Polyvinyl alcoholPartially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• C08L 39/06 - Homopolymers or copolymers of N-vinyl-pyrrolidones

Abstract

The purpose of the present invention is to provide a method for efficiently producing a high-quality reticulated polyurethane without using any isocyanate. The method for producing a reticulated polyurethane according to the present invention is characterized by including a step in which a fluorinated biscarbamate compound represented by formula (I) is reacted with a polyol compound represented by formula (II). [In the formulae, Rf11-61-6 fluoroalkyl group, Rf2represents a fluorinated divalent organic group, R1represents an n-valent organic group, R2 represents a divalent organic group, and n is an integer of 3-8.]

IPC Classes  ?

• C08G 18/80 - Masked polyisocyanates
• C08G 71/04 - Polyurethanes

Abstract

A variable capacitance capacitor (1) comprises: a first electrode layer (11); an insulating layer (31) disposed on the first electrode layer; a second electrode layer (21) disposed in a first region (RG1) on the insulating layer; a third electrode layer (22) disposed in a second region (RG2) separated from the first region on the insulating layer; a dielectric layer (32) disposed in a third region (RG3) at least between the first and second regions on the insulating layer; and a fourth electrode layer (12) disposed on the dielectric layer.

IPC Classes  ?

• H01G 7/06 - Capacitors in which the capacitance is varied by non-mechanical meansProcesses of their manufacture having a dielectric selected for the variation of its permitivity with applied voltage, i.e. ferroelectric capacitors
• H01G 4/30 - Stacked capacitors
• H01G 4/33 - Thin- or thick-film capacitors

Abstract

The present invention provides a complex containing a nucleic acid sequence-recognizing module and a proteolysis tag, wherein the module is linked to the proteolysis tag, the module specifically binds to a target nucleotide sequence in a double stranded DNA, and the tag consists of (i) a peptide containing 3 hydrophobic amino acid residues at the C-terminal, or (ii) a peptide containing 3 amino acid residues at the C-terminal wherein at least a part of the amino acid residues is substituted by serine

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/22 - Ribonucleases
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

The invention provides a method for producing a plant cell modified at a targeted site of a double-stranded DNA, including (i) a step of providing a plant cell comprising the double-stranded DNA of interest, (ii) a step of providing a complex in which a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in the double-stranded DNA and a DNA glycosylase with sufficiently low reactivity with the double-stranded DNA are bound, (iii) a step of placing the complex in a condition under which the plant cell is transfected, (iv) a step of placing the transfected plant cell in a condition that induces modification of the targeted site, without cleaving at least one strand of the double-stranded DNA in the targeted site, and (v) a step of selecting a cell into which the complex has been introduced and/or a cell into which the modification has been introduced.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 9/22 - Ribonucleases

Abstract

A method of inhibiting the function of myostatin is provided. A method of inhibiting the function of myostatin is provided. An antisense oligonucleotide of 15-30 bases or a salt or a solvate thereof, wherein the antisense oligonucleotide has a nucleotide sequence complementary to a target sequence in exon 3 of the myostatin gene and is capable of allowing the expression of a splicing variant of myostatin. A pharmaceutical drug, a food, a feed, an agent for promoting myocyte proliferation and/or hypertrophy, an agent for increasing muscle mass and/or suppressing muscle weakness, an agent for switching the splicing of the myostatin gene from production of myostatin to production of a splicing variant thereof, an agent for decreasing myostatin signaling, and an anticancer agent, each of which comprises the above antisense oligonucleotide or a salt or a solvate thereof.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A23K 20/153 - Nucleic acidsHydrolysis products or derivatives thereof
• A23L 33/13 - Nucleic acids or derivatives thereof
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

A therapeutic agent for hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) contains as an active ingredient a substance repairing c.854C>T mutation to C in TFG gene having c.854C>T and c.846T>C mutations. This substance may contain DNA that is transcribed in mammalian cells and a transduction medium introducing the DNA into the mammalian cells.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 35/76 - VirusesSubviral particlesBacteriophages
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

A reaction of a fluid in a reaction chamber is satisfactorily performed. A reaction of a fluid in a reaction chamber is satisfactorily performed. A fluid control method includes: generating, in a reaction chamber (84) formed between an outer cylinder (61) and an inner cylinder (70) coaxially disposed in the outer cylinder (61), a reaction phase (30) having a ring shape and formed of a reaction target fluid (F1, F2) in which a Taylor vortex (V1) is generated, the reaction phases (30) arranged in an axis (R) direction, and an inhibiting phase (31) having a ring shape that is adjacent to the reaction phase (30) in the axis (R) direction and inhibits the reaction target fluid (F1, F2) in the reaction phase (30) from flowing out to an outside of the reaction phase (30).

IPC Classes  ?

• B01J 19/18 - Stationary reactors having moving elements inside
• B01F 27/272 - Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces

Abstract

S. lycopersicum are found to be involved with the biosynthesis of leptine, which achieves resistance against Colorado potato beetle.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• A01H 1/00 - Processes for modifying genotypes
• A01H 6/82 - Solanaceae, e.g. pepper, tobacco, potato, tomato or eggplant
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

The purpose of the present invention is to provide a method for safely and efficiently producing a carbonyl halide. A method for producing a carbonyl halide according to the present invention is characterized by including a step for irradiating, in the presence of oxygen and ozone, a halomethane having one or more halogeno groups selected from the group consisting of chloro, bromo and iodo with light.

IPC Classes  ?

• C01B 32/80 - Phosgene
• C07C 68/02 - Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
• C07C 69/96 - Esters of carbonic or haloformic acids
• C07C 263/10 - Preparation of derivatives of isocyanic acid by reaction of amines with carbonyl halides, e.g. with phosgene
• C07C 265/04 - Derivatives of isocyanic acid having isocyanate groups bound to acyclic carbon atoms of a saturated carbon skeleton

Abstract

The purpose of the present invention is to provide an antibody against pancreatic cancer stem cells. This antibody against pancreatic cancer stem cells includes a heavy chain variable region including heavy chain CDRs described as HCDR1-HCDR3, and a light chain variable region including light chain CDRs described as LCDR1-LCDR3, and has an ability to bind to pancreatic cancer stem cells, where HCDR1 has an amino acid sequence located at positions 26-35 in SEQ ID NO: 1 or a sequence analogous thereto, HCDR2 has a sequence located at positions 47-65 in SEQ ID NO: 1 or a sequence analogous thereto, HCDR3 has a sequence located at positions 96-104 in SEQ ID NO: 1 or a sequence analogous thereto, LCDR1 has a sequence located at positions 24-34 in SEQ ID NO: 2 or a sequence analogous thereto, LCDR2 has a sequence located at positions 46-56 in SEQ ID NO: 2 or a sequence analogous thereto, and LCDR3 has a sequence located at positions 89-96 in SEQ ID NO: 2 or a sequence analogous thereto.

IPC Classes  ?

• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• A61P 35/00 - Antineoplastic agents
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

Provided are: a biological tissue retraction device capable of low invasive retraction of a biological tissue such as an organ while suppressing damage thereto and the like and of easily securing the surgical field; and a biological tissue retraction method using said biological tissue retraction device. This biological tissue retraction device for retracting a biological tissue to be retracted is provided with adhesion plates (2) formed from a material that is capable of adhering to a biological tissue by being brought into abutment thereagainst, and a holding member (3) that extends in one direction and holds a pair of the adhesion plates (2) on the two ends thereof in the extension direction, one of the pair of adhesion plates (2) being adhered to the biological tissue to be retracted and the other being adhered to a different biological tissue from the biological tissue to be retracted so as to maintain the retracted state of said biological tissue.

IPC Classes  ?

• A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors

Abstract

A processor includes an instruction decoder configured to decode an instruction including bypass information and generate a bypass control signal based on the bypass information; a data holding circuit configured to hold data to be used to execute the instruction; an arithmetic circuit configured to execute the instruction and output operation result data; and a first selector configured to select the data held in the data holding circuit or the operation result data based on the bypass control signal and output the selected data or the selected operation result data to the arithmetic circuit.

IPC Classes  ?

• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead

Abstract

A processor includes an arithmetic circuit configured to execute an arithmetic instruction; and a register configured to hold data used by the arithmetic circuit. The processor receives a data movement instruction and the arithmetic instruction corresponding to the data movement instruction, and moves the data from a first memory to the register based on a data movement instruction. The arithmetic circuit executes the arithmetic instruction after a data movement of the data movement instruction is completed.

IPC Classes  ?

• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode

Abstract

An operation circuit includes a plurality of multipliers each configured to multiply each of respective first mantissas of a plurality of first data to which a first common exponent is set as a common exponent, by each of respective second mantissas of a plurality of second data to which a second common exponent is set as a common exponent; and a first adder configured to add up a plurality of products calculated by the plurality of multipliers.

IPC Classes  ?

• G06F 7/544 - Methods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using non-contact-making devices, e.g. tube, solid state deviceMethods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using unspecified devices for evaluating functions by calculation
• G06F 5/01 - Methods or arrangements for data conversion without changing the order or content of the data handled for shifting, e.g. justifying, scaling, normalising
• G06F 7/485 - AddingSubtracting
• G06F 7/487 - MultiplyingDividing

Abstract

The disclosure provides for agents, compositions of the agent for the use in treating cancer by contacting a cancer cell with an agent to increase the tension of a plasma membrane of the cancer cell, thereby preventing or reducing cell migration and/or proliferation of the cancer cell and treating the cancer.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 38/45 - Transferases (2)
• A61K 38/46 - Hydrolases (3)
• A61K 47/02 - Inorganic compounds
• A61K 47/06 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

Abstract

Provided is a technology that can provide an excellent suppressive effect against adhesion of calculi or calcification in a medical device to be retained within the body. This agent for suppressing calculi adhesion or calcification contains polydopamine and/or a derivative thereof, and is used to form at least an outermost surface of a coating layer of a medical device to be retained within a urinary organ or a circulatory organ.

IPC Classes  ?

• A61L 27/34 - Macromolecular materials
• A61L 27/50 - Materials characterised by their function or physical properties
• A61L 29/08 - Materials for coatings
• A61L 31/10 - Macromolecular materials

Abstract

The present disclosure pertains to a remote operation device that remotely operates a movable body on the basis of operation information from an operator, the remote operation device comprising: a first reception unit that receives, via a transmission path, a first wave variable that is obtained by performing wave variable transformation of the state amount of the movable body and that is output from a movable-body control device that outputs a movable-body control amount for controlling the movable body; a first wave variable transformation unit that performs wave variable transformation of the first wave variable and an operation amount based on the operation information and that outputs the same respectively as a post-transformation state amount and a second wave variable; and a first transmission unit that transmits, via the transmission path, the second wave variable to the movable-body control device.

IPC Classes  ?

• H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom

Abstract

This wastewater concentration device and method comprise: an osmotically assisted reverse osmosis device that has a primary chamber and a secondary chamber which are separated by an osmotically assisted reverse osmosis membrane and that performs an osmotically assisted reverse osmosis method; and a water supply means for supplying to-be-treated water to the primary chamber. The water supply means uses a cation exchange device or an anion exchange device to treat at least a portion of the to-be-treated water so that the pH of the to-be-treated water to be supplied to the osmotically assisted reverse osmosis device ranges from a first prescribed pH to a second prescribed pH (where the first prescribed pH is an alkaline pH, and the second prescribed pH is the pH of an acidic pH).

IPC Classes  ?

• B01D 61/10 - AccessoriesAuxiliary operations
• B01D 71/16 - Cellulose acetate
• C02F 1/42 - Treatment of water, waste water, or sewage by ion-exchange
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis

Abstract

Provided is a method for altering a targeted site of a DNA in a cell, including a step of stimulating the cell with a factor inducing a DNA modifying enzyme endogenous to the cell, and bringing a complex of a nucleic acid sequence-recognizing module specifically binding to a target nucleotide sequence in a given DNA and a DNA modifying enzyme-binding module bonded to each other into contact with the DNA to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

Provided is a super-high-molecular gamma-polyglutamic acid having an average molecular weight of at least 20 million. Also provided is a Bacillus genus bacterium variant strain that can produce said super-high-molecular γ-PGA. Further provided is a method for screening for said Bacillus genus bacterium variant strain that can produce said super-high-molecular γ-PGA. The present invention produces Bacillus genus bacterium variant strain, and produces a gamma-polyglutamic acid having an average molecular weight of at least 20 million.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C12N 15/01 - Preparation of mutants without inserting foreign genetic material thereinScreening processes therefor
• C12N 15/31 - Genes encoding microbial proteins, e.g. enterotoxins
• C07K 14/32 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Bacillus (G)

Abstract

Provided is a γδT cell for securing the purity and number of cells sufficient for treatment. Also provided is a method of generating the γδT cell. More specifically, provided are homogeneous γδT cells excellent in that the γδT cells are not affected by exhaustion of the cells. The foregoing is achieved by γδT cells obtained by subjecting induced pluripotent stem cells (iPS cells) to differentiation induction treatment. Specifically, the foregoing is achieved by γδT cells generated by subjecting iPS cells having a rearranged γδTCR gene (γδTCR-type iPS cells) to differentiation induction treatment. According to the method of generating the γδT cell of the present invention, there can be provided γδT cells and a cell population of γδT cells that have an excellent function of having antigen-specific cytotoxic activity in a MHC-unrestricted manner, and that are more homogeneous and have a higher effect than γδT cells separated from peripheral blood.

IPC Classes  ?

• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• C07K 14/725 - T-cell receptors
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

This transformed microorganism of a microorganism belonging to the genus Cupriavidus, which has the ability to produce a copolyester of 3-hydroxybutyric acid and another hydroxyalkanoic acid, has: a gene encoding a copolyester synthase; and a foreign gene having an amino acid sequence represented by any of SEQ ID NOs: 2-6 and encoding propionyl CoA transferase or butyl CoA transferase, and/or a foreign gene having at least 90% sequence identity to an amino acid sequence represented by any of SEQ ID Nos: 2-6, and encoding a protein having propionyl CoA transferase activity or butyl CoA transferase activity.

IPC Classes  ?

• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 15/54 - Transferases (2)
• C12N 15/55 - Hydrolases (3)
• C12P 7/625 - Polyesters of hydroxy carboxylic acids

Abstract

The invention provides a site-specific modification method of a DNA molecule that enables gene function manipulation. In particular, the invention provides a method for manipulating gene function by a site-specific action on a target DNA molecule, said method comprising a step for preparing a complex containing an Argonaute protein, a guide RNA and an additional sequence and a step for contacting the target DNA molecule with the complex, wherein the guide RNA is designed to guide the complex to a region containing the desired site in the target DNA molecule.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

Provided is an orally administrable vaccine against a coronavirus infectious disease. A transformed Bifidobacterium designed to display a part or a whole of a constituent protein of a coronavirus on a surface of the Bifidobacterium enables the provision of the orally administrable vaccine against a coronavirus infectious disease. The transformed Bifidobacterium designed to display a part or a whole of a constituent protein of a coronavirus on a surface of the Bifidobacterium can induce humoral immunity and cellular immunity through oral administration to suppress an increase in severity of pneumonia or the like even after viral infection.

IPC Classes  ?

• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61P 31/14 - Antivirals for RNA viruses
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses

Abstract

Provided is a method capable of shortening the time required for analysis and capable of analyzing various substances produced by microorganisms. A method for analyzing a metabolite of a microorganism according to the present invention includes: a step of supplying a mobile phase including carbon dioxide in a liquid state, a subcritical state, or a supercritical state to a container in which a microorganism cultured in a medium is contained together with the medium, to move a component of a metabolite of the microorganism present in the microorganism and the medium to the mobile phase; a step of introducing a mobile phase to which a component of the metabolite has moved into a column; and a step of performing mass spectrometry on a component of the metabolite contained in the mobile phase that has passed through the column.

IPC Classes  ?

• G01N 30/72 - Mass spectrometers
• C12N 1/20 - BacteriaCulture media therefor
• G01N 30/04 - Preparation or injection of sample to be analysed
• G01N 30/26 - Conditioning of the fluid carrierFlow patterns

Abstract

Expression of matrix metalloproteinase 1 is suppressed. A matrix metalloproteinase 1 expression suppression agent of this disclosure contains, as an active ingredient, at least one selected from the group consisting of Saxifraga sarmentosa, an extract of Saxifraga sarmentosa, rosemary, an extract of rosemary, licorice, an extract of licorice, Melissa officinalis, an extract of Melissa officinalis, wild thyme, an extract of wild thyme, hop, and an extract of hop.

IPC Classes  ?

• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 36/484 - Glycyrrhiza (licorice)
• A61K 36/53 - Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• A61K 36/537 - Salvia (sage)

Abstract

A composition for fluorescent labeling according to the present invention comprises: a compound (A) which is an ICG compound; and a hydroxyl group-containing organic compound (B). This makes it possible to provide, for example, a composition for fluorescent labeling which has excellent compartment identifiability that allows an observation target to be more accurately identified, which has a long light emission time and thus makes it possible to observe the observation target for a long time, and which also reduces a burden on a living body and is excellent in economical efficiency.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• A61M 5/28 - Syringe ampoules or cartridges, i.e. ampoules or cartridges provided with a needle
• A61K 49/00 - Preparations for testing in vivo
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

A federated learning system in which a plurality of local servers repeatedly learn cooperatively through communications between the plurality of local servers and a central server via a network. The local server includes a decryption unit, a mean gradient calculation unit, a model updating unit, a validation error calculation unit, an encryption unit, and a local transmission unit that transmits at least one of a current local mean gradient and a current local validation error. The central server includes a central reception unit, a model selection unit, a weight determination unit, and a central transmission unit. The central reception unit receives encrypted current local models and at least one of current local training data counts, the current local mean gradients, and the current local validation errors from the plurality of respective local servers.

IPC Classes  ?

• G06N 3/098 - Distributed learning, e.g. federated learning

Abstract

The purpose of the present invention is to provide a novel affective disorder ameliorating agent. A PKCγ activity inhibitor is useful as an active ingredient for an affective disorder ameliorating agent.

IPC Classes  ?

• A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61P 25/18 - Antipsychotics, i.e. neurolepticsDrugs for mania or schizophrenia
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

The purpose of the present invention is to provide an esophagus-cooling agent capable of cooling the esophagus by a simple and easy means with a relatively small burden on a patient. The present invention pertains to an esophagus-cooling agent comprising a solvent and a compound (A). At least a portion of the compound (A) is a non-dissolved material that is not dissolved in the solvent when the esophagus-cooling agent is at 25°C. When differential scanning calorimetry (DSC) is performed on the esophagus-cooling agent in accordance with JIS K7122-2012, an endothermic signal that has a negative DDSC (value obtained by differentiating a heat flow by temperature) in a region where the temperature is in the range of 10-50°C and where the heat flow is at most 0 (W/g) can be observed, and the dynamic viscosity at 25°C is 100-5,000 mm2/s.

IPC Classes  ?

• A61L 31/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 31/14 - Materials characterised by their function or physical properties
• A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants