Abstract

A vapor phase epitaxial growth device comprises a reactor vessel and a wafer holder arranged within the reactor vessel. The wafer holder includes a wafer holding surface configured to hold a wafer with a wafer surface oriented substantially vertically downward. The device comprises a first material gas supply pipe configured to supply a first material gas and arranged below the wafer holding surface. The device comprises a second material gas supply pipe configured to supply a second material gas and arranged below the wafer holding surface. The device comprises a gas exhaust pipe configured to exhaust gases and arranged below the wafer holding surface. A distance between the gas exhaust pipe and an axis line passing through a center of the wafer holding surface is greater than distances between the axis line and each of the first material gas supply pipe and the second material gas supply pipe.

IPC Classes  ?

• C30B 35/00 - Apparatus not otherwise provided for, specially adapted for the growth, production or after-treatment of single crystals or of a homogeneous polycrystalline material with defined structure
• C30B 29/16 - Oxides
• C30B 29/36 - Carbides
• C30B 29/38 - Nitrides
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• C30B 23/02 - Epitaxial-layer growth
• C30B 23/06 - Heating of the deposition chamber, the substrate, or the materials to be evaporated

Abstract

A numerical control system according to the present invention controls machine drive systems included in a machine tool that performs machining using a tool, according to a numerical control program, and includes a coordinate transformation unit that acquires a disturbance force or a disturbance torque applied to each machine drive system, and coordinate-transforms the disturbance force or the disturbance torque into a tool reference coordinate system for output, and an identification unit that calculates cutting process parameters that determine characteristics of a cutting process model and dynamic characteristic parameters that determine characteristics of a dynamics model of the machine tool, using the disturbance force or the disturbance torque output from the coordinate transformation unit, states of the machine drive systems, predetermined equation models, and cutting conditions. The equation models define relationships between the cutting process parameters, the dynamic characteristic parameters, and the disturbance force or the disturbance torque.

IPC Classes  ?

• G05B 19/408 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by data handling or data format, e.g. reading, buffering or conversion of data

Abstract

wherein the total number of amino acid residues is 100 or less.

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 35/00 - Antineoplastic agents
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

The purpose of the present invention is to provide a novel medical application of pluripotent stem cells (muse cells) in regeneration medicine. The present invention provides a cell preparation and a pharmaceutical composition which are for amelioration and treatment of brain disorders resulting from fetal growth retardation, such as abnormal motor quality or abnormal neurological development, and which contain SSEA-3 positive pluripotent stem cells isolated from a mesenchymal tissue from a live body or cultured mesenchymal cells. It is assumed that this cell preparation is based on a mechanism where muse cells that are administered to objects having the disorders are engrafted on an impaired brain tissue, thereby ameliorating or treating the disorders.

IPC Classes  ?

• A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells
• C12N 5/0735 - Embryonic stem cellsEmbryonic germ cells
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia

Abstract

The present invention relates to methods and apparatus for depositing carbon nanostructures such as three-dimensional graphene mesh using non-equilibrium gaseous plasma of high power density. Methods are disclosed for rapid deposition of randomly distributed graphene sheets on surfaces of substrates using decomposition of CO molecules of a high potential energy, and said excited CO molecules interacting with a substrate. Another method uses a carbon containing precursor in condensed form and a processing gas comprising oxygen or an oxygen containing gas. The three-dimensional graphene mesh prepared according to the methods of invention is useful in different applications such as light absorbents, fuel cells, super- capacitors, batteries, photovoltaic devices and sensors of specific gaseous molecules.

IPC Classes  ?

• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
• H01M 4/04 - Processes of manufacture in general
• C23C 16/26 - Deposition of carbon only
• C23C 16/505 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using radio frequency discharges
• C23C 16/54 - Apparatus specially adapted for continuous coating
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof

Abstract

A bonding system includes a supporting jig having a mounting surface on bonding substrates which are mounted, a bonding device that sandwiches and welds the bonding substrates between itself and the mounting surface, an articulated robot to which the bonding device is attached, and a control unit that controls the articulated robot and the bonding device.

IPC Classes  ?

• B29C 65/02 - Joining of preformed partsApparatus therefor by heating, with or without pressure
• B29C 65/00 - Joining of preformed partsApparatus therefor
• B29C 65/08 - Joining of preformed partsApparatus therefor by heating, with or without pressure using ultrasonic vibrations
• B29C 65/32 - Induction
• B29C 65/78 - Means for handling the parts to be joined, e.g. for making containers or hollow articles
• B29L 31/30 - Vehicles, e.g. ships or aircraft, or body parts thereof

Abstract

A protrusion on a first member made of synthetic resin wherein a laser beam is applied to a side surface of the protrusion in a state in which a top surface of the protrusion of the first member is abutted against a second member made of synthetic resin, so as to melt at least the entire top surface of the protrusion and melt a portion of the second member in contact with the protrusion by heat of the melted top surface of the protrusion, followed by solidification of the melted portions, whereby the first member and the second member are welded together.

IPC Classes  ?

• B29C 65/16 - Laser beam
• B29K 307/04 - Carbon

Abstract

A carbon nanosheet, which is a sheet-form carbon nanomaterial having a larger area as compared with that of a similar conventional product and a side length of about 1 μm, and a method for producing the carbon nanosheet. The carbon nanosheet production method includes a step of mixing a solution of an iron atom-containing compound dispersed in a solvent with an alcohol, to thereby prepare a solution mixture; and a step of irradiating the solution mixture with plasma, to thereby produce a carbon nanosheet. The carbon nanosheet has a side length of 0.5 μm to 2.5 μm.

IPC Classes  ?

• C01B 32/15 - Nanosized carbon materials
• C22C 1/10 - Alloys containing non-metals
• C01B 32/05 - Preparation or purification of carbon not covered by groups , , ,
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures
• H05H 1/24 - Generating plasma

Abstract

A method for producing AlN crystals includes using at least one element, excluding Si, that satisfies a condition under which the element forms a compound with neither Al nor N or a condition under which the element forms a compound with any of Al and N provided that the standard free energy of formation of the compound is larger than that of AlN; melting a composition containing at least Al and the element; and reacting the Al vapor with nitrogen gas at a predetermined reaction temperature to produce AlN crystals.

IPC Classes  ?

• C09K 5/14 - Solid materials, e.g. powdery or granular
• C30B 29/38 - Nitrides
• C30B 29/62 - Whiskers or needles
• C01B 21/072 - Binary compounds of nitrogen with metals, with silicon, or with boron with aluminium
• C30B 25/00 - Single-crystal growth by chemical reaction of reactive gases, e.g. chemical vapour deposition growth

Abstract

Lactobacillus plantarum subgroup and/or the total number of intestinal bacteria as a marker, and a method for determining Parkinson's disease using the blood LPS level and/or the blood LBP level of a Parkinson's disease patient as an indicator.

IPC Classes  ?

• C12Q 1/06 - Quantitative determination
• C12Q 1/6851 - Quantitative amplification
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• C12N 1/20 - BacteriaCulture media therefor
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol
• C12R 1/24 - Lactobacillus brevis
• C12R 1/25 - Lactobacillus plantarum

Abstract

One aspect of the present disclosure is a medical treatment tool including a first arm having a first end and a second end and a second arm having a first end and a second end, wherein the first end of the first arm and the first end of the second arm are coupled such that a distance between the second end of the first arm and the second end of the second arm is adjustable. Each of the first arm and the second arm comprises: a conductor extending from the first end to the second end and exposed at the second end; a support containing a composite material made of a resin and a reinforcing material as a main component and extending along the conductor; and a cover covering the conductor and the support.

IPC Classes  ?

• A61B 18/14 - Probes or electrodes therefor
• A61B 18/08 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
• A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body

Abstract

The present invention addresses the problem of providing a technique for more conveniently delivering a polynucleotide in a less cytotoxic form into a cell. This problem is solved by a polynucleotide modified by a molecule that contains a structure that contains a disulfide bond and/or a thiol group.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides

Abstract

A numerical control system according to the present invention controls machine drive systems included in a machine tool that performs machining using a tool, according to a numerical control program, and includes a coordinate transformation unit that acquires a disturbance force or a disturbance torque applied to each machine drive system, and coordinate-transforms the disturbance force or the disturbance torque into a tool reference coordinate system for output, and an identification unit that calculates cutting process parameters that determine characteristics of a cutting process model and dynamic characteristic parameters that determine characteristics of a dynamics model of the machine tool, using the disturbance force or the disturbance torque output from the coordinate transformation unit, states of the machine drive systems, predetermined equation models, and cutting conditions. The equation models define relationships between the cutting process parameters, the dynamic characteristic parameters, and the disturbance force or the disturbance torque.

IPC Classes  ?

• G05B 19/408 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by data handling or data format, e.g. reading, buffering or conversion of data

Abstract

An electrochemical device has an electrochemical cell provided with an electrolyte having proton conductivity, an anode provided on one side of the electrolyte, and a cathode provided on the other side of the electrolyte. The electrochemical device is configured so that a solution containing water, an artificial synthetic resin, and an acid is supplied to the anode. The electrochemical device is configured so that an oxygen-containing gas is supplied to the cathode and connecting a load between the anode and the cathode. The electrochemical device is configured so that the inert gas is supplied to the cathode and connecting the voltage application unit between the anode and the cathode.

IPC Classes  ?

• H01M 8/0267 - CollectorsSeparators, e.g. bipolar separatorsInterconnectors having heating or cooling means, e.g. heaters or coolant flow channels
• H01M 4/96 - Carbon-based electrodes

Abstract

A main purpose of the present invention is to provide a multi-block copolymer composition having good elasticity and excellent stress relaxation properties, as well as small tension set. The present invention achieves the purpose by providing a multi-block copolymer composition obtained by a modification treatment, the composition including a block copolymer B formed by introducing a functional group capable of forming a non-covalent bond to a block copolymer A; wherein the block copolymer A includes a block copolymer A1 having a specific primary structure and a block copolymer A2 having a specific primary structure, and the mass ratio (A1/A2) of the block copolymer A1 and the block copolymer A2 is 100/0 to 50/50.

IPC Classes  ?

• C08F 297/04 - Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the anionic type polymerising vinyl aromatic monomers and conjugated dienes
• C08J 5/18 - Manufacture of films or sheets
• C08F 297/08 - Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the coordination type polymerising mono-olefins

Abstract

Provided is a technique relating to a vapor phase growth apparatus for a compound semiconductor. The vapor phase growth apparatus includes a reaction container. The vapor phase growth apparatus includes a wafer holder disposed in the reaction container. The vapor phase growth apparatus includes a first source gas supply pipe that supplies a first source gas into the reaction container. The vapor phase growth apparatus includes a second source gas supply pipe that supplies a second source gas which reacts with the first source gas into the reaction container. The vapor phase growth apparatus includes a specific gas supply pipe in which a solid part is disposed on a supply path. The vapor phase growth apparatus includes a first heating unit that heats the solid part to a predetermined temperature or higher. The solid part includes a matrix region and a first region continuously disposed in the matrix region. The matrix region is a region that does not decompose at the predetermined temperature. The first region is a region that decomposes at the predetermined temperature and includes Mg.

IPC Classes  ?

• C30B 25/14 - Feed and outlet means for the gasesModifying the flow of the reactive gases
• H01L 21/205 - Deposition of semiconductor materials on a substrate, e.g. epitaxial growth using reduction or decomposition of a gaseous compound yielding a solid condensate, i.e. chemical deposition
• C30B 29/38 - Nitrides
• C23C 16/34 - Nitrides
• C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials

Abstract

Provided is a carbon isotope analysis device including a carbon dioxide isotope generator provided with a combustion unit that generates gas containing carbon dioxide isotope from carbon isotope, and a carbon dioxide isotope purifying unit; a spectrometer including optical resonators having a pair of mirrors, and a photodetector that determines intensity of light transmitted from the optical resonators; and a light generator including a single light source, a first optical fiber that transmits first light from the light source, a second optical fiber that generates second light of a longer wavelength than the first light, the second optical fiber splitting from the first optical fiber and coupling therewith downstream, a first amplifier on the first optical fiber, a second amplifier on the second optical fiber, different in band from the first amplifier, and a nonlinear optical crystal.

IPC Classes  ?

• H01S 3/23 - Arrangement of two or more lasers not provided for in groups , e.g. tandem arrangement of separate active media
• H01S 3/067 - Fibre lasers
• H01S 3/08 - Construction or shape of optical resonators or components thereof
• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
• H01S 3/11 - Mode lockingQ-switchingOther giant-pulse techniques, e.g. cavity dumping
• H01S 3/16 - Solid materials
• G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
• G02F 1/355 - Non-linear optics characterised by the materials used
• G02F 1/365 - Non-linear optics in an optical waveguide structure

Abstract

Provided are a novel fused ring compound that exhibits excellent charge transport capacity, a production method therefor, and an organic EL element material containing said compound. This fused ring compound has a specific structure and is represented by formula (1).

IPC Classes  ?

• C07D 221/18 - Ring systems of four or more rings
• H01L 51/50 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for light emission, e.g. organic light emitting diodes (OLED) or polymer light emitting devices (PLED)
• C07D 239/70 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
• C07D 241/38 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms

Abstract

A carbon isotope analysis method comprising: a step for generating a carbon dioxide isotope from a carbon isotope; a step for filling an optical resonator having one pair of mirrors with the carbon dioxide isotope; a step for emitting irradiating light having an absorption wavelength for the carbon dioxide isotope inside the optical resonator; a step for adjusting the relative positional relationship of the mirrors to each other so that the optical axis of the irradiating light and the optical axis of light produced by the etalon effect coincide with one another; a step for irradiating the carbon dioxide isotope with the irradiating light, and measuring the intensity of the transmitted light obtained when resonance occurs; and a step for calculating the carbon isotope concentration from the intensity of the transmitted light. Provided is an optical resonator capable of suppressing a parasitic etalon effect, a carbon isotope analysis device using the same, and the carbon isotope analysis method.

IPC Classes  ?

• G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
• G01J 3/26 - Generating the spectrumMonochromators using multiple reflection, e.g. Fabry-Perot interferometer, variable interference filter
• G02F 1/37 - Non-linear optics for second-harmonic generation

Abstract

A light generator provided with a light source, an optical switch for turning light from the light source on and off, and mirrors for reflecting light from the optical switch and sending light back to the optical switch. Provided are: a light generator in which there are few residual errors in the fitting of ringdown signals; a radioactive isotope analysis device using the light generator; and a radioactive isotope analysis method.

IPC Classes  ?

• G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation
• G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
• G02F 1/11 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on acousto-optical elements, e.g. using variable diffraction by sound or like mechanical waves
• G02F 1/37 - Non-linear optics for second-harmonic generation

Abstract

2222.

IPC Classes  ?

• H01L 21/3065 - Plasma etchingReactive-ion etching

Abstract

A communication device stores a first secret key and a first public key, and the on-vehicle authentication device stores a second secret key, a second public key and a signature verification key. The on-vehicle authentication device acquires the first public key, verifies the authenticity of the electronic signature using a signature verification key, encrypts the second public key using the authentic first public key and transmits the encrypted second public key. The communication device receives the encrypted second public key, decrypts the encrypted second public key using the first secret key, encrypts the first public key using the decrypted second public key. The on-vehicle authentication device receives the encrypted first public key, decrypts the encrypted first public key using the second secret key, and authenticates that the communication device is an authentic device when the decrypted first public key has been determined to be authentic.

IPC Classes  ?

• H04L 29/06 - Communication control; Communication processing characterised by a protocol
• H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
• H04W 4/40 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P]
• G06K 15/00 - Arrangements for producing a permanent visual presentation of the output data
• H04L 9/08 - Key distribution
• H04L 9/30 - Public key, i.e. encryption algorithm being computationally infeasible to invert and users' encryption keys not requiring secrecy
• G06Q 50/26 - Government or public services

Abstract

Provided are a method, an apparatus, and a kit for detecting a neuroblastoma in a subject and/or for monitoring a therapeutic effect on the neuroblastoma, by measuring a urinary tumor marker(s) in a sample from the subject.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• G01N 30/06 - Preparation
• G01N 30/02 - Column chromatography

Abstract

An antitumor peptide provided according to the present invention includes (1) an S1PR-TM related sequence; and (2) an amino acid sequence functioning as a cell penetrating peptide; wherein the total number of amino acid residues is 100 or less.

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61P 35/00 - Antineoplastic agents
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

2-xx277 (where: R is at least one element selected from Zn, Ga, Fe, Sn, and Mn; and 0 ≤ x < 2).

IPC Classes  ?

• C04B 35/495 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on vanadium, niobium, tantalum, molybdenum or tungsten oxides or solid solutions thereof with other oxides, e.g. vanadates, niobates, tantalates, molybdates or tungstates
• C01G 31/00 - Compounds of vanadium
• C04B 35/626 - Preparing or treating the powders individually or as batches

Abstract

The present invention addresses the problem of providing a tight junction modulator that comprises a compound which is already on the market as a medicine or is already used as a quasi-drug or the like and which modulates tight junctions.　This problem can be solved by a tight junction modulator which comprises at least one selected from the compounds represented by formulas (1) to (4) and at least one selected from pharmaceutically acceptable salts of the compounds represented by formulas (1) to (4).　[Chem. 1]

IPC Classes  ?

• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 8/41 - Amines
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/60 - SugarsDerivatives thereof

Abstract

Provided is a dental treatment composition which exhibits excellent handleability and can facilitate formation of dentin. This dental treatment composition contains a compound (I) having a structure represented by general formula (1) and a dentin-forming agent (II). (In formula (1), R1is a hydrocarbon group, A is a -C(=O)-R2-O- group (R2is a specific alkylene group), B is a -C(=O)-C(-R3)(-R4)-O- group (R3is a hydrogen atom or a hydrocarbon group, and R4 is a hydrocarbon group), s is a number that is 0 or greater, m is 0-800, and n is 0-700. However, m and n cannot both be 0.)

IPC Classes  ?

• A61K 6/838 - Phosphorus compounds, e.g. apatite
• A61K 6/891 - Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C08L 67/00 - Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chainCompositions of derivatives of such polymers
• C08L 89/00 - Compositions of proteinsCompositions of derivatives thereof
• C08G 63/08 - Lactones or lactides

Abstract

Provided is a ternary or quaternary semiconductor nanoparticle that enables the band-edge emission and a less toxic composition. A semiconductor nanoparticle is provided that contains Ag, In, and S and has an average particle size of 50 nm or less, wherein the ratio of the number of atoms of Ag to the total number of atoms of Ag and In is 0.320 or more and 0.385 or less, the ratio of the number of atoms of S to the total number of atoms of Ag and In is 1.20 or more and 1.45 or less. The semiconductor nanoparticle is adapted to emit photoluminescence having a photoluminescence lifetime of 200 ns or less upon being irradiated with light having a wavelength in a range of 350 nm to 500 nm.

IPC Classes  ?

• C09K 11/62 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing gallium, indium or thallium
• H01L 33/50 - Wavelength conversion elements
• B82Y 40/00 - Manufacture or treatment of nanostructures
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals

Abstract

The present invention provides a device for efficiently capturing EVs with a simple operation procedure. According to the present invention, provided is, for example, a device that is to be used for capturing extracellular vesicles in a sample solution and that includes a nanostructure for capturing extracellular vesicles.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• G01N 1/04 - Devices for withdrawing samples in the solid state, e.g. by cutting

Abstract

The present invention provides a novel miRNA extraction method and a method for analyzing miRNA extracted by using said miRNA extraction method. According to the present invention, provided is, for example, a method for extracting miRNA from extracellular vesicles in a sample solution, by using a device capable of capturing extracellular vesicles, the miRNA extraction method comprising: an extracellular vesicle capturing step for capturing extracellular vesicles in a sample solution onto a device by bringing the sample solution and the device in contact with each other; and a miRNA extraction step for homogenizing the extracellular vesicles by bringing the device having captured the extracellular vesicles in contact with a homogenization liquid for extracellular vesicles to extract miRNA from the extracellular vesicle into the homogenization liquid.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A laser device for laser resonance ionization includes a wavelength variable grating-type titanium-doped sapphire laser and includes a titanium (Ti) doped titanium sapphire crystal disposed within a resonator. The titanium sapphire crystal is fixedly disposed on a stage. The titanium-doped sapphire crystal can be moved in the optical axis direction by the stage, thereby changing the position of the titanium-doped sapphire crystal. The switching between the wideband mode and the high-output mode can be performed by changing the position of the titanium-doped sapphire crystal.

IPC Classes  ?

• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
• H01S 3/06 - Construction or shape of active medium
• H01J 49/10 - Ion sourcesIon guns
• H01S 3/1055 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling the mutual position or the reflecting properties of the reflectors of the cavity one of the reflectors being constituted by a diffraction grating
• H01S 3/109 - Frequency multiplication, e.g. harmonic generation
• H01S 3/08 - Construction or shape of optical resonators or components thereof
• H01S 3/081 - Construction or shape of optical resonators or components thereof comprising three or more reflectors
• H01S 3/102 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling the active medium, e.g. by controlling the processes or apparatus for excitation
• H01S 3/094 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light
• H01S 3/16 - Solid materials

Abstract

A proton conducting film includes a polymer having a first part and a second part which are connected by a covalent bond and a plasticizer. The first parts aggregate with each other to form a domain at an operation temperature of the proton conducting film, and the second part crosslinks the domains. The second part has a proton accepting group, and the plasticizer contains a proton donating compound having a pKa of 2.5 or less, and thus the plasticizer penetrates into the second part, and a glass transition temperature of the polymer is lowered compared to when the plasticizer is not included.

IPC Classes  ?

• H01M 8/1023 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having only carbon, e.g. polyarylenes, polystyrenes or polybutadiene-styrenes
• C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
• H01M 8/0258 - CollectorsSeparators, e.g. bipolar separatorsInterconnectors characterised by the configuration of channels, e.g. by the flow field of the reactant or coolant
• H01M 8/10 - Fuel cells with solid electrolytes

Abstract

The present invention addresses the problem of providing a novel therapeutic drug for mental illness with abnormal neurodevelopment. Provided is an antipsychotic containing a Rho kinase inhibitor as an active ingredient. The antipsychotic can be utilized, for example, in the treatment of schizophrenia, autism spectrum disorders, bipolar disorder, or depression.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/18 - Antipsychotics, i.e. neurolepticsDrugs for mania or schizophrenia
• A61P 25/24 - Antidepressants
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

This moving control method for a plurality of vehicles moves the plurality of vehicles to a target location set individually in each of the plurality of vehicles, and includes: a step for acquiring each location of the plurality of vehicles; a step for determining a control input for moving each of the plurality of vehicles from the acquired location to a location separated by a first distance from the target location while satisfying a prescribed condition; and a step for updating the first distance to a shorter distance, when the distance between each location of the plurality of vehicles and each of the target locations is equal to or longer than the first distance and within the updated distance.

IPC Classes  ?

• G05D 1/02 - Control of position or course in two dimensions

Abstract

A method for screening for a chemical substance comprises: acquiring a plurality of feature amounts, wherein each of the feature amounts is associated with the morphology of cells included in a microscopic image of cells in each of a plurality of cell groups to which different chemical substances are added at different concentrations; and determining the similarity between the different chemical substances on the basis of the plurality of the feature amounts associated with the morphologies of the cells.

IPC Classes  ?

• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

Abstract

A plurality of fiber layers (a) and a resin (b) that is in contact with the fiber layers (a) are included in a simulated sclera 2, the fiber diameters of fibers constituting the fiber layers (a) being set to 0.6-170.0 μｍ inclusive, and the plurality of fiber layers (a) being laminated and the laminated fiber layers (a) being impregnated with the resin (b), whereby the simulated sclera 2 is obtained.

IPC Classes  ?

• G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
• C08G 18/06 - Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen

Abstract

[Problem] To provide a method for producing nanoparticles, in which metal nanoparticles are continuously produced in-line. [Solution] In this method for producing metal nanoparticles, a solution containing a metal or a metal compound flows through a flow path LP1 of a plasma processing device 100, and plasma is generated in a plasma generation region PG1 facing the flow path LP1. The solution is irradiated with the plasma while flowing through the flow path LP1, so that metal nanoparticles are generated inside the solution. Plasma gas is a gas generated when a solvent of the solution is volatilized or the atmosphere. The pressure of the plasma is 0.01 atm to 0.9 atm inclusive.

IPC Classes  ?

• B22F 9/24 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
• B82Y 40/00 - Manufacture or treatment of nanostructures
• H05H 1/46 - Generating plasma using applied electromagnetic fields, e.g. high frequency or microwave energy

Abstract

A multilayer body which comprises an electrode layer and a semiconductor layer that contains a group III-V nitride semiconductor, and which is configured such that: the electrode layer contains magnesium oxide and zinc oxide; the molar ratio of magnesium to the total of magnesium and zinc in the electrode layer, namely Mg/(Mg + Zn) is from 0.25 to 0.75 (inclusive); and the electrical conductivity of the electrode layer is 1.0 × 10-2 S/cm or more.

IPC Classes  ?

• C23C 14/08 - Oxides
• C23C 14/14 - Metallic material, boron or silicon
• C23C 14/58 - After-treatment
• H01L 21/28 - Manufacture of electrodes on semiconductor bodies using processes or apparatus not provided for in groups
• H01L 29/43 - Electrodes characterised by the materials of which they are formed

Abstract

Provided is a technique for appropriately embedding, in a rotating electric machine control device for controlling a rotating electric machine, a damping function for reducing a transfer torque vibration transferred to the rotating electric machine. The rotating electric machine control device (10) for drive-controlling a rotating electric machine (80) in a dq-axes vector coordinate system is provided with a feedback controller (1) which calculates a voltage command (V*) for the rotating electric machine (80) in each of a d-axis and a q-axis, and which feedback-controls the rotating electric machine (80), wherein the gain of the feedback controller (1) for the q-axis is set so that a voltage command (V*) for outputting a damping torque for attenuating a transfer torque vibration (Tn) is calculated on the basis of a back electromotive force of the rotating electric machine (80) caused by the transfer torque vibration (Tn).

IPC Classes  ?

• H02P 21/05 - Arrangements or methods for the control of electric machines by vector control, e.g. by control of field orientation specially adapted for damping motor oscillations, e.g. for reducing hunting
• H02P 21/06 - Rotor flux based control involving the use of rotor position or rotor speed sensors

Abstract

[Problem] To lower the cost in a separation method that separates semiconducting carbon nanotubes from carbon nanotubes in which metal and semiconducting carbon nanotubes are mixed. [Solution] A method for separating semiconducting carbon nanotubes, the method being one in which: a first substance, a second substance that separates into two phases when mixed with the first substance in a state of solution, sodium dodecyl sulfate, sodium cholate, and carbon nanotubes in which a mixture of metal and semiconducting carbon nanotubes are present are mixed with a solvent to produce a dispersion; the dispersion is separated into a first layer containing mainly the first substance and a second layer containing mainly the second substance; and the semiconducting carbon nanotubes are moved to either the first layer or the second layer, wherein the method is characterized in that the first substance is an α-glucan in which glucose is linked by α-glucoside bonds, the weight-average molecular weight Mw is 4000-7000, and the ratio of α-1,6 bonded glucose residues to total glucose residues is 40-70%.

IPC Classes  ?

• C01B 32/172 - Sorting
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C01B 32/159 - Carbon nanotubes single-walled
• C01B 32/174 - DerivatisationSolubilisationDispersion in solvents

Abstract

22.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation

Abstract

The present invention addresses the problem of providing a laser microdissection device that can accurately collect, as compared to the related art, a sample having a predetermined size even when a sample to be collected is small. The laser microdissection device collects a sample by radiating a dissection laser beam, the device comprising: a laser radiation unit for radiating the dissection laser beam; a first lens that converts the dissection laser beam radiated from the laser radiation unit into a parallel light beam; a diaphragm part that shields a peripheral portion light of the parallel light beam; and a second lens that collects the parallel light beam focused by the diaphragm portion. The problem is solved by the laser microdissection device.

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• G01N 1/04 - Devices for withdrawing samples in the solid state, e.g. by cutting

Abstract

A main object of the present invention is to provide a block copolymer composition which has good elasticity, while having excellent stress relaxation properties. The object is achieved by providing a block copolymer composition obtained by a modification treatment, the block copolymer composition comprising a block copolymer B formed by introducing a functional group capable of forming a non-covalent bond into a block copolymer A including at least one aromatic vinyl polymer block and at least one conjugated diene polymer block.

IPC Classes  ?

• C08L 53/02 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers of vinyl aromatic monomers and conjugated dienes
• C08J 5/18 - Manufacture of films or sheets
• C08F 297/08 - Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the coordination type polymerising mono-olefins

Abstract

This structure material is provided with: a base material for forming a structure; and an ion supply source present inside or on the surface of the base material, the ion supply source supplying a cation and/or an anion constituting a hardly soluble salt having a solubility equal to or less than a first value in water at the temperature of an environment in which the base material is arranged.

IPC Classes  ?

• C04B 41/50 - Coating or impregnating with inorganic materials
• C04B 41/48 - Macromolecular compounds
• C04B 41/63 - Macromolecular compounds
• C04B 41/65 - Coating or impregnating with inorganic materials
• E02D 29/05 - Underground structures, e.g. tunnels or galleries, built in the open air or by methods involving disturbance of the ground surface all along the location lineMethods of making them at least part of the cross-section being constructed in an open excavation or from the ground surface, e.g. assembled in a trench
• E21D 11/10 - Lining with building materials with concrete cast in situShuttering or other equipment adapted therefor
• E21D 13/02 - Methods
• G21F 9/34 - Disposal of solid waste

Abstract

The present invention addresses the problem of providing a compound library which has a higher percentage of biologically active compounds. This problem is solved by a compound library that includes cyclic peptides that comprise (i) an amino acid sequence interposed between cysteine residues in a cysteine-rich protein, or (ii) an amino acid sequence that has an identity of 80% or more with an amino acid sequence interposed between cysteine residues in a cysteine-rich protein.

IPC Classes  ?

• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof
• C07K 2/00 - Peptides of undefined number of amino acidsDerivatives thereof

Abstract

Provide is an artificially synthesized antitumor peptide that may suppress proliferation of tumor cells. The peptide provided is a synthetic peptide that contains both (1) an amino acid sequence that forms a signal peptide of a membrane protein, programmed cell death-1 (PD-1), or a modified amino acid sequence thereof in which 1, 2 or 3 amino acid residues deleted from, substituted in or added to the above amino acid sequence; and (2) an amino acid sequence that serves as a cell penetrating peptide (CPP), and wherein the synthetic peptide comprises a total of 100 or fewer amino acid residues.

IPC Classes  ?

• A61P 35/00 - Antineoplastic agents
• C07K 19/00 - Hybrid peptides
• A61K 38/00 - Medicinal preparations containing peptides
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants

Abstract

The present invention appropriately evaluates a risk when a subject moves. This information processing device is provided with a head information acquisition unit, a display control unit, a viewpoint information acquisition unit, and a risk assessment unit. The head information acquisition unit acquires head information specifying the movement of a head of a subject. The display control unit causes an image display device to display a simulative moving image simulatively representing the field of view of a person that moves on a course. The simulative moving image includes a scene including a target, and changes according to the movement of the head of the subject specified by the head information. The viewpoint information acquisition unit acquires viewpoint information specifying the position of a viewpoint of the subject on the simulative moving image while the simulative moving image is being displayed. The risk assessment unit assesses a risk on the basis of the degree of a match between the position of the viewpoint of the subject specified by the viewpoint information and the position of the target at a timing when the scene including the target within the simulative moving image is displayed, and outputs assessment information indicating the result of the assessment of the risk.

IPC Classes  ?

• G09B 9/052 - Simulators for teaching or training purposes for teaching control of vehicles or other craft for teaching control of land vehicles characterised by provision for recording or measuring trainee's performance
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• G06T 7/00 - Image analysis
• G09B 19/00 - Teaching not covered by other main groups of this subclass

Abstract

A rotary mechanism 8 rotates a main shaft 2a on which a cutting tool 10 or material 6 to be worked is mounted. A rotation control unit 21 controls the rotation of the main shaft 2a by the rotary mechanism 8. A feed mechanism 7 moves the cutting tool 10 relative to the material 6 to be worked. The rotation control unit 21 alternately executes acceleration control to accelerate the rotation of the main shaft so that a speed change ratio, which is the ratio of the current cutting speed and the cutting speed of the previous revolution at the same rotational position, is higher than or equal to a first value greater than 1 and deceleration control to decelerate the rotation of the main shaft so that the speed change ratio is lower than or equal to a second value less than 1.

IPC Classes  ?

• B23Q 15/12 - Adaptive control, i.e. adjusting itself to have a performance which is optimum according to a preassigned criterion
• B23B 1/00 - Methods for turning or working essentially requiring the use of turning-machinesUse of auxiliary equipment in connection with such methods

Abstract

The present invention addresses the problem of providing an anti-ROR1 monoclonal antibody that is taken in a cancer cell with ROR1 during endocytosis of the cancer cell. This problem can be solved by an anti-ROR1 monoclonal antibody that recognizes the amino acid sequence from position 156 to 300 of human ROR1 protein (GenBank accession No. NP_005003.2) as an epitope.

IPC Classes  ?

• C12N 15/13 - Immunoglobulins
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 35/00 - Antineoplastic agents
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/46 - Hybrid immunoglobulins
• C12P 21/08 - Monoclonal antibodies

IPC Classes  ?

• A01C 1/00 - Apparatus, or methods of use thereof, for testing or treating seed, roots, or the like, prior to sowing or planting
• A01G 22/22 - Rice

Abstract

[Problem] To provide a rice plant production method that increases rice plant yield and improves rice quality. [Solution] This rice plant production method includes: an aqueous solution preparation step for preparing an aqueous solution that contains L-sodium lactate; a plasma radiation step for radiating atmospheric-pressure plasma at the aqueous solution to produce a plasma-activated aqueous solution; and an aqueous solution supply step for supplying the plasma-activated aqueous solution to a rice plant growth point GP1. The rice plant production method also involves directly radiating atmospheric-pressure plasma toward the rice plant growth point GP1.

IPC Classes  ?

• A01G 22/22 - Rice
• A01G 7/04 - Electric or magnetic treatment of plants for promoting growth
• C02F 1/48 - Treatment of water, waste water, or sewage with magnetic or electric fields
• H05H 1/24 - Generating plasma

Abstract

the total number of amino acid residues is 100 or less.

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61P 35/00 - Antineoplastic agents
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

In a method for analyzing samples involving the use of a device for analyzing samples, the device for analyzing samples includes at least a movement part through which a sample moves, and a measurement unit that is formed in a middle of the movement part and that measures a value of an ion current when the sample passes through the movement part. The analysis method includes at least a measurement step for measuring the value of the ion current when the sample passes through the movement part, and a determination step for determining a change over time in a quantity of ions from the value of the ion current measured in the measurement step. The quantity of ions includes a quantity of ions that have leaked from the sample during movement of the sample through the movement part.

IPC Classes  ?

• G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials
• G01N 27/447 - Systems using electrophoresis
• G01N 15/10 - Investigating individual particles
• G01N 27/327 - Biochemical electrodes

Abstract

E. coli expression system or a yeast expression system, a target protein is expressed as a tag-added protein to which a peptide tag composed of an amino acid sequence SK, SKX, SKXX (SEQ ID NO. 1), AKXX (SEQ ID NO. 29), or KKXX (SEQ ID NO. 30) (wherein X represents any amino acid residue) is linked at the N-terminal.

IPC Classes  ?

• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C12P 21/00 - Preparation of peptides or proteins

Abstract

In the present invention, a non-covalent nanocarbon-polymer hybrid composition, which contains a polymer having a non-covalent functional group and a nanocarbon having a non-covalent functional group, is employed to provide a material obtained by direct and homogeneous mixing at the molecular level of the polymer and the nanocarbon, without utilizing the surfactant effect exhibited by a dispersing agent even when a solvent or a dispersing agent is not substantially used.

IPC Classes  ?

• C08L 101/02 - Compositions of unspecified macromolecular compounds characterised by the presence of specified groups
• C08J 3/205 - Compounding polymers with additives, e.g. colouring in the presence of a liquid phase
• C08K 3/04 - Carbon

Abstract

The present disclosure provides a technique for decomposing an oil or fat containing a trans-fatty acid. A novel lipase according to the present disclosure has an activity to decompose an oil or fat containing a trans-fatty acid. The lipase according to the present disclosure comprises a polypeptide comprising an amino acid sequence represented by SEQ ID NO: 4, 11, 16 or 18, or a polypeptide encoded by a nucleotide sequence represented by SEQ ID NO: 1, 7, 15 or 17, or a polypeptide having at least 70% sequence homology with the above-mentioned polypeptides. The lipase has an ability to decompose an oil or fat even at a high temperature, and is found to have excellent thermal stability. The lipase according to the present disclosure is useful for an oil treatment, such as the treatment of wastewater, a detergent, and a technique for modifying a fat or for producing an oil or fat.

IPC Classes  ?

• C12N 15/55 - Hydrolases (3)
• C02F 1/00 - Treatment of water, waste water, or sewage
• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used
• C11D 3/386 - Preparations containing enzymes
• C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 9/20 - Triglyceride splitting, e.g. by means of lipase

Abstract

The present invention provides novel microorganisms that can decompose oil and fat. In one embodiment, the microorganism is in the family Burkholderia. In one embodiment, the microorganism is in the genus Burkholderia. In one embodiment, the microorganism is Burkholderia arboris, a Burkholderia cepacia complex, etc. In one embodiment, the microorganism according to the present invention has the ability to assimilate a trans fatty acid. In one embodiment, the microorganism according to the present invention has the ability to decompose a trans fatty acid. In one embodiment, the microorganism according to the present invention has the ability to decompose oil and fat containing a trans fatty acid. In one embodiment, the microorganism according to the present invention has the ability to assimilate oil and fat containing a trans fatty acid.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used

Abstract

The present invention provides an antisense oligonucleotide that induces tau exon 10 skipping, the oligonucleotide including a nucleotide sequence that comprises the nucleotide sequence represented by sequence no. 44 and is complementary with a sequence comprising at least 10 continuous nucleotides in a region within exon 10 of a tau mRNA precursor, and the oligonucleotide including at least one 2'-O, 4'-C-ethylene-bridged nucleic acid. The present invention also provides an antisense oligonucleotide that suppresses tau exon 10 skipping, the oligonucleotide including a nucleotide sequence that comprises the nucleotide sequence represented by sequence no. 45 and is complementary with a sequence comprising at least 10 continuous nucleotides in a region within intron 10 of a tau mRNA precursor, and the oligonucleotide including at least one 2'-O, 4'-C-ethylene-bridged nucleic acid.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
• A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

−3.

IPC Classes  ?

• H01L 29/868 - PIN diodes
• C23C 16/32 - Carbides
• C30B 25/20 - Epitaxial-layer growth characterised by the substrate the substrate being of the same materials as the epitaxial layer
• C30B 29/36 - Carbides
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 21/205 - Deposition of semiconductor materials on a substrate, e.g. epitaxial growth using reduction or decomposition of a gaseous compound yielding a solid condensate, i.e. chemical deposition

Abstract

The disclosure provides a heat conduction structure with higher heat conductivity. This embodiment is a heat conduction structure where heat is conducted from a first member to a second member. The heat conduction structure includes at least one self-assembled monolayer and a heat dissipation grease. The self-assembled monolayer is formed on at least one surface of the first member and the second member. The heat dissipation grease is disposed between the first member and the second member. The heat dissipation grease is in contact with the self-assembled monolayer.

IPC Classes  ?

• H01L 23/34 - Arrangements for cooling, heating, ventilating or temperature compensation
• H01L 23/42 - Fillings or auxiliary members in containers selected or arranged to facilitate heating or cooling

Abstract

A viewpoint recommendation apparatus includes image feature extraction means for extracting an image feature from the acquired image at a first viewpoint, pose estimation means for calculating a first likelihood map indicating a relation between the estimated pose of the object and a likelihood of this estimated pose, second storage means for storing a second likelihood map indicating a relation between the true first viewpoint and a likelihood of this first viewpoint in the estimated pose, third storage means for storing a third likelihood map indicating a relation between the pose of the object when the object is observed at the first and the second viewpoints and a likelihood of this pose, and viewpoint estimation means for estimating the second viewpoint so that a value of an evaluation function of the first, second, and third likelihood maps becomes the maximum or minimum.

IPC Classes  ?

• G06T 7/70 - Determining position or orientation of objects or cameras
• G06T 7/00 - Image analysis
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G06N 20/00 - Machine learning
• G06F 17/18 - Complex mathematical operations for evaluating statistical data

Abstract

The method for assisting diagnosis of three major neurodegenerative diseases consisting of Alzheimer's disease, Parkinson's disease, and ALS provided by the present invention includes: obtaining a mass spectrum of a specimen collected from a subject by (MALDI/TOF-MS); and judging the subject to be positive or negative with respect to the three major neurodegenerative diseases on the basis of the magnitude of peak values at a mass-to-charge ratio (m/z) of the resulting mass spectrum of m/z=1733±1 and m/z=2399±1 or a prescribed peak information value derived from the peak values.

IPC Classes  ?

• G16C 20/70 - Machine learning, data mining or chemometrics
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• H01J 49/00 - Particle spectrometers or separator tubes
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis

Abstract

The present invention addresses the problem of providing: a chimeric antigen receptor that has improved safety and is suitable for clinical applications; and the use of the chimeric antigen receptor. Disclosed is a CD37-specific chimeric antigen receptor having an antigen recognition level that is controlled by adjustment of a spacer domain thereof.

IPC Classes  ?

• C07K 16/46 - Hybrid immunoglobulins
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 19/00 - Hybrid peptides
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12N 15/13 - Immunoglobulins
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms

Abstract

3, in which A and B are each a cation and X is an anion, and an emission element is located at a B site serving as a body center of the perovskite crystal structure.

IPC Classes  ?

• C09K 11/77 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing rare earth metals

Abstract

The present invention relates to methods for depositing vertically oriented carbon nanowalls (CNWs) using non-equilibrium gases such as gaseous plasma. Methods are disclosed for rapid deposition of uniformly distributed nanowalls on large surfaces of substrates using ablation of bulk carbon materials by reactive gaseous species, formation of oxidized carbon-containing gaseous molecules, ionization of said molecules and interacting said molecules, neutral or positively charged, with a substrate. The CNWs prepared are useful in different applications such as fuel cells, lithium ion batteries, photovoltaic devices and sensors of specific gaseous molecules.

IPC Classes  ?

• C01B 32/18 - NanoonionsNanoscrollsNanohornsNanoconesNanowalls
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures
• H01M 4/00 - Electrodes

Abstract

A device equipped with a heat generator and a heat exchanger which has an evaporator that absorbs heat from the heat generator and causes an operating fluid to evaporate from a liquid phase to a gas phase, and which condenses the gas-phase operating fluid flowing from the evaporator and circulates the resulting liquid-phase operating fluid to the evaporator, said device characterized in that the evaporator has an evaporative body which has an inner space into which the liquid-phase operating fluid flows, a plurality of holes which guide the liquid-phase operating fluid in the space to the outer surface of the evaporative body by means of capillary force and causes the liquid-phase operating fluid to evaporate, and, on the outer surface, a plurality of evaporative body grooves for guiding the evaporated operating fluid, the evaporator also having a storage body, which accommodates the evaporative body and the inner surface of which supports the outer surface of the evaporative body, and the inner surface of the storage body has a plurality of first storage body grooves extending in a direction intersecting the evaporative body grooves and having a smaller width than the evaporative body grooves and a plurality of second storage body grooves extending in a direction intersecting the first storage body grooves and having a smaller width than the evaporative body grooves.

IPC Classes  ?

• F28D 15/04 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes with tubes having a capillary structure
• F28D 15/02 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes
• H01L 23/427 - Cooling by change of state, e.g. use of heat pipes
• H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating

Abstract

In the present invention, a setting unit 3 sets a sonic stimulus. A sound generation unit 4 generates the set sonic stimulus. The setting unit 3 sets a sonic stimulus that activates a vestibular organ of a subject through the otolith, and that has a sound level value between 70 and 85 decibels and a frequency between 20 and 140 hertz. An information acquisition unit 5 acquires information pertaining to the vestibular organ of the subject, and the setting unit 3 sets at least one among the sound level and the frequency of the sonic stimulus according to the acquired information pertaining to the vestibular organ.

IPC Classes  ?

• A61F 11/00 - Methods or devices for treatment of the ears or hearing sense Non-electric hearing aidsMethods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing senseProtective devices for the ears, carried on the body or in the hand

Abstract

The present invention provides a sugar-responsive gel that is highly resistant to temperature changes, and a sugar-responsive drug delivery device including such a gel. The sugar-responsive gel, which comprises a gel composition including a monomer having a hydroxyl group in addition to a phenylboronic-acid-based monomer, can exhibit suitable temperature resistance. A sugar-responsive drug delivery device including such a sugar-responsive gel is less susceptible to the effects of temperature changes, and therefore can prevent undesirable excessive delivery of a drug (such as insulin) even if the body temperature of a patient wearing the device has dropped for any reason.

IPC Classes  ?

• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 38/28 - Insulins
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

A force-sense visualization apparatus includes a data acquisition unit configured to acquire image data and force-sense data, image data being obtained by taking an image of a surrounding environment of a robot, the force-sense data relating to a force sense that the robot has received from the outside, a conversion unit configured to convert the force sense into text information composed of onomatopoeia based on the force-sense data, and an image output unit configured to superimpose the text information on the image of the image data and output the resultant image data.

IPC Classes  ?

• G06F 3/048 - Interaction techniques based on graphical user interfaces [GUI]
• B25J 9/16 - Programme controls
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

The purpose of the present invention is to provide a living body seating detection device which can obtain exact seating determination accuracy regardless of the differences between individual living bodies. The living body seating detection device (10) of the present embodiment is provided with: a load detection unit (20) which includes a load sensor (30) having a single crystal load detection element (32) to which a portion of the load received by a seating part (14) of a seat (12) is added; and a seating determination means (70) which determines that an object on the seating part (14) of the seat (12) is a living body on the basis that a signal derived from the activity of the living body exists in a load signal (SW) showing the load detected by the load sensor (30). By means of the above configuration, the object on the seating part (14) on the seat (12) is determined by the seating determination means (70) to be the living body on the basis that the signal derived from the activity of the living body exists in the load signal (SW) output from the load sensor (30) which has high frequency characteristics, and therefore exact seating determination accuracy can be obtained.

IPC Classes  ?

• B60N 2/90 - Details or parts not otherwise provided for
• A47C 7/62 - Accessories for chairs
• A61B 5/117 - Identification of persons

Abstract

Provided is an abnormality detection device for detecting an abnormality from an acoustic signal that is produced by a generating device and is accompanied by a state change. The abnormality detection device comprises a pattern storage unit, first extended-time-feature extraction unit, pattern feature calculation unit, and score calculation unit. The pattern storage unit stores a signal pattern model learned on the basis of a first time range of an acoustic signal for learning and an extended-time feature value for learning calculated from a second time range of the acoustic signal for learning longer than the first time range. The first extended-time-feature extraction unit extracts an extended-time feature value for abnormality detection that corresponds to the extended-time feature value for learning from an acoustic signal from an object of abnormality detection. The pattern feature calculation unit calculates a signal pattern feature relating to the acoustic signal from the object of abnormality detection on the basis of the acoustic signal from the object of abnormality detection, the extended-time feature value for abnormality detection, and the signal pattern model. The score calculation unit uses the signal pattern feature to calculate an abnormality score for detecting an abnormality in the acoustic signal from the object of abnormality detection.

IPC Classes  ?

• G01H 17/00 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves, not provided for in the other groups of this subclass
• G01M 99/00 - Subject matter not provided for in other groups of this subclass

Abstract

The present invention addresses the problem of providing a compound having a β-lactamase inhibitory activity. The problem is solved by a compound which is represented by general formula (1) that represents a compound in which a specific location of a 5-membered ring having flatness is substituted with a sulfamoyl group and a carboxyl group.

IPC Classes  ?

• A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 31/04 - Antibacterial agents
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07D 207/36 - Oxygen or sulfur atoms
• C07D 307/68 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

The present invention provides a block copolymer composition comprising a block copolymer (B) obtained by introducing a noncovalently bondable functional group to a block copolymer (A) which has at least one aromatic vinyl polymer block and at least one conjugated diene polymer block, wherein the block copolymer (B) has an ionic group as the noncovalently bondable functional group.

IPC Classes  ?

• C08F 8/46 - Reaction with unsaturated dicarboxylic acids or anhydrides thereof, e.g. maleinisation
• C08F 8/32 - Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
• C08F 8/44 - Preparation of metal salts or ammonium salts
• C08F 287/00 - Macromolecular compounds obtained by polymerising monomers on to block polymers

Abstract

1 when 0

IPC Classes  ?

• H01L 35/16 - Selection of the material for the legs of the junction using inorganic compositions comprising tellurium or selenium or sulfur
• C01B 33/06 - Metal silicides
• C22C 27/02 - Alloys based on vanadium, niobium or tantalum
• C30B 29/52 - Alloys
• C30B 29/62 - Whiskers or needles
• H01L 35/32 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof operating with Peltier or Seebeck effect only characterised by the structure or configuration of the cell or thermocouple forming the device

Abstract

An actuator device (10) is provided with an actuator member (230) which deforms according to the temperature thereof to change the position of a body (220) to be driven, a temperature adjustment member (231) which adjusts the temperature of the actuator member, a temperature acquisition unit (110) which acquires the temperature of the actuator member, and a control unit (120) which controls the temperature adjustment by the temperature adjustment member. The control unit controls, on the basis of the temperature of the actuator member acquired by the temperature acquisition unit, the temperature adjustment by the temperature adjustment member.

IPC Classes  ?

• H02N 10/00 - Electric motors using thermal effects
• F03G 7/00 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for
• H02N 11/00 - Generators or motors not provided for elsewhereAlleged perpetua mobilia obtained by electric or magnetic means

Abstract

A heat storage reactor, comprising: a plurality of heat storage layers including first flow paths through which a first fluid can flow, each of the first flow paths being filled with heat storage materials; and a plurality of heat exchange layers including second flow paths through which a second fluid can flow. In the heat storage reactor, the plurality of heat storage layers and the plurality of heat exchange layers are alternately stacked. Further, open ends for the second flow paths are formed on a surface different from a surface on which open ends of the first flow paths are formed. Furthermore, at least a part of the second flow paths is formed in parallel to the first flow paths.

IPC Classes  ?

• F28D 17/00 - Regenerative heat-exchange apparatus in which a stationary intermediate heat-transfer medium or body is contacted successively by each heat-exchange medium, e.g. using granular particles
• F28D 17/04 - Distributing arrangements for the heat-exchange media
• F28D 17/02 - Regenerative heat-exchange apparatus in which a stationary intermediate heat-transfer medium or body is contacted successively by each heat-exchange medium, e.g. using granular particles using rigid bodies, e.g. of porous material

Abstract

The atomic beam generation device 10 comprises: a cathode 20 in the form of a case having an emission surface 22 with an irradiation opening 23 through which an atomic beam can be emitted; an anode 40 disposed inside the cathode 20 and generating a plasma with the cathode 20; and magnetic field generation units 61, 62 comprising a first magnetic field generation unit 61 for generating a first magnetic field B1 and a second magnetic field generation unit 62 for generating a second magnetic field B2, wherein the first magnetic field and the second magnetic field are generated inside the cathode 20 in parallel to the emission surface 22 such that the orientation of the first magnetic field is in the leftward direction and the orientation of the second magnetic field is in the rightward direction when viewed from the emission surface 22 side with the first magnetic field being positioned above the second magnetic field, and cations generated inside the cathode 20 are guided to the emission surface.

IPC Classes  ?

• H05H 3/02 - Molecular or atomic-beam generation, e.g. resonant beam generation
• G21K 1/14 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating using charge exchange devices, e.g. for neutralising or changing the sign of the electrical charges of beams
• H05H 1/24 - Generating plasma

Abstract

Provided is a novel method for decomposing an organic substance such as a ligneous material or a synthetic polymer. This method for decomposing an organic substance is characterized in that there are used a catalyst in which a complex formed from a transition metal and a pi-electron-containing organic ligand is supported on an electroconductive material or a semiconductor, and an oxidizing agent.

IPC Classes  ?

• B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless
• B01J 31/22 - Organic complexes
• C08J 11/10 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation

Abstract

Provided is a radius end mill in which chattering vibration is suppressed to improve machining stability. A radius end mill (1) is provided with a circular arc edge (5) provided on the outer peripheral side of the front end (4) of the tool body (3). In a longitudinal cross-section including the center axis of the tool body (3), a nose (R) angle (θr) which defines an angular range in which the circular arc edge (5) is formed is set to be 30º or less. In the longitudinal cross-section, the circular arc edge (5) is formed as a circular arc edge for bottom surface, which extends to a side surface (4b) from a position (P1) which is located on the bottom surface (4a) of the front end (4) of the tool body (3) and through which a tangential line in a direction perpendicular to the center axis passes. A nose (R) height (Hr) which is the dimension of the circular arc edge (5) in the direction of the center axis is set to be 0.75 mm or less.

IPC Classes  ?

• B23C 5/10 - Shank-type cutters, i.e. with an integral shaft

Abstract

The present invention relates to fused cyclic urea derivatives which have antagonistic activities against CRHR1 and/or CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR1 and/or CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CRHR1 and/or CRHR2 is involved.

IPC Classes  ?

• C07D 235/26 - Oxygen atoms
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/4725 - Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/5383 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• C07D 471/04 - Ortho-condensed systems
• C07D 487/04 - Ortho-condensed systems
• C07D 491/107 - Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
• C07D 498/04 - Ortho-condensed systems

Abstract

Provided is an endoscope observation assistance device, and the like, which has higher endoscope observation assisting performance and enables doctors to observe a lesion more easily and accurately. This endoscope observation assistance device (100) is provided with: an image information acquisition unit (31) for acquiring images of a lumen organ captured by an endoscope device (40) and displaying the captured images on a display unit (22); a lesion information acquisition unit (32) for detecting a predetermined lesion on the basis of the captured images and acquiring lesion information relating to the lesion; a lesion disappearance determination unit (34) for tracking the lesion on the basis of the captured images and the lesion information and determining whether the lesion has disappeared in a captured image or not; and a notification unit (35) which, when the lesion disappearance determination unit (34) has determined that the lesion has disappeared in a captured image, reports the determination result. The notification unit (35) may report detection of a lesion by the lesion information acquisition unit (32) after the passage of a very short time after the detection.

IPC Classes  ?

• A61B 1/045 - Control thereof
• G02B 23/24 - Instruments for viewing the inside of hollow bodies, e.g. fibrescopes

Abstract

Provided is a method, a device and a kit for detecting childhood cancer, predicting the risk of childhood cancer, determining the stage of the childhood cancer, determining the prognosis of the childhood cancer, and/or monitoring the effect of a treatment for the childhood cancer in a subject by measuring ae urinary metabolite of the subject.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A production device 10 for fiber-reinforced thermoplastic resin comprising: an impregnation chamber for impregnating a thermoplastic resin monomer liquid or solution into a plurality of long fibers 20; a polymerization chamber 11 for polymerizing the monomer by heating the long fibers 20 that are impregnated with the monomer; and a moving unit 16 for drawing the long fibers 20 impregnated with the thermoplastic resin from the chamber.

IPC Classes  ?

• B29B 15/12 - Coating or impregnating of reinforcements of indefinite length
• C08G 69/16 - Preparatory processes
• B29K 77/00 - Use of polyamides, e.g. polyesteramides, as moulding material
• B29K 105/08 - Condition, form or state of moulded material containing reinforcements, fillers or inserts of continuous length, e.g. cords, rovings, mats, fabrics, strands or yarns

Abstract

A production method for a molded article of fiber-reinforced thermoplastic resin, comprising: a step in which a first fiber-reinforced thermoplastic resin base material produced by melt-kneading and extruding thermoplastic resin and fibers and a second fiber-reinforced thermoplastic resin base material produced by impregnating thermoplastic resin in fibers are mixed; a step in which the mixed first and second fiber-reinforced thermoplastic resin base materials are heated; and a step in which the heated first and second fiber-reinforced thermoplastic resin base materials are molded. The average value for the length of fibers included in the second fiber-reinforced thermoplastic resin base material is greater than the average value for the length of fibers included in the first fiber-reinforced thermoplastic resin base material.

IPC Classes  ?

• B29C 70/10 - Fibrous reinforcements only characterised by the structure of fibrous reinforcements
• B29C 70/40 - Shaping or impregnating by compression
• C08J 5/04 - Reinforcing macromolecular compounds with loose or coherent fibrous material

Abstract

A first chamber (100) has a target housing section (110) for housing a target (T1). A second chamber (200) has a substrate support section (210) for supporting a substrate (S1). A partition part (300) has: a cylindrically-shaped section (330); and an opening member (340) which covers a first open end (331) of the cylindrically-shaped section (330) and which also has a plurality of through-holes (341) connecting the first chamber (100) and the second chamber (200). The target housing section (110) is disposed at a position opposite to the substrate support section (210). The opening member (340) is disposed at a position between the target housing section (110) and the substrate support section (210).

IPC Classes  ?

• C23C 14/34 - Sputtering

Abstract

The present invention addresses the problem of providing a novel evaluation system that is useful particularly in studying the onset mechanism and pathological conditions of a central nervous system disease or developing a therapeutic method therefor. The drug efficacy of a test substance is evaluated with the use of a movement pattern, said movement pattern being specified by the movement variation of individual cells constituting a cell population, as an indicator.

IPC Classes  ?

• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12N 5/0793 - Neurons
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

Abstract

A phosphole compound represented by the formula 3 are the same or different, and represent a hydrogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group; and Z represents a reactive group) can provide a fluorescent dye capable of maintaining a high fluorescence quantum yield irrespective of solvent polarity, and providing an improved fluorescence quantum yield and light resistance even in environments containing large amounts of water.

IPC Classes  ?

• C09B 57/00 - Other synthetic dyes of known constitution
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• C07F 9/6568 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
• A61K 49/00 - Preparations for testing in vivo

Abstract

The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• A61K 49/00 - Preparations for testing in vivo
• C08B 37/16 - CyclodextrinDerivatives thereof
• C09B 23/01 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain
• C09B 23/08 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups more than three CH groups, e.g. polycarbocyanines
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/026 - Measuring blood flow
• A61B 5/20 - Measuring urological functions
• A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
• C09B 67/00 - Influencing the physical, e.g. the dyeing or printing, properties of dyestuffs without chemical reaction, e.g. by treating with solventsProcess features in the making of dyestuff preparationsDyestuff preparations of a special physical nature, e.g. tablets, films
• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution

Abstract

The present invention addresses the problem of providing an embedding agent whereby it becomes possible to reduce background in a specimen sectioned from a frozen block when the specimen is dyed. The problem can be solved by an embedding agent for frozen section production use, which comprises a freezing and embedding agent and synthetic collagen.

IPC Classes  ?

• G01N 1/36 - Embedding or analogous mounting of samples
• G01N 1/28 - Preparing specimens for investigation

Abstract

This heat exchanger 18 is provided with: a low temperature side flow path 32 in which liquid helium at a low temperature flows; a high temperature side flow path 30 in which liquid helium at a high temperature flows; and a heat transfer part 36 which transfers heat from the high temperature side flow path 30 to the low temperature side flow path 32. The heat transfer part 36 comprises: a partition member which separates the high temperature side flow path 30 and the low temperature side flow path 32 from each other; and a thermal resistance reduction part 40 which reduces the thermal resistance between the partition member and the liquid helium. The thermal resistance reduction part 40 comprises: a porous body that has nanometer-sized pores; and metal fine particles which have a higher thermal conductivity than the porous body.

IPC Classes  ?

• F25B 9/12 - Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point using 3He-4He dilution
• F28F 3/06 - Elements or assemblies thereof with means for increasing heat-transfer area, e.g. with fins, with recesses, with corrugations the means being attachable to the element
• F28F 13/00 - Arrangements for modifying heat transfer, e.g. increasing, decreasing
• F28F 21/08 - Constructions of heat-exchange apparatus characterised by the selection of particular materials of metal

Abstract

The purpose of the present invention is to provide: a novel marker capable of predicting the effects of anti-PD-1 antibody/anti-PD-L1 antibody therapy with high sensitivity; and a use thereof. Provided is a biomarker for predicting the effects of anti-PD-1 antibody/anti-PD-L1 antibody therapy, the biomarker comprising the immunoglobulin superfamily containing a leucine-rich repeat (ISLR).

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12Q 1/6841 - In situ hybridisation
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

Provided are core-shell-type semiconductor nanoparticles that each have a core and a shell disposed on the surface of the core, and that, upon being irradiated with light, emit light. The core includes a semiconductor that contains M1, M2and Z, wherein: M1includes at least one selected from the group consisting of Ag, Cu, and Au; M2 includes at least one selected from the group consisting of Al, Ga, In and Tl; and Z includes at least one selected from the group consisting of S, Se, and Te. The shell includes a semiconductor that contains a group 13 element and a group 16 element, and that has a greater bandgap energy than the core. The shell has disposed on the surface thereof a compound containing group 15 elements, said group 15 elements at least including P having a negative oxidation number.

IPC Classes  ?

• C09K 11/08 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C01G 15/00 - Compounds of gallium, indium, or thallium
• C09K 11/62 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing gallium, indium or thallium
• C09K 11/64 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing aluminium
• C09K 11/88 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing selenium, tellurium or unspecified chalcogen elements
• H01L 33/50 - Wavelength conversion elements

Abstract

Provided is a method for producing semiconductor nanoparticles that exhibit band-edge emission and have a superior quantum yield. This method for producing semiconductor nanoparticles comprises: raising the temperature of a first mixture containing a salt of Ag, a salt containing In and/or Ga, a solid compound that serves as a source for supplying S, and an organic solvent, to a temperature in the range of 125-175°C; following the raising of the temperature, subjecting the mixture to a thermal treatment at a temperature in the range of 125-175°C for 3 seconds or longer, to obtain a solution containing semiconductor nanoparticles; and, following the thermal treatment, lowering the temperature of the solution containing the semiconductor nanoparticles, wherein the solid compound serving as a source for supplying S contains thiourea.

IPC Classes  ?

• C01G 15/00 - Compounds of gallium, indium, or thallium
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C09K 11/08 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials
• H01L 33/50 - Wavelength conversion elements

Abstract

A drill 10 comprising: a cutting blade 22 formed at the tip of a drill main body; and a chip discard groove 23 having a rake face 24 on the tip side of the drill main body and extending from the rake face 24 towards the rear end side of the drill main body. The drill also comprises a chip guide section 30 provided along the extension direction of the chip discard groove 23 in the rake face 24. The chip guide section 30 has at least one guide groove extending along the extension direction of the chip discard groove 23, from a ridge line at which the cutting blade 22 is provided or the vicinity of the ridge line.

IPC Classes  ?

• B23B 51/00 - Tools for drilling machines
• B23B 51/02 - Twist drills

Abstract

A rotation control unit 11 controls the rotation of a main shaft 2 by a rotation mechanism 10. A movement control unit 13 brings a cutting tool 4 into contact with a workpiece 3 by means of a conveyance mechanism 12 whilst the main shaft 2 is rotating, and performs processing by means of the cutting tool 4. The rotation control unit 11 controls the main shaft rotation speed so as to accelerate or decelerate the rotation of the main shaft 2. The movement control unit 13 brings the cutting tool 4 into contact with the workpiece 3 after the rotation control unit 11 has started the rotation of the main shaft 2, and separates the cutting tool 4 from the workpiece 3 during acceleration control or deceleration control of the main shaft rotation speed by the rotation control unit 11.

IPC Classes  ?

• B23Q 15/12 - Adaptive control, i.e. adjusting itself to have a performance which is optimum according to a preassigned criterion

Abstract

A proton-conductive membrane is provided, which exhibits high proton conductivity even in an anhydrous environment. The proton-conductive membrane includes a crosslinked polymer and a plasticizer, wherein the crosslinked polymer includes a proton acceptor group in an amount equal to not less than 10 mol % of repeating units constituting the crosslinked polymer, the plasticizer includes a proton donor compound having a pKa value of not more than 2.5, and the plasticizer is a viscoelastic solid in a temperature range of 50° C. to 120° C.

IPC Classes  ?

• H01M 8/10 - Fuel cells with solid electrolytes
• H01M 8/1048 - Ion-conducting additives, e.g. ion-conducting particles, heteropolyacids, metal phosphate or polybenzimidazole with phosphoric acid
• H01M 8/1069 - Polymeric electrolyte materials characterised by the manufacturing processes
• H01M 8/1018 - Polymeric electrolyte materials

Abstract

This spatially phase-modulated electron wave generation device which generates spatially phase-modulated electron waves is provided with a laser light output device, a spatial optical phase modulator, and an optical cathode. The optical cathode includes a semiconductor film having an NEA film formed on a surface thereof. The semiconductor film has a thickness smaller than a value obtained by multiplying a coherent relaxation time of electrons in the semiconductor film by the electron transfer rate in the semiconductor film. According to this configuration, a spatial distribution of the phase and a spatial distribution of the intensity of spatially phase-modulated light are transferred to electron waves, and the electron waves emitted from the NEA film are modulated to the spatial distribution of the phase and the spatial distribution of the intensity of the light. Because it is possible to modulate, using the optical spatial phase modulation technology, the spatial distribution of the phase of light as intended, it is possible to generate electron waves in which the spatial distribution of phase has been modulated as intended.

IPC Classes  ?

• H01J 37/073 - Electron guns using field emission, photo emission, or secondary emission electron sources
• G02B 21/32 - Micromanipulators structurally combined with microscopes
• H01J 37/26 - Electron or ion microscopesElectron- or ion-diffraction tubes

Abstract

It is an object to provide a technique useful for embryo transfer and development of reproductive medical care. Provided are a sperm activator containing a disrupted product of one or more cells selected from the group consisting of adipose tissue-derived stem cells, dental pulp-derived stem cells, bone marrow-derived stem cells, and umbilical cord blood-derived stem cells as an active ingredient, and an artificial insemination method utilizing the same.

IPC Classes  ?

• A61K 35/50 - PlacentaPlacental stem cellsAmniotic fluidAmnionAmniotic stem cells
• A61K 35/51 - Umbilical cordUmbilical cord bloodUmbilical stem cells
• A61K 35/52 - SpermProstateSeminal fluidLeydig cells of testes
• A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• A61K 35/32 - BonesOsteocytesOsteoblastsTendonsTenocytesTeethOdontoblastsCartilageChondrocytesSynovial membrane
• A61K 35/54 - OvariesOvaOvulesEmbryosFoetal cellsGerm cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 35/35 - Fat tissueAdipocytesStromal cellsConnective tissues
• A61D 19/00 - Instruments or methods for reproduction or fertilisation
• A61D 19/02 - Instruments or methods for reproduction or fertilisation for artificial insemination
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• C12N 5/076 - Sperm cellsSpermatogonia
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

Provided are: a filter member for capturing extracellular microparticles, said filter member having a simple structure but yet being capable of achieving a high efficiency of capturing extracellular microparticles; a kit for capturing extracellular microparticles using the filter member; and a method for capturing extracellular microparticles using the filter member. The filter member 10 for capturing extracellular microparticles comprises: a plate-shaped filter 11 which is formed of a porous body capable of capturing extracellular microparticles and provided with a first principal surface 11a serving as a filter surface and a second principal surface 11b opposed to the first principal surface 11a; and an elastic member 12 which is disposed in the upper peripheral part of the first principal surface 11a and/or the lower peripheral part of the second principal surface 11b in the state of being elastically contacted with the filter 11.

IPC Classes  ?

• C12M 1/28 - Inoculator or sampler being part of container
• B01D 61/14 - UltrafiltrationMicrofiltration
• B01D 69/06 - Flat membranes
• B01D 69/10 - Supported membranesMembrane supports
• B01D 71/02 - Inorganic material
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/24 - Apparatus for enzymology or microbiology tube or bottle type
• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• G01N 1/04 - Devices for withdrawing samples in the solid state, e.g. by cutting

Abstract

This control device 30 controls the movements of a surgical instrument 5 that is inserted into a body cavity from a port. The surgical instrument 5 is configured to have at least a first link that retains an end effector 13, a second link, and a first joint by which the first link and the second link are connected so as to be capable of relative rotation. A receiving unit 44 receives, from a user, a command operation pertaining to a movement position of a prescribed portion of the first link or the end effector, the movement position being inside the body cavity. A control unit 40 controls the movements of the surgical instrument 5 so that the prescribed portion moves to a command position that corresponds to the position command operation. The control unit 40 calculates the orientation of the first link and the second link on the basis of a movement trajectory of the prescribed portion inside the body cavity until the prescribed portion moves to the command position.

IPC Classes  ?

• A61B 34/35 - Surgical robots for telesurgery
• A61B 34/37 - Leader-follower robots
• B25J 3/00 - Manipulators of leader-follower type, i.e. both controlling unit and controlled unit perform corresponding spatial movements