NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
CELL ENGINEERING CORPORATION (Japan)
Inventor
Soeda Yoshiyuki
Ishigaki Shinsuke
Tachibana Taro
Hayashi Emi
Wang Cai-Xia
Nakatani Naoko
Abstract
The present disclosure provides an antibody that binds to tau aggregates and an antigen-binding fragment of said antibody. Preferably, the antibody and the antigen-binding fragment thereof can selectively bind to tau aggregates rather than to tau monomers.
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
National University Corporation Shiga University of Medical Science (Japan)
Inventor
Saito, Takashi
Harada, Michishige
Shirouzu, Mikako
Matsumoto, Takehisa
Idei, Akiko
Inoue, Jun-Ichiro
Yamamoto, Mizuki
Gohda, Jin
Kawaguchi, Yasushi
Ito, Yasushi
Ishigaki, Hirohito
Nakayama, Misako
Kitagawa, Yoshinori
Abstract
The present invention provides an antibody that binds to an extracellular domain of TMPRSS2, capable of inhibiting beta coronavirus infection of cells, or an antigen-binding fragment thereof, and a composition including the antibody or an antigen-binding fragment thereof.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Yamada, Atsushi
Tani, Tohru
Abstract
Eight traction wires are fastened to fixed recesses of a distal end side cap by enlarged diameter portions, wherein in the distal end side flexible tube, the eight traction wires are arranged in the distal end side upper lumen set in the upward direction HU among the four directions (HU, HD, WR, WL) of the cross section in which lumen sets are provided, and wherein in the base end side flexible tube, the eight traction wires are arranged in the base end side wire lumens which are closer to the cross-sectional center in the upward direction HU than the distal end side upper lumen set and have a wider interval between the arranged traction wires. By towing the traction wires toward the base end side flexible tube, the distal end side flexible tube may be bent and deformed in a desired direction relative to the base end side flexible tube.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Amano, Tsukuru
Murakami, Takashi
Abstract
Provided is a traction tool capable of pulling both sides of a uterus in a single operation. A traction tool 1 of the present invention includes: a pair of holding tools 2, 2; and a coupling tool 3 for coupling the pair of holding tools 2, 2. The traction tool 1 is capable of pulling both sides of a uterus 100 by pulling the coupling tool 3 in a state where both sides of the uterus 100 are held by the pair of holding tools 2, 2.
NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (Japan)
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Fujiwara Koichi
Saeda Shota
Kadotani Hiroshi
Sumi Yukiyoshi
Abstract
An acquisition unit (312) acquires RRI data. A generation unit (314) generates heart rate variability index data on the basis of the RRI data. A first classification unit (318) classifies the heart rate variability index data into a combination of first and second groups, and a third group by inputting the heart rate variability index data to a first algorithm. A second classification unit (320) classifies the heart rate variability index data classified into the combination of first and second groups into the first group and the second group. The first algorithm is trained by using teaching data for the combination of first and second groups, and teaching data for the third group.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Mikata, Saburo
Abe, Takayoshi
Ogita, Hisakazu
Abstract
An electric potential therapy device includes a negative voltage applying means, an electrostatic charge removing means, and a controller that controls the negative voltage applying means and the electrostatic charge removing means in a predetermined therapy time in which a therapy cycle is repeated a plurality of times, the therapy cycle consisting of a first and second period. The negative voltage applying means includes a negative voltage generator and an application electrode. The negative voltage generated by the negative voltage generator is applied to the living body through the application electrode. The controller charges the living body to a negative potential in the first period by controlling the negative voltage applying means to apply the negative voltage to the living body, and puts the living body into a non-charged state by controlling the electrostatic charge removing means to remove electrostatic charges from inside the living body in the second period.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tomonaga, Keizo
Makino, Akiko
Sakai, Madoka
Komorizono, Ryo
Urushitani, Makoto
Morimura, Toshifumi
Minamiyama, Sumio
Abstract
Disclosed are a bornavirus vector comprising a nucleic acid encoding an antibody or antibody fragment capable of binding to a mutant SOD1 protein, the antibody or antibody fragment comprising a heavy-chain variable region comprising a heavy-chain CDR1 consisting of an amino acid sequence GFSLNTSGMG (SEQ ID NO: 1), a heavy-chain CDR2 consisting of an amino acid sequence IWWDDDK (SEQ ID NO: 2), and a heavy-chain CDR3 consisting of an amino acid sequence ARLGYAMDY (SEQ ID NO: 3), the heavy-chain variable region optionally having 3 or fewer amino acid substitutions, and/or a light-chain variable region comprising a light-chain CDR1 consisting of an amino acid sequence ONVGTN (SEQ ID NO: 4), a light-chain CDR2 consisting of an amino acid sequence SAS, and a light-chain CDR3 consisting of an amino acid sequence QQYYIYPYT (SEQ ID NO: 5), the light-chain variable region optionally having 3 or fewer amino acid substitutions; a recombinant virus comprising RNA encoded by the bornavirus vector; a cell infected with the recombinant virus; and a pharmaceutical composition comprising the cell.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani, Tohru
Yamada, Atsushi
Abstract
Provided is a power feeder that has a port site into which a shaft provided with a power receiving unit is inserted, the power feeder making it possible to implement electric current feeding to the power receiving unit at a low cost. A power feeder (1) according to the present invention is capable of bringing ring-side terminals (4A, 4B) and shaft-side terminals (8A, 8B) into contact with each other as a shaft (6) is inserted into a power feeding ring (14) and into a port site (2). When the ring-side terminals (4A, 4B) and the shaft-side terminals (8A, 8B) are in contact with each other, power from a power source is allowed to be fed to a power receiving unit (7) through ring-side power feeding lines (5A, 5B), the ring-side terminals (4A, 4B), the shaft-side terminals (8A, 8B), and shaft-side power feeding lines (9A, 9B).
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Mikata Saburo
Abe Takayoshi
Ogita Hisakazu
Abstract
[Problem] To provide a potential therapy device capable of applying an electrostatic stimulus to cells of a living body and activating the same by negatively charging the living body and then removing the electrostatic charge from the living body. [Solution] A potential therapy device 1 provided with a negative voltage-applying means 2, an electrostatic charge-removing means 3, and a controller 4 for controlling the negative voltage-applying means 2 and electrostatic charge-removing means 3 in a prescribed therapeutic period in which a therapeutic cycle comprising a first period and a second period is repeated multiple times. The negative voltage-applying means 2 is provided with a negative voltage generator 21 and an application electrode 22, and negative voltage generated by the negative voltage generator 21 is applied on a living body P via the application electrode 22. The controller 4 causes the negative voltage-applying means 2 to negatively charge the living body P in the first period by applying the negative voltage on the living body P and, in the second period, causes the electrostatic charge-removing means 3 to remove the electrostatic charge from inside the living body P to put the living body P in an uncharged state.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
ERISA CO.,LTD. (Japan)
Inventor
Shiino Akihiko
Abstract
In the present invention, an acquisition unit 30 acquires: a magnetic resonance imaging (MRI) image that contains, in the subject, the examinee's brain; and the examinee's chronological age. A computation unit 32 computes volume ratios that are the proportion of brain tissue contained in each of a plurality of regions of interest (ROIs) in the MRI image, with respect to total intracranial volume (TIV). A detection unit 33 detects an abnormal ROI, in which the volume ratio of the examinee falls within an abnormal region formed outside a normal region of volume ratios of a group of healthy examinees, which is formed, with respect to an ROI, in a two-dimensional plane with the chronological age being the first axis and the volume ratio being the second axis. An inference unit 34 infers the brain age as the ROI age, the brain age being found from the volume ratio of the examinee and an approximation function of the boundary line between the abnormal region and the normal region in each abnormal ROI. An output unit 36 outputs, as the examinee's brain age, a computed value calculated from each inferred ROI brain age.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Imai, Shinji
Abstract
Provided is a holding instrument for holding a screw placed in a human body, which can hold and remove a screw without damaging a tissue surrounding the screw. In a holding instrument 3 according to the present invention, a cylindrical body 21 moves forward on the shaft 20 tip side while inserting a tip part 26 of a shaft 20 into a hole 4 of a screw 2, thereby exposing a tip part 41 of a projecting member 22 from a groove 31 of the shaft 20. As a result, the holding instrument 3 reaches a state where the tip part 41 of the projecting member 22 and the tip part 26 of the shaft 20 come into firmly contact with the inner peripheral surface of the hole 4 to hold the screw 2 by the holding instrument 3. When the cylindrical body 21 moves backward to the shaft 20 proximal end side to release the firm contact of the tip part 41 of the projecting member 22 and the tip part 26 of the shaft 20 with the inner peripheral surface of the hole 4, the state of the holding instrument 3 is changed from the state where the screw 2 is held by the holding instrument 3 to a state where the screw 2 is removed from the holding instrument 3.
A61B 17/88 - Methods or means for implanting or extracting internal fixation devices
B25B 23/10 - Arrangements for handling screws or nuts for holding or positioning screw or nut prior to or during its rotation using mechanical gripping means
13.
MOVABLE LONG STRUCTURE AND METHOD FOR MANIPULATING SAME, MEDICAL SYSTEM, TOOL, ROBOT AND METHOD FOR OPERATING SAME, MANIPULATOR, FLEXIBLE ENDOSCOPE, AND STEERING CATHETER
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Yamada Atsushi
Tani Tohru
Abstract
The purpose of the present invention is to provide, inter alia, a movable long structure in which it is possible to bend and deform at least the distal-end side in a desired direction using a simple structure. Eight traction wires 50 are latched, in an expanded-diameter part 51, to a fixation recess 61 of a distal-end cap 60. In a distal-end-side flexible tube 20, the traction wires 50 are routed in a distal-end-side upper lumen group 23 on the upward-direction HU side from among four directions (HU, HD, WR, WL) of a cross-section provided with lumen groups 23, 24, 25, 26. In a base-end-side flexible tube 30, the traction wires 50 are routed in base-end-side wire lumens 35b, 36a for which the spacing between routed traction wires 53a, 53b is greater and the distance from the cross-section center 0 in the upward direction HU is lower than in the distal-end-side upper lumen group 23. Therefore, pulling the traction wires 53a, 55b toward the base-end side LB makes it possible to bend and deform the distal-end-side flexible tube 20 in a desired direction relative to the base-end-side flexible tube 30.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
NIPRO CORPORATION (Japan)
Inventor
Tani, Tohru
Yamada, Atsushi
Hiejima, Katsuhiro
Saito, Yoshikazu
Abstract
Provided is a soft endoscope of a new structure which enables single use by reducing the number of parts and simplifying the structure, and makes it possible to reduce the burden of washing and sterilization before reuse. The soft endoscope 10 comprises: a shaft 12 which has lumens 18, 20 that penetrate in a length direction; a distal end chip 14 which is provided in a distal end side of the shaft 12; an imaging device 42 which acquires an image of the distal end side; a light source 44 which projects light towards the distal end side; electric wiring 22 which extends into the lumen 18 of the shaft 12 and is connected to the imaging device 42 and the light source 44; a curved movable unit 28 which is provided at a distal end portion of the shaft 12 and for which bending deformation is allowed; and an operation wire 34 which extends into the lumen 20 of the shaft 12, is fixed at the distal end of the curved movable unit 28, and makes it possible to control bending deformation of the curved movable unit 28 by means of an external operation force, wherein the entirety of the curved movable unit 28 does not have a frame structure, is configured with a soft flexible tube, and is limited to a single use.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
G02B 23/24 - Instruments for viewing the inside of hollow bodies, e.g. fibrescopes
15.
METHOD FOR PREPARING EFFECTOR CELLS WITH DESIRED SPECIFICITY
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Kawamoto, Hiroshi
Agata, Yasutoshi
Nagano, Seiji
Terada, Koji
Masuda, Kyoko
Kondo, Kenta
Abstract
Provided is a method for producing effector cells expressing a desired specificity determining region. In this method, material cells that have a cassette deck structure with a cassette tape gene comprising a gene encoding a marker protein in their genome, wherein the material cells can be differentiated into the effector cells, and wherein the marker protein can be expressed in the effector cells or progenitor cells thereof when the material cells are differentiated into the effector cells or progenitor cells thereof are provided first. The material cells are proliferated, the proliferated cells are differentiated into the effector cells, and then, the gene encoding the marker protein in the effector cells is exchanged with a gene encoding a protein that contribute the desired specificity.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Yamada, Atsushi
Tani, Tohru
Abstract
A movable elongated structure includes a distal end side tube, a base end side tube, traction wires, and a wiring aid routed by the traction wires arranged between the distal end side tube and the base end side tube, wherein the wiring aid guides the pair of traction wires from a pair of base end side wire lumens provided in the base end side tube to be introduced into a pair of distal end side wire lumens provided in the distal end side tube.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Saito Takashi
Harada Michishige
Shirouzu Mikako
Matsumoto Takehisa
Idei Akiko
Inoue Jun-Ichiro
Yamamoto Mizuki
Gohda Jin
Kawaguchi Yasushi
Ito Yasushi
Ishigaki Hirohito
Nakayama Misako
Kitagawa Yoshinori
Abstract
The present invention provides an antibody that binds to an extracellular domain of TMPRSS2, said antibody being capable of inhibiting the infection of cells by a betacoronavirus. Also provided are an antigen-binding fragment thereof, and a composition comprising the antibody or the antigen-binding fragment.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Imai, Shinji
Abstract
Provided is a surgical instrument that can easily bring the coracoid process into proximity with the scapular neck. A surgical instrument 1 of the present invention includes a shaft 2 extending in the first direction, and an inclined part 3 extending from the tip of the shaft 2 in the second direction. The second direction, in which the inclined part 3 extends, is inclined at an angle of α in a range of 95° or more and 115° or less to the first direction, in which the shaft 2 extends, and the inclined part 3 includes on the outer edge thereof a notch 10 through which a screw is passed.
A61B 17/88 - Methods or means for implanting or extracting internal fixation devices
19.
METHOD FOR IN VITRO PROLIFERATING VIRUS BELONGING TO FAMILY CORONAVIRIDAE, METHOD FOR PRODUCING NEUTRALIZING ANTIBODY TO VIRUS BELONGING TO FAMILY CORONAVIRIDAE, AND METHOD FOR PRODUCING INFECTION MODEL OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Itoh, Yasushi
Ishigaki, Hirohito
Nakayama, Misako
Kitagawa, Yoshinori
Abstract
The present invention addresses the problem of providing a more convenient method for in vitro proliferating a virus belonging to the family Coronaviridae at high proliferation accuracy. This problem is solved by an in vitro virus proliferation method, said method comprising a step for culturing kidney-derived cells, which have been contacted with the virus belonging to the family Coronaviridae, with a use of a cell culture medium to which a protease having an optimum pH of from 7 to 9 is added.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
ERISA CO., LTD. (Japan)
Inventor
Shiino, Akihiko
Abstract
The possibility that an ADNC patient will develop Alzheimer's disease is predicted with high accuracy. A diagnosis assistance device 2 predicts a possibility that a subject who has ADNC will develop Alzheimer's disease within a prescribed period, the diagnosis assistance device 2 comprising a prediction unit 23 that predicts the possibility that the subject will develop Alzheimer's disease within a prescribed period, according to a machine-learned prediction algorithm D4.
G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
21.
METHOD OR AGENT WITH HDAC REGULATOR, FOR TREATMENT OF DIABETES AND COMPLICATIONS
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Kojima, Hideto
Katagi, Miwako
Abstract
The present disclosure provides a novel treatment for diabetes. The present disclosure provides a treatment for diabetes, in which blood sugar control and HDAC adjustment are combined. According to one embodiment, the present disclosure provides a treatment for diabetes and/or diseases, disorders, and/or symptoms related to diabetes, in which blood sugar control and HDAC adjustment are combined. According to one embodiment, blood sugar control and HDAC adjustment are combined to set abnormal stem cells as a target, to treat diabetes and/or diseases, disorders and/or symptoms related to diabetes.
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Urushitani, Makoto
Morimura, Toshifumi
Minamiyama, Sumio
Abstract
Disclosed is an antibody or antibody fragment having binding properties to the mutant SOD1 protein, including: a heavy chain variable region including heavy chain CDR1 composed of an amino acid sequence of GFSLNTSGMG (SEQ ID NO: 1), heavy chain CDR2 composed of an amino acid sequence of IWWDDDK (SEQ ID NO: 2), and heavy chain CDR3 composed of an amino acid sequence of ARLGYAMDY (SEQ ID NO: 3), which may have an amino acid substitution of three or less; and/or a light chain variable region including light chain CDR1 composed of an amino acid sequence of QNVGGTN (SEQ ID NO: 4), light chain CDR2 composed of an amino acid sequence of SAS, and light chain CDR3 composed of an amino acid sequence of QQYYIYPYT (SEQ ID NO: 5), which may have an amino acid substitution of three or less. Also disclosed are: a nucleic acid for encoding the antibody or antibody fragment; a vector containing the nucleic acid; a diagnostic agent and diagnostic kit containing the antibody or antibody fragment; and a pharmaceutical composition containing the antibody or antibody fragment and the nucleic acid or the vector.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tomonaga, Keizo
Makino, Akiko
Sakai, Madoka
Komorizono, Ryo
Urushitani, Makoto
Morimura, Toshifumi
Minamiyama, Sumio
Abstract
Disclosed are: a bornavirus vector capable of binding to a mutant SOD1 protein and carrying a nucleic acid encoding an antibody or antibody fragment, in which the antibody or antibody fragment contains a heavy-chain variable region that may have substitution by 3 or less amino acid residues and comprises a heavy-chain CDR1 comprising the amino acid sequence of GFSLNTSGMG (SEQ ID NO:1), a heavy-chain CDR2 comprising the amino acid sequence of IWWDDDK (SEQ ID NO:2) and a heavy-chain CDR3 comprising the amino acid sequence of ARLGYAMDY (SEQ ID NO:3) and/or a light-chain variable region that may have substitution by 3 or less amino acid residues and comprises a light-chain CDR1 comprising the amino acid sequence of QNVGGTN (SEQ ID NO:4), a light-chain CDR2 comprising the amino acid sequence for SAS and a light-chain CDR3 comprising the amino acid sequence of QQYYIYPYT (SEQ ID NO:5); a recombinant virus which contains RNA encoded in the bornavirus vector; a cell infected by the recombinant virus; and a pharmaceutical composition containing the cell.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Ogita, Hisakazu
Sato, Akira
Ema, Masatsugu
Tsukiyama, Tomoyuki
Abstract
Disclosed are: a hyperlipemia model animal that is a non-human primate in which LDL receptor gene is knocked out; a method for producing a hyperlipemia model animal, the method including introducing a knockout mutation into LDL receptor gene in a fertilized egg generated in the model animal or a non-human primate cell in the model animal; and a method for screening for a candidate substance for a therapeutic drug for hyperlipemia, the method including a step for administering a test substance to the model animal and a step for evaluating the phenotype of hyperlipemia in the model animal to which the test substance has been administered.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
BIOZIPCODE, INC. (Japan)
Inventor
Kojima, Hideto
Terashima, Tomoya
Katagi, Miwako
Abstract
The present disclosure provides a diabetes mellitus therapy targeting abnormal stem cells. In one embodiment, the present disclosure provides a therapy for diabetes mellitus and/or a disease, a disorder and/or a symptom relating to diabetes mellitus, said therapy targeting abnormal stem cells. In one embodiment, the present disclosure provides a diagnosis of diabetes mellitus and/or a disease, a disorder and/or a symptom relating to diabetes mellitus or a risk of the same, said diagnosis using abnormal stem cells as an index. In one embodiment, the abnormal stem cells described in the present disclosure are abnormal hematopoietic stem cells. In one embodiment, CD106 is expressed in the abnormal stem cells described in the present disclosure at a level different from in normal cells.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Hagiwara, Akeo
Tsujimoto, Hiroyuki
Horii, Tsunehito
Isogai, Noritaka
Hagiwara, Kohei
Hagiwara, Yosaku
Abstract
To address the problem of providing a tissue formation agent, the present invention provides a tissue formation agent containing alginic acid or a salt thereof.
National University Corporation Shiga University of Medical Science (Japan)
Inventor
Tani, Tohru
Naka, Shigeyuki
Yamada, Atsushi
Abstract
Provided is a scissors-type medical treatment tool capable of not only local tissue fixation in an incision/cutting part but also heating on side surfaces of electrodes of a forceps/tweezers type. It has been found out that a tissue part in which tissue is nipped between blades and a tissue part which is brought into abutment against side surfaces of the blades can be heated simultaneously or sequentially by optimizing arrangement of microwave application electrodes and microwave receiver electrodes in a blade pair (in particular, by causing coagulation to be performed evenly on the left and right of the blades), and the present invention has therefore been achieved.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
28.
THERAPY FOR DIABETES USING STEM CELL MIGRATION AGENT
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
KOJIMA, HIDETO (Japan)
BIOZIPCODE, INC. (Japan)
Inventor
Kojima, Hideto
Terashima, Tomoya
Katagi, Miwako
Abstract
The present disclosure provides a therapy for diabetes that targets abnormal stem cells in combination with stem cell migration. In one embodiment, the present disclosure provides a therapy for diabetes and/or diabetes-related diseases and disorders and/or symptoms that targets abnormal stem cells in combination with stem cell migration. In one embodiment, the present disclosure provides diagnosis of diabetes and/or diabetes-related diseases and disorders and/or symptoms, or the risk thereof, using abnormal stem cell migration and/or residence as an indicator.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani, Tohru
Abstract
A power supply device in which a device shaft provided with a power receiver is inserted in a through-hole of a port site, which is capable of supplying electric power to the power receiver at a low cost and enabling fine operation of the device shaft. The power supply includes a port site; first terminals provided on an inner surface of the through-hole; wires that connect the first terminals and a power source; a device shaft that is insertable into the through-hole; a power receiver provided on the device shaft; second terminals provided on an outer surface of the device shaft; and wires that connect the power receiver and the second terminals. Electric power from the power supply can be supplied to the power receiver by inserting the device shaft into the through-hole to thereby bring the first terminals and the second terminals into contact with each other.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
30.
Display control device and operation method of display control device
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (Japan)
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Kiuchi, Kunihiko
Ashihara, Takashi
Uchiyama, Kaori
Ota, Akio
Koura, Naoki
Takizawa, Koji
Abstract
A display control device includes processing circuitry configured to: obtain an intracardiac electrocardiogram of a subject; generate visualization data representing an excitation state of a myocardium based on the intracardiac electrocardiogram; determine a type of excitation dynamics of the myocardium based on the visualization data; and display, on a stereoscopic image of a heart of the subject, a site from which the intracardiac electrocardiogram is obtained with a color in accordance with a ratio of the determined type of the excitation dynamics.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Kojima, Hideto
Terashima, Tomoya
Katagi, Miwako
Abstract
The present disclosure provides a therapy for diabetes that targets abnormal stem cells by using an HDAC inhibitor combined with stem cell migration. In one embodiment, the present disclosure provides a therapy for diabetes and/or diabetes-related diseases, disorders and/or symptoms, said therapy targeting abnormal stem cells, by using an HDAC inhibitor combined with stem cell migration. In one embodiment, the present disclosure provides a therapy for diabetes and/or diabetes-related diseases, disorders and/or symptoms, said therapy targeting abnormal stem cells, by using an HDAC inhibitor combined with stem cell migration in a subject having abnormal stem cells detected therein.
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani, Tohru
Naka, Shigeyuki
Yamada, Atsushi
Nakakubo, Tsuyoshi
Abstract
A cutting device including a first contact member and at second contact member assembled so as to be openable and closable, a contact mechanism that rotates the first contact member toward the second contact member to bring the first contact member and the second contact member into contact with a target portion, and a cutting mechanism for cutting the target portion in a state where the first contact member and the second contact member are in contact with the target portion by the contact mechanism.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
ZEON CORPORATION (Japan)
Inventor
Tani, Tohru
Yamada, Atsushi
Shima, Tatsuya
Yonemichi, Wataru
Abstract
A steerable catheter includes a flexible tube having a distal end and a proximal end. The tube includes a first tube section (sheath body section) the flexibility of which does not substantially change even upon receiving compression force in the axial direction; and a second tube section (deflection section) joined so as to be continuous with the distal end of the first tube section and constituted by a porous tube becoming hard upon being compressed according to the degree of the compression force acting in the axial direction and returning to being soft when the compression force is released. The tube includes operation means (wires) for releasably exerting a compression force compressing the second tube section in the axial direction and a deflection force deflecting the second tube section. According to some embodiments, both operability and insertability of the steerable catheter can be improved.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Yamada Atsushi
Tani Tohru
Abstract
[Problem] The purpose of the present invention is to provide a long movable structure having superior attachment properties, a wiring assistance tool that is used in the long movable structure, a long movable structure instrument, etc. [Solution] A spacer 40 comprises a tubular cylinder 42, a base-end-side flange section 43b, and a distal-end-side flange section 43a. The base-end-side flange section 43b is provided with: an approach restriction part 45b that restricts circumferential-direction approach of a pair of traction wires 50, which are drawn out from a pair of base-end-side wire lumens 32 provided to a base-end-side flexible tube 30 and which are led into a pair of distal-end-side wire lumens 22 provided to a distal-end-side flexible tube 20; and a positioning recess 44 in which the traction wires 50 are positioned and which is opened in the radially outer side. The distal-end-side flange section 43a is provided with a separation restriction part 45a that restricts circumferential-direction separation of the traction wires 50, and a positioning recess 44.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Kawamoto, Hiroshi
Agata, Yasutoshi
Nagano, Seiji
Terada, Koji
Masuda, Kyoko
Kondo, Kenta
Abstract
Provided is a method for producing an effector cell expressing a desired specificity site. In this method, material cells capable of differentiating into effector cells are proliferated, the material cells having a cassette deck structure that has cassette tape genes, which include a gene that encodes a marker protein in the genome of the material cells, so as to enable the expression of the marker protein in cells obtained by inducing differentiation of the material cells into effector cells or precursor cells of effector cells. The material cells are then induced to differentiate into effector cells or precursor cells thereof. The marker protein genes included in the resultant effector cells, etc., are replaced with genes encoding a protein contributing to a desired specificity, thereby making it possible to obtain effector cells expressing a desired specificity site.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
NIHON KOHDEN CORPORATION (Japan)
Takeshi Tsuchiya (Japan)
Inventor
Ashihara, Takashi
Takizawa, Koji
Tsuchiya, Takeshi
Abstract
A recording device includes an acquisition unit configured to acquire vital signs through a sensor device having a plurality of electrodes, a recording unit configured to record a bipolar potential of a main channel which is defined by combining the plurality of electrodes, using the vital signs, an addition unit configured to add a mark to each waveform plotted based on variation of the bipolar potential over time, at a predetermined position on a time axis, and an adjusting unit configured to adjust a position of the mark added to each waveform. The adjusting unit is configured to adjust the position of the mark added to the bipolar potential of the main channel, based on bipolar potentials of reference channels including electrodes included in the main channel.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61B 5/287 - Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
37.
THIOREDOXIN INTERACTING PROTEIN EXPRESSION INHIBITOR
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tooyama, Ikuo
Taguchi, Hiroyasu
Yanagisawa, Daijiro
Abstract
Disclosed is a thioredoxin interacting protein (TXNIP) expression inhibitor containing a curcumin derivative represented by formula (I) (In the formula, R12232233O-, R2are each independently a hydrogen atom, or a fluorine atom, A1is a hydrogen atom, or methyl, A2is alkyl, cyano, carboxy, alkoxycarbonyl, or R32mm-, R3is hydroxy, carboxy, cyano, alkylcarbonyloxy, alkoxycarbonyl, alkoxyalkoxy, hydroxyalkoxy, or CONR4R5, R4and R5 are each independently a hydrogen atom, or alkyl, and m is an integer of 1-5), or a salt thereof.
A61K 31/201 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having one or two double bonds, e.g. oleic or linoleic acid
A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 39/06 - Free radical scavengers or antioxidants
A61P 43/00 - Drugs for specific purposes, not provided for in groups
38.
METHOD FOR IN VITRO PROLIFERATING VIRUS BELONGING TO FAMILY CORONAVIRIDAE, METHOD FOR PRODUCING NEUTRALIZING ANTIBODY TO VIRUS BELONGING TO FAMILY CORONAVIRIDAE, AND METHOD FOR PRODUCING INFECTION MODEL OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Itoh, Yasushi
Ishigaki, Hirohito
Nakayama, Misako
Kitagawa, Yoshinori
Abstract
The present invention addresses the problem of providing a more convenient method for in vitro proliferating a virus belonging to the family Coronaviridae at high proliferation accuracy. This problem is solved by an in vitro virus proliferation method, said method comprising a step for culturing kidney-derived cells, which have been contacted with a virus belonging to the family Coronaviridae, with the use of a cell culture medium to which a protease having an optimum pH of from 7 to 9 is added.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Nishi, Eiichiro
Iwasaki, Hirotaka
Ohno, Mikiko
Sato, Yusuke
Harashima, Hideyoshi
Abstract
Disclosed is a metabolism improving agent comprising a carrier which is for delivering liver cells and contains the following (a) or (b): (a) double-stranded RNA having an RNAi effect on nardilysin genes; and (b) DNA that can express double-stranded RNA having an RNAi effect on nardilysin genes.
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Imai, Shinji
Abstract
Provided is a surgical instrument with which it is possible to easily bring a coracoid process close to the scapula and the neck. This surgical instrument comprises a design 2 that extends in a first direction, and an inclined part 3 that extends in a second direction from the distal end of the design 2. The second direction in which the inclined part 3 extends is inclined at an angle α of 95-115 degrees (inclusive) relative to the first direction in which the design 2 extends. A notch 10 through which a screw is passed is formed in the outer edge of the inclined part 3.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Kawamoto, Hiroshi
Agata, Yasutoshi
Nagano, Seiji
Terada, Koji
Masuda, Kyoko
Abstract
Provided is a method for producing a cell incorporating an antigen specific receptor gene, which comprises the step of introducing an exogenous TCR or CAR gene into a material cell so that the introduced gene is expressed under the T cell receptor expression control system of the material cell.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
ERISA CO., LTD. (Japan)
Inventor
Shiino, Akihiko
Abstract
The possibility that an ADNC patient will develop Alzheimer's disease is predicted with high precision. A diagnosis assistance device 2 that predicts the possibility that a test subject having ADNC will develop Alzheimer's disease within a prescribed period, said diagnosis assistance device 2 comprising a prediction unit 23 that predicts, according to a machine-learned prediction algorithm D4, the possibility that the test subject will develop Alzheimer's disease within the prescribed period .
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
ZEON CORPORATION (Japan)
Inventor
Yamada, Atsushi
Tani, Tohru
Yonemichi, Wataru
Shima, Tatsuya
Abstract
Provided is a flange hub provided to a long and narrow body comprising two adjacent long and narrow elements, the flange hub making it possible to adjust, through a simple operation, the orientation of a wire required in order to make the curvature of the long and narrow elements greater at a distal-end side than at a base-end side. In this flange hub, first through-holes 9A, 9B are formed in a distal-end flange 23, and second through-holes 10A, 10B are formed in a base-end flange 24. The first through-holes 9A, 9B are formed at positions for which the shortest distance from a second plane XY is a third distance L3, and the second through-holes 10A, 10B are formed at positions for which the shortest distance from the second plane XY is a fourth distance L4, the third distance L3 being greater than the fourth distance L4.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tooyama, Ikuo
Taguchi, Hiroyasu
Yanagisawa, Daijiro
Kato, Tomoko
Abstract
Disclosed are a diagnostic imaging agent used for detecting oligomeric amyloid-β, with the active ingredient of the diagnostic imaging agent being a curcumin derivative that is present only in a keto form structure or a salt thereof; and a curcumin derivative represented by formula (IA): (in the formula, each R1322332233O-; each R2is independently a hydrogen atom or a fluorine atom; A is alkyl, cyano, carboxy, alkoxycarbonyl, or R32mm-; R3is hydroxy, carboxy, cyano, alkylcarbonyloxy, alkoxycarbonyl, alkoxyalkoxy, hydroxyalkoxy, or CONR4R5; R4and R5are each independently a hydrogen atom or alkyl; and m is an integer of 1-5 (provided that when R1333O-, and R233-)) or a salt thereof.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07C 49/255 - Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
AICHI MEDICAL UNIVERSITY (Japan)
Inventor
Sobue, Gen
Sahashi, Kentaro
Ishigaki, Shinsuke
Endo, Kuniyuki
Fujihara, Tsuyoshi
Neya, Masahiro
Matsuda, Seiji
Abstract
The present invention provides a tau exon 10 skipping-promoting antisense oligonucleotide containing at least one 2′-O, 4′-C-ethylene-bridged nucleic acid, and a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a region consisting of the nucleotide sequence shown in SEQ ID NO: 44 in exon 10 of a tau mRNA precursor. In addition, the present invention provides a tau exon 10 skipping-suppressing antisense oligonucleotide containing at least one 2′-O, 4′-C-ethylene-bridged nucleic acid, and a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a region consisting of the nucleotide sequence shown in SEQ ID NO: 45 in intron 10 of a tau mRNA precursor.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
46.
MEDICAL INSTRUMENT-USE DEFLECTION OPERATION DEVICE
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
ZEON CORPORATION (Japan)
Inventor
Yamada, Atsushi
Tani, Toru
Yonemichi, Wataru
Shima, Tatsuya
Abstract
A medical instrument-use deflection operation device 1A comprises: a first rack member 100 and a second rack member 200 stored in a controller housing 300 so as to be reciprocally displaceable in the longitudinal direction along an extending direction of a first and a second operation wire 31, 32, and also so as to have teeth parts 120, 220 that oppose each other; and a pinion member 400 that is rotatably supported, in a state of engagement with the teeth parts 120, 220 of the rack members 100, 200. A first and a second operation knob 510, 520 that each protrude outward from the controller housing 300 are integrally provided on the rack members 100, 200, respectively.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Teramoto, Kazuo
Ogasawara, Kazumasa
Ueda, Yuji
Abstract
Disclosed are: an immunosuppressive cell-collecting material which includes a molded body having, as an aromatic substituent, a straight-chain aromatic polymer in which nonpolar side-chain amino acid residues are bonded at a ratio of 1-100 per 200 aromatic nuclei through a spacer having a length of 10 or more atoms; and an immunosuppressive cell-collecting column which is filled with said collecting material.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
ZEON CORPORATION (Japan)
Inventor
Yamada, Atsushi
Tani, Tohru
Yonemichi, Wataru
Abstract
A movable catheter is provided with a tube having a main lumen. The tube has a plurality of wire lumens and is provided with a wire. A substantial half on one end portion side thereof is inserted through the wire lumen, an intermediate part thereof is folded back in the distal end portion of the tube, and a substantial half on the other end portion side thereof is inserted through the wire lumen. The one end portion and the other end portion thereof are disposed on the proximal end side of the tube. Various embodiments enable the number of components to be reduced, and to reduce the number of manufacturing steps.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani, Tohru
Abstract
Provided is an electricity supplier in which a device shaft provided with an electricity receiver is inserted in a through-hole of a port site. The electricity supplier can realize, at a low cost, the supply of electric power to the electricity receiver, and enables fine operation of the device shaft. This electricity supplier includes a port site 2; terminals 3A, 3B provided on an inner surface of a through-hole 13 of the port site 2; wires 4A, 4B that connect the terminals 3A, 3B and a power source; a device shaft 5 that is insertable in the through-hole 13 of the port site 2; an electricity receiver 8 provided on the device shaft 5; terminals 6A, 6B provided on an outer surface of the device shaft 5; and wires 7A, 7B that connect the electricity receiver 8 and the terminals 6A, 6B. It is possible to supply electric power from the power source to the electricity receiver 8 by inserting the device shaft 5 in the through-hole 13, thereby causing the terminals 3A, 3B to contact the terminals 6A, 6B.
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Kojima, Hideto
Terashima, Tomoya
Katagi, Miwako
Abstract
The present disclosure provides a diabetes therapy targeting abnormal stem cells. In one embodiment, the present disclosure provides a therapy for diabetes and/or a disease, a disorder and/or a symptom relating to diabetes, said therapy targeting abnormal stem cells. In one embodiment, the present disclosure provides a diagnosis of diabetes and/or a disease, a disorder and/or a symptom relating to diabetes or a risk of the same, said diagnosis using abnormal stem cells as an index. In one embodiment, the abnormal stem cells described in the present disclosure are abnormal hematopoietic stem cells. In one embodiment, CD106 is expressed in the abnormal stem cells described in the present disclosure at a level different from in normal cells.
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 43/00 - Drugs for specific purposes, not provided for in groups
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
51.
THERAPY FOR DIABETES USING STEM CELL MIGRATION AGENT
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Kojima, Hideto
Terashima, Tomoya
Katagi, Miwako
Abstract
The present disclosure provides a therapy for diabetes that targets abnormal stem cells in combination with stem cell migration. In one embodiment, the present disclosure provides a therapy for diabetes and/or diabetes-related diseases and disorders and/or symptoms that targets abnormal stem cells in combination with stem cell migration. In one embodiment, the present disclosure provides diagnosis of diabetes and/or diabetes-related diseases and disorders and/or symptoms, or the risk thereof, using abnormal stem cell migration and/or residence as an indicator.
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Urushitani, Makoto
Tamaki, Yoshitaka
Abstract
A modified antibody fragment comprising an antibody fragment capable of binding to misfolded TDP-43, and a chaperone-mediated autophagy localizing signal peptide.
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
MEDREAM CO., LTD. (Japan)
Inventor
Tooyama, Ikuo
Bellier, Jean-Pierre
Kato, Tomoko
Yokota, Akiho
Abstract
Disclosed is a method for producing rubisco which is derived from plant leaves, the method comprising: (1) a step for heat-treating plant leaves at 50-58°C for 3 minutes to 1 hour; (2) a step for crushing the plant leaves obtained in step (1); (3) a step for removing an insoluble substance from the crushed liquid obtained in step (2); and (4) a step for heat-treating the crushed liquid obtained in step (3) for 5 minutes to 1 hour at 60-100°C, and obtaining agglomerates. Also disclosed are: a method for producing a food or pharmaceutical composition containing rubisco, the method being characterized by using rubisco obtained by said production method; and a food or a pharmaceutical composition which is for promoting serotonin synthesis in the brain and includes the rubisco as an active ingredient.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani, Tohru
Naka, Shigeyuki
Yamada, Atsushi
Abstract
[Problem] To provide a medical treatment tool that has a scissors shape and is capable of not only fixing a local tissue of a cutout/cutoff portion but also heating lateral surfaces of a forceps/pincette-like electrode. [Solution] The present invention has been completed by finding that a tissue portion clamped by blades and a tissue portion in contact with side surfaces of the blades can be simultaneously or successively heated by optimizing (particularly, equalizing solidification of the left and right sides of the blades) the arrangement of a microwave application electrode and a microwave receiving electrode in both the blades.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
55.
CUTTER, FORCEPS, SURGICAL SYSTEM, MEDICAL SYSTEM, ROBOT, MEDICAL ROBOT FOR SURGERY, AND SURGICAL SYSTEM
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani Tohru
Naka Shigeyuki
Yamada Atsushi
Nakakubo Tsuyoshi
Abstract
With the objective of providing a cutter, forceps, a surgical system, a medical system, a robot, a medical robot for surgery, and a surgical system, capable of being brought in contact against (grasping) a target site and cutting the target site in one series of operations, the cutter (1) is constituted in such a manner as to comprise: a first abutting member (14) and a second abutting member (116) assembled to allow for opening and closing; an abutting mechanism (17) rotating the first abutting member (14) toward the second abutting member (116), causing the first abutting member (14) and the second abutting member (116) to be in contact against the target site (B); and a cutting mechanism (10) cutting the target site (B) in a state wherein the abutting mechanism (17) has caused the first abutting member (14) and the second abutting member (116) to be in contact against the target site (B).
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
ZEON CORPORATION (Japan)
Inventor
Tani Tohru
Yamada Atsushi
Shima Tatsuya
Yonemichi Wataru
Abstract
[Problem] To provide a steerable catheter with which both operability and insertability can be improved. [Solution] In a steerable catheter 1, a tube 2 comprises: a first tube section 20 the flexibility of which does not substantially change even upon receiving compression force in the axial direction; and a second tube section 21 that serves as a deflection section constituted by a porous tube which is joined so as to be continuous with a distal end of the first tube section 20, and which hardens upon being compressed according to the degree of compression force acting in the axial direction and returns to being soft when the compression force is released. A hardness adjustment means 6, which adjusts the hardness of the second tube section by releasably pushing the first tube section to a distal end side relative to an operation part 3 provided to the proximal end of the first tube section, is interposed between the proximal end of the first tube section and the operation part.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
ZEON CORPORATION (Japan)
Inventor
Tani Tohru
Yamada Atsushi
Shima Tatsuya
Yonemichi Wataru
Abstract
[Problem] To provide a steerable catheter with which both operability and insertability can be improved. [Solution] A steerable catheter comprises a flexible tube 2 having a distal end and a proximal end. The tube 2 comprises: a first tube section (sheath body section 20) the flexibility of which does not substantially change even upon receiving compression force in the axial direction; and a second tube section (deflection section 21) that is constituted by a porous tube which is joined so as to be continuous with a distal end of the first tube, and which becomes hard upon being compressed according to the degree of compression force acting in the axial direction and returns to being soft when the compression force is released. The tube includes an operation means (wires W1, W2) that releasably exerts a compression force which compresses the second tube section in the axial direction and a deflection force which deflects the second tube section.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Kasuya, Junichi
Matsunaga, Ryo
Ueno, Yoshiyuki
Ueda, Yuji
Teramoto, Kazuo
Ogasawara, Kazumasa
Abstract
An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 μmol and 2500 μmol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 μmol or less per 1 g.
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
NIHON KOHDEN CORPORATION (Japan)
Inventor
Ashihara Takashi
Takizawa Koji
Abstract
A recording device includes: an acquisition unit (102) configured to acquire vital signs through a multi-electrode catheter (X) having a plurality of electrodes; a recording unit (104) configured to record a bipolar potential of a main channel which is defined by combining the plurality of electrodes, using the vital signs; an addition unit (32) configured to add a mark to each waveform plotted based on a potential of the bipolar potential, at a predetermined position on a time axis; and an adjusting unit (33) configured to adjust a position of the mark added to each waveform. The adjusting unit (33) is configured to adjust the position of the mark added to the bipolar potential of the main channel, based on bipolar potentials of reference channels including electrodes included in the main channel.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Morita, Shin-Ya
Abstract
Disclosed is a method for quantifying phosphatidylinositol in a sample, comprising the following step: (1) treating the sample with phospholipase D and inositol dehydrogenase; and a kit for quantifying phosphatidylinositol, containing phospholipase D and inositol dehydrogenase.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Kawamoto, Hiroshi
Agata, Yasutoshi
Nagano, Seiji
Terada, Koji
Masuda, Kyoko
Abstract
Provided are: a method for producing an antigen receptor gene-introduced cell, the method comprising a step for introducing a foreign T cell receptor (TCR) or chimeric antigen receptor (CAR) gene such that expression is accomplished under the control of a TCR expression controlling mechanism of a material cell; and a material cell for introducing a foreign antigen receptor gene having, on a TCR gene locus in the order of, from the upstream side, a promoter sequence in a V-region of the TCR gene locus, a drug-resistant gene or a reporter gene or a known TCR or CAR gene, and an enhancer sequence in a C-region of the TCR gene locus.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Yamada, Atsushi
Tani, Tohru
Naka, Shigeyuki
Morikawa, Shigehiro
Abstract
b is not positioned in a range in which the contact point T is present; and the predetermined straight line X is a line that passes through the axial center G of the guide unit 2, and that orthogonally crosses the extending line Y.
B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewingSafety devices combined with or specially adapted for use in connection with manipulators
63.
DIAGNOSIS SUPPORT DEVICE, MACHINE-LEARNINGING DEVICE, DIAGNOSIS SUPPORT METHOD, MACHINE-LEARNINGING METHOD AND MACHINE-LEARNINGING PROGRAM
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
ERISA CO., LTD. (Japan)
Inventor
Shiino, Akihiko
Abstract
This diagnosis support device (2) is for predicting whether or not a mildly cognitively impaired subject will suffer from an onset of Alzheimer's disease within a predetermined period of time. This diagnosis support device (2) comprises a prediction unit (23) for predicting whether or not the subject will suffer from an onset of Alzheimer's disease within a predetermined period of time, and specifically, for predicting whether an aMCI subject has the progressive pMCI or the non-progressive sMCI, according to a machine-learned prediction algorithm (D4).
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
ZEON CORPORATION (Japan)
Inventor
Yamada, Atsushi
Tani, Tohru
Yonemichi, Wataru
Abstract
[Problem] To enable the number of components to be reduced, and to reduce the number of manufacturing steps. [Solution] A movable catheter 1 is provided with a tube 2 comprising a main lumen 22. The tube 2 comprises a plurality of wire lumens 23a, 23b, and is provided with a wire W1, which has a substantial half section W1a on one end that is inserted into the one wire lumen 23a, an intermediate section W1c that is folded back at a distal end of the tube 2, and a substantial half section W1b on the other end that is inserted into the other wire lumen 23b, both the one end and the other end of the wire being disposed at the proximal end side of the tube 2.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Urushitani, Makoto
Tamaki, Yoshitaka
Abstract
Disclosed is a modified antibody fragment consisting of an antibody fragment capable of binding to misfolded TDP-43 and a chaperone-mediated autophagy transit signal peptide, wherein: the antibody fragment includes a heavy-chain variable region that comprises heavy chain CDR1 comprising the amino acid sequence GFNIKDYY (SEQ ID NO: 1), heavy chain CDR2 comprising the amino acid sequence IDPEDGET (SEQ ID NO: 2) and heavy chain CDR3 comprising the amino acid sequence TIIYYYGSRYVDY (SEQ ID NO: 3), each sequence optionally having not more than 3 amino acid substitutions, and/or a light-chain variable region that comprises light chain CDR1 comprising the amino acid sequence SSISSSY(SEQ ID NO: 4), light chain CDR2 comprising the amino acid sequence RTS and light chain CDR3 comprising the amino acid sequence QQGSSIPLT (SEQ ID NO: 5), each sequence optionally having not more than 3 amino acid substitutions; and the antibody fragment is scFv, VH or VL.
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61P 25/00 - Drugs for disorders of the nervous system
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 43/00 - Drugs for specific purposes, not provided for in groups
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
NATIONAL UNIVERSITY CORPORATION TOYOHASHI UNIVERSITY OF TECHNOLOGY (Japan)
Inventor
Suzuki Asako
Tani Tohru
Naka Shigeyuki
Ohira Takashi
Miyazaki Motoaki
Tsukamoto Satoshi
Sakai Naoki
Abstract
[Problem] To provide an impedance matching circuit capable of being used for a high-power application of several tens of watts or more, and capable of higher-speed impedance matching. [Solution] An impedance matching circuit provided with a variable frequency alternating-current power source is connected to a desired object load, the frequency of the variable frequency alternating-current power source is changed, the trajectory of an output impedance is represented in a spiral form on a Smith chart, and the output impedance is either matched to an impedance being the complex conjugate of the impedance of the object load, or is brought into a desired numerical range. Furthermore, a plurality of frequency ranges in which the output impedance is either matched to the impedance being the complex conjugate of the impedance of the object load, or is brought into the desired numerical range are caused to exist. It is preferable that the impedance being the complex conjugate of the impedance of the object load be plotted in a predetermined place within the whole range on the Smith chart, and that the frequency range in which the frequency of the variable frequency alternating-current power source is changed be a desired frequency range.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Kasuya Junichi
Matsunaga Ryo
Ueno Yoshiyuki
Ueda Yuji
Teramoto Kazuo
Ogasawara Kazumasa
Abstract
The purpose of the present disclosure is to provide an adsorbing material in which the physical strength of a carrier material is maintained and immunosuppressive proteins are efficiently adsorbed. The present disclosure provides an immunosuppressive-protein-adsorbing material that includes a water-insoluble carrier to which is bonded one or more nitrogen-containing compounds selected from polyamines represented by a prescribed formula and aliphatic amines represented by a prescribed formula, the total amount of amino groups on the water-insoluble carrier being greater than 0 μmol and no greater than 2500 μmol per gram, and the amount of primary amino groups on the water-insoluble carrier being no greater than 450 μmol per gram.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
68.
IMMUNOSUPPRESSIVE LEUKOCYTE ADSORPTION MATERIAL AND ADSORPTION COLUMN
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Ueno Yoshiyuki
Kasuya Junichi
Arakane Toru
Matsunaga Ryo
Sekiya Yumiko
Ueda Yuji
Teramoto Kazuo
Ogasawara Kazumasa
Abstract
The purpose of the present invention is to provide an adsorption material capable of selectively adsorbing immunosuppressive leukocytes. The present disclosure provides an immunosuppressive leukocyte adsorption material containing a water-insoluble carrier to which is bonded one or more nitrogen-containing compounds selected from polyamines represented by a prescribed formula and aliphatic amines represented by a prescribed formula, the water-insoluble carrier having the form of fibers or particles, the diameter of the fibers or the particles being 15-50 μm, and the arithmetic mean roughness of the surface of the water-insoluble carrier being 0.1-3.0 μm.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
69.
Cell-holding substrate holder for preparing observation specimen, kit including same, and observation specimen preparation method
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
JAPAN VILENE COMPANY, LTD. (Japan)
Inventor
Mukaisho, Ken-Ichi
Hattori, Takanori
Iwasa, Takuya
Kawabe, Masaaki
Kumagai, Satoshi
Abstract
Provided are a cell-holding substrate holder for preparing an observation specimen, and a cell-holding substrate kit, wherein the cell-holding substrate can be easily attached and detached. Also provided is a method of preparing an observation specimen, wherein cell organelles can be satisfactorily observed using an optical microscope, while three problems of cell detachment, drying, and loss of the three-dimensional properties can be simultaneously solved. The cell-holding substrate holder comprises (1) a support plate 1 having a cell-holding substrate arrangement portion 12 having a window portion through which water can pass; and (2) a removable sandwiching plate 2, 3 which has a window portion through which water can pass, and is capable of working in conjunction with the support plate 1 to sandwich and fix a cell-holding substrate 9 in the cell-holding substrate arrangement portion 12. The cell-holding substrate kit 10 comprises the cell-holding substrate holder and a cell-holding substrate 9. In the preparation method, cells are collected with an inorganic fiber aggregate, wet-fixed as they are, stained, and mounted with a mounting medium having a refractive index equivalent to that of the inorganic fiber.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Morita, Shin-Ya
Abstract
Disclosed is a method for quantifying the phosphatidylinositol in a sample, wherein the method has the following step: (1) a step for causing the action of phospholipase D and inositol dehydrogenase on the sample. Also disclosed is a phosphatidylinositol quantification kit that contains phospholipase D and inositol dehydrogenase.
C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase
C12Q 1/28 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase involving peroxidase
71.
DIAGNOSTIC IMAGING AGENT AND EXTRACORPOREAL DIAGNOSTIC AGENT FOR INTRACTABLE NEUROLOGICAL DISEASES
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
OTSUKA PHARMACEUTICAL CO., LTD. (Japan)
Inventor
Tooyama, Ikuo
Yanagisawa, Daijiro
Taguchi, Hiroyasu
Sogabe, Takayuki
Shirai, Nobuaki
Hirao, Koichi
Abstract
Disclosed is a compound selected from among aniline derivatives represented by formula (1) and naphthalene derivatives represented by formula (2), or a salt thereof. (In the formulae, each of R1 and R2 independently represents a hydrogen atom or an alkyl group; and one of A1 and A2 represents a hydrogen atom, while the other represents a fluorine atom-substituted or unsubstituted alkoxy group or a group represented by formula (AA). In formula (AA), R3 represents a fluorine atom-substituted or unsubstituted ethylene group; R4 represents a fluorine atom-substituted or unsubstituted ethyl group; and n represents an integer of 1-10. In cases where n represents an integer of 2 or more, the R3 moieties may be the same as or different from each other.)
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Yamada, Atsushi
Tani, Tohru
Morikawa, Shigehiro
Naka, Shigeyuki
Nitta, Norihisa
Abstract
Provided are: a hanger which has excellent operability and in which the direction of a loop forming member can be changed; and a medical snare. The hanger 10 is provided with: a tubular member 11 having an inner hole 11A for penetration; and a loop forming member 12 inserted into the inner hole 11a of the tubular member 11. The loop forming member 12 has first and second pieces 13, 14, front ends of which are connected to each other, and respective base ends 13b, 14b of the first and second pieces 13 and 14 are movable in a length direction Z of the tubular member 11.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 17/221 - Calculus gripping devices in the form of loops or baskets
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Ishizeki Yasunori
Manpuku Yasuhiro
Takashina Mamoru
Yokoyama, Seiichi
Ishikawa Hideki
Samejima Tsukasa
Kinoshita Yoshihiko
Asano Takuji
Tani Tohru
Naka Shigeyuki
Shiomi Hisanori
Abstract
It is difficult for microwaves radiating from two electrodes to be efficiently radiated into tissue, and practical application thereof has thus been difficult. In addition, it has been difficult to cause microwaves to radiate uniformly from the surface of a microwave application antenna. As a result of extensive research carried out to resolve these problems, the inventors of the present invention found that by optimizing the construction and arrangement of the microwave application antenna and a microwave receiver antenna, and by installing a microwave demultiplexer, it is possible for microwaves radiated from two electrodes to be efficiently radiated into tissue.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
74.
BENDING AND EXTENDING DEVICE AND BENDING AND EXTENDING METHOD
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Yamada, Atsushi
Tani, Tohru
Naka, Shigeyuki
Morikawa, Shigehiro
Abstract
Provided is a bending and extending device that has a structure advantageous for preventing unexpected local bending due to buckling. This bending and extending device 1 comprises a guide unit 2 that is elastic and is hollow, and a movable part 3 that is inserted into the guide unit 2 so as to move freely. The movable part 3 comprises a plurality of strip-shaped flexible parts 30a, 30b that extend in the axial direction of the guide unit 2, and the distal ends of the flexible parts 30a, 30b are joined together. In this bending and extending device 1, in a case where a cross section is formed in which, by way of slide operation of the flexible parts 30a, 30b, a contact point T between the flexible part 30a and the inner face of the guide unit 2 is present on an extension line Y of a line segment connecting the centroid P of the flexible part 30b and the axial center G of the guide unit 2 and the flexible parts 30a, 30b are in contact, the centroid P of the flexible part 30b is not positioned in the area in which the contact point T is present when the cross section is divided into two areas with a prescribed straight line X, where the prescribed straight line X is a straight line that passes through the axial center G of the guide unit 2 and is orthogonal to the extension line Y.
A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewingSafety devices combined with or specially adapted for use in connection with manipulators
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani, Tohru
Abstract
The present invention addresses the problem of developing a tissue joiner and a longitudinal joiner for endoscopic surgery, capable of being used for natural orifice translumenal endoscopic surgery (NOTES) and the like. As a result of extensive research aimed at solving the abovementioned problem, the inventors conceived of a tissue joiner having two completely new structures, thereby accomplishing the present invention.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
76.
CELL-HOLDING SUBSTRATE HOLDER FOR PREPARING OBSERVATION SPECIMEN, KIT INCLUDING SAME, AND OBSERVATION SPECIMEN PREPARATION METHOD
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
JAPAN VILENE COMPANY, LTD. (Japan)
Inventor
Mukaisho Ken-Ichi
Hattori Takanori
Iwasa Takuya
Kawabe Masaaki
Kumagai Satoshi
Abstract
A cell-holding substrate holder for preparing an observation specimen is provided with which the cell-holding substrate can be easily attached and detached. Also provided are: a cell-holding substrate kit; and an observation specimen preparation method with which cell organelles can be satisfactorily observed using an optical microscope, and the three problems of cell detachment, drying, and solidity loss can be simultaneously solved. The cell-holding substrate holder includes: (1) a support plate 1 provided with a cell-holding-substrate arrangement portion 12 provided with window portions through which water can pass; and (2) removable sandwiching plates 2, 3 which are provided with window portions through which water can pass, and are capable of working in conjunction with the support plate 1 to sandwich and fix the cell-holding substrate 9 in the cell-holding-substrate arrangement portion 12. The cell-holding substrate kit 10 includes the cell-holding substrate holder and the cell-holding substrate 9. In the observation specimen preparation method, cells are captured in an inorganic fibre aggregate, wet-fixed as they lie, dyed, and encapsulated using an encapsulant having the same refractive index as the inorganic fibres.
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Miki Shinya
Adachi Megumi
Tani Toru
Naka Shigeyuki
Shimizu Tomoharu
Abstract
Provided is an energy device for surgical operations in which an operation region is used for carrying out an operation, wherein the energy device is provided with a coating layer (14) which is formed on the outer peripheral surface of a base material (11) constituting the operation region to which an energy is to be transmitted, and which is composed of a base coating film (12) formed on the base material and an outermost coating film (13) formed on the base coating film, and wherein the base coating film comprises silicon oxide or a compound comprising silicon oxide and the outermost coating film comprises a polysiloxane, a compound comprising a polysiloxane or a compound comprising a partially fluorinated polysiloxane. The coating layer has good adhesion properties, and is therefore applicable to complicated shapes. The energy device can prevent the cohesion of a biological tissue.
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
National University Corporation Shiga University Of Medical Science (Japan)
Inventor
Tani, Tohru
Naka, Shigeyuki
Akabori, Hiroya
Abstract
It is an object to provide a surgical tool for excising a hard solid organ such as cirrhotic liver or cutting the organ into a groove without causing bleeding. The inventors of the present invention have found that an organ resection tool including a brush-like structure capable of performing microwave irradiation and/or a brush-like structure capable of receiving a microwave can achieve the above-mentioned object, to thereby arrive at the present invention (organ resection tool including a brush structure capable of performing microwave irradiation). For example, an organ can be crushed or scraped away by manually abrading the organ with a brush of a solid organ resection tool including a brush structure capable of performing microwave irradiation according to the present invention. Further, the organ can be concurrently coagulated through the microwave irradiation to stop bleeding.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Naka, Shigeyuki
Tani, Tohru
Abstract
Microwave-irradiating surgical instruments for endoscopic forceps or scope-assisted surgery forceps that have long lead wires often generate heat even during microwave transmission and a water supply device for cooling is necessary. Accordingly, conventional surgical instruments that irradiated energy such as microwaves had a separate passage for passing water (a water supply device) inside the forceps or endoscope. Due to the space occupied by said water supply device, the image cable or work hole diameter could not be enlarged. Moreover, the presence of the water supply device made surgery difficult. The present invention was completed by the discovery that a microwave-irradiating instrument wherein the central conductor is hollow and forms a hollow tube and said hollow tube is used as a water supply tube, etc. solves the above problems without affecting microwave irradiation efficiency.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
National University Corporation Shiga University of Medical Science (Japan)
Inventor
Tani, Tohru
Naka, Shigeyuki
Shiomi, Hisanori
Abstract
It is an object to provide a surgical instrument capable of locally applying microwaves to a minute biological tissue. It has been found that microwaves can be transmitted to a tip of a tapered coaxial body (9) and that microwaves are radiated from the entire central conductor exposed in a major axis direction by decreasing a sectional area (preferably diameter) of a central conductor (1) and a sectional area (preferably inner diameter) of an external conductor gradually or in a step-by-step manner with a ratio between the sectional area (diameter) of the central conductor (1) and the sectional area (inner diameter) of the external conductor being set to be constant, thereby achieving the present invention.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani, Tohru
Naka, Shigeyuki
Abstract
A surgical tool is provided for resecting a solid organ such as a cirrhotic liver or creating a groove in a solid organ without causing bleeding. An organ resection tool has been discovered which is able to solve this problem. This organ resection tool has a brush-like structure able to perform microwave irradiation and/or a brush-like structure able to receive microwaves. The present invention (an organ resection tool having a brush-like structure able to perform microwave irradiation) is a product of this discovery. The brush of the solid organ resection tool with a brush-like structure able to perform microwave irradiation may be held in the hand and used to scrape away or resect an organ. At the same time, the organ can be coagulated by microwave irradiation to stop bleeding.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani, Tohru
Naka, Shigeyuki
Abstract
[Problem] Provided is a device capable of acting in place of an operation for stitching tissue stitch by stitch by threaded needle or stapler. [Solution] In a tissue suturing device having a crushing unit and a projecting unit that includes a central conductor and/or external conductor for applying microwaves, the projecting unit and the crushing unit cause the fragmented parts of the tissue to be sutured to contact or overlap each other, the contacting or overlapping parts are coagulated and/or fixed by microwaves, and suturing of the tissue to be sutured is confirmed, perfecting the present invention.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani, Tohru
Naka, Shigeyuki
Shiomi, Hisanori
Abstract
The purpose of the present invention is to provide a surgical instrument whereby microwave can be applied locally to a micro tissue of a living organism. A surgical instrument, wherein, while maintaining the ratio of the cross sectional area (preferably diameter) of a central conductor (1) to the cross sectional area (preferably inner diameter) of an external conductor at a constant level, the cross sectional area (diameter) of the central conductor and the cross sectional area (inner diameter) of the external conductor are reduced gradually or stepwise. Owing to this structure, microwave can be transmitted to the tip of a tapered coaxial body (9) and the microwave can be irradiated from the whole central conductor that is exposed along the longitudinal direction. The present invention has been completed based on these findings.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
84.
Medical treatment device for holding, coagulating, and cutting living tissue
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY (Japan)
Inventor
Tani, Tohru
Naka, Shigeyuki
Abstract
In order to reliably cut off a living tissue by using a microwave in a surgical operation without causing excessive damage to the living tissue or without bleeding, it is necessary to suppress energy attenuation until the microwave reaches electrode blades for nipping, coagulating, and cutting off a tissue. However, it is difficult to suppress the energy attenuation. The present invention relates to a medical treatment device capable of reliably cutting off a living tissue by using a microwave while sealing vasculature by coagulating the living tissue without excessively damaging the living tissue. Specifically, the present invention relates to a medical treatment device including a movable first electrode blade connected to an external conductor and a fixed second electrode blade connected directly to a central electrode. The medical treatment device has a function of holding a living tissue between the movable first electrode blade and the fixed second electrode blade, coagulating the living tissue by supplying a microwave from the fixed second electrode blade, and cutting off the living tissue by turning the movable first electrode blade. In the medical treatment device, a turning mechanism for the movable first electrode blade is arranged at a certain clearance from the central electrode.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani, Tohru
Naka, Shigeyuki
Abstract
In order to reliably cut organism's tissue in surgery by means of microwaves without bleeding and without causing excess damage to the organism's tissue, it is essential that the attenuation of the energy occurring until the energy reaches electrode blades be minimized, the electrode blades coagulating and cutting the tissue while holding the tissue. However, minimizing the attenuation of the energy has been difficult. A medical treatment device which can coagulate organism's tissue, seal a vascular channel structure, and reliably cut the organism's tissue by microwaves without causing excess damage to the organism's tissue. The medical treatment device is provided with a movable first electrode blade which is connected to an outside conductor, and also with a stationary second electrode blade which is directly connected to the center electrode. The medical treatment device is configured so that organism's tissue is held between the movable first electrode blade and the stationary second electrode blade, is coagulated by microwaves supplied from the stationary second electrode blade, and is then cut by the pivoting of the movable first electrode blade. The pivoting mechanism for the electrode blade is disposed at a position a given distance away from the center electrode.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
MICRON SHIGA, INC. (Japan)
Inventor
Tani, Tohru
Kurumi, Yoshimasa
Naka, Shigeyuki
Takashina, Mamoru
Ishikawa, Hideki
Oikawa, Teruaki
Abstract
Provided is a medical treatment device which is a medical device for eliminating the inconvenience of procedures in an actual clinic, and can ensure the visual field by introducing a bend in the vicinity of an electrode part of an outer tubular casing. The medical treatment device is a microwave medical treatment device having the following structure which includes: an electrode member which includes a first electrode and a second electrode positioned opposite the first electrode and has a grasping function, a coagulation function, and a cutting function; an operating member for driving each function of the first electrode and the second electrode; a shaft member for connecting the electrode member and the operating member; a connector capable of connecting to a microwave power supply; and a conductor rod provided in the shaft member for transmitting microwaves to the electrode member; and has the actions of holding biological tissue between the first electrode and the second electrode, supplying microwaves to the first electrode and the second electrode to coagulate the biological tissue, and cutting the biological tissue by the interactions of the first electrode and the second electrode; and the shaft member and the electrode member are connected by a bent holder.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani, Tohru
Naka, Shigeyuki
Abstract
The solution of the problem to be solved is the provision of a means for determining timing both accurately and securely at which a treatment is shifted from gripping and coagulation (hemostasis or sealing) to resection by using a multifunctional treatment tool capable of exfoliation, gripping, coagulation (hemostasis or sealing) and resection of the treated region in a bipolar microwave treatment tool. A microwave surgical device control method and a device, in which the completion of coagulation (hemostasis or sealing) of tissue is detected and a microwave oscillation output is controlled by making use of the change in the direct current electric resistance value due to the reduction in the amount of water as the temperature rise of the tissue at the time of heating and coagulation of the tissue in the treated region with microwaves.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
Inventor
Tani, Tohru
Naka, Shigeyuki
Abstract
With respect to a bipolar microwave operative device, it is intended to provide means for accurately, securely judge the timing for shift from grasp and coagulation (arrest of bleeding) to cutoff of treatment site with the use of a multifunctional operative device capable of detachment, grasp, coagulation (arrest of bleeding) and cutoff at treatment site. There is provided a method of controlling a microwave surgical device, comprising detecting the completion of tissue coagulation (arrest of bleeding) with the utilization of the phenomenon that at microwave heat coagulation of the tissue at treatment site, a drop of water content occurs inaccordance with the temperature rise of the tissue to thereby cause changing of direct current electrical resistance value and, on the basis of the detection, controlling the relevant microwave oscillation output. Further, there is provided a unit for the control method.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE (Japan)
YAMASHINA SEIKI CO., LTD. (Japan)
Inventor
Hosaka, Makoto
Tani, Tohru
Kurumi, Yoshimasa
Naka, Shigeyuki
Abstract
The invention relates to an operating tool for organism, particularly microwave endoscope forceps. The operating tool has multiple functions including a holding function, a scissors function, and a coagulation function (tissue fixation) by microwaves. The operating tool has no definite fulcrum and has both holding and scissors functions by means of a simple structure by transforming a long-diameter rod called a beam. The two blades of the scissors are insulated from each other so as to enable microwave current supply. In such a way, an operating tool having three functions, i.e., 旜a holding function”, 旜a coagulating function”, and 旜a cutting function” with one item can be developed.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves