Described herein is a method of categorizing a cancer (such as into TEL+ cancer or ALT+ cancer). The method includes performing a global analysis of telomere lengths in cancer cells of the cancer, and determining the category of the cancer based on patterns of telomere lengths. Also described herein is a method of treating cancer based on the categorizing of the cancer.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
C12Q 1/683 - Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
2.
METHOD FOR AMELIORATING AUTISM SYMPTOMS BY PHARMACOLOGICAL ACTIVATION OF THE NEUROTENSIN RECEPTOR 1 (NTSR1)
A system for training a user to perform a physical activity includes a control device that obtains movement information associated with a portion of a user's body and provides image information to a display device that displays an image associated with the portion of the user's body with a second image associated with a first target that is associated with physics information associated with simulated physical characteristics of the first target and a third image associated with a second target. The control device controls movement of the first image relative to the second image and the second image relative to the third image based on the movement information and the physics information.
The present disclosure provides methods for direct sequencing of RNA, including but not limited to any coding RNA and non-coding RNA such as tRNA, rRNA, mRNA, short or long non-coding RNA as well as any of their modified forms/versions, without the need for generation of a cDNA intermediate and/or intensive sample preparation.
The present disclosure provides methods for direct sequencing of RNA, including but not limited to any coding RNA and non-coding RNA such as tRNA, rRNA, mRNA, short or long non-coding RNA as well as any of their modified forms/versions, without the need for generation of a cDNA intermediate and/or intensive sample preparation.
The present disclosure relates generally to systems and methods for determining an order of nucleotides of an RNA molecule. The method includes receiving liquid chromatography-mass-spectrometry (LC-MS) data of an RNA sample, filtering the LC-MS data based on mass, the filtering including removing masses smaller than a predetermined size, analyzing the filtered LC-MS data, to determine a plurality of RNA sequences, and reading-out an RNA sequence after determining no remaining valid nucleotides in the remaining LC-MS data. Analyzing the filtered LC-MS data includes determining a mass difference between at least two adjacent ladder fragments, and determining whether the mass difference is equal to a canonical nucleotide, or a modified nucleotide. The LC-MS data including a mass, retention time (RT), and volume. The RNA sequence including a sequence of each identified canonical nucleotide and any identified modified nucleotides.
The present disclosure relates generally to novel methods for nucleic acid sequencing. Specifically, the invention relates to a liquid chromatography-mass-spectrometry (LC-MS) based technique for direct sequencing of RNA without cDNA. The technique allows one to simultaneously read an RNA sequence with single nucleotide resolution while determining the presence, type and location of a wide spectrum of RNA modifications.
The method involves an approach of inhibiting replication of dysfunctional cells which adopt alternative lengthening of telomeres, or “ALT.” The methodology involves inhibition of Fanconi anemia complementation group M (FANCM), and one or both of breast cancer 1 (BRCA1) and Bloom syndrome protein (BLM). These molecules are the keys to the elimination of replication stress caused by ALT. In other words, they permit the dysfunctional cells to proliferate. Inhibition of these molecules inhibits proliferation.
The invention relates to a catheter useful in recording His electrogram alternans. The catheter includes a catheter probe containing at least one row of receiving poles positioned at an edge of the catheter probe, equidistantly spaced from each other.
The present disclosure relates generally to systems and methods for determining an order of nucleotides of an RNA molecule. The method includes receiving liquid chromatography-mass-spectrometry (LC-MS) data of an RNA sample, filtering the LC-MS data based on mass, the filtering including removing masses smaller than a predetermined size, analyzing the filtered LC-MS data, to determine a plurality of RNA sequences, and reading-out an RNA sequence after determining no remaining valid nucleotides in the remaining LC-MS data. Analyzing the filtered LC-MS data includes determining a mass difference between at least two adjacent ladder fragments, and determining whether the mass difference is equal to a canonical nucleotide, or a modified nucleotide. The LC-MS data including a mass, retention time (RT), and volume. The RNA sequence including a sequence of each identified canonical nucleotide and any identified modified nucleotides.
C12Q 1/6872 - Methods for sequencing involving mass spectrometry
G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
The present disclosure relates generally to novel methods for nucleic acid sequencing. Specifically, the invention relates to a liquid chromatography-mass-spectrometry (LC-MS) based technique for direct sequencing of RNA without cDNA. The technique allows one to simultaneously read an RNA sequence with single nucleotide resolution while determining the presence, type and location of a wide spectrum of RNA modifications.
A system is disclosed for use in modulating gastric activity. By appropriate deployment of the components (1a-1d, 2a-2f, 3) of the system, one can monitor and modulate slow waves in the gastrointestinal system of a subject.
The method involves an approach of inhibiting replication of dysfunctional cells which adopt alternative lengthening of telomeres, or "ALT." The methodology involves inhibition of Fanconi anemia complementation group M (FANCM), and one or both of breast cancer 1 (BRCA1) and Bloom syndrome protein (BLM). These molecules are the keys to the elimination of replication stress caused by ALT. In other words, they permit the dysfunctional cells to proliferate. Inhibition of these molecules inhibits proliferation.
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
A motorized walker is provided that can enable users to walk without being slowed by the walker and without needing to exert themselves to push the walker forward. The motorized walker provides additional haptic speed cues to inform the user's posture and locomotion control to prevent falling.
B62B 5/04 - Braking mechanismsLocking devices against movement
A61H 3/04 - Wheeled walking aids for patients or disabled persons
B60L 3/00 - Electric devices on electrically-propelled vehicles for safety purposesMonitoring operating variables, e.g. speed, deceleration or energy consumption
B60L 15/20 - Methods, circuits or devices for controlling the propulsion of electrically-propelled vehicles, e.g. their traction-motor speed, to achieve a desired performanceAdaptation of control equipment on electrically-propelled vehicles for remote actuation from a stationary place, from alternative parts of the vehicle or from alternative vehicles of the same vehicle train for control of the vehicle or its driving motor to achieve a desired performance, e.g. speed, torque, programmed variation of speed
B60L 15/30 - Methods, circuits or devices for controlling the propulsion of electrically-propelled vehicles, e.g. their traction-motor speed, to achieve a desired performanceAdaptation of control equipment on electrically-propelled vehicles for remote actuation from a stationary place, from alternative parts of the vehicle or from alternative vehicles of the same vehicle train for control of the vehicle or its driving motor to achieve a desired performance, e.g. speed, torque, programmed variation of speed with means to change-over to human control
B62D 51/04 - Motor vehicles characterised by the driver not being seated the driver walking
G01S 15/93 - Sonar systems specially adapted for specific applications for anti-collision purposes
G01S 17/93 - Lidar systems, specially adapted for specific applications for anti-collision purposes
A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
16.
Catheter for use in recording his electrogram alternans and application to various conditions
The invention relates to a catheter useful in recording His electrogram alternans. The catheter includes a catheter probe containing at least one row of receiving poles positioned at an edge of the catheter probe, equidistantly spaced from each other.
The invention relates to a catheter useful in recording His electrogram alternans. The catheter includes a catheter probe containing at least one row of receiving poles positioned at an edge of the catheter probe, equidistantly spaced from each other. An apparatus useful in receiving an electrical signal from cardiac tissue, said apparatus comprising a catheter probe at one end and a flexible elongate member at the other end, wherein said catheter probe comprises a plurality of receiving poles positioned in a row at a first edge of said probe, said poles positioned equidistant from each other, wherein said catheter probe is from about 6 cm to about 10 cm in length, and from about 3 mm to about 5 mm in width or diameter, and said elongate member is capable of moving through a human blood vessel.
A motorized walker is provided that can enable users to walk without being slowed by the walker and without needing to exert themselves to push the walker forward. The motorized walker provides additional haptic speed cues to inform the user's posture and locomotion control to prevent falling.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Promoting public awareness of the continuing need for, importance and benefits of research, education and training in the fields of science, technology, engineering, arts and mathematics; promoting public awareness of the continuing need for, importance and benefits of research, education and training in the fields of science, technology, engineering, arts and mathematics via land vehicles managed by individuals who travel the country and provide said services at various locations Educational services, namely, providing educational speakers, educational programs, educational presentations, demonstrations, live exhibitions and hands-on exercises in the fields of science, technology, engineering, arts and mathematics; educational services, namely, providing educational speakers, educational programs, educational presentations, demonstrations, live exhibitions and hands-on exercises in the fields of science, technology, engineering, arts and mathematics via land vehicles managed by individuals who travel the country and provide said services at various locations
20.
Interface bracket for attachment of recyclable vessels and roofing material made using same
The invention relates to an apparatus, e.g., a bracket, configured for reception of vessels, such as plastic bottles which have been cut in a way which makes them useful upon assembly, as roofing construction elements. The roofing elements, the roofing structures which result and kits for manufacturing these structures, are all features of the invention.
E04D 1/34 - Fastenings for attaching roof-covering elements to the supporting elements
E04D 1/24 - Roofing elements with cavities, e.g. hollow tiles
B65D 71/50 - Bundles of articles held together by packaging elements for convenience of storage or transport, e.g. portable segregating carrier for plural receptacles such as beer cans or pop bottlesBales of material comprising a plurality of articles held together only partially by packaging elements formed otherwise than by folding a blank
B65D 81/36 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents adapted to be used for non-packaging purposes after removal of contents
21.
INTERFACE BRACKET FOR ATTACHMENT OF RECYCLABLE VESSELS AND ROOFING MATERIAL MADE USING SAME
The invention relates to an apparatus, e.g., a bracket, configured for reception of vessels, such as plastic bottles which have been cut in a way which makes them useful upon assembly, as roofing construction elements. The roofing elements, the roofing structures which result and kits for manufacturing these structures, are all features of the invention.
The invention relates to the discovery that resveratrol, and substituted forms of resveratrol, are effective in alleviating benign prostate hyperplasia. Formulations containing the resveratrol or resveratrol derivative, lack omega-3 fatty acids, and also contain no other compounds which activate SIRTl and PGCα.
A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
16 - Paper, cardboard and goods made from these materials
20 - Furniture and decorative products
24 - Textiles and textile goods
25 - Clothing; footwear; headgear
41 - Education, entertainment, sporting and cultural services
Goods & Services
Printed matter, namely, [ calendars, ] diaries academic catalogs, [ laboratory books, lecture notes and outlines, ] paper forms * ; * [ , course books and text books in the field of higher education and training, academic lists in the fields of allied health and life sciences, architecture and design, arts, sciences and communications, education and professional services, engineering and technology, extended education, and management; ] academic class schedules, [ printed certificates, printed certificates in the form of academic diplomas, posters, ] stationery, folders, paper or file folders [ , three-ring binders, paper and plastic shopping bags ] [ Plastic and wood file or book crates ] Cloth flags [ , cloth banners and table cloths not of paper ] Tee shirts, [ sweat shirts, sweat pants, ] warm-up jackets [ , pants, athletic uniforms ] Educational services in the nature of courses of instruction at the college and graduate level; [ providing continuing education courses for credit or non-credit in the fields of information technology, English language instruction, precollege preparation, architecture, art and design, business management, computer graphics, computer technology, corporate training, culinary arts, engineering, financial planning and interior decoration; ] organizing, arranging and conducting athletic [ and cultural ] activities
41 - Education, entertainment, sporting and cultural services
Goods & Services
[ EDUCATIONAL SERVICES, NAMELY, -PROVIDING COURSES OF INSTRUCTION AT THE COLLEGE AND GRADUATE LEVEL; PROVIDING COURSES AND PROGRAMS OF CONTINUING EDUCATION FOR CREDIT AND/OR NONCREDIT;] PROVIDING EDUCATIONAL AND ATHLETIC COURSES AND PROGRAMS FOR MINORS; ORGANIZING, ARRANGING AND CONDUCTING ATHLETIC, CULTURAL AND SOCIAL ACTIVITIES
41 - Education, entertainment, sporting and cultural services
Goods & Services
EDUCATIONAL SERVICES, NAMELY, - PROVIDING COURSES OF INSTRUCTION AT THE COLLEGE AND GRADUATE LEVEL; PROVIDING COURSES AND PROGRAMS OF CONTINUING EDUCATION FOR CREDIT AND/OR NONCREDIT; PROVIDING EDUCATIONAL AND ATHLETIC COURSES AND PROGRAMS FOR MINORS; ORGANIZING, ARRANGING AND CONDUCTING ATHLETIC, CULTURAL AND SOCIAL ACTIVITIES
