NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Yunoki, Shunji
Kondo, Eiji
Hiraoka, Yosuke
Mandai, Yoshinobu
Kishimoto, Masanori
Abstract
This collagen yarn contains collagen nanofibrils, and has a diameter of 10-50 μm and a total length of 2 × 105times or more greater than the diameter, wherein the collagen nanofibrils exhibit high alignment properties along the longitudinal direction of the collagen yarn, the high alignment properties are indicated by a fact that the refractive index difference determined by a birefringence measurement performed on a hydrated collagen yarn is 4.3 × 10-4 or more, and the hydrated collagen yarn is obtained by immersing the collagen yarn in a neutral phosphate buffer solution.
The purpose of the present invention is to provide a food or beverage in which turbidity caused by the reaction between polyphenol and a collagen peptide is reduced and which has a good flavor. Provided is a food or beverage containing polyphenol and a collagen peptide, wherein the food or beverage further contains gelatin, and the isoelectric point (X) of the gelatin and the pH (Y) of the food or beverage satisfies the relationship represented by formula 1.
C12G 3/04 - Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
3.
LEAKAGE INHIBITING AGENT FOR LOCAL INJECTION PREPARATION, LOCAL INJECTION PREPARATION INCLUDING THE SAME, AND METHOD FOR PRODUCING LOCAL INJECTION PREPARATION
A leakage inhibiting agent includes a gelatin hydrolysate having a weight average molecular weight of 5000 or lees, wherein a degree of viscosity at 25° C. of a first solution obtained by dissolving the gelatin hydrolysate in phosphate buffered saline and adjusting the concentration of the gelatin hydrolysate to 40% by mans is 20 mPa·s or less.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
31 - Agricultural products; live animals
32 - Beers; non-alcoholic beverages
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
43 - Food and drink services, temporary accommodation
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Gelatin for industrial purposes for use in the manufacture
of food; gelatin for industrial purposes for use in the
manufacture of nutritional supplements; gelatin for
industrial purposes for use in the manufacture of capsules;
peptide for industrial purposes for use in the manufacture
of food; peptide for industrial purposes for use in the
manufacture of nutritional supplements; gelling agents for
industrial purposes for use in the manufacture of food;
culture medium for culturing biological cells; reagents for
science, other than for medical or veterinary purposes;
industrial chemicals; gelatin for photographic purposes;
gelatin for photographic film; gelatin for photographic
paper; gelatin for photosensitive material; gelatin for
photographic emulsions; gelatin used as excipient agents in
the manufacture of pharmaceuticals; hydrolyzed gelatin used
as excipient agents in the manufacture of pharmaceuticals;
powdered hydrolyzed gelatin used as excipient agents in the
manufacture of pharmaceuticals. Cosmetics; cosmetics for skin care; make-up and cosmetics. Protein dietary supplements in a form of powder, granule,
tablet, grain, paste, jelly, gel or capsule; dietary
supplements for humans; dietary supplements for animals;
collagen for medical purposes; collagen peptide for medical
purposes; gelatin for medical purposes; media for microbial
cultures for medical use; pharmaceuticals; gelatin drug
delivery agents for pharmaceutical excipients; hydrolyzed
gelatin drug delivery agents for pharmaceutical excipients;
powdered hydrolyzed gelatin drug delivery agents for
pharmaceutical excipients; processed products of gelatin or
collagen for medical use, namely, adhesive plasters,
bandages, dressings and surgical glues. Artificial skin for surgical purposes; absorbable sutures;
apparatus for the regeneration of stem cells for medical
purposes; processed products of gelatin or collagen for
medical use, namely, surgical implants made of artificial
materials for skin regeneration, artificial skin and
bioabsorbable sutures; medical apparatus and instruments. Gelatin for food; collagen peptide being gelatin for food. Instant jelly mixes. Animal foodstuffs; animal forage. Powders for effervescing beverages; carbonated drink mixes;
refreshing beverages; carbonated drinks; soft drinks. Advertising through moving image; internet advertising
services; advertising of business websites; commercial
intermediation services for mail-order sales of products
through the internet. Providing videos from the internet, not downloadable. Providing information in the nature of recipes for drinks
and meals; providing information concerning cooking recipes. Providing information about beauty; providing health
information; providing medical information.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
31 - Agricultural products; live animals
32 - Beers; non-alcoholic beverages
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
43 - Food and drink services, temporary accommodation
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Gelatin for industrial purposes for use in the manufacture
of food; gelatin for industrial purposes for use in the
manufacture of nutritional supplements; gelatin for
industrial purposes for use in the manufacture of capsules;
peptide for industrial purposes for use in the manufacture
of food; peptide for industrial purposes for use in the
manufacture of nutritional supplements; gelling agents for
industrial purposes for use in the manufacture of food;
culture medium for culturing biological cells; reagents for
science, other than for medical or veterinary purposes;
industrial chemicals; gelatin for photographic purposes;
gelatin for photographic film; gelatin for photographic
paper; gelatin for photosensitive material; gelatin for
photographic emulsions; gelatin used as excipient agents in
the manufacture of pharmaceuticals; hydrolyzed gelatin used
as excipient agents in the manufacture of pharmaceuticals;
powdered hydrolyzed gelatin used as excipient agents in the
manufacture of pharmaceuticals. Cosmetics; cosmetics for skin care; make-up and cosmetics. Protein dietary supplements in a form of powder, granule,
tablet, grain, paste, jelly, gel or capsule; dietary
supplements for humans; dietary supplements for animals;
collagen for medical purposes; collagen peptide for medical
purposes; gelatin for medical purposes; media for microbial
cultures for medical use; pharmaceuticals; gelatin drug
delivery agents for pharmaceutical excipients; hydrolyzed
gelatin drug delivery agents for pharmaceutical excipients;
powdered hydrolyzed gelatin drug delivery agents for
pharmaceutical excipients; processed products of gelatin or
collagen for medical use, namely, adhesive plasters,
bandages, dressings and surgical glues. Artificial skin for surgical purposes; absorbable sutures;
apparatus for the regeneration of stem cells for medical
purposes; processed products of gelatin or collagen for
medical use, namely, surgical implants made of artificial
materials for skin regeneration, artificial skin and
bioabsorbable sutures; medical apparatus and instruments. Gelatin for food; collagen peptide being gelatin for food. Instant jelly mixes. Animal foodstuffs; animal forage. Powders for effervescing beverages; carbonated drink mixes;
refreshing beverages; carbonated drinks; soft drinks. Advertising through moving image; internet advertising
services; advertising of business websites; commercial
intermediation services for mail-order sales of products
through the internet. Providing videos from the internet, not downloadable. Providing information in the nature of recipes for drinks
and meals; providing information concerning cooking recipes. Providing information about beauty; providing health
information; providing medical information.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
(1) Gelatin for industrial purposes for use in the manufacture of food; gelatin for industrial purposes for use in the manufacture of nutritional supplements; gelatin for industrial purposes for use in the manufacture of capsules; peptide for industrial purposes for use in the manufacture of food; peptide for industrial purposes for use in the manufacture of nutritional supplements; gelling agents for industrial purposes for use in the manufacture of food; culture medium for culturing biological cells; reagents for science, other than for medical or veterinary purposes; industrial chemicals; gelatin for photographic purposes; gelatin for photographic film; gelatin for photographic paper; gelatin for photosensitive material; gelatin for photographic emulsions; gelatin used as excipient agents in the manufacture of pharmaceuticals; hydrolyzed gelatin used as excipient agents in the manufacture of pharmaceuticals; powdered hydrolyzed gelatin used as excipient agents in the manufacture of pharmaceuticals.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Gelatin for industrial purposes for use in the manufacture of food; gelatin for industrial purposes for use in the manufacture of nutritional supplements; gelatin for industrial purposes for use in the manufacture of capsules; collagen peptide for industrial purposes for use in the manufacture of food; collagen peptide for industrial purposes for use in the manufacture of nutritional supplements; chemical additives, namely, gelling agents for industrial purposes for use in the manufacture of food; culture media for cultivating microbial cells for scientific and research purposes other than for medical or veterinary purposes; reagents for scientific and research use, other than for medical or veterinary purposes; industrial chemicals; gelatin for photographic purposes; gelatin for photographic film; gelatin for photographic paper; gelatin for photosensitive material; gelatin for photographic emulsions; gelatin used as excipient agents in the manufacture of pharmaceuticals; hydrolyzed gelatin used as excipient agents in the manufacture of pharmaceuticals; powdered hydrolyzed gelatin used as excipient agents in the manufacture of pharmaceuticals.
8.
VIRUS STABILIZER, GELATIN HYDROLYSATE FOR VIRUS STABILIZER, AND VIRUSCONTAINING COMPOSITION
The virus stabilizer is a virus stabilizer comprising a gelatin hydrolysate and an aqueous medium, wherein the virus stabilizer contains the gelatin hydrolysate at not less than 1 mass % and not more than 20 mass %, the gelatin hydrolysate has a weight average molecular weight of not more than 10000, and the gelatin hydrolysate has an isoelectric point pH of not less than 4.0 and not more than 7.0.
This composition for stabilizing acidic milk beverages contains at least a gelatin and sulfate ions, in which the gelatin is an acid-treated gelatin, and a first solution prepared by adding the composition for stabilizing acidic milk beverages to water in such a manner that the concentration of the gelatin becomes 5% by mass and then leaving the resultant solution to stand at 5±1°C for 18 hours contains the sulfate ions in an amount of 5000 ppm to 30000 ppm inclusive.
LEAKAGE INHIBITING AGENT FOR LOCAL INJECTION PREPARATION, LOCAL INJECTION PREPARATION INCLUDING THE SAME, AND METHOD FOR PRODUCING LOCAL INJECTION PREPARATION
A leakage inhibiting agent includes a gelatin hydrolysate having a weight average molecular weight of 5000 or less, wherein a degree of viscosity at 25?C of a first solution obtained by dissolving the gelatin hydrolysate in phosphate buffered saline and adjusting the concentration of the gelatin hydrolysate to 40% by mass is 20 mPa·s or less.
A biological function regulating agent comprises a fermented collagen peptide, and the fermented collagen peptide has at least one action selected from the group consisting of an epidermal metabolism promoting action, a fat accumulation inhibiting action, a fat decomposition promoting action and an action of regulating the amount of adipocytokine in a biological body.
A leakage inhibiting agent comprising a gelatin hydrolysate having a weight average molecular weight of 5000 or less, wherein the viscosity, at 25°C, of a first solution, obtained by dissolving the gelatin hydrolysate in phosphate buffered saline such that the concentration of the gelatin hydrolysate becomes 40 mass%, is 20 mPa·s or less.
A peptide composition comprises a collagen peptide, and at least three first compounds selected from the group consisting of isovaleric aldehyde, 1-octen-3-ol, phenylacetaldehyde and methional.
A brain function regulating agent contains a peptide comprising an amino acid sequence represented by Glu-Hyp-Gly, a salt thereof, or a chemically modified product thereof.
A hair growing agent comprises one or more amino acids or peptides selected from the group consisting of Hyp, Pro-Hyp, Hyp-Gly, Gly-Pro, Leu-Hyp, Phe-Hyp, Pro-Ala, Pro-Gly, Pro-Pro, Glu-Hyp, Gly-Pro-Hyp, Ala-Hyp-Gly, Glu-Hyp-Gly, Pro-Ala-Gly and Ser-Hyp-Gly, a salt thereof, or a chemically modified product thereof.
A virus stabilizer comprising a gelatin hydrolysate and an aqueous medium, in which the gelatin hydrolysate is contained in an amount of 1 to 20% by mass inclusive in the virus stabilizer, the gelatin hydrolysate has a weight average molecular weight of 10000 or less, and the gelatin hydrolysate has a pH value at an isoelectric point of 4.0 to 7.0 inclusive.
The virus stabilizer is a virus stabilizer comprising a gelatin hydrolysate and an aqueous medium, wherein the virus stabilizer contains the gelatin hydrolysate at not less than 1 mass% and not more than 20 mass%, the gelatin hydrolysate has a weight average molecular weight of not more than 10000, and the gelatin hydrolysate has an isoelectric point pH of not less than 4.0 and not more than 7.0.
An aging progression suppressing agent comprises both or one of the peptides of Gly-Pro and Glu-Hyp-Gly, a salt thereof, or a chemically modified product thereof.
A biological function regulating agent comprises a fermented collagen peptide, and the fermented collagen peptide has at least one action selected from the group consisting of an epidermal metabolism promoting action, a fat accumulation inhibiting action, a fat decomposition promoting action and an action of regulating the amount of adipocytokine in a biological body.
This peptide composition contains: a collagen peptide; and at least three types of first compounds selected from the group consisting of isovaleraldehyde, 1-octen-3-ol, phenyl acetaldehyde, and methional.
A peptide composition comprises a collagen peptide, and at least three first compounds selected from the group consisting of isovaleric aldehyde, 1-octen-3-ol, phenylacetaldehyde and methional.
A biological function regulating agent comprises a fermented collagen peptide, in which the fermented collagen peptide has at least one activity selected from the group consisting of an epidermal metabolism promoting activity, a fat accumulation inhibiting activity, a fat decomposition promoting activity and an activity to control the amount of an adipocytokine in a living body.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Collagen peptide ingredients for use in dietary supplement
applications (term considered too vague by the International
Bureau - Rule 13 (2) (b) of the Regulations).
24.
HAIR GROWING AGENT AND FOOD OR BEVERAGE PRODUCT COMPRISING SAME
This hair growing agent contains at least one amino acid or peptide selected from the group consisting of Hyp, Pro-Hyp, Hyp-Gly, Gly-Pro, Leu-Hyp, Phe-Hyp, Pro-Ala, Pro-Gly, Pro-Pro, Glu-Hyp, Gly-Pro-Hyp, Ala-Hyp-Gly, Glu-Hyp-Gly, Pro-Ala-Gly, and Ser-Hyp-Gly, or a salt thereof, or a chemically modified product thereof.
A retardant for the progression of aging that comprises a peptide Gly-Pro and/or a peptide Glu-Hyp-Gly, a salt thereof or a chemically modified product of the same.
C07K 5/062 - Dipeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/093 - Tripeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
26.
HAIR GROWING AGENT AND FOOD AND DRINK CONTAINING SAME
This hair growing agent contains at least one amino acid or peptide selected from the group consisting of Hyp, Pro-Hyp, Hyp-Gly, Gly-Pro, Leu-Hyp, Phe-Hyp, Pro-Ala, Pro-Gly, Pro-Pro, Glu-Hyp, Gly-Pro-Hyp, Ala-Hyp-Gly, Glu-Hyp-Gly, Pro-Ala-Gly, and Ser-Hyp-Gly, or a salt thereof, or a chemically modified product thereof.
A retardant for the progression of aging that comprises a peptide Gly-Pro and/or a peptide Glu-Hyp-Gly, a salt thereof or a chemically modified product of the same.
C07K 5/062 - Dipeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/093 - Tripeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
collagen peptide for use as an ingredient in the manufacture of dietary supplements collagen peptide sold as a component ingredient of dietary supplements
30.
BRAIN FUNCTION REGULATING AGENT, AND FOOD OR BEVERAGE PRODUCT CONTAINING SAME
A brain function regulator that comprises a peptide containing an amino acid sequence represented by Glu-Hyp-Gly, a salt thereof or a chemical modification of the same.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07K 5/093 - Tripeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
31.
BRAIN FUNCTION REGULATOR, AND FOOD OR BEVERAGE CONTAINING SAME
A brain function regulator that comprises a peptide containing an amino acid sequence represented by Glu-Hyp-Gly, a salt thereof or a chemical modification of the same.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 43/00 - Drugs for specific purposes, not provided for in groups
C07K 5/093 - Tripeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
Goods & Services
Gelatin for use in the manufacture of food products; gelatin
as additives for use in the manufacture of food products;
gelatin for use in the manufacture of food supplements;
gelatin as additives for use in the manufacture of food
supplements; gelatin for use in the manufacture of capsules;
gelatin for use in the manufacture of cosmetics; gelatin as
additives for use in the manufacture of cosmetics; chemicals
for use in industry and science; chemical additives for use
in manufacture; proteins for use in manufacture; plant
growth regulating preparations; fertilizers; higher fatty
acids; chemical compositions for developing and printing
photographs; reagent paper, not for medical purposes;
artificial sweeteners; flour and starch for industrial
purposes; plastics as raw materials; collagen-peptide for
the food industry; proteins for the food industry. Dietary supplements in soft capsule form; dietary
supplements in capsule form; dietary supplements for humans;
nutritional supplement drinks; dietary supplements with a
cosmetic effect; collagen-based medicated food supplements;
gelatin capsules for medicines; gelatin capsules, empty, for
pharmaceuticals; empty capsules for pharmaceutical purposes;
capsules for veterinary pharmaceutical preparations; gelatin
for medical purposes; collagen for medical purposes; oiled
paper for medical purposes; adhesive tapes for medical
purposes; drug delivery agents in the form of edible wafers
for wrapping powdered pharmaceuticals; pharmaceutical
preparations; reagent paper for medical purposes; lacteal
flour for babies; powdered milk for babies; dietetic
beverages adapted for medical purposes; dietetic foods
adapted for medical purposes; beverages for babies; food for
babies; dietary supplements for animals; protein supplements
for humans. Gelatin for food; unflavored and unsweetened gelatin;
instant jelly mixes; edible oils and fats; milk products;
frozen vegetables; frozen fruits; processed meat products;
processed seafood products; processed vegetables and fruits;
soya milk; pre-cooked curry stew, stew and soup mixes.
33.
COLLAGEN CASING, CASING FOOD COMPRISING SAME, METHOD FOR PRODUCING COLLAGEN CASING, METHOD FOR PRODUCING CASING FOOD, COLLAGEN GEL FOR ENCLOSING FOOD, FOOD ENCLOSED IN GEL COMPRISING SAME, METHOD FOR PRODUCING COLLAGEN GEL FOR ENCLOSING FOOD AND METHOD FOR PRODUCING FOOD ENCLOSED IN GEL
A collagen casing comprising cellulose particles, wherein: the cellulose particles have an average particle size of 10-60 μm inclusive; and, when a dispersion of the cellulose particles, which is prepared by adding 0.5 g of a powder of the cellulose particles to 100 mL of water followed by stirring, is allowed to stand for 10 seconds and then the cellulose particles are collected from the supernatant, the collection yield of the cellulose particles is 65% or higher.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Gelatin for use in the manufacture of food products; gelatin as additives for use in the manufacture of food products; gelatin for use in the manufacture of food supplements; gelatin as additives for use in the manufacture of food supplements; gelatin for use in the manufacture of capsules; gelatin for use in the manufacture of cosmetics; gelatin as additives for use in the manufacture of cosmetics; proteins for use in the manufacture of food and beverages; proteins for use in the manufacture of food supplements; plant growth regulating preparations; fertilizers; higher fatty acids; chemical compositions for developing and printing photographs; artificial sweeteners; collagen-peptide for the food industry; unprocessed gelatin protein for use as a food additive for both human and animal consumption; prepared and processed gelatin protein for use as a food additive for both human and animal consumption
(2) Nutritional supplements to promote general health and well-being in capsule form; nutritional supplements for humans to promote general health and well-being in tablet form; nutritional supplement drinks to promote general health and well-being; dietary supplements to promote skin health in capsule form; dietary supplements to promote skin health in tablet form; gelatin in raw form for use in the production of medicinal capsule shells and medicinal tablets; gelatin capsules sold empty for medicine; gelatin capsules, empty, for pharmaceuticals; empty capsules for pharmaceutical purposes; capsules sold empty for veterinary pharmaceutical preparations; adhesive tapes for medical purposes; drug delivery agents in the form of edible wafers for wrapping powdered pharmaceuticals; reagent paper for medical purposes; lacteal flour for babies; powdered milk for babies; beverages for babies; food for babies
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Gelatin for use in the manufacture of food products; gelatin as additives for use in the manufacture of food products; gelatin for use in the manufacture of food supplements; gelatin as additives for use in the manufacture of food supplements; gelatin for use in the manufacture of capsules; gelatin for use in the manufacture of cosmetics; gelatin as additives for use in the manufacture of cosmetics; chemicals for use in industry and science; chemical additives for use in manufacture of food; chemical additives for use in manufacture of cosmetics; chemical additives for use in manufacture of pharmaceuticals; proteins for use in manufacture; plant growth regulating preparations; fertilizers; higher fatty acids for industrial purposes; chemical compositions for developing and printing photographs; reagent paper, not for medical purposes; artificial sweeteners; flour and starch for industrial purposes; unprocessed plastics as raw materials; collagen-peptide for the food industry; proteins for the food industry Dietary supplements in soft capsule form; dietary supplements in capsule form; dietary supplements for humans; nutritional supplement drinks; dietary supplements with a cosmetic effect; collagen-based medicated food supplements; gelatin capsules for medicines, namely, capsules sold empty for pharmaceuticals; gelatin capsules, sold empty, for pharmaceuticals; empty capsules for pharmaceutical purposes; capsules sold empty for veterinary pharmaceutical preparations; gelatin for medical purposes, namely, as hemostatics; collagen for medical purposes; oiled paper for medical purposes; adhesive tapes for medical purposes; drug delivery agents in the form of edible wafers for wrapping powdered pharmaceuticals; pharmaceutical preparations, namely, antidepressants; pharmaceutical preparations for treating allergies; reagent paper for medical purposes; lacteal flour for babies; powdered milk for babies; dietetic beverages adapted for medical purposes; dietetic foods adapted for medical purposes; beverages for babies being baby food; food for babies; dietary supplements for animals; protein supplements for humans
This hypertrophic scar inhibiting composition contains at least one of polypeptides comprising an amino acid sequence having the dipeptide sequence represented by Pro-Hyp or Hyp-Gly, chemically modified products thereof and pharmaceutically acceptable salts thereof.
29 - Meat, dairy products, prepared or preserved foods
Goods & Services
(1) Unflavored and unsweetened gelatins for use in food substances; gelatin, namely, protein being foodstuffs for human consumption; gelatin, namely, protein for use as a food additive
29 - Meat, dairy products, prepared or preserved foods
Goods & Services
Unflavored and unsweetened gelatins for use in food substances; unflavored and unsweetened gelatin, namely, protein being foodstuffs for human consumption; unflavored and unsweetened gelatin, namely, protein for use as a food additive
41.
Gelatin, chemically modified product thereof, aqueous composition and medical laminate containing same, production method for medical laminate, and cell sheet isolation method
TOKYO METROPOLITAN INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (Japan)
NITTA GELATIN INC. (Japan)
Inventor
Ohyabu, Yoshimi
Yunoki, Shunji
Hatayama, Hirosuke
Ida, Masataka
Hiraoka, Yosuke
Abstract
A gelatin or a chemically modified product thereof contains 10 to 50% by mass of a high-molecular weight component, and a low-molecular weight component in such an amount that a value obtained by subtracting a low-molecular weight component content from a high-molecular weight component content is greater than or equal to 0% by mass.
A61L 15/40 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Biological tissue cultures, other than for medical or
veterinary purposes; biological preparations for use in cell
cultures, other than for medical or veterinary use; cell
culture reagents for scientific or research purposes; cell
culture reagents for laboratory use; diagnostic reagents for
scientific or research use; reagents for research purposes. Gelatin for medical purposes; collagen for medical purposes;
collagen peptide for medical purposes; biological tissue
cultures for medical purposes; biological preparations for
medical purposes; pharmaceuticals.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Biological preparation for use in cell cultures other than for medical or veterinary use, namely, for cell transplantation and cell transportation, cell culture biological preparation used in scientific research; biological tissue cultures for scientific research use; cell culture reagents for laboratory use; cell culture reagents for scientific or research purposes; chemical reagents for scientific or research purposes; diagnostic preparations for medical-scientific research use, diagnostic preparations for in vitro use in biochemistry, clinical chemistry and microbiology, diagnostic reagents for medical-scientific research use; diagnostic reagents for scientific or research use; reagents for research purposes; excipients, namely anti-adherents, binders, stabilizers, thickeners, coatings, disintegrants, glidants, lubricants, preservatives and sorbents for use in the manufacture of pharmaceutical preparations
(2) Biological preparations for medical purposes, namely, carriers for drug delivery systems, stabilizers of viruses, cell culture mediums for growing stem cells, cell transplantation and transportation; biological tissue cultures for medical purposes; collagen for medical purposes; collagen peptide for medical purposes; clinical diagnostic reagents, diagnostic biomarker reagents for medical purposes, diagnostic preparations for clinical laboratory use, diagnostic preparations for medical laboratory use, diagnostic preparations for medical purposes for detecting genetic predispositions, diagnostic reagents for clinical laboratory use, diagnostic reagents for medical diagnostic use, diagnostic reagents for medical laboratory use, diagnostic reagents for veterinary purposes, in vitro diagnostic preparations for medical purposes; gelatine for medical purposes
44.
DIFFERENTIATION INDUCER AND METHOD FOR INDUCING DIFFERENTIATION, AND DECOMPOSED BONE TISSUE PRODUCTION METHOD USED THEREFOR
Provided are a differentiation inducer and a method for inducing differentiation that can be used in bone tissue regeneration by using a decomposed bone tissue that is produced by causing a cysteine protease and bone tissue to react in a liquid solution of a defined pH.
A61L 27/00 - Materials for prostheses or for coating prostheses
45.
GELATIN, CHEMICALLY MODIFIED PRODUCT THEREOF, AQUEOUS COMPOSITION AND MEDICAL LAMINATE CONTAINING SAME, PRODUCTION METHOD FOR MEDICAL LAMINATE, AND CELL SHEET ISOLATION METHOD
TOKYO METROPOLITAN INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (Japan)
NITTA GELATIN INC. (Japan)
Inventor
Ohyabu, Yoshimi
Yunoki, Shunji
Hatayama, Hirosuke
Ida, Masataka
Hiraoka, Yosuke
Abstract
A gelatin or chemically modified product thereof having a high-molecular weight component content of 10%-50% by mass and having a value, being the low-molecular weight component content deducted from the high-molecular weight component content, of at least 0% by mass.
A peptide selected from the group consisting of Ala-Hyp-Gly, Hyp-Gly-Pro, Leu-Hyp, Glu-Hyp, Gly-Pro-Hyp, Pro-Ala, Hyp-Gly and Pro-Hyp, or a pharmaceutically acceptable salt thereof has a myoblast differentiation promoting effect superior to conventional arts.
C07K 5/062 - Dipeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/072 - Dipeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 5/083 - Tripeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/078 - Dipeptides the first amino acid being heterocyclic, e.g. Pro, His, Trp
C07K 5/097 - Tripeptides the first amino acid being heterocyclic, e.g. Pro, His, Trp, e.g. thyroliberin, melanostatin
An object is to provide an acid milk beverage, which shows no precipitation or aggregation and reduced whey separation, and which has a refreshing texture, even in cases where the acid milk beverage has a low solids-not-fat concentration. An acid milk beverage characterized by containing an acid milk beverage base and a pectin having an intrinsic viscosity of 5.9 to 8.5, a degree of esterification of 74 to 80, and a calcium reactivity of 230 or less is provided.
A peptide that is selected from the group consisting of Hyp-Gly, Pro-Ala-Gly, Gly-Pro, Glu-Hyp-Gly, (Pro-Hyp-Gly)5, (Pro-Hyp-Gly)2, Pro-Hyp-Gly, Glu-Hyp, Ala-Hyp-Gly, Ser-Hyp-Gly and Phe-Hyp or a pharmaceutically acceptable salt thereof is useful as a whitening promoting agent or atopic dermatitis improving agent.
A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
A61K 8/65 - CollagenGelatinKeratinDerivatives or degradation products thereof
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
Provided is a human corneal endothelial cell sheet characterized by having a curvature suitable for human corneal endothelial surface, in particular, the human corneal endothelial cell sheet that is supported by a cell support having a curvature suitable for human corneal endothelial surface. Also provided is a method for producing a human corneal endothelial cell sheet having a curvature suitable for human corneal endothelial surface, said method comprising: (1) a step for gelling an aqueous gelatin solution having been poured into a mold that has a curvature suitable for human corneal endothelial surface; (2)a step for drying the gelled gelatin obtained in step (1) to form sheet-type gelatin; (3) a step for thermally crosslinking the sheet-type gelatin obtained in step (2) to give a gelatin sheet; and (4) a step for seeding human corneal endothelial cells on the gelatin sheet obtained in step (3) to form a human corneal endothelial cell layer.
A peptide or pharmaceutically acceptable salt thereof selected from the group consisting of Ala-Hyp-Gly, Hyp-Gly-Pro, Leu-Hyp, Glu-Hyp, Gly-Pro-Hyp, Pro-Ala, Hyp-Gly, and Pro-Hyp having more excellent myoblast differentiation acceleration effect over prior art.
This photocurable material for sealing, which contains (A) an oligomer that contains a (meth)acryloyl group and has a weight average molecular weight of 10,000-30,000, (B) a (meth)acrylate monomer, (C) a polythiol compound, and if necessary, (D) a carbodiimide compound, has high recoverability from compression, high tensile strength, excellent flexibility, and if necessary, low hardness. Consequently, this photocurable material for sealing is capable of providing a sealing material that exhibits excellent sealing characteristics such as excellent airtightness and waterproof properties, while having less surface tackiness, and the like.
C08F 290/00 - Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
52.
PECTIN-CONTAINING ACIDIC MILK BEVERAGE AND PRODUCTION METHOD THEREOF
An aim is to provide a refreshing acidic milk beverage in which precipitation or aggregation is not produced and whey syneresis is reduced even in an acidic milk beverage having a low solids-not-fat concentration, and provided is an acidic milk beverage characterized by comprising an acidic milk beverage base and pectin having an intrinsic viscosity of 5.9 to 8.5, an esterification degree of 74 to 80 and a calcium reactivity of 230 or less.
5, Pro-Hyp, Hyp-Gly, Pro-Gly, Pro-Pro and Ala-Hyp or a chemically-modified substance thereof or a pharmaceutically acceptable salt thereof have DPPTV inhibitory activity and/or GLP-1 secretion accelerating activity, and hence are effective as a therapeutic or preventive agent or the like for diabetes.
C07K 5/062 - Dipeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/065 - Dipeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
C07K 5/072 - Dipeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 5/083 - Tripeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/087 - Tripeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
C07K 5/093 - Tripeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 5/097 - Tripeptides the first amino acid being heterocyclic, e.g. Pro, His, Trp, e.g. thyroliberin, melanostatin
54.
MATERIAL FOR PHOTOCURABLE SEALING, SEALING METHOD, SEALING MATERIAL, AND CASE USING SAME
This material for photocurable sealing contains (A) an oligomer that has an average molecular weight of 10,000-30,000, while containing a (meth)acryloyl group, (B) a (meth)acrylate monomer, (C) a polythiol compound, and if necessary, (D) a carbodiimide compound. This material for photocurable sealing has high recoverability from compression, high tensile strength, excellent flexibility, and if necessary, low hardness, and is thus capable of providing a sealing material that exhibits excellent sealing characteristics such as excellent airtightness and waterproof properties, while having less surface tackiness, and the like.
C08L 51/08 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A problem that the present invention is to solve is to provide: a main body of a peptide molecule which is effective for inhibition of various maladies such as osteoporosis, osteoarthritis and pressure ulcer, particularly, a dipeptide which is easy to absorb into a body in an intestine; a collagen peptide which comprises the dipeptide as an essential dipeptide; and a malady inhibitor which comprises the dipeptide as an essential effective component. As a means of solving such a problem, a collagen peptide according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential dipeptide. A dipeptide according to the present invention is characterized by having a structure of Hyp-Gly. A malady inhibitor according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential effective component.
A collagen peptide mixture containing three or more kinds selected from Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, chemically-modifiedsubstances thereof and pharmaceutically acceptable salts thereof, and at least one peptide selected from the group consisting of Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, Pro-Hyp-Gly, Leu-Hyp, Ile-Hyp, Ser-Hyp-Gly, Gly-Pro-Hyp, (Pro-Hyp-G1y)5, Pro-Hyp, Hyp-Gly, Pro-Gly, Pro-Pro and Ala-Hyp or a chemically-modified substance thereof or a pharmaceutically acceptable salt thereof have DPPIV inhibitory activity and/or GLP-1 secretion accelerating activity, and hence are effective as a therapeutic or preventive agent or the like for diabetes.
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 43/00 - Drugs for specific purposes, not provided for in groups
C07K 5/072 - Dipeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 5/093 - Tripeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
57.
THERAPEUTIC AGENT AND PREVENTIVE AGENT FOR DIABETES
A collagen peptide mixture containing three or more components selected from among Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, the chemically modified products thereof, and the pharmaceutically accepted salts thereof exerts DPPIV inhibitory activity and/or GLP-1 secretion-promoting activity, and thus is effective as a therapeutic agent or a preventive agent for diabetes. At least one peptide selected from among Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, Pro-Hyp-Gly, Leu-Hyp, Ile-Hyp, Ser-Hyp-Gly, Gly-Pro-Hyp, (Pro-Hyp-Gly)5, Pro-Hyp, Hyp-Gly, Pro-Gly, Pro-Pro, and Ala-Hyp exerts DPPIV inhibitory activity and/or GLP-1 secretion-promoting activity, and thus is effective as a therapeutic agent or a preventive agent for diabetes. Additionally, the chemically modified product of the aforementioned peptides, or the pharmaceutically accepted salt thereof exert DPPIV inhibitory activity and/or GLP-1 secretion-promoting activity, and thus are effective as a therapeutic agent or a preventive agent for diabetes.
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 43/00 - Drugs for specific purposes, not provided for in groups
C07K 5/072 - Dipeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 5/093 - Tripeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
Disclosed is at least one type of peptide molecule which, having a structure selected from (POG)5, G(POG)4, (POG)4, G(POG)3, (POG)3, G(POG)2, (POG)2, EGDGHLGKPGROGE, EKDGHPGKPGROGE, and pharmaceutically acceptable salts of these, is effective in suppressing various diseases such as osteoporosis, osteoarthritis and decubitus. Further, said peptide molecule migrates readily into cells and is readily absorbed into the body in the intestinal tract, and by having the property of strongly binding to nucleic acid compounds to form complexes, functions well as a carrier component that delivers nucleic acid compounds without causing problems associated with conventional DDS technology.
Various diseases such as osteoporosis, osteoarthritis and decubitus can effectively be suppressed by one or more peptide molecules selected from a group comprising EGDGHLGKPGROGE, EKDGHPGKPGROGE, G(POG)4, (POG)3, G(POG)2, (POG)2, (POG)4, (POG)5, G(POG)3 and pharmaceutically acceptable salts of these. The peptide molecules migrate readily into cells, are readily absorbed into the body in the intestinal tract, and strongly bind nucleic acid compounds and the like to form complexes, and thus function well as a carrier component for delivering nucleic acid compounds, without suffering from the problems associated with conventional DDS technology.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemical reagents for non-medical purposes, namely, chemical reagents for scientific and research purposes other than for medical or veterinary purposes; culture media for cultivating microbial cells for scientific and research purposes other than for medical or veterinary purposes; chemicals for use in industry; protein in the nature of gelatin in the form of liquid, sol, gel or powder for industrial use; protein in the nature of collagen in the form of liquid, sol, gel or powder for industrial use Gelatin for medical use, namely, used as hemostat agent; collagen for medical use, namely, used as hemostat agent; gelatin in the form of liquid, sol, gel or powder for medical use, namely, for making artificial blood vessels; collagen in the form of liquid, sol, gel or powder for medical use, namely, for making artificial blood vessels; gelatin in the form of liquid, sol, gel or powder for regenerating body tissue; collagen in the form of liquid, sol, gel or powder for regenerating body tissue; diagnostic reagents for medical use; microbial culture media for medical use; nutritional additives for medical purposes for use in foods and dietary supplements for human consumption; gelatin as an ingredient for pharmaceuticals as a carrier involved in the transportation of drugs and growth factors; collagen as an ingredient for pharmaceuticals as a carrier involved in the transportation of drugs and growth factors; materials for dental fillings and for sealing purposes
Disclosed is a method for forming a functional foam layer, by which adhesion between a primer layer and the functional foam layer is improved and sufficient curing in the deep portion of the functional layer that is composed of a foam can be achieved. Specifically disclosed is a method for forming a functional foam layer, which is characterized in that the surface of a base is provided with a coating film that forms a transparent primer layer, then an uncured functional foam layer is superposed on the coating film that forms a transparent primer layer and ultraviolet light is irradiated from the functional foam layer side toward the base surface, so that the transparent primer layer and the functional foam layer are cured at the same time, thereby carrying out the bonding between the base surface and the transparent primer layer and the bonding between the transparent primer layer and the functional foam layer at the same time.
B32B 5/18 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by features of a layer containing foamed or specifically porous material
B32B 37/00 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
A problem that the present invention is to solve is to provide: a main body of a peptide molecule which is effective for inhibition of various maladies such as osteoporosis, osteoarthritis and pressure ulcer, particularly, a dipeptide which is easy to absorb into a body in an intestine; a collagen peptide which comprises the dipeptide as an essential dipeptide; and a malady inhibitor which comprises the dipeptide as an essential effective component. As a means of solving such a problem, a collagen peptide according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential dipeptide. A dipeptide according to the present invention is characterized by having a structure of Hyp-Gly. A malady inhibitor according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential effective component.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
07 - Machines and machine tools
09 - Scientific and electric apparatus and instruments
Goods & Services
(1) Collagen dough for use in cutaneous regeneration; collagen paste for use in coating artificial blood vessels; collagen tubing and plates manufactured from animal skin and fillers used by others to demonstrate and validate surgical devices; collagen powder for producing additives in processed foods; edible collagen casings used in the manufacture of sausages; sausages making machines and parts therefor.
64.
SEALING MATERIAL AND METHOD OF FOAMING APPLICATION THEREOF
A sealing material which does not sag after application and shows excellent sealing performance even under severe high-temperature conditions. Even when used with foaming, the sealing material can form satisfactory closed cells therein. Also provided is a method of foaming application of the sealing material. The sealing material is characterized by comprising an ultraviolet-curable ingredient and an ultraviolet-polymerizable initiator, the content of any thermoplastic elastomer not curable with ultraviolet in the material being 5 wt.% or lower. It is further characterized in that the ultraviolet-curable ingredient comprises an acrylate which gives an ultraviolet-cured polymer having a glass transition temperature and a weight-average molecular weight in respective certain ranges, and that the sealing material has a melt viscosity at 120°C in a certain range. The method of sealing-material foaming application is characterized by thermally melting the sealing material, incorporating nitrogen gas into the molten sealing material at a given elevated pressure, ejecting the mixture in the air at a given pressure and applying it to an area needing sealing while foaming the mixture to thereby form a sealing foam, and curing the foam with ultraviolet.
A problem that the present invention is to solve is to provide: a main body of a peptide molecule which is effective for inhibition of various maladies such as osteoporosis, osteoarthritis and pressure ulcer, particularly, a dipeptide which is easy to absorb into a body in an intestine; a collagen peptide which comprises the dipeptide as an essential dipeptide; and a malady inhibitor which comprises the dipeptide as an essential effective component. As a means of solving such a problem, a collagen peptide according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential dipeptide. A dipeptide according to the present invention is characterized by having a structure of Hyp-Gly. A malady inhibitor according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential effective component.
Disclosed are: a peptide molecule itself which is effective for the prevention of a disease such as osteoporosis, osteoarthritis and bedsore, particularly a dipeptide which can be absorbed into a body readily through an intestine; a collagen peptide comprising the dipeptide as an essential dipeptide component; and an agent for preventing a disease, which comprises the dipeptide as an essential active ingredient. Specifically disclosed are: a collagen peptide characterized by comprising a dipeptide having a structure Hyp-Gly as an essential dipeptide component; a dipeptide characterized by having a structure Hyp-Gly; and an agent for preventing a disease, which comprises a dipeptide having a structure Hyp-Gly as an essential active ingredient.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
31 - Agricultural products; live animals
29 - Meat, dairy products, prepared or preserved foods
Goods & Services
Gelatine for industrial purposes, namely, glue; gelatine for use in photographic chemicals and developers; x-ray and photographic film processing chemicals and chemical compounds; protein used in the manufacture of food supplements and food products; gelatin for use in pharmaceuticals and for medical purposes, namely, gelatin in raw form used in the production of capsules for and tablets of pharmaceuticals and medicines [ protein supplements ] Gelatin, namely, protein as fodder and animal foodstuffs; gelatin, namely, protein for animal consumption Unflavored and unsweetened gelatins for use in food substances; gelatin, namely, protein being foodstuffs for human consumption; gelatin, namely, protein for use as a food additive
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
31 - Agricultural products; live animals
Goods & Services
(1) Gelatine for industrial purposes, namely, glue, gelatine for industrial purposes, namely, gelatine in raw form for use in the production of pharmaceutical capsule shells and pharmaceutical tablets, gelatine for industrial purposes, namely, gelatine in raw form for use in the production of capsule shells for nutritional supplements and nutritional supplements in the form of tablets; gelatine for medical purposes, namely, gelatine in raw form for use in the production of medicinal capsule shells and medicinal tablets; gelatine for food; unprocessed protein for use as a food additive for both human and animal consumption; prepared and processed protein for use as a food additive for both human and animal consumption.
