Abstract

The present invention relates to the preparation of compositions comprising benzoyl peroxide, with or without other additional active ingredients. The process involves introducing benzoyl peroxide, along with any other active ingredients present, into a fatty substance that contains and protects the ingredients that would otherwise be unstable when in contact with one another. The composition is designed to allow all ingredients to become available for skin contact or skin absorption when the fatty substance softens and/or melts as the composition is applied to the skin. The benzoyl peroxide may be pre-micronized to a particle distribution size of about dgo of 0.1 to 150 microns, preferably dgo of 10 to 15 microns.

IPC Classes  ?

• A01N 31/00 - Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
• A61K 31/075 - Ethers or acetals

Abstract

The present invention is directed to a process for the preparation of the saponification products of lactones, preferably three- to eight-membered lactones. The present invention is also directed to a process for the preparation of compounds having general formula (I): wherein M is selected from the group consisting of cationic species, preferably metal cations (even more preferably Na), from a compound having the formula (II): comprising reacting a compound having formula (II) with a suitable hydroxide salt (M-OH) (III) such as, preferably, sodium hydroxide, in an aqueous medium. The reaction preferably utilizes a continuous process method for the substantial consumption of reagent and continuous, semi-continuous, and/or batch-wise processing for final consumption of reagent.

IPC Classes  ?

• C07F 1/04 - Sodium compounds
• C07D 307/04 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
• C11D 15/02 - Apparatus therefor
• C11D 1/26 - Sulfonic acids or sulfuric acid estersSalts thereof derived from heterocyclic compounds