05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
pharmaceutical preparations for the treatment of respiratory disorders, ampoules and vials sold filled with medicated serums for the treatment of respiratory disorders
A vial adapter may include a body extending from a proximal end to a distal end. A syringe connector configured to engage a syringe may be proximate the proximal end of the body. A cannula configured to pierce a septum of a vial may be disposed proximate the distal end of the body. A vial attachment portion may be disposed at the distal end of the body. A fluid conduit may extend from an outlet aperture at the syringe connector to the cannula. A compressible member may be disposed within the syringe connector. The syringe connector may axially compress the compressible member from an expanded configuration, in which the compressible member blocks the outlet aperture and prevents fluid flow from the fluid conduit to the syringe connector, to a compressed configuration, in which the outlet aperture is exposed.
Injection monitoring circuitry is provided for coupling to part of an injection device having a syringe and a plunger rod. The injection monitoring circuitry has an input to receive force measurement data from a force sensor, the force measurement data includes a plurality of timestamped force measurements of force applied by a user to the injection device when an injection is administered to an injection site. Processing circuitry is provided to determine from the force measurement data when an end of injection has been reached, the end of injection corresponding to the plunger rod having reached an end position in a distal portion of the barrel of the syringe during administration of the injection by the user. Machine readable instructions and an injection monitoring method are also provided.
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
An injection device is described. The injection device includes a stopper having a first conductive element, a barrel having a medicament reservoir sealed at a proximal end with the stopper, and a plunger rod having a second conductive element. The plunger rod is coupled with the stopper to cause forward axial movement of the stopper to expel a medicament from the medicament reservoir. The first conductive element and the second conductive element complete an electrical circuit when the plunger rod is coupled to the stopper.
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
5.
Assembly for a medication delivery device and medication delivery device
An assembly for a medication delivery device includes a body, a piston rod, rotatable with respect to the body, for setting a dose of a medication, and axially movable in a distal direction for delivering the set dose, wherein, in cross-section, the piston rod includes a plurality of ratchet teeth to enable rotation of the piston rod during setting of a dose, and a stop member secured against axial and rotational movement, wherein the stop member mechanically cooperates with the piston rod, wherein, when setting the dose, the piston rod becomes aligned with the stop member, and wherein, when delivering the set dose, the piston rod is moved in the distal direction towards the stop member such that the piston rod and the stop member abut at the end of the dose delivery operation and further distal movement of the piston rod is prevented after dose delivery.
An assembly (47) for a medication delivery device (1) has a body (2), a dose setting part (8) configured to be operated by a user for selecting a size of a dose, a piston rod (13) configured to be moved axially without rotating for dispensing a medication, and a drive member (12) being directly coupled to the piston rod (13) for driving the piston rod (13) in a dose dispensing operation, wherein the drive member (12) moves in a proximal direction in a dose setting operation. The medication delivery device (1) into which the assembly is incorporated may be a single-shot, variable-dose injection device, e.g., a syringe.
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
Injection monitoring circuitry is provided for coupling to part of an injection device having a syringe and a plunger rod. The injection monitoring circuitry has an input to receive force measurement data from a force sensor, the force measurement data comprising a plurality of timestamped force measurements of force applied by a user to the injection device when an injection is administered to an injection site. Processing circuitry is provided to determine from the force measurement data when an end of injection has been reached, the end of injection corresponding to the plunger rod having reached an end position in a distal portion of the barrel of the syringe during administration of the injection by the user. Machine readable instructions and an injection monitoring method are also provided.
Injection monitoring circuitry is provided for coupling to part of an injection device having a syringe and a plunger rod. The injection monitoring circuitry has an input to receive force measurement data from a force sensor, the force measurement data comprising a plurality of timestamped force measurements of force applied by a user to the injection device when an injection is administered to an injection site. Processing circuitry is provided to determine from the force measurement data when an end of injection has been reached, the end of injection corresponding to the plunger rod having reached an end position in a distal portion of the barrel of the syringe during administration of the injection by the user. Machine readable instructions and an injection monitoring method are also provided.
An injection device (10) comprising: a. a barrel (11) having a medicament reservoir (15) therein capable of fluid communication with a needle assembly (12) at a distal end thereof and sealed at a proximal end thereof with a stopper (14); and b. a plunger rod (20) having a distal rod end (22) which is couplable with said stopper (14), wherein, when the plunger rod is coupled to the stopper, forward axial movement of the plunger rod (20) causes forward axial movement of the stopper (14) coupled thereto into the medicament reservoir (15) in order to expel medicament through the needle assembly (12), and the plunger rod can be decoupled from the stopper by applying a rearward axial force on the plunger rod, said rearward axial decoupling force being less than a rearward axial force required to move the stopper (14) rearwardly with respect to the barrel (11).
A61M 5/28 - Syringe ampoules or cartridges, i.e. ampoules or cartridges provided with a needle
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
An injection device (10) comprising: a. a barrel (11) having a medicament reservoir (15) therein capable of fluid communication with a needle assembly (12) at a distal end thereof and sealed at a proximal end thereof with a stopper (14); and b. a plunger rod (20) having a distal rod end (22) which is couplable with said stopper (14), wherein, when the plunger rod is coupled to the stopper, forward axial movement of the plunger rod (20) causes forward axial movement of the stopper (14) coupled thereto into the medicament reservoir (15) in order to expel medicament through the needle assembly (12), and the plunger rod can be decoupled from the stopper by applying a rearward axial force on the plunger rod, said rearward axial decoupling force being less than a rearward axial force required to move the stopper (14) rearwardly with respect to the barrel (11).
A61M 5/28 - Syringe ampoules or cartridges, i.e. ampoules or cartridges provided with a needle
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
An injection device including a barrel having a medicament reservoir therein capable of fluid communication with a needle assembly at a distal end thereof and sealed at a proximal end thereof with a stopper. The injection device further includes a plunger rod having a distal rod end which is couplable with said stopper, wherein, when the plunger rod is coupled to the stopper, forward axial movement of the plunger rod causes forward axial movement of the stopper coupled thereto into the medicament reservoir in order to expel medicament through the needle assembly. Further, the plunger rod can be decoupled from the stopper by applying a rearward axial force on the plunger rod, said rearward axial decoupling force being less than a rearward axial force required to move the stopper rearwardly with respect to the barrel.
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
Injection monitoring circuitry is provided for coupling to part of an injection device having a syringe and a plunger rod. The injection monitoring circuitry has an input to receive force measurement data from a force sensor, the force measurement data includes a plurality of timestamped force measurements of force applied by a user to the injection device when an injection is administered to an injection site. Processing circuitry is provided to determine from the force measurement data when an end of injection has been reached, the end of injection corresponding to the plunger rod having reached an end position in a distal portion of the barrel of the syringe during administration of the injection by the user. Machine readable instructions and an injection monitoring method are also provided.
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
G01L 5/00 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
13.
Assembly for a medication delivery device and medication delivery device comprising such an assembly
An assembly for a medication delivery device having a body, a piston rod and a setting nut. The piston rod is rotatable relative to the body in a dose setting state and is axially movable in a distal direction with respect to the body in a dose delivering state. The setting nut is secured against rotational movement with respect to the body, but is axially movable relative to the body, being helically coupled with the piston rod to axially travel in the proximal direction for setting a dose of a medication due to a helical movement of the setting nut with respect to the piston rod when the piston rod is rotated in the dose setting state, and is able to axially travel in the distal direction for delivering the set dose of the medication when the piston rod is axially moved in the dose delivering state of the assembly.
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
14.
Assembly for a medication delivery device and medication delivery device
An assembly for a medication delivery device, wherein the assembly is configured to perform a dose setting operation, the assembly having a dose setting sleeve and a drive sleeve, wherein the dose setting sleeve has a first dosing track having a first length and defining a first size of a dose and a second dosing track having a second length and defining a second size of a dose, wherein the first length is different from the second length and the first size is different from the second size. The drive sleeve has an engagement feature configured to engage with one of the dosing tracks. The assembly is configured such the dose setting operation has a first step wherein the engagement feature is aligned with one of the dosing tracks and a second step wherein the engagement feature is moved along the dosing track.
An injection device comprises a housing having a longitudinal axis, an axially-depressible dose button (430), a dose indicator (418), a dose setting mechanism operatively coupled to said dose indicator and capable of setting a dose to be ejected from the injection device and spring capable of storing energy necessary for ejecting the dose from the injection device. The spring (420) is coupled to the dose setting mechanism such that a charging force can be transferred from the dose setting mechanism to the spring to increase the energy stored by the spring. The dose setting mechanism comprises an assembly of three components, including: •a ratchet ring (410) rotationally and axially locked with respect to said housing, the ratchet ring including a ratchet component; •a drive plate (405) including a first set of splines forming a ratchet arrangement with said ratchet component; and•a dose selector (416) capable of being rotated about said longitudinal axis with respect to said housing to set the dose and including splines for disengaging said ratchet arrangement. The ratchet component is capable of interacting with both the splines on the dose selector and the splines on the drive plate.
An injection device comprising a housing having a longitudinal axis, a dose selector (16) capable of being rotated about said longitudinal axis with respect to said housing by a user to set a dose of medicament to be ejected from the injection device and a spring (20) capable of storing energy necessary for ejecting the dose of medicament from the injection device. The spring is coupled to the dose selector such that a charging force can be transferred from the dose selector to the spring to increase the energy stored by the spring. The injection device further comprises a ratchet arrangement (25) moveable between an engaged state in which the spring is limited from unwinding from a currently selected dose and a disengaged state in which the spring is able to unwind and a drive assembly including a plunger element (23) capable of providing an axial force for ejecting a dose of medicament from the injection device. The drive assembly further comprises a drive clutch (21) moveable from a disengaged state in which a force path from the spring to the plunger element is interrupted and an engaged state in which the drive assembly can provide the axial force for ejecting a dose of medicament from the injection device via said force path.
An injection device comprises a dose selector, rotatable by a user to set a dose to be ejected from the injection device and a drive assembly including a drive shaft (140) and a plunger element (145), the drive assembly being capable of providing an axial force for ejecting a dose of medicament from a medicament container. A dose limit nut (141) is provided which is rotationally coupled to but not axially coupled to said drive shaft. The plunger element is threaded so that the dose limit nut is engaged with said plunger element via said thread, in order to guide relative axial movement between the dose limit nut and the plunger element. The dose limit nut is provided with dose limiting endstops which are capable of limiting axial travel of said dose limit nut with respect to said plunger element, so as to limit maximum and minimum doses of medicament which can be set by the user. In addition, the dose limit nut comprises a last dose rotary endstop feature which prevents further rotation of said dose limit nut with respect to said drive shaft so as to prevent the user setting a dose that is greater than an injectable volume of medicament remaining in said medicament container.
An injection device comprises a housing having a first longitudinal axis (L). The injection device further comprises a medicament cartridge holder and a drive assembly including a drive shaft. The drive shaft is arranged around the first longitudinal axis. The drive assembly is capable of providing an axial force for ejecting a dose of medicament from the injection device. The medicament cartridge holder and at least part of said drive assembly are arranged around a second longitudinal axis (LC) which is substantially parallel to but offset from the first longitudinal axis.
An injection device comprising a housing (112), and a dose selector (116) operatively connectable to a dose indicator positioned within the housing. The dose selector and the dose indicator (118, 119) are capable of cooperating to set a dose to be ejected from the injection device. The injection device further comprises a spring (120) capable of storing energy necessary for ejecting the dose from the injection device. The spring is locked to the dose indicator such that a charging force can be transferred from the dose selector to the spring via the dose indicator to increase the energy stored by the spring.
An injection device comprises a housing (12) having a longitudinal axis. The injection device further comprises a dose selector (16) capable of setting a dose to be ejected from the injection device and a dose indicator comprising a units wheel (18) operatively connectable to the dose selector so that rotation of the dose selector about the longitudinal axis also rotates the units wheel, and a tens wheel (19) selectively engageable with the units wheel so that rotation of the units wheel also rotates the tens wheel. A biasing means biases the dose indicator axially-rearwardly in the housing. An internal surface of the housing is provided with a tens housing feature selectively engageable with the tens wheel to prevent rotation thereof. An internal surface of the housing is provided with a units housing feature capable of moving the units wheel axially-forward against said biasing means such that the units wheel engages and moves the tens wheel axially-forward and free of said tens housing feature so as to allow rotation thereof.
An injection device comprising a housing (12) and a dose selector (16) to set a dose of medicament to be ejected from the injection device. A spring (20) coupled to the dose selector stores energy necessary for ejecting the dose from the injection device. A ratchet (25) arrangement is provided to rotationally couple a ratchet component and an internal surface of the housing in a coupled state and to allow relative rotation between the ratchet component and the internal surface of the housing in an uncoupled state. An over-torque feature (27) located between the dose selector and the spring is actuatable, when the rotation of the dose selector causes the charging force to exceed a defined limit, to reduce the charging force transferred from the dose selector to the spring. Both the ratchet component and the over-torque feature are provided on a single component (28).
An injection device comprises a housing, a dose indicator positioned within the housing and a dose selector operatively connectable to the dose indicator. The dose selector and the dose indicator are capable of cooperating with one another to set a dose to be ejected from the injection device. The dose indicator comprises an odometer including: i. a units (218) wheel operatively connected to the dose selector so that rotation of the dose selector also rotates the units wheel, and ii. a tens wheel (219) selectively engageable with the units wheel so that rotation of the units wheel also rotates the tens wheel. The dose indicator further comprises an axially-moveable shuttle lock (222) rotationally locked to the tens wheel and selectively engageable with the units wheel and the housing. The tens wheel is selectively engageable with the units wheel via said shuttle lock and, when the tens wheel is not engaged with the units wheel, the shuttle lock is rotationally locked to the housing.
An assembly for a medication delivery device (1) is described comprising a body (3), a piston rod (4) adapted and arranged to be rotated with respect to the body (3) for setting a dose of a medication (10) and to be axially moved in a distal direction with respect to the body (3) for delivering the set dose of the medication (10), wherein, as seen in cross-sect ion, the piston rod (4) comprises a plurality of ratchet teeth (24) adapted and arranged to enable rotation of the piston rod (4) during setting of a dose of the medication (10), and at least one stop member (18) secured against axial and rotational movement with respect to the body (3), wherein the stop member (18) is adapted and arranged to mechanically cooperate with the piston rod (4), wherein when setting the dose of the medication (10), the piston rod (4) becomes aligned with the stop member (18), wherein when delivering the set dose, the piston rod (4) is moved in the distal direction towards the stop member (18) such that the piston rod (4) and the stop member (18) abut at the end of the dose delivery operation and such that further distal movement of the piston rod (4) is prevented after the set dose of the medication (10) was delivered. Furthermore, a medication delivery device (1) comprising the assembly is described.
An assembly (47) for a medication delivery device (1) comprises a body (2), a dose setting part (8) configured to be operated by a user for selecting a size of a dose, a piston rod (13) configured to be moved axially without rotating for dispensing a medication, and a drive member (12) being directly coupled to the piston rod (13) for driving the piston rod (13) in a dose dispense operation, wherein the drive member (12) moves in a proximal direction in the dose setting operation. A medication delivery device (1) comprising the assembly may be a single-shot variable- dose injection device.
The present invention concerns an assembly for a medication delivery device (1), wherein the assembly is configured to perform a dose setting operation, wherein the assembly comprises a dose setting sleeve (5) and a drive sleeve (2), wherein the dose setting sleeve (5) comprises a first dosing track (56) having a first length and defining a first size of a dose and a second dosing track (57) having a second length and defining a second size of a dose, wherein the first length is different from the second length and the first size is different from the second size, wherein the drive sleeve (2) comprises an engagement feature (37) configured to engage with one of the dosing tracks (56, 57), and wherein the assembly is configured such the dose setting operation comprises a first step wherein the engagement feature (37) is aligned with one of the dosing tracks (56, 7) and a second step wherein the engagement feature (37) is moved along the dosing track (56, 57).
The present disclosure relates to an assembly for a medication delivery device (1). The assembly comprises a body (2), a piston rod (3) and a setting nut (4). The piston rod (3) is adapted and arranged to be rotated with respect to the body (2) in a dose setting state of the assembly for setting a dose of a medication (12) and to be axially moved in a distal direction with respect to the body (2) in a dose delivering state of the assembly for delivering the set dose of the medication (12). The setting nut (4) is secured against rotational movement with respect to the body (2), but enabled for axial movement with respect to the body (2), and further helically coupled with the piston rod (3). The setting nut (4) is adapted and arranged to axially travel in the proximal direction with respect to the body (2) for setting a dose of a medication (12) due to a helical movement of the setting nut (4) with respect to the piston rod (3) when the piston rod (3) is rotated with respect to the body (2) in the dose setting state of the assembly. Moreover, the setting nut (4) is adapted and arranged to axially travel in the distal direction with respect to the body (2) for delivering the set dose of the medication (12) when the piston rod (3) is axially moved in the distal direction with respect to the body (2) in the dose delivering state of the assembly.
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
Packaging for an injection device, the packaging including a channel extending longitudinally to accommodate the injection device, the channel including a longitudinal wall adjoining a base wall; a handling recess extending laterally and formed through the longitudinal wall, a positioning rib extending longitudinally and protruding from the base wall into the channel for insertion into a positioning recess of the injection device, the positioning rib arranged offset laterally from the recess and extending in a longitudinal field defined by the handling recess.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
B65D 71/20 - Slits or openings along the foldline of the tubular body
An injection device comprises a housing having a longitudinal axis, an axially-depressible dose button (430), a dose indicator (418), a dose setting mechanism operatively coupled to said dose indicator and capable of setting a dose to be ejected from the injection device and spring capable of storing energy necessary for ejecting the dose from the injection device. The spring (420) is coupled to the dose setting mechanism such that a charging force can be transferred from the dose setting mechanism to the spring to increase the energy stored by the spring. The dose setting mechanism comprises an assembly of three components, including: • a ratchet ring (410) rotationally and axially locked with respect to said housing, the ratchet ring including a ratchet component; • a drive plate (405) including a first set of splines forming a ratchet arrangement with said ratchet component; and • a dose selector (416) capable of being rotated about said longitudinal axis with respect to said housing to set the dose and including splines for disengaging said ratchet arrangement. The ratchet component is capable of interacting with both the splines on the dose selector and the splines on the drive plate.
An injection device comprises a housing, a dose indicator positioned within the housing and a dose selector operatively connectable to the dose indicator. The dose selector and the dose indicator are capable of cooperating with one another to set a dose to be ejected from the injection device. The dose indicator comprises an odometer including: i. a units (218) wheel operatively connected to the dose selector so that rotation of the dose selector also rotates the units wheel, and ii. a tens wheel (219) selectively engageable with the units wheel so that rotation of the units wheel also rotates the tens wheel. The dose indicator further comprises an axially-moveable shuttle lock (222) rotationally locked to the tens wheel and selectively engageable with the units wheel and the housing. The tens wheel is selectively engageable with the units wheel via said shuttle lock and, when the tens wheel is not engaged with the units wheel, the shuttle lock is rotationally locked to the housing.
An injection device comprises a housing (12) having a longitudinal axis. The injection device further comprises a dose selector (16) capable of setting a dose to be ejected from the injection device and a dose indicator comprising a units wheel (18) operatively connectable to the dose selector so that rotation of the dose selector about the longitudinal axis also rotates the units wheel, and a tens wheel (19) selectively engageable with the units wheel so that rotation of the units wheel also rotates the tens wheel. A biasing means biases the dose indicator axially-rearwardly in the housing. An internal surface of the housing is provided with a tens housing feature selectively engageable with the tens wheel to prevent rotation thereof. An internal surface of the housing is provided with a units housing feature capable of moving the units wheel axially-forward against said biasing means such that the units wheel engages and moves the tens wheel axially-forward and free of said tens housing feature so as to allow rotation thereof.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
An injection device comprises a housing having a first longitudinal axis (L). The injection device further comprises a medicament cartridge holder and a drive assembly including a drive shaft. The drive shaft is arranged around the first longitudinal axis. The drive assembly is capable of providing an axial force for ejecting a dose of medicament from the injection device. The medicament cartridge holder and at least part of said drive assembly are arranged around a second longitudinal axis (LC) which is substantially parallel to but offset from the first longitudinal axis.
An injection device comprising a housing (12) and a dose selector (16) to set a dose of medicament to be ejected from the injection device. A spring (20) coupled to the dose selector stores energy necessary for ejecting the dose from the injection device. A ratchet (25) arrangement is provided to rotationally couple a ratchet component and an internal surface of the housing in a coupled state and to allow relative rotation between the ratchet component and the internal surface of the housing in an uncoupled state. An over-torque feature (27) located between the dose selector and the spring is actuatable, when the rotation of the dose selector causes the charging force to exceed a defined limit, to reduce the charging force transferred from the dose selector to the spring. Both the ratchet component and the over-torque feature are provided on a single component (28).
An injection device comprises a dose selector, rotatable by a user to set a dose to be ejected from the injection device and a drive assembly including a drive shaft (140) and a plunger element (145), the drive assembly being capable of providing an axial force for ejecting a dose of medicament from a medicament container. A dose limit nut (141) is provided which is rotationally coupled to but not axially coupled to said drive shaft. The plunger element is threaded so that the dose limit nut is engaged with said plunger element via said thread, in order to guide relative axial movement between the dose limit nut and the plunger element. The dose limit nut is provided with dose limiting endstops which are capable of limiting axial travel of said dose limit nut with respect to said plunger element, so as to limit maximum and minimum doses of medicament which can be set by the user. In addition, the dose limit nut comprises a last dose rotary endstop feature which prevents further rotation of said dose limit nut with respect to said drive shaft so as to prevent the user setting a dose that is greater than an injectable volume of medicament remaining in said medicament container.
An injection device comprising a housing having a longitudinal axis, a dose selector (16) capable of being rotated about said longitudinal axis with respect to said housing by a user to set a dose of medicament to be ejected from the injection device and a spring (20) capable of storing energy necessary for ejecting the dose of medicament from the injection device. The spring is coupled to the dose selector such that a charging force can be transferred from the dose selector to the spring to increase the energy stored by the spring. The injection device further comprises a ratchet arrangement (25) moveable between an engaged state in which the spring is limited from unwinding from a currently selected dose and a disengaged state in which the spring is able to unwind and a drive assembly including a plunger element (23) capable of providing an axial force for ejecting a dose of medicament from the injection device. The drive assembly further comprises a drive clutch (21) moveable from a disengaged state in which a force path from the spring to the plunger element is interrupted and an engaged state in which the drive assembly can provide the axial force for ejecting a dose of medicament from the injection device via said force path.
An injection device comprising a housing (112), and a dose selector (116) operatively connectable to a dose indicator positioned within the housing. The dose selector and the dose indicator (118, 119) are capable of cooperating to set a dose to be ejected from the injection device. The injection device further comprises a spring (120) capable of storing energy necessary for ejecting the dose from the injection device. The spring is locked to the dose indicator such that a charging force can be transferred from the dose selector to the spring via the dose indicator to increase the energy stored by the spring.
The present disclosure relates to a device (1) for sampling and/or injection of a radioactive solution (S) in a vial (2), wherein the vial (2) comprises an opening closed by a puncturable closure member (3). The device (1) comprises a container (7) adapted to receive said vial (2) and a vial adaptor (4), said vial adaptor (4) having a longitudinal axis (L1), provided at a first end (41) with a hollow spike (42) adapted to pierce said puncturable closure member (3) when the vial adaptor (4) is mounted on the vial (2), and at a second end (43) with connection means (5) adapted for its removable connection to a syringe (6), the container (7) comprising: - a container body (71) adapted to receive said vial (2), the container body (71) having an opening (711), and - a vial adaptor support structure (72) configured for being mounted onto the opening (711) of the container body (71), and comprising retention means configured for enabling releasable retention of said vial adaptor (4) within said vial adaptor support structure (72), and wherein the vial adaptor support structure (72) and the container body (71) are made at least partially of a radioprotective material for providing protection against ionizing radiation.
The present invention provides a process for preparing a particulate medicament that has greater homogeneity and a lower adhesion between the particles of the active ingredient and the carrier. The process comprises the steps of: (a) combining a pharmaceutically active ingredient in the form of an agglomerate of primary particles having an agglomerate particle size such that the agglomerate is capable of passing through a sieve having a mesh of 50-3000 .mu.m with a pharmaceutically acceptable particulate carrier, and (b) mixing the resultant material in a mixer to break up the agglomerate into primary particles dispersed in the pharmaceutically acceptable particulate carrier such that 90% or more of the pharmaceutically active ingredient exists as primary particles having a particle size of 50 .mu.m or less.
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A dry powder inhalation apparatus includes a housing, a reservoir for medicament located within the housing, a mouthpiece disposed on the housing for insertion in the mouth of a user for inhalation of a predetermined dose of medicament, a delivery channel between a discharge outlet of the reservoir and the mouthpiece for delivering the predetermined dose of medicament, a device positioned within the housing and normally held adjacent the reservoir for receiving the predetermined dose of medicament from the discharge outlet and transferring it to the delivery channel, and a release mechanism adapted to release the device and permit controlled movement thereof to the delivery channel for the delivery, the release mechanism being located at least partially outside of the housing for manual operation by the user.
An airflow adaptor for a breath-actuated dry powder inhaler. The airflow adaptor includes a conduit having a proximal end and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the conduit, and wherein the airflow adaptor further includes provisions for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor.
The present invention provides a solution formulation for inhalation from a nebuliser consisting of tiotropium, water, sodium chloride and an acid selected from HCl and citric acid, or a mixture thereof.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/439 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
The present invention provides a process for preparing a particulate medicament that has greater homogeneity and a lower adhesion between the particles of the active ingredient and the carrier. The process comprises the steps of: (a) combining a pharmaceutically active ingredient in the form of an agglomerate of primary particles having an agglomerate particle size such that the agglomerate is capable of passing through a sieve having a mesh of 50-3000 .mu.m with a pharmaceutically acceptable particulate carrier, and (b) mixing the resultant material in a mixer to break up the agglomerate into primary particles dispersed in the pharmaceutically acceptable particulate carrier such that 90% or more of the pharmaceutically active ingredient exists as primary particles having a particle size of 50 .mu.m or less.
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A dispensing mechanism for administering a dosage of a medicament includes dosage setting means (7) for setting the dosage of a medicament to be administered; expelling means (15) for expelling a medicament from a medicament container; and coupling means (21) operatively coupled with the dosage setting means (7) and the expelling means (15), wherein the coupling means (21) is arranged to convert displacement of the dosage setting means (7) into a displacement of the expelling means (15) in a first direction, wherein the expelling means (15) includes a ratchet means (18a, 18b), and wherein the mechanism includes a first and a second independently moveable resisting pawl (14a, 14b) means facing a common side of the ratchet means (18), the first and the second resisting pawl means (14a, 14b) being configured to engage with the ratchet means (18a, 18b) and resist displacement of the expelling means (15) in a second direction opposite to said first direction.
A dispensing mechanism for administering a dosage of a medicament includes dosage setting means (7) for setting the dosage of a medicament to be administered; expelling means (15) for expelling a medicament from a medicament container; and coupling means (21) operatively coupled with the dosage setting means (7) and the expelling means (15), wherein the coupling means (21) is arranged to convert displacement of the dosage setting means (7) into a displacement of the expelling means (15) in a first direction, wherein the expelling means (15) includes a ratchet means (18a, 18b), and wherein the mechanism includes a first and a second independently moveable resisting pawl (14a, 14b) means facing a common side of the ratchet means (18), the first and the second resisting pawl means (14a, 14b) being configured to engage with the ratchet means (18a, 18b) and resist displacement of the expelling means (15) in a second direction opposite to said first direction.
A dispensing mechanism for administering a dosage of a medicament includes dosage setting means (7) for setting the dosage of a medicament to be administered; expelling means (15) for expelling a medicament from a medicament container; and coupling means (21) operatively coupled with the dosage setting means (7) and the expelling means (15), wherein the coupling means (21) is arranged to convert displacement of the dosage setting means (7) into a displacement of the expelling means (15) in a first direction, wherein the expelling means (15) includes a ratchet means (18a, 18b), and wherein the mechanism includes a first and a second independently moveable resisting pawl (14a, 14b) means facing a common side of the ratchet means (18), the first and the second resisting pawl means (14a, 14b) being configured to engage with the ratchet means (18a, 18b) and resist displacement of the expelling means (15) in a second direction opposite to said first direction.
A dispensing mechanism for administering a dosage of a medicament includes dosage setting means (7) for setting the dosage of a medicament to be administered; expelling means (15) for expelling a medicament from a medicament container; and coupling means (21) operatively coupled with the dosage setting means (7) and the expelling means (15), wherein the coupling means (21) is arranged to convert displacement of the dosage setting means (7) into a displacement of the expelling means (15) in a first direction, wherein the expelling means (15) includes a ratchet means (18a, 18b), and wherein the mechanism includes a first and a second independently moveable resisting pawl (14a, 14b) means facing a common side of the ratchet means (18), the first and the second resisting pawl means (14a, 14b) being configured to engage with the ratchet means (18a, 18b) and resist displacement of the expelling means (15) in a second direction opposite to said first direction.
An airflow adaptor for a breath-actuated dry powder inhaler. The airflow adaptor includes a conduit having a proximal end and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the conduit, and wherein the airflow adaptor further includes provisions for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor.
This invention provides a pharmaceutical solution formulation comprising tobramycin, water, sodium chloride and sodium citrate, wherein the formulation has a pH of 4.5-7.0 and an osmolality of 135-200 mOsmol/Kg.
A01N 43/04 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom
A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
This invention provides a pharmaceutical solution formulation comprising tobramycin, water, sodium chloride and sodium citrate, wherein the formulation has a pH of 4.5-7.0 and an osmolality of 135-200 mOsmol/Kg.
A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
A61K 9/72 - Medicinal preparations characterised by special physical form for smoking or inhaling
A61K 9/00 - Medicinal preparations characterised by special physical form
An inhaler for delivering dry-powder medicament to a patient from an open blister pocket of a blister pack. The inhaler includes a housing for enclosing used and unused portions of the blister pack together with a medicament dispensing mechanism. The inhaler also includes a manifold through which air can be drawn in use of the inhaler, the manifold including an air inlet for receiving external air, at least one medicament aperture for communicating with an opened pocket of the blister pack to enable entrainment of the medicament by the air drawn through the manifold, and an air outlet for delivery of the entrained medicament to the patient. The medicament dispensing mechanism includes a guide surface for guiding the cover sheet of the unused portion of the blister pack. The manifold and the guide surface are defined by separate components of the inhaler.
An inhaler for delivering dry-powder medicament to a patient from an open blister pocket of a blister pack. The blister pack is in the form of a flexible elongate strip including a base sheet having a plurality of recesses spaced along its length and a cover sheet peelably sealed to the base sheet to define a plurality of blister pockets each containing a measured dose of the medicament. The inhaler also includes a housing for enclosing used and unused portions of the blister pack together with the medicament dispensing mechanism. The housing defines internal transverse walls extending in the width direction of the blister pack for isolating the used portion of the cover sheet from the unused portion of the blister pack.
An inhaler for delivering dry-powder medicament to a patient from an open blister pocket of a blister pack. The blister pack has a plurality of blister pockets spaced apart in a length direction of the pack and each containing a measured dose of the medicament. The inhaler includes a housing for enclosing used and unused portions of the blister pack together with a medicament dispensing mechanism for opening the blister pockets of the blister pack. The inhaler also includes a manifold through which air can be drawn in use of the inhaler, the manifold including an air inlet for receiving external air, at least one medicament aperture for communicating with an opened pocket of the blister pack to enable entrainment of the medicament by the air drawn through the manifold, and an air outlet for delivery of the entrained medicament to the patient.
A container for re-suspending sedimented medicament comprises a reservoir for containing a suspension of particles in a liquid, a dispensing portion, and a sealing portion. The sealing portion is arranged to be in fluid communication with the reservoir via an orifice. The orifice is positioned between the dispensing portion and the sealing portion, and allows a turbulent flow of the liquid from the reservoir into the sealing portion to enable re-suspension of particles that have sedimented out of the liquid in the sealing portion.
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
B01F 5/06 - Mixers in which the components are pressed together through slits, orifices, or screens
B65D 1/02 - Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms
B01F 13/00 - Other mixers; Mixing plant, including combinations of dissimilar mixers
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical products and substances, for preventing or
treating respiratory diseases and disorders, including
asthma. Inhalation devices, inhalers, dose inhalers; parts,
components and fittings for the aforementioned products.
60.
AIRFLOW ADAPTOR FOR A BREATH-ACTUATED DRY POWDER INHALER
An airflow adaptor (200) for a breath-actuated dry powder inhaler. The airflow adaptor comprises a conduit (202) having a proximal end (201) and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the conduit, and wherein the airflow adaptor further comprises means (204, 205, 206, 210, 211, 212) for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor.
An airflow adaptor for a breath-actuated dry powder inhaler. The airflow adaptor includes a conduit having a proximal end and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the conduit, and wherein the airflow adaptor further includes provisions for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor.
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
B05D 7/14 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to metal, e.g. car bodies
B65D 83/06 - Containers or packages with special means for dispensing contents for dispensing powdered or granular material
62.
Inhalable solid amorphous particles comprising tiotropium bromide and a co-solid
An inhalable medicament is provided, in particular a new solid-state form of tiotropium bromide. The medicament can be in the form of solid amorphous particles containing an intimate admixture of tiotropium bromide together with a pharmaceutically acceptable co-solid having a glass transition temperature of at least −50° C., such as a sugar and/or sugar alcohol.
An inhaler (101) for delivering dry-powder medicament to a patient from an open blister pocket (3) of a blister pack (1). The blister pack (1) has a plurality of blister pockets (3) spaced apart in a length direction of the pack (1) and each containing a measured dose of the medicament. The inhaler (101) comprises a housing (103, 105) for enclosing used and unused portions of the blister pack (1) together with a medicament dispensing mechanism (119) for opening the blister pockets (3) of the blister pack (1). The inhaler (101) also comprises a manifold through which air can be drawn in use of the inhaler (101), the manifold comprising an air inlet (125) for receiving external air, at least one medicament aperture (127) for communicating with an opened pocket (3) of the blister pack (1) to enable entrainment of the medicament by the air drawn through the manifold, and an air outlet (129) for delivery of the entrained medicament to the patient.
An inhaler (101) for delivering dry-powder medicament to a patient from an open blister pocket (3) of a blister pack (1). The inhaler (101) comprises a housing (103, 105) for enclosing used and unused portions of the blister pack (1) together with a medicament dispensing mechanism. The inhaler (101) also comprises a manifold through which air can be drawn in use of the inhaler (101), the manifold comprising an air inlet (125) for receiving external air, at least one medicament aperture (127) for communicating with an opened pocket (3) of the blister pack (1) to enable entrainment of the medicament by the air drawn through the manifold, and an air outlet (129) for delivery of the entrained medicament to the patient. The medicament dispensing mechanism comprises a guide surface (117) for guiding the cover sheet (7) of the unused portion of the blister pack (1). The manifold and the guide surface (117) are defined by separate components of the inhaler (101).
An inhaler (101) for delivering dry-powder medicament to a patient from an open blister pocket (3) of a blister pack (1). The blister pack (1) is in the form of a flexible elongate strip comprising a base sheet (5) having a plurality of recesses spaced along its length and a cover sheet (7) peelably sealed to the base sheet (5) to define a plurality of blister pockets (3) each containing a measured dose of the medicament. The inhaler (101) also comprises a housing (103, 105) for enclosing used and unused portions of the blister pack (1) together with the medicament dispensing mechanism. The housing (103, 105) defines internal transverse walls (139) extending in the width direction of the blister pack (1) for isolating the used portion of the cover sheet (7) from the unused portion of the blister pack (1).
An inhaler (101) for delivering dry-powder medicament to a patient from an open blister pocket of a blister pack. The inhaler comprises: a dose counter including a display aperture (121) formed in the housing (103, 105); a display element (147) having dose counting indicia and the display element being mounted inside the housing such that a succession of the dose counting indicia are sequentially visible through the display aperture. The display aperture formed in the housing is provided with a magnifying lens arranged to magnify the dose counting indicia of the display element.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations and substances for use in the prevention or treatment of respiratory illnesses or respiratory disorders, including asthma. Inhalation devices, inhaler, metered dose inhalers; parts, components and fittings for the aforesaid goods.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations and substances; pharmaceutical preparations and substances for use in the prevention or treatment of allergies; pharmaceutical preparations and substances for use in the prevention or treatment of allergic rhinitis; pharmaceutical preparations and substances for use in nasal inhaler devices; solution for nasal inhalation after nebulisation; preparations and substances for nasal inhalation for nebulisation; all of the above products being delivered nasally; all of the aforesaid being for use in the treatment of allergies; none of the aforesaid being for use in the treatment of nausea or vomiting. Surgical, medical, dental and diagnostic apparatus, devices and instruments; inhalation devices, inhalers, metered dose inhalers, dry powder inhalers, aerosol inhalers and aqueous inhalers, all for the treatment of allergies; nebulisers; parts, fittings and components for the aforesaid goods; all of the aforesaid being for use in the treatment of allergies; none of the aforesaid being for use in the treatment of nausea or vomiting.
This invention relates to a dry powder medicament and particularly to a medicament which provides improved fine particle fraction. The method for preparing the inhalable dry-powder medicament comprises the steps of: (i) fractionating a particulate active ingredient based on aerodynamic particle size, (ii) recovering at least one fraction of the particulate active ingredient and (iii) combining the recovered fraction with a carrier to provide the inhalable dry-powder medicament. A dry-powder medicament per se is also described.
This invention relates to an inhalable medicament and in particular to a solid- state form of tiotropium bromide, namely solid amorphous particles comprising an intimate admixture of tiotropium bromide together with a pharmaceutically accept-able co-solid having a glass transition temperature of at least - 50°C, such as a sugar and/or a sugar derivative.
This invention relates to an inhalable medicament and in particular to a solid-state form of tiotropium bromide, namely solid amorphous particles comprising an intimate admixture of tiotropium bromide together with a pharmaceutically acceptable co-solid having a glass transition temperature of at least -50°C, such as a sugar and/or a sugar derivative.
The invention relates to dry powder inhalation apparatus usually operable by breath of a user which provides for controlled and smooth transfer of medicament during multiple actuations by a user. A mechanism of the apparatus for achieving this controlled and smooth transfer includes a device (4) normally held adjacent a reservoir for receiving medicament in a cup or receptacle (15) and which is generally movable transversely of a longitudinal axis of the apparatus to delivery channels of the apparatus. This bodily shifting of the device (4) is achieved by a yoke acting on an abutment (16) thereof. Spillage of medicament in the apparatus is avoided.
The present invention provides a method for preparing a sterile suspension of a glucocorticosteroid. The glucocorticosteroids used in the invention are preferably antiinflammatory glucocorticosteroids. By making the last stage of product preparation be the sterilization process, the potential for contamination during manufacture and heat degradation of products is greatly reduced.
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
An inhaler for administering a predetermined dose of a medicament. The inhaler includes a screw-threaded mechanism which is operable to dispense the predetermined dose for inhalation. The inhaler can include a rotatable threaded member mounted within a casing. The inhaler can also include an internally threaded sleeve mounted on the rotatable threaded member. The sleeve can be moved linearly by rotation of the threaded member. Medicament can be provided in a tray of the sleeve, and can be aligned with a mouth piece of the inhaler for inhalation by the linear movement of the sleeve.
The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing-effective time. The methods and compositions according to the invention are useful as therapeutic tools to prevent, reverse, and/or reduce the symptoms of allergic and/or inflammatory conditions in a mammalian patient. The invention also provides methods and compositions, which may be manipulated and fine-tuned to fit the condition(s) to be treated while producing fewer side effects.
A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
A61L 2/00 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lensesAccessories therefor
C07J 5/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, and substituted in position 21 by only one singly bound oxygen atom
The present invention provides a process for preparing a particulate medicament that has greater homogeneity and a lower adhesion between the particles of the active ingredient and the carrier. The process comprises the steps of: (a) combining a pharmaceutically active ingredient in the form of an agglomerate of primary particles having an agglomerate particle size such that the agglomerate is capable of passing through a sieve having a mesh of 50-3000 μm with a pharmaceutically acceptable particulate carrier, and (b) mixing the resultant material in a mixer to break up the agglomerate into primary particles dispersed in the pharmaceutically acceptable particulate carrier such that 90% or more of the pharmaceutically active ingredient exists as primary particles having a particle size of 50 μm or less.
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
77.
A PHARMACEUTICAL FORMULATION COMPRISING A BETA2-SELECTIVE ADRENOREZEPTOR AGONIST AND / OR GLUCOCORTICOID AND METHOD FOR THE PREPARATION THEREOF
This invention relates to minimising the degradation of β2-selective adrenoreceptor agonists and/or glucocorticosteroids. The invention provides a process for preparing a pharmaceutical dosage form of β2-selective adrenoreceptor agonists and/or glucocorticosteroids and/or a pharmaceutically acceptable salts thereof, wherein the β2-selective adrenoreceptor agonists and/or glucocorticosteroids and/or pharmaceutically acceptable salts thereof forms an aldehyde derivative upon oxidative degradation, which comprises: (a) providing water containing less than 12 쎽g/L of iron and chromium metal ions based on the total weight of the metal ions and the total volume of water, (b) combining the water with the β2-selective adrenoreceptor agonist and/or glucocorticosteroid and/or a pharmaceutically acceptable salt thereof to form an aqueous solution in a vessel, which vessel having one or more surfaces in contact with the water, wherein the surfaces are composed of a material which is substantially free of iron and chromium metal ions, and (c) packaging the aqueous solution in one or more containers.
A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A nasal spray device comprising a reservoir for a medicament, said reservoir having a neck portion disposed at an angle in relation to a vertical plane and a base portion; a spray pump dispenser having a dip tube; a means for attaching the spray pump dispenser to the neck portion; the spray pump dispenser and the reservoir are arranged so that the dip tube extends to the base portion and allows consistent dosing throughout the dosage regime up to exhaustion of the medicament volume.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical products; medication for the treatment of respiratory disorders; filled ampoules of pharmaceutical preparations. Vials and containers for medical and pharmaceutical purposes; surgical and medical apparatus, instruments and appliances; parts and fittings for all the aforesaid goods; none of the aforesaid goods being for dental surgical or orthodontic use.
A container (10) comprising a reservoir (20) containing a suspension of particles in a liquid, a dispensing portion (30) and a sealing portion (50) , said sealing portion (50) being arranged to be in fluid communication with the reservoir (20) via an orifice (40) , said orifice (40) being positioned between the dispensing portion (30) and the sealing portion (50) and allowing flow of the liquid from the reservoir (20) into the sealing portion (50) to enable re-suspension of particles that have sedimented out of the liquid in the sealing portion (50) .
A container (10) comprising a reservoir (20) containing a suspension of particles in a liquid, a dispensing portion (30) and a sealing portion (50) , said sealing portion (50) being arranged to be in fluid communication with the reservoir (20) via an orifice (40) , said orifice (40) being positioned between the dispensing portion (30) and the sealing portion (50) and allowing flow of the liquid from the reservoir (20) into the sealing portion (50) to enable re-suspension of particles that have sedimented out of the liquid in the sealing portion (50) .
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical, medicinal, medical, veterinary and sanitary
preparations and substances; pharmaceutical preparations and
substances for use in the prevention or treatment of
respiratory conditions, illnesses or respiratory disorders
including asthma, bronchitis, emphysema and COPD;
pharmaceutical preparations and substances for use in
respiratory inhaler devices; solutions for oral inhalation
after nebulisation; preparations and substances for oral
inhalation for nebulisation; suspensions for oral inhalation
for nebulisation. Surgical, medical, dental, veterinary and diagnostic
apparatus, devices and instruments; inhalation devices,
inhalers, metered dose inhalers, dry powder inhalers,
aerosol inhalers and aqueous inhalers, all for the treatment
of respiratory conditions or ailments; nebulisers; parts,
components and fittings for the aforesaid goods.
The present invention provides a method for preparing a sterile suspension of a glucocorticosteroid. The glucocorticosteroids used in the invention are preferably anti~inflammatory glucocorticosteroids. By making the last stage of product preparation be the sterilization process, the potential for contamination during manufacture and heat degradation of products is greatly reduced.
A61K 9/72 - Medicinal preparations characterised by special physical form for smoking or inhaling
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing- effective time. The methods and compositions according to the invention are useful as therapeutic tools to prevent, reverse, and/or reduce the symptoms of allergic and/or inflammatory conditions in a mammalian patient. The invention also provides methods and compositions, which may be manipulated and fine- tuned to fit the condition(s) to be treated while producing fewer side effects.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations and substances for use in the prevention or treatment of allergies; pharmaceutical preparations and substances for use in the prevention or treatment of allergic rhinitis; pharmaceutical preparations and substances for use in nasal inhaler devices; solution for nasal inhalation after nebulisation; preparations and substances for nasal inhalation for nebulisation; all of the above products being delivered nasally; all of the aforesaid being for use in the treatment of allergies; none of the aforesaid being for use in the treatment of nausea or vomiting. Surgical, medical, dental, veterinary and diagnostic apparatus, devices and instruments; inhalation devices, inhalers, metered dose inhalers, dry powder inhalers, aerosol inhalers and aqueous inhalers, all for the treatment of allergies; nebulisers; parts, fittings and components for the aforesaid goods; all of the aforesaid being for use in the treatment of allergies; none of the aforesaid being for use in the treatment of nausea or vomiting.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical, medicinal, medical, veterinary and sanitary preparations and substances; pharmaceutical preparations and substances for use in the prevention or treatment of respiratory conditions, illnesses or respiratory disorders including asthma, bronchitis, emphysema and COPD; pharmaceutical preparations and substances for use in respiratory inhaler devices; sterile solutions for use in nebulisers. Surgical, medical, dental, veterinary and diagnostic apparatus, devices and instruments; inhalation devices; inhalation devices for medical use; inhalers; metered dose inhalers; dry powder inhalers; aerosol inhalers; aqueous inhalers; nebulisers.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical, medicinal, medical, veterinary and sanitary preparations and substances; pharmaceutical preparations and substances for use in the prevention or treatment of respiratory conditions, illnesses or respiratory disorders including asthma, bronchitis, emphysema and COPD; pharmaceutical preparations and substances for use in respiratory inhaler devices; solution for oral inhalation after nebulisation; preparations and substances for oral inhalation for nebulisation; suspensions for oral inhalation for nebulisation. Surgical, medical, dental, veterinary and diagnostic apparatus, devices and instruments; inhalation devices, inhalers, metered dose inhalers, dry powder inhalers, aerosol inhalers and aqueous inhalers, all for the treatment of respiratory conditions or ailments; nebulisers; parts, components and fittings for the aforesaid goods.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations and substances. Medical apparatus and instruments; inhaler devices; inhaler devices for medical use; metered dose inhalers, dry powder inhalers, aerosol inhalers and aqueous inhalers, all for use in the treatment of respiratory conditions or ailments; nebulisers; parts, components and fittings for the aforesaid goods.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations and substances for use in the prevention or treatment of respiratory conditions, illnesses or respiratory disorders including asthma, bronchitis, emphysema and COPD; pharmaceutical preparations and substances for use in respiratory inhaler devices; sterile solutions for use in nebulisers. Surgical, medical, dental, veterinary and diagnostic apparatus, devices and instruments; inhalation devices; inhalation devices for medical use; inhalers; metered dose inhalers; dry powder inhalers; aerosol inhalers; aqueous inhalers; nebulisers; ampoules, vials and containers for medical and pharmaceutical purposes; parts; components and fittings for all the aforesaid goods included in class 10.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations and substances for use in the treatment of respiratory conditions or ailments; pharmaceutical preparations and substances for use in the prevention or treatment of respiratory illnesses or respiratory disorders, including asthma; pharmaceutical preparations and substances for use in respiratory inhaler devices. Medical apparatus; inhaler devices; inhaler devices for medical use; metered dose inhalers, dry powder inhalers, aerosol inhalers and aqueous inhalers, all for use in the treatment of respiratory conditions or ailments; nebulisers; parts, components and fittings for the aforesaid goods.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations and substances; pharmaceutical preparations and substances for use in the prevention or treatment of respiratory illnesses or respiratory disorders, including asthma. Inhalation devices, inhaler, metered dose inhalers; parts, components and fittings for the aforesaid goods.
