Abstract

P. aeruginosaP. aeruginosa.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61P 31/04 - Antibacterial agents
• A61K 38/08 - Peptides having 5 to 11 amino acids

Abstract

The present invention relates to a method for preparing a peptide of following general formula (I). It also relates to specific peptides, which have been prepared by the method according to the invention, and key synthesis intermediates.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
• A61P 31/04 - Antibacterial agents

Abstract

The invention provides for novel peptide derivatives and compositions comprising the same. The invention further provides methods of treatment comprising administering novel peptide derivatives and/or compositions comprising the same.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The present invention relates to a process for the synthesis of 2,4-diamino-3(S)-hydroxycarboxylic acid derivatives from 5-hydroxyectoine.

IPC Classes  ?

• C07C 269/04 - Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
• C07C 227/04 - Formation of amino groups in compounds containing carboxyl groups
• C07C 227/16 - Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
• C07C 227/18 - Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
• C07D 263/06 - Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Abstract

The invention provides for novel peptide derivatives and compositions comprising the same. The invention further provides methods of treatment comprising administering novel peptide derivatives and/or compositions comprising the same. Disclosed is a compound A of formula (I): Ra-Xaai -Xaa2-Xaa3- Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9- Rb (I), for treating or preventing a bacterial infection in a subject.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids

Abstract

The invention provides for novel peptide derivatives and compositions comprising the same. The invention further provides methods of treatment comprising administering novel peptide derivatives and/or compositions comprising the same.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids

Abstract

The present invention relates to a process for the synthesis of 2,4-diamino-3(S)-hydroxycarboxylic acid derivatives from 5-hydroxyectoine.

IPC Classes  ?

• C07C 269/04 - Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
• C07C 227/04 - Formation of amino groups in compounds containing carboxyl groups
• C07D 263/06 - Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Abstract

The present invention relates to antibiotic compounds, methods for producing said compounds, pharmaceutical compositions comprising said compounds, and methods of treatment comprising administering said compounds and/or compositions comprising said compounds.

IPC Classes  ?

• C07K 7/00 - Peptides having 5 to 20 amino acids in a fully defined sequenceDerivatives thereof
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
• A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof

Abstract

Antibiotic compounds purified from Xenorhabdus cabanillasii strain CNCM I-4418 and methods for producing said compounds and pharmaceutical compositions comprising said compounds and a pharmaceutically acceptable carrier for use in the treatment of fungal disease. Xenorhabdus cabanillasii strain CNCM I-4418.

IPC Classes  ?

• C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
• A61P 31/04 - Antibacterial agents

Abstract

The invention relates to a method for identifying a secondary metabolite with antibiotic properties produced by a producing micro-organism, including culturing the producing micro-organism in the presence of an inductor micro-organism and detecting the production of at least one secondary metabolite with antibiotic properties.

IPC Classes  ?

• C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor