The present invention generally relates to the use of bispecific FVIII mimetic antibodies in treatment of haemophilia such as haemophilia A with or without inhibitors and in particular methods for the treatment of the disease such as once every second month dosage regimens and compositions for use in such methods.
The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment of
hematological conditions, pharmaceutical preparations for
the treatment of anemia, pharmaceutical preparations for the
treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment of
hematological conditions, pharmaceutical preparations for
the treatment of anemia, pharmaceutical preparations for the
treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of
hematological conditions, pharmaceutical preparation for the
treatment of anemia, pharmaceutical preparations for the
treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment of
hematological conditions, pharmaceutical preparations for
the treatment of anemia, pharmaceutical preparations for the
treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment of
hematological conditions, pharmaceutical preparations for
the treatment of anemia, pharmaceutical preparations for the
treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment of
hematological conditions, pharmaceutical preparations for
the treatment of anemia, pharmaceutical preparations for the
treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment of
hematological conditions, pharmaceutical preparations for
the treatment of anemia, pharmaceutical preparations for the
treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment of
hematological conditions, pharmaceutical preparations for
the treatment of anemia, pharmaceutical preparations for the
treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment of
hematological conditions, pharmaceutical preparations for
the treatment of anemia, pharmaceutical preparations for the
treatment of sickle cell disease.
C07D 207/08 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
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(1) Préparations pharmaceutiques pour le traitement d'affections hématologiques, préparations pharmaceutiques pour le traitement de l'anémie, préparations pharmaceutiques pour le traitement de la drépanocytose.
05 - Pharmaceutical, veterinary and sanitary products
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(1) Préparations pharmaceutiques pour le traitement d'affections hématologiques, préparations pharmaceutiques pour le traitement de l'anémie, préparations pharmaceutiques pour le traitement de la drépanocytose.
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(1) Préparations pharmaceutiques pour le traitement d'affections hématologiques, préparations pharmaceutiques pour le traitement de l'anémie, préparations pharmaceutiques pour le traitement de la drépanocytose.
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(1) Préparations pharmaceutiques pour le traitement d'affections hématologiques, préparations pharmaceutiques pour le traitement de l'anémie, préparations pharmaceutiques pour le traitement de la drépanocytose.
05 - Pharmaceutical, veterinary and sanitary products
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(1) Préparations pharmaceutiques pour le traitement d'affections hématologiques, préparations pharmaceutiques pour le traitement de l'anémie, préparations pharmaceutiques pour le traitement de la drépanocytose.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparations for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparations for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparations for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparations for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
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(1) Préparations pharmaceutiques pour le traitement d'affections hématologiques, préparations pharmaceutiques pour le traitement de l'anémie, préparations pharmaceutiques pour le traitement de la drépanocytose.
05 - Pharmaceutical, veterinary and sanitary products
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(1) Préparations pharmaceutiques pour le traitement d'affections hématologiques, préparations pharmaceutiques pour le traitement de l'anémie, préparations pharmaceutiques pour le traitement de la drépanocytose.
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(1) Préparations pharmaceutiques pour le traitement d'affections hématologiques, préparations pharmaceutiques pour le traitement de l'anémie, préparations pharmaceutiques pour le traitement de la drépanocytose.
05 - Pharmaceutical, veterinary and sanitary products
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(1) Préparations pharmaceutiques pour le traitement d'affections hématologiques, préparations pharmaceutiques pour le traitement de l'anémie, préparations pharmaceutiques pour le traitement de la drépanocytose.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparations for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparations for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparations for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparations for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparation for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparation for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparation for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease..
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparation for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparation for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease..
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparation for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease..
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparation for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparation for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease..
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparation for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease..
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of hematological conditions, pharmaceutical preparation for the treatment of anemia, pharmaceutical preparations for the treatment of sickle cell disease.
The present invention generally relates to the use of bispecific FVIII mimetic antibodies in treatment of haemophilia such as haemophilia A with or without inhibitors and in particular methods for the treatment of the disease such as dosage regimens and compositions for use in such methods.
The present invention generally relates to the use of bispecific FVIII mimetic antibodies in treatment of haemophilia such as haemophilia A with or without inhibitors and in particular methods for the treatment of the disease such as dosage regimens and compositions for use in such methods.
The present invention generally relates to the use of bispecific FVIII mimetic antibodies in treatment of haemophilia such as haemophilia A with or without inhibitors and in particular methods for the treatment of the disease such as dosage regimens and compositions for use in such methods.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
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Pharmaceutical preparations, namely, pre-filled syringes with haemostasis management preparations, for subcutaneous injections Medical apparatus and instruments, namely, syringes for subcutaneous injections, for haemostasis management
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
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Pharmaceutical preparations, namely, pre-filled syringes with haemostasis management preparations, for subcutaneous injections Medical apparatus and instruments, namely, syringes for subcutaneous injections, for haemostasis management
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Pharmaceutical preparations for treatment of kidney diseases and for treatment of liver diseases, pharmaceutical preparations for treatment of primary hyperoxaluria
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
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(1) Pharmaceutical preparations, namely, pre-filled syringes with haemostasis management preparations, for subcutaneous injections.
(2) Medical apparatus and instruments, namely, syringes for subcutaneous injections, for haemostasis management.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
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(1) Pharmaceutical preparations, namely, pre-filled syringes with haemostasis management preparations, for subcutaneous injections.
(2) Medical apparatus and instruments, namely, syringes for subcutaneous injections, for haemostasis management.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
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Pharmaceutical preparations, namely, pre-filled syringes
with haemostasis management preparations, for subcutaneous
injections. Medical apparatus and instruments, namely, syringes for
subcutaneous injections, for haemostasis management.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
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Pharmaceutical preparations, namely, pre-filled syringes
with haemostasis management preparations, for subcutaneous
injections. Medical apparatus and instruments, namely, syringes for
subcutaneous injections, for haemostasis management.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
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(1) Préparations pharmaceutiques, à savoir seringues pré-remplies de préparations pour la gestion de l'hémostase, pour injections sous-cutanées.
(2) Appareils et instruments médicaux, à savoir seringues pour injections sous-cutanées, pour la gestion de l'hémostase.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations, namely, pre-filled syringes with haemostasis management preparations, for subcutaneous injections Medical apparatus and instruments, namely, syringes for subcutaneous injections, for haemostasis management
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
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(1) Préparations pharmaceutiques, à savoir seringues pré-remplies de préparations pour la gestion de l'hémostase, pour injections sous-cutanées.
(2) Appareils et instruments médicaux, à savoir seringues pour injections sous-cutanées, pour la gestion de l'hémostase.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
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Pharmaceutical preparations, namely, pre-filled syringes with haemostasis management preparations, for subcutaneous injections Medical apparatus and instruments, namely, syringes for subcutaneous injections, for haemostasis management
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
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Pharmaceutical preparations, namely, subcutaneous syringes pre-filled with preparations for haemostasis management. Medical apparatus and instruments, namely subcutaneous syringes for haemostasis management.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
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Pharmaceutical preparations, namely, subcutaneous syringes pre-filled with preparations for haemostasis management. Medical apparatus and instruments, namely subcutaneous syringes for haemostasis management.
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Pharmaceutical preparations for the treatment of kidney
diseases and for the treatment of liver diseases,
pharmaceutical preparations for the treatment of primary
hyperoxaluria.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for treatment of kidney diseases
and for treatment of liver diseases, pharmaceutical
preparations for treatment of primary hyperoxaluria.
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10 - Medical apparatus and instruments
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(1) Pharmaceutical preparations, namely, hypodermic disposable syringes filled with preparations for the treatment of growth hormone deficiencies.
(2) Medical apparatus and instruments, namely hypodermic syringes.
09 - Scientific and electric apparatus and instruments
36 - Financial, insurance and real estate services
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
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Brochures, downloadable from the internet, in the field of sickle cell disease healthcare; downloadable support resources, namely, brochures, guides, checklists, and healthcare forms in the field of sickle cell disease healthcare; downloadable videos in the field of sickle cell disease healthcare Providing grants for sickle cell disease healthcare and research Education services, namely, providing resources in the field of sickle cell disease healthcare, namely, providing podcasts in the field of sickle cell disease healthcare, and online publications, namely, brochures and guides in the field of sickle cell disease healthcare, and providing a website featuring online videos, non-downloadable, in the field of sickle cell disease healthcare Providing online educational information in the field of sickle cell disease healthcare; providing an interactive website featuring information and links to websites of others featuring treatment information in the field of sickle cell disease healthcare
09 - Scientific and electric apparatus and instruments
36 - Financial, insurance and real estate services
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Brochures, downloadable from the internet, in the field of sickle cell disease healthcare; downloadable support resources, namely, brochures, guides, checklists, and healthcare forms in the field of sickle cell disease healthcare; downloadable videos in the field of sickle cell disease healthcare Providing grants for sickle cell disease healthcare and research Education services, namely, providing resources in the field of sickle cell disease healthcare, namely, providing podcasts in the field of sickle cell disease healthcare, and online publications, namely, brochures and guides in the field of sickle cell disease healthcare, and providing a website featuring online videos, non-downloadable, in the field of sickle cell disease healthcare Providing online educational information in the field of sickle cell disease healthcare; providing an interactive website featuring information and links to websites of others featuring treatment information in the field of sickle cell disease healthcare, i
05 - Pharmaceutical, veterinary and sanitary products
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(1) Préparations pharmaceutiques pour le traitement des maladies rénales et pour le traitement des maladies du foie, préparations pharmaceutiques pour le traitement de l'hyperoxalurie primaire.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment of kidney diseases and for the treatment of liver diseases, pharmaceutical preparations for the treatment of primary hyperoxaluria
05 - Pharmaceutical, veterinary and sanitary products
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(1) Préparations pharmaceutiques pour le traitement des maladies rénales et pour le traitement des maladies du foie, préparations pharmaceutiques pour le traitement de l'hyperoxalurie primaire.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment kidney diseases and treatment of liver diseases, pharmaceutical preparations for the treatment of primary hyperoxaluria.
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment kidney diseases and treatment of liver diseases, pharmaceutical preparations for the treatment of primary hyperoxaluria.