Abstract

Disclosed are an imidazothiazole derivative, a preparation method therefor, and an application thereof. The imidazothiazole derivative has a structure represented by formula (I): R1 and R3 are each independently selected from optionally substituted five-membered to six-membered heterocyclyl containing one to two nitrogen atoms, and R2 and R4 are each independently selected from optionally substituted aryl or heteroaryl. The imidazothiazole derivative has good MNK inhibitory activity, excellent selectivity, and an excellent in vivo hypoglycemic effect, and has a wide medicinal background.

IPC Classes  ?

• C07D 513/04 - Ortho-condensed systems
• A61K 31/433 - Thiadiazoles
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

A DHA-lutein ester, and a preparation method therefor and a use thereof. The DHA-lutein ester is a lutein monoester and/or a lutein diester, and can be used in preparation of products capable of stable and efficient eye protection and vision improvement. By synthesizing DHA and lutein into a DHA-lutein ester, not only the stability and bioavailability of lutein are improved, but also the advantages of DHA and lutein are integrated, and DHA synergistically assists lutein in acting in the macula of the retina, thereby protecting eye health and improving vision. The DHA-lutein ester can be further prepared into an oil suspension and microcapsule powder for use in the fields of food additives, dietary supplements, pet food and the like, and has a good application prospect.

IPC Classes  ?

• C07C 403/24 - Derivatives of cyclohexane or of a cyclohexene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
• A23L 33/12 - Fatty acids or derivatives thereof
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A23L 2/52 - Adding ingredients
• A23C 9/152 - Milk preparationsMilk powder or milk powder preparations containing additives

Abstract

An in-situ electrolytic gas compression and power output system using static pressure of seawater; a deep-sea water electrolysis hydrogen production system includes multiple electrolytic tanks located in deep sea, an electrolytic power supply, an oxygen pressure stabilizing tank communicated with the electrolytic tanks through an oxygen transportation pipeline, and a hydrogen pressure stabilizing tank communicated with the electrolytic tanks through a hydrogen transportation pipeline; the oxygen pressure stabilizing tank is communicated with an oxygen pneumatic motor through a pipeline with a one-way valve; the hydrogen pressure stabilizing tank is communicated with a hydrogen pneumatic motor through a pipeline with a one-way valve to provide power output; hydrogen that has undergone work in the hydrogen pneumatic motor is transported to a sea surface hydrogen and oxygen collection relay ship through a hydrogen outlet pipeline for collection.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/70 - Assemblies comprising two or more cells
• C25B 15/02 - Process control or regulation

Abstract

A cable-connected separable marine geological environment investigation apparatus and an operating method therefor. Marine geological environment investigation and monitoring are integrated. Geological investigation is performed during the penetration of a CPT probe (12), and long-term monitoring on the marine geological environment can be performed by pressure sensors in a penetration rod (2) after the penetration of said CPT probe. By separating the penetration rod (2) and an apparatus body, after the penetration is completed, only the penetration rod (2) is left in the seabed. A cable is released by an underwater cable winch (48) during the separation of the penetration rod (2) and then returns onto a deck along with the apparatus body. Real-time power supply and data communication are performed by means of the deck. Long-term observation and real-time acquisition of measurement data can be implemented.

IPC Classes  ?

• G01C 13/00 - Surveying specially adapted to open water, e.g. sea, lake, river or canal

Abstract

A nanobody targeting glutathione peroxidase 4 and the use thereof. The nanobody has an amino acid sequence shown as one of SEQ ID NO. 1 to SEQ ID NO. 4 and SEQ ID NO. 9 to SEQ ID NO. 14. The nanobody has high specificity, high-temperature resistance and acid and base resistance, is easy to store, has low production cost and involves a short production cycle. The nanobody can be used as a specific detection reagent for glutathione peroxidase 4 and can successfully induce ferroptosis of tumor cells by means of targeting glutathione peroxidase 4, thus having good application prospects and wide development potentials.

IPC Classes  ?

• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
• C12N 15/13 - Immunoglobulins
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents

Abstract

A compound targeting HDAC and NAD synthesis and a pharmaceutically acceptable salt, hydrate, deuterate, isomer or prodrug thereof, as well as preparation and application thereof. Specifically, a compound shown in structural general formula (I) and a pharmaceutically acceptable salt, hydrate, deuterate, isomer or prodrug thereof are provided. The compound of the structural general formula (I) is a multi-target inhibitor, targeting HDAC and NAD targets, and exhibiting significant HDAC inhibitory activity, while representative compounds exhibit certain NAD inhibitory activity. A compound targeting HDAC and NAD synthesis and a pharmaceutically acceptable salt, hydrate, deuterate, isomer or prodrug thereof, as well as preparation and application thereof. Specifically, a compound shown in structural general formula (I) and a pharmaceutically acceptable salt, hydrate, deuterate, isomer or prodrug thereof are provided. The compound of the structural general formula (I) is a multi-target inhibitor, targeting HDAC and NAD targets, and exhibiting significant HDAC inhibitory activity, while representative compounds exhibit certain NAD inhibitory activity. Ring E-B-L-C (O)—(NH)r-R   (General formula I)

IPC Classes  ?

• C07D 491/048 - Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
• A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4355 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
• A61K 31/4365 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/4406 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/655 - Azo (—N=N—), diazo (=N2), azoxy (N—O—N or N(=O)—N), azido (—N3) or diazoamino (—N=N—N) compounds
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia
• C07C 247/12 - Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
• C07D 209/42 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 213/40 - Acylated substituent nitrogen atom
• C07D 213/56 - Amides
• C07D 307/85 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
• C07D 333/70 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 471/04 - Ortho-condensed systems
• C07D 495/04 - Ortho-condensed systems

Abstract

Disclosed are an aerogel with a hierarchical pore structure formed using a pulsed laser technology, and a preparation method and use thereof. In the preparation method, a nano silicon-containing inorganic material as a freezing element, a biomass polymer as a cross-linking agent, and deionized water as a solvent are mixed and a resulting mixture is left to stand and gelatinized to obtain a hydrogel; the hydrogel is frozen to form ice crystals therein, and the ice crystals are removed by freeze-drying to obtain a micron-nano porous aerogel; the micron-nano porous aerogel is subjected to customized millimeter-scale punching using a pulsed laser to obtain an aerogel with a millimeter-micron-nano hierarchical pore structure.

IPC Classes  ?

• C08J 9/28 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
• B23K 26/0622 - Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam by shaping pulses
• B23K 26/382 - Removing material by boring or cutting by boring
• B23K 26/402 - Removing material taking account of the properties of the material involved involving non-metallic material, e.g. isolators
• C02F 1/14 - Treatment of water, waste water, or sewage by heating by distillation or evaporation using solar energy
• C08J 3/075 - Macromolecular gels
• C08J 3/21 - Compounding polymers with additives, e.g. colouring in the presence of a liquid phase the polymer being premixed with a liquid phase
• C08J 9/36 - After-treatment
• C08K 3/34 - Silicon-containing compounds
• C08L 5/12 - Agar-agarDerivatives thereof
• F24S 70/16 - Details of absorbing elements characterised by the absorbing material made of ceramicDetails of absorbing elements characterised by the absorbing material made of concreteDetails of absorbing elements characterised by the absorbing material made of natural stone
• C02F 103/08 - Seawater, e.g. for desalination

Abstract

Embodiments of the present disclosure provide an injectable photothermal hydrogel based on melanin and a preparation method and an application thereof. The injectable photothermal hydrogel is a hydroxypropyl chitosan/bis-amino polyethylene glycol modified melanin nanoparticles (HPCS/MP) hydrogel. The HPCS/MP hydrogel is prepared by mixing bis-amino polyethylene glycol modified melanin nanoparticles (MP) with hydroxypropyl chitosan (HPCS). The MP is synthesized by an amidation reaction of the melanin and the bis-amino PEG. A ratio of a volume of an MP solution to a volume of an HPCS solution in the HPCS/MP hydrogel is 4:6. A concentration of the MP solution is 20 wt %. A concentration of the HPCS solution is 4 wt %.

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Abstract

Staphylococcus aureus and enhance the phagocytic ability of fish macrophages.

IPC Classes  ?

• A61P 37/04 - Immunostimulants
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 31/04 - Antibacterial agents
• C07K 14/46 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates

Abstract

MILK-DERIVED EXTRACELLULAR VESICLES FOR GUT BARRIER PROTECTION AND THERAPEUTIC APPLICATIONS IN GUT BARRIER ASSOCIATED LIVER METABOLIC DISEASES AND USES THEREOF Disclosed is a method of treating or preventing an intestinal hyperpermeability-associated liver metabolic disease in a subject in need thereof, the method comprising administering milk derived extracellular vesicles (mEVs) to the subject, to thereby protect intestinal barrier integrity. Also disclosed is a method of obtaining and purifying said mEVs.

IPC Classes  ?

• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention belongs to the technical field of coastal and marine engineering. Disclosed is a regional estimation method for marine environment dynamic elements. The method comprises the following steps: acquiring n-year timing sequence historical data of marine environment dynamic elements; according to weather system groups, extracting independent and co-distributed extreme samples; in a region where extreme sample information is sufficient, calculating a respective probability distribution parameter for a single point; on the basis of an artificial neural network, establishing a spatial evolution model of the parameters with longitudes, latitudes and water depths; on the basis of the established model, correcting a probability distribution parameter for a single point in a region with sufficient extreme samples; extrapolating the spatial model to a region where the extreme sample information is insufficient; and calculating a confidence interval of regional model estimation values in different recurrence periods by means of a region re-simulation method. The method mainly solves the problem of the uncertainty of design standard estimation values in different recurrence periods of marine and coastal structures being relatively large due to the fact that sample historical data of marine environment dynamic elements at some sea area positions is rare.

IPC Classes  ?

• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model

Abstract

A method including contacting a target molecule in a sample with a probe, the probe containing a target molecule binding domain capable of specifically binding to the target molecule and at least one reaction blocking modification, carrying out a first processing on a first region of the sample to cause the probe in the first region to be attached to a first tag sequence, carrying out a second processing on a second region that is different from the first region in the sample to cause the probe in the second region to be attached to a second tag sequence, the second tag sequence being different from the first tag sequence, and determining a composition of the probe attached to the first tag sequence and the probe attached to the second tag sequence.

IPC Classes  ?

• C12Q 1/6841 - In situ hybridisation
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

The present invention provides a selection method of array length of observation system, comprising: step S101: obtaining a seismic response equation for any point on ground based on wavefield propagation theory; step S102: determining at least one selection criterion of an optimum array length considering different factors according to the seismic response equation; step S103: obtaining the array lengths considering the different factors respectively according to the at least one selection criterion of the optimum array length; and step S104: integrating the array lengths considering the different factors and determining that the optimum array length is √{square root over (2)} times the depth of the destination layer. Compared with conventional array length calculation method the demonstration method of array length as proposed in the present invention has the advantages of higher accuracy and applicability for destination layers. It also has important significance in high resolution, high signal-to-noise ratio three-dimensional marine seismic explorations.

IPC Classes  ?

• G01V 1/28 - Processing seismic data, e.g. for interpretation or for event detection
• G01V 1/137 - Generating seismic energy using fluidic driving means, e.g. using highly pressurised fluids which fluids escape from the generator in a pulsating manner, e.g. for generating bursts
• G01V 1/38 - SeismologySeismic or acoustic prospecting or detecting specially adapted for water-covered areas

Abstract

The present disclosure discloses λ-carrageenase mutant OUC-CglA-DPQQ, which has an amino acid sequence as set forth in SEQ ID NO. 1 and an encoding gene as set forth in SEQ ID NO. 2. The λ-carrageenase mutant OUC-CglA-DPQQ is applied to degradation of carrageenan/preparation of λ-carrageenan oligosaccharides with high polymerization degree. The present disclosure further discloses a method for degrading carrageenan/preparing λ-carrageenan oligosaccharides with high polymerization degree by using the λ-carrageenase mutant OUC-CglA-DPQQ. The λ-carrageenase mutant OUC-CglA-DPQQ of the present disclosure can act on low viscosity carrageenan, and the polymerization degree of final product λ-carrageenan oligosaccharides is 10-20. The λ-carrageenase mutant of the present disclosure is excellent in enzymatic properties and specificity, and has important industrial application value and economic value in the preparation of λ-carrageenan oligosaccharides via an enzyme method.

IPC Classes  ?

• C12P 19/04 - Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
• C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)

Abstract

The present disclosure provides a biological control method for ciliate disease, and belongs to the technical field of biological control. The biological control method includes the following step: adding Chaenea vorax into an aquaculture pond to control the ciliate disease; and the Chaenea vorax includes Chaenea vorax PJ13002. According to the present disclosure, the Chaenea vorax PJ13002, a predatory protozoan, is introduced to recover a microbial food chain existing in nature in an aquaculture system and achieve biological control of the ciliate disease. Meanwhile, the Chaenea vorax PJ13002 can be directly ingested by aquaculture animals without causing diseases, so that a more stable aquaculture system can be formed, losses are avoided, costs are reduced, and economic benefits are increased. The method provides a new thought for controlling the ciliate disease and has an excellent popularization and application prospect.

IPC Classes  ?

• A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
• C12R 1/90 - Protozoa

Abstract

The present invention relates to a compound having a chemical formula (I), and further relates to a preparation method therefor and use thereof. Pharmacological experiment results show that the compound of the present invention has excellent anti-tumor activity, good stability, low toxicity, and broad-spectrum characteristics, can be used as an anti-tumor medicament, and provides a theoretical basis for subsequent research and development of patent medicine.

IPC Classes  ?

• C07C 233/49 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
• C07C 233/47 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
• C07C 233/18 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
• C07C 233/87 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
• C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
• A61K 31/235 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

It is provided a method and system for calculating a turbulent mixing intensity, a computer device and a storage medium. The method comprises: performing denoising preprocess on ocean spatiotemporal coupled shear profile data information obtained by a turbulence profiler; constructing a multi-layer turbulent mixing network with topological attributes, where the network includes nodes and connecting edges; and each node is formed by fusion of four physical properties: time series, scale data, energy local intermittency measure and phase; recognizing a cross-scale transfer process of the turbulent energy according to a presence state of the connecting edges in the network; and performing parametric calculation of the turbulent mixing intensity according to the topological attributes of the multi-layer turbulent mixing network. According to the method, quantitative calculation of a turbulent energy transport intensity in an observation area of a full ocean depth profile is implemented.

IPC Classes  ?

• G01C 13/00 - Surveying specially adapted to open water, e.g. sea, lake, river or canal

Abstract

Colpoda species JH2-5-4, with preservation number of China Center for Type Culture Collection (“CCTCC”) NO. C202229. A method of screening and selecting a highly efficient and active strain suitable for use as a microbial fertilizer in plant cultivation is provided. The selected ciliated protozoan strain shortens the germination time of plant seeds, promotes plant growth, and improves seedling survival rate.

IPC Classes  ?

• C05F 11/08 - Organic fertilisers containing added bacterial cultures, mycelia or the like
• A01G 7/06 - Treatment of growing trees or plants, e.g. for preventing decay of wood, for tingeing flowers or wood, for prolonging the life of plants
• C12N 1/10 - ProtozoaCulture media therefor
• C12R 1/90 - Protozoa

Abstract

Disclosed are a feedback data graph generation method and a refrigerator. The method comprises: traversing all original corpora in an original information library, and generating base directory data; extracting and forming entity information elements and entity relationship elements according to the base directory data; sequentially executing attribute merger and same-attribute segment aggregation according to the base directory data and the original information library to generate a plurality of groups of segment attribute elements corresponding to different text segment data; establishing entity nodes according to the entity information elements, establishing association relationships between entities according to the entity relationship elements, and correspondingly storing the segment attribute elements in the entity nodes according to the association relationships between the entities and the segments to generate a feedback data graph. The present method has high generation efficiency, better consistency, and higher granularity.

IPC Classes  ?

• G06F 16/36 - Creation of semantic tools, e.g. ontology or thesauri

Abstract

The present invention provides a characteristic SNP marker-based method for identifying litopenaeus vannamei breeds. On the basis of providing a characteristic SNP marker set of different litopenaeus vannamei breeds and populations, a method for identifying the genetic background and breed source of litopenaeus vannamei is established on the molecular level. The SNP site in the SNP marker set is position 36 in any of the sequences set forth in SEQ ID NOs: 1-14974.

IPC Classes  ?

• C12Q 1/6869 - Methods for sequencing
• G16B 20/30 - Detection of binding sites or motifs
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

Abstract

Disclosed is a method for determining 224Ra in a sediment by using a pulse ionization chamber emanometer, which belongs to the technical field of analysis and measurement. A pulse ionization chamber emanometer (PIC), a new emanometer, is used. Based on the half-life characteristics of different radon isotopes, one can separate the 220Rn activity from the total counts by dual counting. The resulting 220Rn measurement then can be used to determine the 224Ra activity in sediment according to the principle of secular radioactive equilibrium.

IPC Classes  ?

• G01T 1/185 - Measuring radiation intensity with ionisation-chamber arrangements
• G01T 1/167 - Measuring radioactive content of objects, e.g. contamination
• G01N 33/24 - Earth materials

Abstract

Provided is a hair-growth microneedle patch containing androgen receptor-proteolysis targeting chimeric molecules. The hair-growth microneedle patch comprises a sheet-like backing and a soluble microneedle body arranged on the sheet-like backing and containing androgen receptor-proteolysis targeting chimeric molecules. The soluble microneedle body comprises one or more of the androgen receptor-proteolysis targeting chimeric molecules, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a geometric isomer thereof, a tautomer thereof, an ester thereof, a prodrug thereof, a solvate thereof, a metabolite thereof, a nitrogen oxide thereof, or a deuterated compound thereof. Also provided are a preparation method for the hair-growth microneedle patch containing the androgen receptor-proteolysis targeting chimeric molecules and use thereof in the preparation of a drug for treating androgenetic alopecia. The patch has the advantages of being safe, efficient and convenient to use.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• A61K 47/66 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
• A61P 5/28 - Antiandrogens
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia

Abstract

A system for controlling the amount of a liquid carbon source released to a constructed wetland, includes: a carbon source pool, a carbon source pipe, a peristaltic pump, a programmable logic controller (PLC), a computer, a first flow meter, a first chemical oxygen demand (COD) sensor, a first total nitrogen (TN) sensor, a second TN sensor, a second COD sensor, an inlet pipe, and an outlet pipe. The first flow meter, the first COD sensor, and the TN sensor are disposed on the inlet pipe; the second COD sensor and the second TN sensor are disposed on the outlet pipe; the inlet pipe and the outlet pipe are connected to the constructed wetland; the carbon source pipe is connected to the carbon source pool via the peristaltic pump; the computer, the peristaltic pump, the first flow meter, and all sensors are connected to the PLC controller.

IPC Classes  ?

• C02F 3/32 - Biological treatment of water, waste water, or sewage characterised by the animals or plants used, e.g. algae

Abstract

An observation system arrangement length selection method, which comprises the following steps: step S101, acquiring a seismic response formula of any point on the earth's surface on the basis of a wave-field propagation theory; step S102, according to the seismic response formula, determining a selection criterion for the optimal arrangement length from different consideration factors; step S103, respectively obtaining arrangement lengths under different consideration factors by using the selection criterion for the optimal arrangement length; and step S104, integrating the arrangement lengths under different consideration factors, so as to determine the optimal arrangement length of an observation system. Compared with a conventional parameter demonstration method, a demonstration method for arrangement lengths has the advantages of being more accurate and more universal for a target layer, and has important significance for high-resolution and high signal-to-noise ratio three-dimensional seismic exploration in oceans and fields.

IPC Classes  ?

• G01V 1/06 - Ignition devices

Abstract

A marine controllable coded air gun seismic source and a design method therefor. The controllable coded air gun seismic source comprises an air gun array; the air gun array is formed by arranging and combining four air gun sub-arrays; the four air gun sub-arrays are respectively a sub-array 1, a sub-array 2, a sub-array 3, and a sub-array 4; the sub-array 1 is not subjected to delay excitation; the sub-array 2 and the sub-array 3 are subjected to delayed excitation for 24 ms; and the sub-array 4 is subjected to delayed excitation for 48 ms. According to the marine controllable coded air gun seismic source and the design method therefor, sea surface ghost reflection can be suppressed, both the low frequency and high frequency of a seismic source can be considered, and the quality of seismic acquisition data oriented to different levels of middle and deep layers can be guaranteed.

IPC Classes  ?

• G01V 1/04 - Generating seismic energy Details
• G01V 1/137 - Generating seismic energy using fluidic driving means, e.g. using highly pressurised fluids which fluids escape from the generator in a pulsating manner, e.g. for generating bursts

Abstract

A multi-object-oriented observation system and a design method therefor. The system comprises three continuous controllable coded seismic sources formed by sequentially delayed excitations. The continuous controllable coded seismic sources are combined with six streamers to form the observation system. Each continuous controllable coded seismic source consists of a controllable coded seismic source array constituted by four identical sub-arrays; and the excitation mode of the four identical sub-arrays is to excite according to a certain time delay. The array composition of seismic sources in a conventional observation system is same as that of the arrays of the continuously controllable coded seismic sources, but sub-arrays and seismic sources of the conventional observation system being excited at the same time. The present method has the advantages of low cost, high feasibility, high density and high coverage frequency.

IPC Classes  ?

• G01V 1/133 - Generating seismic energy using fluidic driving means, e.g. using highly pressurised fluids

Abstract

This invention discloses a model test device and method for curtain grouting and excavation of tunnels in high-temperature, water-rich and weak strata, comprising weak strata simulation system, working condition simulation system, curtain grouting system, and monitoring and data acquisition system. The weak strata simulation system is the main box used to fill the soft soil. The working condition simulation system includes a high geothermal simulation system, a water pressure simulation system with stepwise loading of water pressure and volume, and a three-dimensional confining pressure simulation system with stepwise controllable loading of confining pressure. The invention can realize the whole test process simulation of grouting reinforcement and excavation of tunnels in weak strata effectively under the action of confining pressure and geothermal heat, and it has a positive reference effect on actual soft stratum tunnel curtain grouting and safe excavation.

IPC Classes  ?

• G09B 25/00 - Models for purposes not provided for in group , e.g. full-sized devices for demonstration purposes

Abstract

This invention discloses a model test apparatus and method for shield post-wall grouting and tube sheet uplift under high water pressure conditions, comprising main body box, tension apparatus, shield system, grouting system, ground stress loading system, water injection system, and monitoring system. The main body box comprises the shield shell system and model soil inside. The ground stress loading system and water injection system realize the simulation of the complex underground soil and muddy water environment by applying stress and water pressure to the model soil inside the main box. While the tension apparatus makes the shield shell moving forward, the grouting system injects slurry into the gap between the shield shell and the tube sheet. The integrated model test of visual shield grouting and tube sheet uplift, the real-time multi-physical field responses, and the longitudinal deformation mechanism have been realized and revealed under high water pressure conditions.

IPC Classes  ?

• G01V 99/00 - Subject matter not provided for in other groups of this subclass

Abstract

An equipment and application method for sinkage detection and active escape of deep-sea mining vehicle, comprising: the sinkage detection and warning devices and the self-escape equipment. The sinkage detection and warning devices are installed on the left and right sides of each track of the deep-sea mining vehicle, and it monitors the contact conditions between the tracks and the sediment, and the distance from the bottom of the track to the device is measured. The self-escape equipment comprises the active interactive grouting system, which connects to intelligent steering and retractable grouting heads. The intelligent steering and retractable grouting heads are also located on the left and right sides of each track. This invention can detect the complex driving environment of the seafloor automatically and combine the existing grouting technology and materials to achieve active grouting escape in case of excessive sinkage.

IPC Classes  ?

• E21C 50/00 - Obtaining minerals from underwater, not otherwise provided for
• B63G 8/00 - Underwater vessels, e.g. submarines

Abstract

Provided is a use of an azaphilone compound of formula (I) in the preparation of drugs for treating or preventing diseases, including but not limited to tumors, autoimmune diseases, infectious diseases and aging, and a method for treating the diseases by using the compounds. The present invention further relates to a novel azaphilone compound as an NK activator.

IPC Classes  ?

• A61K 31/365 - Lactones
• A61K 31/4741 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
• C07D 493/04 - Ortho-condensed systems
• C07D 491/048 - Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
• C07D 311/76 - Benzo [c] pyrans
• A61P 35/00 - Antineoplastic agents

Abstract

An inter-multi-body multi-step motion compensation connection method for an offshore floating photovoltaic system. An offshore floating photovoltaic system (1) comprises floating body modules (10), which are configured to carry upper supports (18) of solar photovoltaic assemblies and configured to support lower floating bodies (22) of the upper supports (18). The connection method comprises the following steps: arranging at least one first motion compensation device (26, 28) at the connection portion of each upper support (18) and the corresponding lower floating body (22), the first motion compensation device (26, 28) being configured to absorb the impact of the environmental load at the connection portion of each upper support (18) and the corresponding lower floating body (22); and arranging at least one second motion compensation device (48) between the adjacent floating body modules (10), the second motion compensation device being configured to connect the adjacent floating body modules (10) and absorb the impact of the environmental load acting between the adjacent floating body modules (10). The multi-body multi-step motion compensation connection method improves the system stability.

IPC Classes  ?

• B63B 35/44 - Floating buildings, stores, drilling platforms, or workshops, e.g. carrying water-oil separating devices
• F16F 15/02 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system
• F16F 15/04 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system using elastic means

Abstract

The present disclosure relates to a feed additive for improving intestinal structure of Larimichthys crocea, a feed and use, and belongs to the field of aquatic animal nutritional feeds. The feed additive includes glyceryl monolaurate. The present disclosure further provides a feed containing the feed additive, and a mass percentage of the glyceryl monolaurate in the feed is 0.04%. The present disclosure further provides use of the feed additive in improving the intestinal structure of the L. crocea, and the use lasts for at least 70 days. The feed provided by the present disclosure can effectively improve intestinal morphological change, reduced intestinal villi, reduced intestinal perimeter ratio, and intestinal barrier damage caused by replacement of fish oil with soybean oil; and damage of intestinal antioxidant activity caused by replacement of fish oil with soybean oil is relieved.

IPC Classes  ?

• A23K 20/158 - Fatty acidsFatsProducts containing oils or fats
• A23K 50/80 - Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs

Abstract

This invention discloses a double-liquid grouting slurry, its technology and application for super large diameter underwater shield engineering under high water pressure condition. The materials of slurry I are: 35-45 parts of cement clinker; 15-25 parts of slag; 24-35 parts of fly ash; 15-25 parts of steel slag; 5-15 parts of bentonite; 4-10 parts of limestone tailing; 0.3-2.0 parts of water reducing agent; 0.5-2.5 parts of cellulose. The materials of slurry II are: 0.2-3.8 parts of short-cut fiber; 96-99 parts of sodium silicate solution; 0.8-4.8 parts of viscous polymers. This invention generates the double-liquid slurry preparation process including crushing-screening-milling-group mixing-grouped mixing at different speeds, the volume ratio of slurry I and II is 1:1-10:1 during grouting, and the slurry is injected into the shield void through the six-point position technology at the shield tail and 3+2+1 segment splicing synchronous grouting techniques.

IPC Classes  ?

• C04B 28/26 - Silicates of the alkali metals
• C04B 14/10 - Clay
• C04B 14/28 - Carbonates of calcium
• C04B 14/46 - Rock wool
• C04B 16/06 - Macromolecular compounds fibrous
• C04B 24/38 - Polysaccharides or derivatives thereof
• C04B 24/26 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• E21D 11/10 - Lining with building materials with concrete cast in situShuttering or other equipment adapted therefor

Abstract

95 of the material particles as 35-40, 42-48 and 50-55 μm, respectively. Gold tailing with the particle size of 120-600 μm being used as the fine aggregate, their volume fractions are 40-60%. The slurry production technique, comprising crushing-sieving-superfine ball milling-homogenization-particle size classification-variable speed mixing being developed. The shield tail eight-point grouting technique is being developed for filling.

IPC Classes  ?

• C04B 28/00 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
• C04B 18/12 - Waste materialsRefuse from quarries, mining or the like
• C04B 18/14 - Waste materialsRefuse from metallurgical processes
• C04B 18/165 - Ceramic waste
• C04B 22/00 - Use of inorganic materials as active ingredients for mortars, concrete or artificial stone, e.g. accelerators
• C04B 22/08 - Acids or salts thereof
• C04B 24/04 - Carboxylic acidsSalts, anhydrides or esters thereof
• C04B 24/12 - Nitrogen containing compounds
• C04B 28/14 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing calcium sulfate cements
• C04B 40/00 - Processes, in general, for influencing or modifying the properties of mortars, concrete or artificial stone compositions, e.g. their setting or hardening ability
• E21D 11/10 - Lining with building materials with concrete cast in situShuttering or other equipment adapted therefor
• C04B 111/00 - Function, property or use of the mortars, concrete or artificial stone
• C04B 111/70 - Grouts
• C04B 111/74 - Underwater applications

Abstract

An auto-collapsible pore pressure probe device, including a support system, a penetration system and a measurement system. The support system includes a first support frame, a second support frame, a separation mechanism, a ring clamp, a fixing nut, a fixing bolt, support legs, slots, a support base, and a third support frame. The penetration system includes a rod storage wheel, a motor, a tightening mechanism, a penetration drive motor, a gear, a fixing bracket, a fixing bolt, and a friction wheel. The measurement system includes a pore pressure probe, a control cabinet, a CPTU probe, a pore pressure sensor, a probe connector, an external thread, an internal thread, a fastening strip, a connecting bolt, a connector, a data transmission and power supply cable, a displacement sensor, and a deck unit. An operating method of the pore pressure probe device is also provided.

IPC Classes  ?

• E21B 49/00 - Testing the nature of borehole wallsFormation testingMethods or apparatus for obtaining samples of soil or well fluids, specially adapted to earth drilling or wells

Abstract

A method for preparing double-stranded RNA, mainly solving the problem that existing double-stranded RNA preparation methods have complicated steps, low efficiency and high cost and are unlikely to achieve preparation in large amount. For double-stranded RNA to be prepared, a circular double-stranded DNA template containing a bubble structure having a length of 5-15 bp and having no promoter is first designed; then the circular double-stranded DNA template having no promoter, RNA polymerase, ribonuclease H, an RNase inhibitor, NTPs, and inorganic pyrophosphatase are added simultaneously into a system for transcription, during the transcription process, efficient bidirectional rolling circle transcription without preference is performed by RNA polymerase, and with the assistance of single-stranded DNA at the bubble structure in the circular double-stranded DNA template, restriction enzyme cutting of a transcription product containing a repeated sequence is achieved by ribonuclease H, so as to obtain a double-stranded RNA monomer that satisfies requirements. According to the method, double-stranded RNA is prepared in one step, efficiently and in large amount.

IPC Classes  ?

• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• C12Q 1/6844 - Nucleic acid amplification reactions

Abstract

Provided is the use of an Sbp9 protein or a homologous protein thereof in the preparation of a cell-matrix-like biomaterial, wherein the Sbp9 protein or the homologous protein thereof are used together with Ca2+. The cell-matrix-like biomaterial has waterproof and high adhesion properties, can promote cell growth, promote wound healing and prevent oxidative damage, and combines material adhesion with biological activity.

IPC Classes  ?

• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C09D 189/00 - Coating compositions based on proteinsCoating compositions based on derivatives thereof
• A61L 24/10 - PolypeptidesProteins
• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
• C12N 15/12 - Genes encoding animal proteins
• C12N 15/64 - General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host

Abstract

13244 are each independently selected from optionally substituted aryl or heteroaryl. The imidazothiazole derivative has good MNK inhibitory activity, excellent selectivity, and an excellent in vivo hypoglycemic effect, and has a wide medicinal background.

IPC Classes  ?

• C07D 513/04 - Ortho-condensed systems
• A61K 31/429 - Thiazoles condensed with heterocyclic ring systems
• A61K 31/433 - Thiadiazoles
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/06 - Antihyperlipidemics
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 35/00 - Antineoplastic agents

Abstract

A method for predicting heaving motion parameters of a semi-submersible offshore platform based on heaving acceleration includes: in heaving motion of a semi-submersible offshore platform, representing heaving acceleration of the semi-submersible offshore platform based on a linear potential flow theory; considering a noise influence of a heaving motion measurement marine environment, a low-frequency influence caused by a slow change of the environment and an influence caused by a baseline drift error of an acceleration sensor, introducing a noise term, a low-frequency change term and a baseline drift error term, and uniformly representing the noise term, the low-frequency change term and the baseline drift error term by a unified Prony sequence; and removing a drift term from uniformly represented heaving acceleration, establishing a relationship between the heaving acceleration and heaving motion parameters in terms of the remaining Prony sequence with the drift term being removed, and estimating the heaving motion parameters.

IPC Classes  ?

• B63B 79/20 - Monitoring properties or operating parameters of vessels in operation using models or simulation, e.g. statistical models or stochastic models
• B63B 79/10 - Monitoring properties or operating parameters of vessels in operation using sensors, e.g. pressure sensors, strain gauges or accelerometers

Abstract

An optimal design analysis method for a crane ship based on multi-body motion and dynamic coupling, comprising: performing modeling of a rigid body and a flexible body of a crane ship; connecting the rigid body and the flexible body; establishing a virtual prototype of the crane ship; simulating a lifting state; calculating the height of the center of gravity and the radius of gyration according to a set loading solution; setting operating conditions and performing hydrodynamic calculations to determine a time step and a simulation cycle; selecting a motion response of a degree of freedom of a hull and importing same into ADAMS for driving simulation, and outputting, in a set period of time, time-history change curves of tension values of first, second, and third control luffing ropes and a hoisting rope, and a stress value at a node corresponding to the maximum stress of a rotary platform support; and comparing the time-history change curves in a resting state and a motion state, and establishing, when the hull is in the resting state and motion state, a dynamic coupling amplification relationship of the tension values of the first, second, and third control luffing ropes and the hoisting rope, and the stress value at the node corresponding to the maximum stress of the rotary platform support. Thus, the simulation efficiency may be improved, and real response features may be captured, providing effective suggestions and guidance for actual operations.

IPC Classes  ?

• G06F 30/23 - Design optimisation, verification or simulation using finite element methods [FEM] or finite difference methods [FDM]
• G06F 111/04 - Constraint-based CAD
• G06F 119/14 - Force analysis or force optimisation, e.g. static or dynamic forces
• G06F 30/15 - Vehicle, aircraft or watercraft design

Abstract

The present invention provides a hole pressure probe rod apparatus that can fold automatically, comprising a support system, a penetrating system, and a measurement system. Directed towards certain problems in the current research and development of seabed pore water pressure monitoring apparatus under extreme storm conditions, a set of hole pressure probe rod apparatus that can fold automatically is designed. The described apparatus has a simple structure, a large penetration depth, a small size, and other characteristics, and can perform long-term in-situ stable monitoring on the pore water pressure at the interior of a seabed soil layer in the range of 0-5 m. By means of the technical solution of the present invention, the difficulty of monitoring the pore water pressure of a vertical section of the seabed is solved. The problem that the overall device is huge and stability is low due to a pore water pressure probe rod being overly long is solved. The problem that an observation apparatus is difficult to recover due to burying is solved.

IPC Classes  ?

• G01L 11/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by means not provided for in group or

Abstract

An acoustic monitoring system and method for the health status of an offshore wind turbine and an ocean wave are provided. The acoustic monitoring system includes a first laser transmitter, a second laser transmitter, a telephoto camera provided at a hub, a vibration detection sensor provided on a tower of a wind turbine, and four acoustic detection sensors arranged at an interval of 90° along the circumference of the tower. The first and second laser transmitters are arranged at the bottom of a nacelle of the wind turbine and emit laser lights vertically downward. The first laser transmitter, the second laser transmitter, the telephoto camera, the vibration detection sensor, and the acoustic detection sensors are connected to a data acquisition and conversion module through a transmission module. The acoustic monitoring system combines laser light detection with acoustic signal feature detection to improve stability and safety of the offshore wind turbine.

IPC Classes  ?

• F03D 17/00 - Monitoring or testing of wind motors, e.g. diagnostics

Abstract

The present invention relates to a biological polysaccharide hydrogel, a preparation method therefor and an application thereof. The biological polysaccharide hydrogel of the present invention is formed by means of the mixing and reaction of two solutions; the first solution is a polysaccharide derivative solution having an aldehyde on a side chain; the second solution is a polysaccharide derivative solution having a primary amine on a main chain or a side chain, or a small molecule compound solution having two or more primary amines. The preparation method of the present invention comprises preparing the first solution and the second solution, and then mixing the first solution and the second solution to form a transparent biological polysaccharide hydrogel. The biological polysaccharide hydrogel of the present invention can be applied as a vitreous substitute.

IPC Classes  ?

• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/58 - Materials at least partially resorbable by the body
• A61L 27/50 - Materials characterised by their function or physical properties
• A61L 27/26 - Mixtures of macromolecular materials
• A61L 27/20 - Polysaccharides

Abstract

The present disclosure discloses a degassing-free underwater dissolved carbon dioxide detection device and a detection method. The degassing-free underwater dissolved carbon dioxide detection device includes a computer, which is used to provide the driving signal and controlling parameters for the power tuning unit; the computer is connected with a laser driving control module and the power tuning unit, respectively; the laser driving control module is connected with a laser; the laser is connected with a photo-isolator; the photo-isolator is connected with a thulium-doped fiber vertical-cavity laser system; the thulium-doped fiber vertical-cavity laser system is connected with a photoacoustic cell system through a fiber collimator; the photoacoustic cell system is connected with a pre-amplifier circuit and a lock-in amplifier in sequence, and the lock-in amplifier is connected with the computer.

IPC Classes  ?

• H01S 3/13 - Stabilisation of laser output parameters, e.g. frequency or amplitude
• G01N 15/06 - Investigating concentration of particle suspensions
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• H01S 3/067 - Fibre lasers
• H01S 3/094 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light
• H01S 3/11 - Mode lockingQ-switchingOther giant-pulse techniques, e.g. cavity dumping
• H01S 3/16 - Solid materials

Abstract

The present disclosure provides a shield sealing device and a shield sealing method, a pile wall is arranged at a shield receiving opening, the shield sealing device is mounted on the pile wall, and the shield sealing device comprises: an elastic inner ring, an inner wall of the elastic inner ring adapting to an outer wall of a cutter head of a shield tunneling machine; and a plurality of control units, the plurality of control units being mounted on the pile wall, the plurality of control units being arranged in a circumferential direction of the elastic inner ring at intervals, and a driving end of the control part pressing against an outer side of the elastic inner ring so as to extrude or release the elastic inner ring.

IPC Classes  ?

• E21D 9/14 - Layout of tunnels or galleriesConstructional features of tunnels or galleries, not otherwise provided for, e.g. portals, day-light attenuation at tunnel openings
• E21D 9/06 - Making by using a driving shield

Abstract

The present invention provides a compound targeting HDAC and NAD synthesis and a pharmaceutically acceptable salt, hydrate, deuterated substance, isomer, or prodrug of the compound, and preparation and application thereof. Specifically, provided are a compound represented by structural general formula (I) and a pharmaceutically acceptable salt, hydrate, deuterated substance, isomer, or prodrug of the compound. The compound of structural general formula (I) is a multi-target inhibitor, which targets HDAC and NAD targets and exhibits significant HDAC inhibitory activity; moreover, a representative compound exhibits certain activity for inhibiting NAD. Ring E-B-L-C(O)-(NH)r-R (general formula I)

IPC Classes  ?

• C07D 213/56 - Amides
• C07D 209/14 - Radicals substituted by nitrogen atoms, not forming part of a nitro radical
• C07D 335/06 - BenzothiopyransHydrogenated benzothiopyrans
• A61K 31/4406 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

The present disclosure belongs to the field of petroleum engineering, and specifically relates to a subsea Christmas tree re-prediction method integrating Kalman filter and Bayesian network. The subsea Christmas tree re-prediction method integrating Kalman filter and Bayesian network includes three steps: digital twin model establishment, degradation process re-prediction model establishment, and remaining useful life calculation model establishment. The subsea Christmas tree re-prediction system integrating Kalman filter and Bayesian network includes a subsea distribution unit information acquisition subsystem mounted on an subsea distribution unit, a subsea control module information acquisition subsystem mounted on a subsea control module, a subsea valve bank information acquisition subsystem mounted on a subsea valve bank, a wellhead mechanical module information acquisition subsystem mounted on a wellhead mechanical module, a subsea environmental information acquisition module mounted on a subsea control module, and a subsea Christmas tree digital twin subsystem mounted in an overwater control station.

IPC Classes  ?

• G06F 30/17 - Mechanical parametric or variational design
• E21B 33/035 - Well headsSetting-up thereof specially adapted for underwater installations
• G06F 17/16 - Matrix or vector computation
• G06F 111/08 - Probabilistic or stochastic CAD

Abstract

A drug molecule intelligent generation method based on reinforcement learning and docking, belonging to the technical field of drug chemistry and computers. The method comprises the following steps: 1) constructing a virtual fragment combination library for drug design; 2) calculating fragment similarity, and performing molecular fragment coding; and 3) generating and optimizing a molecule on the basis of an actor-critic model for reinforcement learning. In the described method, on the basis of a lead compound, the chemical space of a search is reduced. Transformer modeling is used by means of an actor-critic model for reinforcement learning, position information of a molecular fragment is introduced, and relative or absolute position information of the fragment in a molecule is stored, thereby achieving parallel training. Furthermore, by means of establishing a single-layer perceptron model, a reward mechanism further optimizes the activity of a generated molecule.

IPC Classes  ?

• G16C 20/50 - Molecular design, e.g. of drugs

Abstract

A wave power generation unit and a wave power generation device comprising same, and a wave power generation method of the wave power generation device. The wave power generation unit comprises several individual back bent duct structures, which are connected in parallel. Each individual back bent duct structure comprises a bent duct and a buoy (3), wherein the bent duct comprises a vertical bent duct section (2) and a horizontal bent duct section (1), the upper portion of the horizontal bent duct section (1) being connected to the buoy (3), and adjacent vertical bent duct sections (2) being in communication with each other. The vertical bent duct section (2) of one individual back bent duct structure is connected to an air chamber pipeline (4), and the air chamber pipeline (4) is internally provided with an air turbine. The several individual back bent duct structures are combined and connected, and adjacent vertical bent duct sections (2) are in communication with each other, so as to do work on the same air turbine, such that the flow of a reciprocating air flow in an air chamber can be increased. The concept of forming resonance to improve the utilization efficiency of wave energy is provided, and the maximum wave height of water surface motion in an air chamber can be obtained in the parameter optimization process of the wave power generation device.

IPC Classes  ?

• F03B 13/24 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using wave energy to produce a flow of air, e.g. to drive an air turbine

Abstract

Disclosed is an auto-induction regulatory system based on quorum sensing, comprising luxI, luxR and egfp, wherein, the promoter for controlling the expression of luxI and luxR is selected from PluxI, PBB or PJ23100; the promoter for controlling the expression of egfp is selected from PluxI, PluxI(T-38C) or PluxI(C-77T). Also disclosed are an application of the auto-induction regulatory system based on quorum sensing in the automatic regulation of expression of a target gene of engineered Escherichia coli, as well as an application thereof in the preparation of alginate lyase and esterase. Further disclosed are a recombinant expression vector and a recombinant engineered bacterium comprising the auto-induction regulatory system based on quorum sensing.

IPC Classes  ?

• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 9/88 - Lyases (4.)
• C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans

Abstract

The present application relates to a product and method for analyzing the omics information of a sample. The method comprises: under the condition of binding a probe to a target molecule, contacting at least one target molecule in a sample with at least one probe, the probe containing a target molecule binding domain capable of specifically binding to the target molecule and at least one reaction blocking modification; carrying out a first processing on a first area of the sample and carrying out a second processing on a second area that is different from the first area in the sample to cause the probe in the first area to be attached to a first tag sequence and the probe in the second area to be attached to a second tag sequence, the second tag sequence being different from the first tag sequence; and determining the composition of the probe attached to the first tag sequence and the composition of the probe attached to the second tag sequence.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Abstract

The present application relates to a product and method for analyzing the omics information of a sample. The method comprises: under the condition of binding a probe to a target molecule, contacting at least one target molecule in a sample with at least one probe, the probe containing a target molecule binding domain capable of specifically binding to the target molecule and at least one reaction blocking modification; carrying out a first processing on a first area of the sample and carrying out a second processing on a second area that is different from the first region in the sample to cause the probe in the first area to be attached to a first tag sequence and the probe in the second area to be attached to a second tag sequence, the second tag sequence being different from the first tag sequence; and determining the composition of the probe attached to the first tag sequence and the composition of the probe attached to the second tag sequence.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Abstract

An allocation and stowage control method for a multifunctional full-rotation crane ship, comprising: obtaining an equilibrium equation, using the largest initial stability height as a target, obtaining a hoisting preparation stage model, and obtaining an optimal solution by using a single-target genetic algorithm; using the smallest maximum value of the allocation quantity of each ballast tank, the smallest trim angle of a crane ship when in a balanced state and the smallest heel angle of the crane ship when in the balanced state as targets, and obtaining a heavy object hoisting stage mathematical model; using the smallest maximum value of the allocation amount of each ballast tank, the smallest maximum value of the trim angle of the crane ship in a rotation process and the smallest maximum value of the heel angle of the crane ship in the rotation process as targets, and obtaining a hoisting rotation stage mathematical model; obtaining a optimal solution set by using a multi-target genetic algorithm, ranking optimal solutions by using an entropy weight-based TOPSIS method, and setting the highest ranked optimal solution as a target allocation and stowage solution of a heavy object hoisting stage/rotation stage; and controlling the crane ship to operate according to the target allocation and stowage solution. In addition, also disclosed are a multifunctional full-rotation crane ship, which executes the described allocation and stowage control method. The described method may improve allocation and stowage efficiency and accuracy.

IPC Classes  ?

• G06F 30/15 - Vehicle, aircraft or watercraft design
• B63B 27/16 - Arrangement of ship-based loading or unloading equipment for cargo or passengers of lifts or hoists
• G06F 111/06 - Multi-objective optimisation, e.g. Pareto optimisation using simulated annealing [SA], ant colony algorithms or genetic algorithms [GA]

Abstract

122 are both selected from a linear alkyl group consisting of 1-5 carbon atoms, a cycloalkyl group or cycloalcoylmethyl group consisting of 3-6 carbon atoms, a C2-C6 saturated or unsaturated alkyl group, or a fluorine-containing alkyl group consisting of 1-5 carbon atoms, and X is selected from carbon or nitrogen. The present invention proves, by means of pharmacological experiments, that the novel benzotropone derivative has the effects of inhibiting phosphodiesterase PDES activity, TNF-α release, neutrophilia or eosinophilia, and also can protect nerve cells, myocardial cells and vascular endothelial cells, has good safety, and thus has an important development significance.

IPC Classes  ?

• C07D 213/82 - AmidesImides in position 3
• C07D 239/36 - One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
• A61P 25/16 - Anti-Parkinson drugs
• A61P 37/08 - Antiallergic agents
• A61K 31/4412 - Non-condensed pyridinesHydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring

Abstract

The present disclosure provides an in-situ observation system for a bottom boundary layer (BBL) over a shallow-water cohesive seabed and an arrangement method thereof. It establishes a low-cost and easy-operation hydraulic pile foundation system (2), which can ensure the piling depth to achieve the anti-settling and stability. The stainless-steel sticks are assembled freely to construct the interference-free observation unit (1). As the porous discs are used between the feet of the observation unit (1) and the top of the bottom piles, the observation system can be accurately fixed to the pile foundation. It is thus not limited by the self-weight and can integrate various instruments upon requirement. The components in this system can be easily obtained and conveniently maintained. The present disclosure has the advantages of low-cost and stability, can be widely used for long-term in-situ observation of the BBL.

IPC Classes  ?

• G01C 13/00 - Surveying specially adapted to open water, e.g. sea, lake, river or canal

Abstract

The present invention relates to the technical field of ocean observation devices, and in particular relates to a long-term vortex-following observation system for an ocean and a design method. The vortex-following observation system comprises an ocean surface floating ball (1), a plastic-coated steel cable (2), an upper damping block (3), a lifting platform (4), a lower damping block (5), a tensioning hammer (6), a mooring line (72), a telescopic cable (8) and a water sail (9) which are sequentially arranged from the ocean surface downwards. The design method comprises the steps of collecting global vortexes and background three-dimensional flow field datasets, performing vortex-flow consistency analysis and pattern statistics, determining the deployment depth of the water sail (9) in the vortex-following observation system, and designing the specific dimensions of the water sail (9). The vortex-following observation system can achieve synchronization with the vortex center at the maximum probability. Compared to conventional mobile devices such as Drifter which is only driven by surface flows, and Argo which does not have flow-following capabilities, the vortex observation system has the advantages of a long vortex-following duration and an excellent observation effect. Furthermore, from the perspectives of big data statistics and theoretical analysis, a methodology for an on-site observation system to achieve long-term vortex-following is provided, thereby providing the theoretical basis and foundation for the design of all vortex-following observation systems.

IPC Classes  ?

• G01C 13/00 - Surveying specially adapted to open water, e.g. sea, lake, river or canal

Abstract

Disclosed are a thiolated polysaccharide derivative hydrogel, a preparation method therefor, and an application thereof. The thiolated polysaccharide derivative hydrogel is a thiolated hyaluronic acid polysaccharide derivative hydrogel or a thiolated chitin/chitosan derivative hydrogel. The thiolated hyaluronic acid polysaccharide derivative hydrogel is a polysaccharide hydrogel formed of one or two of thiolated hyaluronic acid derivatives and an aqueous solvent, and the thiolated chitin/chitosan derivative hydrogel is a polysaccharide hydrogel formed of one or two of thiolated chitin/chitosan derivatives and an aqueous solvent. The thiolated polysaccharide derivative hydrogel of the present invention is suitable for being used as a vitreous body substitute, and as the vitreous body substitute, can improve a shock absorption function, and can maintain the shape of an eyeball and press a retina in situ due to a good self-healing function and resilience.

IPC Classes  ?

• C08J 3/075 - Macromolecular gels
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• A61L 27/20 - Polysaccharides
• A61L 27/50 - Materials characterised by their function or physical properties
• A61L 27/52 - Hydrogels or hydrocolloids

Abstract

Provided is a method for preparing water-soluble astaxanthin complex. The method includes mixing a raw material containing astaxanthin with a solution containing an organic acid and performing cell disruption and leaching and can enable natural astaxanthin to interact with components such as proteins, nucleic acids, or polysaccharides that naturally exist in the raw material, so as to directly prepare water-soluble astaxanthin complex without modifying astaxanthin. The method requires a natural source of astaxanthin, has low equipment requirements and production costs, is simple to operate, green and safe with no organic solvent residues, and easy to industrialize. Provided is a method for preparing water-soluble astaxanthin complex. The method includes mixing a raw material containing astaxanthin with a solution containing an organic acid and performing cell disruption and leaching and can enable natural astaxanthin to interact with components such as proteins, nucleic acids, or polysaccharides that naturally exist in the raw material, so as to directly prepare water-soluble astaxanthin complex without modifying astaxanthin. The method requires a natural source of astaxanthin, has low equipment requirements and production costs, is simple to operate, green and safe with no organic solvent residues, and easy to industrialize. The representative figure is FIG. 1.

IPC Classes  ?

• C07C 403/24 - Derivatives of cyclohexane or of a cyclohexene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
• B01D 21/26 - Separation of sediment aided by centrifugal force
• B01D 11/02 - Solvent extraction of solids
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present application relates to an ocean observation method and system based on accompanying flight of two satellites respectively carrying an interference imaging altimeter and a laser radar. The ocean observation method comprises: an observation step, which is configured to observe, in an operation orbit, an ocean phenomenon by means of a first satellite and a second satellite which perform accompanying flight in the same operation orbit, wherein the first satellite performs ocean surface height observation by means of carrying an interference imaging altimeter, and the second satellite performs atmosphere and ocean profile observation by means of carrying an ocean profile laser radar; and a data processing and transmission step, which is configured to receive, by means of the first satellite, atmosphere and ocean profile observation data sent by the second satellite, and send, to a ground station, the atmosphere and ocean profile observation data and ocean surface height observation data from the first satellite, and which is configured to process, by means of the ground station, the ocean surface height observation data and the atmosphere and ocean profile observation data, so as to obtain an observation result. By means of the present application, the problem of realizing, at a low cost and low risk, the wide-swath and sub-mesoscale observation of an ocean and the remote sensing detection of a near thermocline of the ocean is solved.

IPC Classes  ?

• G01S 17/95 - Lidar systems, specially adapted for specific applications for meteorological use
• G01S 17/90 - Lidar systems, specially adapted for specific applications for mapping or imaging using synthetic aperture techniques
• G01S 7/48 - Details of systems according to groups , , of systems according to group

Abstract

An unloading type sinking rescue device of a subsea mining vehicle and a use method thereof are provided. The unloading type sinking rescue device includes an assembly support, an unloading system, an ejection system and a control system. The assembly support is box-shaped, fixed to a subsea mining vehicle, and provided with a plurality of enclosed cavities. The unloading system includes a counterweight, a counterweight cable, a counterweight fixing bracket and a counterweight recovery cavity. The ejection system includes an anchor, an ejection cavity, an anchor cable, an anchor recovery shaft, a pulley, a spring and a boosting device. The control system controls the operation of the unloading system and the ejection system. The use method includes: (1) unloading; (2) ejection; (3) recovery of a part of counterweights; (4) recovery of the anchor; and (5) recovery of remaining counterweights.

IPC Classes  ?

• E21C 50/00 - Obtaining minerals from underwater, not otherwise provided for
• B63C 11/52 - Tools specially adapted for working underwater, not otherwise provided for
• B63B 21/50 - Anchoring arrangements for special vessels, e.g. for floating drilling platforms or dredgers
• B62D 55/065 - Multi-track vehicles, i.e. more than two tracks

Abstract

A grouting and pile forming device includes a compartment box and a double-spiral-tube structure. The double-spiral-tube structure includes an outer spiral tube and an inner spiral tube, which are nested and fixed together. A top part of the outer spiral tube and a top part of the inner spiral tube are hermetically connected. An inner space of the inner spiral tube forms a grouting cavity. A space between the outer spiral tube and the inner spiral tube forms a drainage and delivery cavity. A plurality of drainage and delivery holes are provided in a tube body of the outer spiral tube. A construction method for strengthening soft soil through the grouting and pile forming device includes the following steps: 1) operation preparation; 2) downward spiral penetration; 3) drainage consolidation; 4) chemical consolidation; 5) upward spiral lifting; and 6) repeated operation until all soil to be strengthened is treated.

IPC Classes  ?

• E02D 5/46 - Concrete or concrete-like piles cast in position making in situ by forcing bonding agents into gravel fillings or the soil
• E02D 3/12 - Consolidating by placing solidifying or pore-filling substances in the soil

Abstract

A load rejection type subsidence escape self-rescue device of a submarine mine truck and a method for using same. The device comprises a mounting support (1), a load rejection system, a casting system and a control system (5). The load rejection system comprises a counterweight (4), a counterweight cable (2), a counterweight fixing support (8), and a counterweight recovering cavity (9). The casting system comprises a casting anchor (10), a casting cavity (11), a casting anchor cable (12), a casting anchor recovery rotating shaft (14), a pulley (3), a spring (15), and a boosting device (16). The use method comprises the steps of load rejection, casting, recovering part of the counterweight, recovering the casting anchor, and recovering the rest counterweights. According to the device and the method, the problem of subsidence of the submarine mine truck can be solved by using buoyancy and the load rejection and ejection systems; and energy consumption can be reduced.

IPC Classes  ?

• B63B 43/08 - Improving safety of vessels, e.g. damage control, not otherwise provided for reducing risk of capsizing or sinking by improving stability by transfer of solid ballast
• B63B 21/22 - Handling or lashing anchors
• E21C 50/00 - Obtaining minerals from underwater, not otherwise provided for

Abstract

A heave acceleration-based method for predicting a heave motion parameter of a semi-submersible ocean platform. The method comprises: during heave motion, on the basis of a linear potential flow theory, ignoring the coupling influence of additional mass and radiation damping, and representing a heave acceleration; taking the actually measured noise influence of an ocean environment, the low-frequency influence caused by a slow environment change and the influence caused by a baseline drift error of an acceleration sensor itself into consideration, introducing a noise term, a low-frequency change term and a baseline drift error term, and performing unified Prony sequence normalization representation on the noise term, the low-frequency change term and the baseline drift error term; and performing drift term removal on the heave acceleration that has been subjected to normalization representation, and establishing a relational expression between the heave acceleration and a heave motion parameter by means of a remaining Prony sequence obtained after a drift term is removed, so as to estimate the heave motion parameter. Compared with a filter-based method, estimating a heave motion parameter by means of a Prony sequence has a higher calculation accuracy.

IPC Classes  ?

• B63B 79/20 - Monitoring properties or operating parameters of vessels in operation using models or simulation, e.g. statistical models or stochastic models
• B63B 79/00 - Monitoring properties or operating parameters of vessels in operation

Abstract

A device for monitoring deep-sea sediment environment in mining polymetallic nodules is provided. The monitoring system includes: acoustic Doppler flow profilers, a self-potential probe, a turbidity meter and an underwater camera. The invention can realize long-term in-situ observation of sediment disturbance, and can realize the mechanical recovery of probe rod-type equipment without large-scale mechanical devices, thereby reducing the overall weight of the recovery equipment and increasing the probability of successful equipment recovery. Compared with the existing long-term in-situ observation equipment on the seabed, it is more environmentally friendly, efficient, energy-saving and reliable.

IPC Classes  ?

• G01V 11/00 - Prospecting or detecting by methods combining techniques covered by two or more of main groups
• E21C 39/00 - Devices for testing in situ the hardness or other properties of minerals, e.g. for giving information as to the selection of suitable mining tools
• G01V 1/38 - SeismologySeismic or acoustic prospecting or detecting specially adapted for water-covered areas
• G01V 3/08 - Electric or magnetic prospecting or detectingMeasuring magnetic field characteristics of the earth, e.g. declination or deviation operating with magnetic or electric fields produced or modified by objects or geological structures or by detecting devices
• G01V 8/02 - Prospecting
• B63B 27/10 - Arrangement of ship-based loading or unloading equipment for cargo or passengers of cranes
• E21C 50/00 - Obtaining minerals from underwater, not otherwise provided for

Abstract

Provided is an α9α10 nicotinic acetylcholine receptor (nAChR) inhibitory peptide and a use thereof. On the basis of the mechanism of interaction between α-conotoxin and α9α10 nicotinic acetylcholine receptors, mutants having a plurality of α-conotoxin monomeric peptides are designed, and a monomeric peptide mutant GEX-2 having high inhibitory activity and a good analgesic effect is screened from among the mutants. Further, a series of derivatives of GEX-2 are obtained by mutating GEX-2 by means such as alanine scanning, aspartic acid scanning, arginine scanning, arginine-citrulline substitution and D-amino acid substitution. The described GEX-2 can improve the pain threshold of a CCI rat, and has a good analgesic effect. In comparison with GEX-2, the inhibitory activity of a portion of members in the GEX-2 series derivatives on α9α10 nAChR is higher. The described GEX-2 and the series derivatives thereof may be used as α9α10 nAChR inhibitors for analgesia, fighting tumors, treating nervous system diseases, etc.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 1/20 - Partition-, reverse-phase or hydrophobic interaction chromatography
• C12N 15/12 - Genes encoding animal proteins
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• A61K 38/08 - Peptides having 5 to 11 amino acids

Abstract

A novel PSL family prenyltransferase has relaxed substrate specificity, which can use a variety of cyclic dipeptides and prenyl donors as substrates to produce various terpenylated diketopiperazines. An amino acid sequence of the prenyltransferase is SEQ ID NO: 1. An application of the prenyltransferase is transferring different prenyl groups to Trp-containing cyclic dipeptides. The prenyltransferase catalyzes the formation of terpenylated diketopiperazines by assembling prenyl groups onto cyclic dipeptides, which provides a new strategy for drug development of diketopiperazines.

IPC Classes  ?

• C12N 9/10 - Transferases (2.)

Abstract

An enzyme with an acyl transfer function has an amino acid sequence identical to a SEQ ID NO:1, which is capable of acylation modification for macrolactins, filipins macrolides, chloramphenicol, and glycosylated piericidin A. An application of an acyltransferase of the present invention is to bind an acyl group of an acyl donor to macrolide compounds, chloramphenicol and glycosylated piericidins. The enzyme with the acyl transfer function can improve pharmacological activity of the macrolide compounds through acylation reaction of macrolactins, thereby improving bioavailability, enhancing efficacy, and reducing toxic as well as side effects, which provides a new strategy for the drug development of macrolide compounds.

IPC Classes  ?

• C12P 17/08 - Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
• C12N 9/10 - Transferases (2.)

Abstract

A double-helical pipe for reinforcing soft and weak soil bodies, a grouting and pile-forming device, and a construction method therefor. The double-helical pipe comprises an outer helical pipe (1) and an inner helical pipe (2); the outer helical pipe (1) and the inner helical pipe (2) are nested and fixed together, the top of the outer helical pipe (1) is connected to the top of the inner helical pipe (2) in a sealed manner, the inner space of the inner helical pipe (2) forms a grouting cavity (9), the space between the outer helical pipe (1) and the inner helical pipe (2) forms a water discharge and liquid delivery cavity (10), and the pipe body of the outer helical pipe (1) is provided with several water discharge and liquid delivery holes (11). The grouting and pile-forming device further comprises a cabin tank (4). A construction method of a grouting and pile-forming device for reinforcing soft and weak soil bodies, comprising the following steps: 1) operation preparation; 2) forward-direction helical downward penetration; 3) water discharge and consolidation; 4) chemical consolidation; 5) reverse-direction helical rising; and 6) repeating operations until all soil bodies to be reinforced are processed. The grouting and pile-forming device has an ingenious structure, is easy and flexible to operate, and has a wide application range and high reliability.

IPC Classes  ?

• E02D 15/04 - Placing concrete in mould-pipes, pile tubes, boreholes, or narrow shafts
• E02D 5/34 - Concrete or concrete-like piles cast in position

Abstract

An anchoring device for adapting to tide level for a wave energy power generation device comprises: a housing, wherein a central main shaft is provided at the center thereof, two ends of the central main shaft are respectively rigidly connected to a volute spring, and the interior of the housing is divided into several independent compartments, including a central compartment accommodating the central main shaft; a shaft lock and a central main gear capable of driving the central main shaft to rotate mounted on the central main shaft; and a plurality of hoisting wheel compartments arranged at equal intervals in a circumferential array around the central main shaft. A hoisting wheel is provided in each of the hoisting wheel compartments, and an anchor chain wound on the hoisting wheel protrudes out of the housing through an opening at the bottom of the hoisting wheel compartment.

IPC Classes  ?

• F03B 13/14 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using wave energy
• B63B 21/46 - Anchors with variable, e.g. sliding, connection to chain

Abstract

An apparatus for monitoring a deep-sea polymetallic nodule mining sediment environment, which belongs to the technical field of long-term in-situ monitoring of deep-sea surface-layer mineral mining sediment disturbance. The monitoring apparatus comprises a monitoring system, wherein the monitoring system is provided with Doppler current profilers (101, 1012), a spontaneous potential detection rod (104), a turbidimeter (102) and an underwater camera (103). Long-term in-situ monitoring of sediment disturbance can be realized, mechanical recovery of a feeler-lever-type device can be realized, no large mechanical apparatus is needed, the overall weight of a recovery device is reduced, and the probability of the successful recovery of the device is increased. Compared with an existing sea floor long-term in-situ monitoring device, the monitoring apparatus is more environmentally friendly, efficient, energy-saving and reliable.

IPC Classes  ?

• G01S 15/88 - Sonar systems specially adapted for specific applications
• G01C 13/00 - Surveying specially adapted to open water, e.g. sea, lake, river or canal

Abstract

A high-precision measurement device for plasma seismic source wavelets under a shallow water condition, comprising two submarine cables (1) and one vertical cable (2) which are connected to a digital packet (3), and a floating ball (4), and an underwater compass (5); the two submarine cables (1) are respectively arranged in the x direction and the y direction, the vertical cable (2) has a top end connected to the floating ball (4) and a bottom end connected to the digital packet (3), the vertical cable (2) is arranged in the z direction and has a length less than a water depth, and the underwater compass (5) is fixed on the vertical cable (2); the submarine cables (1) each are provided with a plurality of sensor groups at equal intervals, and each sensor group comprises a vibration sensor and a pressure sensor (302); and the vertical cable (2) is provided with a plurality of sensor groups at equal intervals, and each sensor group is formed by two pressure sensors (302) connected in parallel. The present invention achieves three-dimensional observation of plasma seismic source wavelets under a shallow water condition by using the submarine cables (1) and the vertical cable (2), improves the accuracy of measurement of seismic source wavelets under a shallow water condition, and can monitors a rule of change of seismic source wavelets in both a transverse direction and a longitudinal direction; and compared to a horizontal streamer, the vertical cable and the submarine cables greatly reduce noise disturbance.

IPC Classes  ?

• G01V 1/38 - SeismologySeismic or acoustic prospecting or detecting specially adapted for water-covered areas

Abstract

The present disclosure relates to the field of medicinal chemistry, and specifically to the use in the inhibition of tumor proliferation activity of ester derivatives of brefeldin A represented by Formula (I). The new compounds provided herein are prominent in the prevention or treatment of hyperproliferative diseases, including liver cancer, leukemia, breast cancer, colon adenocarcinoma, gastric cancer, lung cancer, Bart's esophageal cancer, cervical cancer, pancreatic cancer, endometrial cancer, bone cancer, lymphoma, kidney cancer, brain cancer, nerve cancer, nasopharyngeal cancer, oral cancer and colorectal cancer, and have the potential to be developed as novel antitumor agents.

IPC Classes  ?

• C07D 313/00 - Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
• A61P 35/00 - Antineoplastic agents

Abstract

A pulse current generator and a control method. The pulse current generator comprises a DC power supply (U), a relay (K), and a controller (S). The controller (S) and the relay (K) are electrically connected. The relay (K) is connected in series in a circuit in which the DC power supply (U) supplies power to a load (R). The controller (S) controls closing and opening of the relay (K) on the basis of preset pulse parameters, thereby generating a pulse current to drive the load (R).

IPC Classes  ?

• H03K 17/04 - Modifications for accelerating switching
• C11B 1/00 - Production of fats or fatty oils from raw materials

Abstract

Provided are a phenylethanoid glycoside extract from the plant A. ilicifolius L., a preparation method thereof, and its use as an anti-liver injury medicament. The preparation method of the phenylethanoid glycoside extract comprises following steps: pulverizing dried whole plant Acanthus ilicifolius L. and passing through 20-30 mesh sieve to obtain Acanthus ilicifolius L. powder, adding 50%-95% ethanol solution whose mass is 8-20 times of the powder, soaking and extracting under reflux, filtering and collecting extract of the powder, and extracting a filter residue under reflux with 50%-95% ethanol solution whose mass is 8-10 times of the filter residue and collecting extract of the filter residue, combining, concentrating and subjecting to macroporous resin column chromatography, eluting successively by 10%, 30% and 50% ethanol solutions for four column volumes, respectively, collecting fraction eluted by the 50% ethanol solution and drying to obtain the phenylethanoid glycoside extract.

IPC Classes  ?

• A61K 36/19 - Acanthaceae (Acanthus family)
• A61K 31/7032 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

Provided by the present application is a method for preparing water-soluble astaxanthin. Said method is able to achieve mutual interaction between natural astaxanthin and a component such as a protein, a nucleic acid, or a polysaccharide naturally present within a raw material by means of mixing an astaxanthin-containing raw material and an organic acid-containing solution, then performing cell disruption, and subsequently performing leaching, thereby directly preparing water-soluble astaxanthin without needing to further perform modification on the astaxanthin. The astaxanthin is naturally sourced, the operation procedure is simple, there is a low requirement on equipment, production costs are low, the method is eco-friendly and safe, does not produce organic solvent residue, and is readily industrially implemented.

IPC Classes  ?

• C07C 403/24 - Derivatives of cyclohexane or of a cyclohexene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61P 39/06 - Free radical scavengers or antioxidants
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A23L 33/145 - Extracts

Abstract

The present disclosure relates to the field of medicinal chemistry, and specifically to brefeldin A derivatives represent by Formula (I) and its use in the inhibition of tumor proliferation activity. The new compounds provided herein are prominent in the prevention or treatment of hyperproliferative diseases, including liver cancer, leukemia, breast cancer, colon adenocarcinoma, lung cancer, Bart's esophageal cancer, gastric cancer, cervical cancer, pancreatic cancer, kidney cancer, endometrial cancer, nasopharyngeal cancer, bone cancer, lymphoma, brain cancer, nerve cancer, oral cancer and colorectal cancer, and have the potential to be developed as novel antitumor agents.

IPC Classes  ?

• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to a suspended self-orienting ducted tidal current power generation device and a control method thereof. The suspended self-orienting ducted tidal current power generation device comprises a submerged base (1), a buoy (2), a flow-guiding cover (3) and a ducted hydroelectric turbine (4). An anchor cable (5) is provided between the buoy (2) and the submerged base (1). The flow-guiding cover (3) is connected to the anchor cable (5) by means of a drawing cable (6). The ducted hydroelectric turbine (4) is provided inside the flow-guiding cover (3).

IPC Classes  ?

• F03B 13/18 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using wave energy using the relative movement between a wave-operated member and another member wherein the other member is fixed, at least at one point, with respect to the sea bed or shore
• B63B 35/44 - Floating buildings, stores, drilling platforms, or workshops, e.g. carrying water-oil separating devices

Abstract

The present application relates to a method for analyzing target nucleic acid from a cell, comprising: 1) providing the following discrete partition: target nucleic acid derived from a single cell and added with an oligonucleotide adaptor sequence, and a solid support with at least one oligonucleotide tag attached, wherein each oligonucleotide tag comprises a first strand and a second strand, the first strand comprises a barcode sequence and a hybridization sequence located at the 3'-end of the barcode sequence, the second strand comprises a first portion complementary to the hybridization sequence of the first strand and a second portion complementary to the oligonucleotide adaptor sequence attached to the target nucleic acid, and the first strand and the second strand form a partially double-stranded structure, or the second strand and the target nucleic acid attached form a partially double-stranded structure; and 2) in the discrete partition, the oligonucleotide tag is linked to the target nucleic acid attached, thereby producing barcoded target nucleic acid.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6869 - Methods for sequencing

Abstract

A long-term in-situ observation device for the deep sea bottom supported engineering geological environment is provided, including: a sediment acoustic probe, a sediment pore water pressure probe, a three-dimensional resistivity probe, a water observation instrument, a long-term observation power supply system, a probe hydraulic penetration system, a general control and data storage transmission system, an acoustic releaser, an underwater acoustic communication apparatus, and an instrument platform. The observations include the engineering properties, physical properties, mechanical properties, and biochemical properties of a seawater-seabed interface-sediment. The engineering properties and the physical and mechanical indexes of seafloor sediments are comprehensively determined by three-dimensional measurement of seafloor resistivity and acoustic wave measurements. The physical and biochemical properties of seawater are expected to be acquired by sensors. The observation probe penetrates into the sediments following the hydraulic method.

IPC Classes  ?

• G01C 13/00 - Surveying specially adapted to open water, e.g. sea, lake, river or canal
• G01D 21/02 - Measuring two or more variables by means not covered by a single other subclass
• G01L 11/02 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by means not provided for in group or by optical means
• G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
• G01V 1/38 - SeismologySeismic or acoustic prospecting or detecting specially adapted for water-covered areas
• G01V 3/12 - Electric or magnetic prospecting or detectingMeasuring magnetic field characteristics of the earth, e.g. declination or deviation operating with electromagnetic waves
• G01V 11/00 - Prospecting or detecting by methods combining techniques covered by two or more of main groups

Abstract

A seaweed fruit and vegetable formula for assisting in reducing fat and losing weight, comprising the following components in percentage by mass: Sargassum fusiforme: 95-96%; a rhizome of common turmeric extract: 2-3%; and a pomegranate rind extract: 1-2%. The rhizome of common turmeric extract and the pomegranate rind extract are compounded in the Sargassum fusiforme, and natural active substances in seaweed and fruits and vegetables are fully utilized, so that the effect of assisting in reducing fat and losing weight is achieved, and the utilization rate of natural resources is further improved. At the same time, the natural properties of seaweed and fruits and vegetables greatly reduce the toxic and side effects caused by synthetic substances, and the natural products from the seaweed and fruits and vegetables are safe, non-toxic and harmless, can achieve the purpose of assisting in reducing fat and losing weight, and can improve the health condition of people.

IPC Classes  ?

• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives

Abstract

Disclosed are a shield sealing device and a shield sealing method. An enclosing pile (10) is arranged at a shield receiving hole opening, and the shield sealing device is mounted on the enclosing pile. The shield sealing device comprises: an elastic inner ring (30), the inner wall of the elastic inner ring matching the outer wall of a cutter head (50) of a shield machine; and a plurality of control parts (20), the control parts being mounted on the enclosing pile and arranged at intervals in the circumferential direction of the elastic inner ring, and the driving ends of the control parts pressing against the outer side of the elastic inner ring so as to press or release the elastic inner ring. When the shield machine travels, the inner diameter of the shield machine is gradually reduced when the shield machine passes through the hole opening, and the elastic inner ring is pressed by the control parts, such that the elastic inner ring is attached to the side wall of the shield machine, a good hole opening sealing effect is achieved, water leakage and slurry leakage are prevented, manual plate insertion is not required, and the operation is convenient.

IPC Classes  ?

• E21D 9/06 - Making by using a driving shield
• E21D 11/38 - WaterproofingHeat insulatingSoundproofingElectric insulating

Abstract

A method for sampling the sea surface microlayer, comprising: step S1: placing a sampling device at a working position above the sea surface; step S2: determining the lowest position, the highest position and the operating speed of a sampling board (3); step S3: a lifting system driving the sampling board (3) to move perpendicular to the sea surface down to the lowest position; step S4: the lifting system driving the sampling board (3) to move perpendicular to the sea surface up to the highest position, and when the sampling board (3) moves to the highest position, a drive mechanism driving a liquid collection tank (16) to rotate so that a side at the top of the liquid collection tank (16) close to a glass plate (13) presses against the glass plate (13); step S5: the lifting system driving the sampling board (3) to move perpendicular to the sea surface down to the lowest position, and while moving down, the side at the top of the liquid collection tank (16) that presses against the glass plate (13) scraping the surface liquid on the glass plate (13) for liquid collection, the liquid being collected into the liquid collection tank (16), and the liquid inside of the liquid collection tank (16) being guided to flow into a collection bottle (6); and step S6: stopping sampling. The described sampling method features high automation, high efficiency of sampling, and ideal sampling thickness, which can meet requirements.

IPC Classes  ?

• G01N 1/20 - Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials

Abstract

A method for sampling the sea surface microlayer, comprising: step S1: placing a sampling device at a working position above the sea surface; step S2: determining the lowest position, the highest position and the operating speed of a sampling board (3); step S3: a lifting system driving the sampling board (3) to move perpendicular to the sea surface down to the lowest position; step S4: the lifting system driving the sampling board (3) to move perpendicular to the sea surface up to the highest position, and when the sampling board (3) moves to the highest position, a drive mechanism driving a liquid collection tank (16) to rotate so that a side at the top of the liquid collection tank (16) close to a glass plate (13) presses against the glass plate (13); step S5: the lifting system driving the sampling board (3) to move perpendicular to the sea surface down to the lowest position, and while moving down, the side at the top of the liquid collection tank (16) that presses against the glass plate (13) scraping the surface liquid on the glass plate (13) for liquid collection, the liquid being collected into the liquid collection tank (16), and the liquid inside of the liquid collection tank (16) being guided to flow into a collection bottle (6); and step S6: stopping sampling. The described sampling method features high automation, high efficiency of sampling, and ideal sampling thickness, which can meet requirements.

IPC Classes  ?

• G01N 1/20 - Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials

Abstract

The disclosure discloses a method and application for rapid and accurate chromosomal location of economic traits in laver, belonging to the fields of genomics and molecular breeding, wherein comprising the following steps: distinguishing the different genotype sectors by the color difference of pigment mutants, releasing monospores based on the asexual reproduction of single-genotype sectors, forming offspring CMD population; performing QTL-seq analysis on the extreme phenotype pools of offspring CMD population by SNP/InDel markers; and combining KASP and RNA-seq to predict the location of the genes of discrete traits or major QTL. The disclosure may solve the problem of difficulty in genetic analysis of various traits caused by the genotypic chimeric haploid characteristics.

IPC Classes  ?

• C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
• C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
• C12Q 1/686 - Polymerase chain reaction [PCR]

Abstract

A bottom boundary layer in-situ observation system suitable for shallow-water viscous seabed, and an arrangement method therefor. By means of freely assembling stainless steel pipes, an instrument arrangement area (5) and a turbulence-free observation area (6) are constructed, integration of various instruments is achieved, and a turbulence influence of an instrument rack body on an observation space is avoided; the instrument arrangement area (5) can be adjusted and combined according to user requirements; supporting legs of a observation rack and top ends of bottom columns are systematically fixed by means of foot plates, limitation by the weight of the observation system itself is avoided, and defects of a settlement plate are overcome. All the components are convenient to replace or maintain, the cost is low, said observation system can be widely applied, and the problems in terms of full-layer, multi-parameter, continuality, stability and high costs of bottom boundary layer in-situ observation are effectively solved.

IPC Classes  ?

• G01C 13/00 - Surveying specially adapted to open water, e.g. sea, lake, river or canal
• E02D 7/00 - Methods or apparatus for placing sheet pile bulkheads, piles, mould-pipes, or other moulds

Abstract

The present invention relates to a cryptotanshinone derivative, a preparation method therefor and an application thereof in resisting neuroinflammation and neuroprotection. The cryptotanshinone derivative has the structure as shown in formula I: (I). The present invention provides three novel anti-neuroinflammatory and neuroprotective agents, characterized in: using the cryptotanshinone derivative having the structure as shown in formula I or salts thereof in the present invention as an effective component for preventing or treating neurodegenerative disorders related to neuroinflammation such as Alzheimer's disease and parkinsonism.

IPC Classes  ?

• C07J 73/00 - Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• C12P 17/04 - Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin
• C12R 1/645 - Fungi

Abstract

A system and a method for monitoring a health state of an offshore wind power wind turbine and sound waves of sea waves. The system comprises a first laser emitter (1) and a second laser emitter (2) which are mounted at the bottom of a nacelle of a wind turbine and can emit lasers vertically downwards, a long-focal-length camera (3) mounted on a hub, a shaking detection sensor (4) mounted on a tower of the wind turbine, and four acoustic detection sensors (5) provided at intervals of 90° along the periphery of the tower, the first laser emitter, the second laser emitter, the long-focal-length camera, the shaking detection sensor, and the acoustic detection sensor being connected to a data collection and conversion module (7) by means of a transmission module (6). The monitoring system can improve, on the basis of laser detection and acoustic signal feature detection, the stability and safety of an offshore wind power generator; in addition, the four acoustic detection sensors of the monitoring system are arranged at intervals of 90° at right angles, so that the monitoring system can still effectively detect the noise of the wind turbine when the wind turbine yaws.

IPC Classes  ?

• F03D 17/00 - Monitoring or testing of wind motors, e.g. diagnostics

Abstract

Provided are an enzyme having an acyl group transfer function as well as a mutant and application thereof, an amino acid sequence of the acyltransferase being that of SEQ ID NO: 1, and same being able to perform acylation on Macrolactins and Filipins macrolide compounds, Chloramphenicol, and Glycosylated piericidin A. Further provided is a method for combining an acyl group of an acyl group donor to a macrolide compound by using said acyltransferase.

IPC Classes  ?

• C12N 9/10 - Transferases (2.)
• C12N 15/54 - Transferases (2)
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12P 17/08 - Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
• C12P 13/02 - Amides, e.g. chloramphenicol
• C12R 1/19 - Escherichia coli

Abstract

A wind generator blade state of health monitoring apparatus and monitoring method, the monitoring apparatus being mounted on a wind generator tower at a position opposite wind generator blades, and comprising a housing (1), an image acquisition apparatus (2) and a sound acquisition apparatus (3) mounted on the housing at a position facing the blades, and a central processing unit (4), a memory (5), a communication unit (6), a GPS and a power supply (7) mounted in the housing, the central processing unit being electrically connected to both the image acquisition apparatus and the sound acquisition apparatus and controlling operation thereof, electrically connected to the memory and performing data reading and writing, electrically connected to the communication unit so as to facilitate external communication, and electrically connected to the GPS so as to acquire a location, and the power supply providing power to a detection apparatus. The wind generator blade state of health monitoring apparatus is easy to implement on the basis of an existing operation platform, such as a smartphone; is mounted on a wind generator tower by means of a magnetic ring, making mounting and moving easy; and a camera and microphone used thereby may easily complete image and sound signal collection.

IPC Classes  ?

• F03D 17/00 - Monitoring or testing of wind motors, e.g. diagnostics
• F03D 7/04 - Automatic controlRegulation

Abstract

The present invention provides a five-component marine natural gas hydrate intelligent sensing node, comprising a titanium alloy compartment, an information acquisition unit, an integrated control chip, and a power module; the integrated control chip comprises an intelligent computing unit and a transmission unit; the intelligent computing unit is configured for acquiring quality monitoring indicators of marine natural gas hydrates by feature extraction and transmitting reduced represented features to a monitoring device on the sea surface via the transmission unit. The present invention has overcome problems of impossible timely quality monitoring due to blind acquisition process, promised a controllable undersea node working status, and acquired data are complete without any loss, which doesn't only facilitate nonconventional energy resources such as marine hydrates prospection, and is also of great application prospect and value in oil and gas resources exploration, geological hazards precautions and evaluation.

IPC Classes  ?

• G01V 1/38 - SeismologySeismic or acoustic prospecting or detecting specially adapted for water-covered areas
• G01V 1/20 - Arrangements of receiving elements, e.g. geophone pattern

Abstract

A combined duck-type wave energy power generation apparatus and a power generation method. The power generation apparatus comprises a hydraulic energy capturing system (100) and a mechanical energy capturing system (400). The hydraulic energy capturing system (100) is mounted on an ocean platform, and has a nodding duck floating body (300) and a cantilever connection mechanism (200) connected to the nodding duck floating body (300); the mechanical energy capturing system (400) is mounted at the interior of the nodding duck floating body (300), and has a differential integration mechanism (600) and a commutation speed increasing mechanism (500). In the power generation apparatus and the power generation method, two power generation modes are combined, and ocean wave energy is effectively used.

IPC Classes  ?

• F03B 13/18 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using wave energy using the relative movement between a wave-operated member and another member wherein the other member is fixed, at least at one point, with respect to the sea bed or shore

Abstract

The present invention relates to a phenylethanoid glycoside extract from Acanthus ilicifolius, and a preparation method thereof and application as a drug for resisting liver damage, the preparation method of the phenylethanoid glycoside extract comprising the following steps: crushing a dried whole Acanthus ilicifolius plant; passing through a 20-30 mesh sieve to obtain Acanthus ilicifolius powder; adding a 50%-95% ethanol solution of 8-20 times the mass of the powder; after soaking for 1-3 h, performing reflux extraction for 2-4h; filtering and collecting the extract; performing reflux extraction on the filtration residue with 8-10 times the mass of 50%-95% ethanol solution for 1.5-2 h; combining the two extraction liquids; after concentration, subjecting to macroporous resin column chromatography; eluting with 10%, 30%, and 50% ethanol solution in succession; collecting four column volumes for each gradient; concentrating and drying the fraction obtained by collecting the 50% ethanol solution elution to obtain a phenylethanoid glycoside extract.

IPC Classes  ?

• A61K 36/19 - Acanthaceae (Acanthus family)
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• G01N 30/02 - Column chromatography
• G01N 30/86 - Signal analysis

Abstract

The present disclosure relates to the field of pharmaceutical chemistry, and specifically relates to a use of a brefeldin A ester derivative in inhibiting tumor proliferation activity, the structure of said brefeldin A ester derivative being as shown in formula (I). The present novel compound features a pronounced effect in preventing or treating hyperproliferative diseases, including liver cancer, leukemia, breast cancer, colonic adenocarcinoma, stomach cancer, lung cancer, Barrett's esophagus cancer, cervical cancer, pancreatic cancer, endometrial cancer, bone cancer, lymphoma, kidney cancer, brain cancer, neural cancer, nasopharyngeal cancer, oral cancer, and/or colorectal cancer, thus having portential for being developed as a novel anti-tumor drug.

IPC Classes  ?

• C07D 313/00 - Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
• A61K 31/365 - Lactones
• A61P 35/00 - Antineoplastic agents

Abstract

Provided are a Brefeldin A derivative as represented in formula (I) and a use thereof in inhibiting the activities of tumor proliferation. The compound has substantial effect in the prevention and treatment of hyperproliferation diseases, including liver cancer, leukemia, breast cancer, colon adenocarcinoma, lung cancer, Barrett's esophageal cancer, gastric cancer, cervical cancer, pancreatic cancer, kidney cancer, endometrial cancer, nasopharyngeal carcinoma, bone cancer, lymphatic cancer, brain cancer, neuroendocrine cancer, oral cancer, and colon and rectum cancer, and has the potential to be developed as an anti-tumor medication.

IPC Classes  ?

• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to the field of genetic engineering and fermentation engineering, and provided are glucose oxidase M5GOD, a coding gene thereof and an application thereof. Provided is an amino acid sequence, represented by SEQ ID NO. 2, of the glucose oxidase, and further provided is a nucleotide sequence, represented by SEQ ID NO. 4, of a coding gene that encodes the glucose oxidase. A recombinant vector and a recombinant strain containing the gene and an application thereof. The glucose oxidase has good properties, an optimum pH of 5.5, optimum temperature of 30°C and relatively good low-temperature adaptability. As an enzyme preparation, the glucose oxidase can be widely applied to the feed, food, and pharmaceutical industries, and so on.

IPC Classes  ?

• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 15/53 - Oxidoreductases (1)
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12R 1/84 - Pichia

Abstract

Disclosed is a method for rapid nondestructive testing of a living body and evaluation of shellfish muscle mass. The method comprises: setting an X-ray radioactive source and digital imaging parameters, and performing muscle living body identification and cross-sectional area measurement. According to the method, a clear image and accurate measurement data of the cross section of shellfish muscle can be obtained in a nondestructive manner, and the muscle mass is evaluated, such that the problem that it is not possible for a measured individual to survive and to be used as a breeding parent due to the fact that a traditional shellfish muscle property measuring method requires dissection is solved, and research on living shellfish muscle properties thus becomes possible, thereby greatly improving the efficiency of high-muscle-mass shellfish selective breeding cultivation.

IPC Classes  ?

• G01N 23/04 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material
• G01B 15/04 - Measuring arrangements characterised by the use of electromagnetic waves or particle radiation, e.g. by the use of microwaves, X-rays, gamma rays or electrons for measuring contours or curvatures

Abstract

Provided in the present invention are a medicament for effectively killing drug-resistant disease bacteria and an application thereof in inhibiting drug-resistant disease bacteria. Specifically, provided in the present invention is a composition for killing or inhibiting disease bacteria, which comprises an active combination that consists of a first active ingredient TPAD and a second active ingredient QseC/B signaling pathway inhibitor.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61K 31/18 - Sulfonamides
• A61P 31/04 - Antibacterial agents
• C07C 335/16 - Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton

Abstract

An interactive intensive learning method that combines a TAMER framework and facial expression feedback, comprising: forming a Face Valuing-TAMER agent by combining a TAMER framework and facial expression evaluation; and the Face Valuing-TAMER agent expects a future reward from a learning value function in human feedback. A human trainer first trains an agent in a TAMER framework and provides a reward signal by means of keyboard key feedback, and the trained agent acquires an initial executable strategy and then allows the human trainer to provide a reward by means of facial expression feedback so as to adjust the behavior of the agent. Cognitive burden during a process in which a human user trains an agent may be reduced by means of the facial expression feedback-based interactive intensive learning method, so that the agent can better understand human preferences and effectively learn from human rewards.

IPC Classes  ?

• G06N 20/00 - Machine learning

Abstract

A heaving float-type power generation and oxygenation device and method, comprising an energy capturing system as well as a reversing system, oxygenation system and power generation system which are located in the energy capturing system. The energy capturing system is provided with a steel frame (101), a heaving float (102), a lead screw (103), a flexible waterproof housing (105) and a base (106). The reversing system comprises a sleeve shaft (201), a reversing wheel (202), a lead screw gear (203), a ratchet wheel (204) and an output shaft (205). The oxygenation system is provided with an air intake pipe (302), a one-way air intake solenoid valve (303), an upper air outlet pipe (304), a lower air outlet pipe (305), a lower one-way air outlet solenoid valve (306) and an upper one-way air outlet solenoid valve (307). The power generation system is located at the upper end of the output shaft (205). The present device implements wave energy capturing and transmission by means of a simple and inexpensive lead screw gear transmission mechanism, and simultaneously achieves the dual functions of power generation and oxygenation.

IPC Classes  ?

• F03B 13/18 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using wave energy using the relative movement between a wave-operated member and another member wherein the other member is fixed, at least at one point, with respect to the sea bed or shore
• A01K 63/04 - Arrangements for treating water specially adapted to receptacles for live fish
• C02F 7/00 - Aeration of stretches of water

Abstract

By establishing effective methods for shrimp 3D cell culture and passage, the present invention provides a technology of continuous shrimp cell culture intended for the establishment of immortalized shrimp cell lines. The present invention provides a preparation method of matrigel for 3D cell culture of shrimp by optimizing an additive proportion of matrigel. The present invention further provides a technology of separation and 3D cell culture of shrimp haemolymph cells, where shrimp haemolymph cells adhere to and grow on the surface of the matrigel in the form of a single round cell and a cell pellet/cellular spheroid, with survival and growth abilities being superior to 2D culture effects. The above technology is achieved by optimizing a formula of complete medium for shrimp cells, selecting the medium as an anticoagulant and a diluent for shrimp haemolymph cells, selecting a 3D culture method for surface-adhered growth in the matrigel.

IPC Classes  ?

• C12N 5/07 - Animal cells or tissues