Goods & Services

Collagen for medical purposes; biodegradable implants for use in guided tissue regeneration; surgical implants grown from stem cells; therapeutic drugs and agents; pharmaceutical and medical preparations; surgical and medical dressings; biological preparations for medical purposes; biological preparations for medical use; dental implant materials; collagen bioinks in the nature of biological tissue cells for clinical purposes; collagen bioinks in the nature of biological tissues for clinical purposes; engineered human biological tissues for use in regenerative medicine; engineered animal biological tissues for use in regenerative medicine; biomaterials in the nature of biological tissue cells for medical purposes; biological implants; engineered biological tissues for medical purposes; biological implants comprised of human or animal connective tissues; biological tissue for implantation; surgical implants comprising living tissue; surgical mesh comprised primarily of living tissue; biotechnological preparations for medical purposes. Orthopaedic apparatus; orthopaedic articles; surgical implants comprised of artificial materials for use in guided tissue regeneration; artificial orthopaedic implants; medical implants made from artificial materials; surgical implants comprised of artificial materials; orthopedic implants; otological prostheses; dental implants [prostheses]; implants [prostheses] for use in the body; implants [prostheses] for bone surgery; implants [prostheses] for dental surgery; implants [prostheses] for use in bone grafting; implants [prostheses] for use in facial surgery; artificial surgical implants; therapeutic articles for implantation made of artificial materials.

Goods & Services

Collagen for medical purposes; surgical implants grown from stem cells; therapeutic drugs and agents; pharmaceutical and medical preparations; surgical and medical dressings; biological preparations for medical purposes; biological preparations for medical use; dental implant materials; collagen bioinks in the nature of biological tissues for clinical purposes; biological implants comprised of human or animal connective tissues; biological implants; surgical implants comprised of living tissues; surgical mesh comprised primarily of living tissue; biotechnological preparations for medical purposes; biodegradable implants for use in guided tissue regeneration; collagen bioinks in the nature of biological tissue cells for clinical purposes; engineered human biological tissues for use in regenerative medicine; engineered animal biological tissues for use in regenerative medicine; biomaterials in the nature of biological tissue cells for medical purposes; biological tissue for implantation; engineered biological tissues for medical purposes. Orthopaedic apparatus; orthopaedic articles; medical implants made from artificial materials; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for use in guided tissue regeneration; orthopaedic implants; artificial orthopaedic implants; implants [prostheses] for use in the body; implants [prostheses] for dental surgery; implants [prostheses] for bone surgery; implants [prostheses] for use in facial surgery; implants [prostheses] for use in bone grafting; otological prostheses; dental implants [prostheses]; artificial surgical implants; therapeutic articles for implantation made of artificial materials.

Goods & Services

Collagen for medical purposes; biodegradable implants for use in guided tissue regeneration; surgical implants grown from stem cells; therapeutic drugs and agents; pharmaceutical and medical preparations; surgical and medical dressings; biological preparations for medical purposes; biological preparations for medical use; dental implant materials; collagen bioinks in the nature of biological tissue cells for clinical purposes; collagen bioinks in the nature of biological tissues for clinical purposes; engineered human biological tissues for use in regenerative medicine; engineered animal biological tissues for use in regenerative medicine; biological implants comprised of human or animal connective tissues; biological implants; biomaterials in the nature of biological tissue cells for medical purposes; biological tissue for implantation; engineered biological tissues for medical purposes; surgical implants comprising living tissue; surgical mesh comprised primarily of living tissue; biotechnological preparations for medical purposes. Artificial orthopaedic implants; orthopaedic apparatus; orthopaedic articles; medical implants made from artificial materials; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for use in guided tissue regeneration; orthopaedic implants; otological prostheses; dental implants [prostheses]; implants [prostheses] for use in the body; implants [prostheses] for bone surgery; implants [prostheses] for dental surgery; implants [prostheses] for use in bone grafting; implants [prostheses] for use in facial surgery; artificial surgical implants; therapeutic articles for implantation made of artificial materials.

Goods & Services

Collagen for medical purposes; biodegradable implants for use in guided tissue regeneration; surgical implants grown from stem cells; therapeutic drugs and agents; pharmaceutical and medical preparations; surgical and medical dressings; biological preparations for medical purposes; biological preparations for medical use; dental implant materials; collagen bioinks in the nature of biological tissue cells for clinical purposes; collagen bioinks in the nature of biological tissues for clinical purposes; engineered human biological tissues for use in regenerative medicine; engineered animal biological tissues for use in regenerative medicine; biological implants comprised of human or animal connective tissues; biological implants; biomaterials in the nature of biological tissue cells for medical purposes; biological tissue for implantation; engineered biological tissues for medical purposes; surgical implants comprising living tissue; surgical mesh comprised primarily of living tissue; biotechnological preparations for medical purposes. Medical implants made from artificial materials; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for use in guided tissue regeneration; orthopaedic implants; artificial orthopaedic implants; orthopaedic apparatus; orthopaedic articles; otological prostheses; dental implants [prostheses]; implants [prostheses] for dental surgery; implants [prostheses] for use in facial surgery; implants [prostheses] for use in the body; implants [prostheses] for bone surgery; implants [prostheses] for use in bone grafting; artificial surgical implants; therapeutic articles for implantation made of artificial materials.

Goods & Services

Collagen for medical purposes; biodegradable implants for use in guided tissue regeneration; surgical implants grown from stem cells; therapeutic drugs and agents; pharmaceutical and medical preparations; surgical and medical dressings; biological preparations for medical purposes; biological preparations for medical use; dental implant materials; collagen bioinks in the nature of biological tissue cells for clinical purposes; collagen bioinks in the nature of biological tissues for clinical purposes; engineered human biological tissues for use in regenerative medicine; engineered animal biological tissues for use in regenerative medicine; biomaterials in the nature of biological tissue cells for medical purposes; biological implants; engineered biological tissues for medical purposes; biological implants comprised of human or animal connective tissues; biological tissue for implantation; surgical implants comprising living tissue; surgical mesh comprised primarily of living tissue; biotechnological preparations for medical purposes. Orthopaedic apparatus; orthopaedic articles; surgical implants comprised of artificial materials for use in guided tissue regeneration; artificial orthopaedic implants; medical implants made from artificial materials; surgical implants comprised of artificial materials; orthopedic implants; otological prostheses; dental implants [prostheses]; implants [prostheses] for use in the body; implants [prostheses] for bone surgery; implants [prostheses] for dental surgery; implants [prostheses] for use in bone grafting; implants [prostheses] for use in facial surgery; artificial surgical implants; therapeutic articles for implantation made of artificial materials.

Goods & Services

Collagen for medical purposes; surgical implants grown from stem cells being living tissue; therapeutic drugs and agents for use in tissue repair and regeneration; pharmaceutical and medical preparations for use in regeneration of damaged bone and soft tissue, including nerve tissue; surgical and medical dressings; biological preparations for medical purposes, namely, for use in tissue regeneration for tissue repair; biological preparations for medical use, namely, for use in tissue regeneration for tissue repair; dental implant materials being implantable scaffolds comprising biological materials including living cells and collagen; collagen bioinks in the nature of biological tissues intended for subsequent implantation for clinical purposes; biological implants comprised of human or animal connective tissues intended for subsequent implantation; biological implants, namely, living cells and implantable scaffolds comprising biological materials for use in human tissue regeneration and repair; surgical implants comprised of living tissues; surgical mesh comprised primarily of living tissue; biotechnological preparations for medical purposes, namely, living cells and implantable scaffolds comprising biological materials for use in human tissue regeneration and repair; biodegradable implants for use in guided tissue regeneration, namely, living cells and implantable scaffolds comprising biological materials for use in human tissue regeneration and repair; collagen bioinks in the nature of biological tissue cells intended for subsequent implantation for clinical purposes; engineered human biological tissues being living cells and implantable scaffolds comprising biological materials for use in regenerative medicine; engineered animal biological tissues being living cells and implantable scaffolds comprising biological materials for use in regenerative medicine; biomaterials in the nature of biological tissue cells being living cells for medical purposes; biological tissue being living cells for implantation for use in tissue regeneration for tissue repair; engineered biological tissues being living cells for medical purposes Orthopaedic apparatus, namely, apparatus made from artificial biomaterials for use in the regeneration of bone and soft tissue, including nerve tissue; orthopaedic articles, namely, apparatus made from artificial biomaterials for use in the regeneration of bone and soft tissue, including nerve tissue; medical implants made from artificial materials; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for use in guided tissue regeneration; orthopaedic implants, namely, implants made from artificial biomaterials for use in the regeneration of bone and soft tissue, including nerve tissue; artificial orthopaedic implants, namely, implants made from artificial biomaterials for use in the regeneration of bone and soft tissue, including nerve tissue; implants being prostheses of artificial biomaterials, namely, bone prostheses and soft tissue prostheses for replacing bone and soft tissue for use in the body; implants being prostheses of artificial biomaterials, namely, dental prostheses for dental surgery; implants being prostheses of artificial biomaterials, namely, bone prostheses for bone surgery; implants being prostheses of artificial biomaterials, namely, dental and bone prostheses for use in facial surgery; implants being prostheses of artificial biomaterials, namely, bone prostheses for use in bone grafting; otological prostheses being prostheses consisting of artificial biomaterials; dental implants; artificial surgical implants comprising artificial biomaterials; therapeutic articles for implantation, namely, surgical implants, made of artificial materials

Goods & Services

Collagen for medical purposes; surgical implants grown from stem cells being living tissue; therapeutic drugs and agents for use in tissue repair and regeneration; pharmaceutical and medical preparations for use in regeneration of damaged bone and soft tissue, including nerve tissue; surgical and medical dressings; biological preparations for medical purposes, namely, for use in tissue regeneration for tissue repair; biological preparations for medical use, namely, for use in tissue regeneration for tissue repair; dental implant materials being implantable scaffolds comprising biological materials including living cells and collagen; collagen bioinks in the nature of biological tissues intended for subsequent implantation for clinical purposes; biological implants comprised of human or animal connective tissues intended for subsequent implantation; biological implants, namely, living cells and implantable scaffolds comprising biological materials for use in human tissue regeneration and repair; surgical implants comprised of living tissues; surgical mesh comprised primarily of living tissue; biotechnological preparations for medical purposes, namely, living cells and implantable scaffolds comprising biological materials for use in human tissue regeneration and repair; biodegradable implants for use in guided tissue regeneration, namely, living cells and implantable scaffolds comprising biological materials for use in human tissue regeneration and repair; collagen bioinks in the nature of biological tissue cells intended for subsequent implantation for clinical purposes; engineered human biological tissues being living cells and implantable scaffolds comprising biological materials for use in regenerative medicine; engineered animal biological tissues being living cells and implantable scaffolds comprising biological materials for use in regenerative medicine; biomaterials in the nature of biological tissue cells being living cells for medical purposes; biological tissue being living cells for implantation for use in tissue regeneration for tissue repair; engineered biological tissues being living cells for medical purposes Orthopaedic apparatus, namely, apparatus made from artificial biomaterials for use in the regeneration of bone and soft tissue, including nerve tissue; orthopaedic articles, namely, apparatus made from artificial biomaterials for use in the regeneration of bone and soft tissue, including nerve tissue; medical implants made from artificial materials; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for use in guided tissue regeneration; orthopaedic implants, namely, implants made from artificial biomaterials for use in the regeneration of bone and soft tissue, including nerve tissue; artificial orthopaedic implants, namely, implants made from artificial biomaterials for use in the regeneration of bone and soft tissue, including nerve tissue; implants being prostheses of artificial biomaterials, namely, bone prostheses and soft tissue prostheses for replacing bone and soft tissue for use in the body; implants being prostheses of artificial biomaterials, namely, dental prostheses for dental surgery; implants being prostheses of artificial biomaterials, namely, bone prostheses for bone surgery; implants being prostheses of artificial biomaterials, namely, dental and bone prostheses for use in facial surgery; implants being prostheses of artificial biomaterials, namely, bone prostheses for use in bone grafting; otological prostheses being prostheses consisting of artificial biomaterials; dental implants; artificial surgical implants comprising artificial biomaterials; therapeutic articles for implantation, namely, surgical implants, made of artificial materials

Goods & Services

(1) Collagen for medical purposes; surgical implants grown from stem cells; therapeutic drugs and agents; pharmaceutical and medical preparations; surgical and medical dressings; biological preparations for medical purposes; biological preparations for medical use; dental implant materials; collagen bioinks in the nature of biological tissues for clinical purposes; biological implants comprised of human or animal connective tissues; biological implants; surgical implants comprised of living tissues; surgical mesh comprised primarily of living tissue; biotechnological preparations for medical purposes; biodegradable implants for use in guided tissue regeneration; collagen bioinks in the nature of biological tissue cells for clinical purposes; engineered human biological tissues for use in regenerative medicine; engineered animal biological tissues for use in regenerative medicine; biomaterials in the nature of biological tissue cells for medical purposes; biological tissue for implantation; engineered biological tissues for medical purposes. (2) Orthopaedic apparatus; orthopaedic articles; medical implants made from artificial materials; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for use in guided tissue regeneration; orthopaedic implants; artificial orthopaedic implants; implants [prostheses] for use in the body; implants [prostheses] for dental surgery; implants [prostheses] for bone surgery; implants [prostheses] for use in facial surgery; implants [prostheses] for use in bone grafting; otological prostheses; dental implants [prostheses]; artificial surgical implants; therapeutic articles for implantation made of artificial materials.

Goods & Services

(1) Collagen for medical purposes; biodegradable implants for use in guided tissue regeneration; surgical implants grown from stem cells; therapeutic drugs and agents; pharmaceutical and medical preparations; surgical and medical dressings; biological preparations for medical purposes; biological preparations for medical use; dental implant materials; collagen bioinks in the nature of biological tissue cells for clinical purposes; collagen bioinks in the nature of biological tissues for clinical purposes; engineered human biological tissues for use in regenerative medicine; engineered animal biological tissues for use in regenerative medicine; biomaterials in the nature of biological tissue cells for medical purposes; biological implants; engineered biological tissues for medical purposes; biological implants comprised of human or animal connective tissues; biological tissue for implantation; surgical implants comprising living tissue; surgical mesh comprised primarily of living tissue; biotechnological preparations for medical purposes. (2) Orthopaedic apparatus; orthopaedic articles; surgical implants comprised of artificial materials for use in guided tissue regeneration; artificial orthopaedic implants; medical implants made from artificial materials; surgical implants comprised of artificial materials; orthopedic implants; otological prostheses; dental implants [prostheses]; implants [prostheses] for use in the body; implants [prostheses] for bone surgery; implants [prostheses] for dental surgery; implants [prostheses] for use in bone grafting; implants [prostheses] for use in facial surgery; artificial surgical implants; therapeutic articles for implantation made of artificial materials.

Goods & Services

(1) Collagen for medical purposes; biodegradable implants for use in guided tissue regeneration; surgical implants grown from stem cells; therapeutic drugs and agents; pharmaceutical and medical preparations; surgical and medical dressings; biological preparations for medical purposes; biological preparations for medical use; dental implant materials; collagen bioinks in the nature of biological tissue cells for clinical purposes; collagen bioinks in the nature of biological tissues for clinical purposes; engineered human biological tissues for use in regenerative medicine; engineered animal biological tissues for use in regenerative medicine; biological implants comprised of human or animal connective tissues; biological implants; biomaterials in the nature of biological tissue cells for medical purposes; biological tissue for implantation; engineered biological tissues for medical purposes; surgical implants comprising living tissue; surgical mesh comprised primarily of living tissue; biotechnological preparations for medical purposes. (2) Medical implants made from artificial materials; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for use in guided tissue regeneration; orthopaedic implants; artificial orthopaedic implants; orthopaedic apparatus; orthopaedic articles; otological prostheses; dental implants [prostheses]; implants [prostheses] for dental surgery; implants [prostheses] for use in facial surgery; implants [prostheses] for use in the body; implants [prostheses] for bone surgery; implants [prostheses] for use in bone grafting; artificial surgical implants; therapeutic articles for implantation made of artificial materials.

Goods & Services

(1) Collagen for medical purposes; biodegradable implants for use in guided tissue regeneration; surgical implants grown from stem cells; therapeutic drugs and agents; pharmaceutical and medical preparations; surgical and medical dressings; biological preparations for medical purposes; biological preparations for medical use; dental implant materials; collagen bioinks in the nature of biological tissue cells for clinical purposes; collagen bioinks in the nature of biological tissues for clinical purposes; engineered human biological tissues for use in regenerative medicine; engineered animal biological tissues for use in regenerative medicine; biological implants comprised of human or animal connective tissues; biological implants; biomaterials in the nature of biological tissue cells for medical purposes; biological tissue for implantation; engineered biological tissues for medical purposes; surgical implants comprising living tissue; surgical mesh comprised primarily of living tissue; biotechnological preparations for medical purposes. (2) Artificial orthopaedic implants; orthopaedic apparatus; orthopaedic articles; medical implants made from artificial materials; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for use in guided tissue regeneration; orthopaedic implants; otological prostheses; dental implants [prostheses]; implants [prostheses] for use in the body; implants [prostheses] for bone surgery; implants [prostheses] for dental surgery; implants [prostheses] for use in bone grafting; implants [prostheses] for use in facial surgery; artificial surgical implants; therapeutic articles for implantation made of artificial materials.

Goods & Services

Collagen for medical purposes; biodegradable implants for use in guided tissue regeneration; surgical implants grown from stem cells; therapeutic drugs and agents; pharmaceutical and medical preparations; surgical and medical dressings; biological preparations for medical purposes; biological preparations for medical use; dental implant materials; collagen bioinks in the nature of biological tissue cells for clinical purposes; collagen bioinks in the nature of biological tissues for clinical purposes; engineered human biological tissues for use in regenerative medicine; engineered animal biological tissues for use in regenerative medicine; biological implants comprised of human or animal connective tissues; biological implants; biomaterials in the nature of biological tissue cells for medical purposes; biological tissue for implantation; engineered biological tissues for medical purposes; surgical implants comprising living tissue; surgical mesh comprised primarily of living tissue; biotechnological preparations for medical purposes Artificial orthopaedic implants; orthopaedic apparatus; orthopaedic articles; medical implants made from artificial materials; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for use in guided tissue regeneration; orthopaedic implants; otological prostheses; dental implants [prostheses]; implants [prostheses] for use in the body; implants [prostheses] for bone surgery; implants [prostheses] for dental surgery; implants [prostheses] for use in bone grafting; implants [prostheses] for use in facial surgery; artificial surgical implants; therapeutic articles for implantation made of artificial materials

Abstract

The subject invention relates generally to the repair of severed or damaged nerve and/or epineurium in a patient in need of such treatment. In particular, the present invention provides devices and methods of repairing severed or damaged nerve and/or epincurium. In some embodiments, a device is provided for the in vivo repair of severed or damaged nerve and/or epineurium comprising: a pliable collagen membrane comprising a first surface and a second surface, said first surface having a plurality of protruding collagen bundles and said second surface comprising a plurality of apertures, said apertures and said collagen bundles arranged to form a self-engaging attachment when said first surface and said second surface are placed together.

IPC Classes  ?

• A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
• A61L 27/24 - Collagen

Goods & Services

(1) Stem cells for medical purposes; collagen for medical use; biodegradable implants for use in guided tissue regeneration; implant materials for use in guided tissue regeneration in surgery; implantable materials for use in guided tissue regeneration; implants for guided tissue regeneration; surgical implants grown from stem cells (living tissues); therapeutic agents (medical); therapeutic biological products (medical); medical preparations; guided tissue regeneration materials; biological preparations for medical purposes; tissue-regenerative medical preparations; tissues for medical use; surgical dressings incorporating collagen; surgical dressings made from collagen; tissue-regenerative pharmaceutical preparations; tissues for surgical use. (2) Artificial orthopaedic implants; biodegradable bone fixation implants; dental implants; medical implants; orthopaedic implants; surgical implants (prosthesis) for use in human medicine; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for replacing human tissue; surgical implants comprised of artificial materials for use in guided tissue regeneration; surgical prostheses; artificial skin for surgical purposes; orthopaedic materials; artificial materials for use in guided tissue regeneration; artificial replacement materials for human tissue; replacement materials for animal tissue.

Goods & Services

(1) Stem cells for medical purposes; collagen for medical use; biodegradable implants for use in guided tissue regeneration; implant materials for use in guided tissue regeneration in surgery; implantable materials for use in guided tissue regeneration; implants for guided tissue regeneration; surgical implants grown from stem cells (living tissues); therapeutic agents (medical); therapeutic biological products (medical); medical preparations; guided tissue regeneration materials; biological preparations for medical purposes; tissue-regenerative medical preparations; tissues for medical use; collagen based scaffolding for biomechanical support and stabilisation; cellular therapeutic tendon and cartilage regeneration products. (2) Medical implants; orthopaedic implants; surgical implants comprised of artificial materials; dental implants; biodegradable bone fixation implants; surgical implants comprised of artificial materials for use in guided tissue regeneration; surgical implants comprised of artificial materials for replacing human tissue; surgical prostheses; artificial skin for surgical purposes; surgical implants (prosthesis) for use in human medicine; orthopaedic materials; artificial orthopaedic implants; artificial materials for use in guided tissue regeneration; artificial replacement materials for human tissue; replacement materials for animal and human tissue. (1) Advisory services relating to medical services; medical services; medical advisory services; medical care services; medical health assessment services; medical treatment services; provision of medical information; provision of medical services; therapy services; physical therapy; medical services, including those relating to biomechanical and cellular therapeutic medical techniques.

Abstract

The present invention relates to a method of producing a collagen membrane that has particular mechanical properties. In particular, the present invention relates to a method A of producing a collagen membrane comprising the steps of (i) isolating a collagen-containing tissue and incubating same in an ethanol solution; (ii) incubating the collagen-containing tissue from step (i) in a first solution comprising an inorganic salt and an anionic surfactant in order to denature non-collagenous proteins contained therein; (iii) incubating the collagen-containing tissue produced in step (ii) in a second solution comprising an inorganic acid until the collagen in said material is denatured; and (iv) incubating the collagen-containing tissue produced in step (iii) in a third solution comprising an inorganic acid with simultaneous mechanical stimulation for sufficient time to enable the collagen bundles in said collagen-containing tissue to align; wherein the mechanical stimulation comprises applying tension cyclically to the collagen-containing tissue.

IPC Classes  ?

• A61L 27/24 - Collagen
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/56 - Porous or cellular materials
• A61L 27/58 - Materials at least partially resorbable by the body
• C07K 1/113 - General processes for the preparation of peptides by chemical modification of precursor peptides without change of the primary structure
• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
• A61F 2/18 - Internal ear or nose parts, e.g. ear-drums

Abstract

in vitroScxScx).

IPC Classes  ?

• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• A61K 35/32 - BonesOsteocytesOsteoblastsTendonsTenocytesTeethOdontoblastsCartilageChondrocytesSynovial membrane
• C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes

Abstract

The invention pertains to the technical field of a method for isolating and expanding tendon cells in vitro. The invention also relates to cellular compositions comprising such tendon cells and use thereof to repair tendon tissue. In particular, the present invention relates to a cellular composition comprising isolated tendon cells which cells express tenomodulin (TNMD) and scleraxis (Scx).

IPC Classes  ?

• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• A61K 35/32 - BonesOsteocytesOsteoblastsTendonsTenocytesTeethOdontoblastsCartilageChondrocytesSynovial membrane

Abstract

There is disclosed a collagen construct comprising a plurality of elongate strips, wherein each strip contains a plurality of collagen fibres that are substantially aligned along the length of the respective strips, and the strips are braided or woven together to produce a collagen construct in the form of a rope that can be used for replacing tendons or ligaments, such as cruciate ligaments. Also disclosed is a method for making or producing the collagen construct from a collagen membrane having a plurality of collagen fibres being substantially aligned parallel to each other in a common direction. The membrane is cut along cut lines that are orientated substantially parallel to that common direction, thereby to separate elongate strips from the membrane. The strips are then braided or woven together to form the collagen construct.

IPC Classes  ?

• A61F 2/08 - MusclesTendonsLigaments
• A61L 27/24 - Collagen

Abstract

The subject invention relates generally to the repair of severed or damaged nerve and/or epineurium in a patient in need of such treatment. In particular, the present invention provides devices and methods of repairing severed or damaged nerve and/or epineurium. In some embodiments, a device is provided for the in vivo repair of severed or damaged nerve and/or epineurium comprising: a pliable collagen membrane comprising a first surface and a second surface, said first surface having a plurality of protruding collagen bundles and said second surface comprising a plurality of apertures, said apertures and said collagen bundles arranged to form a self-engaging attachment when said first surface and said second surface are placed together.

IPC Classes  ?

• A61B 17/00 - Surgical instruments, devices or methods
• A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
• A61B 50/30 - Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
• A61L 27/24 - Collagen

Goods & Services

Stem cells for medical purposes; collagen for medical use; biodegradable implants for use in guided tissue regeneration; implant materials for use in guided tissue regeneration in surgery; implantable materials for use in guided tissue regeneration; implants for guided tissue regeneration; surgical implants grown from stem cells (living tissues); therapeutic agents (medical); therapeutic biological products (medical); medical preparations; guided tissue regeneration materials; biological preparations for medical purposes; tissue-regenerative medical preparations; tissues for medical use; surgical dressings incorporating collagen; surgical dressings made from collagen; tissue-regenerative pharmaceutical preparations; tissues for surgical use; collagen based scaffolding for biomechanical support and stabilisation; collagen based ligament substitutes, including for use in acl reconstruction; none of the aforementioned goods being or in relation to genomics, sequencing of genomes, transcriptomes or epigenomes, medical diagnostic assays and reagents for use in genetic sequencing and biochemical analysis. Artificial orthopaedic implants; biodegradable bone fixation implants; dental implants; medical implants; orthopaedic implants; surgical implants (prosthesis) for use in human medicine; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for replacing human tissue; surgical implants comprised of artificial materials for use in guided tissue regeneration; surgical prostheses; artificial skin for surgical purposes; orthopaedic implants made of artificial materials; artificial materials for use in guided tissue regeneration; artificial replacement materials for human tissue; artificial replacement materials for animal tissue; artificial ligament substitutes, including for use in acl reconstruction.

Abstract

The invention relates to an artificial periosteum comprising a functionalized collagen-containing membrane and a drug-carrier mixture, wherein the drug-carrier mixture comprises at least one therapeutic agent and a calcium-containing carrier mixture. The invention also relates to use of the artificial periosteum for repairing bone.

IPC Classes  ?

• A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61K 38/18 - Growth factorsGrowth regulators

Abstract

The invention relates to a method of producing an implantable collagen-containing medical device comprising the step of coating said collagen-containing medical device with metal microparticles and/or metal nanoparticles, wherein said step of coating said collagen-containing medical device is by sonication such that the collagen-containing medical device has anti-bacterial and anti-inflammatory properties on implantation compared to the medical device not coated with metal microparticles and/or metal nanoparticles.

IPC Classes  ?

• A61L 27/24 - Collagen
• A61L 27/04 - Metals or alloys
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/58 - Materials at least partially resorbable by the body
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

Goods & Services

Stem cells for medical purposes; collagen for medical use; biodegradable implants comprising living tissue and collagen for use in guided tissue regeneration; implant materials for use in guided tissue regeneration in surgery, namely, implants comprising living tissue and collagen; implantable materials for use in guided tissue regeneration, namely, implants comprising living tissue and collagen; implants comprising living tissue and collagen for guided tissue regeneration; surgical implants comprising living tissue grown from stem cells; guided tissue regeneration materials, namely, biological tissue and collagen; biological preparations for medical purposes, namely, pharmaceutical preparations and substances for the treatment of damaged joints, tendons, ligaments, skin and tissue; tissues for medical use, namely, biological tissue grafts; surgical dressings incorporating collagen; surgical dressings made from collagen; tissue regenerative pharmaceutical preparations, namely, pharmaceutical preparations for regenerating tissue; tissues for surgical use, namely, implants comprising living tissue;, collagen based scaffolding for biomechanical support and stabilisation, namely, implantable scaffolds comprising living tissue and collagen for promoting integration of ligament into bone and ligamentisation; collagen based ligament substitutes, including for use in ACL construction being substitutes for ligaments comprising living tissue; none of the aforementioned goods being or in relation to genomics, sequencing of genomes, transcriptomes or epigenomes, medical diagnostic assays and reagents for use in genetic sequencing and biochemical analysis Artificial orthopaedic implants; biodegradable bone fixation implants; dental implants; medical implants made of artificial materials; orthopaedic implants made of artificial materials; surgical implants made of artificial materials for use in human medicine; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for replacing human tissue; surgical implants comprised of artificial materials for use in guided tissue regeneration; surgical prostheses, namely, joint, tendon and ligament prostheses; artificial skin for surgical purposes; artificial materials for use in guided tissue regeneration, namely, implants consisting of artificial materials; artificial replacement materials for human tissue, namely, human tissue grafts consisting of artificial materials; artificial replacement materials for animal tissue, namely, animal tissue grafts consisting of artificial materials; artificial ligament substitutes, including for use in ACL reconstruction

Abstract

The present invention relates to a sutureless method of repairing soft tissue defects in soft tissue including ligaments such as anterior cruciate ligaments (ACLs). In particular, the present invention relates a sutureless method of repairing soft tissue defect comprising: (i) providing a collagen-containing patch adapted to enclose at least a portion of said soft tissue defect; (ii) contacting said soft tissue defect and/or collagen-containing patch with a sensitizer; (Hi) enclosing said soft tissue defect in said collagen-containing patch to produce a bioactive chamber; and (iv) adhering said collagen-containing patch to said soft tissue defect without sutures.

IPC Classes  ?

• A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
• A61L 27/24 - Collagen
• A61L 27/50 - Materials characterised by their function or physical properties
• A61F 2/08 - MusclesTendonsLigaments
• A61L 27/58 - Materials at least partially resorbable by the body

Abstract

The present invention relates to methods for preparing bioscaffolds useful in the repair of tears. More specifically, the invention relates to a method of treating rotator cuff tear in a mammalian subject in need thereof comprising the steps of: (i) selectively expanding tenocytes in vitro in culture medium comprising insulin or a functional derivative and a glucocorticoid or a glucocorticoid-like molecule to produce a culture of expanded tenocytes; (ii) seeding a bioscaffold with said expanded tenocytes to produce a tenocyte seeded bioscaffold; and (iii) implanting said tenocyte seeded bioscaffold proximal to the rotator cuff tear. The present invention also relates to a bioscaffold comprising cells, wherein more than 80% of said cells are tenocytes.

IPC Classes  ?

• A61L 27/38 - Animal cells
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof

Goods & Services

Stem cells for medical purposes; collagen for medical use; biodegradable implants for use in guided tissue regeneration; implant materials for use in guided tissue regeneration in surgery; implantable materials for use in guided tissue regeneration; implants for guided tissue regeneration; surgical implants grown from stem cells (living tissues); therapeutic agents (medical); therapeutic biological products (medical); medical preparations; guided tissue regeneration materials; biological preparations for medical purposes; tissue-regenerative medical preparations; tissues for medical use; collagen based scaffolding for biomechanical support and stabilisation; cellular therapeutic tendon and cartilage regeneration products. Medical implants; orthopaedic implants; surgical implants comprised of artificial materials; dental implants; biodegradable bone fixation implants; surgical implants comprised of artificial materials for use in guided tissue regeneration; surgical implants comprised of artificial materials for replacing human tissue; surgical prostheses; artificial skin for surgical purposes; surgical implants (prosthesis) for use in human medicine; orthopaedic materials; artificial orthopaedic implants; artificial materials for use in guided tissue regeneration; artificial replacement materials for human tissue; surgical implants comprised of artificial materials for replacing animal and human tissue. Advisory services relating to medical services; medical services; medical advisory services; medical care services; medical health assessment services; medical treatment services; provision of medical information; provision of medical services; therapy services; physical therapy; medical services, including those relating to biomechanical and cellular therapeutic medical techniques.

Goods & Services

Stem cells for medical purposes; collagen for medical use; biodegradable implants for use in guided tissue regeneration; implant materials for use in guided tissue regeneration in surgery; implantable materials for use in guided tissue regeneration; implants for guided tissue regeneration; surgical implants grown from stem cells (living tissues); therapeutic agents (medical); therapeutic biological products (medical); medical preparations; guided tissue regeneration materials; biological preparations for medical purposes; tissue-regenerative medical preparations; tissues for medical use; surgical dressings incorporating collagen; surgical dressings made from collagen; tissue-regenerative pharmaceutical preparations; tissues for surgical use. Artificial orthopaedic implants; biodegradable bone fixation implants; dental implants; medical implants; orthopaedic implants; surgical implants (prosthesis) for use in human medicine; surgical implants comprised of artificial materials; surgical implants comprised of artificial materials for replacing human tissue; surgical implants comprised of artificial materials for use in guided tissue regeneration; surgical prostheses; artificial skin for surgical purposes; orthopaedic materials; artificial materials for use in guided tissue regeneration; artificial replacement materials for human tissue; replacement materials for animal tissue.

Goods & Services

Stem cells for medical purposes; collagen for medical use; biodegradable implants for use in guided tissue regeneration; implant materials for use in guided tissue regeneration in surgery; implantable materials for use in guided tissue regeneration; implants for guided tissue regeneration; surgical implants grown from stem cells (living tissues); therapeutic agents (medical); therapeutic biological products (medical); medical preparations; guided tissue regeneration materials; biological preparations for medical purposes; tissue-regenerative medical preparations; tissues for medical use; collagen based scaffolding for biomechanical support and stabilisation; cellular therapeutic tendon and cartilage regeneration products. Medical implants; orthopaedic implants; surgical implants comprised of artificial materials; dental implants; biodegradable bone fixation implants; surgical implants comprised of artificial materials for use in guided tissue regeneration; surgical implants comprised of artificial materials for replacing human tissue; surgical prostheses; artificial skin for surgical purposes; surgical implants (prosthesis) for use in human medicine; orthopaedic materials; artificial orthopaedic implants; artificial materials for use in guided tissue regeneration; artificial replacement materials for human tissue; replacement materials for animal and human tissue. Advisory services relating to medical services; medical services; medical advisory services; medical care services; medical health assessment services; medical treatment services; provision of medical information; provision of medical services; therapy services; physical therapy; medical services, including those relating to biomechanical and cellular therapeutic medical techniques.

Goods & Services

Stem cells for medical purposes; collagen for medical use; biodegradable implants being implantable scaffolds comprising biological materials, namely, living cells for use in guided tissue regeneration; surgical implant materials being implantable scaffolds comprising biological materials, namely, living cells for use in guided tissue regeneration; implantable materials being implantable scaffolds comprising biological materials, namely, living cells for use in guided tissue regeneration; implants being implantable scaffolds comprising biological materials, namely, living cells for use in guided tissue regeneration; surgical implants comprised of living tissues; therapeutic agents for tissue regeneration; therapeutic biological products, namely, biological cell cultures for medical purposes; medical preparations, namely, medical preparations for tissue regeneration; guided tissue regeneration materials, namely, materials for the regeneration of bone and soft tissue, namely, living tissue and nerve tissue; biological preparations for medical purposes for use in guided tissue regeneration for tissue repair; tissue-regenerative medical preparations for use in regeneration of damaged bone and soft tissue, namely, living tissue and nerve tissue; tissues for medical use being living cells and implantable scaffolds comprising biological materials; surgical dressings incorporating collagen; surgical dressings made from collagen; tissue-regenerative pharmaceutical preparations for use in regeneration of damaged bone and soft tissue, namely, living tissue and nerve tissue; tissues for surgical use, namely, for use in regeneration of damaged bone and soft tissue, namely, living tissue and nerve tissue Artificial orthopaedic implants; biodegradable bone fixation implants made of artificial materials and non-living biological materials; dental implants made of artificial materials and non-living biological materials; medical implants, namely, implants made from artificial biomaterials, namely, synthetic collagen, for use in the regeneration of bone and soft tissue, and nerve tissue; orthopaedic implants, namely, implants made from artificial biomaterials for use in the regeneration of bone and soft tissue, and nerve tissue; surgical implants prosthesis made of artificial materials and non-living biological materials for use in human medicine; surgical implants comprised of artificial materials and non-living biological materials; surgical implants comprised of artificial materials and non-living biological materials for replacing human tissue; surgical implants comprised of artificial materials and non-living biological materials for use in guided tissue regeneration; surgical prostheses, namely, implantable scaffolds comprising artificial materials and non-living biological materials for the regeneration of bone and soft tissue, and nerve tissue; artificial skin for surgical purposes; orthopaedic materials, namely, orthopaedic materials made from artificial biomaterials for use in the regeneration of bone and soft tissue, and nerve tissue; artificial materials and non-living biological materials for use in guided tissue regeneration, namely, implantable scaffolds comprising artificial biomaterials for the regeneration of bone and soft tissue, and nerve tissue; artificial replacement materials for human tissue, namely, synthetic collagen based scaffolding materials; replacement materials for animal tissue, namely, synthetic collagen based scaffolding materials

Goods & Services

Stem cells for medical purposes; collagen for medical use; biodegradable implants being living cells or implantable scaffolds comprising biological materials for use in guided tissue regeneration; surgical implant materials being living cells or implantable scaffolds comprising biological materials for use in guided tissue regeneration; implantable materials being living cells or implantable scaffolds comprising biological materials for use in guided tissue regeneration; implants being living cells or implantable scaffolds comprising biological materials for use in guided tissue regeneration; surgical implants comprised of living tissues; medical therapeutic agents for tissue regeneration; medical therapeutic biological products, namely, biological cell cultures for medical purposes; medical preparations, namely, medical preparations for tissue regeneration; guided tissue regeneration materials, namely, materials for the regeneration of bone and soft tissue, namely, living tissue and nerve tissue; biological preparations for medical purposes for use in guided tissue regeneration for tissue repair; tissue-regenerative medical preparations for use in regeneration of damaged bone and soft tissue, namely, living tissue and nerve tissue; tissues for medical use being living cells; collagen based scaffolding for biomechanical support and stabilization, namely, implantable scaffolds comprising biological materials; cellular therapeutic tendon and cartilage regeneration products, namely, living cells or implantable scaffolds comprising biological materials Medical implants, namely, implants made from artificial biomaterials, namely, synthetic collagen, for use in the regeneration of bone and soft tissue, and nerve tissue; orthopaedic implants, namely, implants made from artificial biomaterials for use in the regeneration of bone and soft tissue, and nerve tissue; surgical implants comprised of artificial materials; dental implants made of artificial materials; biodegradable bone fixation implants made of artificial materials; surgical implants comprised of artificial materials for use in guided tissue regeneration; surgical implants comprised of artificial materials for replacing human tissue; surgical prostheses, namely, implantable scaffolds comprising artificial materials for the regeneration of bone and soft tissue and nerve tissue; artificial skin for surgical purposes; surgical prosthesis implants made of artificial materials for use in human medicine; orthopaedic materials, namely, orthopaedic materials made from artificial biomaterials for use in the regeneration of bone and soft tissue, and nerve tissue; artificial orthopaedic implants; artificial materials for use in guided tissue regeneration, namely, implantable scaffolds comprising artificial biomaterials for the regeneration of bone and soft tissue, and nerve tissue; artificial replacement materials for human tissue, namely, synthetic collagen based scaffolding materials; surgical implants comprised of artificial materials for replacing animal and human tissue Advisory services relating to medical services namely providing advice in the field of bone and soft tissue regeneration; medical services; medical advisory services; medical care services for the regeneration of bone and soft tissue; medical health assessment services; medical treatment services for the regeneration of bone and soft tissue; provision of medical information; provision of medical services; therapy services for the regeneration of bone and soft tissue; physical therapy; medical services, including those relating to biomechanical and cellular therapeutic medical techniques

Goods & Services

Stem cells for medical purposes; collagen for medical use; surgical biodegradable implants being living cells and implantable scaffolds comprising biological materials for use in guided tissue regeneration; surgical implant materials being living cells and implantable scaffolds comprising biological materials for use in guided tissue regeneration; surgical implantable materials being living cells and implantable scaffolds comprising biological materials for use in guided tissue regeneration; surgical implants comprised of living tissues; therapeutic agents for tissue regeneration; therapeutic biological products namely biological cell cultures for medical purposes; medical preparations namely medical preparations for tissue regeneration; guided tissue regeneration materials namely materials for the regeneration of bone and soft tissue; biological preparations for medical purposes for use in guided tissue regeneration for tissue repair; tissue-regenerative medical preparations for use in regeneration of damaged bone tissue; tissues for medical use being living cells; implantable collagen based scaffolding comprising biologically derived collagen for biomechanical support and stabilisation; cellular therapeutic tendon and cartilage regeneration products, namely, preparations comprising cells for the regeneration of bone and soft tissue Medical implants made of artificial materials; orthopaedic implants made of artificial materials; surgical implants comprised of artificial materials; dental implants; biodegradable bone fixation implants; surgical implants comprised of artificial materials for use in guided tissue regeneration; surgical implants comprised of artificial materials for replacing human tissue; surgical prostheses namely surgical prostheses for replacing bone and soft tissue; artificial skin for surgical purposes; surgical implants for use in human medicine in the nature of implants made of synthetic materials for use in the regeneration of bone and soft tissue; orthopaedic materials namely synthetic materials for use in the regeneration of bone and soft tissue; orthopaedic implants made of artificial materials; artificial materials for use in guided tissue regeneration namely implantable scaffolds comprising artificial materials for the regeneration of bone and tissue; artificial replacement materials for human tissue namely synthetic collagen based scaffolding materials; replacement materials for animal and human tissue namely synthetic collagen based materials Advisory services relating to medical services; medical services; medical health assessment services; provision of medical information; therapy services being cellular therapy services for the regeneration of bone and soft tissue; physical therapy; medical services featuring biomechanical and cellular therapeutic medical techniques

Goods & Services

Stem cells for medical purposes; collagen for medical use; biodegradable implants for use in guided tissue regeneration; implant materials for use in guided tissue regeneration in surgery; implantable materials for use in guided tissue regeneration; implants for guided tissue regeneration; surgical implants grown from stem cells (living tissues); therapeutic agents (medical); therapeutic biological products (medical); medical preparations; guided tissue regeneration materials; biological preparations for medical purposes; tissue-regenerative medical preparations; tissues for medical use. Medical research; scientific and technological services; scientific research relating to biology. Advisory services relating to medical services; medical services; provision of medical services; medical advisory services; medical care services; medical health assessment services; medical treatment services; provision of medical information; therapy services; physical therapy.

Goods & Services

Stem cells for medical purposes; collagen for medical use; biodegradable surgical implants being living cells and implantable scaffolds comprising biological materials for use in guided tissue regeneration; surgical implant materials being living cells and implantable scaffolds comprising biological materials for use in guided tissue regeneration; surgical implantable materials being living cells and implantable scaffolds comprising biological materials for use in guided tissue regeneration; surgical implants comprised of living tissues; therapeutic agents for tissue regeneration; therapeutic biological products namely biological cell cultures for medical purposes; medical preparations namely medical preparations for tissue regeneration; guided tissue regeneration materials namely materials for the regeneration of bone and soft tissue; biological preparations for medical purposes for use in guided tissue regeneration for tissue repair; tissue-regenerative medical preparations for use in regeneration of damaged bone tissue; tissues for medical use being living cells Medical research; scientific and technological services, namely, research, testing and development of new tissue regeneration products and techniques in the field of biomechanical and cellular therapeutic medical techniques; scientific research in the field of biology Advisory services relating to medical services; medical services; medical health assessment services; provision of medical information; therapy services being cellular therapy services for the regeneration of bone and soft tissue; physical therapy

Goods & Services

(1) Collagen based scaffolding for biomechanical support and stabilisation; cellular therapeutic tendon and cartilage regeneration products (1) Scientific and technological research and design services relating to biomechanical and cellular therapeutic medical techniques (2) Medical services relating to biomechanical and cellular therapeutic medical techniques in the field of bone and soft tissue regeneration, namely, the provision of cell therapies using tendon-derived cells for the treatment of chronic degenerative tendon injuries

Abstract

There is disclosed a collagen construct comprising a plurality of elongate strips, wherein each strip contains a plurality of collagen fibres that are substantially aligned along the length of the respective strips, and the strips are braided or woven together to produce a collagen construct in the form of a rope that can be used for replacing tendons or ligaments, such as cruciate ligaments. Also disclosed is a method for making or producing the collagen construct from a collagen membrane having a plurality of collagen fibres being substantially aligned parallel to each other in a common direction. The membrane is cut along cut lines that are orientated substantially parallel to that common direction, thereby to separate elongate strips from the membrane. The strips are then braided or woven together to form the collagen construct.

IPC Classes  ?

• A61F 2/08 - MusclesTendonsLigaments
• A61L 27/24 - Collagen
• A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

Abstract

The present disclosure provides a medical procedure kit for ameliorating tissue damage in a patient, the kit comprising a container enclosing a receptacle, an extractor for extracting biological material including autologous cells from the patient, a strainer for straining autologous cells from the biological material and an implantable support having a surface onto which the autologous cells can adhere, the implantable support configured to be received by the receptacle. Also disclosed are related methods of manufacturing a medical material and using the medical procedure kit.

IPC Classes  ?

• A61B 10/02 - Instruments for taking cell samples or for biopsy
• A61L 27/24 - Collagen
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof

Abstract

The invention relates to an artificial periosteum comprising a functionalized collagen-containing membrane and a drug-carrier mixture, wherein the drug-carrier mixture comprises at least one therapeutic agent and a calcium-containing carrier mixture. The invention also relates to use of the artificial periosteum for repairing bone.

IPC Classes  ?

• A61K 9/70 - Web, sheet or filament bases
• A61L 27/00 - Materials for prostheses or for coating prostheses

Abstract

The invention relates to a method of producing an implantable collagen-containing medical device comprising the step of coating said collagen-containing medical device with metal microparticles and/or metal nanoparticles, wherein said step of coating said collagen-containing medical device is by sonication such that the collagen-containing medical device has anti-bacterial and anti-inflammatory properties on implantation compared to the medical device not coated with metal microparticles and/or metal nanoparticles.

IPC Classes  ?

• A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
• B01J 19/10 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing sonic or ultrasonic vibrations
• A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

Abstract

The present invention relates to a method of producing a collagen membrane that has particular mechanical properties. In particular, the present invention relates to a method A of producing a collagen membrane comprising the steps of (i) isolating a collagen-containing tissue and incubating same in an ethanol solution; (ii) incubating the collagen-containing tissue from step (i) in a first solution comprising an inorganic salt and an anionic surfactant in order to denature non-collagenous proteins contained therein; (iii) incubating the collagen-containing tissue produced in step (ii) in a second solution comprising an inorganic acid until the collagen in said material is denatured; and (iv) incubating the collagen-containing tissue produced in step (iii) in a third solution comprising an inorganic acid with simultaneous mechanical stimulation for sufficient time to enable the collagen bundles in said collagen-containing tissue to align; wherein the mechanical stimulation comprises applying tension cyclically to the collagen-containing tissue.

IPC Classes  ?

• A61L 27/24 - Collagen
• A61L 15/32 - Proteins, polypeptidesDegradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
• C07K 1/113 - General processes for the preparation of peptides by chemical modification of precursor peptides without change of the primary structure
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/56 - Porous or cellular materials
• A61L 27/58 - Materials at least partially resorbable by the body
• A61K 38/00 - Medicinal preparations containing peptides
• A61F 2/18 - Internal ear or nose parts, e.g. ear-drums

Goods & Services

Stem cells for medical purposes; medical preparations; guided tissue regeneration materials; biological preparations for medical purposes; tissue-regenerative medical preparations; tissues for medical use; materials for dental treatment; materials for making dental restorations; dental repair materials; dental restorative materials; surgical implants grown from stem cells (living tissues); collagen for medical use; biodegradable implants for use in guided tissue regeneration; implant materials for use in guided tissue regeneration in surgery; implantable materials for use in guided tissue regeneration; implants for guided tissue regeneration; therapeutic agents (medical); therapeutic biological products (medical); none of the aforementioned goods being or in relation to medical diagnostic assays and reagents for use in genetic sequencing and biochemical analysis, other than for research purposes. Medical research; scientific and technological services; scientific research relating to biology. Advisory services relating to medical services; physical therapy; medical services; medical advisory services; medical care services; medical health assessment services; medical treatment services; provision of medical information; provision of medical services; therapy services.

Goods & Services

Stem cells for medical purposes; medical preparations; guided tissue regeneration materials; biological preparations for medical purposes; tissue-regenerative medical preparations; tissues for medical use; surgical implants grown from stem cells (living tissues); collagen for medical use; biodegradable implants for use in guided tissue regeneration; implant materials for use in guided tissue regeneration in surgery; implantable materials for use in guided tissue regeneration; implants for guided tissue regeneration; therapeutic agents (medical); therapeutic biological products (medical). Medical research; scientific and technological services; scientific research relating to biology. Advisory services relating to medical services; physical therapy; medical services; medical advisory services; medical care services; medical health assessment services; medical treatment services; provision of medical information; provision of medical services; therapy services.

Goods & Services

Collagen based scaffolding for biomechanical support and stabilisation; cellular therapeutic tendon and cartilage regeneration products. Scientific and technological research and design services relating to biomechanical and cellular therapeutic medical techniques. Medical services, including those relating to biomechanical and cellular therapeutic medical techniques.

Goods & Services

Stem cells for medical purposes; medical preparations for use in connection with the regeneration of bone and soft tissue; guided tissue regeneration materials, namely, medical preparations for use in connection with the regeneration of bone and soft tissue; biological preparations for medical purposes, namely, for the regeneration of bone and soft tissue; tissue-regenerative medical preparations, namely, for use in connection with the regeneration of bone and soft tissue; medical preparations in the nature of tissues for medical use, namely, for use in connection with the regeneration of bone and soft tissue; surgical implants grown from stem cells comprised of living tissues for use in connection with the regeneration of bone and soft tissue; collagen for medical use; medical preparations in the nature of biodegradable implants for use in guided tissue regeneration, namely, for use in connection with the regeneration of bone and soft tissue; medical preparations in the nature of implant materials for use in guided tissue regeneration in surgery, namely, for use in connection with the regeneration of bone and soft tissue; medical preparations in the nature of implantable materials for use in guided tissue regeneration, namely, for use in connection with the regeneration of bone and soft tissue; medical preparations in the nature of implants for guided tissue regeneration, namely, for use in connection with the regeneration of bone and soft tissue; therapeutic agents for medical purposes, namely, for the regeneration of bone and soft tissue; therapeutic biological tissue cultures for medical purposes, namely, for the regeneration of bone and soft tissue Medical research; scientific research and technological research services; scientific research relating to biology; all the foregoing in the field of the regeneration of bone and soft tissue and biomechanical and cellular therapeutic medical techniques Advisory services relating to medical services; physical therapy; medical services; medical advisory services; medical care services; medical health assessment services; medical treatment services for the regeneration of bone and soft tissue; provision of medical information; provision of medical therapy services; all the foregoing in the field of the regeneration of bone and soft tissue and biomechanical and cellular therapeutic medical techniques, namely, all related to the provision of therapies involving the surgical implantation of cellular scaffold matrices

Goods & Services

Stem cells for medical purposes for regeneration of bone and soft tissue; medical preparations for use in connection with the regeneration of bone and soft tissue; guided tissue regeneration materials, namely, medical preparations for use in connection with the regeneration of bone and soft tissue; biological preparations for medical purposes, namely, for the regeneration of bone and soft tissue; tissue-regenerative medical preparations, namely, for use in connection with the regeneration of bone and soft tissue; medical preparations in the nature of tissues for medical use, namely, for use in connection with the regeneration of bone and soft tissue; materials for dental treatment, namely, dental preparations for use in connection with the regeneration of dental tissue; materials for making dental restorations, namely, dental preparations for use in connection with the regeneration of dental tissue; dental repair materials, namely, dental preparations for use in connection with the regeneration of dental tissue; dental restorative materials, namely, dental preparations for use in connection with the regeneration of dental tissue; surgical implants, namely, living tissues grown from stem cells for use in connection with the regeneration of bone and soft tissue; collagen for medical use; medical preparations in the nature of biodegradable implants for use in guided tissue regeneration, namely, for use in connection with the regeneration of bone and soft tissue; medical preparations in the nature of implant materials for use in guided tissue regeneration in surgery, namely, for use in connection with the regeneration of bone and soft tissue; medical preparations in the nature of implantable materials for use in guided tissue regeneration, namely, for use in connection with the regeneration of bone and soft tissue; medical preparations in the nature of implants for guided tissue regeneration, namely, for use in connection with the regeneration of bone and soft tissue; therapeutic agents for medical purposes, namely, for the regeneration of bone and soft tissue; therapeutic biological tissue cultures for medical purposes, namely, for the regeneration of bone and soft tissue; none of the aforementioned goods being or in relation to genomics, sequencing of genomes, transcriptomes or epigenomes, medical diagnostic assays and reagents for use in genetic sequencing and biochemical analysis Scientific and technological research services in the field of biomechanical and cellular therapeutic medical techniques and design services, namely, design of new tissue and bone regeneration products and techniques related to biomechanical and cellular therapeutic techniques Advisory services relating to medical services; physical therapy; medical services; medical advisory services; medical care services; medical health assessment services; medical treatment services for the regeneration of bone and soft tissue; provision of medical information; provision of medical services for the regeneration of bone and soft tissue; physical therapy services; all of the foregoing related to regeneration of bone and soft tissues and biomechanical and cellular therapeutic techniques

Goods & Services

Stem cells for medical purposes; medical preparations; guided tissue regeneration materials; biological preparations for medical purposes; tissue-regenerative medical preparations; tissues for medical use; materials for dental treatment; materials for making dental restorations; dental repair materials; dental restorative materials; surgical implants grown from stem cells (living tissues); collagen for medical use; biodegradable implants for use in guided tissue regeneration; implant materials for use in guided tissue regeneration in surgery; implantable materials for use in guided tissue regeneration; implants for guided tissue regeneration; therapeutic agents (medical); therapeutic biological products (medical); none of the aforementioned goods being or in relation to medical diagnostic assays and reagents for use in genetic sequencing and biochemical analysis, other than for research purposes. Medical research; scientific and technological services; scientific research relating to biology. Advisory services relating to medical services; physical therapy; medical services; medical advisory services; medical care services; medical health assessment services; medical treatment services; provision of medical information; provision of medical services; therapy services.

Goods & Services

Cellular therapeutic tendon and cartilage regeneration products, namely, medicaments to help assist with the regeneration of tendon, nerve and cartilage tissue

Goods & Services

Scientific and technological research and design services relating to biomechanical and cellular therapeutic medical techniques in the field of the regeneration of bone and soft tissue, namely research and design services relating to cell therapies for the treatment of chronic degenerative tendon injuries Medical services, including those relating to biomechanical and cellular therapeutic medical techniques in the field of regeneration of bone and soft tissue, namely the provision of cell therapies using tendon derived cells for the treatment of chronic degenerative tendon injuries

Abstract

The present disclosure provides a medical procedure kit for ameliorating tissue damage in a patient, the kit comprising a container enclosing a receptacle, an extractor for extracting biological material including autologous cells from the patient, a strainer for straining autologous cells from the biological material and an implantable support having a surface onto which the autologous cells can adhere, the implantable support configured to be received by the receptacle. Also disclosed are related methods of manufacturing a medical material and using the medical procedure kit.

IPC Classes  ?

• A61B 10/02 - Instruments for taking cell samples or for biopsy

Goods & Services

Stem cells for medical purposes; collagen for medical use; biodegradable implants for use in guided tissue regeneration; implant materials for use in guided tissue regeneration in surgery; implantable materials for use in guided tissue regeneration; implants for guided tissue regeneration; surgical implants grown from stem cells (living tissues); therapeutic agents (medical); therapeutic biological products (medical); medical preparations; guided tissue regeneration materials; biological preparations for medical purposes; tissue-regenerative medical preparations; tissues for medical use; collagen based scaffolding for biomechanical support and stabilisation; cellular therapeutic tendon and cartilage regeneration products. Medical research; scientific and technological services; scientific research relating to biology; scientific and technological research and design services relating to biomechanical and cellular therapeutic medical techniques. Advisory services relating to medical services; medical services; medical advisory services; medical care services; medical health assessment services; medical treatment services; provision of medical information; provision of medical services; therapy services; physical therapy; medical services, including those relating to biomechanical and cellular therapeutic medical techniques.

Goods & Services

Stem cells for medical purposes; collagen for medical use; biodegradable implants comprising biological material being living cells and implantable scaffolds comprising biological materials for use in guided tissue regeneration; implant materials comprising biological material being living cells and implantable scaffolds comprising biological materials for use in guided tissue regeneration in surgery; implantable materials comprising biological material being living cells and implantable scaffolds comprising biological materials for use in guided tissue regeneration; implants comprising biological material being living cells and implantable scaffolds comprising biological materials for guided tissue regeneration; surgical implants comprised of living cells; therapeutic agents, namely, therapeutic agents for tissue regeneration; therapeutic biological products, namely, biological cell cultures for medical purposes, Biological tissue grafts, Biological preparations for guided tissue regeneration; medical preparations for the treatment of tissue repair; guided tissue regeneration materials, namely, implants comprising biological materials being living cells and implantable scaffolds comprising biological materials; biological preparations for medical purposes for use in guided tissue regeneration for tissue repair; tissue-regenerative medical preparations for use in guided tissue regeneration of damaged tissue; biological materials for medical use, namely, surgical implants comprised of living cells, Biological tissue grafts, Biological materials for medical purposes being living cells and implantable scaffolds comprising biological materials; Collagen for medical purposes, namely, collagen based scaffolding for biomechanical support and stabilisation; Cells for medical or clinical use, namely, cellular therapeutic tendon and cartilage regeneration products Medical research; scientific and technological services, namely, product research and development relating to tissue regeneration products and techniques in the field of biomechanical and cellular therapeutic medical techniques; scientific research relating to biology; scientific and technological research and design services relating to biomechanical and cellular therapeutic medical techniques Advisory services relating to medical services; medical services; medical advisory services; medical care services; medical health assessment services; medical treatment services of regeneration of damaged tissue and for tissue repair; provision of medical information; provision of medical services; medical services, including those relating to biomechanical and cellular therapeutic medical techniques

Abstract

There is disclosed a collagen construct comprising a plurality of elongate strips, wherein each strip contains a plurality of collagen fibres that are substantially aligned along the length of the respective strips, and the strips are braided or woven together to produce a collagen construct in the form of a rope that can be used for replacing tendons or ligaments, such as cruciate ligaments. Also disclosed is a method for making or producing the collagen construct from a collagen membrane having a plurality of collagen fibres being substantially aligned parallel to each other in a common direction. The membrane is cut along cut lines that are orientated substantially parallel to that common direction, thereby to separate elongate strips from the membrane. The strips are then braided or woven together to form the collagen construct.

IPC Classes  ?

• A61F 2/08 - MusclesTendonsLigaments
• A61L 27/24 - Collagen
• A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

Goods & Services

Collagen based scaffolding for biomechanical support and stabilisation of bone and soft tissue; cellular therapeutic tendon and cartilage regeneration materials. Scientific and technological research and design services relating to biomechanical and cellular therapeutic medical techniques. Medical services, including those relating to biomechanical and cellular therapeutic medical techniques.

Goods & Services

Collagen based scaffolding for biomechanical support and stabilisation of bone and soft tissue; cellular therapeutic tendon and cartilage regeneration materials. Scientific and technological research and design services relating to biomechanical and cellular therapeutic medical techniques. Medical services, including those relating to biomechanical and cellular therapeutic medical techniques.

Goods & Services

Collagen for medical purposes, namely, collagen based scaffolding for biomechanical support and stabilisation of bone and soft tissue; cellular therapeutic tendon and cartilage regeneration materials, namely, medicaments to help assist with the regeneration of tendon and cartilage tissue Scientific and technological research in the field of biomechanical and cellular therapeutic medical techniques, and design services, namely, design of new tissue and bone regeneration products and techniques relating to biomechanical and cellular therapeutic techniques

Abstract

A medical composition is disclosed, which is injectable and which comprises a mixture of native components, which are obtainable by culturing one or more cell samples from a human or animal during normal conditions, said native components being included in the group consisting of growth factors, extracellular matrix proteins, and other substances produced by said cell samples during normal conditions, and a pharmaceutically acceptable carrier, as well as a method for producing the native components, a method for producing the medical composition, a method for treating a subject in need of tissue repair by injection of the medical composition, and use of said mixture of native components for the production of said medical composition for tissue repair via injection. A medical composition is disclosed, which is injectable and which comprises a mixture of native components, which are obtainable by culturing one or more cell samples from a human or animal during normal conditions, said native components being included in the group consisting of growth factors, extracellular matrix proteins, and other substances produced by said cell samples during normal conditions, and a pharmaceutically acceptable carrier, as well as a method for producing the native components, a method for producing the medical composition, a method for treating a subject in need of tissue repair by injection of the medical composition, and use of said mixture of native components for the production of said medical composition for tissue repair via injection.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/02 - Propagation of single cells or cells in suspensionMaintenance thereofCulture media therefor
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 38/18 - Growth factorsGrowth regulators
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61K 38/30 - Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
• A61K 38/39 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• A61L 15/18 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells

Abstract

There is disclosed a collagen construct comprising a plurality of elongate strips, wherein each strip contains a plurality of collagen fibres that are substantially aligned along the length of the respective strips, and the strips are braided or woven together to produce a collagen construct in the form of a rope that can be used for replacing tendons or ligaments, such as cruciate ligaments. Also disclosed is a method for making or producing the collagen construct from a collagen membrane having a plurality of collagen fibres being substantially aligned parallel to each other in a common direction. The membrane is cut along cut lines that are orientated substantially parallel to that common direction, thereby to separate elongate strips from the membrane. The strips are then braided or woven together to form the collagen construct.

IPC Classes  ?

• A61L 27/24 - Collagen
• A61F 2/08 - MusclesTendonsLigaments

Abstract

The present invention relates to a sutureless method of repairing soft tissue defects in soft tissue including ligaments such as anterior cruciate ligaments (ACLs). Jn particular, the present invention relates a sutureless method of repairing soft tissue defect comprising: (i) providing a collagen-containing patch adapted to enclose at least a portion of said soft tissue defect; (ii) contacting said soft tissue defect and/or collagen-containing patch with a sensitizer; (Hi) enclosing said soft tissue defect in said collagen-containing patch to produce a bioactivc chamber; and (iv) adhering said collagen-containing patch to said soft tissue defect without sutures.

IPC Classes  ?

• A61L 15/32 - Proteins, polypeptidesDegradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
• A61L 27/58 - Materials at least partially resorbable by the body
• A61F 2/08 - MusclesTendonsLigaments

Abstract

The present invention relates to a method of producing a collagen membrane that has particular mechanical properties. In particular, the present invention relates to a method A of producing a collagen membrane comprising the steps of (i) isolating a collagen-containing tissue and incubating same in an ethanol solution; (ii) incubating the collagen-containing tissue from step (i) in a first solution comprising an inorganic salt and an anionic surfactant in order to denature non-collagenous proteins contained therein; (iii) incubating the collagen-containing tissue produced in step (ii) in a second solution comprising an inorganic acid until the collagen in said material is denatured; and (iv) incubating the collagen-containing tissue produced in step (iii) in a third solution comprising an inorganic acid with simultaneous mechanical stimulation for sufficient time to enable the collagen bundles in said collagen-containing tissue to align; wherein the mechanical stimulation comprises applying tension cyclically to the collagen-containing tissue.

IPC Classes  ?

• A61K 38/39 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• A61L 27/24 - Collagen
• C07K 1/113 - General processes for the preparation of peptides by chemical modification of precursor peptides without change of the primary structure
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
• A61L 27/56 - Porous or cellular materials
• A61L 27/58 - Materials at least partially resorbable by the body
• A61K 38/00 - Medicinal preparations containing peptides
• A61F 2/18 - Internal ear or nose parts, e.g. ear-drums

Abstract

The present invention relates to a method of producing a collagen membrane that has particular mechanical properties. In particular, the present invention relates to a method A of producing a collagen membrane comprising the steps of (i) isolating a collagen-containing tissue and incubating same in an ethanol solution; (ii) incubating the collagen-containing tissue from step (i) in a first solution comprising an inorganic salt and an anionic surfactant in order to denature non-collagenous proteins contained therein; (iii) incubating the collagen- containing tissue produced in step (ii) in a second solution comprising an inorganic acid until the collagen in said material is denatured; and (iv) incubating the collagen-containing tissue produced in step (iii) in a third solution comprising an inorganic acid with simultaneous mechanical stimulation for sufficient time to enable the collagen bundles in said collagen- containing tissue to align; wherein the mechanical stimulation comprises applying tension cyclically to the collagen-containing tissue.

IPC Classes  ?

• A61L 27/24 - Collagen
• A61F 2/18 - Internal ear or nose parts, e.g. ear-drums

Abstract

A medical composition is disclosed, which is injectable and which comprises a mixture of native components, which are obtainable by culturing one or more cell samples from a human or animal during normal conditions, said native components being included in the group consisting of growth factors, extracellular matrix proteins, and other substances produced by said cell samples during normal conditions, and a pharmaceutically acceptable carrier, as well as a method for producing the native components, a method for producing the medical composition, a method for treating a subject in need of tissue repair by injection of the medical composition, and use of said mixture of native components for the production of said medical composition for tissue repair via injection. A medical composition is disclosed, which is injectable and which comprises a mixture of native components, which are obtainable by culturing one or more cell samples from a human or animal during normal conditions, said native components being included in the group consisting of growth factors, extracellular matrix proteins, and other substances produced by said cell samples during normal conditions, and a pharmaceutically acceptable carrier, as well as a method for producing the native components, a method for producing the medical composition, a method for treating a subject in need of tissue repair by injection of the medical composition, and use of said mixture of native components for the production of said medical composition for tissue repair via injection.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/02 - Propagation of single cells or cells in suspensionMaintenance thereofCulture media therefor
• C12N 5/07 - Animal cells or tissues
• A61L 15/18 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
• A61K 38/30 - Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
• A61K 38/39 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61K 38/18 - Growth factorsGrowth regulators

Abstract

The present invention relates to a method for culturing tenocytes. In particular the present invention relates to a method for culturing tenocytes comprising the step of incubating tenocytes in a culture medium comprising insulin or functional derivative.

IPC Classes  ?

• A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/02 - Propagation of single cells or cells in suspensionMaintenance thereofCulture media therefor