CARTRIDGE FOR PRE-PURIFYING A SAMPLE OF RADIOLABELLED COMPOUNDS WITH A VIEW TO PURIFYING SAME BY HIGH-PRESSURE CHROMATOGRAPHY, PRE-PURIFICATION AND INJECTION DEVICE, AND PRE-PURIFICATION AND INJECTION METHOD
Provided is a cartridge for the pre-purification of a liquid sample comprising radiolabelled compounds intended to be purified via high-pressure chromatography, comprising a casing filtration means, a chamber comprising a solid stationary phase and fluid communication means; the casing and the fluid communication means being capable of mechanically withstanding a fluid pressure greater than or equal to 50 bars. Also provided is a pre-purification and injection device integrating said cartridge and a pre-purification and injection method using said cartridge.
A collection system for recovering a separated radioactive fraction, comprising: a collection inlet configured to receive a fraction from a separation system, a radio detector configured to determine the radioactivity of the fraction and generate a radiodetection signal based on the determined radioactivity, a collection valve system in fluid communication with the collection inlet, wherein the collection valve system comprises at least one or more of the collection vessel outlets and a waste outlet, a control unit configured to control the collection valve system to guide the fraction to one of the collection vessel outlets or a waste outlet.
A method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, which method includes carrying out a first synthesis run comprising the steps of: a) providing water containing 18F; b) trapping the 18F from the water provided in step a) on an anion exchange material; c) eluting the trapped 18F from the anion exchange material to a reaction vessel of first radiopharmaceutical synthesis cassette; d) preparing a radiopharmaceutical incorporating the eluted 18F using the first radiopharmaceutical synthesis cassette; where steps a)-d) are repeated in at least one subsequent run using another radiopharmaceutical synthesis cassette; and where the method includes a reconditioning step of treating the anion exchange material with water between two consecutive runs. Other aspects of the invention relate to a device for performing this method, and a cassette for use in the device.
C07H 5/02 - Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
C07B 59/00 - Introduction of isotopes of elements into organic compounds
B01J 19/24 - Stationary reactors without moving elements inside
B01J 41/00 - Anion exchangeUse of material as anion exchangersTreatment of material for improving the anion exchange properties
C07C 215/40 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
C07C 229/36 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
C07D 207/46 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
Method for connecting, in a fluid manner, a system (100) for fluid communication comprising a first (10) and a second (20) fluid valve and comprising the following steps:—providing a first (10) and a second (20) fluid valve, —providing a first pipe (60), —inserting each of the ends (61, 62) of the first pipe (60) into each of the fluid valves (10, 20) in order to form a fluid assembly (100), —providing a compression means (1) comprising two ends (2, 3), —positioning said two ends (2, 3) of said compression means (1) on either side of said fluid assembly (100), —applying a compression force onto said fluid assembly (100) via the compression means (1).
A cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series in a synthesizer, includes: at least one manifold provided with a plurality of valves connectable to and operable by the synthesizer; an anion-exchanger comprising an anionic exchange material; an eluent container comprising an eluent; and a recondition container comprising a reconditioning agent.
C07H 5/02 - Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
C07C 215/40 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
C07C 229/36 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
C07D 207/46 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
Actuators and devices are provided for imparting a rotary movement and comprising in a longitudinal direction first and second hydraulic cylinders, characterised in that the first driver is a linear hydraulic cylinder comprising a first piston, and that the second driver is a linear hydraulic cylinder comprising a second piston, and in that the devices include a member for converting linear motion into rotary motion in order to convert a translation movement of the second piston into a rotary movement.
F16K 31/163 - Operating meansReleasing devices actuated by fluid with a mechanism, other than pulling- or pushing-rod, between fluid motor and closure member the fluid acting on a piston
F16K 31/122 - Operating meansReleasing devices actuated by fluid the fluid acting on a piston
F15B 15/06 - Mechanical layout characterised by the means for converting the movement of the fluid-actuated element into movement of the finally-operated member for mechanically converting rectilinear movement into non-rectilinear movement
F15B 15/14 - Fluid-actuated devices for displacing a member from one position to anotherGearing associated therewith characterised by the construction of the motor unit of the straight-cylinder type
F16H 25/18 - Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms for conveying or interconverting oscillating or reciprocating motions
7.
METHOD FOR CONNECTING AT LEAST TWO FLUID VALVES AND THE SYSTEM FOR FLUID COMMUNICATION IMPLEMENTED
Method for connecting, in a fluid manner, a system (100) for fluid communication comprising a first (10) and a second (20) fluid valve and comprising the following steps: - providing a first (10) and a second (20) fluid valve, - providing a first pipe (60), - inserting each of the ends (61, 62) of the first pipe (60) into each of the fluid valves (10, 20) in order to form a fluid assembly (100), - providing a compression means (1) comprising two ends (2, 3), - positioning said two ends (2, 3) of said compression means (1) on either side of said fluid assembly (100), - applying a compression force onto said fluid assembly (100) via the compression means (1).
A method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series includes carrying out a first synthesis run including the steps of: a) providing water containing fluorine-18; b) trapping the fluorine-18 from the water provided in step a) on an anion exchange material; c) eluting the trapped fluorine-18 from the anion exchange material to a reaction vessel of first radiopharmaceutical synthesis cassette; d) preparing a radiopharmaceutical incorporating the eluted fluorine-18 using the first radiopharmaceutical synthesis cassette; where steps a)-d) are repeated in at least one subsequent run using another radiopharmaceutical synthesis cassette; and where the method includes a reconditioning step of the anion exchange material between two consecutive runs. A device for performing this method and a cassette for use in the device are also disclosed.
C07H 5/02 - Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
C07B 59/00 - Introduction of isotopes of elements into organic compounds
C07D 207/46 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
B01J 19/24 - Stationary reactors without moving elements inside
B01J 41/00 - Anion exchangeUse of material as anion exchangersTreatment of material for improving the anion exchange properties
C07C 215/40 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
C07C 229/36 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
Actuator or device (100) for imparting a rotary movement, and comprising, in a longitudinal direction, a first (1) and a second (2) driver, characterized in that: said first driver (1) is a linear driver comprising a first piston (11); in that said second driver (2) is a linear driver comprising a second piston (12); and in that said device (100) further comprises a member (7) for converting linear motion into rotary motion in order to convert a translation movement of the second piston (12) into a rotary movement.
F16K 31/122 - Operating meansReleasing devices actuated by fluid the fluid acting on a piston
F16K 31/163 - Operating meansReleasing devices actuated by fluid with a mechanism, other than pulling- or pushing-rod, between fluid motor and closure member the fluid acting on a piston
F15B 15/06 - Mechanical layout characterised by the means for converting the movement of the fluid-actuated element into movement of the finally-operated member for mechanically converting rectilinear movement into non-rectilinear movement
F15B 15/14 - Fluid-actuated devices for displacing a member from one position to anotherGearing associated therewith characterised by the construction of the motor unit of the straight-cylinder type
10.
METHOD OF PERFORMING A PLURALITY OF SYNTHESIS PROCESSES OF PREPARING A RADIOPHARMACEUTICAL IN SERIES, A DEVICE AND CASSETTE FOR PERFORMING THIS METHOD
The invention relates to a method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, which method comprises carrying out a first synthesis run comprising the steps of: a) providing water containing 18F; b) trapping the 18F from the water provided in step a) on an anion exchange material (18); c) eluting the trapped 18F from the anion exchange material (18) to a reaction vessel (58) of first radiopharmaceutical synthesis cassette (50'); d) preparing a radiopharmaceutical incorporating the eluted 18F using the first radiopharmaceutical synthesis cassette (50'); wherein steps a)-d) are repeated in at least one subsequent run using another radiopharmaceutical synthesis cassette (50"; 50"'); and wherein the method comprises a reconditioning step of said anion exchange material (18) between two consecutive runs Other aspects of the invention relate to a device for performing this method, and a cassette for use in the device.
The invention relates to a compressed-air device for controlling valves comprising, in a longitudinal direction, a first vane-type rotary cylinder (1) having a front face (2) as well as a back face (4), said front face (2) being provided with a rotatable head (3), and a second vane-type rotary cylinder (10) having a front face (11) and a back face, said first (1) and second (10) cylinders each being supplied with compressed air by means of a compressed air valve connected to two ports (7, 8; 14, 15) on each of said first and second cylinders.
F01C 9/00 - Oscillating-piston machines or engines
F16K 31/16 - Operating meansReleasing devices actuated by fluid with a mechanism, other than pulling- or pushing-rod, between fluid motor and closure member
F15B 11/12 - Servomotor systems without provision for follow-up action with only one servomotor providing distinct intermediate positionsServomotor systems without provision for follow-up action with only one servomotor with step-by-step action
F15B 15/12 - Fluid-actuated devices for displacing a member from one position to anotherGearing associated therewith characterised by the construction of the motor unit of the oscillating-vane or curved-cylinder type
B01J 4/00 - Feed devicesFeed or outlet control devices
The invention relates to a compressed-air device for controlling valves, including, in a longitudinal direction: a first vane-type rotary actuator (1) having a front surface (2) as well as a back surface (4), said front surface (2) being provided with a rotatable head (3); and a second vane-type rotary actuator (10) having a front surface (11) as well as a back surface, each of said first (1) and second (10) actuators being supplied with compressed air via a compressed-air valve connected to two ports (7, 8, 14, 15) on each of said first and second actuators.
F15B 11/12 - Servomotor systems without provision for follow-up action with only one servomotor providing distinct intermediate positionsServomotor systems without provision for follow-up action with only one servomotor with step-by-step action
F15B 15/12 - Fluid-actuated devices for displacing a member from one position to anotherGearing associated therewith characterised by the construction of the motor unit of the oscillating-vane or curved-cylinder type
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