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2023
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Invention
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Composition comprising recombinant clostridium neurotoxin.
The invention provides methods for pr... |
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2022
|
Invention
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Methods for the manufacture of proteolytically processed polypeptides.
The present invention rel... |
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2021
|
Invention
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Cationic neurotoxins. c domain). Also provided are medical uses of the engineered clostridial tox... |
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2020
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Invention
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Methods for the manufacture of proteolytically processed polypeptides. A proteolytically active p... |
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Invention
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Cationic neurotoxins. Method for preventing or treating a condition or disease in a subject compr... |
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2019
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Invention
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Fusion proteins comprising a non-cytotoxic protease, a translocation domain, and a targeting moie... |
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Invention
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Composition comprising recombinant clostridium neurotoxin. The invention provides methods for pro... |
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2018
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Invention
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Carrier for targeting nerve cells. Clostridium botulinum wherein (i) the protein binds specifical... |
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Invention
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Suppression of cancer.
Polypeptides for use in suppressing cancer and cancer disorders and metho... |
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Invention
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Evolution of bont peptidases. etc.etc.) and methods of evolving the same. In some embodiments, pr... |
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Invention
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Methods for the manufacture of proteolytically processed polypeptides. The present invention rela... |
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Invention
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Therapeutic fusion proteins. The present invention relates to the construction of a new class of ... |
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Invention
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Re-targeted toxin conjugates.
The present invention provides a method for designing a re-targete... |
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Invention
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Suppression of itch.
The invention provides a polypeptide, for use in suppressing or treating it... |
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Invention
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Cationic neurotoxins. The present invention provides an engineered clostridial toxin comprising a... |
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2017
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Invention
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Fusion proteins and methods for treating, preventing or ameliorating pain.
A single chain polype... |
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2016
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Invention
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Non-cytotoxic protein conjugates. The present invention is directed to non-cytotoxic protein conj... |
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Invention
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Method for suppressing spasmodic torticollis. The present invention relates to a modified polypep... |
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2015
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Invention
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Clostridium botulinum neurotoxins using lys-c and a hydrophobic surface. Methods for producing di... |
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Invention
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Manufacture of recombinant clostridium botulinum neurotoxins. The invention provides methods for ... |
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Invention
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Cationic neurotoxins. C domain). |
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Invention
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Cationic neurotoxins. The present invention provides engineered clostridial toxins comprising at ... |
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2014
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Invention
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Inhibition of secretion from non-neuronal cells.
The present invention relates to treatment of d... |
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Invention
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Transport protein which is used to introduce chemical compounds into nerve cells. Clostridium bot... |
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Invention
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Suppression of itch. The invention provides a polypeptide, for use in suppressing or treating itc... |
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Invention
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Suppression of cancer. The present invention relates to polypeptides for use in suppressing cance... |
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Invention
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Suppression of neuroendocrine diseases.
The present invention relates to a method for suppressin... |
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Invention
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Suppression of prostate cancer using a targeted clostridial neurotoxin. The present invention rel... |
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Invention
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Therapeutics for suppressing osteoporosis.
The invention provides a polypeptide, for use in supp... |
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Invention
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Therapeutics for suppressing osteoporosis. The invention provides a polypeptide, for use in suppr... |
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2013
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Invention
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Recombinant clostridium botulinum neurotoxins. E. coli host cell, together with methods for produ... |
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Invention
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Recombinant clostridium botulinum neurotoxins. The invention provides a nucleic acid sequence com... |
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Invention
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Assay for assessment of endosomal transport. The invention provides an assay and corresponding ki... |
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Invention
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Fusion proteins and methods for treating, preventing or ameliorating pain. A single chain, polype... |
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Invention
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Fusion proteins. A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease... |
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2012
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Invention
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Method of preparing a fusion protein for the inhibition or reduction of secretion of an extracell... |
