Methods of treating or preventing a C. difficile infection and the associated pathological conditions related to C. difficile infection, are disclosed.
Methods of treating or preventing a bacterial infection in a subject are disclosed herein, wherein the bacterial infection is caused by a bacterium which can be used as a biological weapon. Also disclosed is a pharmaceutical composition comprising the compound of the present invention for treating or preventing a bacterial infection in a subject, wherein the bacterial infection is caused by a bacterium which can be used as a biological weapon.
The present invention provides omadacycline crystalline freebase and methods of synthesis thereof. The present invention also provides pharmaceutical compositions comprising omadacycline crystalline freebase and methods of use thereof for treating bacterial infections. The present invention also provides methods of purifying crude omadacycline freebase that comprise crystallization to produce crystalline omadacycline freebase. The omadacycline crystalline freebase may also be used to prepare salts of omadacycline, e.g., a tosylate salt.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
39 - Services de transport, emballage et entreposage; organisation de voyages
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Printed medication dosage and formulation charts; printed informational cards and brochures in the field of infectious disease; printed informational cards and brochures in the field of pharmaceutical preparations, namely, antibiotics Transportation of goods, namely, antibiotics; delivery and storage of goods; delivery of pharmaceuticals Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; health care services, namely, providing patient access programs to provide eligible patients with streamlined access to drugs in the field of infectious diseases; dispensing of pharmaceuticals; providing an internet website for medical professionals and medical patients featuring medical information that enables users to enter, access, track, monitor and generate health and medical information in the field of infectious diseases
36 - Services financiers, assurances et affaires immobilières
39 - Services de transport, emballage et entreposage; organisation de voyages
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Printed medication dosage and formulation charts; printed informational cards and brochures in the field of infectious disease; printed informational cards and brochures in the field of pharmaceutical preparations, namely, antibiotics Insurance consultancy services in the field of health; insurance services, namely, insurance eligibility review and verification and consultation in the pharmaceutical industry; pharmaceutical benefit management services; insurance administration services, namely, assisting others with applying for insurance benefits Transportation of goods, namely, antibiotics; delivery and storage of goods; delivery of pharmaceuticals Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; health care services, namely, providing patient access programs to provide eligible patients with streamlined access to drugs in the field of infectious diseases; dispensing of pharmaceuticals; providing an internet website for medical professionals and medical patients featuring medical information that enables users to enter, access, track, monitor and generate health and medical information in the field of infectious diseases
05 - Produits pharmaceutiques, vétérinaires et hygièniques
36 - Services financiers, assurances et affaires immobilières
39 - Services de transport, emballage et entreposage; organisation de voyages
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations, namely, antibiotics Insurance consultancy services in the field of health; Insurance services, namely, insurance eligibility review and verification and consultation in the pharmaceutical industry; Pharmaceutical benefit management services Transportation of goods, namely, antibiotics Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; Medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; Health care services, namely, providing patient access programs to provide eligible patients with streamlined access to drugs; Dispensing of pharmaceuticals
7.
CRYSTALLINE FORMS OF OMADACYCLINE, METHODS OF SYNTHESIS THEREOF AND METHODS OF USE THEREOF
The present invention provides omadacycline crystalline freebase and methods of synthesis thereof. The present invention also provides pharmaceutical compositions comprising omadacycline crystalline freebase and methods of use thereof for treating bacterial infections. The present invention also provides methods of purifying crude omadacycline freebase that comprise crystallization to produce crystalline omadaccyline freebase. The omadacycline crystalline freebase may also be used to prepare salts of omadacycline, e.g., a tosylate salt.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
8.
CRYSTALLINE FORMS OF OMADACYCLINE, METHODS OF SYNTHESIS THEREOF AND METHODS OF USE THEREOF
The present invention provides omadacycline crystalline freebase and methods of synthesis thereof. The present invention also provides pharmaceutical compositions comprising omadacycline crystalline freebase and methods of use thereof for treating bacterial infections. The present invention also provides methods of purifying crude omadacycline freebase that comprise crystallization to produce crystalline omadaccyline freebase. The omadacycline crystalline freebase may also be used to prepare salts of omadacycline, e.g., a tosylate salt.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
9.
METHODS OF TREATING COVID-19 USING TETRACYCLINE COMPOUNDS
The present disclosure provides methods of treating or preventing a viral infection, e.g., SARS-CoV-2 infection or an influenza infection; for treating a viral disease, e.g., COVID-19 or influenza; for preventing a secondary bacterial pneumonia in a subject with a viral infection or a viral disease; and for modulating an immune response. The methods comprise administering to a subject in need thereof omadacycline or a pharmaceutically acceptable salt thereof.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
The United States Government as represented by the Department of Veterans Affairs (USA)
Inventeur(s)
Cynamon, Michael Henry
Draper, Michael P.
Steenbergen, Judith N.
Tanaka, S. Ken
Abrégé
The present invention provides methods of treating mycobacterial infections or mycobacterial diseases by administering a tetracycline compound, e.g., omadacycline, or a pharmaceutically acceptable salt thereof.
Methods of treating or preventing a bacterial infection in a subject are disclosed herein, wherein the bacterial infection is caused by a bacterium which can be used as a biological weapon. Also disclosed is a pharmaceutical composition comprising the compound of the present invention for treating or preventing a bacterial infection in a subject, wherein the bacterial infection is caused by a bacterium which can be used as a biological weapon.
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing information in the fields of health, medicine, and
pharmaceuticals for the treatment of infectious disease;
medical information services, namely, providing information
to physicians, healthcare professionals, and patients on the
topics of health issues, pharmaceutical products, and health
awareness in the field of infectious diseases; health care
services, namely, providing patient access programs to
provide eligible patients with streamlined access to drugs;
dispensing of pharmaceuticals; providing cumulative medical
information that enables users to enter, access, track, and
monitor and generate health and medical information via an
interactive internet website for medical professionals and
medical patients.
13.
METHODS OF TREATING MYCOBACTERIAL INFECTIONS USING TETRACYCLINE COMPOUNDS
UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (USA)
PARATEK PHARMACEUTICALS, INC. (USA)
Inventeur(s)
Cynamon, Michael Henry
Draper, Michael P.
Steenbergen, Judith N.
Tanaka, S. Ken
Abrégé
The present invention provides methods of treating mycobacterial infections or mycobacterial diseases by administering a tetracycline compound, e.g., omadacycline, or a pharmaceutically acceptable salt thereof.
UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (USA)
Inventeur(s)
Cynamon, Michael, Henry
Draper, Michael, P.
Steenbergen, Judith, N.
Tanaka, S., Ken
Abrégé
The present invention provides methods of treating mycobacterial infections or mycobacterial diseases by administering a tetracycline compound, e.g., omadacycline, or a pharmaceutically acceptable salt thereof.
The invention disclosed herein provides a method for treating Community-Acquired Bacterial Pneumonia (CABP) using 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, in either oral or IV doses or a combination of both.
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; health care services, namely, providing patient access programs to provide eligible patients with streamlined access to drugs; dispensing of pharmaceuticals; providing cumulative medical information that enables users to enter, access, track, and monitor and generate health and medical information via an interactive internet website for medical professionals and medical patients.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Hosting an interactive web site featuring technology that
enables users to access, track, monitor, and generate
reports relating to antibiotics and bacterial susceptibility
and resistance patterns; design of an Internet-based
database of cumulative medical and scientific research data
on bacterial susceptibility surveillance to monitor changes
in resistance patterns and provide doctors and the
healthcare community information on the activity of an
antibacterial drug to an organism over time. Medical information services, namely, reporting of
drug-resistance patterns over time; providing cumulative
data on bacterial susceptibility surveillance to monitor
changes in resistance patterns and provide doctors and the
healthcare community information on the activity of an
antibacterial drug to an organism over time for medical
treatment purposes via an on-line computer database.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
C07C 231/12 - Préparation d'amides d'acides carboxyliques par des réactions n'impliquant pas la formation de groupes carboxamide
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing an interactive website featuring technology that enables users to access, track, monitor, and generate reports relating to antibiotics and bacterial susceptibility and resistance patterns. Medical information services, namely, reporting of drug-resistance patterns over time; providing an internet-based database of cumulative data on bacterial susceptibility surveillance to monitor changes in resistance patterns and provide doctors and the healthcare community information on the activity of an antibacterial drug to an organism over time.
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical information services, namely, reporting of
drug-resistance patterns overtime; providing cumulative data
on bacterial susceptibility surveillance to monitor changes
in resistance patterns and provide doctors and the
healthcare community information on the activity of an
antibacterial drug to an organism overtime for medical
treatment purposes via an on-line computer database.
36 - Services financiers, assurances et affaires immobilières
39 - Services de transport, emballage et entreposage; organisation de voyages
Produits et services
Insurance consultancy services in the field of health; Insurance services, namely, insurance eligibility review and verification and consultation in the pharmaceutical industry; Pharmaceutical benefit management services; Insurance administration services, namely, assisting others with applying for insurance benefits Transportation of goods, namely, antibiotics; delivery and storage of goods; delivery of pharmaceuticals
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; health care services, namely, providing patient access programs to provide eligible patients with streamlined access to drugs; dispensing of pharmaceuticals; providing an internet website for medical professionals and medical patients that provides cumulative medical information for use by medical professionals and medical patients
05 - Produits pharmaceutiques, vétérinaires et hygièniques
16 - Papier, carton et produits en ces matières
36 - Services financiers, assurances et affaires immobilières
39 - Services de transport, emballage et entreposage; organisation de voyages
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations, namely, antibiotics. Printed medication dosage and formulation charts; printed
informational cards and brochures in the field of infectious
disease; printed informational cards and brochures in the
field of pharmaceutical preparations, namely, antibiotics. Insurance consultancy services in the field of health;
insurance services, namely, insurance eligibility review and
verification and consultation in the pharmaceutical
industry; pharmaceutical benefit management services;
insurance administration services, namely, assisting others
with applying for insurance benefits. Transportation of goods, namely, antibiotics; delivery and
storage of goods; delivery of pharmaceuticals. Providing information in the fields of health, medicine, and
pharmaceuticals for the treatment of infectious disease;
medical information services, namely, providing information
to physicians, healthcare professionals, and patients on the
topics of health issues, pharmaceutical products, and health
awareness in the field of infectious diseases; health care
services, namely, providing patient access programs to
provide eligible patients with streamlined access to drugs;
dispensing of pharmaceuticals; providing an internet website
for medical professionals and medical patients featuring
medical information that enables users to enter, access,
track, monitor and generate health and medical information.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
16 - Papier, carton et produits en ces matières
36 - Services financiers, assurances et affaires immobilières
39 - Services de transport, emballage et entreposage; organisation de voyages
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Pharmaceutical preparations, namely, antibiotics
(2) Printed medication dosage and formulation charts; printed informational cards and brochures in the field of infectious disease; printed informational cards and brochures in the field of pharmaceutical preparations, namely, antibiotics (1) Insurance consultancy services in the field of health; Insurance services, namely, insurance eligibility review and verification and consultation in the pharmaceutical industry; Pharmaceutical benefit management services; Insurance administration services, namely, assisting others with applying for insurance benefits
(2) Transportation of goods via automobiles and airplanes, namely, antibiotics; delivery and storage of pharmaceuticals; delivery of pharmaceuticals.
(3) Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; Medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; Health care services, namely, providing patient access programs to provide eligible patients with streamlined access to drugs; Dispensing of pharmaceuticals; Providing medical information that enables users to enter, access, track, monitor and generate health and medical information in the field of infectious diseases via a website for medical professionals and medical students.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
16 - Papier, carton et produits en ces matières
36 - Services financiers, assurances et affaires immobilières
39 - Services de transport, emballage et entreposage; organisation de voyages
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations, namely, antibiotics. Printed medication dosage and formulation charts; printed informational cards and brochures in the field of infectious disease; printed informational cards and brochures in the field of pharmaceutical preparations, namely, antibiotics. Insurance consultancy services in the field of health; Insurance services, namely, insurance eligibility review and verification and consultation in the pharmaceutical industry; financial management of pharmaceutical benefits; Insurance administration services, namely, assisting others with applying for insurance benefits. Transportation of goods, namely, antibiotics; delivery and storage of goods; delivery of pharmaceuticals. Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; Medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; Health care services, namely, providing patient access programs to provide eligible patients with streamlined access to drugs; Dispensing of pharmaceuticals; Providing an internet website for medical professionals and medical patients featuring medical information that enables users to enter, access, track, monitor and generate health and medical information.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
36 - Services financiers, assurances et affaires immobilières
39 - Services de transport, emballage et entreposage; organisation de voyages
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations, namely, antibiotics. Insurance consultancy services in the field of health; Insurance services, namely, insurance eligibility review and verification and consultation in the pharmaceutical industry; financial management of pharmaceutical benefits. Transportation of goods, namely, antibiotics. Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; Medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; Health care services, namely, providing patient access programs to provide eligible patients with streamlined access to drugs; Dispensing of pharmaceuticals.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
35 - Publicité; Affaires commerciales
36 - Services financiers, assurances et affaires immobilières
39 - Services de transport, emballage et entreposage; organisation de voyages
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Pharmaceutical preparations, namely, antibiotics (1) Administration of pharmaceutical benefit plans for individuals
(2) Insurance consultancy services in the field of health; Insurance services, namely, insurance eligibility review and verification and consultation in the pharmaceutical industry.
(3) Transportation of goods, namely, antibiotics
(4) Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; Medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; Health care services, namely, providing patient access programs to provide eligible patients with streamlined access to drugs; Dispensing of pharmaceuticals
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing an interactive web site featuring technology that enables users to access, track, monitor, and generate reports relating to antibiotics and bacterial susceptibility and resistance patterns; providing an internet-based database of cumulative medical and scientific research data on bacterial susceptibility surveillance to monitor changes in resistance patterns and provide doctors and the healthcare community information on the activity of an antibacterial drug to an organism over time Medical information services, namely, reporting of drug-resistance patterns over time; providing an internet-based database of cumulative data on bacterial susceptibility surveillance to monitor changes in resistance patterns and provide doctors and the healthcare community information on the activity of an antibacterial drug to an organism over time for medical treatment purposes
36 - Services financiers, assurances et affaires immobilières
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Printed medication dosage and formulation charts; printed informational cards and brochures in the field of infectious disease; printed informational cards and brochures in the field of pharmaceutical preparations, namely, antibiotics Insurance consultancy services in the field of health; Insurance services, namely, insurance eligibility review and verification and consultation in the pharmaceutical industry; Pharmaceutical benefit management services; Insurance administration services, namely, assisting others with applying for insurance benefits Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; Medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; Health care services, namely, providing patient access programs to provide eligible patients with streamlined access to drugs; Dispensing of pharmaceuticals; Providing an internet website for medical professionals and medical patients featuring medical information that enables users to enter, access, track, monitor and generate health and medical information
36 - Services financiers, assurances et affaires immobilières
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Printed medication dosage and formulation charts; printed informational cards and brochures in the field of infectious disease; printed informational cards and brochures in the field of pharmaceutical preparations, namely, antibiotics Insurance consultancy services in the field of health; Insurance services, namely, insurance eligibility review and verification and consultation in the pharmaceutical industry; Pharmaceutical benefit management services; Insurance administration services, namely, assisting others with applying for insurance benefits Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; Medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; Health care services, namely, providing patient access programs to provide eligible patients with streamlined access to drugs; Dispensing of pharmaceuticals; Providing an internet website for medical professionals and medical patients featuring medical information that enables users to enter, access, track, monitor and generate health and medical information
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations, namely, antibiotics. Providing information in the fields of health, medicine, and
pharmaceuticals for the treatment of infectious disease;
medical information services, namely, providing information
to physicians, healthcare professionals, and patients on the
topics of health issues, pharmaceutical products, and health
awareness in the field of infectious diseases; health care
services, namely, providing patient assistance programs to
provide eligible patients with access to drugs.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Pharmaceutical Preparations, namely, antibiotics (1) Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; Medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; Health care services, namely, providing patient assistance programs to provide eligible patients with access to drugs
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical Preparations, namely, antibiotics. Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; Medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; Health care services, namely, providing patient assistance programs to provide eligible patients with access to drugs.
37.
9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (CABP)
The invention disclosed herein provides a method for treating Community-Acquired Bacterial Pneumonia (CABP) using 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, in either oral or IV doses or a combination of both.
The invention disclosed herein provides a method for treating Community-Acquired Bacterial Pneumonia (CABP) using 9-[(2,2-dimethyl-propyl amino)-methyl] -minocycline or a salt thereof, in either oral or IV doses or a combination of both.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
The invention disclosed herein provides a method for treating Community-Acquired Bacterial Pneumonia (CABP) using 9-[(2,2-dimethyl-propyl amino)-methyl] -minocycline or a salt thereof, in either oral or IV doses or a combination of both.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein the 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline is administered orally at a dose of about 450 mg per day for two consecutive days, then at a dose of about 300 mg per day for 5 or more days.
Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein the 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline is administered orally at a dose of about 450 mg per day for two consecutive days, then at a dose of about 300 mg per day for 5 or more days.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
48.
9-AMINOMETHYL MINOCYCLINE COMPOUNDS AND USES THEREOF
Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein the 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline is administered orally at a dose of about 450 mg per day for two consecutive days, then at a dose of about 300 mg per day for 5 or more days.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations, namely, antibiotics Providing information in the fields of health, medicine, and pharmaceuticals for the treatment of infectious disease; medical information services, namely, providing information to physicians, healthcare professionals, and patients on the topics of health issues, pharmaceutical products, and health awareness in the field of infectious diseases; Health care services, namely, providing patient assistance programs to provide eligible patients with access to drugs
51.
9-AMINOMETHYL MINOCYCLINE COMPOUNDS AND METHODS OF USE THEREOF IN URINARY TRACT INFECTION (UTI) TREATMENT
The disclosed invention provides a method for treating urinary tract infection (UTI) using 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, in either oral or IV doses or a combination of both.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
52.
METHODS OF TREATING A BACTERIAL INFECTION IN A SUBJECT AT RISK OF DEVELOPING C. DIFFICILE INFECTION
Methods of treating or preventing a C. difficile infection and the associated pathological conditions related to C. difficile infection, are disclosed.
Methods of treating or preventing a C. difficile infection and the associated pathological conditions related to C. difficile infection, are disclosed.
Methods of treating or preventing a bacterial infection in a subject are disclosed herein, wherein the bacterial infection is caused by a bacterium which can be used as a biological weapon. Also disclosed is a pharmaceutical composition comprising the compound as represented by the structural folinula:for treating or preventing a bacterial infection in a subject, wherein the bacterial infection is caused by a bacterium which can be used as a biological weapon.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
55.
ORAL AND INJECTABLE FORMULATIONS OF TETRACYCLINE COMPOUNDS
Injectable and oral formulations of a tetracycline compound are described. In one embodiment, the invention pertains to an oral formulation of a 9-aminomethyl tetracycline compound, or a salt thereof, in tablet form or capsule. The formulations may be used, for example, to treat infections.
Methods of treating or preventing a bacterial infection in a subject are disclosed herein, wherein the bacterial infection is caused by a bacterium which can be used as a biological weapon. Also disclosed is a pharmaceutical composition comprising the compound of the present invention for treating or preventing a bacterial infection in a subject, wherein the bacterial infection is caused by a bacterium which can be used as a biological weapon.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations, namely antibiotics. Conducting early evaluations in the field of new
pharmaceuticals; development of pharmaceutical preparations
and medicines; pharmaceutical products development;
pharmaceutical research and development; research and
development in the pharmaceutical and biotechnology fields;
research in the field of pharmaceuticals, drugs and
antibiotics.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations. Conducting early evaluations in the field of new
pharmaceuticals; development of pharmaceutical preparations
and medicines; pharmaceutical products development;
pharmaceutical research and development; research and
development in the pharmaceutical and biotechnology fields;
research in the field of pharmaceuticals, drugs and
antibiotics.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Pharmaceutical preparations, namely antibiotics; pharmaceutical preparations for the treatment of cancer; pharmaceutical preparations for the prevention and treatment of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases; pharmaceutical preparations for the prevention and treatment of immunologic diseases, namely, autoimmune diseases, immunologic deficiency syndromes; pharmaceutical preparations for the prevention and treatment of cardiovascular diseases; pharmaceutical preparations for the prevention and treatment of diabetes; pharmaceutical preparations for the prevention and treatment of metabolic disorders, namely, diabetes, obesity, hyperlipidemia, insulin resistance, metabolic syndrome; anti-inflammatories; pharmaceutical preparations for the prevention and treatment of disorders of the respiratory system; pharmaceutical preparations for the prevention and treatment of disorders of the musculo-skeletal system, namely, connective tissue disease, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries; pharmaceutical preparations for the prevention and treatment of genitourinary diseases, namely, urological diseases, infertility, sexually transmitted diseases, inflammatory pelvic diseases; pharmaceutical preparations for use in dermatology, namely, dermatitis, skin pigmentation diseases, sexually transmitted diseases; pharmaceutical preparations for use in oncology; pharmaceutical preparations for use in hematology, namely for the treatment of blood disorders; pharmaceutical preparations for use in tissue and organ transplantation; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for use in gastroenterology; pharmaceutical preparations for prevention and treatment of ocular disorders and diseases. (1) Conducting early evaluations in the field of new pharmaceuticals, namely conducting clinical and pre-clinical trials; development of pharmaceutical preparations and medicines; pharmaceutical products development; pharmaceutical research and development; research and development in the pharmaceutical and biotechnology fields; research in the field of pharmaceuticals, drugs and antibiotics.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Pharmaceutical preparations, namely, antibiotics. (1) Conducting early evaluations in the field of new pharmaceuticals; Development of pharmaceutical preparations and medicines; Pharmaceutical products development; Pharmaceutical research and development; Research and development in the pharmaceutical and biotechnology fields; Research in the field of pharmaceuticals, drugs and antibiotics.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Pharmaceutical preparations, namely, antibiotics (1) Conducting early evaluations in the field of new pharmaceuticals; development of pharmaceutical preparations and medicines; pharmaceutical products development; pharmaceutical research and development; research and development in the pharmaceutical and biotechnology fields; research in the field of pharmaceuticals, drugs and antibiotics.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations, namely, antibiotics. Conducting early evaluations in the field of new pharmaceuticals; Development of pharmaceutical preparations and medicines; Pharmaceutical products development; Pharmaceutical research and development; Research and development in the pharmaceutical and biotechnology fields; Research in the field of pharmaceuticals, drugs and antibiotics.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Conducting early evaluations in the field of new pharmaceuticals; Development of pharmaceutical preparations and medicines; Pharmaceutical products development; Pharmaceutical research and development; Research and development in the pharmaceutical and biotechnology fields; Research in the field of pharmaceuticals, drugs and antibiotics
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Conducting early evaluations in the field of new pharmaceuticals; Development of pharmaceutical preparations and medicines; Pharmaceutical products development; Pharmaceutical research and development; Research and development in the pharmaceutical and biotechnology fields; Research in the field of pharmaceuticals, drugs and antibiotics
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical Preparations, namely, antibiotics Conducting early evaluations in the field of new pharmaceuticals; Development of pharmaceutical preparations and medicines; Pharmaceutical products development; Pharmaceutical research and development; Research and development in the pharmaceutical and biotechnology fields; Research in the field of pharmaceuticals, drugs and antibiotics
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations, namely, antibiotics Conducting early evaluations in the field of new pharmaceuticals; Development of pharmaceutical preparations and medicines; Pharmaceutical products development; Pharmaceutical research and development; Research and development in the pharmaceutical and biotechnology fields; Research in the field of pharmaceuticals, drugs and antibiotics
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations, namely, antibiotics Conducting early evaluations in the field of new pharmaceuticals; Development of pharmaceutical preparations and medicines; Pharmaceutical products development; Pharmaceutical research and development; Research and development in the pharmaceutical and biotechnology fields; Research in the field of pharmaceuticals, drugs and antibiotics
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Conducting early evaluations in the field of new pharmaceuticals; Development of pharmaceutical preparations and medicines; Pharmaceutical products development; Pharmaceutical research and development; Research and development in the pharmaceutical and biotechnology fields; Research in the field of pharmaceuticals, drugs and antibiotics
80.
Methods for synthesizing and purifying aminoalkyl tetracycline compounds
Tetracycline compounds for treating neurodegenerative disorders are disclosed herein. Also disclosed is a pharmaceutical composition comprising the tetracycline compounds, and a method for treating, preventing, or ameliorating neurodegenerative disorders or inflammation in a subject by administering the tetracycline compounds or a pharmaceutical composition thereof, either alone or in combination with a second therapeutic agent.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
82.
Substituted tetracycline compounds for treatment of inflammatory skin disorders
C07C 237/48 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins l'un des groupes carboxamide lié à un atome de carbone d'un cycle aromatique à six chaînons faisant partie d'un système cyclique condensé du même squelette carboné
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
7-Disubstituted-phenyl tetracycline compounds are disclosed herein. Also disclosed is a method for treatment or prevention of spinal muscular atrophy using the 7-disubstituted-phenyl tetracycline compounds. This invention also relates to a method for treating or preventing a subject having spinal muscular atrophy. The method includes administering to the subject an effective amount of a tetracycline compound of formula (1 ), such that the spinal muscular atrophy is treated or prevented. Advantageously, the tetracycline compounds used in this method of the invention have one or more of the following characteristics: 1 ) potency in modulating mRNA splicing, 2) potency in modulating SMN protein levels, 3) central nervous system (CNS) and/pr brain penetration, 4) decreased phototoxic properties and 5) decreased antibacterial properties.
METHODS OF USING (4S,4AS,5AR,12AS)-4- DIMETHYLAMINO-3,10,12,12A-TETRAHYDROXY-7-[(METHOXY(METHYL)AMINO)-METHYL]-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-NAPHTHACENE-2-CARBOXYLIC ACID AMIDE
A method of treating a bacterial infection, e.g., a bacterial infection with methicillin resistant Staphylococcus aureus, Helicobacter pylori, Chlamydia trachomatis, or Chlamydia pneumonia, comprising administering to a subject (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7- [(methoxy(methyl)amino)-methyl] -1,11-dioxo-1,4,4a,5,5a,6, 11, 12a-octahydronaphthacene-2-carboxylic acid amide or a pharmaceutically acceptable salt thereof is disclosed. More specifically, a method of treating a bacterial infection comprising administering to a subject crystalline mono hydrochloride salt, crystalline mono mesylate salt or crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7- [(methoxy(methyl)amino)-methyl]-l,l l-dioxo-l,4,4a,5,5a,6,l l,12a-octahydro- naphthacene-2-carboxylic acid amide is disclosed.
CRYSTALLINE SALTS OF (4S,4AS,5AR,12AS)-4-DIMETHYLAMINO-3,10,12,12A-TETRAHYDROXY-7-[(METHOXY(METHYL)AMINO)-METHYL]-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-NAPHTHACENE-2-CARBOXYLICACID AMIDE AND METHODS OF USING THE SAME
ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED (USA)
Inventeur(s)
Coulter, Catherine
Johnston, Sean M.
Seyedi, Farzaneh
Abrégé
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino- 3,10, 12, 12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]- 1, 11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7- [(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene- 2-carboxylic acid amide are also disclosed having improved stability. A pharmaceutical composition containing the crystalline salts and methods of treating inflammatory skin disorders and bacterial infections comprising administering the crystalline salts are also disclosed.
C07C 239/20 - Composés hydroxylaminés ou leurs éthers ou esters ayant des atomes d'oxygène de groupes hydroxylamino éthérifiés
86.
CRYSTALLINE SALTS OF (4S,4AS,5AR,12AS)-4-DIMETHYLAMINO-3,10,12,12A-TETRAHYDROXY-7-[(METHOXY(METHYL)AMINO)-METHYL]-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-NAPHTHACENE-2-CARBOXYLIC ACID AMIDE AND METHODS OF USING THE SAME
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino- 3,10, 12, 12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]- 1, 11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7- [(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene- 2-carboxylic acid amide are also disclosed having improved stability. A pharmaceutical composition containing the crystalline salts and methods of treating inflammatory skin disorders and bacterial infections comprising administering the crystalline salts are also disclosed.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
87.
TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF
Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections, are also provided.
C07D 403/04 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
The present invention pertains, at least in part, to substituted tetracycline compounds. The present invention also pertains to methods for treating rheumatoid arthritis in a subject, comprising administering to the subject a tetracycline compound of the invention.
A01N 37/18 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant le groupe —CO—N, p. ex. amides ou imides d'acide carboxyliqueLeurs thio-analogues
Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
C07C 231/12 - Préparation d'amides d'acides carboxyliques par des réactions n'impliquant pas la formation de groupes carboxamide
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
C07C 303/32 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides de sels d'acides sulfoniques
C07C 309/30 - Acides sulfoniques ayant des groupes sulfo liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné de cycles aromatiques à six chaînons non condensés de cycles aromatiques à six chaînons substitués par des groupes alkyle
Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
A01N 37/18 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant le groupe —CO—N, p. ex. amides ou imides d'acide carboxyliqueLeurs thio-analogues
The present invention pertains, at least in part, to methods of treating a microorganism-associated infection in a subject comprising administering to said subject an effective amount of a tetracycline compound.
A01N 37/18 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant le groupe —CO—N, p. ex. amides ou imides d'acide carboxyliqueLeurs thio-analogues
92.
ORAL AND INJECTABLE FORMULATIONS OF TETRACYCLINE COMPOUNDS
Injectable and oral formulations of a tetracycline compound are described. In one embodiment, the invention per-tains to an oral formulation of a 9-aminomethyl tetracycline compound, or a salt thereof, in tablet form or capsule. The formula-tions may be used, for example, to treat infections.
An injectable formulation of a tetracycline compound is described. In one embodiment, the invention pertains to an injectable formulation comprising about 90-110 mg of 9-[(2,2-dimethyl- propyl amino)-methyl]-minocycline, a lyoprotectant, a pH adjustment compound sufficient to adjust pH of the formulation to between about 4.0 and about 4.5 and an aqueous carrier.
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
Injectable and oral formulations of a tetracycline compound are described. In one embodiment, the invention pertains to an oral formulation of a 9-aminomethyl tetracycline compound, or a salt thereof, in tablet form or capsule. The formulations may be used, for example, to treat infections.
Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9- [(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B- streptococci, Viridans Streptococci, Enterococcus, or combinations thereof.
Methods for synthesizing a carboxaldehyde substituted tetracycline compound comprising reacting a tetracycline reactive intermediate under appropriate conditions with carbon monoxide, a palladium catalyst, a phosphine ligand, a silane and a base, such that said carboxaldehyde substituted tetracycline compound is synthesized. The palladium catalyst is chosen from PdCl2 (tBu2PhP)2 dichlorobis (di-tert-butylphenylphosphine palladium (II)] or PdCl2 (DPEPhos) [bis (diphenylphosphinophenyl) ether palladium (II) chloride]. The tetracycline reactive intermediate contains moieties selected from halogens and triflates. Methods of synthesizing a substituted tetracycline compound comprising reacting the carboxaldehyde substituted tetracycline compound under palladium catalyzed coupling conditions, hydrogenolysis conditions or reductive amination conditions.
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
97.
TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF
Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections.
A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
A61P 13/02 - Médicaments pour le traitement des troubles du système urinaire de l'urine ou des voies urinaires, p. ex. acidificateurs d'urine
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
C07C 237/26 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné d'un cycle faisant partie d'un système cyclique condensé formé par au moins quatre cycles, p. ex. tétracycline
C07C 231/12 - Préparation d'amides d'acides carboxyliques par des réactions n'impliquant pas la formation de groupes carboxamide
Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
A61K 31/422 - Oxazoles non condensés et contenant d'autres hétérocycles
A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p. ex. phosphate de pyridoxal
C07D 235/22 - BenzimidazolesBenzimidazoles hydrogénés avec des hétéro-atomes liés directement aux atomes d'azote du cycle
C07D 403/04 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
