An analysis system and/or method including a mass spectrometer. The mass spectrometer may be configured to conduct a measurement on a sample using at least one laser-shot and generate a distribution of measured data for the at least one laser-shot on the sample. The measurement on the sample is a manufacturing technique. The manufacturing technique relates to component costs.
A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness. A different set of processing modules may be selected for a particular disease type (e.g. such as cancer) to be diagnosed. The system may be used to identify biomaterials such as bacteria, virus, and fungi from body fluids like blood, urine, and saliva and other cells.
The present invention relates to a noise-reducing intake device for increasing the output of an internal combustion engine and, more specifically, to a noise-reducing intake device, for increasing the output of an internal combustion engine, which is provided on an intake unit of an internal combustion engine of a vehicle or the like, is provided with an air vortex generator and enhances the airflow by means of turning the air being taken in or exhausted into a rotating vortex, and thus enhances the combustion efficiency by means of enhanced output in accordance with the intake/exhaust efficiency and thus increases fuel efficiency, reduces noise due to flow separation, reduces smoke, and extends the life of an engine. The noise-reducing intake device for increasing the output of an internal combustion engine has an inner pipe (12), having a hollow (13), in the inside of a cylindrical pipe (11) provided between the outside of the internal combustion engine and the engine, has, at fixed intervals, 3 to 6 vortex blades (15) formed inclinedly so as to have a spiral form in one direction in a space (14) between the cylindrical pipe (11) and the inner pipe (12), and thus enables the air to be supplied in one direction and form a vortex. The vortex blades (15) have corrugated patterns continuously formed on the entry part with which the air taken in initially comes into contact. The corrugated patterns have curved parts (16, 16a, 16b), formed concavely and convexly in the form of either a semicircular curve or an elliptical curve, and thus reduce flow separation and facilitate the airflow.
F02B 31/04 - Modification des systèmes d'admission pour imprimer un mouvement de rotation à la charge dans le cylindre par des moyens situés dans le conduit d'admission, p. ex. des chicanes
F01N 1/12 - Silencieux caractérisés par leur principe de fonctionnement réduisant l'énergie des gaz évacués par étranglement ou tourbillon utilisant des canalisations en spirale ou en hélice
5.
NOISE REDUCTION-TYPE EXHAUST DEVICE FOR ENHANCING OUTPUT OF INTERNAL COMBUSTION ENGINE
The present invention relates to a noise reduction-type exhaust device for enhancing the output of an internal combustion engine and, more particularly, to a noise reduction-type exhaust device for enhancing the output of an internal combustion engine in which an air vortex generator is installed in an exhaust part of an internal combustion engine such as a vehicle to make the intake and exhaust air into a rotating vortex so as to improve the flow of air, thereby improving the combustion efficiency by improving the output according to the intake and exhaust efficiency, resulting in an improvement in fuel efficiency, a reduction of noise caused by a flow separation phenomenon, and, when a tension-type vortex leaf spring is twisted and installed in a hollow of an inner pipe, a reduction of noise and smoke according to a screw type, thereby extending the lifespan of the engine. The present invention provides a noise reduction-type exhaust device for enhancing the output of an internal combustion engine, in which an inner pipe (12) having a hollow (13) is formed in the inner diameter of an exhaust pipe (11) provided between the internal combustion engine and the outside, connection holes are formed at the inner pipe (12) at regular intervals to install vortex blades (15) provided between the inner pipe and the exhaust pipe (11) and having outwardly curving parts (16, 16a, 16b) formed by arranging one of a serrated, triangular, or rectangular form in a concavo-convex shape, and air is supplied in one direction to form a vortex, wherein a vortex blade (15) has a large protrusion part (19) and small protrusion parts (19a, 19b) coupled to a connection hole (12a) so as to be coupled to the connection hole, wherein a small protrusion part (19a) is formed below a vertical surface (17) of a vortex blade (15), and a small protrusion part (19b) is formed in the center between the small protrusion part (19a) and the large protrusion part (19), and then the small protrusion parts (19a, 19b) are formed to have the length and the height of the connection hole (12a) of the inner pipe (12), and the large protrusion part (19) formed at the lower side of an inclined surface (18) has the same length as the connection hole (12a) of the inner pipe (12) and protrudes 2 to 7 times longer in height so as to form a vortex in the hollow (13), and wherein the vertical surface (17) protrudes vertically from the inside having a gap (h) at the tip of the inner pipe (12), and on the opposite side, the inclined surface (18) is formed in the direction from the inner diameter to the outer diameter so that the tip of the outer diameter protrudes more than the tip of the inner pipe (12).
F01N 1/12 - Silencieux caractérisés par leur principe de fonctionnement réduisant l'énergie des gaz évacués par étranglement ou tourbillon utilisant des canalisations en spirale ou en hélice
F01N 13/08 - Autres aménagements ou adaptations des tubulures d'échappement
6.
Integrated disease diagnostic system using matrix-assisted laser desorption/ionization time-of-flight mass spectrometer
A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness. A different set of processing modules may be selected for a particular disease type (e.g. such as cancer) to be diagnosed. The system may be used to identify biomaterials such as bacteria, virus, and fungi from body fluids like blood, urine, and saliva and other cells.
A mass spectrometer using near infrared (NIR) fluorescence can comprise: a plate formed such that a sample, which includes a matrix for ionization and a fluorescent material having an excitation wavelength of an NIR wavelength band, is loaded thereon; a fluorescence detection unit formed so as to acquire a fluorescence image by using the fluorescent material from the sample on the plate; a light emission unit formed so as to emit a laser beam for ionization at the sample on the plate; and an ion detection unit formed so as to detect, by using the laser beam, ions generated from the sample. By using the NIR fluorescence, fluorescence interference due to a matrix used for MALDI imaging can be excluded even after coating the matrix, and since fluorescence interference due to auto-fluorescence inside tissue is low, fluorescence can be measured even for a thick sample.
G01N 21/359 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge proche
G01N 27/62 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'ionisation des gaz, p. ex. des aérosolsRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant les décharges électriques, p. ex. l'émission cathodique
A mass spectrometer using near infrared (NIR) fluorescence can comprise: a plate formed such that a sample, which includes a matrix for ionization and a fluorescent material having an excitation wavelength of an NIR wavelength band, is loaded thereon; a fluorescence detection unit formed so as to acquire a fluorescence image by using the fluorescent material from the sample on the plate; a light emission unit formed so as to emit a laser beam for ionization at the sample on the plate; and an ion detection unit formed so as to detect, by using the laser beam, ions generated from the sample. By using the NIR fluorescence, fluorescence interference due to a matrix used for MALDI imaging can be excluded even after coating the matrix, and since fluorescence interference due to auto-fluorescence inside tissue is low, fluorescence can be measured even for a thick sample, and thus accurate analysis can be performed by performing MALDI imaging on a more important part, of a sample, which is determined on the basis of a fluorescence image.
G01N 27/62 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'ionisation des gaz, p. ex. des aérosolsRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant les décharges électriques, p. ex. l'émission cathodique
H01J 49/26 - Spectromètres de masse ou tubes séparateurs de masse
G01N 21/359 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge proche
9.
APPARATUS, METHOD AND COMPUTER PROGRAM FOR SPECTRUM ANALYSIS
An apparatus for spectrum analysis may comprise: an input unit configured so as to receive a plurality of spectra, each spectrum containing one or more peaks having variance and strength corresponding thereto; a common peak detection unit configured so as to detect common peaks present within a previously configured range in the plurality of spectra; and a representative spectrum generation unit configured so as to calculate a representative peak from the common peaks, and to generate the representative spectrum comprising the variance and strength information of the representative peak. According to the apparatus for spectrum analysis, a representative spectrum for a specimen can be produced with errors and noise caused by experimental environment and conditions eliminated from measured values, and if the representative spectra for multiple types of substances are stored in a database, then an unknown substance can be identified within a very short period of time by means of database matching.
G01N 27/62 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'ionisation des gaz, p. ex. des aérosolsRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant les décharges électriques, p. ex. l'émission cathodique
G01N 33/483 - Analyse physique de matériau biologique
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
10.
METHOD FOR ANALYSING N-GLYCANS IN COMPLEX BIOLOGICAL FLUIDS
A method for analysing N-glycans in complex biological fluids may comprise the steps of: adding protein to a sample including N-glycans, the protein including first marker glycans that have a different mass from the N-glycans; denaturing the protein in the sample after the step of adding the protein; separating glycans in the sample from the protein using an enzyme after the protein has denaturised; eluting glycans from the sample in which the protein is separated; obtaining a mass spectrum of the eluted glycans; and determining the efficiency or reaction of the enzyme based on the amount of first marker glycans in the mass spectrum. Using the method, pure N-glycans can be separated and refined from various complex biological fluids including serum, and data reliability can be improved by maximising efficiency and reproducibility in a short time using a well plate.
G01N 27/62 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'ionisation des gaz, p. ex. des aérosolsRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant les décharges électriques, p. ex. l'émission cathodique
G01N 1/28 - Préparation d'échantillons pour l'analyse
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Physical and chemical laboratory apparatus and instruments for mass spectrometry; Analysis apparatus for laboratory use in the nature of microorganism and biological fluid analysis apparatus; Incubators for bacteria culture; Incubators for bacteria culture for laboratory use; laboratory apparatus for analyzing DNA using mass spectrometry Medical apparatus and instruments other than for dental purposes, namely, in-vitro diagnostics medical device; Diagnostic apparatus for measuring cancer diagnostics; Cancer diagnosis apparatus; DNA extraction and purification apparatus for medical purposes; Genetic testing apparatus, namely, apparatus for medical diagnostic testing in the field of clinical pathology
Medical apparatus and instruments other than for dental purposes, namely, in-vitro diagnostics medical device; diagnostic apparatus for measuring cancer diagnostics; Cancer diagnosis apparatus; DNA extraction and purification apparatus for medical purposes; genetic testing apparatus, namely, apparatus for medical diagnostic testing in the field of clinical pathology
13.
Quantitative analysis method using mass spectrometry wherein laser pulse energy is adjusted
A quantitative analysis method using MALDI mass spectrometry wherein laser pulse energy is adjusted is disclosed. More particularly, a method for measuring the equilibrium constant of a proton exchange reaction between a matrix and a sample at a constant temperature, by dividing an ion signal ratio by a value (concentration ratio) obtained by dividing the concentration of the sample by the concentration of the matrix, may include (i) obtaining MALDI mass spectra having constant TICs by adjusting the intensity of energy applied to a specimen having a predetermined amount of a matrix and a predetermined amount of a sample mixed therein and (ii) measuring the MALDI mass spectra obtained in step (i) for a value (ion signal ratio) obtained by dividing sample ion signal strength by matrix ion signal strength.
A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness. A different set of processing modules may be selected for a particular disease type (e.g. such as cancer) to be diagnosed. The system may be used to identify biomaterials such as bacteria, virus, and fungi from body fluids like blood, urine, and saliva and other cells.
Methods are described for improving reproducibility of mass spectrum and quantitative analysis method using the same. More particularly, methods for improving reproducibility of a mass spectrum of a chemical compound, wherein temperatures of an ion generation reaction are controlled to be the same with each other, or wherein spectra of which temperature of ion generation reaction are the same with each other are selected from mass spectra of a chemical compound are described. In addition, methods for measuring an equilibrium constant of a proton transfer reaction between a matrix and an analyte at a certain temperature, for obtaining a calibration curve for quantitative analysis, and for quantitative analysis of an analyte by using mass spectra area described.
An apparatus for processing a sample using microwaves comprises: a reaction vessel comprising a chamber which accommodates a refrigerant and a sample and an injection port through which a gas is injected; a microwave source which irradiates microwaves into the chamber; a connector which carries the gas injected through the injection port; and a gas supplier which is located in the chamber and injects the gas carried by the connector to a refrigerant in the chamber. The connector may comprise a gas carrying portion located above the level of the refrigerant in the chamber.
C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
G01N 1/44 - Traitement d'échantillons mettant en œuvre un rayonnement, p. ex. de la chaleur
B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage utilisant des radiations électromagnétiques
17.
APPARATUS AND METHOD FOR PROCESSING SAMPLE USING MICROWAVE
An apparatus for processing a sample using microwaves comprises: a reaction vessel comprising a chamber which accommodates a refrigerant and a sample and an injection port through which a gas is injected; a microwave source which irradiates microwaves into the chamber; a connector which carries the gas injected through the injection port; and a gas supplier which is located in the chamber and injects the gas carried by the connector to a refrigerant in the chamber. The connector may comprise a gas carrying portion located above the level of the refrigerant in the chamber.
KOREA BASIC SCIENCE INSTITUTE (République de Corée)
ASTA CO., LTD. (République de Corée)
Inventeur(s)
Choi, Myoung Choul
Choi, Sang Hwan
Lee, Se Gyu
Lee, Jeong Min
Kim, Yang Sun
Abrégé
An ion regulator for a mass spectrometer may include: a first extraction lens having a first hole through which ions can pass; and a second extraction lens electrically isolated from the first extraction lens and having a second hole which is aligned with the first hole so that the ions passing through the first hole can pass therethrough. The surface of the first hole may be inclined with respect to the moving direction of the ions. Use of the ion regulator will simplify the overall structure of a mass spectrometer and control parameters therefor, and will allow the development of a reliable and efficient compact mass spectrometer.
The present invention relates to a matrix solution for MALDI imaging and a method for measuring the MALDI imaging of biomolecules using the same. The matrix solution according to the invention can make an image of the distribution and density of specific biomolecules through color images by easily extracting the specific biomolecules present in a biological tissue segment to be analyzed. herefore, the mass of the biomolecules can be measured very accurately.
G01N 27/62 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'ionisation des gaz, p. ex. des aérosolsRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant les décharges électriques, p. ex. l'émission cathodique
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
B01D 59/44 - Séparation par spectrographie de masse
H01J 49/26 - Spectromètres de masse ou tubes séparateurs de masse
20.
Sample plate for glycoprotein analysis by MALDI mass spectrometry and preparation method of the same
The present invention relates to a sample plate for matrix-assisted laser desorption ionization (MALDI) mass spectrometry having a stable glyco-affinity layer of a carboxyalkyl boronic acid or carboxyaryl boronic acid and a preparation method of the sample plate. The sample plate shows excellent selectivity for glycoprotein, and can be easily and cost effectively prepared. The sample plate is useful for glycoprotein analysis by MALDI mass spectrometry.
