The present invention provides a method of treating a disease or condition associated with signalling via the TPO receptor. The method comprises the step of administering an effective amount of a peptidyl TPO receptor antagonist to a subject in need thereof, wherein the peptidyl TPOR receptor antagonist is a cyclic or linear peptidyl compound comprising the following structural formula (I): Xbb-Xaa-Xcc wherein Xbb represents a residue of an amino acid selected from arginine (R) and lysine (K); Xaa represents a residue of an amino acid selected from glutamine (Q), asparagine (N), aspartic acid (D), and glutamic acid (E); Xcc represents a residue of an amino acid selected from tryptophan (W), phenylalanine (F), tyrosine (Y), and histidine (H); or a salt thereof.
A process for modifying a polymeric surface, the process comprising; contacting the polymeric surface with a solution comprising at least one ethylenically unsaturated monomer; and exposing the polymeric surface in contact with the solution to ultra-violet light to provide a graft-polymer of the monomer coated on the polymeric surface.
The present invention relates to a method for the preparation of coated thin-film composite (TFC) membranes on a microporous substrate and their functionalization with polymerizable compounds and optionally additional bio active compounds to yield membranes having antifouling and or anti-bacterial properties. Further aspects of the invention are a polymer coating composition on thin-film composite (TFC) membranethe,a coated functionalized thin-film composite (TFC) membrane on the microporous substrate itself and the use of such membranes in water purification systems which may be exposed to microbial contamination.
Provided is a UV polymerization method for the preparation of coated thin-film composite (TFC) membranes on a microporous substrate with specific acrylic monomers and optionally additional bio active compounds to yield membranes having antifouling and/or anti-bacterial properties. Further aspects of the present invention are a polymer coating composition on thin-film composite (TFC) membranes, a coated thin-film composite (TFC) membrane on the microporous substrate itself and the use of such membranes in water purification systems which may be exposed to microbial contamination.
A degradable polyolefin composition comprising a metal containing prodegradant selected from the group consisting of transition metal salts, photoactive metal oxide prodegradants and mixtures thereof and alkoxylated ethylenically saturated non-ionic surfactant.
C08L 23/00 - Compositions contenant des homopolymères ou des copolymères d'hydrocarbures aliphatiques non saturés ne possédant qu'une seule liaison double carbone-carboneCompositions contenant des dérivés de tels polymères
C08K 5/09 - Acides carboxyliquesLeurs sels métalliquesLeurs anhydrides
C08K 5/098 - Sels métalliques d'acides carboxyliques
The invention relates to a process for increasing the melt flow index of a propylene polymer, the process comprising melt mixing the propylene polymer in the presence of aqueous hydrogen peroxide.
C08J 3/21 - Formation de mélanges de polymères avec des additifs, p. ex. coloration en présence d'une phase liquide le polymère étant prémélangé avec une phase liquide
A working electrode and dye sensitized solar (DSSC) cell having working electrode where the working electrode includes a porous metal foil conductor and a particulate metal oxide layer on the side of the foil for facing incident light and process for preparing the electrode and DSSC.
Oligo- or polyurethane compounds of the formula (I) wherein k and n independently are numbers from 1 to 100, m is from the range 1 -100, (X) is a block of formula (II) and (Y) is a block of the formula (III), (A) is a residue of an aliphatic or aromatic diisocyanate linker, (B) is a residue of a linear oligo- or polysiloxane containing alkanol end groups, and optionally further containing one or more aliphatic ether moieties, and (C) is an aromatic oligo- or polysulfone block, may advantageously be used as anti-adhesion additives in polymer compositions e.g. for membranes; related oligo- or polyurethanes wherein m is 0 are especially suitable for the preparation of antimicrobial water separation membranes.
Disclosed is a process for preparing an antimicrobial article, wherein a silver colloid is formed in situ as a result of the components employed. The process comprises the steps of (i) providing a liquid, which contains a soluble polar polymer in a solvent selected from certain polar organic solvents; (ii) adding a silver salt selected from alpha-functionalized silver carboxylates to said liquid; (iii) allowing the mixture to react with formation of a silver colloid; and (iv) separating the solvent from the mixture and forming of the antimicrobial article. The antimicrobial articles thus obtained may be sheets, films, fibres, coating layers, and especially membranes like a semipermeable membrane for ultrafiltration, water separation or gas separation.
B01D 71/82 - Matériaux macromoléculaires non prévus spécifiquement dans un seul des groupes caractérisés par la présence de groupes déterminés, p. ex. introduits par un post-traitement chimique
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
A new composite comprises (a) 10.1 -99.9 % by weight of elemental Ag and (b) 0.1 -89.9 % by weight of ZnO, wherein the sum of (a) and (b) makes 90 % or more by weight of the composite and wherein the elemental Ag has a primary particle size of 10-200 nm and/or the ZnO has a primary particle size of 0.1 to below 50μm and/or the composite has a particle size distribution of 0.1 - 50 μm and/or a BET surface area of 10-100 m2/g. The novel composite may be obtained by the steps (i) mixing a first mixture of at least one Ag-salt with a second mixture of at least one Zn-salt thereby forming a third mixture of Ag- and Zn-salts, (ii) adding the third mixture to a mixture of a carbonate source, (iii) co-precipitating of the Ag- and Zn-carbonates formed in step (ii), (iv) washing of the Ag- and Zn-carbonates and (v) thermal decompositing of the Ag- and Zn-carbonates. The novel composites are useful to impart antimicrobial properties to surfaces, articles or bulk compositions, especially to membrane systems for gas- or water separation.
B22F 9/30 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par un procédé chimique avec décomposition de mélanges métalliques, p. ex. par pyrolyse
B82B 1/00 - Nanostructures formées par manipulation d’atomes ou de molécules, ou d’ensembles limités d’atomes ou de molécules un à un comme des unités individuelles
B82B 3/00 - Fabrication ou traitement des nanostructures par manipulation d’atomes ou de molécules, ou d’ensembles limités d’atomes ou de molécules un à un comme des unités individuelles
The invention relates to biopolymer-gel based depot systems for prolonged and/or controlled release delivery of biologically active agents, methods for the manufacture of the biopolymer based gel-depots which include a biologically active agent, and uses of such biopolymer gel-depots in therapy. The biopolymer-gel based depot systems comprise a biocompatible polyaminosaccharide and/or protein; a biocompatible phosphate and/or sulphonamide compound; a biologically active agent; an aqueous insoluble alkaline earth metal phosphate; and a biocompatible glycan and/or proteoglycan.
The present invention relates to a method for controlling evaporation from a body of water. The method of the invention uses a water insoluble compound and a water soluble polymer, which interact with each other by non-covalent bonding interactions.
B01J 19/16 - Prévention de l'évaporation ou de l'oxydation de liquides non métalliques par emploi d'une couche flottante, p. ex. de microbilles
C09K 3/18 - Substances non couvertes ailleurs à appliquer sur des surfaces pour y minimiser l'adhérence de la glace, du brouillard ou de l'eauSubstances antigel ou provoquant le dégel pour application sur des surfaces
The present invention relates to the preparation of clickable thin film composite (TFC) polyamide membranes, i.e. either azide functionalized, alkyne functionalized or both, that allow a very simple and easy surface modification of the membrane via click chemistry. Further aspects of the invention are such membranes per se, a process for the subsequent modification of the thin film composite polyamide membrane surface using click chemistry to yield membranes having new chemical and physical properties, e.g. antifouling and/or antibacterial properties.
A method of fabricating microstructured cell culture devices comprising: providing a mold surface on which the microstructure is to be formed in an injection mold; subjecting the mold surface to pulsed laser etching to form the inverse pattern of the microstructure defining the walls of an array of micro-wells; forming an injection mold cavity defined by internal surfaces comprising the mold surface; injecting a solidifiable polymeric material into the injection mold to form a solidified polymeric cell culture device having the array of micro-wells formed therein; and removing the cell culture device from the mold.
The present invention relates to a polymer brush in the form of an electrospun polymer fibre having grafted to its surface a plurality of living polymer chains that constitute the brush layer.
D06M 14/10 - Polymérisation par greffage de monomères, contenant des liaisons non saturées carbone-carbone, sur des fibres, fils, filés, tissus ou articles fibreux faits de ces matières sur des matières d'origine synthétique de composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
C08F 257/02 - Composés macromoléculaires obtenus par polymérisation de monomères sur des polymères de monomères aromatiques tels que définis dans le groupe sur des polymères de styrène ou de styrène substitué par des groupes alkyle
D06M 14/28 - Polymérisation par greffage de monomères, contenant des liaisons non saturées carbone-carbone, sur des fibres, fils, filés, tissus ou articles fibreux faits de ces matières par énergie ondulatoire ou rayonnement corpusculaire sur des matières d'origine synthétique de composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 27/00 - Matériaux pour prothèses ou pour revêtement de prothèses
D01F 11/06 - Post-traitement chimique de filaments, ou similaires, faits par l’homme, pendant leur fabrication de polymères synthétiques à partir de composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
The present invention relates to a method of preparing RAFT, ATRP or NMRP functionalized thin film composite (TFC) polyamide membranes on a microporous substrate. A further aspect of the invention is the subsequent modification of the thin film composite polyamide membrane by controlled free radical polymerization (CFRP) to yield membranes having new chemical and physical properties, e.g. antifouling and/or antibacterial properties. Further aspects of the invention are the functionalized thin film composite (TFC) polyamide membranes on the microporous substrate itself and the membranes modified by controlled free radical polymerization.
C08F 2/38 - Polymérisation utilisant des régulateurs, p. ex. des agents d'arrêt de chaîne
C08F 293/00 - Composés macromoléculaires obtenus par polymérisation sur une macromolécule contenant des groupes capables d'amorcer la formation de nouvelles chaînes polymères rattachées exclusivement à une ou aux deux extrémités de la macromolécule de départ
C08L 77/00 - Compositions contenant des polyamides obtenus par des réactions créant une liaison amide carboxylique dans la chaîne principaleCompositions contenant des dérivés de tels polymères
This invention relates to patterning metal oxide layers by atomic layer deposition (ALD) on substrates used in the fabrication of dye-sensitised solar cells (DSSC).
The present invention relates to alkoxyamine fuctionalized polysulfones, a process for the functionalization of polysulfones with nitroxide initiators and subsequent nitroxide-mediated radical polymerizations to yield polysulfone-graft-copolymers, e.g polysulfone-graft-poly-4- vinylbenzylchloride copolymer. Further aspects of the invention are the polysulfone-graft- copoolymers itself and the use of such polysulfone-graft-copolymers as membranes.
The present invention discloses the preparation of antimicrobial membranes by inclusion of low leaching, control release silver-based antimicrobial additives as described in claim 1 into the polymer matrix and forming this into a semipermeable membrane. The antimicrobial agents protect the membrane system against bacterial and/or algal decay and assist in maintaining a high efficiency of the membrane filtration process.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
A method of controlling the degradation of a polymeric film to cause the film to degrade after an intended useful life time includes providing a polymeric film comprising a polymer and prodegradant for the polymer adapted to be activated on irradiation with a controlled dosage of electromagnetic radiation, activating one or more sources of artificial radiation adapted to emit electromagnetic radiation and irradiating at least part of the polymeric film with the artificial radiation. The electromagnetic radiation comprises wavelengths less than about 400 nm. A system for predisposing a polymeric film containing a prodegradant to degrade after an intended service life includes one or more sources of artificial radiation and an irradiation controller, together with a film dispenser dispensing film into the irradiation zone.
C08J 11/10 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation
C08K 5/09 - Acides carboxyliquesLeurs sels métalliquesLeurs anhydrides
The present invention relates to a dye sensitized solar cell comprising a semiconductor formed of a particulate metal oxide, a dye adsorbed onto the semiconductor wherein the semiconductor interface with the dye is formed by atomic layer deposition (ALD) of asemiconductor material onto the particulate metal oxide.
A combined RAFT/ROP process in one-step for the preparation of a graft copolymer having a backbone built-up from repeating units derived by polymerization of free-radically polymerizable monomers comprising vinylic monomers, and polyester side chains grafted to said backbone derived by ring-opening polymerization of cyclic ester compounds; said process comprising reacting a mixture of : (a) one or more vinylic monomers, optionally in combination with other monomers susceptible to free-radical polymerization, wherein at least one of said vinylic monomers comprises a (free) hydroxyl group; (b) a thiocarbonylthio compound as chain transfer agent; (c) one or more cyclic esters, which is/are susceptible to a ring-opening polymerization; and (d) a system effective for initiating the ring-opening polymerization of the one or more cyclic esters; and reacting said mixture in an inert solvent at a temperature of more than 80 °C under exclusion of oxygen to form the graft copolymer.
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