Produits et services

(1) Pharmaceutical preparations, namely, pharmaceutical preparations for the relief of pain; pharmaceutical preparation, namely, bronchodilator; pharmaceutical preparations for the treatment of disorders of the eye; pharmaceutical preparations, namely, biopharmaceutical preparations, namely, biopharmaceuticals for the treatment of cancer; pharmaceutical preparations for use in immunotherapies; anti-emetic preparations; anaesthetic, pre-anaesthetic and analgesic pharmaceutical preparations, namely, anaesthetics for surgical use, general anaesthetics, inhalant anaesthetics, local anaesthetics, topical anaesthetics; inhalable anaesthetic, pre-anaesthetic and analgesic pharmaceutical preparations; bronchodilating pharmaceutical preparations; pharmaceutical preparations for the treatment of insomnia and sleep disorders; opioid antagonist pharmaceutical preparations; pharmaceutical preparations for the treatment of opioid overdose; nasal spray preparations; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders, mood disorders, oppositional defiance disorder, conduct disorder, learning disabilities, autism spectrum disorder, tic disorders, binge eating and obsessive eating disorders, anxiety disorders, substance abuse disorders, depression, psychosis; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders; pharmaceutical preparations for the treatment of nerve diseases and disorders, namely, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, cerebral palsy and multiple sclerosis; pharmaceutical preparations for the treatment of psychiatric diseases and disorders, namely, mood disorders, anxiety disorders, cognitive disorders, schizophrenia and bipolar disorders; ophthalmic pharmaceutical preparations; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer; pharmaceutical preparations for the treatment of oncological diseases and disorders; pharmaceutical preparations for use in oncology; pharmaceutical preparations for the treatment of chronic pain; pharmaceutical anti-allergic preparations and substances; pharmaceutical preparations for the treatment of anaphylactic reactions; drug delivery agents in the form of films that facilitate the delivery of pharmaceutical preparations; pharmaceutical preparations for the treatment of osteoarthritic pain (2) Inhalers for therapeutic use; inhalers for medical purposes sold empty; medical devices and apparatus for the delivery of anaesthetic, pre-anaesthetic and analgesic substances (1) Wholesale and online sales of pharmaceutical preparations, and medical devices and supplies (2) Custom manufacture of pharmaceutical preparations, and medical devices and supplies (3) Research and development in the fields of pharmaceutical preparations, and medical devices and supplies (4) Providing information to health care providers about pharmaceutical preparations; providing information about the treatment of human diseases and disorders, namely insomnia and sleep disorders, diseases and disorders of the central nervous system, nerve diseases and disorders, psychiatric diseases and disorders, cancer

Produits et services

(1) Pharmaceutical preparation for hematopoietic growth factors; pharmaceutical preparation, namely recombinant human granulocyte colony stimulating factor, for use in stimulating white blood cell production

Produits et services

(1) Pharmaceutical preparations, namely, pharmaceutical preparations for the relief of pain; pharmaceutical preparation, namely, bronchodilator; pharmaceutical preparations for the treatment of disorders of the eye; pharmaceutical preparations, namely, biopharmaceutical preparations, namely, biopharmaceuticals for the treatment of cancer; pharmaceutical preparations for use in immunotherapies; anti-emetic preparations; anaesthetic, pre-anaesthetic and analgesic pharmaceutical preparations, namely, anaesthetics for surgical use, general anaesthetics, inhalant anaesthetics, local anaesthetics, topical anaesthetics; inhalable anaesthetic, pre-anaesthetic and analgesic pharmaceutical preparations; bronchodilating pharmaceutical preparations; pharmaceutical preparations for the treatment of insomnia and sleep disorders; opioid antagonist pharmaceutical preparations; pharmaceutical preparations for the treatment of opioid overdose; nasal spray preparations; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders, mood disorders, oppositional defiance disorder, conduct disorder, learning disabilities, autism spectrum disorder, tic disorders, binge eating and obsessive eating disorders, anxiety disorders, substance abuse disorders, depression, psychosis; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders; pharmaceutical preparations for the treatment of nerve diseases and disorders, namely, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, cerebral palsy and multiple sclerosis; pharmaceutical preparations for the treatment of psychiatric diseases and disorders, namely, mood disorders, anxiety disorders, cognitive disorders, schizophrenia and bipolar disorders; ophthalmic pharmaceutical preparations; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer; pharmaceutical preparations for the treatment of oncological diseases and disorders; pharmaceutical preparations for use in oncology; pharmaceutical preparations for the treatment of chronic pain; pharmaceutical anti-allergic preparations and substances; pharmaceutical preparations for the treatment of anaphylactic reactions; drug delivery agents in the form of films that facilitate the delivery of pharmaceutical preparations; pharmaceutical preparations for the treatment of osteoarthritic pain (2) Inhalers for therapeutic use; inhalers for medical purposes sold empty; medical devices and apparatus for the delivery of anaesthetic, pre-anaesthetic and analgesic substances (1) Wholesale and online sales of pharmaceutical preparations, and medical devices and supplies (2) Custom manufacture of pharmaceutical preparations, and medical devices and supplies (3) Research and development in the fields of pharmaceutical preparations, and medical devices and supplies (4) Providing information to health care providers about pharmaceutical preparations; providing information about the treatment of human diseases and disorders, namely insomnia and sleep disorders, diseases and disorders of the central nervous system, nerve diseases and disorders, psychiatric diseases and disorders, cancer

Produits et services

(1) Pharmaceutical preparations, namely, pharmaceutical preparations for the relief of pain; pharmaceutical preparation, namely, bronchodilator; pharmaceutical preparations for the treatment of disorders of the eye; pharmaceutical preparations, namely, biopharmaceutical preparations, namely, biopharmaceuticals for the treatment of cancer; pharmaceutical preparations for use in immunotherapies; anti-emetic preparations; anaesthetic, pre-anaesthetic and analgesic pharmaceutical preparations, namely, anaesthetics for surgical use, general anaesthetics, inhalant anaesthetics, local anaesthetics, topical anaesthetics; inhalable anaesthetic, pre-anaesthetic and analgesic pharmaceutical preparations; bronchodilating pharmaceutical preparations; pharmaceutical preparations for the treatment of insomnia and sleep disorders; opioid antagonist pharmaceutical preparations; pharmaceutical preparations for the treatment of opioid overdose; nasal spray preparations; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders, mood disorders, oppositional defiance disorder, conduct disorder, learning disabilities, autism spectrum disorder, tic disorders, binge eating and obsessive eating disorders, anxiety disorders, substance abuse disorders, depression, psychosis; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders; pharmaceutical preparations for the treatment of nerve diseases and disorders, namely, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, cerebral palsy and multiple sclerosis; pharmaceutical preparations for the treatment of psychiatric diseases and disorders, namely, mood disorders, anxiety disorders, cognitive disorders, schizophrenia and bipolar disorders; ophthalmic pharmaceutical preparations; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer; pharmaceutical preparations for the treatment of oncological diseases and disorders; pharmaceutical preparations for use in oncology; pharmaceutical preparations for the treatment of chronic pain; pharmaceutical anti-allergic preparations and substances; pharmaceutical preparations for the treatment of anaphylactic reactions; drug delivery agents in the form of films that facilitate the delivery of pharmaceutical preparations; pharmaceutical preparations for the treatment of osteoarthritic pain (2) Inhalers for therapeutic use; inhalers for medical purposes sold empty; medical devices and apparatus for the delivery of anaesthetic, pre-anaesthetic and analgesic substances (1) Wholesale and online sales of pharmaceutical preparations, and medical devices and supplies (2) Custom manufacture of pharmaceutical preparations, and medical devices and supplies (3) Research and development in the fields of pharmaceutical preparations, and medical devices and supplies (4) Providing information to health care providers about pharmaceutical preparations; providing information about the treatment of human diseases and disorders, namely insomnia and sleep disorders, diseases and disorders of the central nervous system, nerve diseases and disorders, psychiatric diseases and disorders, cancer

Produits et services

(1) Pharmaceutical preparations, namely, pharmaceutical preparations for the relief of pain; pharmaceutical preparation, namely, bronchodilator; pharmaceutical preparations for the treatment of disorders of the eye; pharmaceutical preparations, namely, biopharmaceutical preparations, namely, biopharmaceuticals for the treatment of cancer; pharmaceutical preparations for use in immunotherapies; anti-emetic preparations; anaesthetic, pre-anaesthetic and analgesic pharmaceutical preparations, namely, anaesthetics for surgical use, general anaesthetics, inhalant anaesthetics, local anaesthetics, topical anaesthetics; inhalable anaesthetic, pre-anaesthetic and analgesic pharmaceutical preparations; bronchodilating pharmaceutical preparations; pharmaceutical preparations for the treatment of insomnia and sleep disorders; opioid antagonist pharmaceutical preparations; pharmaceutical preparations for the treatment of opioid overdose; nasal spray preparations; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders, mood disorders, oppositional defiance disorder, conduct disorder, learning disabilities, autism spectrum disorder, tic disorders, binge eating and obsessive eating disorders, anxiety disorders, substance abuse disorders, depression, psychosis; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders; pharmaceutical preparations for the treatment of nerve diseases and disorders, namely, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, cerebral palsy and multiple sclerosis; pharmaceutical preparations for the treatment of psychiatric diseases and disorders, namely, mood disorders, anxiety disorders, cognitive disorders, schizophrenia and bipolar disorders; ophthalmic pharmaceutical preparations; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer; pharmaceutical preparations for the treatment of oncological diseases and disorders; pharmaceutical preparations for use in oncology; pharmaceutical preparations for the treatment of chronic pain; pharmaceutical anti-allergic preparations and substances; pharmaceutical preparations for the treatment of anaphylactic reactions; drug delivery agents in the form of films that facilitate the delivery of pharmaceutical preparations; pharmaceutical preparations for the treatment of osteoarthritic pain (2) Inhalers for therapeutic use; inhalers for medical purposes sold empty; medical devices and apparatus for the delivery of anaesthetic, pre-anaesthetic and analgesic substances (1) Wholesale and online sales of pharmaceutical preparations, and medical devices and supplies (2) Custom manufacture of pharmaceutical preparations, and medical devices and supplies (3) Research and development in the fields of pharmaceutical preparations, and medical devices and supplies (4) Providing information to health care providers about pharmaceutical preparations; providing information about the treatment of human diseases and disorders, namely insomnia and sleep disorders, diseases and disorders of the central nervous system, nerve diseases and disorders, psychiatric diseases and disorders, cancer

Produits et services

(1) Pharmaceutical preparations, namely, pharmaceutical preparations for the relief of pain; pharmaceutical preparation, namely, bronchodilator; pharmaceutical preparations for the treatment of disorders of the eye; pharmaceutical preparations, namely, biopharmaceutical preparations, namely, biopharmaceuticals for the treatment of cancer; pharmaceutical preparations for use in immunotherapies; anti-emetic preparations; anaesthetic, pre-anaesthetic and analgesic pharmaceutical preparations, namely, anaesthetics for surgical use, general anaesthetics, inhalant anaesthetics, local anaesthetics, topical anaesthetics; inhalable anaesthetic, pre-anaesthetic and analgesic pharmaceutical preparations; bronchodilating pharmaceutical preparations; pharmaceutical preparations for the treatment of insomnia and sleep disorders; opioid antagonist pharmaceutical preparations; pharmaceutical preparations for the treatment of opioid overdose; nasal spray preparations; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders, mood disorders, oppositional defiance disorder, conduct disorder, learning disabilities, autism spectrum disorder, tic disorders, binge eating and obsessive eating disorders, anxiety disorders, substance abuse disorders, depression, psychosis; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders; pharmaceutical preparations for the treatment of nerve diseases and disorders, namely, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, cerebral palsy and multiple sclerosis; pharmaceutical preparations for the treatment of psychiatric diseases and disorders, namely, mood disorders, anxiety disorders, cognitive disorders, schizophrenia and bipolar disorders; ophthalmic pharmaceutical preparations; pharmaceutical preparations for use in ophthalmology; pharmaceutical preparations for the prevention and treatment of cancer; pharmaceutical preparations for the treatment of oncological diseases and disorders; pharmaceutical preparations for use in oncology; pharmaceutical preparations for the treatment of chronic pain; pharmaceutical anti-allergic preparations and substances; pharmaceutical preparations for the treatment of anaphylactic reactions; drug delivery agents in the form of films that facilitate the delivery of pharmaceutical preparations; pharmaceutical preparations for the treatment of osteoarthritic pain (2) Inhalers for therapeutic use; inhalers for medical purposes sold empty; medical devices and apparatus for the delivery of anaesthetic, pre-anaesthetic and analgesic substances (1) Wholesale and online sales of pharmaceutical preparations, and medical devices and supplies (2) Custom manufacture of pharmaceutical preparations, and medical devices and supplies (3) Research and development in the fields of pharmaceutical preparations, and medical devices and supplies (4) Providing information to health care providers about pharmaceutical preparations; providing information about the treatment of human diseases and disorders, namely insomnia and sleep disorders, diseases and disorders of the central nervous system, nerve diseases and disorders, psychiatric diseases and disorders, cancer

Produits et services

(1) Natural and non-prescription health care products, namely, fatty acids for use as additives to foods and beverages for medical purposes (2) Cleansers, namely, skin cleansers; cleansers, namely, non-medicated wound cleansers; non-medicated skin creams, lotions, ointments and salves, non-medicated diaper rash cream, non-medicated anti-itch and dry-skin creams, cosmetic creams, lotions, ointments and salves for the face, hands and body, sunscreen preparations (3) Non-prescription pharmaceutical preparations for the treatment of minor wounds, cuts, boils, abrasions, skin tears and sores, burns, grazes, itching and irritation, rashes; non-prescription pharmaceutical preparations for veterinary medicine for the treatment of minor wounds, cuts, boils, abrasions, skin tears and sores, burns, grazes, itching and irritation, rashes; herbal supplements for general health and well-being; natural and non-prescription health care products, namely, amino acid dietary and nutritional supplements, fatty acid dietary and nutritional supplements, vitamin and mineral supplements, probiotic dietary and nutritional supplements; natural and non-prescription health care products, namely, amino acids, vitamins, minerals and probiotics for use as additives to foods and beverages for medical purposes; natural and nonprescription health care products, namely, dietetic substances adapted for medical purposes, containing amino acids, fatty acids, vitamins, minerals and probiotics; non-prescription laxatives; non-prescription pharmaceutical preparations, herbal supplements and natural and non-prescription health care products, namely, preparations, for alleviating constipation, aiding digestion, treating digestive disorders, treating nausea and vomiting, treating motion sickness and seasickness; non-prescription decongestants; nonprescription expectorants; non-prescription antihistamines; non-prescription pharmaceutical preparations, herbal supplements and natural and non-prescription health care products, namely, preparations for treating colds, coughs, nasal and sinus congestion, allergies; wound care products, namely, wound dressings, first aid dressings, pharmaceutical preparations for wounds, medicated cleansers for skin and wounds, adhesive wound closures, topical first aid gels; wound care products, namely, sanitizing wipes, and dressings, cloths and materials impregnated with non-prescription pharmaceutical preparations for use in dressing wounds; non-prescription antiseptics; non-prescription anti-viral preparations; medicated and non-medicated antiseptic solutions; topical anti-viral, anti-bacterial and anti-fungal antiseptics; cleansers, namely topical anti-viral, anti-bacterial and anti-fungal cleansers for skin and wounds, mouth cavity cleansers; medicated and non-medicated wipes and bandages for treating wounds; medicated creams, lotions, ointments and salves, namely, antifungal creams, lotions, ointments and salves for medical use, antibiotic creams, lotions, ointments and salves, multi-purpose medicated antibiotic creams, lotions, ointments and salves, medicated creams, lotions, ointments and salves for skin rashes, inflammation and common skin irritations, medicated anti-itch and dry skin creams, lotions, ointments and salves, hydrocortisone creams, lotions, ointments and salves, calamine lotion, hemorrhoidal creams and ointments; germicides; medicated throat sprays and rinses; medicated premoistened feminine towelettes and wipes; medicated feminine hygiene washes (4) Wound care products, namely, thermal packs for first aid purposes, cooling pads for first aid purposes (1) Research and development in the field of non-prescription pharmaceutical preparations, herbal supplements, and natural and non-prescription health care products

Produits et services

(1) Natural and non-prescription health care products, namely, fatty acids for use as additives to foods and beverages for medical purposes (2) Cleansers, namely, skin cleansers; cleansers, namely, non-medicated wound cleansers; non-medicated skin creams, lotions, ointments and salves, non-medicated diaper rash cream, non-medicated anti-itch and dry-skin creams, cosmetic creams, lotions, ointments and salves for the face, hands and body, sunscreen preparations (3) Non-prescription pharmaceutical preparations for the treatment of minor wounds, cuts, boils, abrasions, skin tears and sores, burns, grazes, itching and irritation, rashes; non-prescription pharmaceutical preparations for veterinary medicine for the treatment of minor wounds, cuts, boils, abrasions, skin tears and sores, burns, grazes, itching and irritation, rashes; herbal supplements for general health and well-being; natural and non-prescription health care products, namely, amino acid dietary and nutritional supplements, fatty acid dietary and nutritional supplements, vitamin and mineral supplements, probiotic dietary and nutritional supplements; natural and non-prescription health care products, namely, amino acids, vitamins, minerals and probiotics for use as additives to foods and beverages for medical purposes; natural and nonprescription health care products, namely, dietetic substances adapted for medical purposes, containing amino acids, fatty acids, vitamins, minerals and probiotics; non-prescription laxatives; non-prescription pharmaceutical preparations, herbal supplements and natural and non-prescription health care products, namely, preparations, for alleviating constipation, aiding digestion, treating digestive disorders, treating nausea and vomiting, treating motion sickness and seasickness; non-prescription decongestants; nonprescription expectorants; non-prescription antihistamines; non-prescription pharmaceutical preparations, herbal supplements and natural and non-prescription health care products, namely, preparations for treating colds, coughs, nasal and sinus congestion, allergies; wound care products, namely, wound dressings, first aid dressings, pharmaceutical preparations for wounds, medicated cleansers for skin and wounds, adhesive wound closures, topical first aid gels; wound care products, namely, sanitizing wipes, and dressings, cloths and materials impregnated with non-prescription pharmaceutical preparations for use in dressing wounds; non-prescription antiseptics; non-prescription anti-viral preparations; medicated and non-medicated antiseptic solutions; topical anti-viral, anti-bacterial and anti-fungal antiseptics; cleansers, namely topical anti-viral, anti-bacterial and anti-fungal cleansers for skin and wounds, mouth cavity cleansers; medicated and non-medicated wipes and bandages for treating wounds; medicated creams, lotions, ointments and salves, namely, antifungal creams, lotions, ointments and salves for medical use, antibiotic creams, lotions, ointments and salves, multi-purpose medicated antibiotic creams, lotions, ointments and salves, medicated creams, lotions, ointments and salves for skin rashes, inflammation and common skin irritations, medicated anti-itch and dry skin creams, lotions, ointments and salves, hydrocortisone creams, lotions, ointments and salves, calamine lotion, hemorrhoidal creams and ointments; germicides; medicated throat sprays and rinses; medicated premoistened feminine towelettes and wipes; medicated feminine hygiene washes (4) Wound care products, namely, thermal packs for first aid purposes, cooling pads for first aid purposes (1) Research and development in the field of non-prescription pharmaceutical preparations, herbal supplements, and natural and non-prescription health care products

Produits et services

(1) Opioid antagonist pharmaceutical preparations; pharmaceutical preparations for the treatment of opioid overdose; nasal spray preparations (1) Providing information in the field of opioid use and overdose; providing information to health care providers about pharmaceutical preparations for the treatment of opioid overdose; providing information to health care providers about pharmaceutical preparations for the treatment of opioid overdose via a website, the Internet or other global communication networks

Produits et services

Pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders, mood disorders, oppositional defiance disorder, conduct disorder, learning disabilities, autism spectrum disorder, tic disorders, binge eating and obsessive eating disorders, anxiety disorders, substance abuse disorders, depression, psychosis. Providing information to health care providers about pharmaceutical preparations, including pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, via a website, the Internet or other global communication networks; providing information to health care providers about pharmaceutical preparations, including pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system.

Produits et services

(1) Pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders, mood disorders, oppositional defiance disorder, conduct disorder, learning disabilities, autism spectrum disorder, tic disorders, binge eating and obsessive eating disorders, anxiety disorders, substance abuse disorders, depression, psychosis (1) Providing information to health care providers about pharmaceutical preparations, including pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, via a website, the Internet or other global communication networks; providing information to health care providers about pharmaceutical preparations, including pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system

Produits et services

(1) Pharmaceutical preparation, namely an analgesic administered transdermally via patches that adhere to the skin

Produits et services

(1) pharmaceutical substances and preparations for the treatment of pain

Produits et services

(1) pharmaceutical substances and preparations for the treatment of pain

Produits et services

(1) pharmaceutical substances and preparations for the treatment of pain

Produits et services

(1) Preparation for the relief of pain.

Abrégé

There is described, inter alia, a coated bead comprising: (a) a granule; (b) a first layer coated over the granule, the first layer comprising a first amount of an active pharmaceutical ingredient comprising a central nervous system stimulant; and (c) a second layer coated over the first layer, the second layer being present in an amount sufficient to substantially delay release of the active pharmaceutical ingredient in the first layer until after the coated bead reaches a distal intestine portion of a subject to whom the coated bead is administered; and (d) the third layer coated over the second layer, the third layer comprising a second amount of the active pharmaceutical ingredient, the third layer being configured to permit substantially immediate release of the active pharmaceutical ingredient comprised therein. Embodiments related to a solid oral pharmaceutical composition are also described.

Classes IPC  ?

• A61K 9/56 - Revêtements organiques
• A61K 31/4458 - Pipéridines non condensées, p. ex. pipérocaïne substituées uniquement en position 2, p. ex. méthylphénidate
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• C07D 211/34 - Composés hétérocycliques contenant des cycles pyridiques hydrogénés, non condensés avec d'autres cycles avec uniquement des atomes d'hydrogène et de carbone liés directement à l'atome d'azote du cycle ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes de carbone du cycle avec des radicaux hydrocarbonés, substitués par des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile

Abrégé

There is described a method of reducing drug liking a subject comprising the step of administering to the subject an oral pharmaceutical composition comprising: (i) hydromorphone or a pharmaceutically acceptable salt thereof, and (ii) naloxone or a pharmaceutically acceptable salt thereof, wherein the oral pharmaceutical composition comprising (i) and (ii) in a weight ratio equal to or less than about 4:1. There is also described use of an oral pharmaceutical composition comprising: (i) hydromorphone or a pharmaceutically acceptable salt thereof, and (ii) naloxone or a pharmaceutically acceptable salt thereof, wherein the oral pharmaceutical composition comprising (i) and (ii) in a weight ratio equal to or less than about 4:1, for reducing drug liking in a subject. The present inventors have conducted clinical studies from which it can be concluded that that drug liking in opioid abusers can be reduced when the weight ratio of (i) and (ii) in an intravenous composition is equal to or less than about 4:1. Based on the these clinical studies, the present inventors have established a reasonable inference that similar results would be obtained in the case of oral pharmaceutical compositions having a corresponding weight ratio of (i) and (ii) - i.e., if such an oral composition were to be abused by extraction of (i) and (ii) therefrom, the resulting extraction composition would behave in a similar manner as the intravenous compositions used in the clinical studies reported herein.

Classes IPC  ?

• A61K 31/485 - Dérivés du morphinane, p. ex. morphine, codéine
• A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
• A61P 25/04 - Analgésiques centraux, p. ex. opioïdes
• A61P 25/36 - Médicaments pour le traitement des troubles du système nerveux des états d'abus ou de dépendance aux opiacés
• C07D 489/02 - Composés hétérocycliques contenant des systèmes cycliques 4 aH-8, 9 c-imino-éthano-phénantro [4, 5-b, c, d] furanne, p. ex. dérivés d'époxy-4, 5 morphinane de formule avec des atomes d'oxygène liés en position 3 et 6, p. ex. morphine, morphinone
• C07D 489/08 - Atome d'oxygène

Produits et services

Pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders, mood disorders, oppositional defiance disorder, conduct disorder, learning disabilities, autism spectrum disorder, tic disorders, binge eating and obsessive eating disorders, anxiety disorders, substance abuse disorders, depression, psychosis. Providing information to health care providers about pharmaceutical preparations, including pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, via a website, the Internet or other global communication networks; providing information to health care providers about pharmaceutical preparations, including pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system.

Produits et services

(1) Pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system; pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, namely, attention deficit disorder, attention deficit hyperactivity disorder, hyperactivity, cognitive impairment disorders. (1) Providing information to health care providers about pharmaceutical preparations, including pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system, via a website, the Internet or other global communication networks; providing information to health care providers about pharmaceutical preparations, including pharmaceutical preparations for the treatment of diseases and disorders of the central nervous system

Produits et services

(1) Pharmaceutical preparations for the relief of pain. (1) Providing information to health care providers about pharmaceutical preparations, including pharmaceutical preparations for the relief of pain, via a website, the Internet or other global communication networks; providing information to health care providers about pharmaceutical preparations, including pharmaceutical preparations for the relief of pain.

Abrégé

Disclosed is a prolonged release pharmaceutical dosage form comprising a plurality of coated beads, each comprising a granule, a first layer coated on the granule comprising hydromorphone, naloxone, an antioxidant compound and a chelatmg compound; and a second layer coated on the first layer comprising a prolonged release agent. The dosage form has improved stability and dissolution properties. Also disclosed is the use of a combination of an antioxidant, such as sodium metabisulfite, and a chelatmg agent, such as EDTA, to improve the stability and/or dissolution properties of a prolonged release dosage form comprising hydromorphone and naloxone.

Classes IPC  ?

• A61K 9/52 - Préparations en capsules, p. ex. de gélatine, de chocolat du type à libération prolongée ou discontinue
• A61K 31/485 - Dérivés du morphinane, p. ex. morphine, codéine
• A61K 47/02 - Composés inorganiques
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés

Produits et services

(1) Pain-relief tablets for oral consumption formed by a process that hardens the tablets, making them resistant to crushing; pharmaceutical preparations for the relief of pain in the form of tablets formed by a process that hardens the tablets, making them resistant to crushing. (1) Providing information to health care providers about pharmaceutical preparations, including pharmaceutical preparations for the relief of pain, via a website, the Internet or other global communication networks; providing information to health care providers about pharmaceutical preparations, including pharmaceutical preparations for the relief of pain.

Produits et services

(1) Preparation for the relief of pain.

Abrégé

An oral once-daily pramipexole formulation, comprising an immediate-release component and a controlled-release component, is provided wherein in preferred embodiments, both the immediate-release component and the controlled-release component comprise pramipexole The formulation is preferably in the form of a coated bead A method of manufacturing said formulation is also provided.

Classes IPC  ?

• A61K 31/428 - Thiazoles condensés avec des carbocycles
• A61J 3/07 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de capsules ou de petits conteneurs similaires à absorber par voie buccale
• A61K 9/54 - Préparations en capsules, p. ex. de gélatine, de chocolat du type à libération prolongée ou discontinue contenant des particules distinctes avec des revêtements de différentes épaisseurs ou de différents matériaux
• A61P 25/14 - Médicaments pour le traitement des troubles du système nerveux pour traiter les mouvements anormaux, p. ex. chorée, dyskinésie
• A61P 25/16 - Antiparkinsoniens

Produits et services

(1) Tablets for oral consumption formed by a process that hardens the tablets, making them resistant to crushing; pharmaceutical preparations for the relief of pain in the form of tablets formed by a process that hardens the tablets, making them resistant to crushing.

Produits et services

(1) Pharmaceutical preparations, namely ophthalmic preparations for the treatment of glaucoma.

Produits et services

(1) Analgesic preparation for the relief of pain and preparation for the relief of opioid-induced constipation.

Produits et services

(1) Pharmaceutical preparations, namely, ophthalmic preparations for the treatment of glaucoma.

Produits et services

(1) Analgesic preparation for the relief of pain.

Produits et services

(1) Pellets or beads consisting of multiple layers of drug and drug release-controlling excipients, which are encapsulated for pharmaceutical purposes.

Produits et services

(1) Opioid pharmaceutical preparation for relief of pain, in capsule or tablet form.

Produits et services

(1) Pharmaceutical preparation, namely an analgesic administered transdermally via patches that adhere to the skin.

Produits et services

(1) Pharmaceutical preparation for relief of pain, in capsule or tablet form.

Produits et services

(1) Pharmaceutical preparation for the relief of pain, in capsule or tablet form.

Produits et services

(1) Research and development, production and distribution, sales of pharmaceuticals.

Produits et services

(1) Central nervous system (CNS) stimulant.

Produits et services

(1) Analgesic preparation.

Produits et services

(1) Preparation for relief of pain.

Produits et services

(1) Analgesic preparations.

Produits et services

(1) Pharmaceuticals, namely, a controlled-release system used as an ingredient in pharmaceutical preparations.

Produits et services

(1) Preparation for relief of pain.

Produits et services

(1) Analgesic preparation.

Produits et services

(1) Pharmaceutical preparation, namely, bronchodilator.

Produits et services

(1) Pharmaceutical specialties for human and veterinary use, namely, bronchodilators.

Produits et services

(1) Analgesic preparation.

Produits et services

(1) Preparation for relief of pain.

Produits et services

(1) Ophthalmic preparations.

Produits et services

(1) Controlled release delivery composition for use as a component of pharmaceutical preparations.

Produits et services

(1) Medical preparation employed as an analgesic, sedative and hypnotic.

Produits et services

(1) Medical preparation employed as an analgesic, sedative and hypnotic.

Produits et services

(1) Medicinal preparation for ophthalmic use.

Produits et services

(1) Pharmaceutical preparations for the treatment of disorders of the eye.

Produits et services

(1) Pharmaceutical product, namely narcotic analgesic for severe pain. (2) Pharmaceutical product, namely analgesic.

Produits et services

(1) Human pharmaceutical preparations for bronchitis, rhinitis, sinusitis, respiratory congestion and related conditions.

Produits et services

(1) Medicinal preparation for opthalmic use.

Produits et services

(1) Medicinal preparation for ophthalmic use.

Produits et services

(1) A pharmaceutical preparation or soap, namely, a surgical scrub.

Produits et services

(1) A preparation for the removal of ear wax.

Produits et services

(1) Laxatives.

Produits et services

(1) A medical preparation employed as an analgesic, sedative and hypnotic.