A process is provided for obtaining nicotine-depleted tobacco without materially altering the appearance or flavor properties of the tobacco biomass. The method includes a microwave assisted extraction process that uses continuous flow of biomass and solvent through an extractor. The extraction solvent is continuously stripped of nicotine while remaining enriched in other tobacco extractable compounds, including flavor-related components, and is continuously recycled through the extractor. The microwave assisted extraction process includes a low residence time in the extractor, enabling the process to extract nicotine while minimizing physical degradation of the tobacco biomass. The process may also include, for example, methods of recovering and purifying the nicotine extracted from the biomass. A composition of nicotine-depleted tobacco is provided, where the nicotine-depleted tobacco maintains its original appearance and flavor.
An apparatus for extracting an active cannabinoid from a cannabinoid biomass using a microwave-assisted extractor is disclosed. The apparatus includes a controller for receiving a biomass recipe, sensors for collecting data at stages, and an actuator to assist an extractor. A biomass hopper receives a prepared biomass, a removable solvent canister stores solvent, a microwave generator generates microwaves for extracting the active. A slurry mixer mixes the prepared biomass with the solvent to form a slurry. A slurry pump transports the slurry into an extractor tube having a microwave transparent portion for allowing the microwaves to pass and heat the slurry. A removable filter separates an extraction solution from a spent biomass. A solvent evaporation chamber evaporates the solvent. A removable extract collector collects the extract and a removable spent biomass collector collects a spent biomass, obtained after evaporation of the extraction solution.
The application provides a method for decarboxylating acidic carmabinoids into neutral, pharmacologically active, cannabinoids. The method comprises preparing a raw cannabis biomass comprising a plurality of plant matter particles, adding a solvent to the prepared biomass to form a slurry, extracting and separating a quantity of acidic cannabinoids from the slurry, adding a carrier fluid to the extracted quantity of acidic cannabinoids to create a formulated extract, and heating the formulated extract to decarboxylate the quantity of acidic cannabinoids into a quantity of neutral, pharmacologically active, cannabinoids. Also provided is a system for implementing said method and effecting said steps, the system comprising a biomass preparation chamber, a slurry formation chamber, an extraction chamber defined as an extraction apparatus coupled with a heating apparatus, a means of adding a carrier fluid so as to form a formulated extract with extracted acidic cannabinoids, and a decarboxyation chamber.
C07B 63/02 - PurificationSéparation spécialement adaptée aux fins d'isolement des composés organiquesStabilisationEmploi d'additifs par un traitement donnant lieu à une modification chimique
A method of extracting cannabis for usage in food products is disclosed. The method comprises providing a raw biomass of cannabis, which is processed to obtain a prepared cannabis biomass. Slurry may be prepared by adding a solvent to the prepared cannabis biomass. The slurry may be heated in a continuous flow extractor for extracting target compounds. The solvent may be separated from a spent biomass. Further, the solvent may be separated from the target compounds by evaporating the solvent. Further, the desolventized extract may be additionally processed to concentrate extracted active cannabinoid extract fluid. A carrier fluid suitable for use in food may be added to the extracted active cannabinoid extract fluid. Successively, a final formulation of carrier fluid suitable for use in food with active cannabinoids may be obtained. The extracted active cannabinoids and the carrier fluid may be present in a ratio ranging from 0.125% to 3% by weight.
A method of preparing a water-soluble or water-dispersible formulation of cannabinoids is disclosed. The formulation may comprise cannabinoids, terpenes, and flavonoids extracted from a raw cannabis biomass. The formulation can be prepared by dispersing a resinous extract containing the cannabinoids in an aqueous solution to form an emulsion. The aqueous solution can contain complexing agents, which form a complex with the cannabinoids. The aqueous solution containing solubilized cannabinoids can be separated from the emulsion by a liquid-liquid separation process. The obtained aqueous solution containing the solubilized cannabinoids can be subjected to a drying process to form a powdered cannabinoid formulation. The solids may be soluble or dispersible in aqueous-based preparations, such as beverages for consumption.
A system and a method for obtaining a solid form cannabis extracts are disclosed. The method comprises providing a raw biomass material containing a quantity of target compounds for extraction. The raw biomass material may be decarboxylated, ground or pulverized to obtain a prepared cannabis biomass. A slurry may be prepared by adding a solvent to the prepared cannabis biomass. The target components may be extracted from the slurry by processing in a continuous flow extractor. The solvent may be separated from a spent biomass; further, the solvent may be separated from the target components by heating and evaporating the solvent. Successively, the target components may be solidified by a downstream process, such as concentration, separation, isolation, and formulation. In a preferred embodiment, the extract may fully or partially stripped of a solvent and mixed with an excipient before a spray drying process.
Systems and methods for preparing profile-based blends ( e.g., mimicking a plant profile) are provided. Such blends may include compositions having the pharmacologically active compounds in a predetermined proportions or concentrations. The pharmacologically active compounds may include cannabinoids, terpenes, flavonoids, and other components having biological effects that may be present in a cannabis biomass. A desired plant profile may therefore be re-created from any cannabis biomass having the specified components, which may be isolated (in whole or in part) and titrated in accordance with the respective concentrations specified by the plant profile. Such plant profile may therefore allow for mimicry (e.g., taste, biological effects) of any specific plant variety.
A61K 36/00 - Préparations médicinales de constitution indéterminée contenant du matériel provenant d'algues, de lichens, de champignons, ou de plantes, ou leurs dérivés, p. ex. médicaments traditionnels à base de plantes
A23L 33/105 - Extraits de plantes, leurs doublons artificiels ou leurs dérivés
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
A method and apparatus for extracting pharmacologically active ingredients with increased yield and purity from a cannabis biomass is disclosed. The method comprises providing a raw cannabis biomass containing target compounds for extraction. The raw cannabis biomass may be ground or pulverized to obtain a prepared cannabis biomass. Slurry may be prepared by adding a solvent to the prepared cannabis biomass. The solvent may be selected based on different dielectrics and solvent parameter properties. The slurry may be heated in a continuous flow microwave-assisted extraction apparatus to obtain an extract. The microwave-assisted extraction apparatus may include one or more sensor that may monitor the temperature, pressure, and/or residence time of the slurry. Successively, the spent biomass and the extract may be separated from the slurry. The extract may be treated to obtain a final formulation containing the target compounds in sufficiently high yield and high purity. The spent biomass may be processed to yield less than 0.3% concentration of cannabinoids naturally produced by plants.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Chemical additives for use in the manufacture of pharmaceuticals; chemicals for use in the manufacture of solvents; ethanol
(2) Computer software for use in managing and controlling extraction methods for the purpose of isolating cannabis seeds, clones, tissue cultures and marijuana derivatives from dried plant and whole plant materials (1) Development of pharmaceutical, botanical and nutraceutical preparations and medicines; Clinical research in the field of cannabis science and medicine; Design, research and development of advanced plant-cultivation methods and technologies for use in the pharmaceutical, nutraceuticals and food products; Developing technologies to improve plant growth, production and extraction technologies to maximize production of pharmaceutical grade plant extracts; Pharmaceutical research and development of extraction methods for the purpose of isolating cannabis seeds, clones, tissue cultures and marijuana derivatives from dried plant and whole plant materials
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
Produits et services
(1) Microwave apparatus used for the production of gas and liquid phase extracts of plant products, animal products, mineral products, aqueous solutions and other biological material (1) Microwave process used for the production of gas and liquid phase extracts of plant products, animal products, mineral products, aqueous solutions and other biological material
The present invention relates to a process for extracting, purifying and isolating cyclopamine from cyclopamine-containing biomass comprising the steps of contacting cyclopamine-containing organic matter with an extractant (e.g., aqueous extractant) capable of extracting cyclopamine, separating the extracted organic matter from the cyclopamine/extract solution, concentrating the cyclopamine/extract solution leaving a concentrated aqueous solution, contacting the concentrated aqueous solution with an organic extractant capable of selectively extracting cyclopamine from the aqueous phase, concentrating the cyclopamine-containing organic phase, providing an enriched extract containing cyclopamine, separating cyclopamine from the enriched extract using column chromatography, providing at least one fraction containing cyclopamine, and crystallizing select chromatography fractions to provide purified cyclopamine.
C07J 69/00 - Stéroïdes ayant le squelette du cyclopenta[a]hydrophénanthrène modifié par contraction d'un seul cycle par un atome et expansion d'un seul cycle par un atome
C07J 21/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène, ou de l'oxygène ayant un hétérocycle contenant de l'oxygène condensé en spiro avec le squelette du cyclopenta[a]hydrophénanthrène
C07J 43/00 - Stéroïdes normaux ayant un hétérocycle contenant de l'azote non condensé ou condensé en spiro avec le squelette du cyclopenta[a]hydrophénanthrène
09 - Appareils et instruments scientifiques et électriques
Produits et services
computerized microwave apparatus and computer program therefor used in the production of gas and liquid phase extracts of plant products, animal products, mineral products, aqueous solutions and other biological material, not for use in the medical field
