Provided are compounds of Formula I and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
C07D 498/22 - Composés hétérocycliques contenant dans le système condensé au moins un hétérocycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle dans lesquels le système condensé contient au moins quatre hétérocycles
A61K 31/504 - PyridazinesPyridazines hydrogénées formant une partie de systèmes cycliques pontés
A61P 31/14 - Antiviraux pour le traitement des virus ARN
Provided are compounds of Formula I and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
C07D 498/22 - Composés hétérocycliques contenant dans le système condensé au moins un hétérocycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle dans lesquels le système condensé contient au moins quatre hétérocycles
Provided are compounds of Formula (I) and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
Provided are compounds of Formula (I): and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
16 - Papier, carton et produits en ces matières
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Synthetic, natural and biological chemicals used in industry
and science; synthetic, natural and biological chemicals
used in agriculture; synthetic, natural and biological
chemical compounds; synthetic, natural and biological
chemical compounds for use as radiotracers; radiolabelled
compounds for use in regulatory, research and scientific
studies; synthetic, natural and biological chemical
compounds with isotopic labels; synthetic, natural and
biological chemical compounds for research purposes;
chemical libraries; chemical fragment libraries; chemical
reagents; biochemical and biological preparations for use in
industry, science and research; diagnostic preparations;
radioactive elements, isotopes and preparations; chemical
compounds, natural products and biologicals for use in
pharmaceutical research and drug discovery; chemical
compounds, natural products and biologicals being clinical
candidates in pharmaceutical research and drug discovery;
chemical compounds, natural products and biologicals for use
in hit identification, lead generation, optimisation and
development in pharmaceutical research; radiolabelled
ligands and isotopically labelled compounds used in
screening and diagnostic tests; chemical compounds, natural
products and biologicals for use as reference standards of
products, impurities and metabolites in agrochemical,
pharmaceutical veterinary and chemical industries. Pharmaceutical and veterinary preparations; chemical
compounds, natural products and biologicals for use as
pharmaceuticals; diagnostic agents, preparations and
substances for medical purposes. Printed matter; reports, certificates and associated printed
matter for use in pharmaceutical, crop protection and
environmental regulatory submissions; printed matter
relating to scientific, pharmaceutical, medicinal,
pesticidal, chemical and laboratory services. Repurification, namely repurification of stored chemicals,
biological and natural products for others. Scientific and technological services; scientific research,
development and design services; scientific consultancy
services; medicinal chemistry services; pharmaceutical
research services; chemistry services; synthetic chemistry
services; analytical chemistry services; chemical analysis
services, namely natural products extraction, synthesis,
screening and analysis; laboratory services for the
extraction synthesis, screening and analysis of chemical and
biological products; analytical laboratory services;
analysis in the field of good laboratory practice; biology
services; cell biology services; biology services in lead
discovery and optimisation; consultancy services in the
field of drug discovery and evaluation; services in the
field of radiolabelling; consultancy services in the field
of radiolabelling and radiosynthesis; synthesis and analysis
of radiolabelled compounds; services in the field of stable
labelling; services in the field of fragment based drug
discovery, fragment screening and fragment based lead
discovery; synthesis and analysis of chemical compounds;
provision of analytical services to support regulatory
submissions; testing, analysis and evaluation of compounds
for the purposes of certification and for regulatory
submissions; nuclear magnetic resonance spectroscopy;
research into nuclear magnetic resonance spectroscopy;
services in the field of metabolite synthesis; synthesis of
reference standards, process impurities and metabolites;
analysis, research and investigation into chemical
compounds; analysis, research and investigation into
structural elucidation, metabolite identification and
spectral interpretation; anti-counterfeiting services for
chemical compounds; preparation of expert reports and
interpretation relating to scientific research; services in
the provision of compounds and reports for use in research,
development and regulatory studies; scientific data
interpretation services; scientific investigation, research,
development and analysis in the fields of pharmaceuticals,
biotechnology, structural biology, veterinary, animal
health, agriculture, pesticides, insecticides, fungicides,
herbicides, biocides, food and nutrition, household,
personal care, cosmetics and the chemical industry; fragment
screening technology services; electrophoresis services;
capillary electrophoresis services; chemical screening
services; fragment based screening services; services in the
provision of a chemical fragment library; screening services
including development of screens, cell biology and protein
expression; adaptation of technology for the provision of
screening data and information; provision of information and
data in the field of pharmaceutical research and
development; consultancy services in the field of the
creation, generation and preparation of research proposals;
provision of medical chemistry and biology research support;
technical support services; provision of information in the
fields of scientific research and design, chemical
compounds, medical research, medicinal chemistry,
pharmaceutical research, chemistry, synthetic chemistry,
analytical chemistry, biology, screening and analysis;
provision of reports on good laboratory practice;
computational chemistry services; informatics services
including chemo and bio informatics and molecular
informatics services; combinatorial chemistry services;
consultancy in relation to all the aforesaid services.
7.
AFFINITY CAPILLARY ELECTROPHORESIS METHOD FOR ASSESSING A BIOLOGICAL INTERRACTION OF A LIGAND/RECEPTOR PAIR SUCH AS G PROTEIN COUPLED RECEPTOR AND ITS TARGETS AS WELL AS FOR DRUG SCREENING
The invention relates to capillary electrophoresis-based methods for screening compound libraries for affinity ligands, in particular weak-binding ligands.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
The present invention relates to new therapeutic and prophylactic applications of known compounds of general formula (Ia), novel compounds of formula (1a) wherein R3 is methyl, and to compositions comprising them, useful as a medication for the topical therapeutic and prophylactic treatment of dermatological and ophthalmic disorders, rheumatoid arthritis and osteoarthritis.
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61P 27/00 - Médicaments pour traiter les troubles des sens
A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(Based on 44(e) Synthetic, natural and biological chemicals used in industry and science; synthetic, natural and biological chemicals used in agriculture, except fungicides, herbicides and parasitides; synthetic, natural and biological chemical compounds for use as radiotracers; radiolabelled chemical compounds for use in regulatory, research and scientific studies for research purposes; synthetic, natural and biological chemical compounds with isotopic labels for research purposes; synthetic, natural and biological chemical compounds for research purposes; chemical libraries consisting of chemicals for scientific, research and development use; chemical fragment libraries consisting of chemicals for scientific, research and development use; chemical reagents for non-medical purposes; biochemical and biological preparations for use in industry, science and research, except for medical use; diagnostic preparations for scientific, research and development use; radioactive elements, isotopes and preparations for scientific, research and development use, not including therapeutic or diagnostic use; chemical compounds, natural products and biologicals, namely, chemical compounds, natural products in the nature of plant and fungal extracts, compounds derived from such extracts or plant or fungal derived materials, and biological preparations for use as reference standards of products, impurities and metabolites in agrochemical and chemical industries (Based on 44(e) Chemical compounds, natural products and biologicals, namely, chemical compounds, natural products in the nature of plant and fungal extracts, compounds derived from such extracts or plant or fungal derived materials, and biological preparations for use as pharmaceuticals for the treatment of infectious diseases, and diseases and disorders in the field of oncology, hepatology, nephrology, cardiovascular, vascular, respiratory, serology, immunology, haematology, metabolism, neurology and neurodegeneration, neuropathies, pain, gastrointestinal, dermatology, muscoskeletal, central nervous system, endocrinology, hormonal, psychiatric, dementia, urology, obstetrics and gynaecology, ophthalmology, inflammation, odontology, dentistry, cognition, genetic disorders, cerebrovascular, eating disorders, hearing, hypothalamic and pituitary diseases, and sleep disorders; chemical compounds, natural products and biologicals, namely, chemical compounds, natural products in the nature of plant and fungal extracts, compounds derived from such extracts or plant or fungal derived materials, and biological preparations for use in pharmaceutical research and drug discovery; chemical compounds, natural products and biologicals, namely, chemical compounds, natural products in the nature of plant and fungal extracts, compounds derived from such extracts or plant or fungal derived materials, and biological preparations, being clinical candidates for use in pharmaceutical research and drug discovery; chemical compounds, natural products and biologicals, namely, chemical compounds, natural products in the nature of plant and fungal extracts, compounds derived from such extracts or plant or fungal derived materials, and biological preparations for use in hit identification, lead generation, optimisation and development in pharmaceutical research; diagnostic agents, preparations and substances for medical purposes; radiolabelled ligands and isotopically labelled compounds used in screening and diagnostic tests for medical purposes; chemical compounds, natural products and biologicals, namely, chemical compounds, natural products in the nature of plant and fungal extracts, compounds derived from such extracts or plant or fungal derived materials, and biological preparations for use as reference standards of products, impurities and metabolites in pharmaceutical and veterinary industries (Based on 44(e) Printed matter, namely, leaflets, brochures, labels, booklets, manuals, magazines, books, guides, pamphlets, catalogues, journals, newsletters, articles, reports, promotional literature and product guides in the field of science, including chemistry and biology, and in the field of pharmaceutical, medicinal, pesticidal, chemical and laboratory research and development services; presentations in the nature of graphic slides and manuals in the field of science, including chemistry and biology, and in the field of pharmaceutical, medicinal, pesticidal, chemical and laboratory research and development services; printed reports and certificates in the field of pharmaceutical research and development, crop protection and environmental regulatory submissions (Based on 44(e) Services in the provision of chemical and biological compounds for use in research, development and regulatory studies, namely, wholesale distributorship services of chemical compounds; stock management, in the nature of inventory management of chemical compounds (Based on 44(e) Scientific research and development services, and scientific design services in the field of chemical and biological preparation, testing, research and development; scientific consultancy services in the field of chemistry and biology; medicinal chemistry research, development and consultation services; pharmaceutical research services; chemistry research, development and consultation services; synthetic chemistry research, development and consultation services; analytical chemistry research, development and consultation services; natural products chemistry research, development and consultation services; chemical and biological laboratory services; analysis in the field of good laboratory practice; biology research, development and consultation services; cell biology research, development and consultation services; biology research, development and consultation services in lead discovery and optimisation; consultancy services in the field of drug discovery and evaluation; research, development and consultation services in the field of radiolabelling; consultancy services in the field of radiolabelling and radiosynthesis; synthesis and analysis of radiolabelled compounds; research, development and consultation services in the field of stable labelling; research, development and consultation services in the field of fragment based drug discovery, fragment screening and fragment based lead discovery; synthesis and analysis of chemical compounds; provision of analytical chemistry and biology services to support regulatory submissions; provision of certification and analysis of the goods and services of others for regulatory submissions; nuclear magnetic resonance spectroscopy for research, development and laboratory purposes; nuclear magnetic resonance spectroscopy for research, development and laboratory purposes; research, development and consultation services in the field of metabolite synthesis; chemistry and biology services, namely, synthesis of reference standards, process impurities and metabolites; analysis, research and investigation into chemical compounds; analysis, research and investigation into structural elucidation, metabolite identification and spectral interpretation; anti-counterfeiting services for chemical compounds, namely, analysis of chemical and biological compounds for purity measurement; preparation of expert reports and interpretation in the field of chemistry, biology and chemical analysis; services in the provision of information and reports in the field of chemistry, biology and chemical analysis for use in research, development and regulatory studies; scientific data interpretation services; scientific investigation, research, development and analysis in the fields of pharmaceuticals, biotechnology, structural biology, veterinary, animal health, agriculture, pesticides, insecticides, fungicides, herbicides, biocides, food and nutrition, household, personal care, cosmetics and the chemical industry; chemical and biological fragment screening technology research, development and consultation services; electrophoresis research, development and consultation services; capillary electrophoresis research, development and consultation services; chemical and biological screening services for research, development and consultation purposes; fragment based chemical and biological screening services for research, development and consultation purposes; services in the provision of a chemical fragment library, namely, chemical information and materials, and research and development services, provided to research laboratories of others for the design and development of chemical and biological compounds and pharmaceuticals; screening services, namely, development of chemical and biological screens, cell biology and protein expression for research and development purposes; adaptation of technology for the provision of screening data and information; provision of information and data in the field of pharmaceutical research and development; consultancy services in the field of the creation, generation and preparation of research proposals in the field of industrial and scientific research and development; provision of medical chemistry and biology research support; technical support services, namely, providing technical advice; provision of information in the fields of scientific research and design, chemical compounds, medical research, medicinal chemistry, pharmaceutical research, chemistry, synthetic chemistry, analytical chemistry, biology, chemical and biological screening and analysis; provision of reports on good scientific, research and development laboratory practice; computational chemistry research, development and consultation services; informatics services, namely, chemistry and biology informatics and molecular informatics services, namely, data analysis and interpretation; combinatorial chemistry research, development and consultation services; consultancy in relation to all the aforesaid services
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
16 - Papier, carton et produits en ces matières
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Synthetic, natural and biological chemicals used in industry and science; synthetic, natural and biological chemicals used in agriculture; synthetic, natural and biological chemical compounds; synthetic, natural and biological chemical compounds for use as radiotracers; radiolabelled compounds for use in regulatory, research and scientific studies; synthetic, natural and biological chemical compounds with isotopic labels; synthetic, natural and biological chemical compounds for research purposes; chemical libraries; chemical fragment libraries; chemical reagents; biochemical and biological preparations for use in industry, science and research; diagnostic preparations; radioactive elements, isotopes and preparations. Pharmaceutical and veterinary preparations; chemical compounds, natural products and biologicals for use as pharmaceuticals; chemical compounds, natural products and biologicals for use in pharmaceutical research and drug discovery; chemical compounds, natural products and biologicals being clinical candidates in pharmaceutical research and drug discovery; chemical compounds, natural products and biologicals for use in hit identification, lead generation, optimisation and development in pharmaceutical research; diagnostic agents, preparations and substances; radiolabelled ligands and isotopically labelled compounds used in screening and diagnostic tests; chemical compounds, natural products and biologicals for use as reference standards of products, impurities and metabolites in agrochemical, pharmaceutical veterinary and chemical industries. Printed matter; reports, certificates and associated printed matter for use in pharmaceutical, crop protection and environmental regulatory submissions; printed matter relating to scientific, pharmaceutical, medicinal, pesticidal, chemical and laboratory services. Scientific and technological services; scientific research, development and design services; scientific consultancy services; medicinal chemistry services; pharmaceutical research services; chemistry services; synthetic chemistry services; analytical chemistry services; natural products services; laboratory services; analysis in the field of good laboratory practice; biology services; cell biology services; biology services in lead discovery and optimisation; consultancy services in the field of drug discovery and evaluation; services in the field of radiolabelling; consultancy services in the field of radiolabelling and radiosynthesis; synthesis and analysis of radiolabelled compounds; services in the field of stable labelling; services in the field of fragment based drug discovery, fragment screening and fragment based lead discovery; synthesis and analysis of chemical compounds; compound storage, stock management and repurification; laboratory services; provision of analytical services to support regulatory submissions; provision of certification and analysis for regulatory submissions; nuclear magnetic resonance spectroscopy; research into nuclear magnetic resonance spectroscopy; services in the field of metabolite synthesis; synthesis of reference standards, process impurities and metabolites; analysis, research and investigation into chemical compounds; analysis, research and investigation into structural elucidation, metabolite identification and spectral interpretation; anti-counterfeiting services for chemical compounds; preparation of expert reports and interpretation; services in the provision of compounds and reports for use in research, development and regulatory studies; scientific data interpretation services; scientific investigation, research, development and analysis in the fields of pharmaceuticals, biotechnology, structural biology, veterinary, animal health, agriculture, pesticides, insecticides, fungicides, herbicides, biocides, food and nutrition, household, personal care, cosmetics and the chemical industry; fragment screening technology services; electrophoresis services; capillary electrophoresis services; chemical screening services; fragment based screening services; services in the provision of a chemical fragment library; screening services including development of screens, cell biology and protein expression; adaptation of technology for the provision of screening data and information; provision of information and data in the field of pharmaceutical research and development; consultancy services in the field of the creation, generation and preparation of research proposals; provision of medical chemistry and biology research support; technical support services; provision of information in the fields of scientific research and design, chemical compounds, medical research, medicinal chemistry, pharmaceutical research, chemistry, synthetic chemistry, analytical chemistry, biology, screening and analysis; provision of reports on good laboratory practice; computational chemistry services; informatics services including chemo and bio informatics and molecular informatics services; combinatorial chemistry services; consultancy in relation to all the aforesaid services.
