Abrégé

The present invention provides a herbicide composition comprising terbuthylazine, mesotrione and nicosulfuron, and a dispersible oil suspending agent. According to the present invention, aiming at a dosage form of the dispersible oil suspending agent, a safe and environment-friendly auxiliary/solvent is used in cooperation with a specific stabilizer, such that the product has stable quality, is safe and environment-friendly, and has the advantages of being significant in pesticide effect, long in lasting period, high in suspension rate, safe, low in toxicity, etc. The dispersible oil suspending agent prepared in the present invention is a post-emergence herbicide of corn seedlings, is safe to corn crops, and mainly prevents and removes annual and perennial gramineous weeds, nutgrass flatsedge, broadleaf weeds and monocotyledonous weeds. Compared with terbuthylazine, mesotrione and nicosulfuron, the weeding effect is obviously improved, and the improvement of weed resistance is greatly delayed. In the process of applying the dispersible oil suspending agent to corn fields, especially when the dispersible oil suspending agent is used for preventing and removing resistant weeds, the dispersible oil suspending agent has the characteristics of being quick in effect taking, long in lasting period and safe to corn.

Classes IPC  ?

• A01N 47/36 - Urées ou thiourées contenant les groupes N—CO—N ou N—CS—N contenant le groupe N—CO—N lié directement à au moins un hétérocycleLeurs thio-analogues
• A01N 41/10 - SulfonesSulfoxydes
• A01N 43/70 - Diamino-triazines-1,3,5 avec un seul atome d'oxygène, de soufre ou d'halogène ou un seul groupe cyano, thiocyano (—SCN), cyanato (—OCN) ou azido (—N3) lié directement à un atome de carbone du cycle
• A01N 25/30 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles caractérisés par les agents tensio-actifs
• A01P 13/00 - HerbicidesAlgicides

Abrégé

Disclosed is a method for preparing 3-chlorobicyclo[3.2.1]-3-octen-2-ol, which belongs to the field of pharmaceutical technology. The method for preparing 3-chlorobicyclo[3.2.1]-3-octen-2-ol can be achieved by any of the following reaction routes: Reaction route I: 3,4-dichlorobicyclo[3.2.1]-2-octene is esterified in the presence of a carboxylate, and hydrolyzed in a strong base to obtain 3-chlorobicyclo[3.2.1]-3-octen-2-ol; Reaction route II: in the presence of an inorganic salt of strong base and weak acid, 3,4-dichlorobicyclo[3.2.1]-2-octene is reacted in a solvent to obtain 3-chlorobicyclo[3.2.1]-3-octen-2-ol. The present application can result in decreased formation of polymers and impurities, more obvious layering, and improved purification efficiency.

Classes IPC  ?

• A01N 41/10 - SulfonesSulfoxydes
• A01N 43/40 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons
• A01P 13/00 - HerbicidesAlgicides
• C07C 23/30 - Système bicyclique mono-insaturé
• C07C 27/02 - Saponification d'esters d'acides organiques
• C07C 29/09 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par hydrolyse
• C07C 35/52 - Alcools contenant un système cyclique condensé
• C07C 67/11 - Préparation d'esters d'acides carboxyliques par réaction d'acides carboxyliques ou d'anhydrides symétriques avec des groupes ester ou avec une liaison carbone-halogène avec des groupes ester minéraux
• C07C 69/753 - Esters d'acides carboxyliques dont un groupe carboxyle est lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons d'acides polycycliques

Abrégé

The present application discloses a bicyclic ketone compound and a preparation method therefor, and a preparation method for bicyclo[3.2.1]-3-octane-2,4-dione, belonging to the technical field of medicaments. 3-chlorobicyclo[3.2.1]-3-octen-2-one reacts with an alcohol in the presence of a strong alkali and a catalyst under an anhydrous condition to generate 4-alkoxybicyclo[3.2.1]-3-octen-2-one, and then 4-alkoxybicyclo[3.2.1]-3-octen-2-one is hydrolyzed to obtain bicyclo[3.2.l]-3-octane-2,4-dione. In the present application, the intermediate compound III - 4-alkoxybicyclo[3.2.1]-3-octen-2-one is generated through the reaction of 3-chlorobicyclo[3.2.1]-3-octen-2-one with a strong alkali and an alcohol, and then a target product bicyclo[3.2.l]-3-octane-2,4-dione can be obtained in high yield through hydrolysis reaction.

Classes IPC  ?

• C07C 45/65 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par élimination d'atomes d'hydrogène ou de groupes fonctionnelsPréparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par hydrogénolyse de groupes fonctionnels
• C07C 49/633 - Composés non saturés comportant un groupe cétone faisant partie d'un cycle polycycliques le groupe cétone faisant partie d'un système cyclique condensé comportant deux cycles le système cyclique condensé contenant huit ou neuf atomes de carbone
• C07C 49/753 - Composés non saturés comportant un groupe cétone faisant partie d'un cycle contenant des groupes éther, des groupes , des groupes ou des groupes

Abrégé

The present invention provides an emulsifiable concentrate containing saflufenacil and clethodim, and a preparation method for the emulsifiable concentrate. The emulsifiable concentrate comprises the following components in percentage by mass: 5%-60% of clethodim, 1%-20% of saflufenacil, 10%-20% of an emulsifier, 5%-20% of a synergist, 10%-35% of a cosolvent, and a solvent supplemented to 100%. According to the present invention, the combination of the solvent and an auxiliary agent is adjusted, thereby solving the problem of separating out a saflufenacil crystal after diluting the emulsifiable concentrate with water and the problem of the stability of clethodim while ensuring the dissolution of saflufenacil; the combination basically does not affect the stability of clethodim, and the decomposition rate of clethodim is stably controlled within 8.5%, so that it can be ensured that no technical grade is separated out from a pesticide liquid at the use concentration of the emulsifiable concentrate, avoiding the risk of blocking a nozzle, and facilitating the exertion of the pesticide effect of saflufenacil. The combination improves the stability of effective components and achieves formula enhancement, and can ensure excellent pesticide effect performance. The improvement of the stability of clethodim also prolongs the shelf life of a formulation.

Classes IPC  ?

• A01N 43/54 - Diazines-1,3Diazines-1,3 hydrogénées
• A01N 35/10 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant deux liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. un radical aldéhyde au moins une des liaisons carbone-hétéro-atome étant une liaison carbone-azote comportant une double liaison carbone-azote
• A01N 25/22 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles contenant des ingrédients stabilisant les ingrédients actifs
• A01N 25/30 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles caractérisés par les agents tensio-actifs
• A01P 13/00 - HerbicidesAlgicides

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Abrégé

Disclosed in the present application are a bicyclone compound and a preparation method therefor, and a preparation method for bicyclo[3.2.1]-3-octane-2,4-dione, which belong to the technical field of pharmaceuticals. 3-chlorobicyclo[3.2.1]-3-octen-2-one reacts with an alcohol under anhydrous conditions and under the action of a catalyst and a strong alkali to generate 4-alkoxybicyclo[3.2.1]-3-octen-2-one, and same is then hydrolyzed to obtain bicyclo[3.2.1]-3-octane-2,4-dione. In the present application, 3-chlorobicyclo[3.2.1]-3-octen-2-one reacts with a strong alkali and an alcohol to generate intermediate compound III, i.e., 4-alkoxybicyclo[3.2.1]-3-octen-2-one, and the target product, i.e., bicyclo[3.2.1]-3-octane-2,4-dione can then be obtained in high yield by means of a hydrolysis reaction.

Classes IPC  ?

• C07C 49/753 - Composés non saturés comportant un groupe cétone faisant partie d'un cycle contenant des groupes éther, des groupes , des groupes ou des groupes
• C07C 45/64 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par introduction de groupes fonctionnels contenant de l'oxygène lié uniquement par liaison simple
• C07C 49/443 - Composés saturés comportant un groupe cétone faisant partie d'un cycle polycycliques un groupe cétone faisant partie d'un système cyclique condensé comportant deux cycles le système cyclique condensé contenant huit ou neuf atomes de carbone
• C07C 45/62 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par hydrogénation de liaisons doubles ou triples carbone-carbone

Abrégé

Disclosed in the present application is a preparation method for 3-chlorobicyclo[3.2.1]-3-octen-2-ol, which belongs to the technical field of pharmaceuticals. The preparation method for 3-chlorobicyclo[3.2.1]-3-octen-2-ol may be obtained by using any one of the following reaction routes: reaction route I: esterifying 3,4-dichlorobicyclo[3.2.1]-2-octylene under the action of a carboxylate, and hydrolyzing same in a strong alkali, so as to obtain 3-chlorobicyclo[3.2.1]-3-octen-2-ol; and reaction route II: allowing 3,4-dichlorobicyclo[3.2.1]-2-octylene to undergo a reaction in a solvent under the action of an inorganic strong alkali-weak acid salt, so as to obtain 3-chlorobicyclo[3.2.1]-3-octen-2-ol. The present application can reduce the generation of polymers and impurities, such that layering is more distinct, and the purification efficiency is improved.

Classes IPC  ?

• C07C 29/09 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par hydrolyse
• C07C 29/124 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par hydrolyse d'esters d'acides minéraux d'halogénures
• C07C 35/52 - Alcools contenant un système cyclique condensé
• C07C 67/11 - Préparation d'esters d'acides carboxyliques par réaction d'acides carboxyliques ou d'anhydrides symétriques avec des groupes ester ou avec une liaison carbone-halogène avec des groupes ester minéraux

Abrégé

A method for preparing a phenoxycarboxylate includes 1) allowing a salt of a phenolic compound and a halogenated carboxylate to subject to a condensation reaction in a polar solvent under the action of a catalyst; and 2) adding an acid-containing organic solvent to the condensation reaction liquid in step 1) to perform an acidification, and purifying the precipitated halogenated inorganic salt to obtain a phenoxycarboxylate. A catalyst is added in the condensation process, which can improve the reaction rate, achieve the reaction at room temperature and high material conversion rate, and avoid the problem in the prior art that the reaction needs to be performed at high temperature, about 120° C. After the condensation reaction is completed, the salt is removed by dry filtration (an anhydrous condition) by adding a methanol hydrogen chloride solution. There is no industrial wastewater, raw materials are easily recycled, and the reaction yield is high.

Classes IPC  ?

• C07C 67/08 - Préparation d'esters d'acides carboxyliques par réaction d'acides carboxyliques ou d'anhydrides symétriques avec le groupe hydroxyle ou O-métal de composés organiques

Abrégé

The present application discloses a preparation method for a phenoxy carboxylic acid ester, comprising: 1) a salt of a phenolic compound undergoing a condensation reaction with a halogenated carboxylic acid ester in a polar solvent under the action of a catalyst; and 2) adding an acid-containing organic solvent into the solution obtained by means of the condensation reaction in step 1) for acidification, precipitating a halogenated inorganic salt and purifying same to obtain a phenoxy carboxylic acid ester. According to the present application, adding a catalyst in a condensation process can increase the reaction rate and achieve a reaction at room temperature, so that the overall energy consumption is low, the material conversion rate is high, and the problem in the prior art of requiring a high-temperature reaction at about 120°C is avoided; after the condensation reaction is completed, a methanol hydrogen chloride solution is added to remove the salt by dry filtration (anhydrous conditions), so that no industrial waste water is produced, the recovery of raw materials is easy, the reaction yield is high, and the problems in the prior art of production of industrial waste water and high energy consumption due to a need to add water for extraction, crystallization and the like to obtain products are thus solved.

Classes IPC  ?

• C07C 67/31 - Préparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par introduction de groupes fonctionnels avec de l'oxygène lié uniquement par liaison simple
• C07C 69/708 - Éthers
• C07C 69/712 - Éthers le groupe hydroxyle de l'ester étant éthérifié par un composé hydroxylé dont le groupe hydroxyle est lié à un atome de carbone d'un cycle aromatique à six chaînons

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides, not being used for water treatment purposes or for swimming pools maintenance and care; Chemicals for use in pesticides, not being used for water treatment purposes or for swimming pools maintenance and care. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides; none of the above being used for water treatment purposes or for swimming pools maintenance and care.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Abrégé

Through an intermediate I (a compound having the structural formula as shown in the formula Ia and/or the formula Ib), or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a tautomer Ic of Ib, a bicyclopyrone intermediate II with a high yield can be prepared. Two compounds are docked first under the action of a base to produce an intermediate I, and then the intermediate I is subjected to intramolecular ring closure by an ammonium salt, which can increase the yield of the bicyclopyrone intermediate (II), reduce side reactions, and reduce problems that a reaction of raw materials is easily incomplete due to intramolecular ring closure directly through an ammonium salt. A one-pot method includes producing an intermediate I under the action of a base and then performing a ring-closure reaction to produce a bicyclopyrone intermediate (II) that reduces side reactions, and further increases the yield.

Classes IPC  ?

• C07C 67/42 - Préparation d'esters d'acides carboxyliques par oxydation des groupes précurseurs de la partie acide de l'ester d'alcools secondaires ou de cétones
• C07C 69/738 - Esters d'acides céto-carboxyliques
• C07D 309/32 - Composés hétérocycliques contenant des cycles à six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques

Abrégé

Provided are a compound, a method for preparing same, and use thereof in preparing a bicyclopyrone intermediate. The present invention can be used for preparing bicyclopyrone intermediate II from intermediate I (a compound represented by formula Ia and/or formula Ib) or a pharmaceutically acceptable salt thereof, a solvate thereof, and a tautomer Ic of Ib with a high yield. Two compounds are connected under the action of a base to give intermediate I, which is then subjected to an intramolecular ring-closing reaction using an ammonium salt. The present invention can significantly increase the yield of bicyclopyrone intermediate (II), reduce side reactions, and overcome the defect that the direct ring closure process with ammonium salts in the prior art can easily lead to incomplete reaction of raw materials, thus improving the yield.

Classes IPC  ?

• C07C 69/738 - Esters d'acides céto-carboxyliques
• C07C 67/343 - Préparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par isomérisationPréparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par modification de la taille du squelette carboné par augmentation du nombre d'atomes de carbone
• C07D 213/80 - AcidesEsters en position 3
• C07D 213/803 - Procédés de préparation

Abrégé

The present application discloses a compound, a preparation method therefor and an application of the compound in the preparation of a bicyclopyrone intermediate. Through an intermediate I (a compound having the structural formula as shown in the formula la and/or the formula lb), or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a tautomer Ic of lb, a bicyclopyrone intermediate II with a high yield can be prepared. In the present application, two compounds are docked first under the action of a base to produce an intermediate I, and then the intermediate I is subjected to intramolecular ring closure by an ammonium salt, which can remarkably increase the yield of the bicyclopyrone intermediate (II), reduce side reactions, and overcome the defects in the prior art that a reaction of raw materials is easily incomplete due to intramolecular ring closure directly through an ammonium salt.

Classes IPC  ?

• C07C 67/343 - Préparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par isomérisationPréparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par modification de la taille du squelette carboné par augmentation du nombre d'atomes de carbone
• C07C 69/734 - Éthers
• C07C 69/738 - Esters d'acides céto-carboxyliques
• C07D 213/803 - Procédés de préparation
• C07D 309/32 - Composés hétérocycliques contenant des cycles à six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Chemical preparations for use in photography; Chemical preparations and materials for film, photography and printing; Chemical preparations for use in the manufacture of printing materials; Chemical preparations for use in processing photosensitive material. Pharmaceuticals and natural remedies; Pharmaceuticals.

Produits et services

Chemical preparations for use in the manufacture of printing materials; Chemical preparations for use in processing photosensitive material; Chemical preparations for use in photography; Chemical preparations and materials for film, photography and printing. Pharmaceuticals; Pharmaceuticals and natural remedies.

Produits et services

Chemical preparations for use in the manufacture of printing materials; Chemical preparations for use in photography; Chemical preparations for use in processing photosensitive material; Chemical preparations and materials for film, photography and printing. Pharmaceuticals and natural remedies; Pharmaceuticals.

Produits et services

Chemical preparations for use in the manufacture of printing materials; Chemical preparations for use in processing photosensitive material; Chemical preparations for use in photography; Chemical preparations and materials for film, photography and printing. Pharmaceuticals; Pharmaceuticals and natural remedies.

Produits et services

Chemical preparations for use in the manufacture of printing materials; Chemical preparations for use in processing photosensitive material; Chemical preparations for use in photography; Chemical preparations and materials for film, photography and printing. Pharmaceuticals; Pharmaceuticals and natural remedies.

Produits et services

Chemical preparations for use in the manufacture of printing materials; Chemical preparations for use in processing photosensitive material; Chemical preparations for use in photography; Chemical preparations and materials for film, photography and printing. Pharmaceuticals; Pharmaceuticals and natural remedies.

Produits et services

Chemical preparations for use in the manufacture of printing materials; Chemical preparations for use in processing photosensitive material; Chemical preparations for use in photography; Chemical preparations and materials for film, photography and printing. Pharmaceuticals; Pharmaceuticals and natural remedies.

Produits et services

Chemical preparations for use in the manufacture of printing materials; Chemical preparations for use in photography; Chemical preparations for use in processing photosensitive material; Chemical preparations and materials for film, photography and printing. Pharmaceuticals; Pharmaceuticals and natural remedies.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Chemical additives for pesticides; Chemicals for use in pesticides. Pest control preparations and articles; Pesticides; Pesticides for horticultural use; Pesticides for agricultural use; Domestic pesticides.

Produits et services

Chemical preparations and materials for film, photography and printing; Chemical and organic compositions for use in the manufacture of food and beverages. Pharmaceuticals and natural remedies; Dietary supplements and dietetic preparations.

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.; Chemical additives for pesticides. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.; Chemical additives for pesticides. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.; Chemical additives for pesticides. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.; Chemical additives for pesticides. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.; Chemical additives for pesticides. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.; Chemical additives for pesticides. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Chemical additives for pesticides; Chemicals for use in pesticides; Surfactants for use in connection with agricultural pesticides; Chemicals for use as intermediates in the manufacture of pesticides; Agricultural chemicals; Chemicals for use in agriculture; Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry.. Pesticides; Nematode pesticide; Agricultural pesticides; Domestic pesticides; Pesticides for horticultural use; Pesticides for agricultural use..

Produits et services

Pest control preparations and articles; Herbicides; Fungicides; Insecticides.

Produits et services

Pest control preparations and articles; Herbicides; Fungicides; Insecticides.

Produits et services

Pest control preparations and articles; Herbicides; Fungicides; Insecticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Plant-growth regulators; Chemical substances, chemical materials and chemical preparations, and natural elements; Detergents for use in manufacture and industry; Adhesives for use in industry; Chemical preparations and materials for film, photography and printing; Salts for industrial purposes. Pest control preparations and articles; Herbicides; Fungicides; Insecticides.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Plant-growth regulators; Chemical substances, chemical materials and chemical preparations, and natural elements; Detergents for use in manufacture and industry; Adhesives for use in industry; Chemical preparations and materials for film, photography and printing; Salts for industrial purposes. Pest control preparations and articles; Herbicides; Fungicides; Insecticides; Disinfectants and antiseptics.

Produits et services

Growing media, fertilizers and chemicals for use in agriculture, horticulture and forestry; Plant-growth regulators. Pest control preparations and articles; Herbicides; Fungicides; Insecticides.

Abrégé

The present invention discloses a water-soluble granule formulation of 2,4-D salt, comprising components in the following weight percent: 5-80% 2,4-D salt (calculated as 2,4-D acid), and a water-soluble filler as the balance. The water-soluble granule formulation of 2,4-D salt has an outstanding control efficiency on annual or perennial Poaceae weeds and some broadleaf weeds in fields of soybean and other Fabaceae plants, for example, such weeds as amaranth, knotweed, lamb's-quarters night shade, siberian cocklebur, barnyard grass, foxtail grass, digitaria sanguinalis, broomcorn millet and the like. The formulation is environment-friendly, and has the advantages of being free of organic solvents and dusts and being easy to measure in comparison to conventional emulsifiable formulation, wettable powder formulation and suspension formulation. The present invention also discloses the preparation method of the formulation. The production process is simple, economical and safe. The whole production process, without the use of dangerous chemicals, is easy to control and operate and has a high safety factor.

Classes IPC  ?

• A01N 39/02 - Acides aryloxycarboxyliquesLeurs dérivés
• A01N 39/04 - Acides aryloxyacétiquesLeurs dérivés
• A01N 37/38 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant au moins un groupe carboxylique ou un thio-analogue, ou d'un de leurs dérivés, et un atome d'oxygène ou de soufre lié par une liaison simple, liés au même squelette carboné, cet atome d'oxygène ou de soufre ne faisant pas partie d'un groupe carboxylique ou d'un thio-analogue, ou d'une de leurs dérivés, p. ex. acides hydroxycarboxyliques contenant au moins un atome d'oxygène ou de soufre lié à un système cyclique aromatique

Abrégé

Disclosed is a 2,4-D saline-soluble granule, comprising components with the following weight percentage: 5-80% 2,4-D salt (calculated as 2,4-D acid), water-soluble packing residue. The 2,4-D saline-soluble granule is excellent at controlling annual or perennial gramineae weeds and certain broadleaved weeds in soybean fields and other Leguminosae fields, such as amaranth, knotweed, goosefoot, nightshade, Xanthium sibiricum, barnyard grass, green bristle grass, crabgrass, glutinous millet, etc. The preparation is an environmentally friendly dosage form, and has the following advantages compared with conventional emulsifiable concentrates, wettable powder and suspension concentrates: free of organic solvents and dust, and easy to measure. Also disclosed is a preparation method therefor. The method process is simple, economical, and safe; no dangerous chemicals are used during the whole production process, so the process is easy to control and operate, and the safety coefficient is high.

Classes IPC  ?

• A01N 25/12 - Poudres ou granulés
• A01N 39/04 - Acides aryloxyacétiquesLeurs dérivés
• A01P 13/00 - HerbicidesAlgicides

Abrégé

The present invention discloses a water-soluble granule formulation of 2,4-D salt, comprising components in the following weight percent: 5-80% 2,4-D salt (calculated as 2,4-D acid), and a water-soluble filler as the balance. The water-soluble granule formulation of 2,4-D salt has an outstanding control efficiency on annual or perennial Poaceae weeds and some broadleaf weeds in fields of soybean and other Fabaceae plants, for example, such weeds as amaranth, knotweed, lamb's-quarters, night shade, siberian cocklebur, barnyard grass, foxtail grass, digitaria sanguinalis, broomcorn millet and the like. The formulation is environment-friendly, and has the advantages of being free of organic solvents and dusts and being easy to measure in comparison to conventional emulsifiable formulation, wettable powder formulation and suspension formulation. The present invention also discloses the preparation method of the formulation. The production process is simple, economical and safe. The whole production process, without the use of dangerous chemicals, is casy to control and operate and has a high safety factor.

Classes IPC  ?

• A01N 25/14 - Poudres ou granulés mouillables
• A01N 39/04 - Acides aryloxyacétiquesLeurs dérivés
• A01P 13/00 - HerbicidesAlgicides