Abrégé

A multi-stage magnetic separation system, comprising a multi-stage separation channel unit (1), a magnet array unit (2), and a magnetic filtration unit (3), wherein the multi-stage separation channel unit (1) comprises a plurality of separation channel layers, the plurality of separation channel layers are sequentially stacked from top to bottom, and each separation channel layer is provided with a main separation channel and two outlet channels, so as to implement separation of particles of different sizes; the magnet array unit (2) comprises at least two magnet arrays, wherein one magnet arrays is a magnetic filtration magnet array and is used for providing the magnetic filtration unit with a magnetic field required by magnetic filtration, and the other magnet array is a separation magnet array and is used for providing the multi-stage separation channel unit with a magnetic field required by negative magnetophoretic separation; the magnetic filtration unit (3) is connected to the multi-stage separation channel unit (1).

Classes IPC  ?

• B03C 1/02 - Séparation magnétique agissant directement sur la substance à séparer

Abrégé

Disclosed is the use of a PHB2 gene or a PHB2 protein as a new immune checkpoint. Targeting PHB2 can inhibit mitochondrial fusion, thereby increasing mitochondrial fragmentation, elevating mitochondrial metabolic levels, and enhancing the anti-tumor function of cells in vivo and in vitro. Moreover, targeting PHB2 can reduce the expression of PD-1, and when used in combination with a CTLA-4 monoclonal antibody, can enhance anti-tumor effects. On this basis, further disclosed is the use of a drug having an inhibitory effect on a PHB2 gene or a PHB2 protein in the preparation of a PD-1 inhibitor, or the use of same in combination with a PD-1 monoclonal antibody in the preparation of a therapeutic product or a preventive product for treating or preventing tumors. Further disclosed is the use of a drug having an inhibitory effect on a PHB2 gene or a PHB2 protein in combination with a CTLA-4 monoclonal antibody in the preparation of a therapeutic product or a preventive product for treating or preventing tumors. Further disclosed is the use of a drug having an inhibitory effect on a PHB2 gene or a PHB2 protein alone, in combination with a PD-1 monoclonal antibody or in combination with a CTLA-4 monoclonal antibody in immunotherapy, especially tumor immunotherapy. It has been found in experiments that tumors in PHB2+/- tumor-bearing mice are significantly reduced compared with those in the control. It has been further found that targeting mitochondrial PHB2 can increase mitochondrial fragmentation by means of inhibiting mitochondrial fusion, so that the mitochondrial metabolism is enhanced; moreover, after PHB2 knockout, PD-1 expression is reduced, and when used in combination with a CTLA-4 monoclonal antibody, can enhance anti-tumor effects.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• G01N 33/533 - Production de composés immunochimiques marqués avec un marqueur fluorescent
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
• G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
• G01N 21/64 - FluorescencePhosphorescence
• A61P 35/00 - Agents anticancéreux

Abrégé

A phosphate detection reagent, a detection kit and a detection method. The detection reagent comprises a reagent A and a reagent B. The reagent A comprises a strong acid reagent, a molybdate and a weighting agent, at a mass ratio of the strong acid reagent to the molybdate to the weighting agent of (2-98) : (0.2-20.0) : (0-50.0). The reagent B comprises a strong acid reagent, a masking agent, a reducing agent, an accelerant and a weighting agent, at a mass ratio of the strong acid reagent to the masking agent to the reducing agent to the accelerant to the weighting agent of (2-98) : (1.0-30.0) : (0.5-50.0) : (0.1-50.0) : (0-50.0). The detection reagent has no special environmental requirements, no special three-waste pollution, low costs, simple and non-interfering detection steps with a higher accuracy, a short color development time and high portability.

Classes IPC  ?

• G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
• G01N 21/3577 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de liquides, p. ex. l'eau polluée

Abrégé

A silicate measurement reagent, a measurement kit, and a measurement method. The measurement reagent comprises a reagent 1, a reagent 2, and a reagent 3; the reagent 1 comprises a strongly acidic reagent and a weighting agent, and the mass ratio of the strongly acidic reagent to the weighting agent is (1-10):(2-10); the reagent 2 comprises molybdate and water, and the mass-to-volume ratio (g:mL) of molybdate to water is (1-50):(1-50); the reagent 3 comprises a masking agent, a reducing agent and water, and the mass-to-volume ratio (g:g:ml) of the masking agent to the reducing agent to water is (2-30):(10-50):(1-100). The measurement reagent has no special environmental requirements and no special three-waste pollution, and has low cost, the measurement steps are simple, no interference and more accurate measurement are achieved, the color development time is short, and the mobility is strong.

Classes IPC  ?

• G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
• G01N 21/01 - Dispositions ou appareils pour faciliter la recherche optique

Abrégé

The present invention relates to a magnetic resonance imaging technique for the carotid artery, and in particular to a wireless resonant ring, a magnetic resonance carotid artery array coil comprising the wireless resonant ring, and an imaging method. The wireless resonant ring uses a loop structure, can not only be used in conjunction with various commercial magnetic resonance carotid artery coils, but also combined with a carotid artery array coil to form a magnetic resonance carotid artery array coil having better imaging performance. Such a wireless resonant ring can enhance the distribution of B1- field near the wireless resonant ring, and hardly changes the distribution of B1+ field of the surrounding coil, thereby effectively improving the signal-to-noise ratio of imaging. In addition, compared with use of a carotid artery coil, addition of the wireless resonant ring is more conducive to imaging at a deeper subcutaneous position, thereby acquiring an image having higher resolution, higher signal-to-noise ratio and higher quality at the carotid artery position.

Classes IPC  ?

• G01R 33/34 - Détails de structure, p. ex. résonateurs
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• A61B 5/026 - Mesure du débit sanguin

Abrégé

The present application relates to an autism risk assessment method and device based on small sample data enhancement. The method comprises: collecting a multi-channel electroencephalogram signal of a subject; calculating the multi-channel electroencephalogram signal using a Pearson correlation coefficient to obtain the correlation between channels, generating a brain functional connectivity matrix, and constructing a brain time sequence connected graph according to time sequence information of the multi-channel electroencephalogram signal; and performing data enhancement processing on the brain time sequence connected graph using a generative adversarial network, inputting the brain time sequence connected graph after data enhancement processing into a trained deep convolutional network and long short-term memory network joint model for classification, and outputting an autism risk assessment result of the subject by a classifier. According to the embodiments of the present application, the differences between patients with autism and healthy people are taken into account from the perspective of brain functional connectivity, and the brain functional connectivity and the time information contained in an electroencephalogram signal are both taken into account, so that autism risk assessment can be more accurately performed on a subject.

Classes IPC  ?

• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• A61B 5/369 - Électroencéphalographie [EEG]

Abrégé

The present invention relates to a magnetic resonance contrast agent, a preparation method therefor, and use thereof. The magnetic resonance contrast agent comprises a lanthanide-binding protein mutant. The lanthanide-binding protein mutant is formed by mutating the 108th-position asparagine of the lanthanide-binding protein to aspartic acid. In the magnetic resonance contrast agent, the lanthanide-binding protein mutant is formed by mutating the 108th-position asparagine of the lanthanide-binding protein to aspartic acid, which is beneficial to improving the relaxation degree. Tests have proved that the effective relaxation degree of the magnetic resonance contrast agent (about 52 mM-1s-1) is 10 times that of Magnevist (about 5 mM-1s-1), so that the magnetic resonance contrast agent can be applied to magnetic resonance imaging detection.

Classes IPC  ?

• A61K 49/14 - Peptides, p. ex. protéines
• A61K 49/08 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par le support
• A61K 51/08 - Peptides, p. ex. protéines

Abrégé

Provided are a low-virulence, long-acting and high-capacity herpes simplex virus vector and the use thereof. Both copies of the neurovirulence factor V34.5 gene in the HSV-1 viral genome are completely knocked out, and an exogenous gene expression cassette is inserted at the original neurovirulence factor V34.5 gene locus. The exogenous gene expression cassette is selected from expression cassette I or expression cassette II, wherein the expression cassette I comprises a promoter, a fluorescent protein gene, a 2A peptide encoding gene, a Cre encoding gene, a WPRE transcription enhancement element and PA, which are connected in sequence, and the expression cassette II comprises a promoter, a SpCas9 or other nuclease encoding genes, a 2A peptide encoding gene, a fluorescent protein gene, a promoter, a sgRNA for targeted editing of the target gene and PA, which are connected in sequence. The vector and the use thereof expand the application scope of attenuated ItHSV vectors in neural circuit labeling and gene delivery transduction, providing a new vector for neural circuit tracing labeling and long-term gene delivery and expression of exogenous genes.

Classes IPC  ?

• C12N 7/01 - Virus, p. ex. bactériophages, modifiés par l'introduction de matériel génétique étranger
• C12N 15/38 - Herpétoviridae, p. ex. virus de l'herpès simplex, herpesvirus varicellae, virus Epstein-Barr, cytomégalovirus, virus de la pseudorage
• C12N 15/869 - Vecteurs herpèsviraux
• C12N 15/65 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression utilisant des marqueurs
• C12N 15/55 - Hydrolases (3)
• C12N 15/61 - Isomérases (5)

Abrégé

The use of a reagent, which detects changes in the concentration or number of immune cells and immune factors in the peripheral circulatory system and cerebrospinal fluid, in the preparation of a diagnostic tool or a therapeutic tool for diagnosing or monitoring Alzheimer's disease. A method for diagnosing or monitoring Alzheimer's disease, in which a reagent for detecting immune cells and immune factors in the peripheral circulatory system and cerebrospinal fluid is used to detect changes in the concentration or number of the immune cells and immune factors in the peripheral circulatory system and cerebrospinal fluid. A method for treating Alzheimer's disease, in which immune cells and immune factors in the peripheral circulatory system and cerebrospinal fluid are taken as targets for administration so as to reduce or decrease the concentration or number of the immune cells and immune factors.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet

Abrégé

A drug for preventing or treating steroid-induced osteonecrosis of the femoral head, comprising an active ingredient cycloastragenol. The drug can remarkably improve intraosseous blood supply in the steroid-induced osteonecrosis of the femoral head, reduce formation of necrotic areas and empty lacunae, decrease excessive bone resorption and reduce CTSK protein expression, and provide a potential prevention and treatment scheme for treatment of steroid-induced osteonecrosis of the femoral head.

Classes IPC  ?

• A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
• A61P 19/08 - Médicaments pour le traitement des troubles du squelette des maladies osseuses, p. ex. rachitisme, maladie de Paget
• A61P 19/10 - Médicaments pour le traitement des troubles du squelette des maladies osseuses, p. ex. rachitisme, maladie de Paget de l'ostéoporose

Abrégé

Disclosed in the present invention is a method for extracting circulating tumor cells, comprising the following steps: labeling circulating tumor cells in a sample to be extracted by means of metabolic glycoengineering, to obtain a sample to be extracted containing the labeled circulating tumor cells; using a biotin-streptavidin magnetic bead system to capture the labeled circulating tumor cells from the sample to be extracted; and using a reducing reagent to reduce the captured labeled circulating tumor cells, to obtain circulating tumor cells.

Classes IPC  ?

• C12N 5/09 - Cellules tumorales
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

The present invention relates to the technical field of biology and new drugs, and provides a method for in-vitro expansion of a primary cytotoxic T cell subset. The method comprises the following steps: coculturing CD8+T cells and adult mouse microglia cells in a culture medium containing fetal bovine serum, double antibodies and DMEM/F12 of Aβ; and using CD3/CD28 immunomagnetic beads to perform magnetic cell separation. The embodiments of the present invention indicate that the primary CD8+T cells separated from the peripheral blood and spleen of an AD mouse and intracerebral microglia cells are cocultured in vitro, so as to simulate a glial cell-mediated antigen presentation system (APC), so that the in-vitro expansion speed of the cytotoxic T cells can be rapidly increased and reach 1.5 times a conventional T cell expansion speed. Moreover, in this process, an APC does not need to be manually synthesized, thereby greatly saving the cost of in-vitro expansion of cytotoxic T cells.

Classes IPC  ?

• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet

Abrégé

Disclosed in the present inventio are a method for preparing a hard carbon negative electrode material, a use thereof, a negative electrode sheet, and a battery, and provided is a method for rapid and large-scale preparation of a hard carbon material by means of a dielectric barrier discharge (DBD) plasma-assisted sintering technology and transfer. The preparation method has a high temperature rise rate (100-1000°C/min), a short sintering time (20 seconds to 30 minutes), and a low energy consumption, thereby improving the production efficiency of the hard carbon negative electrode material, reducing the energy consumption and cost, and realizing controllable adjustment of the microstructure of the material. Moreover, the method allows for preparation under atmospheric pressure, and by means of a roll-to-roll transfer process, implements rapid and large-scale preparation of the hard carbon negative electrode material, thereby further improving the efficiency of the preparation procedure. In addition, carbon source materials are widely available, the microstructure and doping characteristics of the hard carbon negative electrode material can also be effectively regulated and controlled, and rapid and large-scale preparation of the hard carbon negative electrode material is finally realized. When used as a negative electrode material for a sodium-ion battery, the above hard carbon material can exhibit excellent sodium storage performance.

Classes IPC  ?

• C01B 32/05 - Préparation ou purification du carbone non couvertes par les groupes , , ,

Abrégé

An array-type multi-channel sensing electrode and an electrochemical detection method. The array-type multi-channel sensing electrode comprises N columns of detection electrode groups and N/2 or (N+1)/2 reference electrodes, wherein each detection electrode group outputs a detection signal by means of a separate detection channel, each detection electrode group includes M detection electrodes, and one reference electrode is arranged between every two columns of detection electrode groups; and each detection electrode comprises one counter electrode and one working electrode, and the counter electrode is arranged around the working electrode. On the basis of different detection principles, different detection channels and different detection modes can be set to perform simultaneous detection on different substances to be subjected to detection, such that simultaneous and accurate detection can be realized even when there is a large variety of substances to be subjected to detection.

Classes IPC  ?

• G01N 27/00 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques

Abrégé

A battery negative electrode, a preparation method, and a battery. Active substance, an active substance dissolution inhibitor, a composite hydrogen evolution inhibitor, a rare earth additive, a carbon-based conductive toughening agent and a polytetrafluoroethylene (PTFE) binder are used as raw materials. First, the active substance dissolution inhibitor, the composite hydrogen evolution inhibitor and the rare earth additive are uniformly mixed in a suspension, to ensure the dispersion uniformity; zinc powder and a certain amount of zinc oxide are then added to convert the suspension into viscous slurry; and next, the carbon-based conductive toughening agent is added, and the carbon-based conductive toughening agent is uniformly dispersed by utilizing the frictional shear force between the slurry and powder, to form a three-dimensional conductive network. A large number of dissolution/deposition reaction active sites can be provided for the zinc-based active substance, and the corrosion resistance of the zinc negative electrode is enhanced, improving the capacity and stability of the zinc negative electrode. In addition, in a semi-dry process, PTFE can be fiberized under the action of mechanical force, and the resulting mixture is in the form of a colloidal mass, resembling dough; the processability is high, the electrode sheet loading capacity is high, and the electrode structure is stable; the electrode sheet has excellent film-forming properties and controllable thickness; and the capacity and stability of the zinc negative electrode are improved.

Classes IPC  ?

• H01M 4/30 - Pressage
• H01M 10/24 - Accumulateurs alcalins

Abrégé

Disclosed in the present invention are a recombinant yeast strain for synthesizing an aromatic compound, and a construction method for and use of the recombinant yeast strain. According to the recombinant yeast strain for synthesizing the aromatic compound, Saccharomyces cerevisiae QL35 is used as a chassis, heterologously introduced phosphoketolase replaces endogenous non-oxidized phosphopentose pathway of Saccharomyces cerevisiae cells, a necessary substrate, namely, erythrose 4-phosphate, of the aromatic compound is synthesized, and acetyl phosphate is generated at the same time. Pyruvate kinase is further knocked out, the decomposition of phosphoenolpyruvic acid into pyruvic acid is blocked, and at the moment, the recombinant strain can only be converted into acetyl coenzyme A by means of acetyl phosphate to drive the growth of cells. Finally, a metabolic pathway is transformed into coupling product production and cell growth, and a recombinant yeast strain with high aromatic compound yield is obtained by means of adaptive evolution. The strain reduces the production cost by using glucose and an inorganic salt culture medium, and the growth-coupled recombinant yeast strain has the advantage of maintaining stable genetic character in fermentation process.

Classes IPC  ?

• C12N 1/19 - LevuresLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12N 15/55 - Hydrolases (3)
• C12N 15/53 - Oxydoréductases (1)
• C12P 7/42 - Acides hydroxycarboxyliques
• C12R 1/865 - Saccharomyces cerevisiae

Abrégé

Carbon monoxide core-shell nanoparticles capable of intravenous administration, a preparation method therefor, and use thereof, belonging to the technical field of nanomedicine. The preparation method for the carbon monoxide core-shell nanoparticles comprises: 1. preparing a polymer carrier PLGA(CO); 2. purifying the PLGA(CO); 3. weighing the PLGA(CO) and a functional material, dissolving them in THF, adding deionized water after ultrasonication, blowing off THF by using nitrogen, carrying out co-precipitation, centrifuging, washing, and carrying out co-precipitation to obtain a nanoparticle functional material @PLGA(CO); and 4. weighing DSPE-PEG, and reacting with the functional material @PLGA(CO) to obtain a functional material @PLGA(CO)@PEG. After a tail intravenous injection, the core-shell structure nanoparticles target a cancer site by means of intravenous injection under the monitoring of NIR-II fluorescence, and CO-enhanced mild temperature photothermal therapy is achieved to eliminate tumors.

Classes IPC  ?

• A61K 9/51 - Nanocapsules
• A61K 33/00 - Préparations médicinales contenant des ingrédients actifs inorganiques
• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
• A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
• A61P 35/00 - Agents anticancéreux

Abrégé

luxtetluxtettet; and transforming the first plasmid into an Escherichia coli MG1655 strain to construct engineered Escherichia coli containing a self-induction system.

Classes IPC  ?

• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C12R 1/19 - Escherichia coli

Abrégé

Provided are a bone repair material, a preparation method therefor, and use thereof. The bone repair material is prepared by printing with a material slurry by means of a photocuring 3D printing method and then sintering. The material slurry comprises the following components: 55-65% by mass of bioactive glass, 30-40% by mass of photosensitive resin, 1-5% by mass of a dispersing agent, and 0.1-1% by mass of a photoinitiator. The bone repair material has excellent biocompatibility and relatively high porosity, with the hemolysis rate lower than 5% and the cytotoxicity less than 30%. In addition, the bone repair material has relatively good morphology and relatively superior mechanical properties, and thus can be used as a bone repair scaffold material.

Classes IPC  ?

• A61L 27/10 - Céramiques ou verres
• A61L 27/16 - Matériaux macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• A61L 27/56 - Matériaux poreux ou cellulaires
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 70/10 - Composites de différents types de matériaux, p. ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
• B33Y 80/00 - Produits obtenus par fabrication additive

Abrégé

Embodiments of the present application relate to the technical field of computers. Disclosed are a conversational Text-to-SQL pre-training method and apparatus based on fine-grained link information. The method comprises: obtaining text statements of a conversation and a database schema, wherein the text statements comprise the current statement and a historical statement of the conversation; obtaining a statement link relationship between the statements in the conversation on the basis of the text statements of the conversation and the database schema, and obtaining a first loss function; obtaining a schema link relationship between the conversation and a database on the basis of the current statement of the conversation and the database schema, and obtaining a second loss function; and pre-training a neural network model on the basis of the first loss function and the second loss function to obtain a pre-trained Text-to-SQL model. The present application solves the problems in the prior art of low accuracy, cross-domain failure, and conversation context forgetting.

Classes IPC  ?

• G06F 16/2452 - Traduction des requêtes

Abrégé

The present invention particularly relates to the technical field of data storage, and provides a data encryption method based on DNA encoding, a data decryption method based on DNA encoding, an intelligent terminal, and a medium. A solution comprises: encrypting acquired data to be encoded to obtain encrypted data to be encoded; on the basis of a pre-constructed DNA encoding table, performing DNA encoding on each byte of said encrypted data to obtain an initial base sequence, the DNA encoding table being constructed from four-base units and five-base units; and using a preset DNA sequence structure optimization rule to perform chaotic mapping adjustment and rearrangement on the initial base sequence to obtain an encrypted DNA sequence. According to the solution, the GC content in the encrypted DNA sequence can be kept in a balanced state, and the information density of the encrypted data is increased, such that the encryption effect is effectively improved, thereby reducing a storage space occupied by data to be encoded, improving the security and attack resistance of the data to be encoded, and thus guaranteeing the stability of the encrypted DNA sequence.

Classes IPC  ?

• H04L 9/40 - Protocoles réseaux de sécurité
• G16B 50/30 - Entreposage de donnéesArchitectures informatiques
• G06F 16/172 - Mise en cache, pré-extraction ou accumulation de fichiers

Abrégé

The present invention relates to the technical field of thermoelectricity. Disclosed are a bismuth-telluride-based thermoelectric element, a bismuth-telluride-based thermoelectric device and a preparation method therefor. The bismuth-telluride-based thermoelectric element comprises a bismuth-telluride-based thermoelectric material layer and a barrier layer, which is located on one surface of the bismuth-telluride-based thermoelectric material layer, wherein the barrier layer comprises a nickel-iron alloy. When an Sn-based solder is used to weld an electrode on the bismuth-telluride-based thermoelectric element provided in the present invention, the barrier layer comprising a nickel-iron alloy can effectively inhibit the diffusion of Te in the bismuth-telluride-based thermoelectric material into a welding layer to form an Sn-Te intermetallic compound with Sn in the welding layer, and a relatively thin interfacial reaction layer having an interface contact resistivity of less than 1 μΩ•cm2 is provided between the barrier layer comprising a nickel-iron alloy and the bismuth-telluride-based thermoelectric material layer. The barrier layer comprising a nickel-iron alloy used in the present invention has a great application value in the packaging of thermoelectric devices.

Classes IPC  ?

• H10N 10/00 - Dispositifs thermoélectriques comportant une jonction de matériaux différents, c.-à-d. dispositifs présentant l'effet Seebeck ou l'effet Peltier

Abrégé

22 reduction reaction activity and the multicarbon product selectivity. Furthermore, by incorporating a widely applicable metal layer growth strategy, the activity and selectivity of single products, especially multicarbon products, can be regulated through the selective optimization of different types of single metals or multi-component alloys.

Classes IPC  ?

• C25B 11/032 - Électrodes à diffusion de gaz
• C25B 3/26 - Réduction du dioxyde de carbone
• C08F 230/08 - Copolymères de composés contenant un ou plusieurs radicaux aliphatiques non saturés, chaque radical ne contenant qu'une seule liaison double carbone-carbone et contenant du phosphore, du sélénium, du tellure ou un métal contenant un métal contenant du silicium
• C08F 220/34 - Esters contenant de l'azote

Abrégé

The present invention relates to an MRI brain image data processing method, comprising: preprocessing MRI brain image data to obtain a gray matter image and a white matter image that are registered into a standard space; using Box-Cox transformation to respectively standardize the obtained gray matter image and white matter image; and performing weight assignment on the standardized gray matter image and white matter image, and allocating variable computing resources. The present invention also relates to an MRI brain image data processing system. The present invention can implement balanced learning of the gray and white matter lesion features of a disease while preserving whole-brain feature information, and thus has strong robustness and high accuracy.

Classes IPC  ?

• G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo

Abrégé

The present application relates to the technical field of computers, and provides an idiomatic sentiment lexicon expansion method and apparatus based on dual chain-of-thoughts, an electronic device, and a storage medium. The method comprises: obtaining a corresponding target idiom; obtaining a target example sentence set corresponding to the target idiom; determining a corresponding first sentiment label on the basis of each target example sentence among the target example sentence set; obtaining target origin information corresponding to the target idiom; retrieving a corresponding origin description example sentence set on the basis of the target origin information; determining a corresponding second sentiment label on the basis of each origin description example sentence among the origin description example sentence set; on the basis of the first sentiment label and the second sentiment label, determining a target idiom label corresponding to the target idiom; and updating the target idiom label into a sentiment lexicon. The present application solves the problem in the related art that sentiments of existing idioms cannot be timely and accurately enhanced.

Classes IPC  ?

• G06F 40/242 - Dictionnaires

Abrégé

The present invention provides a novel waist and back pain measurement device for a small animal, and a method. The measurement device comprises: a support frame; a rotating member rotatably arranged on the support frame, wherein a rotating surface formed by rotating the rotating member is perpendicular to the horizontal plane; and a supporting structure fixedly arranged on the rotating member and used for supporting a small animal, wherein the small animal can continuously run on the supporting structure, and the small animal drives the rotating member by means of the supporting structure during running, so that the rotating member periodically rotates in one direction. The device further comprises a measurement assembly used for measuring the movement distance, speed and time of the small animal. By means of the provision of the rotary supporting structure, the small animal can run spontaneously without manual interference, and the measurement assembly can measure the movement distance, speed and time of the small animal; and experimenters can compare the pain threshold levels of the waist and back pain mice on the basis of the measured data.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

An enrichment device for sample concentration, comprising a support (100), a concentration container (200) and a magnetic component (300), wherein the support (100) is provided with an accommodating cavity (110); the concentration container (200) is mounted in the accommodating cavity (110), and the concentration container (200) is used for containing an eluent; and the magnetic component (300) is arranged on the support (100) and located below the accommodating cavity (110). When a magnetic bar assembly having magnetic beads is inserted into the concentration container (200), the magnetic beads can be attracted by the magnetic component (300) to separate from the magnetic bar assembly and then fall into the eluent.

Classes IPC  ?

• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

Abrégé

A process scheduling method and apparatus, a device and a storage medium, relating to the technical field of production scheduling. The method comprises: receiving a process scheduling request (S201); in response to the process scheduling request, determining an instruction being executed, an instruction to be executed, and scheduling resource information (S202); establishing an objective function and a constraint condition on the basis of the instruction being executed, the instruction to be executed, the scheduling resource information and corresponding actual scheduling information (S203); optimizing the objective function under the constraint condition by means of a swarm intelligence optimization algorithm to obtain an optimal solution of the objective function (S204); and using the optimal solution to determine an instruction execution policy, so as to perform process scheduling (S205). According to the process scheduling method, scheduling resources such as instruments and devices can be fully utilized, and the continuously growing demand for production scheduling is met.

Classes IPC  ?

• G05B 19/418 - Commande totale d'usine, c.-à-d. commande centralisée de plusieurs machines, p. ex. commande numérique directe ou distribuée [DNC], systèmes d'ateliers flexibles [FMS], systèmes de fabrication intégrés [IMS], productique [CIM]
• G06F 9/48 - Lancement de programmes Commutation de programmes, p. ex. par interruption

Abrégé

Disclosed in the present application is a hanging type weighing device for marmosets. The present application relates to the technical field of interventional medical examinations. The present application does not require manually capturing and weighing marmosets, does not cause harms to marmoset bodies, can efficiently obtain a large amount of continuous data, and can monitor marmosets in a pregnancy phase with rapid weight changes, and thus deduce a period of pregnancy thereof. The device comprises a box body and a controller; the box body is hung on an observation window of a marmoset cage; a side wall of the box body is provided with an entrance for the marmosets to enter and exit; a weighing chamber is defined in the box body; the bottom of the weighing chamber is provided with a weighing sensor; the controller is located outside the box body; the controller is in communication connection with the weighing sensor; and after weighing utilizing the weighing sensor, the controller can read and analyze the weighing result.

Classes IPC  ?

• G01G 17/08 - Appareils ou méthodes pour peser un produit ayant une forme ou des propriétés particulières pour peser du bétail
• G01G 17/00 - Appareils ou méthodes pour peser un produit ayant une forme ou des propriétés particulières
• G01G 23/00 - Dispositifs accessoires pour appareils de pesée
• G01G 23/18 - Dispositifs indicateurs, p. ex. pour indication à distanceDispositifs enregistreursÉchelles, p. ex. graduées

Abrégé

A preparation method for a uterus-targeting engineered extracellular vesicle and the use of same, belonging to the technical field of biomedicines. The uterus-targeting engineered extracellular vesicle of the present invention is obtained by collecting a supernatant of cells that stably overexpress Lamp2b protein and separating same, the amino acid sequence of the Lamp2b being selected from one amino acid sequence of or a combination of more than one amino acid sequence of SEQ ID NO. 1-7, or a derivative sequence taking one amino acid sequence of SEQ ID NO. 1-7 as a backbone, or a derivative sequence taking a combination of more than one amino acid sequence of SEQ ID NO. 1-7 as a backbone, or a homologous sequence of one amino acid sequence of or a combination of more than one amino acid sequence of SEQ ID NO. 1-7 in different species. The extracellular vesicle of the present invention has the characteristic of targeting the uterus and can deliver clinical diagnosis and treatment related molecules to the uterus, and therefore is suitable for use in physiological function research/research and diagnosis and treatment for intervention of uterus-derived diseases for humans and animals.

Classes IPC  ?

• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique

Abrégé

A preparation method for an engineered extracellular vesicle targeting oncofetal chondroitin sulfate-positive cells, and the use of same, belonging to the technical field of biomedicines. The present invention provides an engineered extracellular vesicle targeting oncofetal chondroitin sulfate-positive cells, which is obtained by collecting a supernatant of cells that stably overexpress a protein containing ofCSbps and separating same, the sequence of the ofCSbps being one of or a combined polypeptide sequence of more than one of SEQ ID NO. 1-7, or a derived sequence taking one polypeptide sequence of SEQ ID NO. 1-7 as a backbone, or a derived sequence taking a combined polypeptide sequence of more than one of SEQ ID NO. 1-7 as a backbone. The engineered extracellular vesicle of the present invention has the characteristic of targeting ofCS-positive cells. Since extracellular vesicles have nanoscale liposome encapsulation structures, the present invention is suitable for basic research and clinical diagnosis and treatment application on various diseases, such as placenta-derived physiological/pathological and tumor/cancer diseases, in humans and animals.

Classes IPC  ?

• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• C12N 15/86 - Vecteurs viraux
• A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
• A61P 35/00 - Agents anticancéreux

Abrégé

Disclosed in the present application is a medical image focus localization method, which comprises: acquiring an original sample of a medical image, and inputting the original sample into a trained generative adversarial network, the generative adversarial network comprising a coder and a decoder; by means of the coder, extracting an individual association feature and a class association feature of the original sample, and coding the individual association feature and the class association feature to acquire an individual style feature coding vector and a class association feature coding vector; performing topology analysis on the class association feature coding vector to obtain a class style feature coding vector; inputting the individual style feature coding vector and the class style feature coding vector into the decoder, the decoder being used for generating a synthetic sample that has been subjected to class migration; and comparing the original sample with the synthetic sample to obtain a focus image sample having a focus location. The present application uses the deep learning of the generative adversarial network to acquire a large amount of medical data and, by means of topology analysis, effectively localizes foci.

Classes IPC  ?

• G06T 7/00 - Analyse d'image

Abrégé

The present invention relates to an expression unit of a PET hydrolase, a recombinant vector, recombinant Pseudomonas putida, and a construction method therefor and the use thereof. The expression unit of PET hydrolase comprises a constitutive expression promoter of Pseudomonas putida, an anchor protein gene, a PET hydrolase gene and a protein expression terminator of Pseudomonas putida, all of which are linked. In the above expression unit of PET hydrolase, the anchor protein gene is linked to the PET hydrolase gene, and the promoter and terminator of Pseudomonas putida are linked thereto, which enables the display of PET hydrolase on the surface of Pseudomonas putida. The resulting PET hydrolase has a relatively high catalytic activity and can be used for the enzymatic degradation of PET plastics. Experiments verify that recombinant Pseudomonas putida P. putida/pMCS-PETase-AT containing the above expression unit exhibits the catalytic enzyme activity of PET hydrolase on BHET, with a higher catalytic activity compared to a wild-type strain.

Classes IPC  ?

• C12N 15/78 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour Pseudomonas
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12N 9/18 - Hydrolases agissant sur les esters d'acides carboxyliques
• B09B 101/75 - Déchets plastiques
• C12R 1/40 - Pseudomonas putida

Abrégé

Provided are a plastic-degrading recombinant bacterium, and a construction method and use therefor. The genome of the plastic-degrading recombinant bacterium is integrated with PETase gene, MHETase gene, tphA1 gene, tphA2 gene, tphA3 gene, tphB gene and tpaK gene, can degrade PET and PBAT plastic in natural environments, and the degradation efficiency is high.

Classes IPC  ?

• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger

Abrégé

The present invention relates to a use of a recombinant microorganism, and a plant culturing method. The recombinant microorganism is applied to the preparation for indoleacetic acid. The genome of the microorganism is integrated with a PETase gene, an MHETase gene, a tphA1 gene, a tphA2 gene, a tphA3 gene, a tphB gene, and a tpaK gene. The recombinant microorganism with the PETase gene, the MHETase gene, the tphA1 gene, the tphA2 gene, the A3 gene, the tphB gene, and the tpaK gene integrated in the genome can degrade PET and PBAT plastics under natural conditions, and has high degradation efficiency. The recombinant microorganism uses plastics such as PET plastic and PBAT plastic as carbon sources to synthesize a plant growth hormone indoleacetic acid, thereby achieving preparation for indoleacetic acid, and the recombinant microorganism transforms degradation products into indoleacetic acid to promote plant growth while accelerating the degradation of waste plastics in the environment, thereby reducing secondary pollution.

Classes IPC  ?

• C12P 17/10 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'azote comme unique hétéro-atome du cycle
• A01H 1/00 - Procédés de modification des génotypes

Abrégé

An organic positive electrode, a double-ion battery and a preparation method therefor and use thereof. The double-ion battery comprises a positive electrode, the positive electrode comprises a positive electrode material layer, and the positive electrode material layer comprises a polymer generated by performing in-situ electropolymerization on an active material; and the active material is selected from carbazole and/or a carbazole derivative. The active material in the positive electrode undergoes in-situ electropolymerization during charging, and is converted into the polymer by means of small molecules, the solubility in an electrolyte is reduced, the energy storage stability of the positive electrode is improved, and the double-ion battery comprising the positive electrode has excellent specific capacity and cycle stability. When working, the positive electrode and a negative electrode of the double-ion battery respectively perform anion storage and cation storage, and the battery has high working voltage and excellent specific capacity and cycle stability due to intercalation/deintercalation of large-size anions (bis(fluorosulfonyl)imide ions/bis(trifluoromethanesulfonyl)imide ions).

Classes IPC  ?

• H01M 4/137 - Électrodes à base de polymères électro-actifs
• H01M 4/1399 - Procédés de fabrication d’électrodes à base de polymères électro-actifs
• H01M 4/60 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés organiques
• H01M 10/052 - Accumulateurs au lithium
• H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p. ex. au magnésium ou à l'aluminium
• H01M 10/058 - Structure ou fabrication

Abrégé

The present application relates to the technical field of interventional surgical medical devices, and discloses a magnetic navigation system for cerebrovascular intervention, which not only can control a catheter guidewire to deflect in an expected direction when a blood vessel bifurcates or exhibits a sharp bend, so as to achieve the function of turning at a large angle or entering a target blood vessel, but also can generate a rotating magnetic field to drive the catheter guidewire to rotate when punch biopsy or thrombus removal is required. The system comprises a linear guide rail, and a catheter guidewire tail end turning navigation device and a catheter guidewire tail end rotation driving device which are slidably connected to the linear guide rail; the catheter guidewire tail end turning navigation device comprises an annular guide rail and a first magnetic member mounting sliding block slidably connected to the annular guide rail; the first magnetic member mounting sliding block can slide in the circumferential direction of the annular guide rail; a first magnetic member is provided on the first magnetic member mounting sliding block; and the catheter guidewire tail end rotation driving device can generate a rotating magnetic field and drive the tail end of a catheter guidewire to rotate.

Classes IPC  ?

• A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
• A61B 34/30 - Robots chirurgicaux

Abrégé

A tomography imaging system integrating optical microscopic imaging and large sample biological tissue slicing. By means of integration and synchronization of physical slicing and the imaging system, massive three-dimensional image information of an isolated organ or biological tissue can be acquired in a short time. Moreover, the system uses a remote focusing technology to increase an axial scanning speed, greatly shortening the imaging time, and increasing the image data acquisition throughput. In addition, the system is equipped with a dual-excitation optical path for dual-color imaging, so that two different tissue component information can be acquired at the same time.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/00 - Microscopes
• G02B 21/18 - Aménagements avec plus d'un parcours de lumière, p. ex. pour comparer deux échantillons

Abrégé

The present application relates to the field of drug testing technology, and specifically, to an analytical method for comparing the anti-anxiety effects of different drugs. To some extent, the method can solve the problem in existing studies where it is challenging to directly evaluate the anti-anxiety effects of various drugs and acquire a specific ranking, thereby providing a reference for people in need. The method comprises: acquiring experimental mice and dividing them into a plurality of treatment groups and a control group; administering different drugs to mice of each treatment group by oral gavage; subjecting the mice to stress stimuli to construct a stress model; conducting a number of experimental tests on the mice in each group; and calculating a z-score in each test, and ranking the anti-anxiety effects of the different treatment groups according to the z-scores of each group.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61K 49/00 - Préparations pour examen in vivo
• A61P 25/22 - Anxiolytiques

Abrégé

Provided are a Chlorella microalga and the use thereof in wastewater treatment, the microalga being Chlorella sp., and the accession number thereof being CCTCCM 20231952. The wastewater includes municipal wastewater, food processing wastewater, printing and dyeing industrial wastewater and animal husbandry breeding wastewater.

Classes IPC  ?

• C12N 1/12 - Algues unicellulairesLeurs milieux de culture
• C02F 3/32 - Traitement biologique de l'eau, des eaux résiduaires ou des eaux d'égout caractérisé par les animaux ou végétaux utilisés, p. ex. les algues
• C12R 1/89 - Algues

Abrégé

A cell autophagy-based membrane protein-targeted degradation agent. The degradation agent has a first structure binding to a membrane protein, and also has a second structure that induces a cell autophagy characteristic, wherein the first structure is connected to the second structure. The cell autophagy-based membrane protein-targeted degradation agent first uses a cell autophagy mechanism to carry out membrane protein degradation, and since this autophagy is an intrinsic mechanism for various cells, universal induction can be carried out in various cells without relying on a lysosome transporter protein, an E3 ligase and other factors on a cell membrane, and thus, the present invention has the characteristics of broad spectrum and higher universality. The design route of the first structure being directly connected to the second structure is simply and easily implemented.

Classes IPC  ?

• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
• A61K 31/787 - Polymères contenant de l'azote contenant des hétérocycles ayant l'azote comme hétéro-atome d'un cycle

Abrégé

A self-encapsulated thermoelectric power generation module, comprising a first copper-clad substrate, the first copper-clad substrate being connected to a stamped housing to form a sealed space, and the sealed space internally comprising a thermally conductive buffer layer, a second copper-clad substrate, a diffusion barrier layer and an N/P thermocouple pair, which are sequentially stacked, wherein the N/P thermocouple pair is connected to the first copper-clad substrate; the first copper-clad substrate is a double-layer vertically interconnected ceramic copper-clad substrate; and the double-layer vertically interconnected ceramic copper-clad substrate comprises a first-layer copper-clad substrate and a second-layer copper-clad substrate, which are mutually connected, the first-layer copper-clad substrate comprising a first surface and a first copper-clad surface, first electrodes being provided on the first surface, and being connected to the N/P thermocouple pair, a gap being provided between the first electrodes, a second electrode being provided on the first copper-clad surface, a first isolation band being provided outside the second electrode, and the first-layer copper-clad substrate being in electrode connection with the second-layer copper-clad substrate by means of a via. The problem of a device being oxidized in air is alleviated.

Classes IPC  ?

• H10N 10/17 - Dispositifs thermoélectriques comportant une jonction de matériaux différents, c.-à-d. dispositifs présentant l'effet Seebeck ou l'effet Peltier fonctionnant exclusivement par les effets Peltier ou Seebeck caractérisés par la structure ou la configuration de la cellule ou du thermocouple constituant le dispositif

Abrégé

Provided is an autophagy-based degrader targeting a membrane protein, which degrader comprises a membrane protein-targeting antibody, a nano secondary antibody and a cationic polymer, wherein the nano secondary antibody is linked to the cationic polymer, and the nano secondary antibody binds to the membrane protein-targeting antibody. In the autophagy-based degrader targeting a membrane protein, the nano secondary antibody that can bind to the membrane protein-targeting antibody is linked to a cationic polymer with autophagy-inducing properties to form a modular unit of the degrader. Since the nano secondary antibody can bind to numerous membrane protein antibodies derived from specific species, different membrane protein antibodies can be selected for the degradation of target proteins according to requirements without the need to couple each membrane protein antibody, which achieves the purpose of membrane protein degradation while greatly improving the convenience of use.

Classes IPC  ?

• A61K 39/44 - Anticorps liés à des supports
• A61P 35/00 - Agents anticancéreux

Abrégé

Provided in the present application are a combined linear rail device and an assembling method therefor. The combined linear rail device comprises a platform, a base and a guide rail. The platform comprises a platform module or a plurality of platform modules which are sequentially assembled in the length direction. The base is arranged on the platform and comprises a base module or a plurality of base modules which are sequentially assembled in the length direction; the guide rail is arranged on the base and comprises a guide rail module or a plurality of guide rail modules which are sequentially assembled in the length direction. The present application solves the problem in the prior art of difficulty in assembly of linear guide rails.

Classes IPC  ?

• F16B 7/00 - Assemblages de barres ou assemblages de tubes, p. ex. de section non circulaire, y compris les assemblages élastiques
• F16C 29/00 - Paliers pour pièces à déplacement uniquement linéaire

Abrégé

A use of a GPR1 as a target in preparing an endometriosis-related diagnostic and/or therapeutic formulation, relating to the technical field of biomedicine. The present invention provides a use of a GPR1 target as a diagnostic marker in preparing a reagent or kit for diagnosing endometriosis. The endometriosis is selected from one of uterosacral ligament endometriosis, peritoneal endometriosis, rectovaginal endometriosis, deep infiltrating endometriosis, and ovarian endometriosis. The present invention discovers that the expression of the GPR1 is significantly increased in endometriosis tissues and cells, indicating that the GPR1 can be used as a diagnostic marker for endometriosis. It has been discovered in in-vitro and in-vivo models that GPR1 knockout significantly inhibits the abilities of hEM15A cells to proliferate, migrate, and invade and the growth of ectopic foci in animals, indicating that the GPR1 can be used as a new intervention target for clinically treating endometriosis.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

An aberration-free laser spot scanning apparatus, comprising a resonant scanner (1), a first concave mirror (2), a second concave mirror (3), an X-axis galvanometer scanning mirror (4), a third concave mirror (5), a fourth concave mirror (6) and a Y-axis galvanometer scanning mirror (7) which are sequentially arranged in the direction of light beam propagation. Compared with existing laser spot scanning apparatuses that generally use a lens as an optical relay element between scanning mirrors, replacing the lens with a concave mirror to complete optical relay between scanning mirrors can avoid spherical aberration in a focusing transmission element, while also reducing the optical power loss generated by light transmission through a glass element, so that the aberration-free laser spot scanning apparatus can be applied to an optical microscopic imaging (e.g., laser confocal and two-photon imaging) system.

Classes IPC  ?

• G02B 21/00 - Microscopes
• G02B 26/10 - Systèmes de balayage

Abrégé

A rapid laser spot scanning control device, comprising a double-axis microelectromechanical system (MEMS) rapid scan mirror (1), a first lens (2), a second lens (3), an X-axis galvanometer scan mirror (4), a third lens (5), a fourth lens (6) and a Y-axis galvanometer scan mirror (7) which are sequentially arranged in the light beam propagation direction. The X-axis galvanometer scan mirror (4) and the Y-axis galvanometer scan mirror (7) are used for carrying out full-field scanning imaging in a whole imaging field-of-view range; the MEMS scan mirror (1) is used for carrying out rapid scanning imaging on sub-areas of a target position; and the X-axis galvanometer scan mirror (4) and the Y-axis galvanometer scan mirror (7) switch different sub-areas in an imaging filed-of-view. By integrating the MEMS scan mirror (1) and conventional galvanometer scan mirrors, the scanning speed and the flexibility of switching imaging sub-areas are superior to those of existing scanning devices based on the combination of galvanometer scan mirrors and resonant galvanometers, and the present invention is suitable for imaging detection of a quickly changing physiological process in large-field-of-view imaging.

Classes IPC  ?

• G02B 21/00 - Microscopes
• G02B 26/10 - Systèmes de balayage

Abrégé

The present application relates to a lymph node metastasis staging prediction method and apparatus, a computer device, and a storage medium. The method comprises: collecting a CT image and a digital pathological image of a patient; performing depth feature extraction on the CT image and the digital pathological image by means of a ResNet50 network and a ViT network, respectively, to obtain a first feature vector of the CT image and a second feature vector of the digital pathological image; combining the first feature vector and the second feature vector to obtain a fused feature vector; and inputting the fused feature vector into a fully connected neural network, and outputting a lymph node metastasis staging prediction result of the patient by means of the fully connected neural network. The present application uses a depth feature fusion strategy for a CT image and a digital pathological image to construct a lymph node metastasis staging prediction model, such that the generalization of the model can be improved while the prediction precision of the lymph node metastasis staging prediction model is improved.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux

Abrégé

A vapor exposure model experimental device, comprising: an exposure chamber (1), which is divided into a plurality of vapor compartments (101); an air intake mechanism (2), which is fixed in the exposure chamber, and which is provided with a plurality of air inlets (203) and a plurality of air outlets (204), each air inlet (203) being in communication with one corresponding vapor compartment (101), and each air outlet (204) being in communication with one corresponding vapor compartment (101); a vapor generator (3), which is in communication with the air inlets (203) of the air intake mechanism (2); and a camera (4), which is arranged above the exposure chamber (1) and used for observing the exposure chamber (1). The vapor exposure model experimental device enables vapor exposure experiments to be conducted by means of the exposure chamber (1) and the vapor generator (3), and the air intake mechanism (2) provides the same exposure condition for the vapor compartments (101), facilitating synchronous vapor experiments on different experimental subjects; thus, the device involves an easy operation while enabling online real-time observation of experimental subject behavior.

Classes IPC  ?

• A61D 7/04 - Dispositifs pour anesthésier les animaux au moyen de gaz ou vapeursDispositifs pour inhalations
• A61D 7/00 - Dispositifs ou méthodes pour l'introduction de remèdes, solides, liquides ou gazeux ou d'autres produits dans ou sur le corps des animaux

Abrégé

The present application relates to the field of behavior analysis. Provided are a behavior analysis method and apparatus, and an electronic device and a storage medium. The method comprises: acquiring an image sequence, wherein the image sequence comprises at least one image frame, and each image is generated during a process in which a vapor exposure apparatus delivers the same or different vapor to at least one test target; performing pose estimation on each test target in each image to obtain key point information of each test target under different exposure times; and on the basis of the key point information of each test target under different exposure times, performing quantitative analysis on the behavior of each test target under at least one vapor exposure condition to obtain a behavior difference result of each test target. The present application solves the problems in the related art of low efficiency and insufficient accuracy of behavior analysis.

Classes IPC  ?

• G06V 40/20 - Mouvements ou comportement, p. ex. reconnaissance des gestes

Abrégé

Disclosed is an expression method for CSTN3 protein, comprising: providing a humanized CSTN3 extracellular segment full-length gene as a target gene; linking the target gene to a mammalian cell secretory expression vector, so as to construct a recombinant expression vector containing the target gene; instantaneously transfecting a mammalian cell with the recombinant expression vector by means of mediation with a transfection reagent; and culturing the transfected mammalian cell. The method is characterized in that the recombinant CSTN3 protein can be obtained simply by collecting a cell supernatant and then performing affinity separation by means of a nickel column without the need of cell disruption. Also disclosed are a recombinant expression vector containing the humanized CSTN3 extracellular segment full-length gene and a recombinant HEK293F cell containing the mammalian cell secretory expression vector containing the humanized CSTN3 extracellular segment full-length gene. The present application achieves rapid, stable and efficient expression of the target protein CSTN3 and achieves a high level of protein folding expression and stable quality. In addition, the culture process only needs using a small amount of a serum-free culture medium, thereby achieving a low cost.

Classes IPC  ?

• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
• C12N 15/12 - Gènes codant pour des protéines animales
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères

Abrégé

The present application relates to the technical field of biological devices. Disclosed is a device for measuring nerve fiber action potentials. The device can not only synchronously measure the action potentials of all nerve fibers in a peripheral nerve, but can also slow down the inactivation rate of the peripheral nerve, thereby improving the stability of the measurement results. The device comprises a box, wherein a working chamber and a thermal insulation chamber below the working chamber are defined in the box; a vertical partition is provided in the working chamber; the vertical partition divides the working chamber into a stimulation chamber and a recording chamber; a stimulation electrode group is provided in the stimulation chamber; an oxygen-containing-liquid inlet and an oxygen-containing-liquid outlet are provided in side walls of the stimulation chamber; the oxygen-containing-liquid inlet is in communication with an oxygen-containing-liquid source via a peristaltic pump; a plurality of recording electrode groups are provided in the recording chamber, and are distributed in multiple layers; and the vertical partition plate can hold a peripheral nerve to be tested. The present application is intended to improve the performance of a nerve action potential measurement device.

Classes IPC  ?

• A61B 5/388 - Études de la conduction nerveuse, p. ex. détection du potentiel d’action d’un nerf périphérique
• G01R 29/12 - Mesure du champ électrostatique

Abrégé

A modular ultrasonic generation device and an ultrasonic manipulation method for microparticles. The modular ultrasonic generation device is configured to generate an acoustic field for manipulating the movement of a target object (300). The device comprises an ultrasonic transducer (100) and a modulation member (200); the ultrasonic transducer (100) is configured to generate a planar wave; the modulation member (200) is provided on a propagation path of the planar wave and located between the ultrasonic transducer (100) and the target object (300), and the modulation member (200) can modulate the planar wave into a target acoustic field for manipulating the target object (300) so as to drive the target object (300) to move along a set movement path; and the modulation member (200) comprises a plurality of unit modules (210) capable of modulating corresponding sub-acoustic fields, and the unit modules (210) are spliced to superimpose the sub-acoustic fields to form the target acoustic field. In the modular ultrasonic generation device, diversified acoustic fields for manipulation having different functions are realized by means of the splicing of the plurality of unit modules (210), and dynamic combination can be performed according to manipulation requirements in different application scenarios to form different modulation members (200), so as to modulate microparticle manipulation modes having different functions.

Classes IPC  ?

• B06B 3/00 - Procédés ou appareils spécialement adaptés pour transmettre des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore
• G10K 11/36 - Dispositifs pour transformer les ondes acoustiques de surface

Abrégé

A manufacturing method for a carbon-nanotube cold cathode (5), comprising the following steps: providing a positioning plate (1), the positioning plate (1) being provided with at least one positioning hole (11); providing a cold cathode substrate (2); embedding the cold cathode substrate (2) in the positioning hole (11); and fitting a screen printing mesh plate (3) onto the positioning plate (1), and using a screen printing method to print a carbon-nanotube slurry on the surface of the cold cathode substrate (2), so as to prepare a carbon-nanotube cold cathode (5). An X-ray tube electron gun assembly comprises the carbon-nanotube cold cathode (5). The manufacturing method for the carbon-nanotube cold cathode (5) uses the positioning plate (1) having a larger area for positioning, achieving accurate and reliable positioning and simple operation, and having low requirement for the appearance of the cold cathode substrate (2), thus achieving high applicability; using the positioning plate (1) for positioning not only increases the accuracy of an array pattern of the carbon-nanotube cold cathode (5), but also improves the array pattern quality and increases the reuse rate of the screen printing mesh plate (3).

Classes IPC  ?

• H01J 9/02 - Fabrication des électrodes ou des systèmes d'électrodes
• H01J 35/06 - Cathodes
• H01J 35/00 - Tubes à rayons X

Abrégé

A method for producing glucose and derivatives thereof by means of biotransformation with a recombinant yeast, which belongs to the technical field of synthetic biology. A construction method comprises any one of the following steps: i, knocking out metabolic pathway-related enzymes of glucose and derivatives thereof in a yeast strain; ii, enhancing or using an activity of synthetic pathway-related enzymes of glucose and derivatives thereof in the yeast strain; and iii, enhancing or using a capability of glucose and derivatives thereof in the yeast strain to enter and exit the yeast. Further provided are a recombinant yeast strain capable of producing glucose or derivatives thereof at a high yield and the use thereof in the conversion of a non-grain low-carbon carbon source. The low-carbon non-grain carbon source synthesized by means of using photoelectrocatalysis or traditional chemical industry is used as a substrate, and rapid preparation of food product raw materials glucose and derivatives thereof from the non-grain carbon source is realized by means of recombinant yeast cells.

Classes IPC  ?

• C12P 19/02 - Monosaccharides
• C07K 14/415 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de végétaux
• C12N 1/18 - Levure de boulangerieLevure de bière
• C12N 9/10 - Transférases (2.)
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12N 9/16 - Hydrolases (3.) agissant sur les liaisons esters (3.1)
• C12N 9/24 - Hydrolases (3.) agissant sur les composés glycosyliques (3.2)
• C12P 19/12 - Disaccharides
• C12P 19/26 - Préparation d'hydrates de carbone contenant de l'azote
• C12R 1/84 - Pichia
• C12R 1/865 - Saccharomyces cerevisiae

Abrégé

The use of a micro-lens chip (10) in particle tracking. A particle tracking apparatus (1) comprising a micro-lens chip (10). A particle tracking method for performing particle tracking by means of a micro-lens chip (10). The use of a micro-lens chip (10) in particle tracking performed by a particle tracking apparatus (1) by means of a particle tracking method.

Classes IPC  ?

• G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
• G02B 3/00 - Lentilles simples ou composées

Abrégé

The embodiments of the present application belong to the technical field of ultrasonic control. Provided are a movement control system, a movement control method, a movement control apparatus, and a device and a storage medium. The movement control method comprises: a signal acquisition device, a signal processing device and an ultrasonic control device. The signal acquisition device acquires a target electroencephalogram signal, and the signal processing device performs electroencephalogram feature processing on the target electroencephalogram signal. The electroencephalogram feature processing specifically comprises: using a pre-trained movement direction recognition model to perform movement direction classification on target electroencephalogram feature data in the target electroencephalogram signal, so as to obtain movement direction data, also using the target electroencephalogram feature data to obtain a movement step length, and generating a movement control signal on the basis of the movement direction data and the movement step length. On the basis of the movement control signal, the ultrasonic control device controls a target object to move in a target direction. Therefore, non-contact ultrasonic control based on electroencephalogram control is realized, thereby improving the universality of ultrasonic control.

Classes IPC  ?

• B25J 9/16 - Commandes à programme

Abrégé

The present invention relates to an anisotropic soft tissue cutting simulation method and apparatus. The method comprises: constructing a cutting simulation environment of a target soft tissue by combining particles and a background Eulerian grid; the background Eulerian grid acquiring physical quantity information on the basis of performing simulated shearing on the target soft tissue; calculating the elastic energy of the particles on grid nodes of the background Eulerian grid on the basis of physical quantities; and when the elastic energy exceeds the elastic energy limit that the target soft tissue can withstand and the target soft tissue undergoes shear fracture, the particles updating their own positions on the basis of the physical quantities. According to the present application, to realize deformation simulation of an anisotropic soft tissue, anisotropic elastic energy terms are introduced into an MPM to realize shear fracture simulation of the anisotropic target soft tissue, making the shear simulation of the target soft tissue more realistic.

Classes IPC  ?

• G06F 30/25 - Optimisation, vérification ou simulation de l’objet conçu utilisant des méthodes basées sur les particules

Abrégé

Provided are an expression cassette, an expression vector, a recombinant microorganism, a heterologous expression method of a non-ribosomal peptide synthetic gene cluster, and the use thereof. The expression cassette comprises a promoter, the non-ribosomal peptide synthetic gene cluster and a terminator which are linked tandemly in sequence, the non-ribosomal peptide synthetic gene cluster containing N synthetic genes linked tandemly in sequence, and N being a positive integer greater than or equal to 2. At least one ribosome binding site is provided between each two adjacent synthetic genes. The promoter, the terminator and the ribosome binding site are derived from Bacillus subtilis, thus reducing the difficulty in expressing the non-ribosomal peptide synthetic gene cluster in a heterologous expression host (Bacillus subtilis).

Classes IPC  ?

• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12N 15/81 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour champignons pour levures
• C12N 15/75 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour Bacillus
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12N 1/19 - LevuresLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12R 1/125 - Bacillus subtilis
• C12R 1/865 - Saccharomyces cerevisiae

Abrégé

Disclosed in the present invention are an adaptive temperature control system and method for a thermoelectric cooler based on transient supercooling. The system comprises: a temperature detection unit used for acquiring temperature information of a cold end of a thermoelectric cooler; a thermal load monitoring unit used for monitoring thermal load information of the thermoelectric cooler; a PID controller used for controlling and outputting a first current on the basis of the temperature information of the cold end and with an optimization goal of controlling the temperature of the cold end of the thermoelectric cooler to be a target temperature; a transient pulse controller used for controlling a current limit on the basis of the thermal load information; a feedforward controller used for adjusting an advanced control current on the basis of the thermal load information and outputting a second current; a limit output unit used for increasing a total current output limit of the first current and the second current to the current limit on the basis of the current limit generated by the transient pulse controller; and a power output unit used for driving the thermoelectric cooler on the basis of a current generated by the limit output unit. The present invention can significantly improve the thermal load resistance of the thermoelectric cooler and improve the precision and stability of temperature control.

Classes IPC  ?

• G05D 23/20 - Commande de la température caractérisée par l'utilisation de moyens électriques avec un élément sensible présentant une variation de ses propriétés électriques ou magnétiques avec les changements de température

Abrégé

The present application relates to the technical field of collection for medical waste, and relates to an embedded automatic disinfection negative pressure collecting apparatus and method for medical waste. The apparatus comprises a mounting part, a negative pressure maintaining module, and a lid opening module. The mounting part is nested and arranged on a barrel opening of a garbage can, the mounting part is provided with a throwing through hole, the throwing through hole is arranged corresponding to the barrel opening of the garbage can, and an accommodating space is formed inside the mounting part. The negative pressure maintaining module is disposed in the accommodating space, and the negative pressure maintaining module extends into the throwing through hole. The lid opening module is rotatably arranged on the mounting part. The mounting part is provided with a central control apparatus, and both the lid opening module and the negative pressure maintaining module are electrically connected to the central control apparatus. The mounting part can be embedded into a position above the garbage can and a negative pressure environment is formed in the garbage can, so that when the lid opening module is opened and medical waste is dumped into the garbage can, the smell in the garbage can is not inhaled by medical staff. Therefore, the problem that an existing garbage can on the market cannot be adapted to a negative pressure apparatus is solved.

Classes IPC  ?

• B65F 1/10 - Récipients à ordures avec moyens de remplissage, p. ex. sacs pneumatiques
• B65F 1/16 - Capots ou couvercles
• B65F 1/14 - Autres caractéristiques de structure

Abrégé

A method for separating an exosome from a heterologous expression cell or a primary culture cell, and a use of an exosome in biological analysis, relating to the technical field of biomedicine. The method for separating the exosome from the heterologous expression cell or the primary culture cell of the present invention comprises: carrying out differential centrifugation on a solution to be extracted that contains an exosome, then taking out a first supernatant, carrying out high-speed centrifugation again, respectively adding iodixanol into an obtained second supernatant and a precipitate, and carrying out spontaneous density gradient centrifugation to obtain a separated purified exosome. According to the present invention, an iodixanol spontaneous density gradient centrifugation method is innovatively used to successfully carry out separation and purification to obtain the exosome having high purity and high yield, and the separated exosome is used as an experimental development universal platform for researching a membrane protein structure and functional characteristics in an original ecological cell membrane environment, and is used for biological analysis, drug screening, and disease diagnosis and treatment.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• A61K 35/00 - Préparations médicinales contenant des substances ou leurs produits de réaction de constitution non déterminée

Abrégé

A preparation method for a perovskite solar cell module and a large-area uniform perovskite thin film. The structure of the perovskite thin film solar cell module can be divided into a substrate, a hole transport layer, an interface modification layer, a perovskite absorption layer, an electron transport layer, a hole blocking layer, and a back electrode from bottom to top. The perovskite absorption layer is prepared by increasing DMF pre-wetting. The problems of a thin film uniformity requirement and a hole defect in the preparation process of a p-i-n trans-structure large-area perovskite thin film solution method are solved.

Classes IPC  ?

• H10K 30/40 - Dispositifs organiques sensibles au rayonnement infrarouge, à la lumière, au rayonnement électromagnétique de plus courte longueur d'onde ou au rayonnement corpusculaire comprenant une structure p-i-n, ayant p. ex. un absorbeur pérovskite entre des couches de transport de charge de type p et de type n
• H01L 31/18 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives
• H10K 85/50 - Pérovskites organiquesPérovskites hybrides organiques-inorganiques [HOIP], p. ex. CH3NH3PbI3

Abrégé

Provided is a negative electrode active material for a sodium ion battery. The negative electrode active material comprises reticulated hard carbon, hard carbon particles, and active metal particles; and the hard carbon particles and the active metal particles are distributed in the reticulated hard carbon and are fixed by the reticulated hard carbon. The production cost of the negative electrode active material for a sodium ion battery is reduced, and the capacity, the cycle performance and the rate performance of the negative electrode active material are improved. Further provided are a preparation method for and a use of the negative electrode active material for a sodium ion battery.

Classes IPC  ?

• H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
• H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
• H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p. ex. au magnésium ou à l'aluminium

Abrégé

33. The method comprises: subjecting the metal halide perovskite single crystal to wire cutting, grinding and polishing, and polishing the metal halide perovskite single crystal by utilizing a polishing paste and diamond oil. Moreover, without any damage to the surface of the perovskite single crystal and the charge collection efficiency of the perovskite single crystal, the requirement for the surface roughness of the perovskite single crystal during machining is met, and therefore the performance of a corresponding photovoltaic device is improved without any increase in the preparation difficulty of surface polishing of the perovskite single crystal.

Classes IPC  ?

• B28D 5/04 - Travail mécanique des pierres fines, pierres précieuses, cristaux, p. ex. des matériaux pour semi-conducteursAppareillages ou dispositifs à cet effet par outils autres que ceux du type rotatif, p. ex. par des outils animés d'un mouvement alternatif

Abrégé

An NK cell drug delivery system, a preparation method therefor and a use thereof, relating to the field of drugs. The NK cell drug delivery system comprises activated NK cells and drug-loaded nanoparticles linked to the surfaces of the activated NK cells; the activated NK cells are NK cells containing sulfhydryl on the surfaces; maleimide groups or sulfhydryl groups are contained on the surfaces of the drug-loaded nanoparticles; the drug-loaded nanoparticles are linked to sulfhydryl on the surfaces of the activated NK cells by means of the maleimide groups or the sulfhydryl groups; by means of the NK cells linked to sulfhydryl by means of the maleimide groups or the sulfhydryl groups, and the drug-loaded nanoparticles, the NK cell drug delivery system has high targeting performance and low biotoxicity on cells or tissues of brain diseases, and significantly improves the effect of treating brain diseases.

Classes IPC  ?

• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
• A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
• A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux

Abrégé

A porous diamond coating, and a preparation method therefor and the use thereof. The porous diamond coating comprises a metal matrix, wherein a silicon carbide composite intermediate layer (3) is provided on the surface of the metal matrix, diamond grains (4) dispersed apart from each other are embedded in the silicon carbide composite intermediate layer (3), and gaps and a porous structure are formed among the dispersed diamond grains (4), thereby achieving an effect of preventing blockages caused by abrasive dust. When being used for a cutter, the porous diamond coating is good in terms of machining quality, high in terms of machining precision, low in terms of wear rate and long in terms of service life. In addition, the porous diamond coating is not limited by the shape of a tool, can achieve rapid controllable deposition on a miniature precision tool in any complex shape, and has the advantages of a wide application range, high precision, low cost, etc. Further provided are a preparation method for and the use of the porous diamond coating.

Classes IPC  ?

• C23C 16/02 - Pré-traitement du matériau à revêtir

Abrégé

Disclosed in the present invention is a secrecy rate optimization method for a simultaneous wireless information and power transfer system. The method comprises: constructing a simultaneous wireless information and power transfer system, which includes an intelligent reflecting surface apparatus, an access point, a plurality of legitimate users and a plurality of eavesdroppers, wherein the intelligent reflecting surface apparatus is provided with a plurality of reflecting elements, and adding artificial noise to an information signal transmitted by the access point; for the simultaneous wireless information and power transfer system, establishing a secrecy rate optimization problem, and in the secrecy rate optimization problem, taking interference between the users into consideration and describing channel state information of the eavesdroppers; and for the secrecy rate optimization problem, jointly optimizing a power splitting ratio, transmission beamforming, a covariance matrix for the artificial noise, and a phase shift matrix for the intelligent reflecting surface apparatus, wherein the power splitting ratio is used for limiting a legitimate user to splitting a power into an information decoding part and an energy harvesting part. The present invention is more applicable to an actual communication scenario, reduces the eavesdropping rate, and thus increases the overall rate of a system.

Classes IPC  ?

• H04W 12/02 - Protection de la confidentialité ou de l'anonymat, p. ex. protection des informations personnellement identifiables [PII]

Abrégé

00 into a spatial discretization representation; acquiring a correspondence between coarse and fine networks in the multi-level coarse and fine mesh representation (I); and performing correction calculation on the correspondence between the coarse and fine networks to obtain a node motion information iteration process of the coarse and fine meshes. The method significantly reduces network input while maximizing the retention of mesh space information, and reduces calculation resource consumption.

Classes IPC  ?

• G06F 30/10 - CAO géométrique
• G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

An experimental data processing method and apparatus, and a system, relating to the field of automatic data processing. The method comprises: sending a task preparation sequence instruction to a data computation system, so that the data computation system, on the basis of the task preparation sequence instruction, creates a task-related computation process, creates a data object in the computation process, and assigns an initial value (501); sending a data acquisition instruction to a device control end, and receiving data acquired by the device control end operating an experiment device; on the basis of the acquired data, generating a data modification instruction to the data computation system, so that the data computation system assigns a value to the data object in the related task computation process (502); sending a data computation instruction to the data computation system, so that, on the basis of the data computation instruction, the data computation system performs computation on data of the related task computation process (503); and sending a data output instruction to the data computation system, so as to, on the basis of the data output instruction, store in a data object database the data of the related computation process (504). According to the described method, a full-service process can be implemented. In addition, the method has the advantages of being easy to use and easy to learn and being versatile.

Classes IPC  ?

• G06F 16/25 - Systèmes d’intégration ou d’interfaçage impliquant les systèmes de gestion de bases de données
• G06F 16/2458 - Types spéciaux de requêtes, p. ex. requêtes statistiques, requêtes floues ou requêtes distribuées
• G06F 9/451 - Dispositions d’exécution pour interfaces utilisateur

Abrégé

The present application relates to the technical field of image processing. Provided are a stent identification method and apparatus, and a stent reconstruction method and apparatus. The stent identification method comprises: acquiring an original intravascular ultrasound (IVUS) image; performing anisotropic diffusion filtering on the original IVUS image to obtain an IVUS image in which stent signals are enhanced; processing the IVUS image in which the stent signals are enhanced, so as to form a binarized mask image that only includes the stent signals; and obtaining a stent identification result for the original IVUS image on the basis of the binarized mask image and the original IVUS image. Since IVUS has a greater imaging depth, even when the depth of a stent in a blood vessel is increased, stent signals can still be detected by means of IVUS, so that a situation where stents cannot be identified does not occur.

Classes IPC  ?

• G06V 20/60 - Type d’objets
• G06T 7/00 - Analyse d'image
• G06T 17/00 - Modélisation tridimensionnelle [3D] pour infographie
• G06V 10/28 - Quantification de l’image, p. ex. seuillage par histogramme visant à discriminer entre les formes d’arrière-plan et d’avant-plan
• G06V 10/30 - Filtrage de bruit

Abrégé

An animal behavior pattern mining system, a method, a computer device, and a storage medium. The system comprises a PC device (10) and an experiment box body (20); an infrared touch screen (25), a transparent box body (26), a camera (27), a thermal infrared probe (28) and a brain endoscope (29) are further separately provided in the experiment box body (20); the transparent box body (26) is used for placing an experimental animal; the infrared touch screen (25), the camera (27) and the thermal infrared probe (28) are respectively used for acquiring trajectory data, video images, and body temperature data of the experimental animal; the brain endoscope (29) is used for acquiring neuron signals of the experimental animal; and the PC device (10) is used for acquiring the behavior pattern category of the experimental animal on the basis of the trajectory data, the video images, the body temperature data and the neuron signals.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 5/369 - Électroencéphalographie [EEG]
• A61B 5/01 - Mesure de la température de parties du corps

Abrégé

A miniature drill bit, and a preparation method therefor and the use thereof. The miniature drill bit comprises a drill bit substrate and a superhard wear-resistant diamond coating arranged on a surface of the drill bit substrate, wherein the diameter of the drill bit substrate is 0.08-4 mm. The diameter of the drill bit substrate makes it an extremely-small-diameter drill bit, and a uniform diamond coating is further arranged on the extremely-small-diameter drill bit; therefore, the drill bit has good drilling machining performance and meets the development and machining trend of a packaging substrate. The invention solves the problems of most of the traditional diamond-coated miniature drill bits having a diameter of 1 mm or more, and having difficulties in terms of adapting to packaging substrates having a smaller size and finer holes.

Classes IPC  ?

• B26F 1/16 - Perforation par un ou plusieurs outils du type foret
• C23C 16/27 - Le diamant uniquement
• C23C 16/02 - Pré-traitement du matériau à revêtir
• C23G 1/14 - Nettoyage ou décapage de matériaux métalliques au moyen de solutions ou de sels fondus avec des solutions alcalines

Abrégé

A window structure capable of being overlapped and turned over, comprising: a frame; a first window body, which is connected to the frame in a turnover manner; a second window body, which is slidably connected to the first window body, wherein by means of sliding the second window body along the first window body, the second window body and the first window body are overlapped or extended; and a turnover driver, which is connected to the frame and the first window body and used for driving the overlapped first window body and second window body to turn over relative to the frame. The window structure capable of being overlapped and turned over in the present application can be opened by means of both sliding and turning over, such that the window structure can cover a large spatial range when same is opened.

Classes IPC  ?

• E06B 3/50 - Aménagements des battants caractérisés par le genre de mouvementAménagements des battants modèles dans les ouverturesCaractéristiques des battants ou châssis ayant trait uniquement au genre de mouvement du battant pour plusieurs genres de mouvement
• E06B 3/52 - Battants nécessitant une manœuvre de levée avant l'ouverture
• E05C 17/60 - Dispositifs pour le maintien des battants coulissants en position d'ouverture
• E05C 19/16 - Dispositifs maintenant le battant par attraction magnétique ou électro-magnétique
• E05F 1/10 - Appareils de fermeture ou d'ouverture pour battants, non prévus ailleurs dans la présente sous-classe actionnés par ressort pour battants pivotants

Abrégé

A preparation method for a sodium iron sulfate polyanion positive electrode material, and a device, relating to the technical field of secondary battery material manufacturing. The provided preparation method comprises: performing wet ball milling on sodium sulfate and ferrous sulfate and sintering the resulting mixture. The sintering is performed in a protective atmosphere having a flow rate of 0.024 to 20 mm/s; a moisture absorbent is present in the sintering environment, and the moisture absorbent is located downstream of the protective atmosphere; and the sintering comprises: sequentially performing constant-temperature treatment at 60-120°C, 150-250°C, and 300-380°C. By means of the provided preparation method, the number of instruments used can be effectively reduced, the number of steps of the preparation method is reduced, and finally, the preparation costs are reduced. Also provided is a device for implementing the preparation method.

Classes IPC  ?

• H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFyEmploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p. ex. phosphates, silicates ou borates

Abrégé

Provided is an in-vitro electrophysiological experiment method. The method comprises: injecting into a target tissue or organ an rAAV expressing a low-abundance fluorescent protein, the genome of the rAAV expressing a low-abundance fluorescent protein containing any one among the following a)-c): a) a promoter sequence, a fluorescent protein gene sequence and a PEST sequence; b) a promoter sequence, a fluorescent protein gene sequence and an ecDHFR DD sequence; and c) a TRE promoter sequence and a fluorescent protein gene sequence, the TRE promoter sequence being located at the upstream of the fluorescent protein gene sequence; and when the fluorescent protein has been expressed for a period of time, performing an in-vitro electrophysiological experiment on the target tissue or organ. The rAAV expresses a low-abundance fluorescent protein, the accumulation of fluorescent proteins in cells is reduced, the cytotoxicity is reduced, and the influence on experimental results is relatively small. In addition, low-abundance fluorescent proteins make cells easier to observe and distinguish from other fluorescent cells in the surrounding area in experiments.

Classes IPC  ?

• G01N 33/483 - Analyse physique de matériau biologique
• G01N 21/64 - FluorescencePhosphorescence
• C12N 15/864 - Vecteurs parvoviraux
• C12N 15/65 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression utilisant des marqueurs

Abrégé

A composite carbon material, and a preparation method therefor and a use thereof. The composite carbon material comprises activated carbon and a soft carbon layer covering the surface of the activated carbon; the activated carbon is selected from at least one of coal-based activated carbon, coconut shell activated carbon, and bamboo charcoal activated carbon; the soft carbon layer comprises sodium storage active pores, and the soft carbon layer is prepared by melting a soft carbon precursor, and then coating the surface of activated carbon with the soft carbon precursor and carrying out primary calcination. The material is easy to prepare and environmentally friendly, has low raw material costs, a small specific surface area, abundant sodium storage active pores and a stable structure, and can fully exert the matrix and mass transfer effects of activated carbon; because of the fluidity of the soft carbon precursor and the activity of soft carbon, pores in the surface of activated carbon are effectively converted into the sodium storage active pores; and a sodium-ion battery prepared by using the composite carbon material as a negative electrode active material can have the advantages of high specific capacity, high initial coulombic efficiency, good cycle reversibility, good long-cycle stability, good rate performance, etc.

Classes IPC  ?

• H01M 4/36 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs
• H01M 4/587 - Matériau carboné, p. ex. composés au graphite d'intercalation ou CFx pour insérer ou intercaler des métaux légers
• H01M 4/04 - Procédés de fabrication en général
• H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
• H01M 4/133 - Électrodes à base de matériau carboné, p. ex. composés d'intercalation du graphite ou CFx

Abrégé

2222.

Classes IPC  ?

• C25B 11/032 - Électrodes à diffusion de gaz
• C25B 3/07 - Composés contenant au moins un atome d’oxygène
• C25B 3/26 - Réduction du dioxyde de carbone
• C25B 11/048 - Composés organiques

Abrégé

The present application provides a preparation method for a gas diffusion electrode for electrocatalytic CO2 reduction to CO, comprising: mixing a conductive polymer monomer solution and a metal salt solution at a molar ratio of 100:1 to 1:100 and adding a dispersant to form a mixed solution; and transferring the mixed solution onto a substrate, and reacting at a temperature ranging from -30°C to 50°C for 1-48 h to obtain a gas diffusion electrode. According to the present application, a metal-conductive polymer gas diffusion electrode is formed by means of in-situ growth of conductive polymer monomers self-initiated by metal ions; due to the characteristics of the conductive polymer, the gas diffusion electrode can provide more nucleation sites, reducing the usage amount of metal while achieving similar catalytic effects; secondly, the special structure of the conductive polymer improves the electron transfer rate and the CO2 adsorption capacity on the electrode surface, helping to improve the product selectivity; and finally, the conductive polymer is an organic macromolecular long-chain structure, and the substrate, metal particles and metal-ligand complex to which the conductive polymer is bound can be stabilized by means of cross-linking, thereby improving the stability of the electrode.

Classes IPC  ?

• C25B 11/032 - Électrodes à diffusion de gaz
• C25B 3/07 - Composés contenant au moins un atome d’oxygène

Abrégé

Provided in the present invention is a preparation method for an Fe-Co-Ni-Cu-Zn high-entropy sensing material. The Fe-Co-Ni-Cu-Zn high-entropy sensing material is obtained by preparing an electroplating solution, adjusting the concentration and pH value of an electrolyte, and preparing a sensitive material from Fe, Co, Ni, Cu and Zn by means of an electrochemical method. The preparation method is simple and convenient to operate, and relatively low in terms of cost and energy consumption; and the elemental composition, structural morphology, performance, etc., of the high-entropy alloy can be easily controlled by changing the deposition parameters (time, temperature, etc.) of electrochemical deposition. The Fe-Co-Ni-Cu-Zn high-entropy sensing material prepared in the present application can be used as a sensing electrode to test urea and glucose solutions having different concentrations, and has high detection precision, good stability and high sensitivity.

Classes IPC  ?

• C25D 3/56 - Dépôt électrochimiqueBains utilisés à partir de solutions d'alliages
• C25D 5/34 - Prétraitement des surfaces métalliques à revêtir de métaux par voie électrolytique
• C25D 7/00 - Dépôt électrochimique caractérisé par l'objet à revêtir
• G01N 27/12 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de l'absorption d'un fluideRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de la réaction avec un fluide

Abrégé

A kit for detecting trace nitrite, a detection system and a related method. The kit comprises a nitrite detection reagent, the nitrite detection reagent comprising the following component raw materials in parts by mass: 0.5-50.0 parts of sulfanilic acid, 0.1-20.0 parts of hydrochloride naphthodiamide, 10.0-90.0% of a weighting agent, 1.0-60.0 parts of a masking agent and 0-10.0 parts of an accelerator. Compared with conventional methods or other measurement forms, the kit, the detection system and the related method offer more convenient use, easy formulation, safe and simple operation and low cost, and do not require specialized technicians for measurement. Reagents used in the kit are all common chemical reagents, which are safe, reliable and low in price.

Classes IPC  ?

• G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur

Abrégé

The present invention provides a kit for detecting nitrate in water, a detection system, and related methods. A first aspect of the present invention provides a kit for detecting nitrate in water. The kit comprises a nitrate detection reagent. The nitrate detection reagent comprises the following component raw materials in parts by mass: 0.1-10.0 parts of a reducing agent, 0.5-50.0 parts of p-aminobenzene sulfonic acid, 0.1-20.0 parts of N-(1-naphthyl)ethylenediamine dihydrochloride, 1.0-60.0 parts of a masking agent, 10.0-90.0 parts of a weighting agent, and 0-10.0 parts of an accelerant. According to the present invention, the reagent in the kit discolors immediately upon contact with nitrate, without the need for any complex analysis device, thereby realizing low-cost, instant and trace detection of nitrate. The reagent allows for simple and convenient operation, high sensitivity, and low costs, thereby providing an effective technical means for the field of detection of nitrate ions in water. The detection reagent shows a low detection limit (visual detection limit of 0.1 mg/mL) and extremely high selectivity for nitrate, thereby guaranteeing that the present invention can be applied to detect nitrate in water.

Classes IPC  ?

• G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur

Abrégé

Disclosed in embodiments of the present invention are a pathological image analysis method and apparatus. The method comprises: acquiring a pathological image data set, pathological images having different magnifications; respectively cutting the pathological images to obtain a plurality of image blocks in the pathological images; performing feature extraction on the image blocks to obtain image features of the image blocks, and performing feature fusion on the image features of the image blocks on the basis of the correspondence between the image blocks to obtain multi-magnification features of the image blocks; constructing a panoramic image on the basis of the image blocks having different magnifications, a spatial positional relationship of the image blocks in the pathological images to which the image blocks belong, and the multi-magnification features of the image blocks; inputting the panoramic image into a constructed context information perception model to learn graph structure information and context information in the pathological images, so as to obtain an analysis result of the pathological image data set; and applying the analysis result to a target task. The present invention solves the problem in the prior art of low accuracy caused by failure in full acquisition of feature information.

Classes IPC  ?

• G06T 7/00 - Analyse d'image

Abrégé

Disclosed in the present invention is a control system for a micro-nano robot magnetic control platform. The system is arranged in a main control computer and is connected to a magnetic control platform terminal device. The system comprises a main control unit, a display unit, a magnetic field parameter setting unit, a camera parameter setting unit, a user-defined magnetic field setting unit, a keyboard operation unit, a micro-nano robot object detection unit, a magnetic field measurement unit, a printing output unit and a magnetic control platform state unit. By coordinating the functions and interactions of the units, the present invention helps to set magnetic field parameters, monitor the states of motion of micro-nano robots in real time, communicate with micro-nano robot magnetic control platform terminals and comprehensively calculate and store magnetic field sensor data, can control magnetic control platforms to generate any magnetic field type, and controls the magnetic control platforms by means of keyboard keys, so as to accurately and visually control the micro-nano robots.

Classes IPC  ?

• B25J 9/16 - Commandes à programme
• B25J 7/00 - Micromanipulateurs
• B25J 13/00 - Commandes pour manipulateurs

Abrégé

A hard carbon negative electrode material as well as a preparation method therefor and a use thereof. The hard carbon negative electrode material comprises a hard carbon base material, heteroatoms and metal monoatoms, wherein the metal monoatoms are doped into the hard carbon base material by means of the heteroatoms, the heteroatoms comprise at least one of N, P or S, and the metal monoatoms are metal monoatoms that can undergo an alloying reaction with sodium. The metal monoatoms are doped into the hard carbon base material by means of covalent (chemical bond) interactions with other heteroatoms, so that the doping of single atoms is achieved, thereby improving the overall capacity and rate capability of a sodium ion battery at normal temperature, and ensuring the capacity retention rate of the sodium ion battery under a low temperature condition.

Classes IPC  ?

• H01M 4/36 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs
• H01M 4/583 - Matériau carboné, p. ex. composés au graphite d'intercalation ou CFx
• H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
• H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
• C01B 32/05 - Préparation ou purification du carbone non couvertes par les groupes , , ,

Abrégé

Disclosed in the present invention are a GPU feature mining and analysis method and system based on computer microarchitecture independence. The method comprises: building a target instrumentation library, analyzing a calling sequence of a target application program, and extracting a plurality of levels of performance features, wherein the performance features are high-level features of a program and are independent of a microarchitecture of a processor; analyzing a correlation between the performance features and execution performance of the target application program; and outputting an analysis result according to the obtained correlation, wherein the analysis result reflects a performance bottleneck of the target application program and a corresponding optimization suggestion. The present invention can help developers to adjust and optimize application programs, so as to fully use computing capabilities of GPUs.

Classes IPC  ?

• G06F 9/38 - Exécution simultanée d'instructions, p. ex. pipeline ou lecture en mémoire

Abrégé

Provided is a drug for treating rheumatoid arthritis, the drug comprising a gene therapy vector, and the gene therapy vector comprising a nucleic acid sequence encoding quinolinate phosphoribosyltransferase (QPRT). The provided drug provides prolonged or sustained QPRT in vivo, which can restore or enhance the capability of cells producing NAD+ and regulate processes in secretion pathways, thereby preventing pathological secretion of cytokines, stopping the inflammatory progression at the origin, and effectively avoiding immune response, neovascularization and tissue destruction in joints. The provided drug based on gene therapy can improve spatial and temporal distribution, improve the treatment effect and reduce side effects; the drug achieves prolonged or sustained QPRT release, and thus has long efficacy; and, along with the prolonged expression of QPRT, the dosage of the drug can be reduced.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• C12N 9/10 - Transférases (2.)
• A61K 38/45 - Transférases (2)
• A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
• A61P 37/02 - Immunomodulateurs
• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

A variable-stiffness magnetic drive catheter, which relates to the technical field of medical instruments. It is not only possible to improve the steering flexibility of the catheter, but also to ensure that the overall maximum stiffness can meet the requirements of advancing, sampling and other operations and also improve the steering flexibility and controllability of the catheter. The variable-stiffness magnetic drive catheter comprises a main rigid tube (1), a hollow flexible tube (2), a limit tube (3) and a magnetic component, which are sequentially arranged in an axial direction, wherein a magnetic spiral tube (5) is sleeved on the main rigid tube (1); the main rigid tube (1) has an inner diameter and an outer diameter equal to those of the hollow flexible tube (2); the limit tube (3) has an inner diameter equal to that of the main rigid tube (1), and has an outer diameter greater than that of the magnetic spiral tube (5); the main rigid tube (1), the hollow flexible tube (2) and the limit tube (3) are all made of soft materials, and the main rigid tube (1), the limit tube (3) and the magnetic component each have a stiffness greater than that of the hollow flexible tube (2); and the magnetic spiral tube (5) can spirally move forward or backward on a surface of the main rigid tube (1) and a surface of the hollow flexible tube (2), thereby improving the performance of the catheter.

Classes IPC  ?

• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
• A61M 25/00 - CathétersSondes creuses

Abrégé

A kit for detecting COD, and a preparation method therefor and the use thereof. The kit for detecting COD comprises a reagent tube loaded with a COD detection reagent, and a standard colorimetric card, wherein the COD detection reagent comprises potassium permanganate, a strong alkaline reagent and a weighting agent. The strong alkaline reagent comprises one of or a mixture of sodium carbonate, sodium bicarbonate and sodium phosphate; and the weighting agent comprises one of or a mixture of calcium carbonate, sodium sulfate and potassium sulfate. The kit is based on a potassium permanganate method, wherein reducing substances in water are oxidized under alkaline conditions, and manganese in different valence states is obtained in the case of different amounts of the reducing substances, thereby presenting different colors. The kit has the advantages of no need for instruments and devices, low cost, convenience, rapidness, flexibility, stability, etc., is simple in terms of actual operation, causes little pollution to a laboratory environment, and can be widely used.

Classes IPC  ?

• G01N 33/18 - Eau
• G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur

Abrégé

A use of a CD317 siRNA combined with an AMPK inhibitor or an AMPK siRNA in tumor treatment, relating to the technical field of biomedicines. Provided is a use of a CD317 siRNA or CD317 inhibitor combined with an AMPK inhibitor or an AMPK siRNA in the preparation of a drug for treating tumor diseases. The CD317 siRNA or CD317 inhibitor inhibits CD317 expression by means of gene silencing or gene editing, or performs targeted degradation on a CD317 protein by means of PROTAC and LYTAC technologies. The expression of cancer cell CD317 is reduced by means of the CD317 siRNA or CD317 inhibitor, thereby inhibiting an AMPK signal, enhancing the sensitivity of tumor cells to the AMPK inhibitor. A combination of the CD317 inhibitor and the AMPK inhibitor can significantly promote tumor cell death, providing a new anti-tumor method.

Classes IPC  ?

• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61P 35/00 - Agents anticancéreux

Abrégé

222 by water can be greatly improved, and the treated surface can achieve good hydroxylation, thereby greatly reducing the contact angle between same and water; the contact angle is relatively large after the anti-fingerprint film is coated, thereby effectively improving the hydrophobicity and friction resistance of the anti-fingerprint film; and the plasma treatment process is simple, energy-saving, environmentally friendly, pollution-free and highly efficient, and takes a short period of time, thus providing an important approach for achieving large-scale treatment and improvement of the friction resistance of the anti-fingerprint film.

Classes IPC  ?

• C03C 17/32 - Traitement de surface du verre, p. ex. du verre dévitrifié, autre que sous forme de fibres ou de filaments, par revêtement par des matières organiques avec des résines synthétiques ou naturelles
• C03C 23/00 - Autres traitements de surface du verre, autre que sous forme de fibres ou de filaments

Abrégé

The present invention relates to a modified bacterium having an anti-tumor activity. The bacterium contains a hypoxia-regulated lipopolysaccharide (LPS) gene expression cassette containing a gene involved in LPS biosynthesis or transport or a gene encoding a murein lipoprotein which is controlled by a first strictly hypoxia-inducible promoter. The bacterium further contains an essential gene expression cassette controlled by a strictly hypoxia-inducible promoter; and at least one gene or a functional expression product thereof that participates or regulates the endogenous response pathway against oxidative stress is deleted from the bacterium. The present invention further relates to a pharmaceutical composition containing the modified bacterium, and the anti-tumor use thereof.

Classes IPC  ?

• C12N 15/74 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C12N 1/36 - Adaptation ou atténuation de cellules
• A61P 35/00 - Agents anticancéreux

Abrégé

Provided are a fusion protein, comprising an antibody that binds to a neutrophil or an antigen-binding fragment thereof, and a cytotoxin or an active fragment thereof. Also provided are modified bacteria having anti-tumor activity and expressing the fusion protein, the antibody or the antigen-binding fragment thereof, or the toxin or the active fragment thereof in a low-oxygen environment (such as a tumor). Also provided are a pharmaceutical composition comprising the modified bacteria and an anti-tumor use thereof.

Classes IPC  ?

• C07K 16/46 - Immunoglobulines hybrides
• C07K 16/32 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des produits de traduction des oncogènes
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• A61K 35/74 - Bactéries
• A61P 35/00 - Agents anticancéreux
• C07K 19/00 - Peptides hybrides
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger

Abrégé

A learning-based AR-assisted dental treatment automatic calibration and navigation method, comprising: using a virtual reality display device to acquire a 3D mandible model of a target; inputting the 3D mandible model into a trained feature point detection network to identify a plurality of corresponding feature points; aligning the plurality of feature points with feature points of a corresponding real 3D mandible model so as to calibrate and navigate onto the real model the virtual model under the virtual reality display device, wherein the feature points of the real 3D mandible model are detected by using a depth camera; and on the basis of a multi-feature iterative nearest point algorithm, combining a virtual environment and the real environment to complete the display of the virtual projection in the real environment. The method improves the efficiency and accuracy of automatic calibration and navigation of dental treatment.

Classes IPC  ?

• A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
• A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre

Abrégé

A transient response time determination method and apparatus, a device, and a storage medium. The transient response time determination method comprises: on the basis of transient response time of a signal conditioning module, transient response time of signal amplitude processing, transient response time of signal phase processing, first transmission time, and second transmission time, determining the slowest transient response time and the fastest transient response time of an amplitude link and the slowest transient response time and the fastest transient response time of a phase link; and on the basis of the slowest transient response time and the fastest transient response time of the amplitude link and the slowest transient response time and the fastest transient response time of the phase link, determining average transient response time of the amplitude link, average transient response time of the phase link, and delay time of a delay module.

Classes IPC  ?

• G01R 33/58 - Étalonnage des systèmes d'imagerie, p. ex. utilisant des sondes d'essai
• G01R 33/54 - Systèmes de traitement du signal, p. ex. utilisant des séquences d'impulsions
• G01R 33/36 - Détails électriques, p. ex. adaptations ou couplage de la bobine au récepteur
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique

Abrégé

A kit/test paper for detecting ammonia nitrogen, and a detection system and a related method thereof. A reagent in the kit/test paper comprise the following raw materials in parts by mass: 50-500 parts of a buffering agent, 0-500 parts of a masking agent, 0-500 parts of a stabilizer, 50-500 parts of a color developing agent, 2-100 parts of an oxidizing agent, and 1-100 parts of a catalyst. The specification of the reagent is 0.1 g per tube. The preparation process is simple, no special environmental requirement is required, no special three-waste pollution is caused, the cost is low, the detection steps are simple, the determination is more accurate, the color developing time is short, and the mobility is high. The reagents used are common chemical reagents, are safe and reliable, and have low price. The kit/test paper has a wide application range, and can be used for measuring the content of ammonia nitrogen in water bodies such as chemical wastewater, surface water, urban wastewater recycling-landscape environment water and urban miscellaneous water, especially for environmentally friendly monitoring of ammonia nitrogen.

Classes IPC  ?

• G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur

Abrégé

An effect of cordycepin in the field of fat protection, specifically an application of cordycepin in the preparation of fat protection products in the field of treatment of mental illness or sub-healthy mental state, the therapeutic dose is 25 mg cordycepin per kilogram of body weight. 25 mg/kg cordycepin can increase the weight reduction of white adipose tissue (sWAT) and perirenal white adipose tissue (pWAT) induced by stress, significantly reduce the abundance of Prevotellaceae UCG-001, increase the abundance of Desulfovibrio, and have an anti-anxiety or depression tendency.

Classes IPC  ?

• A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p. ex. adénosine, acide adénylique
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• A61P 25/22 - Anxiolytiques
• A61P 25/24 - Antidépresseurs
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• A61P 25/20 - HypnotiquesSédatifs

Abrégé

A sodium iron sulfate, and a preparation method therefor and a use thereof, relating to the technical field of secondary battery materials. The preparation method comprises: carrying out microwave solvothermal reaction on a mixed solution of a sodium source, an iron source, a sulfur source and an antioxidant, wherein during the microwave solvothermal reaction, the temperature is sequentially maintained at temperatures T1, T1', T2, T2' and T3, the temperatures T1, T2 and T3 are separately independently selected from 200-350°C, and the temperatures T1' and T2' are separately independently selected from 100-180°C. According to the preparation method, sodium iron sulfate having particle size gradation can be prepared, and the tap density of the sodium iron sulfate is improved, thereby improving the high-rate capacity and the high-rate cycle performance when the sodium iron sulfate is used as a sodium ion battery positive electrode material.

Classes IPC  ?

• H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFyEmploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p. ex. phosphates, silicates ou borates
• C01G 9/00 - Composés du zinc
• H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p. ex. au magnésium ou à l'aluminium

Abrégé

A cuffless blood pressure monitoring system, which relates to the technical field of blood pressure monitoring. The system comprises: a symmetrical dual-channel PPG collection apparatus (101), a feature extraction module (102), and a blood pressure prediction model (103), wherein the symmetrical dual-channel PPG collection apparatus (101) comprises a light-emitting diode, and a first photoelectric detector and a second photoelectric detector, which are symmetrically distributed at two sides of the light-emitting diode; the symmetrical dual-channel PPG collection apparatus (101) is configured to acquire a dual-channel pulse signal; an input end of the feature extraction module (102) is connected to an output end of the symmetrical dual-channel PPG collection apparatus (101); the feature extraction module (102) is configured to extract morphological features and calculation features from the dual-channel pulse signal; an input end of the blood pressure prediction model (103) is connected to an output end of the feature extraction module (102); and the blood pressure prediction model (103) is configured to predict diastolic pressure and systolic pressure according to the morphological features and the calculation features. The symmetrical dual-channel PPG collection apparatus (101) has a small size, low cost and high sensitivity, and a non-invasive, continuous and wearable cuffless blood pressure monitoring apparatus is achieved.

Classes IPC  ?

• A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins

Abrégé

A method for manufacturing an acoustic microfluidic chip, and an acoustic microfluidic device. A phononic crystal plate and a microfluidic cavity are cleaned and then dried, and the phononic crystal plate and the microfluidic cavity are connected by means of a thin film layer to form an acoustic microfluidic chip. The present invention has strong binding force and flexible design, avoids liquid leakage, and facilitates installation.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes