Abrégé

EDD TPNTPRREDD NTPRR, is compared to a pre-set target ratio value and, if the comparison reveals a difference therebetween, an adjusted value of the dispersion electric field sufficient reduce the difference is applied across the analytical gap.

Classes IPC  ?

• G01N 27/624 - Spectrométrie de mobilité ionique différentielle [DMS]Spectrométrie de mobilité ionique à haut champ asymétrique [FAIMS]
• G01N 27/623 - Spectrométrie de mobilité ionique combinée à la spectrométrie de masse

Abrégé

A method of analyzing ions comprising generating ions from a sample in an ion source, delivering them into a vacuum region of a vacuum enclosure comprising an ion mobility analyser having an ion drift region formed between opposing electrodes defining an analytical gap. The ions emerge from the ion inlet as a supersonic jet of a buffer gas within which the ions are entrained to enter the drift region and, e.g., priorto mass spectral analysis of the ions in a downstream vacuum region, conducting differential ion mobility analysis of the ions in the first vacuum region. Priorto conducting differential ion mobility analysis (e.g., and mass spectral analysis) according of the ion, the method comprises a) changing a rate of flow of gas into or out of the vacuum region; b) measuring a gas pressure in the vacuum region and repeating steps a) and b) until a target gas pressure value is achieved; c) measuring a velocity of gas flow along the drift region and repeating steps a) to c) until the measured gas velocity value has achieved a pre-set target gas velocity value and subsequently conducting said differential ion mobility analysis and said mass spectral analysis according to said target gas pressure value and said target gas velocity value.

Classes IPC  ?

• G01N 27/624 - Spectrométrie de mobilité ionique différentielle [DMS]Spectrométrie de mobilité ionique à haut champ asymétrique [FAIMS]
• G01N 27/623 - Spectrométrie de mobilité ionique combinée à la spectrométrie de masse

Abrégé

An apparatus for nulling a magnetic field within a nulling region in an external ambient magnetic field comprising a plurality of separate magnetic field generating elements (102) are located at separate respective locations surrounding the nulling region for generating respective nulling magnetic fields extending into the nulling region. A plurality of magnetic field sensing elements (103) are positioned at a plurality of respective separate locations within the nulling region for sensing respective values of the magnetic field within the nulling region. A feedback control unit (150) controls the values of the respective nulling magnetic fields generated by each of the plurality of magnetic field generating elements in response to values of the magnetic field sensed by the plurality of magnetic field sensing elements by driving the magnetic field generating elements with respective electric currents that reduce the magnetic field values detected by respective magnetic field sensing elements to values not exceeding a pre-set threshold value corresponding to a pre-set nulling of the magnetic field within the nulling region.

Classes IPC  ?

• G01R 33/025 - Compensation de champs de dispersion

Abrégé

An apparatus for nulling a magnetic field within a nulling region in an external ambient magnetic field comprising a plurality of separate magnetic field generating elements (102) are located at separate respective locations surrounding the nulling region for generating respective nulling magnetic fields extending into the nulling region. A plurality of magnetic field sensing elements (103) are positioned at a plurality of respective separate locations within the nulling region for sensing respective values of the magnetic field within the nulling region. A feedback control unit (150) controls the values of the respective nulling magnetic fields generated by each of the plurality of magnetic field generating elements in response to values of the magnetic field sensed by the plurality of magnetic field sensing elements by driving the magnetic field generating elements with respective electric currents that reduce the magnetic field values detected by respective magnetic field sensing elements to values not exceeding a pre-set threshold value corresponding to a pre-set nulling of the magnetic field within the nulling region.

Classes IPC  ?

• G01R 33/025 - Compensation de champs de dispersion
• G01R 33/00 - Dispositions ou appareils pour la mesure des grandeurs magnétiques

Abrégé

Q12Q12Q1pp/e) of a protonating proton.

Classes IPC  ?

• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails

Abrégé

Qff00 Qii Qii (fiiCandCand )f00 (fiiCandCand )fQf00 Q̂ll l ]) if the score value matches or exceeds a threshold score value.

Classes IPC  ?

• H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails
• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

Abrégé

N NOPnn nN NM αnmnm TPmm TPmm m ) associated with that ion.

Classes IPC  ?

• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails
• H01J 49/38 - Omégatrons
• H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

Abrégé

A method of processing an image-charge/current signal representative of one or more ions undergoing oscillatory motion within an ion analyser apparatus. The method comprising obtaining a recording of the image-charge/current signal generated by the ion analyser apparatus in the time domain. By a signal processing unit, the method comprises determining a value for the period of a periodic signal component within the recorded signal. Then, the method includes truncating the recorded signal to provide a truncated signal having a duration substantially equal to an integer multiple of said period. A step of reconstructing a time-domain signal is done based on a selected one or more frequency-domain harmonic components of the truncated signal. Next, the method determines a magnitude of the reconstructed time-domain signal and therewith calculating a value representative of the charge of a said ion undergoing oscillatory motion within the ion analyser apparatus.

Classes IPC  ?

• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails

Abrégé

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.

Classes IPC  ?

• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• H01J 49/06 - Dispositifs électronoptiques ou ionoptiques

Abrégé

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.

Classes IPC  ?

• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• H01J 49/06 - Dispositifs électronoptiques ou ionoptiques

Abrégé

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.

Classes IPC  ?

• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• H01J 49/06 - Dispositifs électronoptiques ou ionoptiques

Abrégé

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.

Classes IPC  ?

• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• H01J 49/06 - Dispositifs électronoptiques ou ionoptiques

Abrégé

Control circuitry for stabilizing a DC voltage outputted by a DC power supply against changes in ambient temperature. The control circuitry includes: measurement circuitry configured to output a measurement voltage representative of a DC voltage outputted by a DC power supply; reference circuitry configured to output a reference voltage; and comparison circuitry configured to compare the measurement voltage with the reference voltage and, based on the comparison, output a control signal for controlling the DC voltage outputted by the DC power supply. At least one temperature-sensitive component of the control circuitry is located in an enclosure configured to maintain a substantially constant temperature within the enclosure.

Classes IPC  ?

• G05F 1/567 - Régulation de la tension ou de l'intensité là où la variable effectivement régulée par le dispositif de réglage final est du type continu utilisant des dispositifs à semi-conducteurs en série avec la charge comme dispositifs de réglage final sensible à une condition du système ou de sa charge en plus des moyens sensibles aux écarts de la sortie du système, p. ex. courant, tension, facteur de puissance pour compensation de température
• G05F 1/46 - Régulation de la tension ou de l'intensité là où la variable effectivement régulée par le dispositif de réglage final est du type continu
• H02M 1/32 - Moyens pour protéger les convertisseurs autrement que par mise hors circuit automatique

Abrégé

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.

Classes IPC  ?

• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
• H01J 49/06 - Dispositifs électronoptiques ou ionoptiques

Abrégé

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.

Classes IPC  ?

• H01J 49/06 - Dispositifs électronoptiques ou ionoptiques
• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

Abrégé

Charged particle energy analysers enabling simultaneous high transmission and energy resolution are described. The analysers have an electrode structure (11) comprising coaxial inner and outer electrodes (14, 15) having inner and outer electrode surfaces (IS, OS) respectively. The inner and outer electrode surfaces are defined, at least in part, by spheroidal surfaces having meridonal planes of symmetry orthogonal to a longitudinal axis of the electrode structure (11). The inner and outer electrode surfaces are generated by rotation, about the longitudinal axis, of arcs of two non- concentric circles having different radii R2 and R1 respectively, R2 being greater than R1. The distance of the outer electrode surface from the longitudinal axis in the respective meridonal plane is R01 and the distance of the inner electrode surface from the longitudinal axis in the respective plane is R02 and R1, R2, R01 and R02 have a defined relationship.

Classes IPC  ?

• H01J 49/48 - Spectromètres statiques utilisant des analyseurs électrostatiques, p. ex. secteur cylindrique, filtre de Wien
• H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

Abrégé

A mass spectrometer has a pulsed ion source, a first ion trap (10) for trapping ions generated by the pulsed ion source and for locating trapped ions for subsequent ejection from the first ion trap. A pulse of cooling gas is introduced into the first ion trap (10) at a peak pressure suitable for enabling the first ion trap (10) to trap ions. A turbomolecular pump (17) reduces the pressure of cooling gas before the trapped ions are ejected from the first ion trap (1) towards a second ion trap (20) for analysis. The pulsed ion source has a sample plate (14) which forms an end wall of the first ion trap (10).

Classes IPC  ?

• H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques
• H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

Abrégé

A method of introducing ions into an ion trap and an ion storage apparatus are described. Introduction means are used to introduce first ions into an ion trap through an entrance aperture to the ion trap. An operating condition of the introduction means is adjusted to cause second ions, of different polarity to the first ions to be introduced into the ion trap through the same entrance aperture.

Classes IPC  ?

• H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques
• H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons
• H01J 49/10 - Sources d'ionsCanons à ions

Abrégé

The present invention is concerned with methods for the selection of precursor ions of a sample polypeptide for fragmentation in mass spectrometry, together with methods for determining at least one putative amino acid sequence for a sample polypeptide, apparatus and computer programs for same.

Classes IPC  ?

• G06F 19/22 - pour la comparaison de séquences impliquant des nucléotides ou des acides aminés, p.ex. recherche d'homologie, identification de motifs ou de polymorphismes de nucléotides simples [SNP] ou alignement de séquences