Systems and methods are provided for the denoising of images in the presence of broadband noise based on the detection and/or estimation of in-band noise. According to various example embodiments, an estimate of broadband noise that lies within the imaging band is made by detecting or characterizing the out-of-band noise that lies outside of the imaging band. This estimated in-band noise may be employed for denoise the detected imaging waveform. According to other example embodiments, a reference receive circuit that is sensitive to noise within the imaging band, but is isolated from the imaging energy, may be employed to detect and/or characterize the noise within the imaging band. The estimated reference noise may be employed to denoise the detected in-band imaging waveform.
A system and method is provided for generating ultrasound at the tip of an intravascular catheter. This may be used for the treatment of vascular occlusions, including chronic total occlusions (CTOs) and thrombotic occlusions (e.g., deep vein thrombosis, stroke, myocardial infarction). For instance, the systems and methods may be used to induce cavitation to enhance the enzymatic degradation of a vascular occlusion. In some configurations, the approach employs a hollow cylindrical transducer, electrically stimulated in the radial direction at a frequency corresponding to the length mode excitation, thereby projecting ultrasound forwards past the catheter tip. This design overcomes electrical impedance issues for the generation of low frequencies with a smaller diameter transducer capable of negotiating a coronary artery. The hole within the transducer may accommodate a guidewire to facilitate its placement adjacent to the proximal portion of the occlusion.
A61B 17/22 - Instruments pour comprimer les ulcères ou similaires placés sur les organes internes du corpsInstruments pour curer les cavités des organes du corps, p. ex. des osInstruments, dispositifs ou procédés chirurgicaux pour l'élimination ou la destruction invasives des calculs utilisant des vibrations mécaniquesInstruments, dispositifs ou procédés chirurgicaux pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p. ex. en utilisant des cathéters
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A multi-axis lockable positioning system is disclosed that includes a plurality of rotational joints that are lockable in orientation via a single locking mechanism. In some example embodiments, the positioning system includes a proximal joint, an intermediate uniaxial joint and a distal joint, where the locking mechanism is configured to lock the intermediate uniaxial joint and to generate forces during actuation that are sufficient for locking the orientations of the proximal joint and the distal joint. The forces may be compression forces that are generated when locking two portions of the intermediate uniaxial joint together, such that the compression forces are communicated to the proximal joint through or within a first member extending between the proximal joint and the intermediate uniaxial joint, and communicated to the distal joint through or within a second member extending between the distal joint and the intermediate uniaxial joint.
A system for automatically predicting chemotherapy response in a patient with cancer using a trained machine learning model, the system including: a digital pathology imaging system for acquiring at least one pathology image; a patch-level processing module for capturing the local correlations within a tumor region in at least one pathology image patch, wherein the at least one pathology image patch is derived from at least one pathology image of a pre- treatment biopsy specimen, and extracting feature maps carrying relevant information of the at least one pathology image patch; a tumor-level processing module for aggregating the local information for each tumor region; a patient-level prediction module for applying the sequence of the local information for the tumor regions to derive global relations and predict the patient's response to chemotherapy.
G06V 10/70 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique
G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
G06V 10/40 - Extraction de caractéristiques d’images ou de vidéos
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
5.
COMPOSITIONS AND METHODS RELATED TO BLOOD-BRAIN BARRIER PENETRATION
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A construct is provided. The construct comprises poliovirus receptor and a Fc domain. In aspects, the PVR is a truncated PVR. Uses of the construct for reducing inflammatory diseases or conditions, reducing symptoms associated with inflammatory diseases or conditions, or reducing immune responses, and associated methods are also provided.
Described herein is a VISTA agonist for inhibiting an immune response, wherein the VISTA agonist causes at least one of the following: an increase in IL-10 expression; a decrease in proliferation of CD4+ T cells; a decrease in proliferation of CD8+ T cells; a decrease in IL-2 expression; a decrease in IFN-γ expression; and a decrease in IL-17 expression.
A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
8.
SYSTEMS AND METHODS FOR CHARACTERIZING INTRA-TUMOR REGIONS ON QUANTITATIVE ULTRASOUND PARAMETRIC IMAGES TO PREDICT CANCER RESPONSE TO CHEMOTHERAPY AT PRE-TREATMENT
A computer-implemented method for predicting tumor response to neoadjuvant chemotherapy, comprising: acquiring/generating, using an ultrasound device, ultrasound radiofrequency data and B-mode images from a tumor subject; identifying a region of interest, comprising a tumor, in each B-mode image; generating quantitative ultrasound (QUS) parametric map(s) by analysis of each RF frame associated with the B-mode images throughout the ROI to derive a corresponding QUS parameter; identifying distinct intra-tumor regions on the QUS parametric map(s) by applying a classification (clustering) algorithm to the QUS parametric map(s); extracting features from the intra-tumor regions on each of the QUS parametric map(s) to characterize the tumor; determining an optimal QUS biomarker for response prediction; training a classification algorithm for response prediction using the optimal QUS biomarker; and classifying the tumor subject into a responder or non-responder to NAC using the optimal QUS biomarker with the trained classification algorithm.
Ultrasound devices and systems are disclosed in which cooling of an active acoustic element of an ultrasound transducer is achieved via an electrically conductive member that extends beyond a proximal side of the active acoustic element to contact a heat exchanger. The electrically conductive member delivers electrical driving signals to the active acoustic element while conducting heat to the heat exchanger. A region of the proximal surface of the active acoustic element that is free from contact with the electrically conductive member may also absent from contact with a liquid or a solid, thereby facilitating reflection of ultrasound energy. The heat exchanger may include an electrically insulating fluid that contacts the electrically conductive member to remove the heat conducted through the electrically conductive member. The active acoustic element may be a multilayer lateral mode element, and the electrically conductive member may form an electrode of the lateral mode element.
F28F 3/06 - Éléments ou leurs ensembles avec moyens pour augmenter la surface de transfert de chaleur, p. ex. avec des ailettes, avec des évidements, avec des ondulations les moyens pouvant être fixés sur l'élément
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
B06B 1/06 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique fonctionnant par effet piézo-électrique ou par électrostriction
H01L 23/367 - Refroidissement facilité par la forme du dispositif
10.
SYSTEMS AND METHODS FOR IMAGE GUIDANCE AND DEVICE TRACKING DURING MAGNETIC RESONANCE IMAGING
Systems and methods are provided for tracking an interventional device during a magnetic resonance imaging procedure. A set of time-varying 3D non-Cartesian k- space trajectories are employed to collect an undersampled image dataset. The undersampled image dataset is processed to detect a local high-signal region having a known location on or within the interventional device, such as the location of a tracking coil, and employed to provide feedback for tracking a position of the device. At least some of the undersampled image dataset may be collected with a set of imaging coils and processed to generate an anatomical image. Image data from multiple datasets may be processed to generate a higher- resolution anatomical image, and may optionally be further processed to generate a visualization of the device, which may be combined with the anatomical image. The tracked position of the device may be employed to facilitate motion correction of the anatomical images.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
G01R 33/54 - Systèmes de traitement du signal, p. ex. utilisant des séquences d'impulsions
11.
SYSTEMS AND METHODS FOR CONTROLLING TRANSDUCER MODULES FOR GENERATING FOCUSED ULTRASOUND
A phased array ultrasound system includes one or more ultrasound array modules having respective array elements, each array element connected to a respective switch. Each array module receives a set of driving signals, each driving signal having a respective phase value, and the set of driving signals are provided to each switch. The switches are controlled such that the driving signal provided to a given array element has a phase value that is closest to an ideal phase value for focusing ultrasound energy at a selected focus location. At least two of the array modules each receive a unique module-specific set of driving signals having a respective unique set of phases. A given unique set of phases values may be determined based on a set of ideal phases for focusing ultrasound energy at one or more locations, such as a selected focal location or a selected focal region.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
B06B 1/02 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique
12.
T CELLS COMPRISING AN UNREARRANGED T CELL RECEPTOR (TCR) GENE LOCUS AND METHODS OF USE THEREOF
A method of generating stem cells that are unable to undergo T cell receptor (TCR) or B cell receptor (BCR) gene rearrangements is provided. In particular, methods, compositions and kits for use in generating cells of the T cell lineage or B cell lineage comprising an unrearranged TCR gene locus or BCR gene locus, respectively, are 5 provided. In one embodiment, the cells are further engineered to express a TCR, bCR or CAR conferring specificity to an antigen of interest. Cells, compositions, kits and uses thereof are also provided.
Systems and methods are disclosed that employ an indirect exclusionary approach to the identification of abnormal tissue regions based on the processing of a plurality of multimodal and/or multiparametric image datasets having respective parameters defining a parameter space. A region of parameter space associated with normal tissue, optionally determined in a subject-specific manner, is employed to facilitate the indirect detection and identification of voxels and/or regions associated with abnormal tissue. In some example embodiments, additional parameter space criteria may be employed to further limit the voxels associated with abnormal tissue. A physical space image showing locations of abnormal tissue voxels, or segmented regions associated therewith, may be presented and optionally dynamically updated as additional parameter space criteria is varied in response to user input. Abnormal tissue voxels may be detected locally or throughout an organ. Segmented regions may be employed for the training of a machine learning algorithm.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
14.
ULTRASOUND TRANSDUCER AND METHOD FOR MAKING THE SAME
The present application provides a multilayer lateral mode coupling method for phased array construction and transducer devices built accordingly. This disclosure describes and demonstrates that the electrical impedance of a phased array can be substantially reduced and readily controlled to be close to the source impedance. The fabrication process is relatively simple and inexpensive. In addition, the elements are robust for use in 1.5, 2, 3 or other dimensional configurations, over an extended period of operation, without structural failure, and providing a high power output required for imaging and/or medical therapy applications.
B06B 1/06 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique fonctionnant par effet piézo-électrique ou par électrostriction
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
nn, wherein n is greater than 0. The reaction product can be combined with a thiolated biomolecule. Matrices formed from the PEG prepolymer and the thiolated biomolecule are provided and uses thereof.
A61K 47/65 - Séquences de liaison, liants ou bras-espaceurs peptidiques, p. ex. séquences de liaison peptidiques vulnérable aux protéases
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
C08G 81/00 - Composés macromoléculaires obtenus par l'interréaction de polymères en l'absence de monomères, p. ex. polymères séquencés
16.
SYSTEM FOR AUTOMATED AND QUANTITATIVE ASSESSMENT OF METASTATIC SPINAL STABILITY
Computational tools for automated and quantitative assessment of metastatic spinal stability. Computational image analysis methods, that may include deep learning are used to automatically quantify spinal geometry/quality and disease burden from medical images (CT and MR) that can be used to predict patient outcomes of vertebral stability / risk of fracture. Two tools are provided: 1) An interpretable enhanced automated SINS (spinal instability neoplastic scoring) tool which calculates improved quantitative individual image-based parameters used in SINS and calculates stability through a similar scoring system; 2) A tool that directly estimates vertebral stability/fracture risk based on 3D imaging (with or without non-imaging patient specific clinical data). The automated tools may be used to improve clinical workflows (through automation) and accuracy, sensitivity, and specificity of vertebral stability prediction that can aid clinicians in better directing treatment to optimize patient outcomes. The tools are particularly useful in patients undergoing planning for stereotactic body radiation therapy (SBRT) because of the accessibility of clinical imaging and the high likelihood (14%) of vertebral compression fracture (VCF) and associated mechanical instability following this procedure.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
17.
AGENT FOR PROMOTING ANGIOGENESIS AND METHODS AND USES THEREOF
The present disclosure relates to compounds of Formula (I) which are multimeric forms of a monomeric binding peptide linearly bonded to PEG moieties to form the multimers. The multimeric forms stimulate angiogenesis and promote wound healing. The disclosure also includes pharmaceutical compositions comprising the multimers, including compositions suitable for topical or systemic administration.
A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
A61K 31/215 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques
A61K 31/351 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle non condensés avec un autre cycle
A61K 31/7056 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à cinq chaînons avec l'azote comme hétéro-atome d'un cycle
A61K 38/18 - Facteurs de croissanceRégulateurs de croissance
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p. ex. PEG, PPG, PEO ou polyglycérol
A61P 31/16 - Antiviraux pour le traitement des virus ARN de la grippe ou des rhinovirus
18.
SYSTEMS AND METHODS FOR PERFORMING TRANSCRANIAL ULTRASOUND THERAPEUTIC AND IMAGING PROCEDURES
Systems and methods are provided for performing transcranial diagnostic procedures using a transcranial ultrasound transducer array. The array elements are positioned and oriented such that far field regions respectively associated therewith spatially overlap within the brain of a patient. The array elements may be oriented approximately normal to the skull, permitting efficient coupling of ultrasound energy into the brain. The array elements are controlled to generate ultrasound pulses, where the timing of the pulses is controlled, based on registration between the array elements and volumetric image data, such that ultrasound energy is focused at a target within spatially overlapping far fields of the array elements. The transcranial ultrasound transducer array elements may be positioned and oriented relative to the skull such that their respective ultrasound beams are focused within the skull and diverging with the brain.
A minimally invasive method for the reduction of hypertension is provided using focused ultrasound. After injection of ultrasound-responsive nanodroplets loaded with a therapeutic agent (e.g. barbiturates), focused ultrasound is delivered to a norepinephrine-producing region, such as the periaqueductal gray region, thereby locally releasing the therapeutic agent payload from the nanodroplets and achieving a therapeutic reduction in blood pressure. Acoustic emissions from vaporizing droplets may be employed, for example, to infer one or more therapeutic parameters based on a pre-established correlation. For example, plasma hormone content and/or the change in blood pressure may be inferred, thereby providing a means of real-time treatment monitoring. The present example methods may be employed to achieve a reduction in blood pressure for subjects exhibiting drug-resistant hypertension.
A61J 3/00 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration
20.
PATIENT-SPECIFIC HEADSET FOR DIAGNOSTIC AND THERAPEUTIC TRANSCRANIAL PROCEDURES
Systems, methods and devices are provided for performing diagnostic or therapeutic transcranial procedures using a patient-specific transcranial headset. The patient-specific headset may include a patient-specific frame that is fabricated, according to volumetric image data, to conform to an anatomical curvature of a portion of a patient's head. The patient-specific frame is configured to support a plurality of transducers in pre-selected positions and orientations, which may be spatially registered to the volumetric image data. This spatial registration may be employed to control at least a portion of the transducers to focus energy at a preselected tissue region.
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
A61B 90/14 - Fixateurs pour parties du corps, p. ex. clamps crâniensDétails de construction des fixateurs, p. ex. broches
The present application relates to a dye compound of the formula (I), or a salt thereof. The present application relates to the use of the fluorescent dye or salt for various applications, such as for staining cells and for assessing the effect of an agent on a cell phenotypic state.
Described herein is a bispecific scFv construct agonizing both CD3 and CD28 pathways. Typically, the construct is soluble and activates, expands, and differentiates human T cells ex vivo. Related compositions and methods are also described, such as methods for expanding, activating, and or differentiating T cells ex vivo and methods of treating cancer.
Stain deconvolution methods and systems are disclosed employing a deep-image- prior-based neural network structure and associated training protocol. Example stain deconvolution networks employ auto-encoder networks to generate stain concentration maps for a plurality of stains associated with a colour target image, without requiring training based on a large reference image dataset. The stain deconvolution network is trained using a loss function that promotes correct image generation and the separation between the stain concentration maps generated by the auto-encoder networks. The deep-image-prior-based stain deconvolution networks may be configured to encode an adapted physics model that includes a set of parameters that model background illumination and the nonlinear dependence of absorption on concentration and wavelength. The present example methods of stain deconvolution, which may be performed in the absence of previous training data, are thus generalizable to accommodate multiple stains and previously uncharacterized stain types and can be extended to perform stain normalization.
ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (Canada)
Inventeur(s)
Andrews, David
Kale, Justin
Pogmore, Justin
Al-Awar, Rima
Isaac, Methvin
Poda, Gennady
Uehling, David
Xin, Tao
Abrégé
The present application relates to isoquinoline compounds of Formula (I), to processes for their preparation and to compositions comprising them. More particularly, the present application relates to compound of Formula (I) that have activity as inhibitors of Bcl2- associated X protein (BAX) and/or Bcl-2 antagonist killer (BAK), and to their use in the treatment of diseases, disorders or conditions treatable by inhibiting BAX and/or BAK such as neurodegenerative diseases, disorders or conditions.
C07D 217/22 - Composés hétérocycliques contenant les systèmes cycliques de l'isoquinoléine ou de l'isoquinoléine hydrogénée avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du cycle contenant l'azote
A61K 31/472 - Isoquinoléines non condensées, p. ex. papavérine
A61K 31/4725 - Isoquinoléines non condensées, p. ex. papavérine contenant d'autres hétérocycles
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
25.
ELECTROCHEMICAL IMMUNO-BIOSENSOR AND METHOD FOR DETECTION OF CIRCULATING PROTEIN BIOMARKERS
The present disclosure provides a biosensor platform for rapid detection of otolin-1 and prestin, blood-circulating proteins specifically expressed in the vestibule and cochlea, respectively. The platform is designed on a DNA-based immunoassay that employs conjugated antibodies for target protein recognition, which when bound, altered the DNA-DNA hybridization on the surface, resulting in generation of a concentration-dependent electrochemical output in whole blood. Signal amplification is acquired by employing high-curvature nanostruc-tured electrodes for sensitive sample analysis at low picomolar concentrations with a three-fold quantitative range, in a 10-µL sample in 10 minutes. Using an-tibodies as recognition elements allows for the adaptation of this platform to de-tect any blood-circulating protein.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
26.
System and method for controlling focused ultrasound treatment
A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
Thus, the present disclosure provides a kit for collection of biofluids and preservation of any DNA and/or RNA contained in said biofluid. The kit includes a wipe composed of fibers for absorbing a preselected biofluid, the wipe being impregnated with one or more skin-friendly chemicals for preservation of the biofluid absorbed into the wipe. The kit includes a rigid re-sealable tube configured to contain the impregnated wipe therein, a re-sealable bag for sealing the rigid re-sealable tube containing the impregnated wipe for transportation. The kit includes instructions on how to impregnate the wipe with the pre-selected biofluid and seal it in the re-sealable bag, and a return envelope configured to receive therein the re-sealable bag containing the impregnated wipe.
A system for predicting breast cancer response to neo-adjuvant chemotherapy (NAC) using quantitative ultrasound (QUS) parametric images and/or B-mode images, the system comprising: an imaging system for acquiring at least one ultrasound data frame comprising a raw RF signal, and/or an image; with a computer system performing the operations of: receiving the at least one ultrasound data frame and using one or more predefined rules to identify a region of interest (ROI) in each of the at least one ultrasound data frame; generating at least one quantitative ultrasound (QUS) parametric map and/or processed B-mode image for the tumor; with a feature network of a machine learning architecture, extracting optimal feature maps from the QUS parametric images and/or B-mode images; and classifying the tumor subject into a responder or a non-responder to the NAC.
In at least some examples, a method of treating an eye, includes (i) imaging a patient's vitreous using a probe, (ii) defining a window on a desired region of the vitreous, (iii) administering ultrasonic energy treatment to the desired region within the window, (iv) continually monitoring the treatment via the probe, (v) adjusting a characteristic of the ultrasonic energy treatment based on the monitoring, (vi) re-imaging the desired region of the vitreous after the treatment is administered, and (vii) evaluating or observing the desired region to determine whether a target percentage of a vitreous opacity has been resolved.
Systems are provided that employ dynamic modeling of heartbeats to process electroencephalography (EEG) signals for the suppression of BCG artifacts. The system may be configured to generate an instantaneous EEG correction for ballistocardiogram (BCG) artifact subtraction, the correction being modeled for a selected latency within a selected cardiac cycle. Cardiac cycles with similar EKG signals at the selected latency to that of the selected cardiac cycle are identified and the EEG signals from these similar cardiac cycles, at the selected latency, are employed to generate a modeled EEG signal that represents the instantaneous contribution from the BCG artifact. Accordingly, the system models BCG artifacts by pooling EEG signals at time instants with similar cardiac dynamics. The resulting modeled EEG signal is taken as the estimated BCG artifact and subtracted from the measured EEG signals to generate artifact-suppressed EEG signals.
Systems are provided that employ dynamic modeling of heartbeats to process electroencephalography (EEG) signals for the suppression of BCG artifacts. The system may be configured to generate an instantaneous EEG correction for ballistocardiogram (BCG) artifact subtraction, the correction being modeled for a selected latency within a selected cardiac cycle. Cardiac cycles with similar EKG signals at the selected latency to that of the selected cardiac cycle are identified and the EEG signals from these similar cardiac cycles, at the selected latency, are employed to generate a modeled EEG signal that represents the instantaneous contribution from the BCG artifact. Accordingly, the system models BCG artifacts by pooling EEG signals at time instants with similar cardiac dynamics. The resulting modeled EEG signal is taken as the estimated BCG artifact and subtracted from the measured EEG signals to generate artifact- suppressed EEG signals.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
Systems and methods are provided for the denoising of images in the presence of broadband noise based on the detection and/or estimation of in-band noise. According to various example embodiments, an estimate of broadband noise that lies within the imaging band is made by detecting or characterizing the out-of-band noise that lies outside of the imaging band. This estimated in-band noise may be employed for denoise the detected imaging waveform. According to other example embodiments, a reference receive circuit that is sensitive to noise within the imaging band, but is isolated from the imaging energy, may be employed to detect and/or characterize the noise within the imaging band. The estimated reference noise may be employed to denoise the detected in-band imaging waveform.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
Described herein is a VISTA agonist for inhibiting an immune response, wherein the VISTA agonist causes at least one of the following: an increase in IL-10 expression; a decrease in proliferation of CD4+ T cells; a decrease in proliferation of CD8+ T cells; a decrease in IL-2 expression; a decrease in IFN-? expression; and a decrease in IL-17 expression.
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
Described herein is a VISTA agonist for inhibiting an immune response, wherein the VISTA agonist causes at least one of the following: an increase in IL-10 expression; a decrease in proliferation of CD4+ T cells; a decrease in proliferation of CD8+ T cells; a decrease in IL-2 expression; a decrease in IFN-γ expression; and a decrease in IL-17 expression.
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
SYSTEMS AND METHODS FOR CHARACTERIZING INTRA-TUMOR REGIONS ON QUANTITATIVE ULTRASOUND PARAMETRIC IMAGES TO PREDICT CANCER RESPONSE TO CHEMOTHERAPY AT PRE-TREATMENT
A computer-implemented method for predicting tumor response to neoadjuvant chemotherapy, comprising: acquiring/generating, using an ultrasound device, ultrasound radiofrequency data and B-mode images from a tumor subject; identifying a region of interest, comprising a tumor, in each B-mode image; generating quantitative ultrasound (QUS) parametric map(s) by analysis of each RF frame associated with the B-mode images throughout the ROI to derive a corresponding QUS parameter; identifying distinct intra-tumor regions on the QUS parametric map(s) by applying a classification (clustering) algorithm to the QUS parametric map(s); extracting features from the intra-tumor regions on each of the QUS parametric map(s) to characterize the tumor; determining an optimal QUS biomarker for response prediction; training a classification algorithm for response prediction using the optimal QUS biomarker; and classifying the tumor subject into a responder or non-responder to NAC using the optimal QUS biomarker with the trained classification algorithm.
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
G06V 10/48 - Extraction de caractéristiques d’images ou de vidéos en cartographiant les valeurs caractéristiques du motif en espace paramétrique, p. ex. transformation de Hough
G06V 10/762 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant le regroupement, p. ex. de visages similaires sur les réseaux sociaux
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
37.
SYSTEMS AND METHODS FOR CHARACTERIZING INTRA-TUMOR REGIONS ON QUANTITATIVE ULTRASOUND PARAMETRIC IMAGES TO PREDICT CANCER RESPONSE TO CHEMOTHERAPY AT PRE-TREATMENT
A computer-implemented method for predicting tumor response to neoadjuvant chemotherapy, comprising: acquiring/generating, using an ultrasound device, ultrasound radiofrequency data and B-mode images from a tumor subject; identifying a region of interest, comprising a tumor, in each B-mode image; generating quantitative ultrasound (QUS) parametric map(s) by analysis of each RF frame associated with the B-mode images throughout the ROI to derive a corresponding QUS parameter; identifying distinct intra-tumor regions on the QUS parametric map(s) by applying a classification (clustering) algorithm to the QUS parametric map(s); extracting features from the intra-tumor regions on each of the QUS parametric map(s) to characterize the tumor; determining an optimal QUS biomarker for response prediction; training a classification algorithm for response prediction using the optimal QUS biomarker; and classifying the tumor subject into a responder or non-responder to NAC using the optimal QUS biomarker with the trained classification algorithm.
G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
G06V 10/48 - Extraction de caractéristiques d’images ou de vidéos en cartographiant les valeurs caractéristiques du motif en espace paramétrique, p. ex. transformation de Hough
G06V 10/762 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant le regroupement, p. ex. de visages similaires sur les réseaux sociaux
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
38.
METHOD AND COMPOSITIONS FOR NEURONAL REPROGRAMMING
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Canada)
Inventeur(s)
Schuurmans, Carol
Mclaurin, Joanne
Morshead, Cindy
Park, Eunjee
Kehtari, Tarlan
Vasan, Lakshmy
Faiz, Maryam
Enbar, Tom
Abrégé
The present application provides a mutant basic?helix?loop?helix (bHLH) transcription factor that comprises a mutation of one or more phosphoacceptor site for proline?directed serine?threonine kinases alone or together with a mutation in a conserved PKA site in the HLH domain, found in the corresponding wild?type bHLH transcription factor, and exhibits reduced phosphorylation by proline?directed serine?threonine kinases and PKA. Also provided are nucleic acids encoding the mutant bHLH transcription factor, and vectors comprising the encoding nucleic acids. Use of the mutant bHLH transcription factor or nucleic acid encoding the mutant bHLH transcription factor for therapeutic purposes can efficiently induce neuronal lineage conversion of glial cells, even in an inhibitory environment, and are useful in preventing or treating neurodegenerative diseases and disorders, and for treating CNS injuries. Further provided a use a ZBTB18 transcription factor or a nucleic acid encoding the ZBTB18 transcription factor for neuronal lineage conversion of glial cells.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
39.
METHOD AND COMPOSITIONS FOR NEURONAL REPROGRAMMING
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Canada)
Inventeur(s)
Schuurmans, Carol
Mclaurin, Joanne
Morshead, Cindy
Park, Eunjee
Kehtari, Tarlan
Vasan, Lakshmy
Faiz, Maryam
Enbar, Tom
Abrégé
The present application provides a mutant basic‐helix‐loop‐helix (bHLH) transcription factor that comprises a mutation of one or more phosphoacceptor site for proline‐directed serine‐threonine kinases alone or together with a mutation in a conserved PKA site in the HLH domain, found in the corresponding wild‐type bHLH transcription factor, and exhibits reduced phosphorylation by proline‐directed serine‐threonine kinases and PKA. Also provided are nucleic acids encoding the mutant bHLH transcription factor, and vectors comprising the encoding nucleic acids. Use of the mutant bHLH transcription factor or nucleic acid encoding the mutant bHLH transcription factor for therapeutic purposes can efficiently induce neuronal lineage conversion of glial cells, even in an inhibitory environment, and are useful in preventing or treating neurodegenerative diseases and disorders, and for treating CNS injuries. Further provided a use a ZBTB18 transcription factor or a nucleic acid encoding the ZBTB18 transcription factor for neuronal lineage conversion of glial cells.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C12N 15/12 - Gènes codant pour des protéines animales
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
A method of generating stem cells that are unable to undergo T cell receptor (TCR) or B cell receptor (BCR) gene rearrangements is provided. In particular, methods, compositions and kits for use in generating cells of the T cell lineage or B cell lineage comprising an unrearranged TCR gene locus or BCR gene locus, respectively, are 5 provided. In one embodiment, the cells are further engineered to express a TCR, bCR or CAR conferring specificity to an antigen of interest. Cells, compositions, kits and uses thereof are also provided.
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
A method of generating stem cells that are unable to undergo T cell receptor (TCR) or B cell receptor (BCR) gene rearrangements is provided. In particular, methods, compositions and kits for use in generating cells of the T cell lineage or B cell lineage comprising an unrearranged TCR gene locus or BCR gene locus, respectively, are 5 provided. In one embodiment, the cells are further engineered to express a TCR, bCR or CAR conferring specificity to an antigen of interest. Cells, compositions, kits and uses thereof are also provided.
C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
Described here are systems and methods for positioning a surgical implant, such as a glenoid component, or other medical device intra-operatively. In general, the systems and methods described in the present disclosure implement a computer vision system, which may be a structured light computer vision system, together with a suitable optical tracker as an accurate intra-operative tool for predicting post-operative implant position in surgical procedures.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61F 2/46 - Outils particuliers pour l'implantation des articulations artificielles
A61B 17/17 - Dispositifs de guidage pour les forets
The present disclosure provides for an imaging probe with a rotatable core which allows for rotating imaging assembly that is larger in diameter than the lumen in which the rotatable core resides, as well as methods to construct said probes. The imaging probes are generally elongate flexible imaging catheters for use in cardiovascular procedures. The ability to have a smaller lumen to hold the rotatable core simplifies the inclusion of other functional components to the catheter and may improve the quality of the images produced.
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p. ex. en utilisant des cathéters
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 18/22 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p. ex. d'une fibre optiquePièces à main à cet effet
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
44.
SYSTEMS AND METHODS FOR REDUCING THERMAL SKULL-INDUCED ABERRATIONS DURING TRANSCRANIAL ULTRASOUND THERAPEUTIC PROCEDURES
Various example embodiments of the present disclosure provide systems and methods for the dynamic correction and reduction of thermal variations in skull-induced aberrations during a focused ultrasound therapy procedure. Unlike conventional approaches involving static corrections for skull-induced aberrations, various example embodiments of the present disclosure employ ultrasound detection and a skull thickness estimate from volumetric image data to intermittently and dynamically determine corrections for skull-induced aberrations, such that aberration correction reduction is updated intraoperatively and maintained despite local thermally-induced changes in the speed of sound of the local skull region due to intraoperative intracranial heating. Furthermore, in some example embodiments, a measure dependent on the speed of sound with the skull is intraoperatively determined and compared to a previously determined value of the measure to determine a change in the skull temperature, based on a pre-determined relationship between changes in the measure and changes in skull temperature.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A system and method for widening a narrowed blood vessel in a patient, the system including a guidewire, a balloon catheter having an enlarging balloon, and a tubular support sleeve having at least one support balloon. The support balloon is inflated to mechanically support the advancement of the balloon catheter into a narrowed segment of the blood vessel.
The present disclosure provides a deep orbital access retractor (DOAR) device which includes a manipulable body section including a compressible handle having a size and shape to be manipulated by at least two (2) digits of a clinician. A flexible head section having two (2) arms with each arm having a distal end and a proximal end, with the distal ends of the arms spaced apart forming a gap there-between at a distal tip section. A flexible flange material envelops and encloses the two arms and the gap and extends around a periphery of the flexible head section. A flexible diaphragm is attached to and extends between the two arms to provide a generally spoon-shaped flexible head section. The flexible head section is linked to the compressible handle section with the linkage being configured such that upon compression of the handle section the arms articulate with respect to each other thereby causing narrowing of the flexible head section to allow for insertion into the orbit and positioning between soft tissue and bone while the flexible diaphragm remains in sufficient tension to not obstruct the view of the operator into the orbit. When compression is released the flexible diaphragm develops sufficient tension and rigidity for applying sufficient force to retract the orbital contents of a patient to allow access to orbital walls.
Described herein are systems, devices and methods that enable dynamic modification of the physicochemical properties of a hydrogel during its in vivo formation and delivery by a catheter. In some example embodiments, an extended endoluminal hydrogel delivery device is employed for delivering a hydrogel within given body cavity, such as within the lumen of a blood vessels. In some example embodiments, a hydrogel precursor, as a non-viscous liquid, is injected through an intravascular catheter and crosslinking of the hydrogel precursor is initiated within a distal region of the catheter. The crosslinking process is controlled, by a control means associated with a distal region of the catheter, to control or modify one or more properties of the hydrogel. The properties may be controlled such that a hydrogel is suitable to embolize the specific target or deliver drugs or other materials beneficial to the site.
A61B 18/24 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p. ex. d'une fibre optiquePièces à main à cet effet avec un cathéter
Described herein is a bispecific scFv construct agonizing both CD3 and CD28 pathways. Typically, the construct is soluble and activates, expands, and differentiates human T cells ex vivo. Related compositions and methods are also described, such as methods for expanding, activating, and or differentiating T cells ex vivo and methods of treating cancer.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
Described herein is a bispecific scFv construct agonizing both CD3 and CD28 pathways. Typically, the construct is soluble and activates, expands, and differentiates human T cells ex vivo. Related compositions and methods are also described, such as methods for expanding, activating, and or differentiating T cells ex vivo and methods of treating cancer.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Canada)
Inventeur(s)
Mandelis, Andreas
Choi, Sung Soo
Lashkari, Bahman
Courtney, Brian
Foster, Stuart
Abrégé
Systems and methods are disclosed that facilitate the reduction of both radio frequency (RF) noise and photoacoustic artefacts in differential photoacoustic radar imaging through a multi-step electrical and optical domain calibration method. An example two-step calibration method involves reducing RF image noise via an initial calibration step that involves the control of the relative amplitudes and phases of electrical driving modulation waveforms, while a second calibration step involves the differential suppression of photoacoustic artefact signals via tuning, in the optical domain, of the relative intensity the optical beams that are delivered to the sample. Another example embodiment involves the use of the standard deviation of the unwrapped phase that is obtained, after performing frequency-domain cross-correlation and an inverse transform to the time domain, to improve the amplitude signal that is employed to generate a differential photoacoustic radar image.
In at least some examples, a method of treating an eye, includes (i) imaging a patient's vitreous using a probe, (ii) defining a window on a desired region of the vitreous, (iii) administering ultrasonic energy treatment to the desired region within the window, (iv) continually monitoring the treatment via the probe, (v) adjusting a characteristic of the ultrasonic energy treatment based on the monitoring, (vi) re-imaging the desired region of the vitreous after the treatment is administered, and (vii) evaluating or observing the desired region to determine whether a target percentage of a vitreous opacity has been resolved.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
Systems and methods are provided for assessing nasal deviation and symmetry via the processing of facial surface data. Facial surface data may be processed to determine a nasal deviation measure indicative of a lateral deviation between a nasal midline and a facial midplane. The facial surface data may also be processed to determine a measure of nasal symmetry associated with a selected nasal surface region, such as an aesthetic subunit. Nasal deviation and symmetry information based on both measures may then be presented. In some example implementations, a single nasal symmetry measure is generated and present for a given nasal surface region. Reference surface data characterizing a reference symmetrical facial shape and having a defined facial direction relative to a coordinate system may be employed to align the facial surface data prior to the determination of the nasal deviation and nasal symmetry measures.
G06T 7/68 - Analyse des attributs géométriques de la symétrie
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/103 - Dispositifs de mesure pour le contrôle de la forme, du dessin, de la dimension ou du mouvement du corps ou de parties de celui-ci, à des fins de diagnostic
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
G06T 7/33 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images utilisant des procédés basés sur les caractéristiques
53.
SYSTEMS AND METHODS FOR ASSESSMENT OF NASAL DEVIATION AND ASYMMETRY
Systems and methods are provided for assessing nasal deviation and symmetry via the processing of facial surface data. Facial surface data may be processed to determine a nasal deviation measure indicative of a lateral deviation between a nasal midline and a facial midplane. The facial surface data may also be processed to determine a measure of nasal symmetry associated with a selected nasal surface region, such as an aesthetic subunit. Nasal deviation and symmetry information based on both measures may then be presented. In some example implementations, a single nasal symmetry measure is generated and present for a given nasal surface region. Reference surface data characterizing a reference symmetrical facial shape and having a defined facial direction relative to a coordinate system may be employed to align the facial surface data prior to the determination of the nasal deviation and nasal symmetry measures.
An apparatus for slicing a cartilage sample includes a rear cartilage support cup, a cartilage clamp, a front cartilage support, a cartilage receiving region, and a cartilage cutting element. The cartilage clamp has first and second clamp members spaced apart from and aligned in a clamping direction transverse to a longitudinal axis. The cartilage receiving region is bounded by the first and second clamp members, the front cartilage support, and the rear cartilage support cup. The cartilage cutting element is spaced rearwardly from the front cartilage support by a cartilage slice thickness, the cartilage cutting element being movable across the cartilage receiving region in a cutting direction transverse to the longitudinal axis.
The present disclosure provides a biosensor platform for rapid detection of otolin-1 and prestin, blood-circulating proteins specifically expressed in the vestibule and cochlea, respectively. The platform is designed on a DNA-based immunoassay that employs conjugated antibodies for target protein recognition, which when bound, altered the DNA-DNA hybridization on the surface, resulting in generation of a concentration-dependent electrochemical output in whole blood. Signal amplification is acquired by employing high-curvature nanostruc-tured electrodes for sensitive sample analysis at low picomolar concentrations with a three-fold quantitative range, in a 10-µL sample in 10 minutes. Using an-tibodies as recognition elements allows for the adaptation of this platform to de-tect any blood-circulating protein.
The present disclosure provides a biosensor platform for rapid detection of otolin-1 and prestin, blood-circulating proteins specifically expressed in the vestibule and cochlea, respectively. The platform is designed on a DNA-based immunoassay that employs conjugated antibodies for target protein recognition, which when bound, altered the DNA-DNA hybridization on the surface, resulting in generation of a concentration-dependent electrochemical output in whole blood. Signal amplification is acquired by employing high-curvature nanostruc-tured electrodes for sensitive sample analysis at low picomolar concentrations with a three-fold quantitative range, in a 10-µL sample in 10 minutes. Using an-tibodies as recognition elements allows for the adaptation of this platform to de-tect any blood-circulating protein.
Described herein is an egg yolk extract comprising freed/lysed yolk granules and/or yolk spheres. Also described is an egg yolk extract comprising the liquid contents of a shelled egg, wherein the liquid contents comprise yolk granules. Also described are an egg yolk extract comprising the liquid contents of yolk spheres; an egg yolk extract comprising the liquid contents of yolk granules; an egg yolk extract comprising ovalbumin and other anti-bactericidal proteins in egg white; and an egg yolk extract that supports cell proliferation at least equivalent to FBS when used at the same concentration in a cell culture medium. Related supplements, media, and methods are also described.
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
C07K 14/465 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant d'oiseaux
Described herein is an egg yolk extract comprising freed/lysed yolk granules and/or yolk spheres. Also described is an egg yolk extract comprising the liquid contents of a shelled egg, wherein the liquid contents comprise yolk granules. Also described are an egg yolk extract comprising the liquid contents of yolk spheres; an egg yolk extract comprising the liquid contents of yolk granules; an egg yolk extract comprising ovalbumin and other anti-bactericidal proteins in egg white; and an egg yolk extract that supports cell proliferation at least equivalent to FBS when used at the same concentration in a cell culture medium. Related supplements, media, and methods are also described.
C12N 5/02 - Propagation de cellules individuelles ou de cellules en suspensionLeur conservationMilieux de culture à cet effet
C07K 14/465 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant d'oiseaux
Thus, the present disclosure provides a kit for collection of biofluids and preservation of any DNA and/or RNA contained in said biofluid. The kit includes a wipe composed of fibers for absorbing a preselected biofluid, the wipe being impregnated with one or more skin-friendly chemicals for preservation of the biofluid absorbed into the wipe. The kit includes a rigid re-sealable tube configured to contain the impregnated wipe therein, a re-sealable bag for sealing the rigid re-sealable tube containing the impregnated wipe for transportation. The kit includes instructions on how to impregnate the wipe with the pre-selected biofluid and seal it in the re-sealable bag, and a return envelope configured to receive therein the re-sealable bag containing the impregnated wipe.
Thus, the present disclosure provides a kit for collection of biofluids and preservation of any DNA and/or RNA contained in said biofluid. The kit includes a wipe composed of fibers for absorbing a preselected biofluid, the wipe being impregnated with one or more skin-friendly chemicals for preservation of the biofluid absorbed into the wipe. The kit includes a rigid re-sealable tube configured to contain the impregnated wipe therein, a re-sealable bag for sealing the rigid re-sealable tube containing the impregnated wipe for transportation. The kit includes instructions on how to impregnate the wipe with the pre-selected biofluid and seal it in the re-sealable bag, and a return envelope configured to receive therein the re-sealable bag containing the impregnated wipe.
Systems and methods are provided for performing transcranial diagnostic procedures using a transcranial ultrasound transducer array. The array elements are positioned and oriented such that far field regions respectively associated therewith spatially overlap within the brain of a patient. The array elements may be oriented approximately normal to the skull, permitting efficient coupling of ultrasound energy into the brain. The array elements are controlled to generate ultrasound pulses, where the timing of the pulses is controlled, based on registration between the array elements and volumetric image data, such that ultrasound energy is focused at a target within spatially overlapping far fields of the array elements. The transcranial ultrasound transducer array elements may be positioned and oriented relative to the skull such that their respective ultrasound beams are focused within the skull and diverging with the brain.
Intravascular imaging catheters are provided that include a distal sheath portion having a lumen that is configured to optionally receive a guidewire or an imaging assembly. The distal sheath portion may be configured to have dimensions such that when a guidewire is inserted through the lumen and extends through a distal exit port, the distal sheath portion may be employed as a microcatheter. External tissue may be imaged at a location at or near the distal end of the catheter, enabling, for example, the controlled imaging of a total occlusion, and the positioning of the distal end (and guidewire) within a true lumen associated with a total occlusion. A structural stop may be provided at or near the distal end of the distal sheath portion to prohibit extension of the imaging assembly out of the distal exit port, while permitting the extension of the guidewire through the distal exit port.
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p. ex. en utilisant des cathéters
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
63.
Systems and methods for noise reduction in imaging
Systems and methods are provided for the denoising of images in the presence of broadband noise based on the detection and/or estimation of in-band noise. According to various example embodiments, an estimate of broadband noise that lies within the imaging band is made by detecting or characterizing the out-of-band noise that lies outside of the imaging band. This estimated in-band noise may be employed for denoise the detected imaging waveform. According to other example embodiments, a reference receive circuit that is sensitive to noise within the imaging band, but is isolated from the imaging energy, may be employed to detect and/or characterize the noise within the imaging band. The estimated reference noise may be employed to denoise the detected in-band imaging waveform.
Ultrasound devices and systems are disclosed in which cooling of an active acoustic element of an ultrasound transducer is achieved via an electrically conductive member that extends beyond a proximal side of the active acoustic element to contact a heat exchanger. The electrically conductive member delivers electrical driving signals to the active acoustic element while conducting heat to the heat exchanger. A region of the proximal surface of the active acoustic element that is free from contact with the electrically conductive member may also absent from contact with a liquid or a solid, thereby facilitating reflection of ultrasound energy. The heat exchanger may include an electrically insulating fluid that contacts the electrically conductive member to remove the heat conducted through the electrically conductive member. The active acoustic element may be a multilayer lateral mode element, and the electrically conductive member may form an electrode of the lateral mode element.
F28F 3/06 - Éléments ou leurs ensembles avec moyens pour augmenter la surface de transfert de chaleur, p. ex. avec des ailettes, avec des évidements, avec des ondulations les moyens pouvant être fixés sur l'élément
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
B06B 1/06 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique fonctionnant par effet piézo-électrique ou par électrostriction
H01L 23/367 - Refroidissement facilité par la forme du dispositif
65.
SYSTEMS AND METHODS FOR COOLING ULTRASOUND TRANSDUCERS AND ULTRASOUND TRANSDUCER ARRAYS
Ultrasound devices and systems are disclosed in which cooling of an active acoustic element of an ultrasound transducer is achieved via an electrically conductive member that extends beyond a proximal side of the active acoustic element to contact a heat exchanger. The electrically conductive member delivers electrical driving signals to the active acoustic element while conducting heat to the heat exchanger. A region of the proximal surface of the active acoustic element that is free from contact with the electrically conductive member may also absent from contact with a liquid or a solid, thereby facilitating reflection of ultrasound energy. The heat exchanger may include an electrically insulating fluid that contacts the electrically conductive member to remove the heat conducted through the electrically conductive member. The active acoustic element may be a multilayer lateral mode element, and the electrically conductive member may form an electrode of the lateral mode element.
B06B 1/02 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique
B06B 1/06 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique fonctionnant par effet piézo-électrique ou par électrostriction
F25D 31/00 - Autres appareils de refroidissement ou de congélation
F28D 21/00 - Appareils échangeurs de chaleur non couverts par l'un des groupes
F28F 7/00 - Éléments non couverts par les groupes , ou
H01L 23/46 - Dispositions pour le refroidissement, le chauffage, la ventilation ou la compensation de la température impliquant le transfert de chaleur par des fluides en circulation
H01L 41/02 - DISPOSITIFS À SEMI-CONDUCTEURS; DISPOSITIFS ÉLECTRIQUES À L'ÉTAT SOLIDE NON PRÉVUS AILLEURS - Détails - Détails
Ultrasound devices and systems are disclosed in which cooling of an active acoustic element of an ultrasound transducer is achieved via an electrically conductive member that extends beyond a proximal side of the active acoustic element to contact a heat exchanger. The electrically conductive member delivers electrical driving signals to the active acoustic element while conducting heat to the heat exchanger. A region of the proximal surface of the active acoustic element that is free from contact with the electrically conductive member may also absent from contact with a liquid or a solid, thereby facilitating reflection of ultrasound energy. The heat exchanger may include an electrically insulating fluid that contacts the electrically conductive member to remove the heat conducted through the electrically conductive member. The active acoustic element may be a multilayer lateral mode element, and the electrically conductive member may form an electrode of the lateral mode element.
B06B 1/02 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique
H01L 23/46 - Dispositions pour le refroidissement, le chauffage, la ventilation ou la compensation de la température impliquant le transfert de chaleur par des fluides en circulation
Disclosed herein is a tape, and related kits and methods, which is usable for scar care (e.g. for hypertrophic, keloid, or other scars). The tape may be used to treat, prevent, or inhibit scar pain, itching, and/or discomfort, and/or to improve or hasten scar healing, and/or to decrease scar height and redness, and/or to improve quality of life. The tape is highly stretchable along its width, but minimally stretchable or non-stretchable along its length. In use, the tape is placed over the scar, so that the length of the tape is aligned with the length of the scar, and stretched widthwise across the scar to pull the opposed sides of the scar towards each other.
Disclosed herein is a tape, and related kits and methods, which is usable for scar care (e.g. for hypertrophic, keloid, or other scars). The tape may be used to treat, prevent, or inhibit scar pain, itching, and/or discomfort, and/or to improve or hasten scar healing, and/or to decrease scar height and redness, and/or to improve quality of life. The tape is highly stretchable along its width, but minimally stretchable or non- stretchable along its length. In use, the tape is placed over the scar, so that the length of the tape is aligned with the length of the scar, and stretched widthwise across the scar to pull the opposed sides of the scar towards each other.
Formable mesh implants suitable for correcting bone implants are disclosed. A formable mesh may include a plurality of node plates that define a lattice, where connecting arms extend from each node plate. Each connecting arm associated with a given node plate connects with a plurality of adjacent connecting arms at a respective intermediate connection region, such that each connecting arm associated with the given node plate is connected to a different intermediate connection region, and such that neighboring node plates are indirectly connected through multiple connecting arms. At least a subset of the node plates may respectively include a screw-receiving aperture, and the intermediate connection regions may be absent of screw-receiving apertures. In another example embodiment, a formable mesh is disclosed in which each connecting arm of a given node plate connects with an adjacent node plate, where adjacent node plates are directly connected through at least two connecting arms.
A61F 2/00 - Filtres implantables dans les vaisseaux sanguinsProthèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corpsAppareils pour les assujettir au corpsDispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p. ex. stents
The present disclosure relates to a method of treating prostate cancer comprising administering to a subject in need thereof a therapeutically effective amount of a vasopressin analogue.
A61K 31/337 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à quatre chaînons, p. ex. taxol
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61P 35/04 - Agents anticancéreux spécifiques pour le traitement des métastases
A magnetically-tracked catheter system having a catheter and a magnetic beacon. The catheter has a proximal end and a distal end. The catheter includes a first magnetic sensor disposed at (i.e., near) the distal end. The magnetic beacon is configured to be disposed external to an individual and in a target zone. An operator interface is in electronic communication with the first magnetic sensor. The catheter may further include a guide lumen (and/or other lumen or lumens) extending between the proximal end and the distal end and the configured for use with a guidewire. The catheter may include an occlusion member configured to occlude a vessel or other passage of an individual (e.g, respiratory tract, gastrointestinal tract, etc.).
The present application is in the field of imaging reagents. In particular, the present application relates to labelled fluorocarbon imaging reagents, the preparation of the reagents, and their uses for imaging such as PET scanning.
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
A method of generating cells of the T cell lineage is provided comprising (a) culturing a sample comprising stem cells or progenitor cells with a Notch ligand conjugated to a suspension support and (b) isolating cells of the T cell lineage. In one embodiment, the cells of the T-cell lineage are progenitor T cells or mature T cells. Compositions, kits and uses thereof are also provided.
Various example embodiments of the present disclosure provide systems and methods for the dynamic correction and reduction of thermal variations in skull-induced aberrations during a focused ultrasound therapy procedure. Unlike conventional approaches involving static corrections for skull-induced aberrations, various example embodiments of the present disclosure employ ultrasound detection and a skull thickness estimate from volumetric image data to intermittently and dynamically determine corrections for skull-induced aberrations, such that aberration correction reduction is updated intraoperatively and maintained despite local thermally-induced changes in the speed of sound of the local skull region due to intraoperative intracranial heating. Furthermore, in some example embodiments, a measure dependent on the speed of sound with the skull is intraoperatively determined and compared to a previously determined value of the measure to determine a change in the skull temperature, based on a pre-determined relationship between changes in the measure and changes in skull temperature.
Various example embodiments of the present disclosure provide systems and methods for the dynamic correction and reduction of thermal variations in skull-induced aberrations during a focused ultrasound therapy procedure. Unlike conventional approaches involving static corrections for skull-induced aberrations, various example embodiments of the present disclosure employ ultrasound detection and a skull thickness estimate from volumetric image data to intermittently and dynamically determine corrections for skull-induced aberrations, such that aberration correction reduction is updated intraoperatively and maintained despite local thermally-induced changes in the speed of sound of the local skull region due to intraoperative intracranial heating. Furthermore, in some example embodiments, a measure dependent on the speed of sound with the skull is intraoperatively determined and compared to a previously determined value of the measure to determine a change in the skull temperature, based on a pre-determined relationship between changes in the measure and changes in skull temperature.
13C-MRI. The metabolite profiles can be generated by parcellating the magnetic resonance images into different regions, computing z-scores for those regions, and generating the metabolite profile based on the computed z-scores.
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
79.
SYSTEMS AND METHODS FOR A BALLOON CATHETER SUPPORT SLEEVE
A system and method for widening a narrowed blood vessel in a patient, the system including a guidewire, a balloon catheter having an enlarging balloon, and a tubular support sleeve having at least one support balloon. The support balloon is inflated to mechanically support the advancement of the balloon catheter into a narrowed segment of the blood vessel.
A system and method for widening a narrowed blood vessel in a patient, the system including a guidewire, a balloon catheter having an enlarging balloon, and a tubular support sleeve having at least one support balloon. The support balloon is inflated to mechanically support the advancement of the balloon catheter into a narrowed segment of the blood vessel.
A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
The present disclosure provides a cardio pulmonary resuscitation (CPR) apparatus for performing a chest compression on a patient supported by a support. The apparatus includes an actuator operatively coupled to a compression mechanism for actuating the compression mechanism to perform the chest compression. The compression mechanism is securable to the support and is configured to repeatedly perform chest compressions on the patient in an operating space, the operating space being the space in which the compression mechanism operates. The actuator is positioned outside of the operating space. The present disclosure further provides a monitoring system having the CPR apparatus and a feedback system coupled to the CPR apparatus.
Magnetic resonance (“MR”) visible markers for use in MR-guided placement of brachytherapy seeds, and for use in other MR-guided interventional procedures, are described. The MR-visible markers generally include a tube in which an absorbent thread assembly is disposed. The tube is made fluid-tight by sealing it at both ends with suitable end plugs. The absorbent thread assembly is soaked in a suitable MR-visible fluid.
Systems and methods for using quantitative ultrasound (“QUS”) techniques to generate imaging biomarkers that can be used to assess a prediction of tumor response to different chemotherapy treatment regimens are provided. For instance, the imaging biomarkers can be used to subtype tumors that have resistance to certain chemotherapy regimens prior to drug exposure. These imaging biomarkers can therefore be useful for predicting tumor response and for assessing the prognostic value of particular treatment regimens.
A catheter device for lumen re-entry is provided. The catheter device includes a catheter shaft having a lumen extending from a proximal end to a distal end and an expandable member positioned at the distal end of the catheter shaft. The catheter shaft having interior walls defining a central lumen extending from a proximal end to a distal end along a longitudinal axis of the lumen. The expandable member configured to receive a fluid that selectively expands the expandable member from a first volume to a second volume, the second volume being larger than the first volume to provide a deflection surface that is oriented at an angle with respect to the longitudinal axis of the lumen. The deflection member provides a surface to angle a guidewire out of the distal opening at the tip of the catheter shaft (i.e., not a separate side-facing hole].
The present disclosure provides a deep orbital access retractor (DOAR) device which includes a manipulable body section including a compressible handle having a size and shape to be manipulated by at least two (2) digits of a clinician. A flexible head section having two (2) arms with each arm having a distal end and a proximal end, with the distal ends of the arms spaced apart forming a gap there-between at a distal tip section. A flexible flange material envelops and encloses the two arms and the gap and extends around a periphery of the flexible head section. A flexible diaphragm is attached to and extends between the two arms to provide a generally spoon-shaped flexible head section. The flexible head section is linked to the compressible handle section with the linkage being configured such that upon compression of the handle section the arms articulate with respect to each other thereby causing narrowing of the flexible head section to allow for insertion into the orbit and positioning between soft tissue and bone while the flexible diaphragm remains in sufficient tension to not obstruct the view of the operator into the orbit. When compression is released the flexible diaphragm develops sufficient tension and rigidity for applying sufficient force to retract the orbital contents of a patient to allow access to orbital walls.
The present disclosure provides a deep orbital access retractor (DOAR) device which includes a manipulable body section including a compressible handle having a size and shape to be manipulated by at least two (2) digits of a clinician. A flexible head section having two (2) arms with each arm having a distal end and a proximal end, with the distal ends of the arms spaced apart forming a gap there-between at a distal tip section. A flexible flange material envelops and encloses the two arms and the gap and extends around a periphery of the flexible head section. A flexible diaphragm is attached to and extends between the two arms to provide a generally spoon-shaped flexible head section. The flexible head section is linked to the compressible handle section with the linkage being configured such that upon compression of the handle section the arms articulate with respect to each other thereby causing narrowing of the flexible head section to allow for insertion into the orbit and positioning between soft tissue and bone while the flexible diaphragm remains in sufficient tension to not obstruct the view of the operator into the orbit. When compression is released the flexible diaphragm develops sufficient tension and rigidity for applying sufficient force to retract the orbital contents of a patient to allow access to orbital walls.
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Canada)
Inventeur(s)
Mandelis, Andreas
Choi, Sung Soo
Lashkari, Bahman
Courtney, Brian
Foster, Stuart
Abrégé
Systems and methods are disclosed that facilitate the reduction of both radio frequency (RF) noise and photoacoustic artefacts in differential photoacoustic radar imaging through a multi-step electrical and optical domain calibration method. An example two-step calibration method involves reducing RF image noise via an initial calibration step that involves the control of the relative amplitudes and phases of electrical driving modulation waveforms, while a second calibration step involves the differential suppression of photoacoustic artefact signals via tuning, in the optical domain, of the relative intensity the optical beams that are delivered to the sample. Another example embodiment involves the use of the standard deviation of the unwrapped phase that is obtained, after performing frequency-domain cross-correlation and an inverse transform to the time domain, to improve the amplitude signal that is employed to generate a differential photoacoustic radar image.
G01N 29/14 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet utilisant des techniques d'émission acoustique
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
89.
SYSTEMS AND METHODS FOR PERFORMING FREQUENCY-DOMAIN PHOTOACOUSTIC IMAGING
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Canada)
Inventeur(s)
Mandelis, Andreas
Choi, Sung Soo
Lashkari, Bahman
Courtney, Brian
Foster, Stuart
Abrégé
Systems and methods are disclosed that facilitate the reduction of both radio frequency (RF) noise and photoacoustic artefacts in differential photoacoustic radar imaging through a multi-step electrical and optical domain calibration method. An example two-step calibration method involves reducing RF image noise via an initial calibration step that involves the control of the relative amplitudes and phases of electrical driving modulation waveforms, while a second calibration step involves the differential suppression of photoacoustic artefact signals via tuning, in the optical domain, of the relative intensity the optical beams that are delivered to the sample. Another example embodiment involves the use of the standard deviation of the unwrapped phase that is obtained, after performing frequency-domain cross-correlation and an inverse transform to the time domain, to improve the amplitude signal that is employed to generate a differential photoacoustic radar image.
G01N 29/14 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet utilisant des techniques d'émission acoustique
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
An apparatus for slicing a cartilage sample includes a rear cartilage support cup, a cartilage clamp, a front cartilage support, a cartilage receiving region, and a cartilage cutting element. The cartilage clamp has first and second clamp members spaced apart from and aligned in a clamping direction transverse to a longitudinal axis. The cartilage receiving region is bounded by the first and second clamp members, the front cartilage support, and the rear cartilage support cup. The cartilage cutting element is spaced rearward ly from the front cartilage support by a cartilage slice thickness, the cartilage cutting element being movable across the cartilage receiving region in a cutting direction transverse to the longitudinal axis.
An apparatus for slicing a cartilage sample includes a rear cartilage support cup, a cartilage clamp, a front cartilage support, a cartilage receiving region, and a cartilage cutting element. The cartilage clamp has first and second clamp members spaced apart from and aligned in a clamping direction transverse to a longitudinal axis. The cartilage receiving region is bounded by the first and second clamp members, the front cartilage support, and the rear cartilage support cup. The cartilage cutting element is spaced rearward ly from the front cartilage support by a cartilage slice thickness, the cartilage cutting element being movable across the cartilage receiving region in a cutting direction transverse to the longitudinal axis.
A system and method is provided for generating ultrasound at the tip of an intravascular catheter. This may be used for the treatment of vascular occlusions, including chronic total occlusions (CTOs) and thrombotic occlusions (e.g., deep vein thrombosis, stroke, myocardial infarction). For instance, the systems and methods may be used to induce cavitation to enhance the enzymatic degradation of a vascular occlusion. In some configurations, the approach employs a hollow cylindrical transducer, electrically stimulated in the radial direction at a frequency corresponding to the length mode excitation, thereby projecting ultrasound forwards past the catheter tip. This design overcomes electrical impedance issues for the generation of low frequencies with a smaller diameter transducer capable of negotiating a coronary artery. The hole within the transducer may accommodate a guidewire to facilitate its placement adjacent to the proximal portion of the occlusion.
A61B 17/22 - Instruments pour comprimer les ulcères ou similaires placés sur les organes internes du corpsInstruments pour curer les cavités des organes du corps, p. ex. des osInstruments, dispositifs ou procédés chirurgicaux pour l'élimination ou la destruction invasives des calculs utilisant des vibrations mécaniquesInstruments, dispositifs ou procédés chirurgicaux pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p. ex. en utilisant des cathéters
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
93.
SYSTEMS AND METHODS FOR TREATING VASCULAR OCCLUSIONS WITH CATHETER BASED ULTRASOUND
A system and method is provided for generating ultrasound at the tip of an intravascular catheter. This may be used for the treatment of vascular occlusions, including chronic total occlusions (CT0s) and thrombotic occlusions (e.g., deep vein thrombosis, stroke, myocardial infarction). For instance, the systems and methods may be used to induce cavitation to enhance the enzymatic degradation of a vascular occlusion. In some configurations, the approach employs a hollow cylindrical transducer, electrically stimulated in the radial direction at a frequency corresponding to the length mode excitation, thereby projecting ultrasound forwards past the catheter tip. This design overcomes electrical impedance issues for the generation of low frequencies with a smaller diameter transducer capable of negotiating a coronary artery. The hole within the transducer may accommodate a guidewire to facilitate its placement adjacent to the proximal portion of the occlusion.
A61B 17/22 - Instruments pour comprimer les ulcères ou similaires placés sur les organes internes du corpsInstruments pour curer les cavités des organes du corps, p. ex. des osInstruments, dispositifs ou procédés chirurgicaux pour l'élimination ou la destruction invasives des calculs utilisant des vibrations mécaniquesInstruments, dispositifs ou procédés chirurgicaux pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
The present disclosure relates to a method of treating prostate cancer comprising administering to a subject in need thereof a therapeutically effective amount of a vasopressin analogue.
A61K 31/337 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à quatre chaînons, p. ex. taxol
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61P 35/04 - Agents anticancéreux spécifiques pour le traitement des métastases
Systems and methods are provided for the denoising of images in the presence of broadband noise based on the detection and/or estimation of in-band noise. According to various example embodiments, an estimate of broadband noise that lies within the imaging band is made by detecting or characterizing the out-of-band noise that lies outside of the imaging band. This estimated in-band noise may be employed for denoise the detected imaging waveform. According to other example embodiments, a reference receive circuit that is sensitive to noise within the imaging band, but is isolated from the imaging energy, may be employed to detect and/or characterize the noise within the imaging band. The estimated reference noise may be employed to denoise the detected in-band imaging waveform.
Described here are systems and methods for positioning a surgical implant, such as a glenoid component, or other medical device intra-operatively. In general, the systems and methods described in the present disclosure implement a computer vision system, which may be a structured light computer vision system, together with a suitable optical tracker as an accurate intra-operative tool for predicting post-operative implant position in surgical procedures.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61F 2/46 - Outils particuliers pour l'implantation des articulations artificielles
A61B 17/17 - Dispositifs de guidage pour les forets
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
97.
SYSTEMS AND METHODS FOR SURGICAL IMPLANT GUIDANCE AND POSITIONING WITH OPTICAL SURFACE IMAGING
Described here are systems and methods for positioning a surgical implant, such as a glenoid component, or other medical device intra-operatively. In general, the systems and methods described in the present disclosure implement a computer vision system, which may be a structured light computer vision system, together with a suitable optical tracker as an accurate intra-operative tool for predicting post-operative implant position in surgical procedures.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Canada)
SUNNYBROOK RESEARCH INSTITUTE (Canada)
Inventeur(s)
Hakimi, Navid
Cheng, Richard Yihsiu
Sotoudehfar, Mohammad Hadi
Ba, Qing
Amini-Nik, Saeid
Jeschke, Marc G.
Guenther, Axel
Abrégé
Disclosed herein is a bioprinter that enables the in situ formation of architected planar biomaterials and tissues by translating a printer head along a deposition surface, such as skin wounds. In handheld configurations of of the instrument, cell-laden biopolymer solutions are perfused through a moving microfabricated printhead and deposited onto a stationary planar surface or a wound. The printer head may be translated via a drive mechanism. Different embodiments of the instrument are disclosed form vivo application in small animals, as well as for large animal and clinical application. A stationary embodiment of the instrument is well suited for the continuous formation and roll-to-roll processing of planar biomaterials and tissues.
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Canada)
Inventeur(s)
Cheng, Richard
Eylert, Gertraud
He, Sijin
Gariépy, Jean-Michel
Hakimi, Navid
Jeschke, Marc G.
Guenther, Axel
Abrégé
Disclosed herein is an instrument that enables the in situ formation of architected planar biomaterials and tissues by translating a printer head along a deposition surface such as a patient having burn injuries. In handheld embodiments of the instrument, cell-laden biopolymer solutions are perfused through a moving microfabricated printer head and deposited onto a stationary planar surface or a wound. The printer head may be translated via a drive mechanism. A soft deformable roller mitigates further damage to the injured area of skin as it rolls over it and a gimbal mechanism to which the printer head is attached is in contact with the injured tissue but is configured so that the printer head while in contact with tissue, does not exert undue pressure on the would area.
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Canada)
Inventeur(s)
Cheng, Richard
Eylert, Gertraud
He, Sijin
Gariepy, Jean-Michel
Hakimi, Navid
Jeschke, Marc G.
Guenther, Axel
Abrégé
Disclosed herein is an instrument that enables the in situ formation of architected planar biomaterials and tissues by translating a printer head along a deposition surface such as a patient having burn injuries. In handheld embodiments of the instrument, cell-laden biopolymer solutions are perfused through a moving microfabricated printer head and deposited onto a stationary planar surface or a wound. The printer head may be translated via a drive mechanism. A soft deformable roller mitigates further damage to the injured area of skin as it rolls over it and a gimbal mechanism to which the printer head is attached is in contact with the injured tissue but is configured so that the printer head while in contact with tissue, does not exert undue pressure on the would area.
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
A61M 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
A61M 35/00 - Dispositifs pour appliquer des agents, p. ex. des remèdes, sur le corps humain
B41J 3/407 - Machines à écrire ou mécanismes d'impression ou de marquage sélectif caractérisés par le but dans lequel ils sont construits pour le marquage sur des matériaux particuliers
C08J 3/28 - Traitement par ondes énergétiques ou par rayonnement de particules
brevets
