The present invention concern a power line engagement system (1) for an electrically powered aerial vehicle (3) comprising a propulsion system, a navigation system capable of steering the aerial vehicle towards an overhead 5 power line (2), a rechargeable battery and a power line charging unit for recharging the battery, said engagement system (1) comprising a magnetic core (8) comprising at least two parts of a magnetic core (8a, 8b); a magnetic gripping mechanism for connecting to the power line (2) for forming at least one current transformer (12) that closes around the power line (2), wherein said gripping 10 mechanism comprises two case cores (6a, 6b) that are pivotally connected and having extensions (20) at their distal end; wherein the gripping mechanism is adapted to open and disengage from the power line (2) in the event of electrical failures in the system, wherein the gripping mechanism is arranged to grip the power line (2) from below, allowing the aerial vehicle (3) to suspend from the 15 power line (2), wherein the gripping mechanism is adapted such that upon gripping, at least one rope (5), which connects each ends of the gripper, closes the gripper comprising the at least two parts of a magnetic core (8a, 8b), which upon closing are configured such that the magnetic core parts (8a, 8b) are pulled towards each other, closing the system. Hereby, a simplified design is provided 20 which contributes to enhanced reliability, making it a significant advancement in aerial vehicle technology.
H02G 1/02 - Méthodes ou appareils spécialement adaptés à l'installation, entretien, réparation, ou démontage des câbles ou lignes électriques pour lignes ou câbles aériens
B64U 50/30 - Alimentation en énergie électrique ou distribution de celle-ci
H02J 7/00 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries
2.
ALLELE SPECIFIC SPLICE SWITCHING OLIGONUCLEOTIDES TARGETING PSEUDOEXONS
The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5′ splice site of said pseudoexon. The invention also relates to SSOs obtained by said method and uses thereof. In particular, the present invention relates to allele specific splice switching oligonucleotides (SSOs).
A heat exchanger apparatus for temperature regulation in a building an inlet section with a wedge-shaped inlet channel having a wide opening at an air inlet and a gradually narrowing cross-section. The inlet channel has a side-opening towards a heat exchange section. The heat exchange section has plate-shaped phase change material modules mounted in an inclined stacked formation forming a series of air channels between the PCM modules extending from the inlet section to the wedge-shaped outlet section so that the airflow is gradually redirected from the inlet section and into the air channels of the heat exchange section. The heat exchanger with PCM plate modules has a low pressure drop meaning low additional energy consumption, and the heat exchanger has a very even airflow offering a system that provides effective cooling until all energy stored in the PCM plate modules is dispatched.
A method and system is for tracking motion of a wind turbine blade. A blade motion tracking system is for installation on a wind turbine blade with a blade root and tip. The system has at least one light module with at least a first light source, preferably adapted to emit light in the blade root direction. An optical measuring device at the blade root may receive light emitted from the first source. The optical measuring device may be a position sensitive detector identifying the first light source position relative to the position sensitive detector. A single light source located at, close to, or towards the tip, is sufficient to measure blade deflection. The first light source is modulated with a predefined frequency such that light from the first light source can be distinguished from ambient light and thereby minimize the influence of the ambient light conditions during detection.
The present invention concerns a system and a method for collision avoidance of a 3D robotic concrete printer, whereby the method comprises the steps of performing an application and/or manipulation process by executing instructions, such as based on G-Code, with a 3D robotic concrete printer by moving a tool in a path for applying and/or manipulating concrete material; and moving the tool in response to commands to a motion planner, said movement being assisted by a model-based collision prediction system, whereby the model-based collision-prediction system involves the steps of inferring and generating 3D geometries of concrete structures from applying and/or manipulating concrete structures by commanding the 3D robotic concrete printer, using the 3D geometries as a 3D collision model, which allow at any point in time to check if parts of the 3D robotic concrete printer would yield a collision when performing said movement; whereby the 3D collision model of the concrete structure is developed in parallel to the application and/or manipulation process and is updated in correspondence to the progress of the execution of the process instructions.
Reliable non-invasive biomarkers are an unmet clinical need for the diagnosis of NASH patients. Herein we identify soluble TREM2 as a non-invasive plasma biomarker to diagnose NASH in obese patients and provides evidence for sTREM2 as an accurate predictor of advanced hepatic inflammation, ballooning, and fibrosis.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
7.
INHIBITORS FOR USE IN PREVENTION- AND/OR ALLEVIATION OF HEART FIBROSIS
Inhibitors for use in preventing and/or alleviation of increased fibrotic scar tissue formation caused by a disease or a complication of the heart, such as a myocardial infarction or surgery. The inhibitors may inhibit activity of the Delta Like Non-Canonical Notch Ligand 1 (Dlk1) protein or the integrin beta-8 (Itgb8) protein.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
The invention relates to a system and method for providing the depth and orientation of a surgical instrument inserted into biological tissue. The system comprises a surgical instrument adapted to emit light into the biological tissue and a light detection device outside said tissue, and wherein an algorithm is adapted to provide said depth and orientation information, based on light scatter detected by the light detection device; and a peripheral user interface adapted to receive and display said information to a user if the surgical instrument, such as a health care person. In particular, the invention is advantageous for deep vessel insertion or aiding e.g. a nurse in reaching a small blood vessel of e.g. an infant or small child with a cannula. Further, the invention is advantageous for training health care personnel to improve their needle insertion technique, such as with a training phantom and provide decision support during needle insertion.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 5/06 - Dispositifs autres que ceux à radiation, pour détecter ou localiser les corps étrangers
The present invention relates to methods of detecting delayed graft function of kidney transplant as well as detecting acute kidney injury. In particular, the present invention relates to antibodies against extracellular regions of AQP2 and methods of detecting urinary extracellular vesicles, which is especially useful in the firstly described methods.
A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
10.
COMPOUNDS AND METHODS FOR TREATING AND/OR ALLEVIATING THE SIDE EFFECTS OF MYOCARDIAL INFARCTION
The present invention relates to compounds capable of modulating Zeb1. In particular, the present invention relates to compounds capable of modulating the transcription factor Zeb1 for use in a treatment of the myocardium after myocardial infarction. Furthermore, the present invention provides an ex vivo method of maturing iPS CM, the method comprising, administering to an iPS CM a compound capable of decreasing the levels of Zeb1. Lastly, the present invention relates to a method of treatment of the myocardium in a subject having experienced myocardial infarction.
The present invention relates to a method for determining the response to bisphosphonate treatment and/or early mortality by determining the genotype of selected single nucleotide polymorphisms (SNPs). In particular, the present invention relates to a method for determining the risk of non-response to bisphosphonate treatment and/or early mortality by determining the genotype of selected SNPs in a subject suffering from bone-related diseases such as osteoporosis or bone-metastasized cancer. Furthermore, the present invention relates to a device for determining the SNP profile and uses thereof.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
12.
A METHOD OF PASSIVATING SURFACE EFFECTS IN METAL OXIDE LAYERS AND DEVICES COMPRISING THEREOF
The present invention relates to a method of producing a metal oxide layer on a substrate, to a method of producing an optoelectronic device or an electrochemical device and to an optoelectronic device comprising a metal oxide layer.
H10K 30/10 - Dispositifs organiques sensibles au rayonnement infrarouge, à la lumière, au rayonnement électromagnétique de plus courte longueur d'onde ou au rayonnement corpusculaire comprenant des hétérojonctions entre des semi-conducteurs organiques et des semi-conducteurs inorganiques
The present invention relates to the provision of novel sources of microglia-like cells having a unique phenotype. In particular, the present invention relates to medical uses of such microglia-like cells, in particular in relation to treatment of neurodegenerative diseases.
The present invention relates to bifunctional electrocatalyst for hydrogen electrooxidation and oxygen evolution reactions in water electrolyzers. The present invention also relates to a method to produce the bifunctional electrocatalyst and the PEM electrolyzer comprising the bifunctional electrocatalyst.
The present invention relates to a process for providing a jellyfish-based product, said process comprises the steps: providing at least one raw jellyfish; freeze-drying the jellyfish, pulverizing the freeze-dried jellyfish; and thereby provide a jellyfish-based product. The invention also relates to uses of such jellyfish-based product, such as a gelling agent, an emulsifier, an oleogelling agent, and a foaming agent.
A23L 3/40 - Conservation des aliments ou produits alimentaires, en général, p.ex. pasteurisation ou stérilisation, spécialement adaptée aux aliments ou produits alimentaires par séchage ou étuvage; Reconstitution ultérieure
A23D 7/005 - Compositions à base d'huiles ou de graisses comestibles contenant une phase aqueuse, p. ex. margarines caractérisées par des ingrédients autres que des triglycérides d'acides gras
A23D 7/02 - Compositions à base d'huiles ou de graisses comestibles contenant une phase aqueuse, p. ex. margarines caractérisées par leur production ou leur traitement
A23J 1/04 - Préparation des compositions à base de protéines pour l'alimentationOuverture des œufs par grandes quantités et séparation du jaune du blanc à partir du poisson ou d'autres animaux marins
The present invention concerns a Phase Changing Material module for a heat exchanger apparatus, wherein the module comprises a first plate shell and a second plate shell, both shells having an undulated wave surface with a smooth, periodic oscillation, and wherein both said plates have a rectangular peripheral edge portion; and wherein said first and second plate shells are joined together along their peripheral edges to form an internal volume which is filled with a phase changing material.
F28D 9/00 - Appareils échangeurs de chaleur comportant des ensembles de canalisations fixes en forme de plaques ou de laminés pour les deux sources de potentiel calorifique, ces sources étant en contact chacune avec un côté de la paroi d'une canalisation
F24F 5/00 - Systèmes ou appareils de conditionnement d'air non couverts par ou
F28D 20/02 - Appareils ou ensembles fonctionnels d'accumulation de chaleur en généralAppareils échangeurs de chaleur de régénération non couverts par les groupes ou utilisant la chaleur latente
F28F 3/04 - Éléments ou leurs ensembles avec moyens pour augmenter la surface de transfert de chaleur, p. ex. avec des ailettes, avec des évidements, avec des ondulations les moyens faisant partie intégrante de l'élément
F28F 21/06 - Structure des appareils échangeurs de chaleur caractérisée par l'emploi de matériaux spécifiés de matériau plastique
F28D 20/00 - Appareils ou ensembles fonctionnels d'accumulation de chaleur en généralAppareils échangeurs de chaleur de régénération non couverts par les groupes ou
17.
USE OF SMOC2 AS A NON-INVASIVE BIOMARKER FOR DEVELOPING ALCOHOLIC OR NON-ALCOHOLIC STEATOHEPATITIS
The present invention relates to a method for determining the risk of a subject having or developing NASH or ASH, the method comprising A) determining in a blood sample from a subject, the level of SPARC-related modular calcium-binding protein 2 (SMOC2); B) comparing said determined level to a reference level; and determining that said subject is at risk of having NASH or ASH, if said level is above said reference level, or determining that said subject is not at risk of having NASH or ASH if said level is equal to or below said reference level. The present invention also relates to a method for determining the effect of a treatment protocol against NASH or ASH for a subject as well as use of blood sample levels of SMOC2 from a subject as a biomarker for the risk of said subject of having or developing NASH or ASH, or staging NASH or ASH for said subject.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
18.
VITAMIN K2 FOR USE IN TREATMENT OF CORONARY ARTERY CALCIFICATION
The present invention relates to high-dose vitamin K2, in particular menaquinone-7 (MK- 7), for use in the treatment of coronary heart disease in high-risk subjects having a coronary artery calcification (CAC) score ≥400 (e.g. at the onset of the treatment), wherein the treatment results in slowing of the progression calcification in the coronary 5 arteries.
A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
A61K 31/592 - Dérivés du 9,10-séco-ergostane, p. ex. ergocalciférol, vitamine D2
A61K 31/593 - Dérivés du 9,10-séco-cholestane, p. ex. cholécalciférol, vitamine D3
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
19.
HOLOGRAPHIC SYSTEM WITH IMPROVED PROJECTION QUALITY
The invention relates to a method for generating a pixelated projection in a reconstruction space. The method includes determination of a first discretized hologram, wherein the first discretized hologram is determined to generate a desired amplitude profile of an output pixel in the reconstruction space; determination of a second discretized hologram having a phase distribution determined to create a desired projection in the reconstruction space; determination of a tiled hologram by tiling the second discretized hologram a number of one or more times in one or two directions, wherein the number of tilings and the first discretized hologram are determined subject to an output pixel constraint determined based on a dimension of the amplitude profile of the output pixel in the reconstruction space and a pixel pitch in the reconstruction space. A composite hologram is determined based on a phasor multiplication of the first discretized hologram and the tiled hologram. A coherent input beam is phase modulated based on the composite hologram so that the phase modulated beam generates the pixelated projection in the reconstruction space. A particular application of the invention is the use for volumetric additive manufacturing (VAM), especially for medical use, such as implants.
G03H 1/08 - Procédés ou appareils pour produire des hologrammes pour faire des hologrammes synthétiques
G03H 1/22 - Procédés ou appareils pour obtenir une image optique à partir d'un hologramme
G03H 1/30 - Procédés ou appareils adaptés spécialement pour produire des hologrammes multiples ou pour en obtenir des images, p. ex. procédés pour l'holographie à plusieurs couleurs uniquement des hologrammes séparés
G03H 1/32 - Systèmes pour éliminer la granulation d'image
LGR5 binding agents, in particular antibodies or fragments thereof which bind to human LGR5, and the use of such binding agents in the treatment of disease, such as cancer and inflammatory disease, and the detection of LGR5.
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
LGR5 binding agents, in particular antibodies or fragments thereof which bind to human LGR5, and the use of such binding agents in the treatment of disease, such as cancer and inflammatory disease, and the detection of LGR5.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
22.
SOFT-SWITCHING PULSE-WIDTH MODULATED DC-DC POWER CONVERTER
A switch-mode DC-DC power converter including an input port and an output port, wherein the switch-mode DC-DC power converter includes a hard-switching circuit. The switch-mode DC-DC power converter further includes a first capacitance, a first inductance and a soft-switching circuit. The first capacitance is coupled in parallel across one of input and output ports at one side of the hard-switching circuit whereas the first inductance is coupled in series with another of the input and output ports and the hard-switching circuit at a second side of the hard-switching circuit opposite the first capacitance. A soft-switching circuit includes a second capacitance, a second inductance, a first rectifying element and a controlled discharger. The first rectifying element is coupled to the second inductance and the second capacitance. The controlled discharger is coupled to the second capacitance.
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
H02M 1/14 - Dispositions de réduction des ondulations d'une entrée ou d'une sortie en courant continu
H02M 1/00 - Détails d'appareils pour transformation
23.
ALLELE SPECIFIC SPLICE SWITCHING OLIGONUCLEOTIDES TARGETING PSEUDOEXONS
The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSOs obtained by said method and uses thereof. In particular, the present invention relates to allele specific splice switching oligonucleotides (SSOs).
The invention relates to a heat exchanger apparatus for temperature regulation in a building. The apparatus has an inlet section (2) with a wedge-shaped inlet channel having a wide opening at an air inlet and a gradually narrowing cross-section, and wherein the inlet channel has a side-opening towards a heat exchange section (4). The heat exchange section has plate-shaped phase change material (PCM) modules (8) mounted in an inclined stacked formation forming a series of air channels (40) between the PCM modules extending from the inlet section to the wedge-shaped outlet section (6) so that the airflow is gradually redirected from the inlet section and into the air channels of the heat exchange section. The heat exchanger with PCM plate modules has a low pressure drop meaning low additional energy consumption, and the heat exchanger has a very even airflow offering a system that provides effective cooling until all energy stored in the PCM plate modules is dispatched.
Compounds of formula (1) comprising a pleuromutilin backbone with a triazole based side-group at C22 are provided. The compounds can be used for treatment of bacterial infections and fungal infections. Importantly, infections caused by multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) may be treated effectively.
Compounds of formula (1) comprising a pleuromutilin backbone with a triazole based side-group at C22 are provided. The compounds can be used for treatment of bacterial infections and fungal infections. Importantly, infections caused by multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) may be treated effectively.
C07D 403/10 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles aromatiques
The present invention relates to a modified peptide-oligonucleotide conjugates (POC) composed of a cell-penetrating peptide (CPP) conjugated to an antisense oligonucleotide. The POC is able to regulate gene expression in the target cells and can thus be used in treatment of different disease such as bacterial infections and cancer.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61K 31/712 - Acides nucléiques ou oligonucléotides ayant des sucres modifiés, c.-à-d. autres que le ribose ou le 2'-désoxyribose
A61K 31/7125 - Acides nucléiques ou oligonucléotides ayant des liaisons internucléosides modifiées, c.-à-d. autres que des liaisons 3'-5' phosphodiester
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
The present invention concerns a system and a method for collision avoidance of a 3D robotic concrete printer, whereby the method comprises the steps of performing an application and/or manipulation process by executing instructions, such as based on G-Code, with a 3D robotic concrete printer by moving a tool in a path for applying and/or manipulating concrete material; and moving the tool in response to commands to a motion planner, said movement being assisted by a model-based collision prediction system, whereby the model-based collision-prediction system involves the steps of inferring and generating 3D geometries of concrete structures from applying and/or manipulating concrete structures by commanding the 3D robotic concrete printer, using the 3D geometries as a 3D collision model, which allow at any point in time to check if parts of the 3D robotic concrete printer would yield a collision when performing said movement; whereby the 3D collision model of the concrete structure is developed in parallel to the application and/or manipulation process and is updated in correspondence to the progress of the execution of the process instructions.
G05B 19/4061 - Évitement des collisions ou des zones interdites
B22F 10/85 - Acquisition ou traitement des données pour la commande ou la régulation de procédés de fabrication additive
B29C 64/00 - Fabrication additive, c.-à-d. fabrication d’objets en trois dimensions [3D] par dépôt additif, agglomération additive ou stratification additive, p. ex. par impression en 3D, stéréolithographie ou frittage laser sélectif
The present invention relates to antibodies, including humanized antibodies that bind human Microfibrillar-associated protein 4 (MFAP4). The invention also relates to uses of such antibodies.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
30.
Power module with an integrated aluminium snubber capacitor
Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung E. V. (Allemagne)
Inventeur(s)
Ebel, Thomas
Schletz, Andreas
Abrégé
This invention concerns a power module comprising a power device, a baseplate, circuit carrier, and a flat stacked aluminium electrolytic snubber capacitor comprising a layered structure of a cathode layer, a separator layer, comprising paper and an electrolyte and an anode layer, comprising an aluminium material with an aluminium oxide dielectric, wherein the circuit carrier are mounted on the baseplate, the power device and snubber capacitor are placed on the circuit carrier within the power module and electrically connected to the circuit carrier, the circuit carrier being configured for providing an electrical connection between the power device and the snubber capacitor.
H01G 2/06 - Dispositifs de montage spécialement adaptés pour le montage sur un support de circuit imprimé
H01G 9/00 - Condensateurs électrolytiques, redresseurs électrolytiques, détecteurs électrolytiques, dispositifs de commutation électrolytiques, dispositifs électrolytiques photosensibles ou sensibles à la températureProcédés pour leur fabrication
H01G 9/035 - Électrolytes liquides, p. ex. matériaux d'imprégnation
H01G 9/045 - Électrodes caractérisées par le matériau à base d'aluminium
H01G 9/28 - Combinaisons structurales de condensateurs électrolytiques, de redresseurs électrolytiques, de détecteurs électrolytiques, de dispositifs de commutation électrolytiques, avec d'autres composants électriques non couverts par la présente sous-classe
H05K 5/00 - Enveloppes, coffrets ou tiroirs pour appareils électriques
H05K 7/00 - Détails de construction communs à différents types d'appareils électriques
The present invention relates to a method of recovering iridium in the form of iridium solutions, metal, oxides or salts from a body, such as a spent catalyst, comprising iridium oxides.
Inhibitors for use in preventing and/or alleviation of increased fibrotic scar tissue formation caused by a disease or a complication of the heart, such as a myocardial infarction or surgery. The inhibitors may inhibit activity of the Delta Like Non-Canonical Notch Ligand 1 (Dlk1) protein or the integrin beta-8 (Itgb8) protein.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C07K 16/22 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des facteurs de croissance
A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
33.
BLOWER HEAD FOR PROVIDING A WIDE-ANGULAR AIRSTREAM AND DRONE OR DEVICE FOR DISPENSING BIOLOGICAL MATERIAL
The invention relates to a blower head (13) for providing a wide-angular airstream. It comprises an inner chamber (17), an inlet (18) for entry of a flow of air into the inner chamber (17), and an outlet (15) for exit of air from the inner chamber (17). The inlet is configured to be in fluid communication with a blower (14) for providing the flow of air when in use. The outlet is in the form of an elongated aperture (15) facing away from the blower head. The inner chamber is dimensioned and shaped so that air flowing through the inner chamber changes direction by hitting inner walls (19) of the inner chamber in a manner resulting in a wide-angular airstream exiting the outlet. The invention further relates to a drone (1) or a device (25) and a method for dispensing biological material (11), such as beneficial animals, by using the blower head to apply an airstream to the biological material being dispensed.
Reliable non-invasive biomarkers are an unmet clinical need for the diagnosis of NASH patients. Herein we identify soluble TREM2 as a non-invasive plasma biomarker to diagnose NASH in obese patients and provides evidence for sTREM2 as an accurate predictor of advanced hepatic inflammation, ballooning, and fibrosis.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
35.
End effector including resilient members between adjacent holding tools
An end effector for handling a sheet of flexible material. The end effector includes a support frame and manipulator assemblies, each attached to the support frame by a support mount. The manipulator assemblies include a holding tool having a lifting surface. The manipulator assemblies include a linear actuator, and the holding tool is connected to the linear actuator by a multiaxial joint. A drive provides—the displacement of the holding tool by the linear actuator. The end effector includes resilient members each rigidly affixed to two adjacent holding tools and positioned in a space providing a mutual distance between opposing faces of the adjacent holding tools, where each holding tool is connected to—adjacent holding tools—by the resilient members. The resilient members are configured to non-permanently deform in the space when adjacent holding tools are displaced relative to each other along displacement axes.
B29C 70/30 - Façonnage par empilage, c.-à-d. application de fibres, de bandes ou de feuilles larges sur un moule, un gabarit ou un noyauFaçonnage par pistolage, c.-à-d. pulvérisation de fibres sur un moule, un gabarit ou un noyau
B29C 70/54 - Parties constitutives, détails ou accessoiresOpérations auxiliaires
B65H 3/08 - Enlèvement des articles des piles en utilisant la force pneumatique
B65H 5/14 - Détails des pincesMécanismes de déclenchement de celles-ci
The present invention relates to a method of producing a solar cell comprising a metal oxide layer on a substrate, and a solar cell comprising such metal oxide layer.
The present invention relates to a selective targeting agent, which is capable of binding MFAP4 and inhibiting MFAP4-integrin interaction for use in the prevention, alleviation and/or treatment of fibrosis. The invention further comprises compositions comprising said selective targeting agents.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
The present invention relates to a selective targeting agent, which is capable of binding MFAP4 and inhibiting MFAP4-integrin interaction for use in the prevention, alleviation and/or treatment of fibrosis. The invention further comprises compositions comprising said selective targeting agents.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
The present invention relates to compositions comprising a P-gp inducer, for topical use in preventing one or more side effects of chemotherapeutics, which chemotherapeutics are transported out of cells by P-gp. Especially chemotherapy-induced peripheral neuropathy (CIPN) is a relevant side effect to treat/avoid, since CIPN may be a dose limiting side effect of chemotherapy. The invention also relates to kits and to cancer treatment of a subgroup of patients, which subgroup has been topically pretreated with a P-gp inducer.
A61K 31/337 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à quatre chaînons, p. ex. taxol
A61K 31/475 - QuinoléinesIsoquinoléines ayant un cycle indole, p. ex. yohimbine, réserpine, strychnine, vinblastine
A61P 17/14 - Médicaments pour le traitement des troubles dermatologiques pour le traitement de la calvitie ou de l'alopécie
A61P 25/02 - Médicaments pour le traitement des troubles du système nerveux des neuropathies périphériques
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 31/57 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
The present invention relates to the use of a composition comprising tannins, preferably tannic acid, and fluoride for mitigating ammonia, methane and/or odor production and emissions. The invention also relates uses of such compositions.
C05G 3/90 - Mélanges d'un ou plusieurs engrais avec des additifs n'ayant pas une activité spécifique d'engrais pour influer sur la nitrification des composés d’ammonium ou de l’urée dans le sol
C05F 3/00 - Engrais fabriqués à partir des excréments humains ou animaux, y compris le fumier
C05G 5/27 - Dispersions, p. ex. suspensions, émulsions
C11D 3/00 - Autres composés entrant dans les compositions détergentes couvertes par le groupe
C11D 3/382 - Produits végétaux, p. ex. farine de soja, farine de bois, sciure de bois
C11D 3/04 - Composés inorganiques solubles dans l'eau
A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof.
The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof.
A dispenser unit (1) for dispensing biological material, e.g. larvae or insects etc. The dispenser unit has a rotary arrangement (2) with a drive shaft (3) and a plurality of protruding vanes (4) positioned inside a housing (10) for encasing the rotary arrangement to form chambers (5) for containing biological material between respective neighbouring vanes and an inner wall (11) of the housing. A track (6) on the housing serves to engage with each vane or movable element to control the volume of the chamber between an inlet opening (20) in a top part of the housing and an outlet opening (21) in a bottom part of the housing. This allows the biological material to be received in the chambers at the inlet opening (20) and dispensed from the chambers (5) at the outlet opening (21) during rotation of the rotary arrangement. The dispensing unit is designed to provide for an expanding chamber volume as the chambers are being rotated from the inlet opening to the outlet opening. The dispenser unit has proven to provide a low mortality e.g. for dispensing living larvae. It can be transported by a drone or the like to spread biological material over a large area.
B64U 101/60 - Véhicules aériens sans pilote spécialement adaptés à des utilisations ou à des applications spécifiques au transport de passagersVéhicules aériens sans pilote spécialement adaptés à des utilisations ou à des applications spécifiques au transport de marchandises autres que des armes
44.
RAMAN COMPUTED TOMOGRAPHY (RAMAN-CT) SYSTEM AND METHOD
The invention relates to an optical tomography scanning system (1) for 3D imaging of an object (100), for example an experimental rodent or a patient, using Raman scattered light from the object. A laser (10) and an optical configuration (20) for fixating the object and arranged for rotation (Θ) is provided, and an optical receiving part (30) receives Raman scattered light. The optical receiving part has a detector array (35) for receiving the Raman scattered light in two spatial dimensions (X, Z), and optical guide means (37) convey Raman scattered light to a spectrometer (38), where multiple spectra are recorded for the two spatial dimensions for each relative rotational position (Θ) of the object. A 3D image reconstruction of the object based on the multiple spectra at a plurality of relative rotational positions (Θ) of the object enables 3D tomographic imaging of the object, such as an experimental rat.
The invention relates to process for manufacturing a thin and stable copper film on a porous aluminum oxide (PAO) film on an aluminum alloy substrate. Initially, anodization of the aluminum alloy substrate results in a regularly ordered PAO film; and subsequently there is electrodeposited copper on this PAO/aluminum substrate, the electrodepositing comprises the use of direct current (DC), preferably 10-15 V, so as to deposit metallic copper both: 1) in the open pores of the regularly ordered PAO film, and 2) on the top of the regularly ordered PAO film, so as to form a copper film on top of the PAO film. The anodization is performed so as to improve the adhesion and electrochemical corrosion stability i.e. with no, or little, galvanic corrosion of the electrodeposited copper on the PAO/aluminum substrate. The copper coverage is substantially continuous on the PAO/aluminum substrate.
The present disclosure relates to a switch-mode DC-DC power converter comprising at least two power ports comprising an input port and an output port, wherein the switch-mode DC-DC power converter comprises a hard-switching circuit comprising a plurality of semiconducting devices including at least a first switching element. The hard-switching circuit is configured to receive a DC voltage source at an input side and to provide a substantially rectified output at an output side. The switch-mode DC-DC power converter further comprises a first capacitance, a first inductance and a soft-switching circuit. The first capacitance is coupled in parallel across one of the at least two power ports at one side of the hard-switching circuit whereas the first inductance is coupled in series with another of the at least two power ports and the hard-switching circuit at a second side of the hard-switching circuit opposite the first capacitance. The soft-switching circuit comprises a second capacitance, a second inductance, a first rectifying element and a controlled discharger, such as a voltage regulating element. The second inductance is coupled to the first capacitance and to at least one of the plurality of semiconducting devices. The first rectifying element is coupled to the second inductance and the second capacitance to charge the second capacitance by forward biasing the first rectifying element based on a voltage being induced across the second inductance in response to the hard-switching circuit transitioning from one mode to another mode. The controlled discharger is coupled to the second capacitance to then reduce a voltage across the second capacitance towards a voltage level substantially above the voltage across the first capacitance.
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
The invention relates to a drone (1) for dispensing biological material (11), such as live beneficial animals. The drone comprises a drone body (2) and propulsion means (4) for providing the propulsion of the drone during use. It further comprises a container (5) for storage of biological material to be dispensed, a dispenser unit (7) for dispensing the biological material, and a possibly a guide (6) for transferring the biological material from the container to the dispenser unit. The guide is arranged inclined with respect to vertical. In alternative embodiments, the container is inclined and is arranged to extend all the way to the dispenser unit. The drone may further be provided with a blower (12) arranged to blow the biological material away from the drone during the dispensing.
The present invention concerns a robotic sampling apparatus for obtaining a biological sample from a patient, comprising a preparation compartment 5 comprising a plurality of storage areas accommodating individual test kit objects and a transfer arrangement for accommodating and repositioning at least one test kit object, and a first handling system for collecting at least one test kit object from at least one of said storage areas and positioning said at least one test kit object in said transfer arrangement; a sanitation compartment, which is adapted to receiving the at least one test kit object on the transfer arrangement, and wherein said sanitation compartment comprises a second handling system for picking a test kit object for obtaining the biological sample from the patient, an opening for a patient area for providing the patient in a predetermined position which is accessible to the second handling system for moving said test kit object from an initial position to an active position in which the biological sample can be obtained from the patient; and a control system provided for governing at least the first handling system, the movement of the transfer arrangement and the second handling system for performing of the robotic sampling apparatus when obtaining the biological sample from a patient.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
A device for obtaining a sample from a subject. The device has a base part (10) with a base canal (13) extending into the base part (10), sensor means (12) being adapted to detect an element entering the base canal, a holding part (100) with a coupling end configured to interlock with the base part (10), a receiving end, and a holding canal (101) for holding an associated sample obtaining element (5). The device is arranged for holding an associated sample obtaining element (5), having a sample end (6) which protrudes from the receiving end of the holding part (100) when the associated sample obtaining element is inserted into the holding canal. The base part has fixation means configured to provide releasable fixation in an axial direction, to the associated sample obtaining element, the fixation means fixating the associated sample obtaining element with a force F. The fixation means has safety means configured to release fixation of the associated sample obtaining element (5), if a force Q exceeding F, is applied to the sample end of the associated sample obtaining element, and the device is adapted to provide a signal to the associated device if the safety means or the sensor means are activated by the associated sample obtaining element (5), due to an external force, provided to the sample end (6) of the associated sample element in a longitudinal or substantially longitudinal direction.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
50.
A ROBOT SYSTEM ARRANGED FOR AUTONOMOUSLY OBTAINING BIOLOGICAL SURFACE SAMPLES FROM A PATIENT
The invention relates to a method for controlling an apparatus (100) for taking biological surface samples of a test surface of a patient, the apparatus comprise a motorized multi-degree of freedom motion system (101) which is connectable with a tool holder (102), wherein the tool holder is configured to hold a sample probe (103) for obtaining the biological sample, a vision system arranged to provide image data, and a control system for controlling the motorized multi- degree of freedom motion system based on the image data, the method comprises setting the sample probe in an initial position, obtaining an image of the test surface during an identification period, determining probe motion data based on the image data of the image, controlling the motorized multi-degree of freedom motion system to move the sample probe until contact with the test surface is determined, and controlling the motorized multi-degree of freedom motion system to move the sample probe while maintaining contact with the test surface based on the probe motion data.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 17/24 - Instruments, dispositifs ou procédés chirurgicaux pour la cavité buccale, le larynx, les conduits des bronches ou le nezGrattoirs pour la langue
A61B 34/32 - Robots chirurgicaux opérant de façon autonome
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
The present invention relates to a method for coating medical implants. In particular, the present invention relates to coating compositions comprising PDLLA, VEGF, chloroform, an organic solvent different from chloroform, preferably a carrier such as BSA and water for coating medical implants. Such coated medical implants show improved bone regeneration and ingrowth after implantation.
Compounds of formula (1) comprising a pleuromutilin backbone with a triazole based side-group at C22 are provided. The compounds can be used for treatment of bacterial infections and fungal infections. Importantly, infections caused by multidrug-resistant bacteria, such as methicillin-resistant staphylococcus aureus (MRSA) may be treated effectively.
C07D 249/06 - Triazoles-1, 2, 3Triazoles-1, 2, 3 hydrogénés avec des radicaux aryle liés directement aux atomes du cycle
C07D 403/10 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles aromatiques
C07D 473/02 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6
53.
ANTIBACTERIAL AND ANTIFUNGAL PLEUROMUTILIN CONJUGATES
Compounds of formula (1) comprising a pleuromutilin backbone with a triazole based side-group at C22 are provided. The compounds can be used for treatment of bacterial infections and fungal infections. Importantly, infections caused by multidrug-resistant bacteria, such as methicillin-resistant staphylococcus aureus (MRSA) may be treated effectively.
C07D 249/06 - Triazoles-1, 2, 3Triazoles-1, 2, 3 hydrogénés avec des radicaux aryle liés directement aux atomes du cycle
C07D 403/10 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles aromatiques
C07D 473/02 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6
This invention relates to a device for capturing microorganisms from an environment in which the device is placed during use, the device comprising at least one growth compartment comprising at least one entry opening, said at least one entry opening being exposed at a surface of the device for microorganisms to enter the growth compartment from the environment; at least one nutrition compartment separate from said at least one growth compartment; and at least one release opening fluidly connecting said at least one growth compartment with said at least one nutrition compartment. The invention further relates to a method of capturing the microorganisms using the device.
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
55.
DEVICE FOR CAPTURING MICROORGANISMS FROM THE ENVIRONMENT
This invention relates to a device for capturing microorganisms from an environment in which the device is placed during use, the device comprising at least one growth compartment comprising at least one entry opening, said at least one entry opening being exposed at a surface of the device for microorganisms to enter the growth compartment from the environment; at least one nutrition compartment separate from said at least one growth compartment; and at least one release opening fluidly connecting said at least one growth compartment with said at least one nutrition compartment. The invention further relates to a method of capturing the microorganisms using the device.
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
56.
POWER MODULE WITH AN INTEGRATED ALUMINIUM SNUBBER CAPACITOR
FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (Allemagne)
Inventeur(s)
Ebel, Thomas
Schletz, Andreas
Abrégé
This invention concerns a power module comprising a power device, a baseplate, circuit carrier, and a flat stacked aluminium electrolytic snubber capacitor comprising a layered structure of a cathode layer, a separator layer, comprising paper and an electrolyte and an anode layer, comprising an aluminium material with an aluminium oxide dielectric, wherein the circuit carrier are mounted on the baseplate, the power device and snubber capacitor are placed on the circuit carrier within the power module and electrically connected to the circuit carrier, the circuit carrier being configured for providing an electrical connection between the power device and the snubber capacitor.
H01G 9/035 - Électrolytes liquides, p. ex. matériaux d'imprégnation
H01G 9/14 - Combinaisons structurales pour modifier ou compenser les caractéristiques de condensateurs
H01G 9/28 - Combinaisons structurales de condensateurs électrolytiques, de redresseurs électrolytiques, de détecteurs électrolytiques, de dispositifs de commutation électrolytiques, avec d'autres composants électriques non couverts par la présente sous-classe
H01G 2/08 - Dispositions de réfrigérationDispositions de chauffageDispositions de ventilation
H01G 9/00 - Condensateurs électrolytiques, redresseurs électrolytiques, détecteurs électrolytiques, dispositifs de commutation électrolytiques, dispositifs électrolytiques photosensibles ou sensibles à la températureProcédés pour leur fabrication
H01G 9/045 - Électrodes caractérisées par le matériau à base d'aluminium
H01G 9/012 - Bornes spécialement adaptées pour les condensateurs à solides
The present invention relates to a method of recovering iridium in the form of iridium solutions, metal, oxides or salts from a body, such as a spent catalyst, comprising iridum oxides.
Escherichia coli (ETEC) that are immunogenic. In particular, the present invention relates to compositions or vaccines comprising the polypeptides and their application in immunization, vaccination, treatment and diagnosis of ETEC.
The present invention relates to a method and a system for tracking the motion of a blade of a wind turbine. One embodiment relates to a blade motion tracking system for installation on a wind turbine blade, where the wind turbine blade comprises a blade root and a blade tip. The system comprises at least one light module comprising at least a first light source, preferably adapted to emit light in the direction of the blade root. An optical measuring device is provided, preferably located at the blade root, adapted to receive light emitted from the first light source(s). The optical measuring device is preferably a position sensitive detector identifying the position of the first light source relative to the position sensitive detector. A single light source located at the tip of the blade, close to the tip of the or towards the tip of the blade, is sufficient to measure deflection of the blade. Advantageously the first light source is modulated with a predefined modulation frequency such that light from the first light source can be distinguished from ambient light and thereby minimize the influence of the ambient light conditions during detection.
The present invention relates to a method and a system for tracking the motion of a blade of a wind turbine. One embodiment relates to a blade motion tracking system for installation on a wind turbine blade, where the wind turbine blade comprises a blade root and a blade tip. The system comprises at least one light module comprising at least a first light source, preferably adapted to emit light in the direction of the blade root. An optical measuring device is provided, preferably located at the blade root, adapted to receive light emitted from the first light source(s). The optical measuring device is preferably a position sensitive detector identifying the position of the first light source relative to the position sensitive detector. A single light source located at the tip of the blade, close to the tip of the or towards the tip of the blade, is sufficient to measure deflection of the blade. Advantageously the first light source is modulated with a predefined modulation frequency such that light from the first light source can be distinguished from ambient light and thereby minimize the influence of the ambient light conditions during detection.
The present disclosure relates to an end effector (2) for handling of a sheet (8) of flexible material, such as a carbon fiber mat, to be applied onto a layup surface (19). The end effector (2) comprises a support frame (3) and a plurality of manipulator assemblies (9, 9a-9c), each attached to the support frame (3) by a support mount (13). The manipulator assemblies (9, 9a-9c) comprise a holding tool (12, 12a-12c) having a lifting surface (17), where the holding tool is configured for lifting a sheet (8). Moreover the manipulator assemblies (9, 9a-9c) comprise a linear actuator (10, 10a-10c), and the holding tool (12, 12a-12c) is connected to the linear actuator by a multiaxial joint (14). A drive (23) is configured for providing the displacement of the holding tool (12, 12a-12c) by means of the linear actuator (10, 10a-10c). The end effector (2) further comprises a plurality of resilient members (15, 15a, 15b) each rigidly affixed to two adjacent holding tools (12a-12c) and positioned in a space (25) providing a mutual distance (D1) between opposing faces (24) of the adjacent holding tools (12a-12c), where each holding tool (12, 12a-12c) is connected to at least two adjacent holding tools (12a-12c) by means of the resilient members (15, 15a, 15b). The resilient members (15, 15a, 15b) are configured to non-permanently deform in the space (25) when adjacent holding tools (12a-12c) are displaced relative to each other along displacement axes (AX1, AX2).
A powerline engagement system (300) for mounting on a drone (200) or configured to form part of a drone to be engaged with a powerline (100) is disclosed. The system comprises a split core gripper (301), which may be a split core current transformer, having a first part (302) and at least one second part (303) movably connected to the first part. The at least one second part is movable, by use of an actuator (308), between a closed configuration in which a closed circuit is formed, and an open configuration in which there is an upwardly facing gap (305) for letting a powerline pass there through to allow for the engagement. During faulty operation conditions, the at least one second part can be automatically moved from the closed configuration to the open configuration in order to disengage the powerline engagement system from the powerline. Thus, the drone can fall down by gravity so that there is no need for a person to come up to the powerline to release it.
G01R 31/08 - Localisation de défauts dans les câbles, les lignes de transmission ou les réseaux
H02G 1/02 - Méthodes ou appareils spécialement adaptés à l'installation, entretien, réparation, ou démontage des câbles ou lignes électriques pour lignes ou câbles aériens
G01R 31/50 - Test d’appareils, de lignes, de câbles ou de composants électriques pour y déceler la présence de courts-circuits, de continuité, de fuites de courant ou de connexions incorrectes de lignes
63.
P-GP INDUCERS AS PROTECTORS AGAINST CHEMOTHERAPY-INDUCED SIDE EFFECTS, SUCH AS PERIPHERAL NEUROPATHY (CIPN) AND HAIR LOSS
The present invention relates to compositions comprising a P-gp inducer, for topical use in preventing one or more side effects of chemotherapeutics, which chemotherapeutics are transported out of cells by P-gp. Especially chemotherapy-induced peripheral neuropathy (CIPN) is a relevant side effect to treat/avoid, since CIPN may be a dose limiting side effect of chemotherapy. The invention also relates to kits and to cancer treatment of a subgroup of patients, which subgroup has been topically pretreated with a P-gp inducer.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/337 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à quatre chaînons, p. ex. taxol
A61K 31/475 - QuinoléinesIsoquinoléines ayant un cycle indole, p. ex. yohimbine, réserpine, strychnine, vinblastine
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61P 17/14 - Médicaments pour le traitement des troubles dermatologiques pour le traitement de la calvitie ou de l'alopécie
A61P 25/02 - Médicaments pour le traitement des troubles du système nerveux des neuropathies périphériques
The present invention relates to an isolated CD31+ cell derived from adipose-derived regenerative cells (ADRC's), for use as a medicament. The invention also relates to compositions comprising such cells. In addition, the invention relates to methods for screening for the regenerative capacity of a population of adipose-derived regenerative cells (ADRC's).
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
A61P 15/10 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour l'impuissance
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
The invention relates to an optical tomography scanning system (1) for 3D imaging of an object (100), for example an experimental rodent or a patient, using Raman scattered light from the object. A laser (10) and an optical configuration (20) for fixating the object and arranged for rotation (Θ) is provided, and an optical receiving part (30) receives Raman scattered light. The optical receiving part has a detector array (35) for receiving the Raman scattered light in two spatial dimensions (X, Z), and optical guide means (37) convey Raman scattered light to a spectrometer (38), where multiple spectra are recorded for the two spatial dimensions for each relative rotational position (Θ) of the object. A 3D image reconstruction of the object based on the multiple spectra at a plurality of relative rotational positions (Θ) of the object enables 3D tomographic imaging of the object, such as an experimental rat.
The present invention relates to the use of a composition comprising tannins, preferably tannic acid, and fluoride for mitigating ammonia, methane and/or odor production and emissions. The invention also relates uses of such compositions.
C05G 3/90 - Mélanges d'un ou plusieurs engrais avec des additifs n'ayant pas une activité spécifique d'engrais pour influer sur la nitrification des composés d’ammonium ou de l’urée dans le sol
C05G 5/30 - Engrais caractérisés par leur forme en couches ou enrobés, p. ex. enrobages anti-poussière
The present invention relates to the use of a composition comprising tannins, preferably tannic acid, and fluoride for mitigating ammonia, methane and/or odor production and emissions. The invention also relates uses of such compositions.
C05G 5/30 - Engrais caractérisés par leur forme en couches ou enrobés, p. ex. enrobages anti-poussière
C05G 3/90 - Mélanges d'un ou plusieurs engrais avec des additifs n'ayant pas une activité spécifique d'engrais pour influer sur la nitrification des composés d’ammonium ou de l’urée dans le sol
A dispenser unit (1) for dispensing biological material, e.g. larvae or insects etc. The dispenser unit has a rotary arrangement (2) with a drive shaft (3) and a plurality of protruding vanes (4) positioned inside a housing (10) for encasing the rotary arrangement to form chambers (5) for containing biological material between respective neighbouring vanes and an inner wall (11) of the housing. A track (6) on the housing serves to engage with each vane or movable element to control the volume of the chamber between an inlet opening (20) in a top part of the housing and an outlet opening (21) in a bottom part of the housing. This allows the biological material to be received in the chambers at the inlet opening (20) and dispensed from the chambers (5) at the outlet opening (21) during rotation of the rotary arrangement. The dispensing unit is designed to provide for an expanding chamber volume as the chambers are being rotated from the inlet opening to the outlet opening. The dispenser unit has proven to provide a low mortality e.g. for dispensing living larvae. It can be transported by a drone or the like to spread biological material over a large area.
B64C 39/02 - Aéronefs non prévus ailleurs caractérisés par un emploi spécial
B64D 1/16 - Largage en vol d'une matière poudreuse, liquide ou gazeuse, p. ex. pour la lutte contre l'incendie
B64D 1/18 - Largage en vol d'une matière poudreuse, liquide ou gazeuse, p. ex. pour la lutte contre l'incendie par pulvérisation, p. ex. d'insecticides
69.
Dual-mode endoscopic capsule with image processing capabilities
An endoscopic capsule comprising first and second imaging systems, wherein the first imaging system is arranged for obtaining images at a broader spectral range than the second imaging system, the capsule comprising a processor, the capsule arranged for operating in any one of a first mode wherein a frame rate of the first imaging system exceeds a frame rate of the second imaging system, and a second mode wherein the frame rate of the second imaging system exceeds the frame rate of the second imaging system in the first mode, wherein the processor in the first mode is arranged for accessing one or more images from the first imaging system, detecting if there is a polyp in said one or more images, and switching from the first mode to the second mode if a polyp is detected in the one or more images from the first imaging system.
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
70.
Bacitracin and/or daptomycin combined with cannabidiol for treatment of bacterial infections
The present invention relates to compositions comprising Cannabidiol (CBD) or pharmaceutically acceptable salts thereof, and bacitracin or pharmaceutically acceptable salts thereof and/or daptomycin or pharmaceutically acceptable salts thereof. The compositions show a synergistic effect in the inhibition of growth of Gram-positive bacteria. Thus, the compositions according to the invention may e.g. find use as medicaments in the treatment of Gram-positive bacterial infections.
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
The present invention relates to a method for coating medical implants. In particular, the present invention relates to coating compositions comprising PDLLA, VEGF, chloroform, an organic solvent different from chloroform, preferably a carrier such as BSA and water for coating medical implants. Such coated medical implants show improved bone regeneration and ingrowth after implantation.
A sorting system for sorting objects, such as nuts and bolts. The system comprises a container with assorted objects and/or a container with substantially identical objects to be sorted, a robotic manipulator, such as a robotic arm, within reach of the container. A scoop (10) is mounted on the flange of the robotic arm, for scooping up objects from the container. The scoop is designed with an inlet (11), a funnel (14) at the inlet and a groove (17), wherein the funnel is designed for feeding objects into the groove and the groove is specifically designed for sorting through objects and aligning specific objects within the groove. As some objects do not settle within the groove directly from the funnel, the robotic arm can perform translational and/or rotational movements, shuffling the objects within the scoop, settling and aligning additional objects within the scoop. The objects, now aligned within the groove, are oriented so as to be grasped by a robotic gripper for sorting.
B07B 13/04 - Classement ou triage des matériaux solides par voie sèche non prévu ailleursTriage autrement que par des dispositifs commandés indirectement selon la taille
B65G 47/24 - Dispositifs pour influencer la position relative ou l'orientation des objets pendant le transport par transporteurs présentant les objets selon un orientement donné
B65G 47/52 - Dispositifs pour transférer objets ou matériaux entre transporteurs, p. ex. pour décharger ou alimenter
73.
Methods for obtaining natural colourants from plant based materials
The present invention relates to methods for obtaining natural colorants from materials of plant origin. The method comprises a mixing step, a co-pigmentation step, an enzymatic hydrolysis step and various filtration steps carried out under specific conditions.
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
C12P 19/14 - Préparation de composés contenant des radicaux saccharide préparés par action d'une carbohydrase, p. ex. par action de l'alpha-amylase
The present invention relates to a method for dissolving, recovering, extracting or separating precious metals. Efficient recovery of precious metals from industrial spent catalysts through electrochemical means using dilute acid/acid-free electrolytes is of significant importance from both the industrial and the environmental points of view. Owing to their large surface-to-volume ratio, fast dissolution through electrochemical potential cycling is possible. However, redeposition of the dissolved metal species on larger particles reduces the process efficiency significantly. In one aspect of the present invention, faster dissolution can be attained by inhibition of particle growth using surface switching species (SSS) functioning to selectively block and expose the metal surface to facilitate dissolution and inhibit redeposition, respectively. In another aspect of the present invention, the redeposition may be minimized by removing the dissolved Pt species redepositiong them (in metal form) electrochemically on a second working electrode.
Escherichia coli (ETEC) that are immunogenic. In particular, the present invention relates to compositions or vaccines comprising the polypeptides and their application in immunization, vaccination, treatment and diagnosis of ETEC.
The present invention relates to an isolated CD31+ cell derived from adipose-derived regenerative cells (ADRC's), for use as a medicament. The invention also relates to compositions comprising such cells. In addition, the invention relates to methods for screening for the regenerative capacity of a population of adipose-derived regenerative cells (ADRC's).
The present invention relates to an isolated CD31+ cell derived from adipose-derived regenerative cells (ADRC's), for use as a medicament. The invention also relates to compositions comprising such cells. In addition, the invention relates to methods for screening for the regenerative capacity of a population of adipose-derived regenerative cells (ADRC's).
There is presented an endoscopic capsule (100) comprising a first imaging system (101, 110, 112) and a second imaging system (102, 110, 112), wherein the first imaging system is arranged for obtaining images at a broader spectral range than the second imaging system, the endoscopic capsule further comprising a processor (114), wherein the endoscopic capsule is arranged for operating in any one of a first mode wherein a frame rate of the first imaging system is higher than a frame rate of the second imaging system, and a second mode wherein the frame rate of the second imaging system is higher than the frame rate of the second imaging system in the first mode, wherein the processor (114) in the first mode is arranged for accessing one or more images from the first imaging system, detecting if there is a polyp (104) in the one or more images from the first imaging system, and switching from the first mode to the second mode if a (polyp 104) is detected in the one or more images from the first imaging system.
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
79.
DUAL-MODE ENDOSCOPIC CAPSULE WITH IMAGE PROCESSING CAPABILITIES
There is presented an endoscopic capsule (100) comprising a first imaging system (101, 110, 112) and a second imaging system (102, 110, 112), wherein the first imaging system is arranged for obtaining images at a broader spectral range than the second imaging system, the endoscopic capsule further comprising a processor (114), wherein the endoscopic capsule is arranged for operating in any one of a first mode wherein a frame rate of the first imaging system is higher than a frame rate of the second imaging system, and a second mode wherein the frame rate of the second imaging system is higher than the frame rate of the second imaging system in the first mode, wherein the processor (114) in the first mode is arranged for accessing one or more images from the first imaging system, detecting if there is a polyp (104) in the one or more images from the first imaging system, and switching from the first mode to the second mode if a (polyp 104) is detected in the one or more images from the first imaging system.
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
The 5'-AMP-activated protein kinase AMPK functions as a master switch to maintain cellular and whole-body energy homeostasis and abnormal activity profiles of AMPK may cause pathological disorders. The present invention relates to a series of compounds (I) based on a pyrrolo[2,3-c]pyridine and a thieno[2,3- c]pyridine scaffold as AMPK inhibitors. In particular, the present invention relates to the synthesis of such compounds and the medical use of such compounds.
A61K 31/4365 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique ayant le soufre comme hétéro-atome du cycle, p. ex. ticlopidine
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
The present invention relates to antibodies, including humanized antibodies that bind human Microfibrillar-associated protein 4 (MFAP4). The invention also relates to uses of such antibodies.
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
82.
PERSISTENT LUMINESCENT MATERIALS AND METHOD OF PRODUCING THEREOF
C09K 9/00 - Substances devenant sombres, c.-à-d. substances pour lesquelles la gamme de longueurs d'onde absorbées est modifiée par excitation avec une énergie sous une forme quelconque
C01B 39/50 - Zéolites dans lesquelles des bases ou des sels inorganiques occluent les canaux dans la charpente du réseau, p. ex. sodalite, cancrinite, noséane, haüynite
C09K 11/56 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du soufre
C09K 11/59 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du silicium
C09K 11/64 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant de l'aluminium
The present invention relates to antibodies, including humanized antibodies that bind human Microfibrillar-associated protein 4 (MFAP4). The invention also relates to uses of such antibodies.
C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
84.
DESIGN OF ROBOT GRIPPERS AND FIXTURES FOR ROBOTIC MANUFACTURING
The invention relates to a method for designing grippers and fixtures for handling objects in robotic manufacturing and pick-and-place tasks. To achieve this a method for determining a shape of the holding or support surface of the gripper or fixture is presented. This method includes steps of determining an initial shape of the support surface based on an outer shape of the object, applying a shaping function to different locations of the initial shape, determining modified shape points at locations of the initial shape by comparing the applied shaping function with the initial shape. If the application of the shaping function results in an extension of the initial shape G(xi,yj) at the neighbour location (xi, yj) this extension forms part of a modified support surface for the gripper or fixture. A method for determining an optimum shape of the support surface with respect to optimization conditions is also presented.
B25J 19/00 - Accessoires adaptés aux manipulateurs, p. ex. pour contrôler, pour observerDispositifs de sécurité combinés avec les manipulateurs ou spécialement conçus pour être utilisés en association avec ces manipulateurs
The present invention relates to a method for recovery of high purity calcium phosphate from waste waters. In particular, the present invention relates to precipitation of dibasic calcium phosphate dihydrate (DCPD) or hydroxyapatite (HAp). The DCPD and HAp obtained by the method complies with the European Commission Regulation No 231/2012 laying down specifications for food additives. Thus, the high purity calcium phosphate obtained by the method of the invention may be suitable for use in the food industry.
The present invention relates to compositions comprising Cannabidiol (CBD) or pharmaceutically acceptable salts thereof, and bacitracin or pharmaceutically acceptable salts thereof and/or daptomycin or pharmaceutically acceptable salts thereof. The compositions show a synergistic effect in the inhibition of growth of Gram-positive bacteria. Thus, the compositions according to the invention may e.g. find use as medicaments in the treatment of Gram-positive bacterial infections.
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
The present invention relates to compositions comprising Cannabidiol (CBD) or pharmaceutically acceptable salts thereof, and bacitracin or pharmaceutically acceptable salts thereof and/or daptomycin or pharmaceutically acceptable salts thereof. The compositions show a synergistic effect in the inhibition of growth of Gram-positive bacteria. Thus, the compositions according to the invention may e.g. find use as medicaments in the treatment of Gram-positive bacterial infections.
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
The present invention relates to a compression garment, preferably a compression stocking, for providing neuromuscular electrical stimulation (NMES), the compression garment comprises at least two integrated electrode pads enabling NMES, wherein the integrated electrode pads comprise silicone polymers the silicone polymer further comprising graphene, the electrode pads being adapted to be in contact with the skin when in use.
The present invention relates to moulding or casting processes for producing solid objects. The process involves a suspension which comprising a liquid non-aqueous substance and a material such as a ceramic. The suspension is liquid at elevated temperatures (e.g. above 40°C) but solid at lower temperatures (e.g. below 40°C). The solidified suspension may find direct use as a medical implant. In a preferred embodiment, the mould or cast is dissolvable in a solvent, which is a non-solvent for the solidified suspension, thereby providing an efficient and fast process for providing e.g. medical implants. The invention also relates to objects obtainable/obtained by such process and uses of such objects.
C04B 28/34 - Compositions pour mortiers, béton ou pierre artificielle, contenant des liants inorganiques ou contenant le produit de réaction d'un liant inorganique et d'un liant organique, p. ex. contenant des ciments de polycarboxylates contenant des liants phosphate froids
A61L 27/40 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
The present invention relates to removal of hemoglobin from a sample. In particular the present invention relates to a method in which a protein with specificity towards hemoglobin and/or the complex of hemoglobin with haptoglobin is immobilized on a solid support and utilized to remove hemoglobin from a sample comprising hemoglobin, such as a hemolysed sample obtained from a subject.
G01N 33/72 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir les pigments du sang, p. ex. l'hémoglobine, la bilirubine
91.
METHODS FOR OBTAINING NATURAL COLOURANTS FROM PLANT BASED MATERIALS
The present invention relates to methods for obtaining natural colorants from materials of plant origin. The method comprises a mixing step, a co-pigmentation step, an enzymatic hydrolysis step and various filtration steps carried out under specific conditions.
The invention relates to a method for determining deformation values of muscles, particularly skeletal muscles. According to the method, an image sequence of ultrasonic images of the muscle is obtained during a period where the patient performs a loaded action which causes the muscle to contract. During this period, the patient is guided to exert a predetermined force on an exercise device. The actually exerted force is measured simultaneously with the ultrasonic image sequence. Deformation values are determined based on the recorded image sequence. The invention also provides an apparatus for performing the method.
A63B 21/00 - Appareils de gymnastique pour développer ou fortifier les muscles ou les articulations du corps en surmontant des résistances, avec ou sans dispositifs de mesure
There is presented an aorto-iliac preservation stent graft (100) for treatment of aorto-iliac aneurysms, said aorto-iliac preservation stent graft comprising a main body (104) comprising a bifurcation, and a first leg (101) with with a cross-sectional area increasing in a direction away from the main body (104), and wherein at least a distal end portion of the first leg comprises a primary interior lumen (116) suitable for connection to a leg extension (218) and a secondary interior lumen (120) suitable for connection to a stent graft extension (222), said aorto-iliac preservation stent graft (100) further comprising a second leg (102) wherein a first leg length (124) is larger than a second leg length (126), and wherein graft material of the main body (104), the first leg (101) and the second leg (102) form a monolithic unit of biocompatible graft material.
In one aspect, the present invention pertains to a system for increasing the methane content of biogas (biogas upgrading). In another aspect, the invention relates to a method for increasing the methane content of biogas.
The present invention relates to mowers (1) having a safety system (7) to prevent obstacles (10), such as animals, located in the field from being hit by cutters (4) of the mower(1). The safety system (7) comprises a control unit(8) and at least one detector (9) to detect the obstacle (10) and then provide a warning signal (11) to the control unit(8),when the obstacle (10) is detected. The control unit (8) provides a separation signal (13) to at least one safety device (12) in response to receiving the warning signal (11), and the at least one safety device (12) causes separation between the obstacle (10) and the at least one cutter (4) in response to receiving the separation signal (13). The safety device (12) may be at least one shield (17) which is movable between a retracted position and a protecting position in which it extends in front of the at least one cutter (4) to prevent contact between the at least one cutter (4) and the obstacle(10).
A01D 34/86 - FaucheusesAppareils de fauchage des moissonneuses spécialement adaptés à des usages particuliers pour une utilisation sur un terrain en pente, p. ex. sur un talus
A01D 75/18 - Dispositifs de sécurité pour certaines parties des machines
96.
Assembly for assessing drug permeability with adjustable biomimetic properties
There is provided an assembly and process for its preparation for predicting the permeability of chemical compounds, comprising a donor compartment for adding a composition comprising the compound; a barrier based on a support and a phospholipid layer adhering to the support; and an acceptor compartment for accepting the compound upon permeation of the barrier.
There is provided SSOs targeting the region of HRAS, KRAS, and HRAS exon 2 that harbors the activating mutations and which harbors ESE activity. Moreover, there is provided SSOs targeting the 3′- and 5′-splice sites. The SSOs targeting the 5′ splice site sequence of HRAS exon 2, the 3′ splice site sequence of KRAS exon 2 and the 3′ splice site sequence of NRAS exon 2, as well as SSOs that targets ESEs in a conserved part of exon 2 in the HRAS, KRAS and NRAS exon 2 sequences can induce complete or nearly complete exon 2 skipping in cancer cell lines. This results in growth and proliferation inhibition and concomitantly in death of cancer cells. Therefore this invention is directed towards treatment of cancerous diseases and other conditions where RAS signaling is involved.
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
The present invention relates to a bispecific antibody targeting CD73. In particular, the present invention relates to a bispecific antibody targeting different epitopes on CD73 or a bispecific antibody targeting an epitope on CD73 and an epitope on a different antigen.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A method is provided for treating or ameliorating a high-grade glioma in a patient, which method comprises intracerebral administering of a radioactive agent characterized by a short-range cytotoxic ionizing radiation by convection-enhanced delivery. Further, a radioactive agent characterized by a short-range cytotoxic ionizing radiation is provided for use in treating or ameliorating a high-grade glioma, where the agent is administered by intracerebral convection-enhanced delivery.
A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
A61K 51/00 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo
100.
GLYCOSYLATED YGHJ POLYPEPTIDES FROM ENTEROTOXIGENIC ESCHERICHIA COLI (ETEC)
The present invention relates to glycosylated YghJ polypeptides from or derived from enterotoxigenic Escherichia coli (ETEC) that are immunogenic. In particular, the present invention relates to compositions or vaccines comprising the polypeptides and their application in immunization, vaccination, treatment and diagnosis of ETEC.
