A prokaryote was genetically engineered to develop operationally simple, high-yield biosynthetic route for the production of farnesylated proteins. The recombinant organism was modified to express a target protein, a peptide sequence fused to the target protein at a C-terminus, and an alpha and a beta subunit of a prenyltrasferase. The prenyltrasferase may be farnesyltransferase or geranylgeranyl transferase, and the peptide sequence may comprise cysteine, two hydrophobic amino acids, and an amino acid having selectivity to farnesyltransferase or geranylgeranyl transferase.
C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
C12P 7/64 - GraissesHuilesCires de type esterAcides gras supérieurs, c.-à-d. ayant une chaîne continue d'au moins sept atomes de carbone liée à un groupe carboxyleHuiles ou graisses oxydées
A shape memory polymer scaffold for treatment of a fistula. The scaffold is formed from a shape memory polymer foam that can be triggered to expand from a compressed shape to an expanded shape in response to hydration and/or heating. The shape memory polymer foam includes an antibacterial component and a biodegradable component so that the scaffold addresses infective agents in the fistula and will degrade over time as the fistula heals. The foam may comprise poly(vinyl alcohol), starch, and a phenolic acid.
Methods and compositions are provided for oxidizing peptides and forming disulfide bonds. In some aspects, a rapid, green, and facile oxidation of peptides (e.g., cysteine containing peptides) is performed (e.g., to promote the formation of 1-3 or more disulfide bonds). In some aspects, methods are conducted in aqueous solutions, in air, utilizing a biocompatible corrin ring-containing compound (e.g., dicyanocobinamide). In some aspects, reaction times are under 1 hour and a simple one step removal of the catalyst can be performed.
A strategy for bacterial persister control using amphiphilic antibiotics that do not require active transport to penetrate bacterial membranes of persister cells. Persister cells have reduced drug efflux and accumulate more minocycline than normal cells, leading to effective killing of this dormant subpopulation upon wake-up. While dormancy is a well-known cause of antibiotic tolerance, it also provides an Achilles' heel for controlling persister cells by leveraging dormancy associated reduction of drug efflux.
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
A61K 31/343 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à cinq chaînons avec un oxygène comme seul hétéro-atome d'un cycle, p. ex. isosorbide condensés avec un carbocycle, p. ex. coumarane, bufaralol, béfunolol, clobenfurol, amiodarone
Exemplary methods, systems, apparatus, and computer programs are disclosed for an unmanned aerial system (UAS) inspection system that includes an unmanned aerial system and analysis system for exterior building envelopes and energy performance evaluation and simulation. The UAS can autonomously and systematically collect data for a building's exterior using a payload comprising (i) nondestructive testing (NDT) sensors configured for imaging (visible, infrared, or more) the building and (ii) one or more multi-spectral sensors (LiDAR, ultrasound, radar, or more). The acquired sensor data are provided to an analysis system comprising computer vision (CV) and signal processing modules configured to analyze the acquired data to i) identify building objects (doors, windows, rooftop units, and others) ii) characterize envelope properties (components, heat resistivity, or others) and 3) identify initial thermal anomalies (thermal bridges, physical defects, or infiltration/exfiltration) in a processing pipeline.
G01J 5/00 - Pyrométrie des radiations, p. ex. thermométrie infrarouge ou optique
G01J 5/10 - Pyrométrie des radiations, p. ex. thermométrie infrarouge ou optique en utilisant des détecteurs électriques de radiations
G05D 1/689 - Interaction avec des charges utiles ou des entités externes dirigeant des charges utiles vers des cibles fixes ou en mouvement
G05D 105/80 - Applications spécifiques des véhicules commandés pour la collecte d’informations, p. ex. recherche universitaire
G06T 7/33 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images utilisant des procédés basés sur les caractéristiques
G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
G06V 10/75 - Organisation de procédés de l’appariement, p. ex. comparaisons simultanées ou séquentielles des caractéristiques d’images ou de vidéosApproches-approximative-fine, p. ex. approches multi-échellesAppariement de motifs d’image ou de vidéoMesures de proximité dans les espaces de caractéristiques utilisant l’analyse de contexteSélection des dictionnaires
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
The Research Foundation for the State University of New York (USA)
SYRACUSE UNIVERSITY (USA)
Inventeur(s)
Kerr, William
Pedicone, Chiara
Chisolm, John
Dormann, Shawn
Abrégé
The present disclosure provides methods of using compositions that inhibit SII2-containing inositol 5′-phosphatases (SHIPs) for activating microglial cells, as well as methods for using such compositions for treatment or ameliorating of neurodegenerative disorders in a subject.
A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p. ex. cholane, cholestane, ergostérol, sitostérol
A61K 31/4045 - Indole-alkylaminesLeurs amides, p. ex. sérotonine, mélatonine
A61K 31/568 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en positions 10 et 13 par une chaîne ayant au moins un atome de carbone, p. ex. androstane, testostérone
A61K 31/5685 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en positions 10 et 13 par une chaîne ayant au moins un atome de carbone, p. ex. androstane, testostérone ayant un groupe oxo en position 17, p. ex. androstérone
A61K 31/57 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone
7.
MECHANOPHORE WITH FORCE TRIGGERED STEREOCHEMISTRY CONVERSION
A parallel diarylethene mechanophore with mirror symmetry may be converted to its anti-parallel stereoisomer of C2 symmetry under ultrasound-induced force field. Concomitantly, the stereochemistry-converted material gains new stereochemistry-selective activity to undergo photocyclization reactions. The mechanophore thus uses a mechanical approach to converting the axial chirality of a sterically congested diarylethene molecule, modifying its molecular symmetry and its physical and chemical properties in response to an mechanical stimulus.
Artificial lipoproteins bearing non-canonical post-translational modifications that are synthesized by leveraging substrate promiscuity of an acyltransferase. The non-canonical functionality of these lipoprotein results in a distinctive hysteretic assembly that is absent from the canonical lipoproteins and is used to prepare hybrid multiblock materials with precise and programmable patterns of amphiphilicity due to the unique assembly and function of the non-canonical post-translational modifications.
C12P 7/64 - GraissesHuilesCires de type esterAcides gras supérieurs, c.-à-d. ayant une chaîne continue d'au moins sept atomes de carbone liée à un groupe carboxyleHuiles ou graisses oxydées
9.
SURFACE TOPOGRAPHY WITH FERROMAGNETIC POLYMER PILLARS CAPABLE OF MOVEMENT IN RESPONSE TO MAGNETIC FIELDS
An anti-fouling surface having micron scale pillars embedded with Fe3O4 nanoparticles is designed. The pillars may be repeatedly induced to move according to a predetermined frequency, such as one that mimic that of the beating movement of natural cilia, through the application of a magnetic field. When square-shaped pillars with a height of 10 μm, width of 2 μm, and inter-pattern distance of 5 μm actuated for three minutes, more than 99.9 percent of biofilm cells were detached and via gentle rinsing from the surface having the pillars. The anti-fouling surface enables effective prevention of biofilm formation and removal of established biofilms, and can be applied to a broad spectrum of polymers.
An apparatus and method for shaping double-network hydrogels into customized 3D structures. A one-pot prepolymer formulation containing photo-cross-linkable acrylamide and thermoreversible sol-gel κ-carrageenan with a suitable crosslinker, and photo-initiator/absorbers was used. The formulation was polymerized using a TOPS system with heating stage to photo-polymerize the primary acrylamide network into a 3D structure above the sol-gel transition of κ-carrageenan (80° C.). Cooling down then generates the secondary physical κ-carrageenan network to realize tough double-network hydrogel structures. Printed 3D structures had superior lateral (37 μm) and vertical (180 μm) resolutions and 3D design freedoms (internal voids) that exhibit ultimate stress and strain of 200 kPa and 2400% respectively under tension, and simultaneously exhibit high compression stress of 15 MPa with a strain of 95%, both with high recovery rates. The apparatus and method can be employed with other double-network hydrogels to make multifunctional soft devices for a range of applications.
C08L 33/26 - Homopolymères ou copolymères de l'acrylamide ou de la méthacrylamide
B29C 35/08 - Chauffage ou durcissement, p. ex. réticulation ou vulcanisation utilisant l'énergie ondulatoire ou un rayonnement corpusculaire
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
A speech analysis system that can accurately determine whether a predetermined sound in a spoken work has been correctly pronounced. The speech analysis system includes a machine learning algorithm that has been trained to consider temporal and spectral information about the frame-by-frame components of a target sound. The speech analysis system is personalized based on previous therapy recordings for a speaker's specific error and correct/mispronounced exemplars from speakers with matched vocal tracts. The speech analysis system may be integrated into an adaptive therapy program, such as Speech Motor Chaining, to provide an assessment of proper speech and personalized biofeedback in the place of a live clinician.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G10L 15/16 - Classement ou recherche de la parole utilisant des réseaux neuronaux artificiels
G10L 15/22 - Procédures utilisées pendant le processus de reconnaissance de la parole, p. ex. dialogue homme-machine
G10L 25/15 - Techniques d'analyse de la parole ou de la voix qui ne se limitent pas à un seul des groupes caractérisées par le type de paramètres extraits les paramètres extraits étant des informations sur les formants
G10L 25/18 - Techniques d'analyse de la parole ou de la voix qui ne se limitent pas à un seul des groupes caractérisées par le type de paramètres extraits les paramètres extraits étant l’information spectrale de chaque sous-bande
G10L 25/66 - Techniques d'analyse de la parole ou de la voix qui ne se limitent pas à un seul des groupes spécialement adaptées pour un usage particulier pour comparaison ou différentiation pour extraire des paramètres en rapport avec l’état de santé
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
Thin elastic films that can spontaneously attach to liquid interfaces, thereby offering a platform for tailoring their physical, chemical, and optical properties. Curved shells can be used to manipulate interfaces in qualitatively different ways. For example, an ultrathin shell with vanishing bending rigidity can impose its own rest shape on a liquid surface, in a process where the pressure across the interface inflates the shell into its original shape. The approach is amenable to optical applications as the shell is transparent, free of wrinkles, and may be manufactured over a range of curvatures.
A steerable robotic needle formed from a compliant wire that is surrounded by an inner layer having one or more tunable regions positioned in predetermined locations and an inert region extending over the rest of the wire. The tunable region changes stiffness in response to an external trigger, such as heating via electrical energy, so that the needle can bend more readily in the predetermined location. The inner layer may be encapsulated in an elastomeric tube to prevent heat from reaching the surrounding environment. The resulting change in stiffness allows the needle to perform maneuvers in a body that require a larger curvature.
A61L 31/12 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
14.
ANTI-WETTING, NON-STICK SURFACES FROM A PHOTOPOLYMER-NANOPARTICLE FORMULATION
A polymer film having a non-planar surface defined by a series of surface bumps and a plurality of nanoparticles in the polymer film, wherein the nanoparticles are more concentrated proximately to surface and in the surface bumps to provide anti-wetting and anti-stick properties. The polymer coating is formed by casting a thin layer of a photopolymerizable polymer precursor having a plurality of nanoparticles over a transparent substrate and then irradiating the thin layer from below with a periodic light field so that the photopolymerizable polymer precursor forms a polymer with a non-planar surface and the nanoparticles are concentrated proximately to the non-planar surface as a result of phase separation. The resulting film can be washed with a solvent to remove any uncured polymer and peeled away from the substrate for use as an anti-stick and anti-wetting coating.
A two-stage treatment process for destroying per- and polyfluoroalkyl substances (PFAS) in an aqueous stream. The two-stage treatment process uses a combination of multifunctional crystalline molecular sieves, such as zeolites and zeotypes, to separate PFAS from the aqueous stream, catalytically decompose and defluorinate any PFAS molecules, and generate non-toxic waste products that are safe for disposal. The first stage includes adsorption of the PFAS within one of a pair of vessels containing porous, hydrophobic, hydrothermally stable molecular sieves, dehydration of the captured PFAS on the sieves, and catalytic ozonation of the captured PFAS molecules on the dried sieves. The second stage involves catalytic decomposition and neutralization of the ozonation results with one of a pair of vessels including a zeolite-supported CaO catalyst, catalytic oxidation of any toxic CO generated by the decomposition, and an acid wash for regeneration of the spent catalyst.
A polymer composite for use as a solar cell encapsulant is defined by a thin film having a first side and an opposing second side and at least one optical structure formed in the film. The least one optical structure includes one or more waveguide formed by a core of a high-refractive index polymer, such as an acrylate and a cladding of a low refractive index polymer, such as a silicone. In a preferred embodiment, two intersecting waveguide arrays are defined, each having waveguides disposed at equal and opposite angles in relation to a normal of a surface of the film. The polymer composite further includes at least one light conversion material that is capable of upconverting and/or downconverting UV and/or IR portions of light entering the film into visible light.
G02B 1/02 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de cristaux, p. ex. sel gemme, semi-conducteurs
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
G02B 6/10 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (USA)
SYRACUSE UNIVERSITY (USA)
Inventeur(s)
Kerr, William
Chisholm, John
Abrégé
Provided are compounds and pharmaceutically acceptable salt, solvate and/or derivative thereof. Further, provided are methods of treating a disease, disorder or condition mediated or treatable by activation of SHIP1 comprising administering a SHIP1 activator compound or a pharmaceutically acceptable salt, solvate or derivative thereof. The compound or a pharmaceutically acceptable salt, solvate or derivative thereof may be used in the treatment of SHIP1 mediated disease, disorder or conditions including inflammatory bowel disease (IBD), Crohn' disease, COPD, ulcerative colitis, arthritis, and Alzheimer's Disease.
A61K 31/541 - Thiazines non condensées contenant d'autres hétérocycles
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
19.
COMPOSITIONS AND METHODS FOR CONTROLLING FOOD INTAKE, ENERGY EXPENDITURE, AND BODY WEIGHT FOR THE TREATMENT OF OBESITY AND METABOLIC DISEASES
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
20.
COMPOSITIONS COMPRISING OCTADECANEUROPEPTIDES (ODN) AND SYNTHETIC DERIVATIVES THEREOF AND METHODS OF USE FOR MODULATION OF FOOD INTAKE, OBESITY, BODY WEIGHT, NAUSEA, AND EMESIS
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (USA)
SYRACUSE UNIVERSITY (USA)
Inventeur(s)
Hayes, Matthew, R.
Doyle, Robert, P.
Geisler, Caroline
Chichura, Kylie, S.
Reiner, Benjamin, C.
Crist, Richard, C.
Abrégé
Compositions and methods for the management and treatment of obesity, metabolic disorders, nausea and emesis using a ODN peptides and synthetic derivatives thereof are disclosed.
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
A61P 1/08 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des nausées, du mal des transports ou des vertigesAntiémétiques
A method of forming complex ceramic structures without altering the ceramic microstructure. A tape cast ceramic substrate is masked and then sprayed with a film having a different thermal expansion coefficient than the tape cast ceramic substrate. The mask is removed to leave the desired pattern of film on the tape ceramic substrate. As the substrate and film cools down from the peak sintering temperature, deformation occurs due to the different thermal expansion coefficients. By varying film thickness and deposition pattern, the composite can be designed to deform only in certain areas, allowing for well-controlled folding of the tape cast ceramic composite to provide for folding into complex shapes.
H01M 8/1226 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé caractérisés par la combinaison électrode/électrolyte ou par le matériau de support caractérisés par la couche de support
H01M 8/1253 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé caractérisés par le procédé de fabrication ou par le matériau de l’électrolyte l'électrolyte étant constitué d’oxydes l'électrolyte contenant de l’oxyde de zirconium
22.
GENERALIZABLE NANOPORE SENSOR FOR HIGHLY SPECIFIC PROTEIN DETECTION AT SINGLE-MOLECULE PRECISION
A new class of sensing elements made of a protein pore fused to a programmable antibody-mimetic binder. This modular design expands the utility of nanopore sensors to numerous proteins while preserving their architecture, specificity, and sensitivity. The sensing elements were validated with protein analytes that drastically vary in size, charge, and structural complexity. These analytes produce unique electrical signatures that depend on their identity and quantity and the binder-analyte assembly at the nanopore tip.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
23.
HIGHLY TUNABLE DRY ADHESION OF SOFT HOLLOW PILLARS THROUGH SIDEWALL BUCKLING UNDER LOW PRESSURE
An approach to achieve highly tunable adhesion using low pressure by inducing sidewall buckling in soft hollow pillars (SHPs). Dry adhesion of these SHPs can be changed by two orders of magnitude (up to 145×) using low activating pressure (˜−10 kPa or ˜20 kPa). Negative pressure triggers sidewall buckling while positive pressure induces sidewall bulging, both of which can significantly change stress distribution at the bottom surface to facilitate crack initiation and reduce adhesion therein. A single SHP can be activated by a micropump to manipulate various lightweight objects with different curvature and surface texture. An array of SHPs can realize selective pick-and-place of an array of objects. Minor modifications to the SHPs in terms of geometry and material (with or without cap, circular or noncircular cross section) can further enhance the adhesion tuning performance of these SHPs.
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, UNIVERSITY AT BUFFALO (USA)
Inventeur(s)
Cybulskis, Viktor
Liu, Jingzhi
Kyriakidou, Eleni
Mon, Tala
Abrégé
49090's below 400 °C and remain hydrothermally stable over extended periods of time. The zeolite catalyst may be made by a molar gel composition of the appropriate reagents that is heated in a reaction vessel and then subjected to ion exchange with a source of palladium to achieve less than 2 weight percent loading of palladium in the zeolite.
A complex of magnesium maltol that can deliver magnesium via oral administration at a low cost. The magnesium maltol is formed by dissolving an amount of maltol in water. A solution of citric acid and magnesium oxide is added to the maltol, allowed to react, and then dried to obtain magnesium maltol. The approach may also be used to produce magnesium ethylmaltol. Cellular uptake studies demonstrate that both magnesium maltol and magnesium ethylmaltol provide a substantial uptake of magnesium and thus the complexes offer a route for magnesium supplementation such as that needed by patients with hypomagnesemia.
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
26.
SYSTEM FOR MINIMIZING INDOOR INFECTION RISK AND MAXIMIZING ENERGY SAVINGS
A system and method for minimizing indoor infection risk and improving indoor air quality (IAQ) while maximizing energy savings. The system integrates occupancy detection and forecasting, outdoor weather conditions and forecasting, indoor infection risks and air quality modeling, any tunable air filtration, the clean air delivery rate, and any portable air cleaners. The system outputs the total amount of outdoor air intake, the air temperature of the supply air into the space, the supply air flow rate into the space, the operation mode of tunable air filtration/purification/disinfection, the operation mode of the in-room air cleaner, and space/room temperature set-points, and thus can serve as the central controller for an HVAC system.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
F24F 11/80 - Systèmes de commande caractérisés par leurs grandeurs de sortieDétails de construction de tels systèmes pour la commande de la température de l’air fourni
F24F 11/74 - Systèmes de commande caractérisés par leurs grandeurs de sortieDétails de construction de tels systèmes pour la commande de l’apport en air traité, p. ex. commande de la pression pour la commande du débit d'air ou de la vitesse de l’air
F24F 11/46 - Amélioration de l’efficacité électrique ou économie d’énergie électrique
G05B 19/042 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques
F24F 130/10 - Informations ou prévisions météorologiques
F24F 8/10 - Traitement, p. ex. purification, de l'air fourni aux locaux de résidence ou de travail des êtres humains autrement que par chauffage, refroidissement, humidification ou séchage par séparation, p. ex. par filtrage
F24F 140/40 - Positions des registres, p. ex. ouverts ou fermés
A testing apparatus for evaluating a medical implant for electric potential oscillations that lead to corrosion. The testing apparatus uses a uniaxial load device having a mounting base for accepting a medical implant and orienting the implant along a predetermined axis, a support plate positioned under the uniaxial load device and moveable to apply a force to the implant, a load cell positioned above the mounting plate to measure the force applied to the implant, and a set of differential variable reluctance transducers positioned to measure motion of the implant. A chamber encloses the uniaxial load device so that the implant can be submerged in a fluid replicating human synovial fluid. A faraday cage surrounds the chamber for isolation from environmental electromagnetic radiation. An array of near field antenna are positioned circumferentially around the chamber and driven by a multi-frequency generator.
A process for converting avocado peels into hard carbon-based anodes for sodium ion batteries and a hard carbon material formed according to that process. The avocado peels are simply washed and dried, and then carbonized using a high temperature conversion step. Electrochemical measurements confirmed the applicability of avocado-derived hard carbon as electrode active materials, with high reversible capacities of 320 mAh/g over 50 cycles at 50 mA/g, good rate performance of 86 mAh/g at 3500 mA/g, and Coulombic efficiencies above 99.9% after 500 cycles.
Non-naturally occurring perinatal mesenchymal stem cells differentiated from human induced pluripotent stem cells. The differentiation medium includes an amount of SB431542, an amount of BMP-4, and an amount of PD173074 and is repeated over the course of six days period until perinatal mesenchymal stem-like cells are formed. The resulting non-naturally occurring perinatal mesenchymal stem cells exhibit the relevant characteristics of naturally occurring perinatal mesenchymal stem cells, such as the positive expression of the mesenchymal stem cell markers CD73, CD90, and CD105. The non-naturally occurring perinatal mesenchymal stem cells may be used to produce paracrine factors and similar compounds for therapeutic purposes.
A programmable assembly of proteins into well-defined nanoworms with broadened stability regimes is disclosed. Posttranslational modifications (PTMs) were used to generate lipidated proteins with precise topological and compositional asymmetry. Using an integrated experimental and computational approach, the material properties (thermoresponse and nanoscale assembly) of these hybrid amphiphiles are modulated by their amphiphilic architecture. The judicious choice of amphiphilic architecture can be used to program the assembly of proteins into adaptive nanoworms that undergo a morphological transition (sphere-to-nanoworms) in response to temperature stimuli.
Exemplary methods, systems, apparatus, and computer programs are disclosed for an unmanned aerial system (UAS) inspection system that includes an unmanned aerial system and analysis system for exterior building envelopes and energy performance evaluation and simulation. The UAS can autonomously and systematically collect data for a building's exterior using a payload comprising (i) nondestructive testing (NDT) sensors configured for imaging (visible, infrared, or more) the building and (ii) one or more multi-spectral sensors (LiDAR, ultrasound, radar, or more). The acquired sensor data are provided to an analysis system comprising computer vision (CV) and signal processing modules configured to analyze the acquired data to i) identify building objects (doors, windows, rooftop units, and others) ii) characterize envelope properties (components, heat resistivity, or others) and 3) identify initial thermal anomalies (thermal bridges, physical defects, or infiltration / exfiltration) in a processing pipeline.
Pseudomonas aeruginosa in the presence and absence of different antibiotics. Drug-resistant strains were used as controls. Bacterial growth was detected within 30 mins of culture inoculation, allowing rapid determination of antibiotic susceptibility at the phenotypic level. The pattern shown in the LC sensor AST is consistent with results collected with traditional optical density (OD) 600 nm measurement, additional validation was also performed with lysogeny broth (LB) dosed with fetal bovine serum (FBS). With the compatibility with 96-well plates, this rapid AST may be used for low-cost, point-of-care applications.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
33.
FABRICATION OF NORMAL CONDUCTING OR LOW-GAP ISLANDS FOR DOWNCONVERSION OF PAIR-BREAKING PHONONS IN SUPERCONDUCTING QUANTUM CIRCUITS
Disclosed herein is a quantum processor comprising a substrate, a qubit structure formed on the substrate, an electroplated phonon downconversion material, and furrows through the electroplated phonon downconversion material forming a plurality of electroplated phonon downconversion islands coupled to the substrate configured to channel deposited energy away from the qubit structure. Also disclosed are methods of making and using the same.
G06N 10/70 - Correction, détection ou prévention d’erreur quantique, p. ex. codes de surface ou distillation d’état magique
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
H01L 21/304 - Traitement mécanique, p. ex. meulage, polissage, coupe
34.
TORCHIERE WITH AIR FLOW MECHANISM AND ULTRAVIOLET DISINFECTION
A torchiere style sanitizing device for disinfecting airborne pathogens while providing aesthetic area lighting. A reversible fan exchanges air between the upper room air plume and the lower air plume by passing the air through a center disinfecting section. The disinfection section may include a linear UV-C light, reflective tube, and light trap positioned at one or both ends of the disinfection section to maximize the exposure of the air to the UV-C light and contain the UV-C light within the device. The device includes a conventional illumination source in an upper shade and can selectively provide one of more of room air flow, room air disinfection, and room illumination.
Disclosed herein is a quantum processor comprising a substrate, a qubit structure formed on the substrate, an electroplated phonon downconversion material, and furrows through the electroplated phonon downconversion material forming a plurality of electroplated phonon downconversion islands coupled to the substrate configured to channel deposited energy away from the qubit structure. Also disclosed are methods of making and using the same.
ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS (France)
Inventeur(s)
Paulsen, Joseph, D.
Demery, Vincent
Abrégé
Thin elastic films that can spontaneously attach to liquid interfaces, thereby offering a platform for tailoring their physical, chemical, and optical properties. Curved shells can be used to manipulate interfaces in qualitatively different ways. For example, an ultrathin shell with vanishing bending rigidity can impose its own rest shape on a liquid surface, in a process where the pressure across the interface inflates the shell into its original shape. The approach is amenable to optical applications as the shell is transparent, free of wrinkles, and may be manufactured over a range of curvatures.
A patterned surface structure formed from a ferrofluidic polymer resin having a plurality of magnetic nanoparticles. The polymer resin is patterned with a magnetic field that is applied to the ferrofluidic polymer resin during curing. The ferrofluidic polymer resin may be cast over a non-magnetic planar substrate. A magnetic field is applied to the ferrofluidic polymer resin to induce a pattern in a surface of the ferrofluidic polymer resin. The patterned ferrofluidic polymer resin is then cured to form the permanently patterned surface.
A developmental toxicity screening assay using spatially organized cardiac organoids with contracting cardiomyocytes in the center surrounded by stromal cells distributed along the pattern perimeter engineered from human induced pluripotent stem cells (hiPSCs). Cardiac organoids generated from 600 μm-diameter circles were used as a developmental toxicity screening assay for the quantification of the embryotoxic potential of nine pharmaceutical compounds. The cardiac organoids were demonstrated as having a potential use as an in vitro platform for studying organoid structure-function relationships, developmental processes, and drug-induced cardiac developmental toxicity.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
39.
Control of electrically driven corrosion of medical implants
A dampening device that can be coupled to a medical implant to eliminate harmful electrical oscillations. The device includes circuity that detects harmful electrical oscillations in the implant. The device also includes circuity that generates cancelling electrical signals that counter the detected electrical oscillations. Alternatively, in a medical implant having a taper junction such as a standard hip implant, resistance welding of the taper junction just prior to surgical implanting may be performed after the appropriately dimensioned components are selected to eliminate a metal on metal interface where corrosion is most likely to occur.
A two-stage treatment process for destroying per- and polyfluoroalkyl substances (PFAS) in an aqueous stream. The two-stage treatment process uses a combination of multifunctional crystalline molecular sieves, such as zeolites and zeotypes, to separate PFAS from the aqueous stream, catalytically decompose and defluorinate any PFAS molecules, and generate non-toxic waste products that are safe for disposal. The first stage includes adsorption of the PFAS within one of a pair of vessels containing porous, hydrophobic, hydrothermally stable molecular sieves, dehydration of the captured PFAS on the sieves, and catalytic ozonation of the captured PFAS molecules on the dried sieves. The second stage involves catalytic decomposition and neutralization of the ozonation results with one of a pair of vessels including a zeolite-supported CaO catalyst, catalytic oxidation of any toxic CO generated by the decomposition, and an acid wash for regeneration of the spent catalyst.
A rechargeable calcium battery formed from a calcium metal anode, a cathode formed from a composite carbon/sulfur (C/S), a metal oxide, or a metal sulfide, and a multi-component electrolyte containing a mixture of different salts. The calcium anode is formed as a thin, pure calcium metal foil that is polished and combined with a copper collector for redox activity. The cathode may be formed from a carbon-sulfur (CS) composite or metal oxide/sulfide, such as CaMxOy or CaMxSy, or formed from binary and ternary metals, such as CaM1aM2bOy/Sy and CaM1aM2bM3cOy/Sy. The battery also includes a multi-component electrolyte including calcium salts, such as Ca(TSFI)2, Ca(ClO4)2, Ca(BF4)2, and CaPF6, or the pairing of lithium, sodium and potassium salts with one of the anions, such as Ca(TFSI), NaPF6, and Li(TFSI).
H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
H01M 4/36 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs
H01M 4/525 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer d'oxydes ou d'hydroxydes mixtes contenant du fer, du cobalt ou du nickel pour insérer ou intercaler des métaux légers, p. ex. LiNiO2, LiCoO2 ou LiCoOxFy
H01M 4/505 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de manganèse d'oxydes ou d'hydroxydes mixtes contenant du manganèse pour insérer ou intercaler des métaux légers, p. ex. LiMn2O4 ou LiMn2OxFy
H01M 10/0569 - Matériaux liquides caracterisés par les solvants
H01M 10/0568 - Matériaux liquides caracterisés par les solutés
An HVAC control system having a cloud-based optimization engine in communication with a local building hub that interfaces with the building HVAC system and room units. The cloud-based optimization engine implements an optimal and predictive control strategy to integrate occupancy prediction, weather forecasting, and modeling of indoor infection risk, indoor air quality, and building energy consumptions. The control strategy includes a model-based predictive control and a model-free reinforcement learning approach. The control strategy considers outdoor weather (both thermal and air quality) conditions, indoor occupancy and requirements for IAQ and infectious risk reduction to decide whether outdoor air should be introduced and how much fresh air will be introduced into the space. Communications with the building hub allow the local HVAC unit to be driven according to the optimization plan. Individual room sensing units can provide local sensor data to the cloud-based optimization engine.
F24F 11/65 - Traitement électronique pour la sélection d'un mode de fonctionnement
F24F 11/00 - Aménagements de commande ou de sécurité
F24F 11/46 - Amélioration de l’efficacité électrique ou économie d’énergie électrique
G05B 19/042 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques
Imaging agents that can bind to ghrelin O-acyltransferase (GOAT) without binding to the ghrelin receptor (GHS-R1a). The imaging agents comprise a base structure for selective binding to GOAT that is coupled via an amino acid linker to a chemical group to enable imaging such as a fluorescent label, radioactive tracer, or metal chelator. For example, the imaging agent may comprise a ghrelin substrate mimetic inhibitor incorporating an unmodified 2,3-diaminopropanoic acid (Dap) group at the site analogous to serine 3. These agents enable specific detection and imaging of GOAT versus the GHS-R1a receptor in a variety of biological contexts.
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
G01N 33/573 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour enzymes ou isoenzymes
G01N 33/60 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées faisant intervenir des substances marquées radioactives
44.
PHARMACEUTICAL FORMULATIONS AND METHODS FOR DELIVERING A THERAPEUTIC, DIAGNOSTIC, OR IMAGING AGENT TO CD206
The present disclosure provides pharmaceutical formulations and methods for delivering a therapeutic, diagnostic, or imaging agent to CD206. In an aspect, the present disclosure encompasses a pharmaceutical formulation for administration. The pharmaceutical formulation comprises a recombinantly produced intrinsic factor (IF), wherein the IF has a glycosylation pattern that enables binding to CD206.
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
45.
COMPACT, HIGH-EFFICIENCY AIR HANDLING UNIT FOR RESIDENTIAL HVAC SYSTEMS
An air handler unit for use with residential heating, ventilation, and air conditioning (HVAC) systems. The air handler unit has high resistance mediums (HRMs) coupled closely to a wide-angle vane-diffuser mixed-flow fan system. The HRMs are placed immediately upstream and downstream of the wide-angle vane-diffuser mixed-flow fan to form a closely coupled, compact air handler that provides significant efficiency and noise benefits.
A shape memory polymer hydrogel that is biodegradable, includes antimicrobial agents, and has a tunable drug delivery is used for wound healing internally and externally. The shape memory polymer is synthesized using a combination of hydrophilic precursors that are configured to have two to four functional end groups, with at least one component that has at least three functional groups. The synthesis route provides for a covalently crosslinked thermoset hydrogel. The chemistry can be tuned to provide desired transition temperatures for delivery (e.g. below 37° C.) and desired pore sizes for healing (e.g. 250-500 μm).
A61L 27/48 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges macromoléculaires
A series of chimeric peptides that provide a mechanism for obesity treatment concomitant with T2DM in the form of dual agonism of the anorectic neuropeptide Y-receptor (Y2-R) and the glucoregulatory receptor GLP1-R. Preliminary results show that, dependent on the selected peptide, once-daily administration suppress FI in male and female rats can be reduced to 12-65% compared to baseline conditions before treatment, dependent on dose and age of animals, and glucose tolerance can be improved as well. Peptides also demonstrated Y1-receptor agonism, conferring protection on beta-islet cells against inflammatory damage. The peptides were designed by targeting serial anorectic pathways simultaneously and are promising candidates for modulating FI and glucoregulation in an efficacious and safe way.
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
49.
Superconducting metamaterials for quantum simulations and qubit addressability in quantum processors
Superconducting metamaterials composed of lumped-element inductors and capacitors are used to implement microwave photonics with novel dispersion relations and dense mode spectra that can be coupled to qubits. Metamaterial lattices may have qubits coupled to different unit cells in the metamaterial such that each qubit will couple strongly to modes with an antinode at the qubit location. Through simultaneous driving of combinations of modes, large amplitudes are produced at only one or a few unit cells, resulting in large ac Stark shifts of qubits located there, and providing a frequency-addressable qubit array without requiring flux-tunability and with reduced control wiring.
H01L 39/02 - Dispositifs utilisant la supraconductivité ou l'hyperconductivité; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives - Détails
G06N 10/00 - Informatique quantique, c.-à-d. traitement de l’information fondé sur des phénomènes de mécanique quantique
A system and method for minimizing indoor infection risk and improving indoor air quality (IAQ) while maximizing energy savings. The system integrates occupancy detection and forecasting, outdoor weather conditions and forecasting, indoor infection risks and air quality modeling, any tunable air filtration, the clean air delivery rate, and any portable air cleaners. The system outputs the total amount of outdoor air intake, the air temperature of the supply air into the space, the supply air flow rate into the space, the operation mode of tunable air filtration/purification/disinfection, the operation mode of the in-room air cleaner, and space/room temperature set-points, and thus can serve as the central controller for an HVAC system.
F24F 8/10 - Traitement, p. ex. purification, de l'air fourni aux locaux de résidence ou de travail des êtres humains autrement que par chauffage, refroidissement, humidification ou séchage par séparation, p. ex. par filtrage
F24F 11/65 - Traitement électronique pour la sélection d'un mode de fonctionnement
F24F 11/46 - Amélioration de l’efficacité électrique ou économie d’énergie électrique
F24F 11/74 - Systèmes de commande caractérisés par leurs grandeurs de sortieDétails de construction de tels systèmes pour la commande de l’apport en air traité, p. ex. commande de la pression pour la commande du débit d'air ou de la vitesse de l’air
F24F 11/80 - Systèmes de commande caractérisés par leurs grandeurs de sortieDétails de construction de tels systèmes pour la commande de la température de l’air fourni
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G05B 19/042 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques
F24F 130/10 - Informations ou prévisions météorologiques
F24F 11/00 - Aménagements de commande ou de sécurité
A hybrid laser printing (HLP) technology that utilizes ultrafast laser in sequential additive-subtractive modes to create 3D hydrogel constructs. The approach involves the synergistic use of additive crosslinking and subtractive ablation processes that are conventionally mutually exclusive. HLP can be operated at virtually any penetration depth and allow fabrication of multi-layer hydrogel constructs at micrometer resolution. HLP was used to print ready-to-use functional chips using commonly used hydrogels for potential cellular communication and migration applications. HLP was also found to be compatible with in situ printing of cell-laden hydrogel constructs. HLP makes shaping of soft hydrogels into 3D multiscale functional devices possible.
B29C 64/135 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p. ex. par irradiation globale combinée avec un masque la source d’énergie étant concentrée, p. ex. lasers à balayage ou sources lumineuses focalisées
B29C 64/277 - Agencements pour irradiation utilisant des moyens de rayonnement multiples, p. ex. des micro-miroirs ou des diodes électroluminescentes multiples [LED]
G02F 1/37 - Optique non linéaire pour la génération de l'harmonique deux
Artificial lipoproteins bearing non-canonical post-translational modifications that are synthesized by leveraging substrate promiscuity of an acyltransferase. The non-canonical functionality of these lipoprotein results in a distinctive hysteretic assembly that is absent from the canonical lipoproteins and is used to prepare hybrid multiblock materials with precise and programmable patterns of amphiphilicity due to the unique assembly and function of the non-canonical post-translational modifications.
C12P 7/64 - GraissesHuilesCires de type esterAcides gras supérieurs, c.-à-d. ayant une chaîne continue d'au moins sept atomes de carbone liée à un groupe carboxyleHuiles ou graisses oxydées
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (USA)
SYRACUSE UNIVERSITY (USA)
Inventeur(s)
Hayes, Matthew Robert
De Jonghe, Bart C.
Borner, Tito
Doyle, Robert
Tinsley, Ian
Abrégé
The present invention relates to engineered peptides and to methods of making engineered peptides. The present invention also relates to methods of treatment comprising administration of the engineered peptides to a subject in need thereof.
C07K 14/475 - Facteurs de croissanceRégulateurs de croissance
A61K 47/55 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique l’agent de modification étant aussi un agent pharmacologiquement ou thérapeutiquement actif, c.-à-d. le conjugué entier étant un co-médicament, p. ex. un dimère, un oligomère ou un polymère de composés pharmacologiquement ou thérapeutiquement actifs
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
A61K 47/55 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique l’agent de modification étant aussi un agent pharmacologiquement ou thérapeutiquement actif, c.-à-d. le conjugué entier étant un co-médicament, p. ex. un dimère, un oligomère ou un polymère de composés pharmacologiquement ou thérapeutiquement actifs
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (USA)
SYRACUSE UNIVERSITY (USA)
Inventeur(s)
Kerr, William
Pedicone, Chiara
Chisolm, John D.
Dormann, Shawn
Abrégé
The present disclosure provides methods of using compositions tliat inhibit SH2-containing inositol 5′-pliospliatases (SHIPs) for activating microglial cells, as well as methods for using such compositions for treatment or ameliorating of neurodegenerative disorders in a subject.
A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p. ex. cholane, cholestane, ergostérol, sitostérol
A61K 31/4045 - Indole-alkylaminesLeurs amides, p. ex. sérotonine, mélatonine
A61K 31/5685 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en positions 10 et 13 par une chaîne ayant au moins un atome de carbone, p. ex. androstane, testostérone ayant un groupe oxo en position 17, p. ex. androstérone
A61K 31/568 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en positions 10 et 13 par une chaîne ayant au moins un atome de carbone, p. ex. androstane, testostérone
A61K 31/57 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone
56.
METAL DI-AMINO ACID CHELATES OR METAL TRI-AMINO ACID CHELATES
C07C 229/04 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé
A61K 31/202 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique ayant au moins trois doubles liaisons, p. ex. acide linolénique
C07K 1/107 - Procédés généraux de préparation de peptides par modification chimique de peptides précurseurs
C07C 229/26 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant plus d'un groupe amino lié au squelette carboné, p. ex. lysine
58.
METAL DI-AMINO ACID CHELATES OR METAL TRI-AMINO ACID CHELATES
A system for collecting, growing, and analyzing biological specimens that may present a health threat. The system includes separate modules for specimen collection, sample isolation, and sample analysis that can be interconnected to safety process, culture, and analyze and unknown specimen. A decapitation module allows a user to safely collect a swab tip containing an unknown sample and transport the sample to a culture module where the sample can be washed from the swab tip and isolated in a cuvette for growth and analysis. The culture module may be coupled to a base station that can provide mixing, heating and cooling, as well as optical and spectral analysis.
A hybrid power system for an unmanned aerial system (UAS) having a liquid fuel engine and a solid oxide fuel cell coupled to the exhaust of the engine for generating electricity that is used by the electric motors of the UAS to create lift and control flight. A conventional remote control (r/c) liquid fuel engine may be used generate exhaust gases including hydrogen and carbon monoxide that are used by a SOFC coupled to the exhaust of the r/c engine to generate electricity. The electric motors of the UAS may thus be powered by the electricity generated by the SOFC.
B64D 27/24 - Aéronefs caractérisés par le type ou la position des groupes moteurs utilisant la vapeur ou l'énergie de ressorts
B60L 50/60 - Propulsion électrique par source d'énergie intérieure au véhicule utilisant de la puissance de propulsion fournie par des batteries ou des piles à combustible utilisant de l'énergie fournie par des batteries
B60L 50/70 - Propulsion électrique par source d'énergie intérieure au véhicule utilisant de la puissance de propulsion fournie par des batteries ou des piles à combustible utilisant de l'énergie fournie par des piles à combustible
B64C 39/02 - Aéronefs non prévus ailleurs caractérisés par un emploi spécial
B64D 33/04 - Aménagement sur les aéronefs des éléments ou des auxiliaires des ensembles fonctionnels de propulsion, non prévu ailleurs des sorties d'échappement ou des tuyères
B64D 41/00 - Installations génératrices de puissance pour servitudes auxiliaires
H01M 8/00 - Éléments à combustibleLeur fabrication
H01M 8/0612 - Combinaison d’éléments à combustible avec des moyens de production de réactifs ou pour le traitement de résidus avec des moyens de production des réactifs gazeux à partir de matériaux contenant du carbone
H01M 16/00 - Combinaisons structurelles de différents types de générateurs électrochimiques
H02K 7/18 - Association structurelle de génératrices électriques à des moteurs mécaniques d'entraînement, p. ex. à des turbines
B64D 27/02 - Aéronefs caractérisés par le type ou la position des groupes moteurs
H01M 8/12 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé
B64U 50/19 - Propulsion utilisant des moteurs électriques
62.
SYNTHESIS OF SUPERHYDROPHOBIC MICROPOROUS SURFACES VIA LIGHT-DIRECTED PHTOPOLYMERIZATION AND PHASE SEPARATION
The formation of microporous surfaces through polymer induced phase separation in a photopolymer solvent mixture using photopolymerization via light self-focusing and self-trapping. The self-trapping of light sets fixed regions of brightness and darkness, sustained by the polymerization of light, and then wave guiding within the substrate. Phase separation occurs with the solvent phase separating in the regions of darkness and crosslinking in the regions of brightness. Upon removal of the solvent, precise and uniformly dispersed pores are created in the surface. The pore size and spacing may be tuned by adjusting the weight fraction of the photopolymer solvent mixture as well as through changes in the mask pattern.
G03F 7/16 - Procédés de couchageAppareillages à cet effet
G03F 7/031 - Composés organiques non couverts par le groupe
C08J 9/28 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement par élimination d'une phase liquide d'un objet ou d'une composition macromoléculaire, p. ex. par séchage du coagulum
An assay and kit for detecting N-retinylidene-N-retinylethanolamine (A2E) in a sample that uses a lipid binding protein, such as Saposin B, to capture A2E in the sample and assist in the extraction and measurement of A2E via mass spectroscopy. A2E thus serves as a marker for macular degeneration so that the assay and kit of the invention can be used to detect the presence or severity of macular degeneration.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
G01N 33/92 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des lipides, p. ex. le cholestérol
64.
Hybrid additive-subtractive laser fabrication platform for shaping hydrogels
A hybrid laser printing (HLP) technology that utilizes ultrafast laser in sequential additive-subtractive modes to create 3D hydrogel constructs. The approach involves the synergistic use of additive crosslinking and subtractive ablation processes that are conventionally mutually exclusive. HLP can be operated at virtually any penetration depth and allow fabrication of multi-layer hydrogel constructs at micrometer resolution. HLP was used to print ready-to-use functional chips using commonly used hydrogels for potential cellular communication and migration applications. HLP was also found to be compatible with in situ printing of cell-laden hydrogel constructs. HLP makes shaping of soft hydrogels into 3D multi scale functional devices possible.
B29C 64/277 - Agencements pour irradiation utilisant des moyens de rayonnement multiples, p. ex. des micro-miroirs ou des diodes électroluminescentes multiples [LED]
B29C 64/135 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p. ex. par irradiation globale combinée avec un masque la source d’énergie étant concentrée, p. ex. lasers à balayage ou sources lumineuses focalisées
G02F 1/37 - Optique non linéaire pour la génération de l'harmonique deux
An approach for differentially isolating eukaryotic (plant and animal) DNA from bacterial DNA prior to sequencing using a combination of size exclusion-based separation and differential cell lysis. The method of the present invention exploits the differences of the cellular size and components of each type of organism to be separated. The composition and nature of the cell wall of plant cells, enzymatic sensitivity of bacterial and animal cells and overall size difference of bacterial and plant/animal cells allows one portion of a mixed sample to be lysed while retaining the integrity of the remaining organisms. Separation of one phylogenetic component then permits the remaining components to be extracted with minimal contribution from the preceding component. The separation of DNAs from differing contributing kingdoms in an unknown sample increases interpretability through decreasing complexity in subsequent sequencing applications.
A method of detecting and quantifying human objects in a given environment by passively observing wireless signals in an interesting environment. Information pertaining to observed wireless signals, such as wireless physical layer data and metadata, encrypted or unencrypted data and metadata in the wireless media-access control layer, and channel state information are extracted from the observed wireless signals and used to detect and quantify human objects in a location. The signals that are observed can originate from a wireless object used by a target of interest, such as cellular phone or workstations, or from infrastructure devices, such as wireless access points, IoT devices, or other transceivers. The signals can also originate from other recognizable signal sources, such as electromagnetic interference introduced by equipment such as elevator motors or microwave ovens.
H04L 9/06 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité l'appareil de chiffrement utilisant des registres à décalage ou des mémoires pour le codage par blocs, p. ex. système DES
67.
METHODS AND SYSTEMS FOR PREDICTION OF A DNA PROFILE MIXTURE RATIO
A system configured to characterize a ratio of contributors to a DNA mixture within a sample, the system including: a sample preparation module configured to generate initial data about the DNA mixture within the sample; a processor comprising a ratio of contributors determination module configured to: (i) receive the generated initial data; (ii) analyze the generated initial data to determine the ratio of contributors to the DNA mixture within the sample; and an output device configured to receive the determined ratio of contributors from the processor, and further configured to output information about the received determined ratio of contributors.
G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
68.
Motion detection and classification using ambient wireless signals
A system for using radio frequency (RF) communication signals to extract situational awareness information thorough deep learning. Pre-processing is performed to maximally preserve discriminating features in spatial, temporal and frequency domains. A specially designed neural network architecture is used for handling complex RF signals and extracting spatial, temporal and frequency domain information. Data collection and training is used so that the learning system desensitizes from features orthogonal to the underlying classification problem.
G01S 13/00 - Systèmes utilisant la réflexion ou la reradiation d'ondes radio, p. ex. systèmes radarSystèmes analogues utilisant la réflexion ou la reradiation d'ondes dont la nature ou la longueur d'onde sont sans importance ou non spécifiées
G01S 7/41 - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe utilisant l'analyse du signal d'écho pour la caractérisation de la cibleSignature de cibleSurface équivalente de cible
G01S 13/56 - Discrimination entre objets fixes et mobiles ou entre objets se déplaçant à différentes vitesses pour la détection de présence
69.
Synthetic disugar hydrocarbons as natural analogs to control microbial behaviors
The Research Foundation for the State University of New York (USA)
Inventeur(s)
Luk, Yan-Yeung
Wang, Guirong
Abrégé
Pseudomonas aeruginosa populations and compared against existing compounds to determine efficacy and utility. Certain DSHs were also to determine the ability to clear bacteria in a mouse pneumonia model.
An air handler unit for use with residential heating, ventilation, and air conditioning (HVAC) systems. The air handler unit has high resistance mediums (HRMs) coupled closely to a wide-angle vane-diffuser mixed-flow fan system. The HRMs are placed immediately upstream and downstream of the wide-angle vane-diffuser mixed-flow fan to form a closely coupled, compact air handler that provides significant efficiency and noise benefits.
A quantum computing transducer having a dense, tunable superconducting metamaterial transmission line (SMTL) spectrum that can resonantly enhance sideband scattering. The resonant enhancement of scattering boosts the scattering rate, and hence also the microwave-to-optical-interface (MOQI) transduction efficiency. Moreover, the integration of mechanical elements with the SMTL to realize the MOQI yields a platform that can be readily interfaced on chip, such as in an integrated circuit, with superconducting-qubit architectures to facilitate the local implementation of two of the essential functionalities required for a quantum repeater, i.e., data egress/ingress and a quantum processing module.
The present disclosure provides pharmaceutical formulations and methods for delivering a therapeutic, diagnostic, or imaging agent to CD206. In an aspect, the present disclosure encompasses a pharmaceutical formulation for administration. The pharmaceutical formulation comprises a recombinantly produced intrinsic factor (IF), wherein the IF has a glycosylation pattern that enables binding to CD206.
A metallo-dielectric waveguide array used as an encapsulation material for silicon solar cells. The array is produced through light-induced self-writing combined with in situ photochemical synthesis of silver nanoparticles. Each waveguide comprises a cylindrical core consisting of a high refractive index polymer and silver nanoparticles homogeneously dispersed in its medium, all of which are surrounded by a low refractive index common cladding. These waveguide array films are processed directly over a silicon solar cell.
H01L 31/042 - Modules PV ou matrices de cellules PV individuelles
H01L 31/054 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails adaptés comme dispositifs de conversion photovoltaïque [PV] Éléments optiques directement associés ou intégrés à la cellule PV, p.ex. moyens réflecteurs ou concentrateurs de lumière
H01L 31/18 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives
An integrated guidance and feedback control scheme for steering an underactuated vehicle through desired waypoints in three-dimensional space. The guidance and control algorithm takes as an input the desired trajectory for the translational motion that passes through the given waypoints, and autonomously generates the desired trajectory for the attitude based on the desired thrust direction to achieve the translational motion trajectory. A feedback control law is obtained to steer the underactuated vehicle towards the desired trajectories in translation and rotation.
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (USA)
SYRACUSE UNIVERSITY (USA)
Inventeur(s)
Hayes, Matthew Robert
De Jonghe, Bart C.
Borner, Tito
Doyle, Robert
Tinsley, Ian
Abrégé
The present invention relates to engineered peptides and to methods of making engineered peptides. The present invention also relates to methods of treatment comprising administration of the engineered peptides to a subject in need thereof.
C07K 14/475 - Facteurs de croissanceRégulateurs de croissance
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C12N 15/12 - Gènes codant pour des protéines animales
76.
PEPTIDE LIGANDS OF THE GDNF FAMILY RECEPTOR A-LIKE (GFRAL) RECEPTOR
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (USA)
SYRACUSE UNIVERSITY (USA)
Inventeur(s)
Hayes, Matthew Robert
De Jonghe, Bart C.
Borner, Tito
Doyle, Robert
Tinsley, Ian
Abrégé
The present invention relates to engineered peptides and to methods of making engineered peptides. The present invention also relates to methods of treatment comprising administration of the engineered peptides to a subject in need thereof.
−1 for the purposes of calculating the pH. The approach was validate in vitro using PBS solutions of known pH. The approach was confirmed in vivo using rat and swine models by probing the immediate vicinity of a contusive spinal cord injury (SCI) in the first minutes and hours after injury. Using a dynamic analysis and the Henderson-Hasselbalch equation, the average of (N=12) noninvasive Raman-based pH measurements of CSF was 7.073±0.156 and at >95% confidence there is no statistically significant difference between the Raman-based and the physically sampled results.
A system and method for automated detection of figure element reuse. The system can receive articles or other publications from a user input or an automated input. The system then extracts images from the articles and compares them to reference images from a historical database. The comparison and detection of matches occurs via a copy-move detection algorithm implemented by a processor of the system. The processor first locates and extracts keypoints from a submission image and finds matches between those keypoints and the keypoints from a reference image using a near neighbor algorithm. The matches are clustered and the clusters are compared for keypoint matching. Matched clusters are further compared for detectable transformations. The processor may additionally implement natural language processing to filter matches based on the context of the use of the submission image in the submission and a patch detector for removing false positive features.
G06F 16/58 - Recherche caractérisée par l’utilisation de métadonnées, p. ex. de métadonnées ne provenant pas du contenu ou de métadonnées générées manuellement
79.
Microcombustion micro-tubular flame-assisted fuel cell for power and heat cogeneration without soot formation
2 and CO concentrations in the exhaust were found to have a strong temperature dependence that varies with the maximum wall temperature and the local flame temperature.
H01M 8/1253 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé caractérisés par le procédé de fabrication ou par le matériau de l’électrolyte l'électrolyte étant constitué d’oxydes l'électrolyte contenant de l’oxyde de zirconium
H01M 8/1213 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé caractérisés par la combinaison électrode/électrolyte ou par le matériau de support
H01M 8/04007 - Dispositions auxiliaires, p. ex. pour la commande de la pression ou pour la circulation des fluides relatives à l’échange de chaleur
H01M 8/04014 - Échange de chaleur par des fluides gazeuxÉchange de chaleur par combustion des réactifs
H01M 8/12 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé
A variety of polymeric composites with tunable mechanical stiffness and electrical conductivity are claimed herein. For example, the composite may have an elastomeric matrix, a plurality of tunable particles, and a plurality of conductive fibers embedded in the matrix. The composites may also be a tunable foam matrix and an elastomeric matrix. In some embodiments, the composites are a low melting point alloy (LMPA) foam infiltrated by an elastomer, whose stiffness can be tuned by more than two orders of magnitude through external heating. In other embodiments, the composite may be a conductive particle-fiber-matrix three-component composite capable of changing its elastic rigidity rapidly and reversibly when powered with electrical current.
C08J 9/00 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement
B29C 70/68 - Façonnage de matières composites, c.-à-d. de matières plastiques comprenant des renforcements, des matières de remplissage ou des parties préformées, p. ex. des inserts en incorporant ou en surmoulant des parties préformées, p. ex. des inserts ou des couches
B29K 83/00 - Utilisation de polymères contenant dans la chaîne principale uniquement du silicium avec ou sans soufre, azote, oxygène ou carbone comme matière de moulage
COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Syracuse University (USA)
The Arizona Board of Regent on Behalf of the University of Arizona (USA)
Inventeur(s)
Stromer-Galley, Jennifer
Mckernan, Brian
Rossini, Patricia
Oesterlund, Carsten
Schooler, Lael Jeremy
Folkestad, James Eric
Clegg, Benjamin
Martey, Rosa Mikeal
Kenski, Kate Marian
Myers, Roc Aron
Taylor, Sarah M.
Abrégé
In an example, a computer-implemented method to structure an analytical workflow that improves reasoning based on a problem context and demonstrated abilities of each individual user may include displaying a reasoning problem to an analyst. The method may include receiving input from the analyst to identify a reasoning problem type of the reasoning problem. providing a recommended analytic approach for the reasoning problem type to the analyst. The method may include assisting the analyst in analyzing and evaluating one or more information sources relevant to the reasoning problem. The method may include guiding the analyst through a structured technique (ST) to support reasoning of the analyst in formulation of a solution to the reasoning problem. The method may include generating a report that includes the analyst's solution to the reasoning problem based on input from the analyst.
41 - Éducation, divertissements, activités sportives et culturelles
43 - Services de restauration (alimentation); hébergement temporaire
Produits et services
providing collegiate athletic and sporting events arena services, namely, providing general purpose facilities for sports, concerts and exhibitions; restaurant services
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Clothing, namely, shirts, sweatshirts, jerseys, headwear, footwear, pants, dresses, jackets, vests and socks Charitable services, namely, organizing and conducting volunteer programs and community service projects Arranging and conducting special events for social entertainment purposes; Education services in the nature of courses at the university level; Providing collegiate athletic and sporting events
84.
METHODS AND SYSTEMS FOR ASSESSING THE PRESENCE OF ALLELIC DROPOUT USING MACHINE LEARNING ALGORITHMS
A system configured to characterize the probability of any allele dropout in the sequence of DNA extracted from a sample. The system includes a sample preparation module that can generate sequence data about any DNA within the sample, a processor that is programmed to receive the sequence data and determine the probability of allelic dropout in the sequence data, and an output device that provides the determination of allele dropout to a user of the system.
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
G16B 50/30 - Entreposage de donnéesArchitectures informatiques
G06N 20/10 - Apprentissage automatique utilisant des méthodes à noyaux, p. ex. séparateurs à vaste marge [SVM]
G06F 17/18 - Opérations mathématiques complexes pour l'évaluation de données statistiques
A system that provides intent-oriented browsing powered by machine learning and crowdsourcing. The system allows users to enter their intents, which are then assigned to target pages via supervised learning models based on hyperlinks and contributions made by other users. The system has a prediction server that is programmed to receive hyperlinks from a website and return target hyperlinks based on known intent, a user interface for inputting user intent, and a browser programmed to connect to the intent repository and to the prediction server via a user script. The list of supported intents can grow over time based on correct page marks for intent-page mappings as well as via continuous training of machine learning models.
G06F 16/957 - Optimisation de la navigation, p. ex. mise en cache ou distillation de contenus
G06N 5/04 - Modèles d’inférence ou de raisonnement
G06N 20/10 - Apprentissage automatique utilisant des méthodes à noyaux, p. ex. séparateurs à vaste marge [SVM]
G06F 16/955 - Recherche dans le Web utilisant des identifiants d’information, p. ex. des localisateurs uniformisés de ressources [uniform resource locators - URL]
G06F 16/953 - Requêtes, p. ex. en utilisant des moteurs de recherche du Web
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (USA)
SYRACUSE UNIVERSITY (USA)
Inventeur(s)
Kerr, William
Chisolm, John D.
Abrégé
The present disclosure provides compositions that inhibit the SH2-containing inositol 5'-phosphatase (SHIP), as well as methods using such compositions for use in treating or ameliorating the effects of a medical condition in a subject.
A61K 31/135 - Amines, p. ex. amantadine ayant des cycles aromatiques, p. ex. méthadone
C07C 229/46 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino ou carboxyle liés à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons du même squelette carboné
87.
Cooling charge determination for a local thermal management system
A system and method for estimating the state of charge, i.e., the amount of cooling remaining, in a latent heat thermal storage module of a local environmental control system. The local environmental control system stores cooling energy at night by freezing a latent heat phase change material (PCM), and then releasing the stored cooling energy by removing heat from room air flowing through the PCM during the day. Differential temperature sensors are used measure the air temperature drop across the latent thermals storage unit and the fan voltage, which is directly related to fan air flow rate, is sampled. A controller is programmed to determine the charging state from these measurements.
F28F 27/00 - Commandes ou dispositifs de sécurité spécialement adaptés pour les appareils d'échange ou de transfert de chaleur
F24F 5/00 - Systèmes ou appareils de conditionnement d'air non couverts par ou
F24F 1/029 - Climatiseurs individuels monoblocs pour le conditionnement de l'air, c.-à-d. avec tout l'appareillage nécessaire au traitement placé dans une enveloppe caractérisé par l'agencement ou l’aménagement relatif des composants, p. ex. des compresseurs ou des ventilateurs
88.
Low power and privacy preserving sensor platform for occupancy detection
A low-cost, low-power, stand-alone sensor platform having a visible-range camera sensor, a thermopile array, a microphone, a motion sensor, and a microprocessor that is configured to perform occupancy detection and counting while preserving the privacy of occupants. The platform is programmed to extract shape/texture from images in spatial domain; motion from video in time domain; and audio features in frequency domain. Embedded binarized neural networks are used for efficient object of interest detection. The platform is also programmed with advanced fusion algorithms for multiple sensor modalities addressing dependent sensor observations. The platform may be deployed for (i) residential use in detecting occupants for autonomously controlling building systems, such as HVAC and lighting systems, to provide energy savings, (ii) security and surveillance, such as to detect loitering and surveil places of interest, (iii) analyzing customer behavior and flows, (iv) identifying high performing stores by retailers.
G06V 20/52 - Activités de surveillance ou de suivi, p. ex. pour la reconnaissance d’objets suspects
G08B 13/193 - Déclenchement influencé par la chaleur, la lumière, ou les radiations de longueur d'onde plus courteDéclenchement par introduction de sources de chaleur, de lumière, ou de radiations de longueur d'onde plus courte utilisant des systèmes détecteurs de radiations passifs utilisant des systèmes détecteurs de radiations infrarouges utilisant des moyens de focalisation
A system of topographic patterns for the prevention of bacterial adhesion and biofilm formation. The patterns may be provided on the surfaces of certain devices that are prone to bacterial adhesion and biofilm formation, such as urinary catheters. To reduce bacterial adhesion and biofilm formation, and to remove existing biofilms, the patterns are induced to transform from a first topography to a second topography. For example, the surface patterns may be formed from a shape memory polymer and then heated to transform the patterns from the first topography to the second topography to dislodge bacteria and prevent fouling.
Two peptides that can selectively bind to SEVI and block the enhanced infectivity that results from the interaction of SEVI with HIV. The two peptides comprise the amino acid sequences FEEIVQEIEDFLENLV (SEQ. ID NO: 1) and GIGAVLEVLTTGLPALISWIEEEEQQ (SEQ. ID. NO: 2). The peptides may be administered topically, either alone or in combination with other prophylactics, agents, etc.
A dual chamber solid oxide fuel cell integrated into the exhaust stream of an internal combustion engine, in which engine exhaust gases are routed to the anode of a tubular solid oxide fuel cell (SOFC) and heated secondary air is supplied to the cathode of the SOFC. The secondary air supply is heated using the existing engine temperature and exhaust gas temperature through a heat exchanger formed by a modified cylinder head and exhaust manifold. The dual chamber solid oxide fuel provides the necessary hydrocarbon and carbon monoxide scrubbing to achieve mandatory catalytic conversion for vehicle operation. In addition, the dual chamber solid oxide fuel cell is capable of generating sufficient electrical power for the vehicle. Omission of conventional catalytic convertors and alternators allows for improved efficiency and fuel economy of the internal combustion engine.
H01M 8/06 - Combinaison d’éléments à combustible avec des moyens de production de réactifs ou pour le traitement de résidus
H01M 8/1233 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé avec un des réactifs liquide, solide ou chargé en liquide
H01M 8/1231 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé avec les deux réactifs gazeux ou vaporisés
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (USA)
SYRACUSE UNIVERSITY (USA)
Inventeur(s)
Kerr, William
Pedicone, Chiara
Chisolm, John D.
Dormann, Shawn
Abrégé
The present disclosure provides methods of using compositions that inhibit SH2-containing inositol 5'-phosphatases (SHIPs) for activating microglial cells, as well as methods for using such compositions for treatment or ameliorating of neurodegenerative disorders in a subject.
A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
A61K 31/565 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol
A61K 31/568 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en positions 10 et 13 par une chaîne ayant au moins un atome de carbone, p. ex. androstane, testostérone
93.
ENHANCED TRAINED IMMUNITY IN MYELOID CELLS BY SHIP-1 INHIBITION
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.) (Espagne)
SYRACUSE UNIVERISTY (USA)
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (USA)
Inventeur(s)
Sancho Madrid, David
Saz Leal, Paula
Del Fresno Sánchez, Carlos
Chisholm, John
Kerr, William
Abrégé
The present invention refers to the medical field. Particularly, it refers to SHIP-1 inhibitors for use in enhancing the non-specific response of trained innate immune cells (i.e. enhancing the training of the innate immune cells) in a subject, wherein the SHIP-1 inhibitor is administered before, after or simultaneously to a treatment with a stimulus responsible for training the innate immune cells.
A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p. ex. cholane, cholestane, ergostérol, sitostérol
A communication system that minimizes the transmission of pilot symbols while ensuring real-time channel tracking and symbol detection. The system employs a multiple-input multiple-output (MIMO) transmitter-receiver pair where there are many more receive antennas than transmit antennas. Communication occurs over a wide band RF channel via orthogonal frequency division multiplexing (OFDM) that employs a large number of sub-carriers.
Ae. aegypti and other mosquitoes to bait station and encourages them to land on the coated portion. Once a mosquito has landed, it detects the sugar in the dried mixture of sugar and poison and ingests some of it. Once ingested, the dried mixture of poison and sugar will eventually kill the mosquito.
An enzyme responsive shape memory polymer formed from a glassy, cross-linked shape memory polymer that incorporates ester bonds that are responsive to the present of an enzyme. PCL-based polyurethanes (featuring simple alternation of PCL diol and lysine-based diisocyanate) are degradable by Amano lipase PS. A non-degradable thermoplastic elastomer may be dual electrospun with a polycaprolactone based TPU with the fixing phase compressed so that the composite is ready for enzymatically triggered contraction. Alternatively, the elastomer may be a PCL copolymer-based polyurethane amorphous elastomer that is both degradable and elastomeric and put into compression so that upon enzymatic degradation of the elastomeric phase the scaffold expands.
D04H 1/728 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes caractérisés par la méthode de formation des voiles ou couches, p. ex. par la réorientation des fibres les fibres étant disposées au hasard par électrofilage
D04H 1/4382 - Fibres obtenues par étirage de film réticuléFibres compositesFibres mixtesFibres ultrafinesFibres pour cuir artificiel
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
97.
Website authentication using an internet-connected device
The invention is an authentication framework that enables a user to log in to a website using an Internet-connected device, such as smartphone, smart watch, smart glasses, or tablet, while browsing on a computer. The framework makes it easier for people with certain disabilities to log in to a website, such as by removing the mandatory step of entering usernames and passwords while giving users multiple options through which they are establish their identity using Internet-connected devices. For example, gyroscope, camera, microphone, or the accelerometer can be used to provide credentials. This approach of the framework greatly reduces the number of barriers that a user with disability encounters when trying to use password-based authentication on the Internet.
H04L 29/06 - Commande de la communication; Traitement de la communication caractérisés par un protocole
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
12-Ex4) also improves glucose tolerance without producing anorexia and malaise. A GLP-1R agonist that is resistant to DPP-IV degradation and does not penetrate readily into the CNS, but retains the enhanced pharmacokinetic and pharmacodynamic profile on pancreatic β-cells provide a pharmacological tool for glycemic control in type 2 diabetes mellitus (T2DM) patients without eliciting unwanted hypophagia and nausea.
A61K 47/55 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique l’agent de modification étant aussi un agent pharmacologiquement ou thérapeutiquement actif, c.-à-d. le conjugué entier étant un co-médicament, p. ex. un dimère, un oligomère ou un polymère de composés pharmacologiquement ou thérapeutiquement actifs
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 31/714 - Cobalamines, p. ex. cyanocobalamine, vitamine B12
4 nanoparticles is designed. The pillars may be repeatedly induced to move according to a predetermined frequency, such as one that mimic that of the beating movement of natural cilia, through the application of a magnetic field. When square-shaped pillars with a height of 10 μm, width of 2 μm, and inter-pattern distance of 5 μm actuated for three minutes, more than 99.9 percent of biofilm cells were detached and via gentle rinsing from the surface having the pillars. The anti-fouling surface enables effective prevention of biofilm formation and removal of established biofilms, and can be applied to a broad spectrum of polymers.
B08B 17/06 - Procédés pour empêcher la salissure pour empêcher le dépôt de crasses ou de poussières en donnant aux objets susceptibles de s'encrasser une conformation ou un agencement particulier
B29C 33/00 - Moules ou noyauxLeurs détails ou accessoires
B29C 35/02 - Chauffage ou durcissement, p. ex. réticulation ou vulcanisation
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
Surface modifications and improvements to piezoelectric-based sensors, such as QCMs and other piezoelectric devices, that significantly increase the sensitivity and the specificity (selectivity). These modifications can comprise mechanical and chemical changes to the surfaces of the sensors, either individually or together. For example, nanosize structures may be provided on the surface to improve sensitivity. Additionally, chemical coatings may be tethered to the surfaces, walls, or crystal to provide targeted sensitivity. Additionally, porous, layered and multiple sensor arrays may be formed to enhance sensitivity and selectivity.
