Abrégé

The present disclosure provides a process for the preparation of 3,5-Dihydroxy-4-isopropyl-trans-stilbene [Tapinarof] and related compounds. Aryl hydrocarbon receptor (AHR) agonists are a novel class of drugs for topical treatment of plaque psoriasis in adults. AHR agonists are believed to inhibiting the release of proinflammatory proteins (cytokines) and downregulating inflammation. 3,5-Dihydroxy-4-isopropyl-trans-stilbene, also known as (E)-2-isopropyl-5-styrylbenzene-1,3-diol or Tapinarof, is a naturally occurring compound found in bacterial symbionts of nematodes.

Classes IPC  ?

• C07C 39/21 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques ne contenant que des cycles aromatiques à six chaînons dans la partie cyclique, avec une insaturation autre que celle des cycles au moins un groupe hydroxyle étant lié à un cycle non condensé
• C07C 37/055 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone d'un cycle aromatique à six chaînons par remplacement des groupes fonctionnels liés à un cycle aromatique à six chaînons par des groupes hydroxyle, p. ex. par hydrolyse par substitution d'un groupe lié au cycle par un oxygène, p. ex. d'un groupe éther
• A61P 17/06 - Antipsoriasiques

Produits et services

skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations. acne treatment preparations.

Produits et services

Pharmaceutical preparations and substances for the treatment of coughs, colds and influenza; Pharmaceutical preparations for the treatment and prevention of gastrointestinal diseases and disorders; anti-pyretic preparations; Emergency contraceptive tablets; emergency contraceptive kit composed of oral contraceptives, pregnancy test kits for home use and instructions sold in connection therewith; pharmaceutical preparations for reducing fever; acetaminophen suppositories; menstrual pain relief medications; allergy relief medication; analgesics and pain relievers; allergy and sinus medication; anti-fungal preparations; cough suppressants; decongestants; pharmaceutical antitussive-cold preparations; Pharmaceutical preparations for treatment of alopecia; expectorants; nasal decongestants; Acetaminophen; preparations for the treatment of respiratory and pulmonary conditions; antihistamines

Produits et services

Medicated dermatological preparations and substances; Pharmaceutical preparations for the treatment of autoimmune, cardiovascular, central nervous system, circulatory, dermatological, endocrine, gastrointestinal, genetic, infectious, inflammatory, kidney, liver, metabolic, musculoskeletal, neurodegenerative, neurological, neuromuscular, ophthalmic, psychiatric and viral diseases and disorders; Pharmaceutical preparations for the treatment of alopecia, blood disorders, bone growth disorders, skin disorders, sleep disorders, arthritis, cancer, hypertension, pain, stroke, obesity and diabetes; Pharmaceuticals, namely, anti-infectives

Produits et services

Pharmaceutical preparations and substances for the treatment of coughs, colds and influenza; pharmaceutical preparations for reducing fever; decongestants; cough suppressants; pharmaceutical antitussive-cold preparations; Pharmaceutical preparations for the treatment and prevention of gastrointestinal diseases and disorders; Pharmaceutical preparations for treatment of alopecia; preparations for the treatment of respiratory and pulmonary conditions; expectorants; anti-pyretic preparations; allergy relief medication; allergy and sinus medication; antihistamines; nasal decongestants; analgesics and pain relievers; menstrual pain relief medications; Emergency contraceptive tablets; emergency contraceptive kit composed of oral contraceptives, pregnancy test kits for home use and instructions sold in connection therewith; anti-fungal preparations; Acetaminophen; acetaminophen suppositories

Abrégé

The present disclosure provides a process for the preparation of Trifarotene. The disclosure also provides for intermediates in the process described herein. Also provided are methods of making polymorph Form E of Trifarotene.

Classes IPC  ?

• C07D 207/06 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec uniquement des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux contenant uniquement des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle

Produits et services

skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations acne treatment preparations

Produits et services

skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations acne treatment preparations

Produits et services

skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations acne treatment preparations

Produits et services

skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations acne treatment preparations

Abrégé

The present disclosure provides an oral care device including a hollow shaft (120, 920, 1320), a sleeve (110, 910, 1310), and a cleaning portion (115). The hollow shaft can include a first end having a first suction aperture (140, 940, 1340), and a second end having a second suction aperture (125, 925). The hollow shaft can be configured for insertion into a hand grip. The sleeve can surround the hollow shaft of the oral care device, and can be configured to slide along a longitudinal axis and conceal at least a portion of the first suction aperture or the second suction aperture. The sleeve can conceal the first suction aperture or the second suction aperture to easily adjust an amount of suction provided to an oral cavity of a patient. The cleaning portion can be coupled to a portion of the sleeve at the first end of the hollow shaft.

Classes IPC  ?

• A61C 17/02 - Dispositifs de rinçage ou insufflateurs d'air, p. ex. utilisant des jets de fluide
• A46B 11/06 - Brosses à réservoir ou autre système permettant l'application de produits, p. ex. peintures, pâtes, eau reliées à un tuyau d'alimentation
• A61C 17/12 - Dispositifs de commande, p. ex. pour l'aspiration

Produits et services

(1) Analgesics; antacids; anti-cancer preparations; antibiotics; anticoagulants; anticonvulsants; antidepressants; antidiabetic preparations; antifungal preparations; antihypertensives; antiseptic preparations; antivirals; calcium channel blockers; corticosteroids; laxatives; nausea treatment preparations; pharmaceutical preparations for controlling cholesterol; pharmaceutical preparations for maintaining normal blood pressure and heart function; pharmaceutical preparations for reducing cholesterol; pharmaceutical preparations for the prevention and treatment of cancer; pharmaceutical preparations for the prevention and treatment of iron deficiency and anemia in humans; pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; pharmaceutical preparations for the treatment and prevention of migraines, headaches and pain; pharmaceutical preparations for the treatment of blood disorders; pharmaceutical preparations for the treatment of dermatological conditions being acne, rosacea, ichthyosis, vitiligo, urticaria and alopecia areata; pharmaceutical preparations for the treatment of dermatological diseases and disorders namely dermatitis, skin and bacterial skin infections and fungal skin infections.; pharmaceutical preparations for the treatment of digestive diseases and disorders, namely, ulcerative colitis; pharmaceutical preparations for the treatment of erectile dysfunction; pharmaceutical preparations for the treatment of gastro-intestinal diseases; pharmaceutical preparations for the treatment of inflammatory muscle diseases and disorders; pharmaceutical preparations for the treatment of muscle spasms, tremors and pain; pharmaceutical preparations for the treatment of musculoskeletal diseases, disorders and injuries namely connective tissue diseases, bone diseases and osteoporosis; pharmaceutical preparations for the treatment of smoking cessation; pharmaceutical preparations for the treatment of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases; pharmaceutical preparations for treating allergic rhinitis and asthma; pharmaceutical preparations for treating malignant tumors; pharmaceutical preparations for use in chemotherapy; pharmaceutical preparations namely, anti-inflammatories; psychiatric pharmaceutical preparations for the prevention and treatment of mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; steroids; tumor suppressing agents

Produits et services

(1) Analgesics; antacids; anti-cancer preparations; antibiotics; anticoagulants; anticonvulsants; antidepressants; antidiabetic preparations; antifungal preparations; antihypertensives; antiseptic preparations; antivirals; calcium channel blockers; corticosteroids; laxatives; nausea treatment preparations; pharmaceutical preparations for controlling cholesterol; pharmaceutical preparations for maintaining normal blood pressure and heart function; pharmaceutical preparations for reducing cholesterol; pharmaceutical preparations for the prevention and treatment of cancer; pharmaceutical preparations for the prevention and treatment of iron deficiency and anemia in humans; pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; pharmaceutical preparations for the treatment and prevention of migraines, headaches and pain; pharmaceutical preparations for the treatment of blood disorders; pharmaceutical preparations for the treatment of dermatological conditions being acne, rosacea, ichthyosis, vitiligo, urticaria and alopecia areata; pharmaceutical preparations for the treatment of dermatological diseases and disorders namely dermatitis, skin and bacterial skin infections and fungal skin infections.; pharmaceutical preparations for the treatment of digestive diseases and disorders, namely, ulcerative colitis; pharmaceutical preparations for the treatment of erectile dysfunction; pharmaceutical preparations for the treatment of gastro-intestinal diseases; pharmaceutical preparations for the treatment of inflammatory muscle diseases and disorders; pharmaceutical preparations for the treatment of muscle spasms, tremors and pain; pharmaceutical preparations for the treatment of musculoskeletal diseases, disorders and injuries namely connective tissue diseases, bone diseases and osteoporosis; pharmaceutical preparations for the treatment of smoking cessation; pharmaceutical preparations for the treatment of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases; pharmaceutical preparations for treating allergic rhinitis and asthma; pharmaceutical preparations for treating malignant tumors; pharmaceutical preparations for use in chemotherapy; pharmaceutical preparations namely, anti-inflammatories; psychiatric pharmaceutical preparations for the prevention and treatment of mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; steroids; tumor suppressing agents

Classes IPC  ?

• A61K 31/015 - Hydrocarbures carbocycliques
• A61K 31/035 - Hydrocarbures halogénés ayant une insaturation aliphatique
• A61K 31/13 - Amines, p. ex. amantadine
• A61K 31/131 - Amines, p. ex. amantadine acycliques

Abrégé

The present disclosure provides a topical sprayable composition comprising: (a) about 0.05% to about 5% by weight naftifine or pharmaceutical acceptable salt thereof, (b) a film forming agent comprising octylacrylamide acrylate copolymer and, (c) an alcoholic solvent, topical spray composition wherein the ratio of the alcoholic solvent to the propellant in the composition is about 1:1 to about 3:1 (w/w). The disclosure also provides a method of treating a dermatophyte skin infection or onychomycosis in a subject in need thereof, the method comprising topically administering to the subject the topical compositions as described herein.

Classes IPC  ?

• A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
• A61K 9/12 - AérosolsMousses
• A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
• A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• A61P 31/10 - Antifongiques
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 9/70 - Bases pour bande, feuille ou filament
• A61M 35/00 - Dispositifs pour appliquer des agents, p. ex. des remèdes, sur le corps humain

Abrégé

The present disclosure provides a topical sprayable composition comprising: (a) about 0.05% to about 5% by weight naftifine or pharmaceutical acceptable salt thereof, (b) a film forming agent comprising octylacrylamide acrylate copolymer and, (c) an alcoholic solvent, topical spray composition wherein the ratio of the alcoholic solvent to the propellant in the composition is about 1:1 to about 3:1 (w/w). The disclosure also provides a method of treating a dermatophyte skin infection or onychomycosis in a subject in need thereof, the method comprising topically administering to the subject the topical composition s as described herein.

Classes IPC  ?

• A61K 31/015 - Hydrocarbures carbocycliques
• A61K 31/035 - Hydrocarbures halogénés ayant une insaturation aliphatique
• A61K 31/13 - Amines, p. ex. amantadine
• A61K 31/131 - Amines, p. ex. amantadine acycliques

Abrégé

Compounds of formula (I): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

Classes IPC  ?

• C07D 493/10 - Systèmes condensés en spiro
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• C07D 231/54 - Composés hétérocycliques contenant des cycles diazole-1, 2 ou diazole-1, 2 hydrogéné condensés avec des carbocycles ou avec des systèmes carbocycliques
• C07D 401/08 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
• C07D 403/08 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
• C07D 417/08 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques

Produits et services

(1) Analgesics; antacids; anti-cancer preparations; antibiotics; anticoagulants; anticonvulsants; antidepressants; antidiabetic preparations; antifungal preparations; antihypertensives; antiseptic preparations; antivirals; calcium channel blockers; corticosteroids; laxatives; nausea treatment preparations; pharmaceutical preparations for controlling cholesterol; pharmaceutical preparations for maintaining normal blood pressure and heart function; pharmaceutical preparations for reducing cholesterol; pharmaceutical preparations for the prevention and treatment of cancer; pharmaceutical preparations for the prevention and treatment of iron deficiency and anemia in humans; pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; pharmaceutical preparations for the treatment and prevention of migraines, headaches and pain; pharmaceutical preparations for the treatment of blood disorders; pharmaceutical preparations for the treatment of dermatological conditions being acne, rosacea, ichthyosis, vitiligo, urticaria and alopecia areata; pharmaceutical preparations for the treatment of dermatological diseases and disorders namely dermatitis, skin and bacterial skin infections and fungal skin infections.; pharmaceutical preparations for the treatment of digestive diseases and disorders, namely, ulcerative colitis; pharmaceutical preparations for the treatment of erectile dysfunction; pharmaceutical preparations for the treatment of gastro-intestinal diseases; pharmaceutical preparations for the treatment of inflammatory muscle diseases and disorders; pharmaceutical preparations for the treatment of muscle spasms, tremors and pain; pharmaceutical preparations for the treatment of musculoskeletal diseases, disorders and injuries namely connective tissue diseases, bone diseases and osteoporosis; pharmaceutical preparations for the treatment of smoking cessation; pharmaceutical preparations for the treatment of the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases; pharmaceutical preparations for treating allergic rhinitis and asthma; pharmaceutical preparations for treating malignant tumors; pharmaceutical preparations for use in chemotherapy; pharmaceutical preparations namely, anti-inflammatories; psychiatric pharmaceutical preparations for the prevention and treatment of mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; steroids; tumor suppressing agents

Abrégé

The present disclosure provides methods of treating an inflammatory ocular condition, the methods comprising topically administering to an ocular surface of a subject in need thereof a composition comprising an allylamine, for example, terbinafine, naftifine, or a pharmaceutically acceptable salt, conjugate or derivative thereof. The present disclosure also provides methods of treating an ocular condition selected from keratitis, chronic conjunctivitis, allergic conjunctivitis, dry-eye disease, blepharitis, uveitis or combinations thereof, the methods comprising topically administering to an ocular surface of a subject in need thereof a composition comprising an allylamine, for example, terbinafine or pharmaceutically acceptable salt, conjugate or derivative thereof.

Classes IPC  ?

• A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
• A61K 31/13 - Amines, p. ex. amantadine
• A61K 31/135 - Amines, p. ex. amantadine ayant des cycles aromatiques, p. ex. méthadone
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

Embodiments of stable topical compositions for administering fenoldopam (compound (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed for immediate or continued slow release administration, over prolonged periods of time with safe minimal systemic exposure of fenoldopam (reducing the risk for lowering blood pressure). The compositions include those compositions that increase the stability and skin absorption of the drug, particularly anhydrous semi-solid compositions and creams. This is accomplished by incorporating fenoldopam in soluble or dispersed form into semi-solid compositions like ointments or anhydrous gels that are not irritative. Embodiments of methods for using the topical compositions in the treatment of dermatological disorders including psoriasis, alopecia atopic dermatitis and vitiligo are disclosed. Embodiments of stable topical compositions for administering fenoldopam (compound (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed for immediate or continued slow release administration, over prolonged periods of time with safe minimal systemic exposure of fenoldopam (reducing the risk for lowering blood pressure). The compositions include those compositions that increase the stability and skin absorption of the drug, particularly anhydrous semi-solid compositions and creams. This is accomplished by incorporating fenoldopam in soluble or dispersed form into semi-solid compositions like ointments or anhydrous gels that are not irritative. Embodiments of methods for using the topical compositions in the treatment of dermatological disorders including psoriasis, alopecia atopic dermatitis and vitiligo are disclosed.

Classes IPC  ?

• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
• A61P 17/06 - Antipsoriasiques
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/06 - OnguentsExcipients pour ceux-ci
• A61K 9/12 - AérosolsMousses
• A61K 9/70 - Bases pour bande, feuille ou filament
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
• A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères

Abrégé

An oral care device includes a housing having a first end and a second end. The first end of the housing includes an opening that receives an external suction tube. The second end of the housing includes a cleaning portion. The oral care device includes a hollow tube disposed within the housing and configured to couple with the external suction tube. The hollow tube includes a suction aperture at an end proximate to the cleaning portion of the housing. The hollow tube is configured to slide within the housing to expose or conceal the suction aperture. The oral care device includes a fluid dispenser coupled to the housing and fluidly coupled to at least one channel defined in part by the housing.

Classes IPC  ?

• A46B 11/06 - Brosses à réservoir ou autre système permettant l'application de produits, p. ex. peintures, pâtes, eau reliées à un tuyau d'alimentation
• A46B 9/00 - Agencement des soies dans la monture
• A61C 17/12 - Dispositifs de commande, p. ex. pour l'aspiration
• A61C 17/22 - Dispositifs à entraînement mécanique pour nettoyer ou pour polir avec des brosses, des éponges, des cupules ou analogues
• A46B 9/04 - Position ou disposition des soies par rapport à la surface de la monture, p. ex. inclinées, en rangées, en groupes pour les brosses à dents
• A46B 11/00 - Brosses à réservoir ou autre système permettant l'application de produits, p. ex. peintures, pâtes, eau
• A46B 11/04 - Brosses à réservoir ou autre système permettant l'application de produits, p. ex. peintures, pâtes, eau avec écoulement du produit du réservoir autrement que par pression

Abrégé

The present disclosure provides a process for the preparation of Trifarotene. The disclosure also provides novel intermediates in the process described herein. Also provided are novel polymorphs of Trifarotene. The present disclosure provides a process for the preparation of Trifarotene. The disclosure also provides novel intermediates in the process described herein. Also provided are novel polymorphs of Trifarotene.

Classes IPC  ?

• C07D 207/08 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec uniquement des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux hydrocarbonés, substitués par des hétéro-atomes, liés aux atomes de carbone du cycle

Produits et services

downloadable computer software and computer application software for computers, mobile phones, computer tablets, portable media players, smartwatches and handheld computers for use in monitoring skin conditions; downloadable computer software for providing users with information in the field of dermatology

Abrégé

A topical formulation comprising Montelukast or a pharmaceutically acceptable salt thereof, a gelling agent and water for the treatment of atopic dermatitis.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur

Produits et services

(1) Medicated diaper rash spray

Produits et services

Non-medicated cleansers, namely, skin cleansers, facial cleansers; face and body moisturizers; non-medicated balms for use on skin; non-medicated skin care preparations, namely, gels; non-medicated skin serums. Medicated balms for treatment of skin; medicated skin care preparations, namely, gels; medicated serums for treatment of skin.

Produits et services

(1) Non-medicated cleansers, namely, skin cleansers, facial cleansers; face and body moisturizers; non-medicated balms for use on skin; non-medicated skin care preparations, namely, gels; non-medicated skin serums. (2) Medicated balms for treatment of acne; medicated skin care preparations, namely, gels for the treatment of acne; medicated serums for treatment of acne.

Abrégé

The present invention relates to a novel and unexpected method of using topical Capecitabine composition to obtain therapeutically effective amounts of fluorouracil (FU) within the skin of a subject afflicted with hyperproliferative or inflammatory skin condition. The method comprising topically administering a pharmaceutical composition comprising Capecitabine or a hydrate or solvate thereof to the affected area of the skin of the subject, to form therapeutically effective amounts of FU within the skin.

Classes IPC  ?

• A61K 31/7068 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p. ex. cytidine, acide cytidylique
• A61P 17/12 - Kératolytiques, p. ex. préparations pour le traitement des verrues ou des cors
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
• A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
• A61K 31/4412 - Pyridines non condenséesLeurs dérivés hydrogénés ayant des groupes oxo liés directement à l'hétérocycle
• A61K 31/513 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime ayant des groupes oxo liés directement à l'hétérocycle, p. ex. cytosine

Produits et services

Non-medicated cleansers, namely, skin cleansers, facial cleansers; face and body moisturizers; non-medicated balms for use on skin; non-medicated skin care preparations, namely, gels; non-medicated skin serums Medicated balms for treatment of skin; medicated skin care preparations, namely, gels; medicated serums for treatment of skin

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations. Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations.

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, age retardant lotions and gels, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; shampoo; hair conditioner; hair gel, beauty gel, shower gel, shaving gel; heat protectant sprays for hair; hair styling spray; make-up; make-up remover; douching preparations for personal sanitary or deodorant purposes. Medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations; medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations; dietary, vitamin and mineral supplements; sanitary pads, sanitary napkins, sanitary tampons; gels for use as personal lubricant. Retail store services connected with the sale of skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, hair conditioner, hair gel, beauty gel, shower gel, shaving gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons; online retail store services connected with the sale of skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, hair conditioner, hair gel, beauty gel, shower gel, shaving gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons.

Abrégé

The present disclosure provides formulations comprising desoximetasone, tazarotene, a polymer comprising polyurethane, and a solvent. Also provided herein are methods of co-administering desoximetasone and tazarotene.

Classes IPC  ?

• A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
• A61K 31/4436 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un hétérocycle avec le soufre comme hétéro-atome du cycle
• A61K 47/59 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes
• A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline

Abrégé

The present disclosure provides a process for the preparation of Trifarotene. The disclosure also provides novel intermediates in the process described herein. Also provided are novel polymorphs of Trifarotene.

Classes IPC  ?

• C07D 207/08 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec uniquement des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux hydrocarbonés, substitués par des hétéro-atomes, liés aux atomes de carbone du cycle

Produits et services

(1) Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations. (2) Acne treatment preparations; medicated skin care preparations for use as skin cleansers; medicated facial exfoliating pads containing a glycolic acid; medicated skin serums for the treatment of acne, glabellar lines, facial wrinkles, and severe dry and itchy skin; medicated skin care preparations for use as moisturizers; medicated sun screens; medicated skin care preparations for the treatment of acne, glabellar lines, facial wrinkles, and severe dry and itchy skin.

Produits et services

(1) Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, age retardant lotions and gels, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; shampoo; hair conditioner; hair gel, beauty gel, shower gel, shaving gel; heat protectant sprays for hair; hair styling spray; make-up; make-up remover; douching preparations for personal sanitary or deodorant purposes. (2) Medicated skin cleansers; medicated facial exfoliating pads containing a glycolic acid; medicated skin serums for the treatment of acne, glabellar lines, facial wrinkles, and severe dry and itchy skin; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations; medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations; dietary, vitamin and mineral supplements; sanitary pads, sanitary napkins, sanitary tampons; gels for use as personal lubricant. (1) Retail store services featuring skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, hair conditioner, hair gel, beauty gel, shower gel, shaving gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons; online retail store services featuring skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, hair conditioner, hair gel, beauty gel, shower gel, shaving gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons.

Produits et services

Non-medicated skin care preparations, namely, skin concealers, skin conditioners, skin cream, skin lotions, skin moisturizers, skin facial mousse being skin cleansers and cosmetic masks, skin abrasive preparations, skin clarifiers, skin cleansers, skin cleaning cream, skin cleansing lotion, skin emollients, skin soaps Acne treatment preparations

Produits et services

Medicated diaper rash spray

Abrégé

The present disclosure provides an oral care device including a hollow shaft (120, 920, 1320), a sleeve (110, 910, 1310), and a cleaning portion (115). The hollow shaft can include a first end having a first suction aperture (140, 940, 1340), and a second end having a second suction aperture (125, 925). The hollow shaft can be configured for insertion into a hand grip. The sleeve can surround the hollow shaft of the oral care device, and can be configured to slide along a longitudinal axis and conceal at least a portion of the first suction aperture or the second suction aperture. The sleeve can conceal the first suction aperture or the second suction aperture to easily adjust an amount of suction provided to an oral cavity of a patient. The cleaning portion can be coupled to a portion of the sleeve at the first end of the hollow shaft.

Classes IPC  ?

• A46B 11/06 - Brosses à réservoir ou autre système permettant l'application de produits, p. ex. peintures, pâtes, eau reliées à un tuyau d'alimentation
• A61C 17/12 - Dispositifs de commande, p. ex. pour l'aspiration
• A61C 17/22 - Dispositifs à entraînement mécanique pour nettoyer ou pour polir avec des brosses, des éponges, des cupules ou analogues

Abrégé

The present disclosure provides an oral care device including a hollow shaft (120, 920, 1320), a sleeve (110, 910, 1310), and a cleaning portion (115). The hollow shaft can include a first end having a first suction aperture (140, 940, 1340), and a second end having a second suction aperture (125, 925). The hollow shaft can be configured for insertion into a hand grip. The sleeve can surround the hollow shaft of the oral care device, and can be configured to slide along a longitudinal axis and conceal at least a portion of the first suction aperture or the second suction aperture. The sleeve can conceal the first suction aperture or the second suction aperture to easily adjust an amount of suction provided to an oral cavity of a patient. The cleaning portion can be coupled to a portion of the sleeve at the first end of the hollow shaft.

Classes IPC  ?

• A46B 11/06 - Brosses à réservoir ou autre système permettant l'application de produits, p. ex. peintures, pâtes, eau reliées à un tuyau d'alimentation
• A46B 9/00 - Agencement des soies dans la monture
• A61C 17/12 - Dispositifs de commande, p. ex. pour l'aspiration
• A61C 17/22 - Dispositifs à entraînement mécanique pour nettoyer ou pour polir avec des brosses, des éponges, des cupules ou analogues

Abrégé

5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

Classes IPC  ?

• C07D 493/10 - Systèmes condensés en spiro
• C07D 231/54 - Composés hétérocycliques contenant des cycles diazole-1, 2 ou diazole-1, 2 hydrogéné condensés avec des carbocycles ou avec des systèmes carbocycliques
• C07D 401/08 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
• C07D 403/08 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
• C07D 417/08 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]

Produits et services

(1) Medicated diaper rash spray

Produits et services

(1) Computer application software for mobile phones, portable media players, handheld tablets, and computers, namely, software for internet and/or mobile access to medical content, medical calculators, healthcare news and other pharmacy management resources directed to enhance patient care and advance pharmacy practice; Computer software namely, software applications allowing healthcare professionals, pharmacists, their assistants and sales employees to update and receive data stored in a centralized databases in real time, using a mobile device or computers, with full telephone integration using the telephone and/or software features of the mobile device or computer; Electronic newsletters in the field of patient care, medication, health, pharmaceutical, medical and clinical related questions and issues; update and receive data stored in a centralized databases in real time, using a mobile device or computers (1) Provision of reports, industry analysis, news and industry trends in the field of patient care, medication, medicine, healthcare and pharmacy (2) Digital platform that provides information relating to patient care, medication, medical, health, pharmaceutical and clinical related questions and issues (3) Provision of educational services in the field of patient care, medication, health, pharmaceutical, medical and clinical related questions and issues (4) Advisory services in the field of patient care, medication, health, pharmaceutical, medical and clinical related questions and issues

Produits et services

(1) Computer application software for mobile phones, portable media players, handheld tablets, and computers, namely, software for internet and/or mobile access to medical content, medical calculators, healthcare news and other pharmacy management resources directed to enhance patient care and advance pharmacy practice; Computer software namely, software applications allowing healthcare professionals, pharmacists, their assistants and sales employees to update and receive data stored in a centralized databases in real time, using a mobile device or computers, with full telephone integration using the telephone and/or software features of the mobile device or computer; Electronic newsletters in the field of patient care, medication, health, pharmaceutical, medical and clinical related questions and issues; update and receive data stored in a centralized databases in real time, using a mobile device or computers (1) Provision of reports, industry analysis, news and industry trends in the field of patient care, medication, medicine, healthcare and pharmacy (2) Digital platform that provides information relating to patient care, medication, medical, health, pharmaceutical and clinical related questions and issues (3) Provision of educational services in the field of patient care, medication, health, pharmaceutical, medical and clinical related questions and issues (4) Advisory services in the field of patient care, medication, health, pharmaceutical, medical and clinical related questions and issues

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; hair shampoo and hair conditioners. Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations.

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, age retardant lotions and gels, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; shampoo; hair conditioner; hair gel, beauty gel, shower gel, shaving gel; heat protectant sprays for hair; hair styling spray; make-up; make-up remover; douching preparations for personal sanitary or deodorant purposes Medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations; medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations; dietary, vitamin and mineral supplements; sanitary pads, sanitary napkins, sanitary tampons; gels for use as personal lubricant Retail store services featuring skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, hair conditioner, hair gel, beauty gel, shower gel, shaving gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons; Online retail store services featuring skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, hair conditioner, hair gel, beauty gel, shower gel, shaving gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons

Produits et services

(1) Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; hair shampoo and hair conditioners. (2) Acne treatment preparations; medicated skin cleansers for the treatment of acne; medicated facial exfoliating pads containing a glycolic ingredient for the treatment of acne; medicated skin serums for the treatment of acne; medicated skin moisturizers for the treatment of acne; medicated sun screens with SPF; medicated skin care preparations for the treatment of acne.

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; hair shampoo and hair condition. Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations.

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; hair shampoo and hair conditioners Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; hair shampoo and hair conditioners. Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations.

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; hair shampoo and hair condition. Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations.

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; hair shampoo and hair condition. Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations.

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations. Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations.

Produits et services

(1) Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; hair shampoo and hair conditioners. (2) Acne treatment preparations; medicated skin cleansers for the treatment of acne; medicated facial exfoliating pads containing a glycolic ingredient for the treatment of acne; medicated skin serums for the treatment of acne; medicated skin moisturizers for the treatment of acne; medicated sun screens with SPF; medicated skin care preparations for the treatment of acne.

Produits et services

(1) Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; hair shampoo and hair conditioners. (2) Acne treatment preparations; medicated skin cleansers for the treatment of acne; medicated facial exfoliating pads containing a glycolic ingredient for the treatment of acne; medicated skin serums for the treatment of acne; medicated skin moisturizers for the treatment of acne; medicated sun screens with SPF; medicated skin care preparations for the treatment of acne.

Produits et services

(1) Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; hair shampoo and hair conditioners. (2) Acne treatment preparations; medicated skin cleansers for the treatment of acne; medicated facial exfoliating pads containing a glycolic ingredient for the treatment of acne; medicated skin serums for the treatment of acne; medicated skin moisturizers for the treatment of acne; medicated sun screens with SPF; medicated skin care preparations for the treatment of acne.

Produits et services

(1) Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; non-medicated skin care preparations. (2) Acne treatment preparations; medicated skin cleansers for the treatment of acne; medicated facial exfoliating pads containing a glycolic ingredient for the treatment of acne; medicated skin serums for the treatment of acne; medicated skin moisturizers for the treatment of acne; medicated sun screens with SPF; medicated skin care preparations for the treatment of acne.

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; hair shampoo and hair conditioners Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; hair shampoo and hair conditioners Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; non-medicated skin care preparations Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations

Produits et services

(1) Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations. (2) Acne treatment preparations; medicated skin cleansers for the treatment of acne; medicated facial exfoliating pads containing a glycolic ingredient for the treatment of acne; medicated skin serums for the treatment of acne; medicated skin moisturizers for the treatment of acne; medicated sun screens with SPF; medicated skin care preparations for the treatment of acne.

Produits et services

(1) Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; non-medicated skin care preparations. (2) Acne treatment preparations; medicated skin cleansers for the treatment of acne; medicated facial exfoliating pads containing a glycolic ingredient for the treatment of acne; medicated skin serums for the treatment of acne; medicated skin moisturizers for the treatment of acne; medicated sun screens with SPF; medicated skin care preparations for the treatment of acne.

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations. Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations.

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; non-medicated skin care preparations Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations

Abrégé

The present disclosure is directed to a topical composition, e.g., a physically and chemically stable topical composition of Fenoldopam comprising about 0.1% to about 5% by weight of Fenoldopam or a pharmaceutically acceptable salt thereof, at least one polyacrylamide-type gelling agent, at least one cellulose-type gelling agent, and at least one solvent, wherein the Fenoldopam is substantially solubilized in the composition, and wherein the composition is stable for at least twelve months at 25° C. and 60% relative humidity.

Classes IPC  ?

• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
• A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
• A61K 47/38 - CelluloseSes dérivés
• A61P 17/06 - Antipsoriasiques
• A61P 17/04 - Antiprurigineux
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

The present disclosure provides for topical emulsion comprising about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; and about 0.4% to about 4% carbomer; wherein particles comprising the Montelukast in the emulsion have D90 of less than about 50 wherein the Montelukast or pharmaceutically acceptable salt thereof is homogeneously dispersed in the emulsion, and wherein the emulsion has a pH of about 3.0 to about 6.5. The present disclosure also provides a topical gel comprising (a) about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; (b) about 0.2% to about 8% cellulose polymer; and (c) about 80% to about 95% amphiphilic compound; wherein the gel comprises less than 4% water.

Classes IPC  ?

• A61K 9/107 - Émulsions
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères

Abrégé

The present disclosure provides for topical emulsion comprising about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; and about 0.4% to about 4% carbomer; wherein particles comprising the Montelukast in the emulsion have D90 of less than about 50 μm, wherein the Montelukast or pharmaceutically acceptable salt thereof is homogeneously dispersed in the emulsion, and wherein the emulsion has a pH of about 3.0 to about 6.5. The present disclosure also provides a topical gel comprising (a) about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; (b) about 0.2% to about 8% cellulose polymer; and (c) about 80% to about 95% amphiphilic compound; wherein the gel comprises less than 4% water.

Classes IPC  ?

• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/107 - Émulsions
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61P 17/04 - Antiprurigineux

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, age retardant lotions and gels, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; shampoo; skin conditioners; bath gels; heat protectant sprays for hair; hair styling spray; make-up; make-up remover; douching preparations for personal sanitary or deodorant purposes. Medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations; medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations; dietary, vitamin and mineral supplements; sanitary pads, sanitary napkins, sanitary tampons. Retail store services connected with the sale of skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, conditioner, gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons; online retail store services connected with the sale of skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, conditioner, gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons.

Produits et services

Medicated diaper rash spray

Produits et services

(1) Pharmaceutical preparations and substances for the treatment of coughs, colds and influenza; pharmaceutical preparations for reducing fever; decongestants; cough suppressants; pharmaceutical antitussive-cold preparations; Pharmaceutical preparations for the treatment and prevention of gastrointestinal diseases and disorders; Pharmaceutical preparations for treatment of alopecia; preparations for the treatment of respiratory and pulmonary conditions; expectorants; anti-pyretic preparations; allergy relief medication; allergy and sinus medication; antihistamines; nasal decongestants; analgesics and pain relievers; menstrual pain relief medications; Emergency contraceptive tablets; emergency contraceptive kit composed of oral contraceptives, pregnancy test kits for home use and instructions sold in connection therewith; anti-fungal preparations; Acetaminophen; acetaminophen suppositories

Produits et services

(1) Pharmaceutical preparations and substances for the treatment of coughs, colds and influenza; pharmaceutical preparations for reducing fever; decongestants; cough suppressants; pharmaceutical antitussive-cold preparations; Pharmaceutical preparations for the treatment and prevention of gastrointestinal diseases and disorders; Pharmaceutical preparations for treatment of alopecia; preparations for the treatment of respiratory and pulmonary conditions; expectorants; anti-pyretic preparations; allergy relief medication; allergy and sinus medication; antihistamines; nasal decongestants; analgesics and pain relievers; menstrual pain relief medications; Emergency contraceptive tablets; emergency contraceptive kit composed of oral contraceptives, pregnancy test kits for home use and instructions sold in connection therewith; anti-fungal preparations; Acetaminophen; acetaminophen suppositories

Produits et services

Encapsulated benzoyl peroxide sold as an integral ingredient of skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, cosmetics, non-medicated skin care preparations. Encapsulated benzoyl peroxide sold as an integral ingredient of acne treatment preparations.

Produits et services

Medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; dietary supplements and probiotic supplements.

Abrégé

The present disclosure provides formulations comprising desoximetasone, tazarotene, a polymer comprising polyurethane, and a solvent. Also provided herein are methods of co-administering desoximetasone and tazarotene.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/4436 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un hétérocycle avec le soufre comme hétéro-atome du cycle
• A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques

Abrégé

The present disclosure provides for topical emulsion comprising about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; and about 0.4% to about 4% carbomer; wherein particles comprising the Montelukast in the emulsion have D90 of less than about 50 ?m, wherein the Montelukast or pharmaceutically acceptable salt thereof is homogeneously dispersed in the emulsion, and wherein the emulsion has a pH of about 3.0 to about 6.5. The present disclosure also provides a topical gel comprising (a) about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; (b) about 0.2% to about 8% cellulose polymer; and (c) about 80% to about 95% amphiphilic compound; wherein the gel comprises less than 4% water.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/06 - OnguentsExcipients pour ceux-ci
• A61K 9/107 - Émulsions
• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• A61P 17/04 - Antiprurigineux
• A61P 17/06 - Antipsoriasiques
• A61P 17/08 - Antiséborrhéiques
• A61P 17/10 - Antiacnéïques

Abrégé

The present disclosure provides for topical emulsion comprising about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; and about 0.4% to about 4% carbomer; wherein particles comprising the Montelukast in the emulsion have D90 of less than about 50 μm, wherein the Montelukast or pharmaceutically acceptable salt thereof is homogeneously dispersed in the emulsion, and wherein the emulsion has a pH of about 3.0 to about 6.5. The present disclosure also provides a topical gel comprising (a) about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; (b) about 0.2% to about 8% cellulose polymer; and (c) about 80% to about 95% amphiphilic compound; wherein the gel comprises less than 4% water.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/06 - OnguentsExcipients pour ceux-ci
• A61K 9/107 - Émulsions
• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• A61P 17/04 - Antiprurigineux
• A61P 17/06 - Antipsoriasiques
• A61P 17/08 - Antiséborrhéiques
• A61P 17/10 - Antiacnéïques

Abrégé

The present disclosure provides for topical emulsion comprising about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; and about 0.4% to about 4% carbomer; wherein particles comprising the Montelukast in the emulsion have D90 of less than about 50 μm, wherein the Montelukast or pharmaceutically acceptable salt thereof is homogeneously dispersed in the emulsion, and wherein the emulsion has a pH of about 3.0 to about 6.5. The present disclosure also provides a topical gel comprising (a) about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; (b) about 0.2% to about 8% cellulose polymer; and (c) about 80% to about 95% amphiphilic compound; wherein the gel comprises less than 4% water.

Classes IPC  ?

• A61K 9/107 - Émulsions
• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Produits et services

(1) Pharmaceutical preparations for the treatment of alopecia

Produits et services

(1) Encapsulated benzoyl peroxide sold as an integral ingredient of skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, cosmetics, non-medicated skin care preparations. (2) Encapsulated benzoyl peroxide sold as an integral ingredient of acne treatment preparations.

Produits et services

(1) Dietary supplements for general health and wellbeing; probiotic supplements

Produits et services

Pharmaceutical preparations for use in dermatology

Produits et services

(1) Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, age retardant lotions and gels, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; shampoo; hair conditioner; hair gel, beauty gel, shower gel, shaving gel; heat protectant sprays for hair; hair styling spray; make-up; make-up remover; douching preparations for personal sanitary or deodorant purposes. (2) Medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations; medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations; dietary, vitamin and mineral supplements; sanitary pads, sanitary napkins, sanitary tampons; gels for use as personal lubricant. (1) Retail store services featuring skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, hair conditioner, hair gel, beauty gel, shower gel, shaving gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons; online retail store services featuring skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, hair conditioner, hair gel, beauty gel, shower gel, shaving gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons.

Abrégé

The present disclosure provides a process for the preparation of Trifarotene. The disclosure also provides novel intermediates in the process described herein. Also provided are novel polymorphs of Trifarotene.

Classes IPC  ?

• C07D 207/06 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec uniquement des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux contenant uniquement des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle
• A61K 31/402 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil substitués par un groupe aryle en position 1, p. ex. pirétanide
• A61P 17/10 - Antiacnéïques

Abrégé

5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

Classes IPC  ?

• C07D 263/56 - BenzoxazolesBenzoxazoles hydrogénés avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement en position 2
• C07D 231/54 - Composés hétérocycliques contenant des cycles diazole-1, 2 ou diazole-1, 2 hydrogéné condensés avec des carbocycles ou avec des systèmes carbocycliques
• C07D 239/74 - QuinazolinesQuinazolines hydrogénées avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés aux atomes de carbone de l'hétéro-cycle
• C07D 241/42 - Benzopyrazines avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone de l'hétérocycle
• C07D 261/20 - Composés hétérocycliques contenant des cycles oxazole-1, 2 ou oxazole-1, 2 hydrogéné condensés avec des carbocycles ou avec des systèmes carbocycliques
• C07D 209/08 - IndolesIndoles hydrogénés avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone de l'hétérocycle
• C07D 277/64 - Benzothiazoles avec uniquement des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués liés en position 2
• C07D 285/14 - ThiadiazolesThiadiazoles hydrogénés condensés avec des carbocycles ou avec des systèmes carbocycliques
• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• C07D 413/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
• C07D 239/84 - Atomes d'azote
• C07D 401/08 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
• C07D 403/04 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07D 403/08 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
• C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons

Produits et services

Pharmaceutical preparations and substances for the treatment of coughs, colds and influenza; pharmaceutical preparations for reducing fever; decongestants; cough suppressants; pharmaceutical antitussive-cold preparations; Pharmaceutical preparations for the treatment and prevention of gastrointestinal diseases and disorders; Pharmaceutical preparations for treatment of alopecia; preparations for the treatment of respiratory and pulmonary conditions; expectorants; anti-pyretic preparations; allergy relief medication; allergy and sinus medication; antihistamines; nasal decongestants; analgesics and pain relievers; menstrual pain relief medications; Emergency contraceptive tablets; emergency contraceptive kit composed of oral contraceptives, pregnancy test kits for home use and instructions sold in connection therewith; anti-fungal preparations; Acetaminophen; acetaminophen suppositories

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, age retardant lotions and gels, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; shampoo; hair conditioner; hair gel; beauty gel; shower gel; shaving gel; heat protectant sprays for hair; hair styling spray; make-up; make-up remover; douching preparations for personal sanitary or deodorant purposes Medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations; medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations; dietary, vitamin and mineral supplements; sanitary pads, sanitary napkins, sanitary tampons Retail store services connected with the sale of skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, hair conditioner, hair gel, beauty gel, shower gel, shaving gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons; Online retail store services connected with the sale of skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, hair conditioner, hair gel, beauty gel, shower gel, shaving gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons

Produits et services

Non-medicated cleansers, namely, skin cleansers, facial cleansers; exfoliating pads containing a glycolic ingredient not for medical purposes; skin moisturizer; facial moisturizer with SPF; skin moisturizing gel; non-medicated skin serums. Medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers.

Produits et services

dietary, vitamin and mineral supplements

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations Acne treatment preparations; medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations

Abrégé

The present invention relates to a novel and unexpected method of using topical Capecitabine composition to obtain therapeutically effective amounts of fluorouracil (FU) within the skin of a subject afflicted with hyperproliferative or inflammatory skin condition. The method comprising topically administering a pharmaceutical composition comprising Capecitabine or a hydrate or solvate thereof to the affected area of the skin of the subject, to form therapeutically effective amounts of FU within the skin.

Classes IPC  ?

• A61K 31/7068 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p. ex. cytidine, acide cytidylique
• A61P 17/12 - Kératolytiques, p. ex. préparations pour le traitement des verrues ou des cors
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
• A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
• A61K 31/4412 - Pyridines non condenséesLeurs dérivés hydrogénés ayant des groupes oxo liés directement à l'hétérocycle
• A61K 31/513 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime ayant des groupes oxo liés directement à l'hétérocycle, p. ex. cytosine

Produits et services

Skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, age retardant lotions and gels, skin soaps, sun screen preparations; cosmetics; non-medicated skin care preparations; shampoo; hair conditioner; hair gel, beauty gel, shower gel, shaving gel; heat protectant sprays for hair; hair styling spray; make-up; make-up remover; douching preparations for personal sanitary or deodorant purposes Medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers; medicated sun screens with SPF; medicated skin care preparations; medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations; dietary, vitamin and mineral supplements; sanitary pads, sanitary napkins, sanitary tampons; gels for use as personal lubricant Retail store services featuring skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, hair conditioner, hair gel, beauty gel, shower gel, shaving gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons; Online retail store services featuring skin cleansers, skin moisturizers, skin lotions, skin soaps, sun screen preparations, cosmetics, non-medicated skin care preparations, shampoo, hair conditioner, hair gel, beauty gel, shower gel, shaving gel, heat protectant sprays for hair, hair styling spray, make-up, make-up remover, douching preparations for personal sanitary or deodorant purposes, medicated skin cleansers, medicated facial exfoliating pads containing a glycolic ingredient for medical purposes, medicated skin serums, medicated skin moisturizers, medicated sun screens with SPF, medicated skin care preparations, medicated skin care preparations for the treatment of glabellar lines and facial wrinkles, medicated hair care preparations, dietary, vitamin and mineral supplements, sanitary pads, sanitary napkins, sanitary tampons

Produits et services

Non-medicated cleansers, namely, skin cleansers, facial cleansers; face and body moisturizers; non-medicated balms for use on skin; non-medicated skin care preparations, namely, gels; non-medicated skin serums. Medicated balms for treatment of skin; medicated skin care preparations, namely, gels; medicated serums for treatment of skin; probiotic and dietary supplements.

Abrégé

5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

Classes IPC  ?

• C07D 493/10 - Systèmes condensés en spiro
• C07D 231/54 - Composés hétérocycliques contenant des cycles diazole-1, 2 ou diazole-1, 2 hydrogéné condensés avec des carbocycles ou avec des systèmes carbocycliques
• C07D 401/08 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
• C07D 403/08 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
• C07D 417/08 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles alicycliques
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]

Produits et services

(1) Non-medicated cleansers, namely, skin cleansers, facial cleansers; exfoliating pads containing a glycolic ingredient not for medical purposes; skin moisturizer; facial moisturizer with SPF; skin moisturizing gel; non-medicated skin serums. (2) Medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums for the treatment of dry skin, eczema, psoriasis, rosacea, dermatitis, and acne; medicated skin moisturizers for the treatment of dry skin, eczema, psoriasis, rosacea, dermatitis, and acne.

Produits et services

(1) Non-medicated cleansers, namely, skin cleansers, facial cleansers; face and body moisturizers; nonmedicated balms for use on skin; non-medicated skin care preparations, namely, gels; non-medicated skin serums. (2) Medicated balms for treatment of skin, namely medications for the treatment of dry skin, eczema, psoriasis, rosacea, dermatitis, and acne; medicated skin care preparations, namely gels for the treatment of dry skin, eczema, psoriasis, rosacea, dermatitis, and acne; medicated serums for treatment of skin, namely medications for the treatment of dry skin, eczema, psoriasis, rosacea, dermatitis, and acne; probiotic dietary supplements and dietary supplements for humans for general health and well-being.

Produits et services

dietary supplements and probiotic supplements

Produits et services

Non-medicated cleansers, namely, skin cleansers, facial cleansers; exfoliating pads containing a glycolic ingredient not for medical purposes; skin moisturizer; facial moisturizer with SPF; skin moisturizing gel; non-medicated skin serums Medicated skin cleansers; medicated facial exfoliating pads containing a glycolic ingredient for medical purposes; medicated skin serums; medicated skin moisturizers

Produits et services

Handheld electronic medical devices for the non-surgical treatment of acne

Produits et services

Non-medicated cleansers, namely, skin cleansers, facial cleansers; face and body moisturizers; non-medicated balms for use on skin; non-medicated skin care preparations, namely, gels; non-medicated skin serums Medicated balms for treatment of skin; medicated skin care preparations, namely, gels; medicated serums for treatment of skin; probiotic and dietary supplements

Produits et services

encapsulated benzoyl peroxide sold as an integral ingredient of skin and body care preparations, namely, skin cleansers, skin moisturizers, skin lotions, skin soaps, cosmetics, non-medicated skin care preparations encapsulated benzoyl peroxide sold as an integral ingredient of acne treatment preparations